

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | pyrimidine-containing compound transmembrane transport (GO:0072531) | 6.44716660 |
| 2 | L-serine metabolic process (GO:0006563) | 6.12298474 |
| 3 | vitamin transmembrane transport (GO:0035461) | 5.72254760 |
| 4 | water-soluble vitamin biosynthetic process (GO:0042364) | 5.23923546 |
| 5 | proteasome assembly (GO:0043248) | 4.97148081 |
| 6 | fucose catabolic process (GO:0019317) | 4.93334258 |
| 7 | L-fucose metabolic process (GO:0042354) | 4.93334258 |
| 8 | L-fucose catabolic process (GO:0042355) | 4.93334258 |
| 9 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 4.54188714 |
| 10 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 4.37356443 |
| 11 | respiratory chain complex IV assembly (GO:0008535) | 4.32426789 |
| 12 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 4.26971584 |
| 13 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 4.26151261 |
| 14 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 4.26151261 |
| 15 | negative regulation of telomere maintenance (GO:0032205) | 4.23925717 |
| 16 | DNA replication checkpoint (GO:0000076) | 4.11105201 |
| 17 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 4.04532906 |
| 18 | DNA double-strand break processing (GO:0000729) | 4.00404446 |
| 19 | serine family amino acid biosynthetic process (GO:0009070) | 3.94771040 |
| 20 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.89401627 |
| 21 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.89401627 |
| 22 | establishment of integrated proviral latency (GO:0075713) | 3.84681978 |
| 23 | chromatin remodeling at centromere (GO:0031055) | 3.76175100 |
| 24 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.76102552 |
| 25 | protein-cofactor linkage (GO:0018065) | 3.65333216 |
| 26 | cytochrome complex assembly (GO:0017004) | 3.65070848 |
| 27 | CENP-A containing nucleosome assembly (GO:0034080) | 3.61899911 |
| 28 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.60783042 |
| 29 | fucose metabolic process (GO:0006004) | 3.60213226 |
| 30 | regulation of regulatory T cell differentiation (GO:0045589) | 3.53092262 |
| 31 | maturation of SSU-rRNA (GO:0030490) | 3.49242642 |
| 32 | chaperone-mediated protein transport (GO:0072321) | 3.46709033 |
| 33 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.46143561 |
| 34 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.44060491 |
| 35 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.44060491 |
| 36 | telomere maintenance via telomerase (GO:0007004) | 3.43963178 |
| 37 | tRNA aminoacylation (GO:0043039) | 3.40036356 |
| 38 | amino acid activation (GO:0043038) | 3.40036356 |
| 39 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.38122017 |
| 40 | tRNA aminoacylation for protein translation (GO:0006418) | 3.37633086 |
| 41 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.37385980 |
| 42 | postreplication repair (GO:0006301) | 3.36801279 |
| 43 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.36558199 |
| 44 | negative regulation of ligase activity (GO:0051352) | 3.35614354 |
| 45 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.35614354 |
| 46 | iron ion import (GO:0097286) | 3.35144916 |
| 47 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.32487196 |
| 48 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.32110447 |
| 49 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.27561387 |
| 50 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.25980708 |
| 51 | fucosylation (GO:0036065) | 3.25105004 |
| 52 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.19851073 |
| 53 | negative regulation of DNA recombination (GO:0045910) | 3.17484657 |
| 54 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.17025549 |
| 55 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.17025549 |
| 56 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.17025549 |
| 57 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.11918784 |
| 58 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.11684042 |
| 59 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.11684042 |
| 60 | histone exchange (GO:0043486) | 3.11510276 |
| 61 | protein neddylation (GO:0045116) | 3.11500516 |
| 62 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.11408848 |
| 63 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.11313372 |
