PSAT1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-serine metabolic process (GO:0006563)6.21244780
2ribosome assembly (GO:0042255)5.19312879
3establishment of integrated proviral latency (GO:0075713)5.12343095
4IMP biosynthetic process (GO:0006188)4.76394786
5IMP metabolic process (GO:0046040)4.57530956
6proteasome assembly (GO:0043248)4.54632768
7cullin deneddylation (GO:0010388)4.47146071
8protein localization to kinetochore (GO:0034501)4.42155371
9chromatin remodeling at centromere (GO:0031055)4.35122672
10water-soluble vitamin biosynthetic process (GO:0042364)4.33988464
11DNA double-strand break processing (GO:0000729)4.31197451
12CENP-A containing nucleosome assembly (GO:0034080)4.23776371
13somatic hypermutation of immunoglobulin genes (GO:0016446)4.21798028
14somatic diversification of immune receptors via somatic mutation (GO:0002566)4.21798028
15establishment of viral latency (GO:0019043)4.18816617
16DNA replication checkpoint (GO:0000076)4.18520992
17protein deneddylation (GO:0000338)4.16186353
18negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.11708450
19mitotic metaphase plate congression (GO:0007080)3.99978873
20regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.98928632
21serine family amino acid biosynthetic process (GO:0009070)3.97085494
22DNA strand elongation involved in DNA replication (GO:0006271)3.93946012
23tRNA aminoacylation for protein translation (GO:0006418)3.89698159
24DNA replication-dependent nucleosome organization (GO:0034723)3.88528025
25DNA replication-dependent nucleosome assembly (GO:0006335)3.88528025
26regulation of mitotic spindle checkpoint (GO:1903504)3.86359795
27regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.86359795
28amino acid activation (GO:0043038)3.84534762
29tRNA aminoacylation (GO:0043039)3.84534762
30histone exchange (GO:0043486)3.83898482
31purine nucleobase biosynthetic process (GO:0009113)3.83404705
32negative regulation of DNA recombination (GO:0045910)3.82518128
33folic acid-containing compound biosynthetic process (GO:0009396)3.80138937
34protein neddylation (GO:0045116)3.77314440
35DNA strand elongation (GO:0022616)3.74373321
36regulation of helicase activity (GO:0051095)3.73772479
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.72122783
38negative regulation of ligase activity (GO:0051352)3.72122783
39anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.70585957
40DNA replication-independent nucleosome organization (GO:0034724)3.64482267
41DNA replication-independent nucleosome assembly (GO:0006336)3.64482267
42lysine metabolic process (GO:0006553)3.61585031
43lysine catabolic process (GO:0006554)3.61585031
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.61380021
45non-recombinational repair (GO:0000726)3.61022015
46double-strand break repair via nonhomologous end joining (GO:0006303)3.61022015
47DNA damage response, detection of DNA damage (GO:0042769)3.59780693
48spindle checkpoint (GO:0031577)3.54506090
49nucleobase biosynthetic process (GO:0046112)3.47574730
50negative regulation of DNA-dependent DNA replication (GO:2000104)3.46195671
51metaphase plate congression (GO:0051310)3.46159633
52negative regulation of mitotic sister chromatid separation (GO:2000816)3.45244287
53negative regulation of sister chromatid segregation (GO:0033046)3.45244287
54negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.45244287
55negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.45244287
56negative regulation of mitotic sister chromatid segregation (GO:0033048)3.45244287
57attachment of spindle microtubules to kinetochore (GO:0008608)3.43617163
58negative regulation of chromosome segregation (GO:0051985)3.40953279
59mitotic spindle checkpoint (GO:0071174)3.40104899
60regulation of cellular amino acid metabolic process (GO:0006521)3.37263298
61DNA ligation (GO:0006266)3.36959048
62somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.35978108
63isotype switching (GO:0045190)3.35978108
64somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.35978108
65establishment of protein localization to mitochondrial membrane (GO:0090151)3.33329075
66regulation of centriole replication (GO:0046599)3.33154897
67telomere maintenance via semi-conservative replication (GO:0032201)3.31332578
