PSD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.71311013
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.48246717
3locomotory exploration behavior (GO:0035641)6.47988928
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.28354956
5vocalization behavior (GO:0071625)5.74590153
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.71398706
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.66495414
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.43028404
9regulation of glutamate receptor signaling pathway (GO:1900449)5.34639213
10synaptic vesicle exocytosis (GO:0016079)5.32739062
11glutamate secretion (GO:0014047)5.21134247
12regulation of synapse structural plasticity (GO:0051823)5.20797249
13regulation of synaptic vesicle exocytosis (GO:2000300)5.08664157
14regulation of neuronal synaptic plasticity (GO:0048168)4.94013480
15protein localization to synapse (GO:0035418)4.93609084
16L-amino acid import (GO:0043092)4.92787677
17exploration behavior (GO:0035640)4.92071729
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.88275491
19layer formation in cerebral cortex (GO:0021819)4.78249737
20dendritic spine morphogenesis (GO:0060997)4.74822240
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.59561387
22regulation of synaptic vesicle transport (GO:1902803)4.54301610
23neurotransmitter-gated ion channel clustering (GO:0072578)4.50561053
24neurotransmitter secretion (GO:0007269)4.45512024
25cerebellar granule cell differentiation (GO:0021707)4.45185289
26amino acid import (GO:0043090)4.40782874
27regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.32777635
28synaptic transmission, glutamatergic (GO:0035249)4.22194918
29positive regulation of membrane potential (GO:0045838)4.16421825
30regulation of dendritic spine morphogenesis (GO:0061001)4.13760813
31neuron cell-cell adhesion (GO:0007158)4.13569579
32long-term memory (GO:0007616)4.11427942
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.10030512
34negative regulation of synaptic transmission, GABAergic (GO:0032229)4.09539567
35neuronal action potential propagation (GO:0019227)4.03579524
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.02850417
37regulation of excitatory postsynaptic membrane potential (GO:0060079)4.01278159
38axon ensheathment in central nervous system (GO:0032291)3.94802361
39central nervous system myelination (GO:0022010)3.94802361
40potassium ion homeostasis (GO:0055075)3.92610439
41glutamate receptor signaling pathway (GO:0007215)3.90286832
42neuron-neuron synaptic transmission (GO:0007270)3.89079887
43proline transport (GO:0015824)3.87080667
44neuromuscular process controlling balance (GO:0050885)3.84274582
45regulation of synapse maturation (GO:0090128)3.84200928
46gamma-aminobutyric acid transport (GO:0015812)3.81019135
47regulation of synaptic plasticity (GO:0048167)3.80863675
48auditory behavior (GO:0031223)3.79034475
49negative regulation of dendrite morphogenesis (GO:0050774)3.77655006
50positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.76886327
51positive regulation of synapse maturation (GO:0090129)3.74879889
52regulation of postsynaptic membrane potential (GO:0060078)3.74389195
53activation of protein kinase A activity (GO:0034199)3.73311538
54potassium ion import (GO:0010107)3.72640966
55G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.70623999
56positive regulation of synaptic transmission, GABAergic (GO:0032230)3.70106285
57prepulse inhibition (GO:0060134)3.65572190
58cellular potassium ion homeostasis (GO:0030007)3.57707471
59positive regulation of neurotransmitter transport (GO:0051590)3.54410107
60positive regulation of neurotransmitter secretion (GO:0001956)3.54211167
61response to auditory stimulus (GO:0010996)3.51777580
62dendritic spine organization (GO:0097061)3.51146241
63positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.49306408
64sodium ion export (GO:0071436)3.48721979
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46623482
66regulation of neurotransmitter secretion (GO:0046928)3.45957422
67neurotransmitter transport (GO:0006836)3.44582948
68positive regulation of dendritic spine development (GO:0060999)3.44301695
69regulation of dendritic spine development (GO:0060998)3.43498911
70dendrite morphogenesis (GO:0048813)3.42266424
71transmission of nerve impulse (GO:0019226)3.39863504