| 64 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.11313372 |
| 65 | isotype switching (GO:0045190) | 3.11313372 |
| 66 | regulation of immunoglobulin secretion (GO:0051023) | 3.06027377 |
| 67 | protein complex biogenesis (GO:0070271) | 3.05835872 |
| 68 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.05720290 |
| 69 | NADH dehydrogenase complex assembly (GO:0010257) | 3.05720290 |
| 70 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.05720290 |
| 71 | somatic diversification of immunoglobulins (GO:0016445) | 3.04031766 |
| 72 | GTP biosynthetic process (GO:0006183) | 3.03009008 |
| 73 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.01084137 |
| 74 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.01084137 |
| 75 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.97762067 |
| 76 | cullin deneddylation (GO:0010388) | 2.97670343 |
| 77 | spliceosomal snRNP assembly (GO:0000387) | 2.95186160 |
| 78 | RNA-dependent DNA replication (GO:0006278) | 2.95021735 |
| 79 | protein localization to kinetochore (GO:0034501) | 2.93549955 |
| 80 | intracellular protein transmembrane import (GO:0044743) | 2.92170532 |
| 81 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.92055673 |
| 82 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.92055673 |
| 83 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.91566494 |
| 84 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.91283074 |
| 85 | IMP biosynthetic process (GO:0006188) | 2.90998471 |
| 86 | protein deneddylation (GO:0000338) | 2.90112816 |
| 87 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.89922093 |
| 88 | termination of RNA polymerase III transcription (GO:0006386) | 2.89922093 |
| 89 | serine family amino acid metabolic process (GO:0009069) | 2.88748701 |
| 90 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.88535949 |
| 91 | ATP synthesis coupled proton transport (GO:0015986) | 2.88535949 |
| 92 | establishment of viral latency (GO:0019043) | 2.87937531 |
| 93 | cellular ketone body metabolic process (GO:0046950) | 2.86516580 |
| 94 | cysteine metabolic process (GO:0006534) | 2.86155493 |
| 95 | DNA strand elongation involved in DNA replication (GO:0006271) | 2.85629005 |
| 96 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.82951296 |
| 97 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.81938654 |
| 98 | positive regulation of ligase activity (GO:0051351) | 2.75727885 |
| 99 | 7-methylguanosine mRNA capping (GO:0006370) | 2.73533245 |
| 100 | IMP metabolic process (GO:0046040) | 2.71532486 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.86339889 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.76737185 |
| 3 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.35550816 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.46235330 |
| 5 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.17365204 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.14155613 |
| 7 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.02817218 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.81956333 |
| 9 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.68420228 |
| 10 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.64722808 |
| 11 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.60004439 |
| 12 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.57825467 |
| 13 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.54685050 |
| 14 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.41734768 |
| 15 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.39696978 |
| 16 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.36959918 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.34758196 |
| 18 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.34184808 |
| 19 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.29050844 |
| 20 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.18198655 |
| 21 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 2.18124656 |
| 22 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.03618755 |
| 23 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.93335375 |
| 24 | VDR_22108803_ChIP-Seq_LS180_Human | 1.86783673 |
| 25 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.82774090 |
| 26 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.81282459 |
| 27 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.81093317 |
| 28 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.80627379 |
