

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | locomotory exploration behavior (GO:0035641) | 5.95043756 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.73723096 |
| 3 | synaptic vesicle maturation (GO:0016188) | 5.29951126 |
| 4 | gamma-aminobutyric acid transport (GO:0015812) | 5.22901192 |
| 5 | cellular potassium ion homeostasis (GO:0030007) | 5.22085425 |
| 6 | vocalization behavior (GO:0071625) | 5.18250617 |
| 7 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.14364052 |
| 8 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.12735187 |
| 9 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.12326693 |
| 10 | sodium ion export (GO:0071436) | 5.02622797 |
| 11 | synaptic vesicle exocytosis (GO:0016079) | 4.88352114 |
| 12 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.83895865 |
| 13 | neuron cell-cell adhesion (GO:0007158) | 4.74210435 |
| 14 | layer formation in cerebral cortex (GO:0021819) | 4.65864990 |
| 15 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.63747852 |
| 16 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.59947413 |
| 17 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 4.56684367 |
| 18 | central nervous system myelination (GO:0022010) | 4.56116948 |
| 19 | axon ensheathment in central nervous system (GO:0032291) | 4.56116948 |
| 20 | cell communication by electrical coupling (GO:0010644) | 4.53966872 |
| 21 | neurotransmitter secretion (GO:0007269) | 4.53120067 |
| 22 | glutamate receptor signaling pathway (GO:0007215) | 4.51003481 |
| 23 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.48321711 |
| 24 | glutamate secretion (GO:0014047) | 4.48178283 |
| 25 | exploration behavior (GO:0035640) | 4.39080673 |
| 26 | protein localization to synapse (GO:0035418) | 4.38828393 |
| 27 | neuronal action potential propagation (GO:0019227) | 4.37055137 |
| 28 | cerebellar granule cell differentiation (GO:0021707) | 4.30137650 |
| 29 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 4.21680985 |
| 30 | cerebellar Purkinje cell differentiation (GO:0021702) | 4.16520161 |
| 31 | synaptic transmission, glutamatergic (GO:0035249) | 4.13948097 |
| 32 | response to pheromone (GO:0019236) | 4.10654490 |
| 33 | neuronal ion channel clustering (GO:0045161) | 4.09913435 |
| 34 | regulation of synaptic vesicle transport (GO:1902803) | 4.08743257 |
| 35 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.03117016 |
| 36 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 4.02204331 |
| 37 | long-term memory (GO:0007616) | 3.90905907 |
| 38 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.90549473 |
| 39 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.90469047 |
| 40 | postsynaptic membrane organization (GO:0001941) | 3.89061448 |
| 41 | proline transport (GO:0015824) | 3.85547044 |
| 42 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.82576763 |
| 43 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.82210541 |
| 44 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.81062177 |
| 45 | L-amino acid import (GO:0043092) | 3.80593439 |
| 46 | dendritic spine morphogenesis (GO:0060997) | 3.79282597 |
| 47 | neurotransmitter transport (GO:0006836) | 3.78296065 |
| 48 | dendrite morphogenesis (GO:0048813) | 3.78211332 |
| 49 | neuron-neuron synaptic transmission (GO:0007270) | 3.76838095 |
| 50 | potassium ion import (GO:0010107) | 3.76798355 |
| 51 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.72408370 |
| 52 | regulation of synapse structural plasticity (GO:0051823) | 3.70947937 |
| 53 | cerebellar Purkinje cell layer development (GO:0021680) | 3.68013372 |
| 54 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.66662205 |
| 55 | transmission of nerve impulse (GO:0019226) | 3.63165721 |
| 56 | establishment of mitochondrion localization (GO:0051654) | 3.63038264 |
| 57 | potassium ion homeostasis (GO:0055075) | 3.56625423 |
| 58 | cellular sodium ion homeostasis (GO:0006883) | 3.56050732 |
| 59 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.55987987 |
| 60 | regulation of neurotransmitter levels (GO:0001505) | 3.54035007 |
| 61 | cell differentiation in hindbrain (GO:0021533) | 3.51854116 |
| 62 | neuron recognition (GO:0008038) | 3.51244719 |
| 63 | glycine transport (GO:0015816) | 3.50898437 |
| 64 | amino acid import (GO:0043090) | 3.49534299 |
| 65 | response to auditory stimulus (GO:0010996) | 3.48687722 |
| 66 | regulation of synapse maturation (GO:0090128) | 3.47383845 |
| 67 | auditory behavior (GO:0031223) | 3.47008194 |
| 68 | synapse assembly (GO:0007416) | 3.45139450 |
| 69 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.44415370 |
| 70 | neuromuscular process controlling posture (GO:0050884) | 3.44037515 |
| 71 | positive regulation of membrane potential (GO:0045838) | 3.41085674 |
| 72 | mechanosensory behavior (GO:0007638) | 3.40348037 |
| 73 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.40004532 |
| 74 | neuromuscular process controlling balance (GO:0050885) | 3.39396682 |
| 75 | positive regulation of synapse maturation (GO:0090129) | 3.39112517 |
| 76 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.38179509 |
| 77 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.36472804 |
| 78 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 3.33386021 |
| 79 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.32887402 |
| 80 | presynaptic membrane assembly (GO:0097105) | 3.31489086 |
| 81 | axonal fasciculation (GO:0007413) | 3.31440638 |
| 82 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.30011870 |
| 83 | C4-dicarboxylate transport (GO:0015740) | 3.27155581 |