68DNA catabolic process, exonucleolytic (GO:0000738)3.27630525
69protein localization to chromosome, centromeric region (GO:0071459)3.25320778
70spliceosomal snRNP assembly (GO:0000387)3.24737456
71formation of translation preinitiation complex (GO:0001731)3.15365539
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.13443448
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.13443448
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.13443448
75regulation of mitotic metaphase/anaphase transition (GO:0030071)3.13192560
76regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.13192560
77protein complex localization (GO:0031503)3.11556535
78DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.09114129
79mitotic spindle assembly checkpoint (GO:0007094)3.07112258
80signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.07079370
81intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.07079370
82histone H2A acetylation (GO:0043968)3.06938499
83spindle assembly checkpoint (GO:0071173)3.04593470
84RNA-dependent DNA replication (GO:0006278)3.04425871
85signal transduction involved in DNA integrity checkpoint (GO:0072401)3.04071170
86signal transduction involved in DNA damage checkpoint (GO:0072422)3.04071170
87telomere maintenance via telomerase (GO:0007004)3.03644138
88lactate metabolic process (GO:0006089)3.01413056
89signal transduction involved in cell cycle checkpoint (GO:0072395)3.00842309
90rRNA modification (GO:0000154)3.00640568
91positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.99916583
92telomere maintenance via telomere lengthening (GO:0010833)2.99574157
93regulation of sister chromatid segregation (GO:0033045)2.97682776
94regulation of mitotic sister chromatid separation (GO:0010965)2.97682776
95regulation of mitotic sister chromatid segregation (GO:0033047)2.97682776
96regulation of ubiquitin-protein transferase activity (GO:0051438)2.96901329
97somatic diversification of immunoglobulins (GO:0016445)2.96885708
98establishment of chromosome localization (GO:0051303)2.92683051
99mitotic nuclear envelope disassembly (GO:0007077)2.92682324
100transcription elongation from RNA polymerase III promoter (GO:0006385)2.92166164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.49910315
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.79301413
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.25937815
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.66170386
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.58574179
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.39631188
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.34497477
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.16631617
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.08135739
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.89230964
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.85824229
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.62026562
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53903463
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.53588753
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.52848475
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48891084
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.40639043
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.37330329
19ELK1_19687146_ChIP-ChIP_HELA_Human2.35617795
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30989954
21VDR_23849224_ChIP-Seq_CD4+_Human2.22584040
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19491948
23FOXP3_21729870_ChIP-Seq_TREG_Human2.19080109
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.16428910
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14797748
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.12777091
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12218015
28AR_21909140_ChIP-Seq_LNCAP_Human1.99154058
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95224015
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93822398
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92583310
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89468602
33DCP1A_22483619_ChIP-Seq_HELA_Human1.81117207
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80896845