| 29 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.73600088 |
| 30 | EWS_26573619_Chip-Seq_HEK293_Human | 1.73530412 |
| 31 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.69940192 |
| 32 | GATA1_22025678_ChIP-Seq_K562_Human | 1.69253805 |
| 33 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.68483100 |
| 34 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.64562868 |
| 35 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.61909009 |
| 36 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.59277319 |
| 37 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.56316341 |
| 38 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.56184120 |
| 39 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.56003374 |
| 40 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.55382456 |
| 41 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.53616208 |
| 42 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.51260843 |
| 43 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.51171885 |
| 44 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.50372164 |
| 45 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.49798902 |
| 46 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.49614639 |
| 47 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.48234125 |
| 48 | P300_19829295_ChIP-Seq_ESCs_Human | 1.48077522 |
| 49 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.47389161 |
| 50 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.41531816 |
| 51 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.38575463 |
| 52 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.36812852 |
| 53 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.35375801 |
| 54 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.33987831 |
| 55 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.33462427 |
| 56 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.31771102 |
| 57 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.29684962 |
| 58 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.29459327 |
| 59 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.28625856 |
| 60 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.25594397 |
| 61 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.23093197 |
| 62 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.21213127 |
| 63 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.21102543 |
| 64 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.20939887 |
| 65 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.19999049 |
| 66 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.19770253 |
| 67 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.19695809 |
| 68 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.18021582 |
| 69 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.17834985 |
| 70 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.16459706 |
| 71 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.13499396 |
| 72 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.10644325 |
| 73 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.09489323 |
| 74 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.08200731 |
| 75 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.07007243 |
| 76 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.07007243 |
| 77 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.06542239 |
| 78 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.05866114 |
| 79 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.04146772 |
| 80 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.01364500 |
| 81 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.00107851 |
| 82 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.98647673 |
| 83 | FUS_26573619_Chip-Seq_HEK293_Human | 0.96384440 |
| 84 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.96049812 |
| 85 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.93439552 |
| 86 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.92453238 |
| 87 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.91656128 |
| 88 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.91136457 |
| 89 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.90879164 |
| 90 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.90879164 |
| 91 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.90254530 |