72long-term synaptic potentiation (GO:0060291)3.38091194
73acidic amino acid transport (GO:0015800)3.37179426
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.35872849
75neuron recognition (GO:0008038)3.34933731
76postsynaptic membrane organization (GO:0001941)3.32683583
77positive regulation of dendritic spine morphogenesis (GO:0061003)3.32583122
78regulation of female receptivity (GO:0045924)3.30129914
79synaptic vesicle endocytosis (GO:0048488)3.29155159
80gamma-aminobutyric acid signaling pathway (GO:0007214)3.28317824
81neuromuscular synaptic transmission (GO:0007274)3.27403644
82neuronal ion channel clustering (GO:0045161)3.26979832
83cellular sodium ion homeostasis (GO:0006883)3.26955487
84regulation of neurotransmitter levels (GO:0001505)3.24861701
85regulation of vesicle fusion (GO:0031338)3.22467196
86regulation of neurotransmitter transport (GO:0051588)3.22079919
87vesicle docking involved in exocytosis (GO:0006904)3.17843416
88cytoskeletal anchoring at plasma membrane (GO:0007016)3.17537909
89dopamine receptor signaling pathway (GO:0007212)3.16929683
90synaptic transmission (GO:0007268)3.15874394
91glycine transport (GO:0015816)3.15348216
92learning (GO:0007612)3.14831392
93membrane depolarization (GO:0051899)3.14436753
94cell migration in hindbrain (GO:0021535)3.14411130
95behavioral defense response (GO:0002209)3.13911937
96behavioral fear response (GO:0001662)3.13911937
97axonal fasciculation (GO:0007413)3.13906300
98regulation of exocytosis (GO:0017157)3.11881363
99positive regulation of dendrite development (GO:1900006)3.11227281
100positive regulation of synaptic transmission (GO:0050806)3.09495621
101cell communication by electrical coupling (GO:0010644)3.09483102
102neurotransmitter uptake (GO:0001504)3.09361268
103membrane hyperpolarization (GO:0060081)3.09106731
104establishment of synaptic vesicle localization (GO:0097480)3.08418569
105synaptic vesicle transport (GO:0048489)3.08418569
106cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08096760
107vesicle transport along microtubule (GO:0047496)3.07789029
108* regulation of ARF protein signal transduction (GO:0032012)3.07083041
109social behavior (GO:0035176)3.04975731
110intraspecies interaction between organisms (GO:0051703)3.04975731
111signal release (GO:0023061)3.03598453
112adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.02865028
113neuromuscular process (GO:0050905)3.01542196
114regulation of synaptic transmission (GO:0050804)3.01481362
115chemosensory behavior (GO:0007635)2.95600459
116negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94803067
117membrane depolarization during action potential (GO:0086010)2.94796451
118regulation of voltage-gated calcium channel activity (GO:1901385)2.94173411
119visual learning (GO:0008542)2.93166893
120cerebellar Purkinje cell layer development (GO:0021680)2.92816759
121innervation (GO:0060384)2.91731136
122synapse assembly (GO:0007416)2.91234439
123fear response (GO:0042596)2.89376623
124cerebellar Purkinje cell differentiation (GO:0021702)2.89202512
125mechanosensory behavior (GO:0007638)2.88770561
126neuromuscular process controlling posture (GO:0050884)2.88223729

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.79662517
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.15656968
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09876141
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05586189
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01584062
6GBX2_23144817_ChIP-Seq_PC3_Human2.91169032
7REST_21632747_ChIP-Seq_MESCs_Mouse2.86418451
8DROSHA_22980978_ChIP-Seq_HELA_Human2.80538294
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78584036
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78584036
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72537601
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63568580
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60527470
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59217965
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.50923488
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46753329
17* EZH2_27304074_Chip-Seq_ESCs_Mouse2.46501820
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45911691
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40724544
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.37250364
21* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.36734651
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.35456261
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.32078807
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.27798674
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11608967
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.08652698
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03025516
28AR_21572438_ChIP-Seq_LNCaP_Human1.86933070
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85304828
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.77940739
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58165805
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55757264
33RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.46211419
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46151636
35* KDM2B_26808549_Chip-Seq_K562_Human1.45859285
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.43170029
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41438031
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38493119
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35792658
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35161393
41SMAD4_21799915_ChIP-Seq_A2780_Human1.34041474
42* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33944311
43WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28355977
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27958271
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27220879
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.23691520
47GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23011864
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22087734
49* RING1B_27294783_Chip-Seq_NPCs_Mouse1.21274242
50AR_19668381_ChIP-Seq_PC3_Human1.20681787
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19439861
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18270919
53ZNF274_21170338_ChIP-Seq_K562_Hela1.17286857
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15260037
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14722158
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14582607
57P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13858070
58OCT4_19829295_ChIP-Seq_ESCs_Human1.13456509
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09977257
60ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09692274
61RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09203563
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.07421188
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.07041098
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06490693
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06476561
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06148276
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.06060165
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04777541
69AR_25329375_ChIP-Seq_VCAP_Human1.04310132
70STAT3_23295773_ChIP-Seq_U87_Human1.02982057
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02464989
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02362161
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01215336
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.01129575
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00149477
76CTCF_27219007_Chip-Seq_Bcells_Human1.00057928
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98756362
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98649537
79YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98315978
80PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97252457
81DPY_21335234_ChIP-Seq_ESCs_Mouse0.97225465
82TET1_21490601_ChIP-Seq_MESCs_Mouse0.97173889
83* P68_20966046_ChIP-Seq_HELA_Human0.97031929
84TAF15_26573619_Chip-Seq_HEK293_Human0.96934878
85* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95021008
86SMAD3_21741376_ChIP-Seq_HESCs_Human0.94860295
87P300_19829295_ChIP-Seq_ESCs_Human0.94340984
88CREB1_26743006_Chip-Seq_LNCaP_Human0.93490739
89SMAD3_21741376_ChIP-Seq_ESCs_Human0.92988033
90SMAD4_21741376_ChIP-Seq_HESCs_Human0.92795440
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92788011
92KDM2B_26808549_Chip-Seq_DND41_Human0.92478600
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92227204
94ARNT_22903824_ChIP-Seq_MCF-7_Human0.92043640