| 84 | regulation of neurotransmitter transport (GO:0051588) | 3.25411122 |
| 85 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.24770407 |
| 86 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.24031753 |
| 87 | regulation of postsynaptic membrane potential (GO:0060078) | 3.23746027 |
| 88 | regulation of respiratory system process (GO:0044065) | 3.23268639 |
| 89 | presynaptic membrane organization (GO:0097090) | 3.22144472 |
| 90 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.22045797 |
| 91 | synaptic vesicle endocytosis (GO:0048488) | 3.21395997 |
| 92 | positive regulation of synapse assembly (GO:0051965) | 3.19100936 |
| 93 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.16309097 |
| 94 | prepulse inhibition (GO:0060134) | 3.16083600 |
| 95 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.15941106 |
| 96 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 3.15052475 |
| 97 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.14415903 |
| 98 | regulation of neurotransmitter secretion (GO:0046928) | 3.11779337 |
| 99 | adult walking behavior (GO:0007628) | 3.09823316 |
| 100 | activation of protein kinase A activity (GO:0034199) | 3.09367269 |
| 101 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 3.08260889 |
| 102 | regulation of vesicle fusion (GO:0031338) | 3.05739944 |
| 103 | neuromuscular synaptic transmission (GO:0007274) | 3.05676517 |
| 104 | membrane depolarization during action potential (GO:0086010) | 3.05066842 |
| 105 | long-term synaptic potentiation (GO:0060291) | 3.04953907 |
| 106 | neurotransmitter uptake (GO:0001504) | 3.03612442 |
| 107 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 3.01365529 |
| 108 | mitochondrion transport along microtubule (GO:0047497) | 3.01365529 |
| 109 | acidic amino acid transport (GO:0015800) | 3.01185221 |
| 110 | L-glutamate transport (GO:0015813) | 3.00691963 |
| 111 | regulation of synaptic plasticity (GO:0048167) | 3.00195694 |
| 112 | alanine transport (GO:0032328) | 3.00028656 |
| 113 | positive regulation of dendritic spine development (GO:0060999) | 2.99272959 |
| 114 | synapse organization (GO:0050808) | 2.98988708 |
| 115 | membrane hyperpolarization (GO:0060081) | 2.98304857 |
| 116 | cell migration in hindbrain (GO:0021535) | 2.94167052 |
| 117 | membrane depolarization (GO:0051899) | 2.93955969 |
| 118 | regulation of respiratory gaseous exchange (GO:0043576) | 2.93246048 |
| 119 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.92719027 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.99150147 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.16256847 |
| 3 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.10174075 |
| 4 | * SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.04867847 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.99766235 |
| 6 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.73178139 |
| 7 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.73178139 |
| 8 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.70085365 |
| 9 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.61685756 |
| 10 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.61140612 |
| 11 | * DROSHA_22980978_ChIP-Seq_HELA_Human | 2.51729488 |
| 12 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.50969777 |
| 13 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.50948654 |
| 14 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.50522622 |
| 15 | * EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.48503891 |
| 16 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.45596290 |
| 17 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.36339005 |
| 18 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.33213957 |
| 19 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.25881382 |
| 20 | * RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.25194221 |
| 21 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.25044413 |
| 22 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.21360110 |
| 23 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.17548736 |
| 24 | * REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.14145388 |
| 25 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.13405511 |
| 26 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.11163611 |
| 27 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.01267471 |
| 28 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.92827417 |
| 29 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.89115305 |
| 30 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.84185738 |
| 31 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.72414831 |
| 32 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.59021842 |
| 33 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.55227763 |
| 34 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.54766817 |
| 35 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.54388245 |
| 36 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.52529168 |
| 37 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.51615175 |
| 38 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.47705229 |
| 39 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.46377699 |
| 40 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.44375111 |
| 41 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.39169254 |
| 42 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.37654308 |
| 43 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.35589271 |
| 44 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.35342645 |
| 45 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.30155671 |
| 46 | AR_25329375_ChIP-Seq_VCAP_Human | 1.28235744 |