35GABP_19822575_ChIP-Seq_HepG2_Human1.79426717
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.77521042
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.74118809
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72720488
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72305753
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71132902
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68810626
42ZNF274_21170338_ChIP-Seq_K562_Hela1.64677324
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.61544309
44XRN2_22483619_ChIP-Seq_HELA_Human1.59974884
45TTF2_22483619_ChIP-Seq_HELA_Human1.59918217
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59455327
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.59353108
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55377800
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55359434
50MYC_18940864_ChIP-ChIP_HL60_Human1.54023663
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50164337
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48080524
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46753694
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.45468068
55EWS_26573619_Chip-Seq_HEK293_Human1.44329248
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44056977
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43246020
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42552410
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42228889
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.40049328
61NANOG_16153702_ChIP-ChIP_HESCs_Human1.38311203
62VDR_22108803_ChIP-Seq_LS180_Human1.34597580
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33622718
64SOX2_16153702_ChIP-ChIP_HESCs_Human1.32782233
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31571631
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30752772
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28536399
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.27409941
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15622775
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12746466
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12276131
72TAF15_26573619_Chip-Seq_HEK293_Human1.11740308
73NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.10668303
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09168062
75FUS_26573619_Chip-Seq_HEK293_Human1.08471177
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03384651
77P300_19829295_ChIP-Seq_ESCs_Human1.03251655
78IRF1_19129219_ChIP-ChIP_H3396_Human1.01281429
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00673744
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00673744
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00673744
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00435987
83IGF1R_20145208_ChIP-Seq_DFB_Human0.98918180
84NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96908951
85PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96341150
86POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92237201
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91129353
88SOX17_20123909_ChIP-Seq_XEN_Mouse0.90897547
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89914078
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88255436
91ELK1_22589737_ChIP-Seq_MCF10A_Human0.87513103
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87448202
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86626755
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86352307
95KDM5A_27292631_Chip-Seq_BREAST_Human0.85039490
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83967023
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82321930
98GATA1_26923725_Chip-Seq_HPCs_Mouse0.79510981
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76611859
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.76156735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.65484000
2MP0008877_abnormal_DNA_methylation4.65023989
3MP0010094_abnormal_chromosome_stability4.57408670
4MP0003693_abnormal_embryo_hatching4.43982156
5MP0003111_abnormal_nucleus_morphology3.66579917
6MP0003941_abnormal_skin_development3.37384913
7MP0004957_abnormal_blastocyst_morpholog3.32457793
8MP0008007_abnormal_cellular_replicative3.06445808