95TCF4_23295773_ChIP-Seq_U87_Human0.90976313
96TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90543811
97AHR_22903824_ChIP-Seq_MCF-7_Human0.89992890
98CBX2_27304074_Chip-Seq_ESCs_Mouse0.88904422
99* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88494745
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87716329
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86892077
102GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86275548
103TP53_20018659_ChIP-ChIP_R1E_Mouse0.85727336
104RXR_22108803_ChIP-Seq_LS180_Human0.85323377
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85217492
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84043204
107ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83826292
108PRDM14_20953172_ChIP-Seq_ESCs_Human0.83349700
109CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83013330
110NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82755330
111KLF4_19829295_ChIP-Seq_ESCs_Human0.82389861
112SMAD4_21741376_ChIP-Seq_ESCs_Human0.81733152
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81308038
114RNF2_27304074_Chip-Seq_NSC_Mouse0.80827355
115OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.80619530
116LXR_22292898_ChIP-Seq_THP-1_Human0.79905154
117TET1_21451524_ChIP-Seq_MESCs_Mouse0.79081908
118SMC4_20622854_ChIP-Seq_HELA_Human0.78035495
119RUNX2_22187159_ChIP-Seq_PCA_Human0.77895085
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77383777
121* KDM2B_26808549_Chip-Seq_JURKAT_Human0.77193096
122MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.76006960
123RUNX1_26923725_Chip-Seq_HPCs_Mouse0.75945467
124EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.75307691
125EGR1_19032775_ChIP-ChIP_M12_Human0.73381602
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.72990591
127MYC_19915707_ChIP-ChIP_AK7_Human0.72826858
128TP53_23651856_ChIP-Seq_MEFs_Mouse0.72438092
129SA1_27219007_Chip-Seq_Bcells_Human0.71812211
130CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.71764182

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.69270784
2MP0003635_abnormal_synaptic_transmissio4.44022163
3MP0003880_abnormal_central_pattern4.41004013
4MP0002822_catalepsy4.03706397
5MP0004270_analgesia3.98918812
6MP0002063_abnormal_learning/memory/cond3.65657877
7MP0009745_abnormal_behavioral_response3.55340479
8MP0002064_seizures3.15103404
9MP0005423_abnormal_somatic_nervous3.04929503
10MP0002572_abnormal_emotion/affect_behav2.84002808
11MP0009046_muscle_twitch2.78777310
12MP0001968_abnormal_touch/_nociception2.73779275
13MP0002734_abnormal_mechanical_nocicepti2.61893604
14MP0001486_abnormal_startle_reflex2.61125383
15MP0002272_abnormal_nervous_system2.42898408
16MP0009780_abnormal_chondrocyte_physiolo2.32502277
17MP0001501_abnormal_sleep_pattern2.16870302
18MP0002909_abnormal_adrenal_gland2.01488568
19MP0001440_abnormal_grooming_behavior1.99420485
20MP0004811_abnormal_neuron_physiology1.97771070
21MP0002733_abnormal_thermal_nociception1.96922016
22MP0004858_abnormal_nervous_system1.95610297
23MP0002735_abnormal_chemical_nociception1.94994337
24MP0002736_abnormal_nociception_after1.93824838
25MP0008569_lethality_at_weaning1.93341301
26MP0001970_abnormal_pain_threshold1.92189166
27MP0003329_amyloid_beta_deposits1.85608012
28MP0000778_abnormal_nervous_system1.81351300
29MP0002557_abnormal_social/conspecific_i1.79327236
30MP0003879_abnormal_hair_cell1.71660447
31MP0004924_abnormal_behavior1.70595660
32MP0005386_behavior/neurological_phenoty1.70595660
33MP0002184_abnormal_innervation1.69031246
34MP0002067_abnormal_sensory_capabilities1.68101847
35MP0005646_abnormal_pituitary_gland1.60108979
36MP0004885_abnormal_endolymph1.59233810
37MP0000955_abnormal_spinal_cord1.56392029
38MP0001984_abnormal_olfaction1.47197094
39MP0002882_abnormal_neuron_morphology1.42466156
40MP0002066_abnormal_motor_capabilities/c1.40770039
41MP0003633_abnormal_nervous_system1.39067892
42MP0003787_abnormal_imprinting1.36431995
43MP0003075_altered_response_to1.31813831
44MP0005645_abnormal_hypothalamus_physiol1.27040254
45MP0000569_abnormal_digit_pigmentation1.24837143
46MP0003123_paternal_imprinting1.23152172
47MP0001502_abnormal_circadian_rhythm1.18868078
48MP0001529_abnormal_vocalization1.17447439
49MP0003631_nervous_system_phenotype1.13775739
50MP0002152_abnormal_brain_morphology1.12857167