| 92 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.89909234 |
| 93 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.88996370 |
| 94 | EZH2_22144423_ChIP-Seq_EOC_Human | 0.88617500 |
| 95 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.88159373 |
| 96 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.85658687 |
| 97 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.85658687 |
| 98 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.85658687 |
| 99 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.84921648 |
| 100 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.84187646 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004147_increased_porphyrin_level | 5.88558968 |
| 2 | MP0003195_calcinosis | 4.63905125 |
| 3 | MP0003136_yellow_coat_color | 4.18093410 |
| 4 | MP0008877_abnormal_DNA_methylation | 3.62692133 |
| 5 | MP0008058_abnormal_DNA_repair | 3.07727285 |
| 6 | MP0003718_maternal_effect | 3.06060156 |
| 7 | MP0010094_abnormal_chromosome_stability | 3.00404817 |
| 8 | MP0002653_abnormal_ependyma_morphology | 2.57241406 |
| 9 | MP0003941_abnormal_skin_development | 2.46241697 |
| 10 | MP0002102_abnormal_ear_morphology | 2.46121506 |
| 11 | MP0003693_abnormal_embryo_hatching | 2.42925970 |
| 12 | MP0000465_gastrointestinal_hemorrhage | 2.31743322 |
| 13 | MP0001529_abnormal_vocalization | 2.24244827 |
| 14 | MP0003011_delayed_dark_adaptation | 2.14224193 |
| 15 | MP0006292_abnormal_olfactory_placode | 2.06860579 |
| 16 | MP0001501_abnormal_sleep_pattern | 2.03727091 |
| 17 | MP0002254_reproductive_system_inflammat | 1.85815917 |
| 18 | MP0002277_abnormal_respiratory_mucosa | 1.82468375 |
| 19 | MP0008875_abnormal_xenobiotic_pharmacok | 1.81115530 |
| 20 | MP0003786_premature_aging | 1.79623031 |
| 21 | MP0003111_abnormal_nucleus_morphology | 1.78919930 |
| 22 | MP0001485_abnormal_pinna_reflex | 1.69596793 |
| 23 | MP0001188_hyperpigmentation | 1.68586710 |
| 24 | MP0001486_abnormal_startle_reflex | 1.65751594 |
| 25 | MP0004957_abnormal_blastocyst_morpholog | 1.63239392 |
| 26 | MP0001293_anophthalmia | 1.60837197 |
| 27 | MP0002736_abnormal_nociception_after | 1.60410926 |
| 28 | MP0006072_abnormal_retinal_apoptosis | 1.57271567 |
| 29 | MP0000372_irregular_coat_pigmentation | 1.56481657 |
| 30 | MP0004742_abnormal_vestibular_system | 1.47611978 |
| 31 | MP0001853_heart_inflammation | 1.46210553 |
| 32 | MP0005670_abnormal_white_adipose | 1.45698378 |
| 33 | MP0002090_abnormal_vision | 1.44954628 |
| 34 | MP0009697_abnormal_copulation | 1.43907297 |
| 35 | MP0005551_abnormal_eye_electrophysiolog | 1.43035570 |
| 36 | MP0009745_abnormal_behavioral_response | 1.38666972 |
| 37 | MP0006276_abnormal_autonomic_nervous | 1.38475604 |
| 38 | MP0003567_abnormal_fetal_cardiomyocyte | 1.38102915 |
| 39 | MP0008932_abnormal_embryonic_tissue | 1.37903978 |
| 40 | MP0002163_abnormal_gland_morphology | 1.36771832 |
| 41 | MP0003119_abnormal_digestive_system | 1.32767896 |
| 42 | MP0002210_abnormal_sex_determination | 1.29802118 |
| 43 | MP0005187_abnormal_penis_morphology | 1.29641280 |
| 44 | MP0005395_other_phenotype | 1.29322851 |
| 45 | MP0000647_abnormal_sebaceous_gland | 1.28645028 |
| 46 | MP0004133_heterotaxia | 1.26390570 |
| 47 | MP0008007_abnormal_cellular_replicative | 1.26064499 |
| 48 | MP0004885_abnormal_endolymph | 1.25610804 |
| 49 | MP0003077_abnormal_cell_cycle | 1.23463585 |
| 50 | MP0001764_abnormal_homeostasis | 1.23286381 |
| 51 | MP0008057_abnormal_DNA_replication | 1.21000788 |
| 52 | MP0000604_amyloidosis | 1.20055672 |
| 53 | MP0002751_abnormal_autonomic_nervous | 1.19551228 |
| 54 | MP0002160_abnormal_reproductive_system | 1.16900682 |
| 55 | MP0005253_abnormal_eye_physiology | 1.09129572 |
| 56 | MP0006035_abnormal_mitochondrial_morpho | 1.09095963 |
| 57 | MP0008872_abnormal_physiological_respon | 1.05338713 |
| 58 | MP0001119_abnormal_female_reproductive | 1.05207183 |
| 59 | MP0006036_abnormal_mitochondrial_physio | 1.01305064 |
| 60 | MP0000653_abnormal_sex_gland | 0.99481691 |
| 61 | MP0003656_abnormal_erythrocyte_physiolo | 0.97067819 |
| 62 | MP0003186_abnormal_redox_activity | 0.96657839 |
| 63 | MP0002132_abnormal_respiratory_system | 0.95563293 |
| 64 | MP0001929_abnormal_gametogenesis | 0.93430082 |
| 65 | MP0002938_white_spotting | 0.93030652 |
| 66 | MP0003315_abnormal_perineum_morphology | 0.91747799 |