9MP0008932_abnormal_embryonic_tissue2.85816367
10MP0003077_abnormal_cell_cycle2.82738543
11MP0002254_reproductive_system_inflammat2.82459753
12MP0003718_maternal_effect2.40100370
13MP0004147_increased_porphyrin_level2.29122679
14MP0003787_abnormal_imprinting2.13464851
15MP0003122_maternal_imprinting2.05045365
16MP0002102_abnormal_ear_morphology2.01785595
17MP0001529_abnormal_vocalization2.00296437
18MP0003786_premature_aging1.98108737
19MP0001730_embryonic_growth_arrest1.95278926
20MP0006072_abnormal_retinal_apoptosis1.88755463
21MP0009697_abnormal_copulation1.82097649
22MP0008057_abnormal_DNA_replication1.80553976
23MP0003121_genomic_imprinting1.78606608
24MP0009672_abnormal_birth_weight1.68644896
25MP0001188_hyperpigmentation1.64740659
26MP0003119_abnormal_digestive_system1.64085913
27MP0001293_anophthalmia1.63619527
28MP0002736_abnormal_nociception_after1.59926379
29MP0006292_abnormal_olfactory_placode1.58659625
30MP0006035_abnormal_mitochondrial_morpho1.54051157
31MP0003806_abnormal_nucleotide_metabolis1.47486064
32MP0010352_gastrointestinal_tract_polyps1.46679012
33MP0000350_abnormal_cell_proliferation1.42079143
34MP0003567_abnormal_fetal_cardiomyocyte1.41864240
35MP0003937_abnormal_limbs/digits/tail_de1.33514604
36MP0003011_delayed_dark_adaptation1.33142067
37MP0008789_abnormal_olfactory_epithelium1.32261923
38MP0003890_abnormal_embryonic-extraembry1.32090888
39MP0002751_abnormal_autonomic_nervous1.28989073
40MP0003315_abnormal_perineum_morphology1.28172801
41MP0002084_abnormal_developmental_patter1.26784501
42MP0005499_abnormal_olfactory_system1.26462340
43MP0005394_taste/olfaction_phenotype1.26462340
44MP0004133_heterotaxia1.26384460
45MP0006276_abnormal_autonomic_nervous1.24399720
46MP0003136_yellow_coat_color1.24082420
47MP0003186_abnormal_redox_activity1.22063759
48MP0003221_abnormal_cardiomyocyte_apopto1.20574817
49MP0002085_abnormal_embryonic_tissue1.19519570
50MP0001177_atelectasis1.15725815
51MP0001984_abnormal_olfaction1.14540306
52MP0005253_abnormal_eye_physiology1.13764921
53MP0001697_abnormal_embryo_size1.13759373
54MP0001672_abnormal_embryogenesis/_devel1.12240952
55MP0005380_embryogenesis_phenotype1.12240952
56MP0002090_abnormal_vision1.12093895
57MP0002080_prenatal_lethality1.08821451
58MP0004197_abnormal_fetal_growth/weight/1.03412842
59MP0005084_abnormal_gallbladder_morpholo1.03054806
60MP0000358_abnormal_cell_content/0.99859650
61MP0001286_abnormal_eye_development0.99173831
62MP0002938_white_spotting0.99002816
63MP0009703_decreased_birth_body0.97182883
64MP0000313_abnormal_cell_death0.94548542
65MP0006036_abnormal_mitochondrial_physio0.93295009
66MP0005395_other_phenotype0.92478487
67MP0001929_abnormal_gametogenesis0.91194606
68MP0003880_abnormal_central_pattern0.90052976
69MP0003984_embryonic_growth_retardation0.84472785
70MP0004782_abnormal_surfactant_physiolog0.83262864
71MP0002210_abnormal_sex_determination0.82273937
72MP0000653_abnormal_sex_gland0.80963622
73MP0002088_abnormal_embryonic_growth/wei0.80718179
74MP0001485_abnormal_pinna_reflex0.79422363
75MP0001764_abnormal_homeostasis0.79184034
76MP0000579_abnormal_nail_morphology0.78743088
77MP0001145_abnormal_male_reproductive0.77217314
78MP0000647_abnormal_sebaceous_gland0.76118668
79MP0005551_abnormal_eye_electrophysiolog0.76044027
80MP0000049_abnormal_middle_ear0.71243199
81MP0002111_abnormal_tail_morphology0.70984742
82MP0000516_abnormal_urinary_system0.70478399
83MP0005367_renal/urinary_system_phenotyp0.70478399
84MP0005391_vision/eye_phenotype0.69935422
85MP0001119_abnormal_female_reproductive0.69727836
86MP0002086_abnormal_extraembryonic_tissu0.69264082
87MP0002233_abnormal_nose_morphology0.68883059
88MP0002638_abnormal_pupillary_reflex0.65682739
89MP0003123_paternal_imprinting0.65334656
90MP0002697_abnormal_eye_size0.64780545
91MP0003698_abnormal_male_reproductive0.62351403
92MP0008872_abnormal_physiological_respon0.61806633
93MP0005248_abnormal_Harderian_gland0.61635852
94MP0002277_abnormal_respiratory_mucosa0.57780432
95MP0002653_abnormal_ependyma_morphology0.57416659
96MP0003861_abnormal_nervous_system0.56856264
97MP0008770_decreased_survivor_rate0.56715296
98MP0001299_abnormal_eye_distance/0.54491505
99MP0002161_abnormal_fertility/fecundity0.52790270
100MP0010307_abnormal_tumor_latency0.52653420