51MP0008961_abnormal_basal_metabolism1.09715290
52MP0003283_abnormal_digestive_organ1.07715208
53MP0001905_abnormal_dopamine_level1.06678063
54MP0001177_atelectasis1.06605900
55MP0006276_abnormal_autonomic_nervous1.06012078
56MP0002069_abnormal_eating/drinking_beha1.00274493
57MP0008872_abnormal_physiological_respon0.99219088
58MP0008874_decreased_physiological_sensi0.98202465
59MP0002638_abnormal_pupillary_reflex0.94454507
60MP0005167_abnormal_blood-brain_barrier0.91103718
61MP0001346_abnormal_lacrimal_gland0.89944121
62MP0004510_myositis0.89092320
63MP0001986_abnormal_taste_sensitivity0.88204434
64MP0002229_neurodegeneration0.87990836
65MP0004142_abnormal_muscle_tone0.87726452
66MP0002090_abnormal_vision0.87480545
67MP0000604_amyloidosis0.87300754
68MP0010234_abnormal_vibrissa_follicle0.85582460
69MP0000751_myopathy0.85420002
70MP0005535_abnormal_body_temperature0.84855095
71MP0003122_maternal_imprinting0.84719419
72MP0003690_abnormal_glial_cell0.83657617
73MP0005551_abnormal_eye_electrophysiolog0.83317633
74MP0000013_abnormal_adipose_tissue0.83083743
75MP0003634_abnormal_glial_cell0.82288762
76MP0005394_taste/olfaction_phenotype0.81730123
77MP0005499_abnormal_olfactory_system0.81730123
78MP0004085_abnormal_heartbeat0.81525981
79MP0010386_abnormal_urinary_bladder0.79908052
80MP0000920_abnormal_myelination0.75589587
81MP0003632_abnormal_nervous_system0.74278444
82MP0001188_hyperpigmentation0.73456572
83MP0003172_abnormal_lysosome_physiology0.72932542
84MP0000631_abnormal_neuroendocrine_gland0.72242167
85MP0001485_abnormal_pinna_reflex0.71665970
86MP0004147_increased_porphyrin_level0.71362200
87MP0005409_darkened_coat_color0.67180389
88MP0003183_abnormal_peptide_metabolism0.66251122
89MP0004742_abnormal_vestibular_system0.66028034
90MP0001963_abnormal_hearing_physiology0.64051328
91MP0002752_abnormal_somatic_nervous0.63138498
92MP0003137_abnormal_impulse_conducting0.62619786
93MP0004145_abnormal_muscle_electrophysio0.59150501
94MP0003303_peritoneal_inflammation0.58487605
95MP0004130_abnormal_muscle_cell0.58271127
96MP0008877_abnormal_DNA_methylation0.58146230
97MP0001664_abnormal_digestion0.57773425
98MP0003861_abnormal_nervous_system0.55934653
99MP0005166_decreased_susceptibility_to0.53910900
100MP0005187_abnormal_penis_morphology0.52430052
101MP0005623_abnormal_meninges_morphology0.51781666
102MP0010769_abnormal_survival0.51309211
103MP0001348_abnormal_lacrimal_gland0.51099150
104MP0000026_abnormal_inner_ear0.50987879
105MP0010768_mortality/aging0.50943285
106MP0004233_abnormal_muscle_weight0.50684142
107MP0003956_abnormal_body_size0.49825274
108MP0001943_abnormal_respiration0.48572163
109MP0010770_preweaning_lethality0.47585683
110MP0002082_postnatal_lethality0.47585683
111MP0003121_genomic_imprinting0.47223356
112MP0002653_abnormal_ependyma_morphology0.46237439
113MP0002873_normal_phenotype0.44361626
114MP0002169_no_abnormal_phenotype0.42985417
115MP0003938_abnormal_ear_development0.42375678

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.02656286
2Focal motor seizures (HP:0011153)7.09803527
3Focal seizures (HP:0007359)5.53925334
4Visual hallucinations (HP:0002367)5.33431087
5Epileptic encephalopathy (HP:0200134)4.43694400
6Action tremor (HP:0002345)4.00170088
7Ankle clonus (HP:0011448)3.98349304
8Progressive cerebellar ataxia (HP:0002073)3.91185654
9Febrile seizures (HP:0002373)3.87921352
10Atonic seizures (HP:0010819)3.80567677
11Supranuclear gaze palsy (HP:0000605)3.77303251
12Papilledema (HP:0001085)3.73680072
13Poor eye contact (HP:0000817)3.73510580
14Impaired vibration sensation in the lower limbs (HP:0002166)3.72446248
15Absence seizures (HP:0002121)3.65609179
16Generalized tonic-clonic seizures (HP:0002069)3.60786548
17Mutism (HP:0002300)3.54995833
18Broad-based gait (HP:0002136)3.53029014
19Depression (HP:0000716)3.49336962
20Urinary bladder sphincter dysfunction (HP:0002839)3.34707009
21Abnormal social behavior (HP:0012433)3.34269020
22Impaired social interactions (HP:0000735)3.34269020
23Dialeptic seizures (HP:0011146)3.33436967
24Torticollis (HP:0000473)3.30785712
25Delusions (HP:0000746)3.29772289
26Tetraplegia (HP:0002445)3.29755783
27Cerebral hypomyelination (HP:0006808)3.26363580
28Anxiety (HP:0000739)3.18410295
29Abnormality of the lower motor neuron (HP:0002366)3.16408611
30Dysdiadochokinesis (HP:0002075)3.15743540