| 67 | MP0005084_abnormal_gallbladder_morpholo | 0.87265095 |
| 68 | MP0004215_abnormal_myocardial_fiber | 0.87173097 |
| 69 | MP0001145_abnormal_male_reproductive | 0.87015686 |
| 70 | MP0003137_abnormal_impulse_conducting | 0.84849042 |
| 71 | MP0005379_endocrine/exocrine_gland_phen | 0.84152620 |
| 72 | MP0009046_muscle_twitch | 0.83366696 |
| 73 | MP0004142_abnormal_muscle_tone | 0.81911804 |
| 74 | MP0005167_abnormal_blood-brain_barrier | 0.81800768 |
| 75 | MP0005389_reproductive_system_phenotype | 0.81233293 |
| 76 | MP0003937_abnormal_limbs/digits/tail_de | 0.78642673 |
| 77 | MP0003806_abnormal_nucleotide_metabolis | 0.78412254 |
| 78 | MP0001730_embryonic_growth_arrest | 0.77175241 |
| 79 | MP0000749_muscle_degeneration | 0.76032782 |
| 80 | MP0002638_abnormal_pupillary_reflex | 0.75814337 |
| 81 | MP0004782_abnormal_surfactant_physiolog | 0.72327230 |
| 82 | MP0005332_abnormal_amino_acid | 0.70728753 |
| 83 | MP0003936_abnormal_reproductive_system | 0.70657447 |
| 84 | MP0003699_abnormal_female_reproductive | 0.70273067 |
| 85 | MP0005266_abnormal_metabolism | 0.70267061 |
| 86 | MP0001177_atelectasis | 0.68907102 |
| 87 | MP0009672_abnormal_birth_weight | 0.68142652 |
| 88 | MP0004043_abnormal_pH_regulation | 0.66796063 |
| 89 | MP0003698_abnormal_male_reproductive | 0.66714403 |
| 90 | MP0004924_abnormal_behavior | 0.65675406 |
| 91 | MP0005386_behavior/neurological_phenoty | 0.65675406 |
| 92 | MP0001968_abnormal_touch/_nociception | 0.64719555 |
| 93 | MP0009384_cardiac_valve_regurgitation | 0.64709902 |
| 94 | MP0002272_abnormal_nervous_system | 0.63288760 |
| 95 | MP0000631_abnormal_neuroendocrine_gland | 0.60808555 |
| 96 | MP0002837_dystrophic_cardiac_calcinosis | 0.60711639 |
| 97 | MP0002572_abnormal_emotion/affect_behav | 0.60268977 |
| 98 | MP0002111_abnormal_tail_morphology | 0.59124377 |
| 99 | MP0005248_abnormal_Harderian_gland | 0.58519183 |
| 100 | MP0000049_abnormal_middle_ear | 0.57843631 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Mutism (HP:0002300) | 4.48060768 |
| 2 | Inability to walk (HP:0002540) | 4.23081008 |
| 3 | Confusion (HP:0001289) | 4.00957723 |
| 4 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.87815678 |
| 5 | Birth length less than 3rd percentile (HP:0003561) | 3.76000012 |
| 6 | Concave nail (HP:0001598) | 3.67527979 |
| 7 | Chromsome breakage (HP:0040012) | 3.28144588 |
| 8 | Meckel diverticulum (HP:0002245) | 3.23772156 |
| 9 | Sensory axonal neuropathy (HP:0003390) | 3.15929140 |
| 10 | Colon cancer (HP:0003003) | 3.14616850 |
| 11 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.10617801 |
| 12 | Abnormality of the labia minora (HP:0012880) | 3.09060014 |
| 13 | Abnormality of the ileum (HP:0001549) | 3.08455302 |
| 14 | Reticulocytopenia (HP:0001896) | 3.00419506 |
| 15 | Congenital, generalized hypertrichosis (HP:0004540) | 2.89770205 |
| 16 | Acute necrotizing encephalopathy (HP:0006965) | 2.88589805 |
| 17 | Abnormal number of erythroid precursors (HP:0012131) | 2.87872076 |
| 18 | Abnormality of alanine metabolism (HP:0010916) | 2.86783542 |
| 19 | Hyperalaninemia (HP:0003348) | 2.86783542 |
| 20 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.86783542 |
| 21 | Abnormal biliary tract physiology (HP:0012439) | 2.82238789 |
| 22 | Bile duct proliferation (HP:0001408) | 2.82238789 |
| 23 | Acute encephalopathy (HP:0006846) | 2.80594442 |
| 24 | Abnormality of the preputium (HP:0100587) | 2.79366182 |
| 25 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.79237080 |
| 26 | Increased hepatocellular lipid droplets (HP:0006565) | 2.78084893 |
| 27 | Methylmalonic acidemia (HP:0002912) | 2.77515500 |
| 28 | Pancreatic cysts (HP:0001737) | 2.76895085 |
| 29 | Progressive inability to walk (HP:0002505) | 2.71823349 |
| 30 | Abnormality of chromosome stability (HP:0003220) | 2.71749276 |
| 31 | Lipid accumulation in hepatocytes (HP:0006561) | 2.66714190 |
| 32 | Abnormality of serum amino acid levels (HP:0003112) | 2.63246743 |
| 33 | True hermaphroditism (HP:0010459) | 2.62947818 |
| 34 | Mitochondrial inheritance (HP:0001427) | 2.61322116 |
| 35 | Abnormality of midbrain morphology (HP:0002418) | 2.59206684 |
| 36 | Molar tooth sign on MRI (HP:0002419) | 2.59206684 |
| 37 | Nephronophthisis (HP:0000090) | 2.52836493 |
| 38 | Cerebral hypomyelination (HP:0006808) | 2.51464072 |
| 39 | Triphalangeal thumb (HP:0001199) | 2.50901820 |