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)5.09356878
2Colon cancer (HP:0003003)4.12799095
3Abnormality of glycine metabolism (HP:0010895)3.64540410
4Abnormality of serine family amino acid metabolism (HP:0010894)3.64540410
5Abnormality of glycolysis (HP:0004366)3.54365501
6Abnormality of serum amino acid levels (HP:0003112)3.51934919
7Ependymoma (HP:0002888)3.32113968
8Increased serum pyruvate (HP:0003542)3.29290561
9Hyperglycinemia (HP:0002154)3.26932403
10Spastic diplegia (HP:0001264)3.13914955
11Multiple enchondromatosis (HP:0005701)3.02356331
12Microvesicular hepatic steatosis (HP:0001414)2.99571933
13Medulloblastoma (HP:0002885)2.96622800
14Postnatal microcephaly (HP:0005484)2.92282644
15Meckel diverticulum (HP:0002245)2.87437561
16Abnormal gallbladder physiology (HP:0012438)2.86867211
17Cholecystitis (HP:0001082)2.86867211
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.79256948
19Shoulder girdle muscle weakness (HP:0003547)2.74212282
20Neoplasm of the adrenal gland (HP:0100631)2.73002445
21Birth length less than 3rd percentile (HP:0003561)2.72972075
22Acute encephalopathy (HP:0006846)2.72856171
23Abnormality of the ileum (HP:0001549)2.71902915
24Acute necrotizing encephalopathy (HP:0006965)2.70239459
25Rhabdomyosarcoma (HP:0002859)2.68448839
26Hyperglycinuria (HP:0003108)2.64718698
27Abnormality of aspartate family amino acid metabolism (HP:0010899)2.63713192
28Abnormality of the hip-girdle musculature (HP:0001445)2.60663371
29Abnormality of the musculature of the pelvis (HP:0001469)2.60663371
30Cortical dysplasia (HP:0002539)2.59801081
31Abnormality of methionine metabolism (HP:0010901)2.57975295
32Increased hepatocellular lipid droplets (HP:0006565)2.51428090
33Chromsome breakage (HP:0040012)2.48886064
34Abnormality of the preputium (HP:0100587)2.47212197
35Glioma (HP:0009733)2.46506088
36Abolished electroretinogram (ERG) (HP:0000550)2.46395395
37Agnosia (HP:0010524)2.45281000
38Stenosis of the external auditory canal (HP:0000402)2.41505443
39Pelvic girdle muscle weakness (HP:0003749)2.37062681
40Abnormality of the astrocytes (HP:0100707)2.37001695
41Astrocytoma (HP:0009592)2.37001695
42Abnormal lung lobation (HP:0002101)2.36105730
43Nephroblastoma (Wilms tumor) (HP:0002667)2.34114062
44Abnormal mitochondria in muscle tissue (HP:0008316)2.33932987
45Methylmalonic acidemia (HP:0002912)2.30233457
46Abnormality of the pons (HP:0007361)2.29114674
47Abnormality of chromosome stability (HP:0003220)2.28113489
48Cerebral hypomyelination (HP:0006808)2.24519695
49Lipid accumulation in hepatocytes (HP:0006561)2.24267342
50Embryonal renal neoplasm (HP:0011794)2.23284094
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.22302623
52Broad foot (HP:0001769)2.19825159
53Hypoplasia of the pons (HP:0012110)2.19461331
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18311589
55Abnormality of alanine metabolism (HP:0010916)2.18311589
56Hyperalaninemia (HP:0003348)2.18311589
57Neoplasm of the colon (HP:0100273)2.15927283
58Cerebral edema (HP:0002181)2.14613717
59Increased CSF lactate (HP:0002490)2.14172670
60Abnormal hair whorl (HP:0010721)2.12610936
61Mitochondrial inheritance (HP:0001427)2.11830525
62Progressive macrocephaly (HP:0004481)2.11085155
63Small intestinal stenosis (HP:0012848)2.10836910
64Duodenal stenosis (HP:0100867)2.10836910
65Congenital primary aphakia (HP:0007707)2.10742139
66Type I transferrin isoform profile (HP:0003642)2.09174059
67Horseshoe kidney (HP:0000085)2.07165994
68Leukodystrophy (HP:0002415)2.06808296
69Bile duct proliferation (HP:0001408)2.06195560
70Abnormal biliary tract physiology (HP:0012439)2.06195560
71Abnormality of the metopic suture (HP:0005556)2.04835430
72Medial flaring of the eyebrow (HP:0010747)2.02219684
73Prominent metopic ridge (HP:0005487)2.01651168
74Sloping forehead (HP:0000340)2.01573790
75Aplasia/Hypoplasia of the sternum (HP:0006714)2.01029145
76Gait imbalance (HP:0002141)2.00464181
77Sensory axonal neuropathy (HP:0003390)1.96607509
78Nephrogenic diabetes insipidus (HP:0009806)1.95886777
79Increased serum lactate (HP:0002151)1.93539178
80Biliary tract neoplasm (HP:0100574)1.86659484
81Exercise-induced muscle cramps (HP:0003710)1.85199412
82Lactic acidosis (HP:0003128)1.84382782
83Methylmalonic aciduria (HP:0012120)1.83360816