31Postural instability (HP:0002172)3.15173762
32Gaze-evoked nystagmus (HP:0000640)3.12035713
33Abnormal eating behavior (HP:0100738)3.04771302
34Focal dystonia (HP:0004373)3.03881985
35Dysmetria (HP:0001310)3.03186177
36Urinary urgency (HP:0000012)2.99812509
37Annular pancreas (HP:0001734)2.98844305
38Genetic anticipation (HP:0003743)2.84735566
39Amblyopia (HP:0000646)2.83935781
40Stereotypic behavior (HP:0000733)2.80755078
41Megalencephaly (HP:0001355)2.78831414
42Truncal ataxia (HP:0002078)2.78550874
43Impaired smooth pursuit (HP:0007772)2.74365298
44Spastic gait (HP:0002064)2.72769466
45Craniofacial dystonia (HP:0012179)2.72195317
46Intention tremor (HP:0002080)2.68250109
47Peripheral hypomyelination (HP:0007182)2.64347417
48Neurofibrillary tangles (HP:0002185)2.62343251
49Hemiparesis (HP:0001269)2.61264632
50Excessive salivation (HP:0003781)2.60435401
51Drooling (HP:0002307)2.60435401
52Bradykinesia (HP:0002067)2.58964249
53Ventricular fibrillation (HP:0001663)2.57681015
54Pointed chin (HP:0000307)2.56822322
55Cerebral inclusion bodies (HP:0100314)2.53975375
56Obstructive sleep apnea (HP:0002870)2.53322087
57Hyperventilation (HP:0002883)2.49471910
58Progressive inability to walk (HP:0002505)2.49279649
59Diplopia (HP:0000651)2.49234671
60Abnormality of binocular vision (HP:0011514)2.49234671
61Impaired vibratory sensation (HP:0002495)2.48659664
62Hemiplegia (HP:0002301)2.47629505
63Insomnia (HP:0100785)2.40624701
64Abnormality of ocular smooth pursuit (HP:0000617)2.38288680
65Amyotrophic lateral sclerosis (HP:0007354)2.36204050
66Scanning speech (HP:0002168)2.34754356
67Spastic tetraparesis (HP:0001285)2.34651346
68Bundle branch block (HP:0011710)2.31978201
69Limb dystonia (HP:0002451)2.31557278
70Lower limb muscle weakness (HP:0007340)2.30438068
71Epileptiform EEG discharges (HP:0011182)2.30410968
72Dysmetric saccades (HP:0000641)2.27502457
73EEG with generalized epileptiform discharges (HP:0011198)2.25888416
74Lower limb amyotrophy (HP:0007210)2.24163598
75Hypsarrhythmia (HP:0002521)2.21291162
76Resting tremor (HP:0002322)2.21038196
77Abnormality of the corticospinal tract (HP:0002492)2.20998210
78Ankyloglossia (HP:0010296)2.20302793
79Fetal akinesia sequence (HP:0001989)2.18635509
80Apathy (HP:0000741)2.17288802
81Choreoathetosis (HP:0001266)2.16619809
82Insidious onset (HP:0003587)2.16191260
83Termporal pattern (HP:0011008)2.16191260
84Clonus (HP:0002169)2.13526444
85Polyphagia (HP:0002591)2.13334213
86Increased circulating renin level (HP:0000848)2.08923262
87Inappropriate behavior (HP:0000719)2.07278579
88Status epilepticus (HP:0002133)2.02275270
89Abnormal EKG (HP:0003115)2.02177231
90Split foot (HP:0001839)2.01644070
91CNS hypomyelination (HP:0003429)2.01032044
92Absent speech (HP:0001344)1.99761938
93Agitation (HP:0000713)1.99347131
94Lower limb asymmetry (HP:0100559)1.98408495
95Generalized myoclonic seizures (HP:0002123)1.96931496
96Incomplete penetrance (HP:0003829)1.96116419
97Neuronal loss in central nervous system (HP:0002529)1.95457901
98Morphological abnormality of the pyramidal tract (HP:0002062)1.94584983
99Aplasia involving bones of the upper limbs (HP:0009823)1.92756593
100Aplasia of the phalanges of the hand (HP:0009802)1.92756593
101Aplasia involving bones of the extremities (HP:0009825)1.92756593
102Diminished motivation (HP:0000745)1.91396525
103Inability to walk (HP:0002540)1.89816421
104Dementia (HP:0000726)1.85819525
105Abnormality of the periventricular white matter (HP:0002518)1.84361493
106Gait ataxia (HP:0002066)1.83057560
107Bronchomalacia (HP:0002780)1.82551184
108Rigidity (HP:0002063)1.82112705
109Memory impairment (HP:0002354)1.81882291
110Sleep apnea (HP:0010535)1.80278649
111Intellectual disability, profound (HP:0002187)1.80024708
112Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79370450
113Degeneration of the lateral corticospinal tracts (HP:0002314)1.79370450
114Abnormality of saccadic eye movements (HP:0000570)1.78712250
115Akinesia (HP:0002304)1.78285769
116Rapidly progressive (HP:0003678)1.77794827
117Abnormality of salivation (HP:0100755)1.73163173
118Spinal canal stenosis (HP:0003416)1.72298165

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.11004976
2MAP3K94.17494952
3NTRK34.06106753
4MARK13.78234892
5DAPK23.04054609
6PRKD32.85792409
7MINK12.72442455
8MAP3K42.45635130
9KSR22.45082607
10PAK62.39408713