| 40 | Duplicated collecting system (HP:0000081) | 2.50533177 |
| 41 | Increased CSF lactate (HP:0002490) | 2.47339848 |
| 42 | Paraparesis (HP:0002385) | 2.46291621 |
| 43 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.45283309 |
| 44 | Pancreatic fibrosis (HP:0100732) | 2.42615850 |
| 45 | Abnormality of the pons (HP:0007361) | 2.33137725 |
| 46 | Hypoplasia of the pons (HP:0012110) | 2.32141718 |
| 47 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.31786751 |
| 48 | Decreased central vision (HP:0007663) | 2.31062987 |
| 49 | Tubular atrophy (HP:0000092) | 2.30492363 |
| 50 | Abnormality of glycine metabolism (HP:0010895) | 2.29086782 |
| 51 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.29086782 |
| 52 | Absent thumb (HP:0009777) | 2.25173214 |
| 53 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.24862279 |
| 54 | Methylmalonic aciduria (HP:0012120) | 2.24240079 |
| 55 | Hepatocellular necrosis (HP:0001404) | 2.24051513 |
| 56 | Optic nerve hypoplasia (HP:0000609) | 2.23856199 |
| 57 | Oral leukoplakia (HP:0002745) | 2.22988335 |
| 58 | Dyschromatopsia (HP:0007641) | 2.22737505 |
| 59 | Increased serum lactate (HP:0002151) | 2.21907343 |
| 60 | Progressive macrocephaly (HP:0004481) | 2.20714898 |
| 61 | Microvesicular hepatic steatosis (HP:0001414) | 2.19850131 |
| 62 | Abnormality of the renal collecting system (HP:0004742) | 2.19832293 |
| 63 | Aplastic anemia (HP:0001915) | 2.18366895 |
| 64 | Lactic acidosis (HP:0003128) | 2.16410461 |
| 65 | Hepatic necrosis (HP:0002605) | 2.16314099 |
| 66 | Duodenal stenosis (HP:0100867) | 2.16118424 |
| 67 | Small intestinal stenosis (HP:0012848) | 2.16118424 |
| 68 | Horseshoe kidney (HP:0000085) | 2.14200534 |
| 69 | Type II lissencephaly (HP:0007260) | 2.13394780 |
| 70 | Hyperglycinemia (HP:0002154) | 2.11602425 |
| 71 | Abolished electroretinogram (ERG) (HP:0000550) | 2.09927232 |
| 72 | Cerebral edema (HP:0002181) | 2.07035263 |
| 73 | Respiratory difficulties (HP:0002880) | 2.05156116 |
| 74 | External ophthalmoplegia (HP:0000544) | 2.04150659 |
| 75 | Testicular atrophy (HP:0000029) | 2.02697241 |
| 76 | Sloping forehead (HP:0000340) | 2.02008543 |
| 77 | Abnormality of the carotid arteries (HP:0005344) | 1.98736596 |
| 78 | Abnormality of homocysteine metabolism (HP:0010919) | 1.96277051 |
| 79 | Homocystinuria (HP:0002156) | 1.96277051 |
| 80 | Clubbing of toes (HP:0100760) | 1.96178804 |
| 81 | Increased intramyocellular lipid droplets (HP:0012240) | 1.94815017 |
| 82 | Brittle hair (HP:0002299) | 1.94211017 |
| 83 | CNS hypomyelination (HP:0003429) | 1.91060120 |
| 84 | Septo-optic dysplasia (HP:0100842) | 1.87190692 |
| 85 | Dandy-Walker malformation (HP:0001305) | 1.85061806 |
| 86 | Pancytopenia (HP:0001876) | 1.83253360 |
| 87 | Hypophosphatemic rickets (HP:0004912) | 1.82878723 |
| 88 | Duplication of thumb phalanx (HP:0009942) | 1.81350161 |
| 89 | Increased serum pyruvate (HP:0003542) | 1.80908654 |
| 90 | Abnormal hair whorl (HP:0010721) | 1.80029558 |
| 91 | Cerebral hemorrhage (HP:0001342) | 1.78666119 |
| 92 | Severe muscular hypotonia (HP:0006829) | 1.76139183 |
| 93 | Furrowed tongue (HP:0000221) | 1.75111201 |
| 94 | Abnormality of the duodenum (HP:0002246) | 1.74711350 |
| 95 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.74303326 |
| 96 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.74303326 |
| 97 | Large for gestational age (HP:0001520) | 1.74259666 |
| 98 | Lethargy (HP:0001254) | 1.73489146 |
| 99 | Increased muscle lipid content (HP:0009058) | 1.72984658 |
| 100 | Absent radius (HP:0003974) | 1.72794556 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ZAK | 3.97092493 |
| 2 | BUB1 | 3.19376196 |
| 3 | VRK2 | 3.04933374 |
| 4 | ADRBK2 | 3.01435408 |
| 5 | TSSK6 | 2.69461450 |
| 6 | PAK4 | 2.54056009 |
| 7 | VRK1 | 2.47010092 |
| 8 | TRIM28 | 2.40987004 |
| 9 | MST4 | 2.26917603 |
| 10 | BCKDK | 2.26653487 |
| 11 | WNK3 | 2.24281159 |
| 12 | SRPK1 | 1.99505907 |
| 13 | PLK3 | 1.90006558 |
| 14 | TLK1 | 1.89902731 |
| 15 | MKNK1 | 1.87997367 |
| 16 | CDC7 | 1.85371533 |
| 17 | BCR | 1.80335639 |
| 18 | MKNK2 | 1.73815045 |
| 19 | PBK | 1.68858768 |
| 20 | NUAK1 | 1.55468862 |
| 21 | TNIK | 1.52247833 |
| 22 | DYRK2 | 1.51871542 |
| 23 | MAP3K4 | 1.50670021 |
| 24 | GRK1 | 1.48898675 |
| 25 | TIE1 | 1.48560588 |
| 26 | TXK | 1.48550782 |
| 27 | SIK3 | 1.46592660 |
| 28 | BMPR1B | 1.45690161 |