84Optic nerve coloboma (HP:0000588)1.82654068
85Dandy-Walker malformation (HP:0001305)1.81645168
86Abnormality of the duodenum (HP:0002246)1.80568489
87Sensorimotor neuropathy (HP:0007141)1.79368343
88Neoplasm of the small intestine (HP:0100833)1.79166847
89Absent radius (HP:0003974)1.76101679
90Ovarian neoplasm (HP:0100615)1.75948617
91Large hands (HP:0001176)1.75301370
92Genital tract atresia (HP:0001827)1.74733404
93Pendular nystagmus (HP:0012043)1.73268229
94Pancreatic islet-cell hyperplasia (HP:0004510)1.71523690
95Vaginal atresia (HP:0000148)1.71192312
96Pancreatic cysts (HP:0001737)1.70999732
97Abnormality of the anterior horn cell (HP:0006802)1.69665170
98Degeneration of anterior horn cells (HP:0002398)1.69665170
99Aplasia involving forearm bones (HP:0009822)1.69113775
100Absent forearm bone (HP:0003953)1.69113775

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK65.15026972
2BUB14.49003735
3SRPK13.91001353
4TRIM283.03342915
5CDC72.94835555
6MKNK22.88174743
7TTK2.87845615
8TNIK2.87134864
9PLK32.78161465
10MKNK12.76701810
11NEK12.69849469
12ZAK2.61289202
13PBK2.50016098
14VRK22.31294579
15BCR2.07994184
16EIF2AK12.07366802
17WNK32.02647099
18MST41.86270207
19TAF11.73317581
20RPS6KA41.66983621
21PLK41.59311059
22NUAK11.59115798
23PLK11.58370385
24BCKDK1.50348067
25STK161.46818909
26VRK11.45705555
27EIF2AK31.44731871
28WEE11.43291283
29CSNK1G11.29888350
30ALK1.25641858
31CSNK1G31.19623898
32PASK1.16175584
33NME11.09665210
34MAP3K41.08489696
35CSNK1G21.06858316
36BRSK21.04170629
37ATR1.03983665
38CSNK1A1L0.99809663
39MAP4K20.98625707
40STK38L0.97686181
41DAPK10.93365616
42TIE10.92635383
43BRSK10.91961335
44EIF2AK20.85259119
45PLK20.84693286
46AURKB0.82976936
47BMPR1B0.79422512
48SIK30.73298336
49CDK90.72669127
50EPHA40.72467409
51DYRK20.71225021
52CHEK10.70431906
53CDK190.70408324
54CHEK20.67982092
55ATM0.67084969
56ERBB40.62092319
57ERBB30.60886095
58GRK10.60731983
59TGFBR10.60121519
60PDK20.58840506
61DYRK30.58815060
62PAK40.58520343
63CDK60.55206833
64RPS6KA50.53307206
65TLK10.53238815
66CSNK2A10.52771952
67FGFR10.50464378
68CDK70.50039334
69CSNK2A20.49321151
70MINK10.48314767
71STK40.47608439
72ACVR1B0.45367809
73CSNK1E0.43084458
74LIMK10.42899432
75PRKDC0.40413586
76AURKA0.40114533
77OXSR10.39802944
78CDK10.37454458
79CDK180.36764041
80MAP2K70.36300848
81CASK0.36179653
82CDK140.34523613
83CDK20.34406099
84PRKCG0.33638713
85UHMK10.33604815
86STK100.32620769
87MAP3K100.32612082
88STK240.31590240
89CSNK1A10.30527560
90FLT30.30227805
91CDK30.30009962
92MAP3K80.27851161
93CDK150.27095555
94PRKCI0.26516266
95CDK80.26196363
96BRD40.26101002
97CDK11A0.24038501
98CSNK1D0.22811522
99INSRR0.21925192
100NLK0.21583970

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.94984047
2Vitamin B6 metabolism_Homo sapiens_hsa007503.31882569
3Mismatch repair_Homo sapiens_hsa034303.19421868
4DNA replication_Homo sapiens_hsa030303.12144498
5Non-homologous end-joining_Homo sapiens_hsa034503.06747125
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.04429186
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.84321351
8RNA polymerase_Homo sapiens_hsa030202.39588605
9Protein export_Homo sapiens_hsa030602.38744691
10One carbon pool by folate_Homo sapiens_hsa006702.36418794
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.32856232
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.21184595
13Base excision repair_Homo sapiens_hsa034102.18409517
14Spliceosome_Homo sapiens_hsa030402.13165773
15Propanoate metabolism_Homo sapiens_hsa006402.11843431
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.11064420
17Cysteine and methionine metabolism_Homo sapiens_hsa002702.09704352
18RNA transport_Homo sapiens_hsa030132.09583881
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.04967665
20Biosynthesis of amino acids_Homo sapiens_hsa012302.02986490
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.99748316
22Homologous recombination_Homo sapiens_hsa034401.90867665
23Nucleotide excision repair_Homo sapiens_hsa034201.81556169
24Pyruvate metabolism_Homo sapiens_hsa006201.76033641
25Steroid biosynthesis_Homo sapiens_hsa001001.73055361
26Carbon metabolism_Homo sapiens_hsa012001.71087886
27RNA degradation_Homo sapiens_hsa030181.66444432
28Basal transcription factors_Homo sapiens_hsa030221.64830082