11CAMKK12.36529635
12NTRK22.13558518
13MAP2K71.93289079
14KSR11.79204337
15NTRK11.73324193
16CDK51.68330496
17DAPK11.65143137
18RIPK41.64736983
19SIK21.58687165
20PRPF4B1.50537174
21TAOK11.47759358
22MAP2K41.44419031
23TYRO31.36433352
24MAP3K21.35696542
25STK381.33818240
26MAP3K131.33066613
27ARAF1.30922772
28FES1.27461327
29MAPK131.20276852
30TNIK1.16355252
31CAMKK21.16071099
32PLK21.13713143
33PRKCG1.13224412
34MAP3K121.12668521
35GRK51.12570516
36PHKG21.12009882
37PHKG11.12009882
38UHMK11.07286292
39CAMK11.01566419
40PRKCH1.00804740
41ALK1.00340589
42STK111.00031281
43CDK190.98658066
44LATS20.97094423
45MAP3K110.93678469
46RAF10.93359853
47CDK180.92910057
48CDK150.92833964
49MARK20.90066079
50CDK140.86159734
51RET0.86015050
52CDK11A0.81139351
53PKN10.80483591
54SGK4940.80020902
55SGK2230.80020902
56PINK10.79834208
57CAMK2A0.78676984
58RIPK10.78040247
59CAMK2G0.77884398
60TESK10.75361875
61PDK10.74745190
62PAK30.70830352
63SGK30.70582517
64CASK0.70089241
65LMTK20.69143849
66SGK10.68360833
67PTK2B0.68331696
68PDPK10.67417133
69LIMK10.65791407
70SGK20.64728659
71PNCK0.64056361
72BRAF0.63870348
73BRSK10.63518604
74DYRK1A0.63500637
75MAP3K10.63111775
76CAMK2B0.62067476
77PRKCZ0.61694140
78CSNK1G20.59413615
79BMPR20.57149497
80NEK10.55724981
81CAMK40.53175780
82FYN0.52178783
83RPS6KA30.50922711
84DAPK30.50872971
85MAP3K70.50189355
86CAMK1G0.49396906
87DMPK0.44971314
88SCYL20.44905940
89CDC42BPA0.44637711
90FGFR20.44625563
91PRKG20.44410906
92TNK20.43306052
93CCNB10.42978875
94WNK30.42723549
95RPS6KA20.42437655
96MAP2K10.40611247
97MAPK100.40441129
98NEK60.40229582
99CAMK2D0.38033526
100ERBB30.37900856
101ROCK20.37507497
102PRKCE0.34214609
103PRKCA0.33932162
104CAMK1D0.33523915
105ROCK10.32738462
106TRIB30.31123987
107PRKCB0.30212146
108DDR20.29373977
109PRKD20.29196017
110ERBB20.28731977
111IRAK20.28676269
112MAPK120.28542042
113OXSR10.27849147
114MAP2K60.27835507
115PDGFRA0.27214486
116MAPK80.26563579
117MAPK40.24452443
118GSK3B0.22840917
119SRC0.22304397

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.14261584
2Synaptic vesicle cycle_Homo sapiens_hsa047213.10645402
3Olfactory transduction_Homo sapiens_hsa047403.08179222
4Circadian entrainment_Homo sapiens_hsa047132.70493371
5Long-term potentiation_Homo sapiens_hsa047202.62909440
6GABAergic synapse_Homo sapiens_hsa047272.56977548
7Glutamatergic synapse_Homo sapiens_hsa047242.53448834
8Morphine addiction_Homo sapiens_hsa050322.47184823
9Amphetamine addiction_Homo sapiens_hsa050312.44172611
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42773287
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18008663
12Dopaminergic synapse_Homo sapiens_hsa047282.17828635
13Salivary secretion_Homo sapiens_hsa049702.08069330
14Cholinergic synapse_Homo sapiens_hsa047252.06986879
15Insulin secretion_Homo sapiens_hsa049111.99401932
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94922629
17Gastric acid secretion_Homo sapiens_hsa049711.91497797
18Vitamin B6 metabolism_Homo sapiens_hsa007501.80776198
19Cocaine addiction_Homo sapiens_hsa050301.77405459
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73412936
21Oxytocin signaling pathway_Homo sapiens_hsa049211.72036138
22Renin secretion_Homo sapiens_hsa049241.61828162
23Long-term depression_Homo sapiens_hsa047301.53176474
24Calcium signaling pathway_Homo sapiens_hsa040201.51811183
25GnRH signaling pathway_Homo sapiens_hsa049121.50957276
26Serotonergic synapse_Homo sapiens_hsa047261.43779925
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41655454
28Gap junction_Homo sapiens_hsa045401.40330903
29Taste transduction_Homo sapiens_hsa047421.40257100
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37870716
31Nitrogen metabolism_Homo sapiens_hsa009101.36078752
32Glioma_Homo sapiens_hsa052141.34131492
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32338554
34Type II diabetes mellitus_Homo sapiens_hsa049301.31310368
35cAMP signaling pathway_Homo sapiens_hsa040241.28396267
36Estrogen signaling pathway_Homo sapiens_hsa049151.19392837
37Axon guidance_Homo sapiens_hsa043601.15228956
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14529279
39ErbB signaling pathway_Homo sapiens_hsa040121.12235512
40Melanogenesis_Homo sapiens_hsa049161.06263660
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05410798
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04870675