| 29 | TTK | 1.44024649 |
| 30 | WNK4 | 1.40782262 |
| 31 | EIF2AK1 | 1.35871875 |
| 32 | KDR | 1.34811119 |
| 33 | NME1 | 1.33447850 |
| 34 | CSNK1G1 | 1.30505315 |
| 35 | OXSR1 | 1.30142244 |
| 36 | NEK1 | 1.29738019 |
| 37 | PLK1 | 1.28194168 |
| 38 | BRSK2 | 1.24056642 |
| 39 | TAF1 | 1.23472073 |
| 40 | WEE1 | 1.23245531 |
| 41 | CSNK1G3 | 1.22326107 |
| 42 | CSNK1G2 | 1.21225922 |
| 43 | EIF2AK3 | 1.19185363 |
| 44 | CSNK1A1L | 1.18205123 |
| 45 | ACVR1B | 1.04969678 |
| 46 | PINK1 | 1.02759945 |
| 47 | ALK | 1.00993616 |
| 48 | MAP3K12 | 0.94857299 |
| 49 | TGFBR1 | 0.93247524 |
| 50 | CDK8 | 0.91133058 |
| 51 | CDK19 | 0.89622806 |
| 52 | PASK | 0.88211969 |
| 53 | ATR | 0.86911011 |
| 54 | DAPK2 | 0.86665866 |
| 55 | DYRK3 | 0.81950982 |
| 56 | STK16 | 0.81645339 |
| 57 | BRSK1 | 0.81247010 |
| 58 | PLK2 | 0.80546115 |
| 59 | DAPK1 | 0.79944871 |
| 60 | ERBB3 | 0.78682787 |
| 61 | RPS6KA5 | 0.76765832 |
| 62 | DYRK1A | 0.76625110 |
| 63 | PDK2 | 0.67967368 |
| 64 | MAP4K2 | 0.67755378 |
| 65 | EPHA4 | 0.67302081 |
| 66 | PLK4 | 0.66488940 |
| 67 | MAPK13 | 0.65949655 |
| 68 | PRKD3 | 0.65885104 |
| 69 | LIMK1 | 0.60180983 |
| 70 | ABL2 | 0.55021769 |
| 71 | CSNK2A1 | 0.54992754 |
| 72 | ADRBK1 | 0.54536515 |
| 73 | STK39 | 0.54373827 |
| 74 | AURKB | 0.50456081 |
| 75 | CAMKK2 | 0.48693387 |
| 76 | RPS6KA4 | 0.48535033 |
| 77 | MAPKAPK3 | 0.48373707 |
| 78 | AKT2 | 0.48049443 |
| 79 | ATM | 0.47620478 |
| 80 | MAP2K6 | 0.46053702 |
| 81 | FER | 0.45135451 |
| 82 | TEC | 0.43848689 |
| 83 | CSNK2A2 | 0.43678787 |
| 84 | CAMK1 | 0.37263083 |
| 85 | OBSCN | 0.37004462 |
| 86 | INSRR | 0.36639942 |
| 87 | PRKCQ | 0.35508267 |
| 88 | DAPK3 | 0.35434342 |
| 89 | CDK18 | 0.35291727 |
| 90 | EIF2AK2 | 0.34285136 |
| 91 | PRKCE | 0.34117858 |
| 92 | STK4 | 0.32954614 |
| 93 | NLK | 0.32401770 |
| 94 | PKN1 | 0.31739353 |
| 95 | CAMK2A | 0.31671396 |
| 96 | CDK9 | 0.30929604 |
| 97 | CHEK2 | 0.29231901 |
| 98 | CDK14 | 0.29011407 |
| 99 | MAPKAPK5 | 0.28284928 |
| 100 | FRK | 0.28056430 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 3.99832901 |
| 2 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 3.41626319 |
| 3 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 3.09487490 |
| 4 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.55117730 |
| 5 | Homologous recombination_Homo sapiens_hsa03440 | 2.47856152 |
| 6 | Protein export_Homo sapiens_hsa03060 | 2.38103652 |
| 7 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.35286233 |
| 8 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.31620475 |
| 9 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.22282729 |
| 10 | RNA polymerase_Homo sapiens_hsa03020 | 2.21404703 |
| 11 | Basal transcription factors_Homo sapiens_hsa03022 | 2.20338704 |
| 12 | Mismatch repair_Homo sapiens_hsa03430 | 2.17714553 |
| 13 | DNA replication_Homo sapiens_hsa03030 | 2.04770407 |
| 14 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.04332944 |
| 15 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.99911625 |
| 16 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.99449707 |
| 17 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.91211489 |
| 18 | Parkinsons disease_Homo sapiens_hsa05012 | 1.86939689 |
| 19 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.85456506 |
| 20 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.77433482 |
| 21 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.75600528 |
| 22 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.74662950 |
| 23 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.72461297 |
| 24 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.65157810 |
| 25 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.59465767 |
| 26 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.55772840 |
| 27 | Phototransduction_Homo sapiens_hsa04744 | 1.50641534 |
| 28 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.50315475 |
| 29 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.47092026 |
| 30 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.46653709 |
| 31 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.46029498 |
| 32 | RNA degradation_Homo sapiens_hsa03018 | 1.45149205 |
| 33 | RNA transport_Homo sapiens_hsa03013 | 1.43473739 |
| 34 | Base excision repair_Homo sapiens_hsa03410 | 1.38385166 |
| 35 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.38268497 |