29Selenocompound metabolism_Homo sapiens_hsa004501.63291088
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.60268530
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56210916
32Cell cycle_Homo sapiens_hsa041101.53594254
33Pyrimidine metabolism_Homo sapiens_hsa002401.47651563
34Fanconi anemia pathway_Homo sapiens_hsa034601.44473786
35Fatty acid elongation_Homo sapiens_hsa000621.41971278
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30525090
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13471829
38Purine metabolism_Homo sapiens_hsa002301.13397953
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09626831
40mRNA surveillance pathway_Homo sapiens_hsa030151.09582911
41Parkinsons disease_Homo sapiens_hsa050121.04000573
42Oxidative phosphorylation_Homo sapiens_hsa001901.02667957
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98120061
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94764187
45Sulfur relay system_Homo sapiens_hsa041220.91953697
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91672501
47Arginine and proline metabolism_Homo sapiens_hsa003300.90408651
48Glutathione metabolism_Homo sapiens_hsa004800.84769422
49Huntingtons disease_Homo sapiens_hsa050160.81977936
50Fatty acid metabolism_Homo sapiens_hsa012120.81583532
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79883541
52Peroxisome_Homo sapiens_hsa041460.75676491
53Nitrogen metabolism_Homo sapiens_hsa009100.72848583
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72088979
55Oocyte meiosis_Homo sapiens_hsa041140.71157914
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70837284
57Fatty acid degradation_Homo sapiens_hsa000710.69954452
58beta-Alanine metabolism_Homo sapiens_hsa004100.67340995
59Metabolic pathways_Homo sapiens_hsa011000.64860708
60Butanoate metabolism_Homo sapiens_hsa006500.61553945
61Pentose phosphate pathway_Homo sapiens_hsa000300.60010881
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59454728
63Phototransduction_Homo sapiens_hsa047440.58194492
64Arginine biosynthesis_Homo sapiens_hsa002200.52515081
65Caffeine metabolism_Homo sapiens_hsa002320.47283175
66Alzheimers disease_Homo sapiens_hsa050100.43352229
67Tryptophan metabolism_Homo sapiens_hsa003800.42280472
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.41933679
69p53 signaling pathway_Homo sapiens_hsa041150.39987076
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38778204
71Nicotine addiction_Homo sapiens_hsa050330.37010404
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36413189
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34402809
74Fructose and mannose metabolism_Homo sapiens_hsa000510.33307203
75Fat digestion and absorption_Homo sapiens_hsa049750.32522368
76Folate biosynthesis_Homo sapiens_hsa007900.31186850
77Galactose metabolism_Homo sapiens_hsa000520.30515758
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29688538
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.29258173
80N-Glycan biosynthesis_Homo sapiens_hsa005100.28665900
81Lysine degradation_Homo sapiens_hsa003100.27268993
82Vitamin digestion and absorption_Homo sapiens_hsa049770.27102365
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26540598
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.25895697
85Tight junction_Homo sapiens_hsa045300.24806695
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23993293
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23952304
88Epstein-Barr virus infection_Homo sapiens_hsa051690.22669822
89Ribosome_Homo sapiens_hsa030100.22457419
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17553632
91Hippo signaling pathway_Homo sapiens_hsa043900.17447609
92Retinol metabolism_Homo sapiens_hsa008300.14311618
93Sulfur metabolism_Homo sapiens_hsa009200.13475424
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.13372837
95Legionellosis_Homo sapiens_hsa051340.11049505
96Wnt signaling pathway_Homo sapiens_hsa043100.10441969
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.08693171
98TGF-beta signaling pathway_Homo sapiens_hsa043500.08620530
99Starch and sucrose metabolism_Homo sapiens_hsa005000.07907419
100Fatty acid biosynthesis_Homo sapiens_hsa000610.07756399

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