43Phototransduction_Homo sapiens_hsa047441.00056632
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98223325
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96296556
46Phospholipase D signaling pathway_Homo sapiens_hsa040720.95635223
47Collecting duct acid secretion_Homo sapiens_hsa049660.93804166
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.92296751
49Oocyte meiosis_Homo sapiens_hsa041140.88710418
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86064119
51Dorso-ventral axis formation_Homo sapiens_hsa043200.84184558
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.82316628
53VEGF signaling pathway_Homo sapiens_hsa043700.79631451
54Pancreatic secretion_Homo sapiens_hsa049720.78196812
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78126727
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77675402
57Choline metabolism in cancer_Homo sapiens_hsa052310.76643061
58Thyroid hormone synthesis_Homo sapiens_hsa049180.74005441
59MAPK signaling pathway_Homo sapiens_hsa040100.73782885
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73579504
61Dilated cardiomyopathy_Homo sapiens_hsa054140.71979107
62mTOR signaling pathway_Homo sapiens_hsa041500.69594311
63Endometrial cancer_Homo sapiens_hsa052130.67551503
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67039929
65Non-small cell lung cancer_Homo sapiens_hsa052230.66859129
66Cardiac muscle contraction_Homo sapiens_hsa042600.66499161
67Rap1 signaling pathway_Homo sapiens_hsa040150.65010454
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64034354
69Type I diabetes mellitus_Homo sapiens_hsa049400.63938365
70Vibrio cholerae infection_Homo sapiens_hsa051100.62636580
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.61731361
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61538335
73Ras signaling pathway_Homo sapiens_hsa040140.60838432
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58035872
75* Endocytosis_Homo sapiens_hsa041440.57791417
76Alcoholism_Homo sapiens_hsa050340.57587631
77Glucagon signaling pathway_Homo sapiens_hsa049220.56766334
78Chemokine signaling pathway_Homo sapiens_hsa040620.55342311
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55076912
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54553194
81Renal cell carcinoma_Homo sapiens_hsa052110.51776876
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51741471
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49124874
84Bile secretion_Homo sapiens_hsa049760.49020481
85Prion diseases_Homo sapiens_hsa050200.48630171
86Insulin signaling pathway_Homo sapiens_hsa049100.45890246
87Inositol phosphate metabolism_Homo sapiens_hsa005620.45197278
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43320259
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42760477
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42393273
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42091821
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40113425
93Wnt signaling pathway_Homo sapiens_hsa043100.39596781
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36452416
95Arginine and proline metabolism_Homo sapiens_hsa003300.36408813
96Circadian rhythm_Homo sapiens_hsa047100.36383492
97Colorectal cancer_Homo sapiens_hsa052100.35904425
98African trypanosomiasis_Homo sapiens_hsa051430.35821846
99Prolactin signaling pathway_Homo sapiens_hsa049170.34729841
100Arginine biosynthesis_Homo sapiens_hsa002200.33286047
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32872457
102Ovarian steroidogenesis_Homo sapiens_hsa049130.32496737
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32200036
104Fatty acid biosynthesis_Homo sapiens_hsa000610.31581118
105Platelet activation_Homo sapiens_hsa046110.31253955
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31227543
107AMPK signaling pathway_Homo sapiens_hsa041520.23876490
108Mineral absorption_Homo sapiens_hsa049780.22694321
109Alzheimers disease_Homo sapiens_hsa050100.21110830
110Histidine metabolism_Homo sapiens_hsa003400.20894885
111Tight junction_Homo sapiens_hsa045300.19838091
112HIF-1 signaling pathway_Homo sapiens_hsa040660.19533808
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19467621

Most similar genes based on co-expression Upload to Enrichr

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