| 36 | Huntingtons disease_Homo sapiens_hsa05016 | 1.34515450 |
| 37 | Ribosome_Homo sapiens_hsa03010 | 1.33317413 |
| 38 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.30799131 |
| 39 | Spliceosome_Homo sapiens_hsa03040 | 1.28417208 |
| 40 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.28211209 |
| 41 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.27685223 |
| 42 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.13815470 |
| 43 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.11608633 |
| 44 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.11381885 |
| 45 | Peroxisome_Homo sapiens_hsa04146 | 1.07320070 |
| 46 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.06516990 |
| 47 | Alzheimers disease_Homo sapiens_hsa05010 | 1.03903908 |
| 48 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.03641662 |
| 49 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.01760809 |
| 50 | Purine metabolism_Homo sapiens_hsa00230 | 1.01446022 |
| 51 | Sulfur relay system_Homo sapiens_hsa04122 | 1.00834154 |
| 52 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.96670203 |
| 53 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.95659682 |
| 54 | Carbon metabolism_Homo sapiens_hsa01200 | 0.93607739 |
| 55 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.88855939 |
| 56 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.87058168 |
| 57 | Cell cycle_Homo sapiens_hsa04110 | 0.81333634 |
| 58 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.76605577 |
| 59 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.76454421 |
| 60 | Alcoholism_Homo sapiens_hsa05034 | 0.76161773 |
| 61 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.73074243 |
| 62 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.71115348 |
| 63 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.68759528 |
| 64 | Metabolic pathways_Homo sapiens_hsa01100 | 0.67493933 |
| 65 | Taste transduction_Homo sapiens_hsa04742 | 0.65145109 |
| 66 | Retinol metabolism_Homo sapiens_hsa00830 | 0.61708687 |
| 67 | Histidine metabolism_Homo sapiens_hsa00340 | 0.61450911 |
| 68 | Nicotine addiction_Homo sapiens_hsa05033 | 0.60915297 |
| 69 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.59180702 |
| 70 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.58104900 |
| 71 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.53466007 |
| 72 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.50463330 |
| 73 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.48885535 |
| 74 | Circadian rhythm_Homo sapiens_hsa04710 | 0.48745542 |
| 75 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.47543007 |
| 76 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.46484363 |
| 77 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.45958948 |
| 78 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.45618257 |
| 79 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.45539966 |
| 80 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.43587987 |
| 81 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.43518407 |
| 82 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.42779542 |
| 83 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.36942321 |
| 84 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.36903530 |
| 85 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.36659419 |
| 86 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.36622298 |
| 87 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.35805911 |
| 88 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.31479864 |
| 89 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.31169330 |
| 90 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.31002744 |
| 91 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.30817310 |
| 92 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.30527815 |
| 93 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.28805863 |
| 94 | Mineral absorption_Homo sapiens_hsa04978 | 0.25237904 |
| 95 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.20927292 |
| 96 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.19249364 |
| 97 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.18700347 |
| 98 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.18656695 |
| 99 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.17537281 |
| 100 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.17180252 |