| 47 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.27975459 |
| 48 | P300_19829295_ChIP-Seq_ESCs_Human | 1.27164248 |
| 49 | AR_19668381_ChIP-Seq_PC3_Human | 1.25280813 |
| 50 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.23997633 |
| 51 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.23941640 |
| 52 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.23317090 |
| 53 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.22572819 |
| 54 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.21490014 |
| 55 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.20876506 |
| 56 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.18714581 |
| 57 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.18094827 |
| 58 | STAT3_23295773_ChIP-Seq_U87_Human | 1.17105827 |
| 59 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.16696572 |
| 60 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.16561297 |
| 61 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.16228343 |
| 62 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.14143451 |
| 63 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.12211918 |
| 64 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.12025773 |
| 65 | * TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.10791855 |
| 66 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.10246247 |
| 67 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.07841149 |
| 68 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.07824942 |
| 69 | * RNF2_27304074_Chip-Seq_NSC_Mouse | 1.07811473 |
| 70 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.06553405 |
| 71 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.05934278 |
| 72 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.05471427 |
| 73 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.04792888 |
| 74 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.03902950 |
| 75 | TCF4_23295773_ChIP-Seq_U87_Human | 1.03896965 |
| 76 | RXR_22108803_ChIP-Seq_LS180_Human | 1.03865360 |
| 77 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.03411884 |
| 78 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.03411884 |
| 79 | TP53_16413492_ChIP-PET_HCT116_Human | 1.02589934 |
| 80 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.01734156 |
| 81 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.01504687 |
| 82 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.00964759 |
| 83 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.00679404 |
| 84 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.00442028 |
| 85 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.99918221 |
| 86 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.99405619 |
| 87 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.97856686 |
| 88 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.97204472 |
| 89 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.97071215 |
| 90 | * P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.96633769 |
| 91 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.96149671 |
| 92 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.96126088 |
| 93 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.93905578 |
| 94 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.93749339 |
| 95 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.93151066 |
| 96 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.92527954 |
| 97 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.91394894 |
| 98 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.91242656 |
| 99 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.91014481 |
| 100 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.88719678 |
| 101 | * UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.86225646 |
| 102 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.85904629 |
| 103 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.85403231 |
| 104 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.84129236 |
| 105 | * TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.83080949 |
| 106 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.82856247 |
| 107 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.82721032 |
| 108 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.82719637 |
| 109 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.82691824 |
| 110 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.82148429 |
| 111 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.79120073 |
| 112 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.78702743 |
| 113 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.77422635 |
| 114 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.75548132 |
| 115 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.75355282 |
| 116 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.75050267 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.46615704 |
| 2 | MP0003880_abnormal_central_pattern | 4.58022256 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.91674558 |
| 4 | MP0005423_abnormal_somatic_nervous | 3.65298944 |
| 5 | MP0009046_muscle_twitch | 3.62881926 |
| 6 | MP0004270_analgesia | 3.20277834 |
| 7 | MP0009745_abnormal_behavioral_response | 3.14805567 |
| 8 | MP0002064_seizures | 3.05249909 |
| 9 | MP0002063_abnormal_learning/memory/cond | 3.03708306 |
| 10 | MP0001968_abnormal_touch/_nociception | 2.81976270 |
| 11 | MP0002572_abnormal_emotion/affect_behav | 2.67236458 |
| 12 | MP0001486_abnormal_startle_reflex | 2.63814245 |
| 13 | MP0001440_abnormal_grooming_behavior | 2.61107927 |
| 14 | MP0002734_abnormal_mechanical_nocicepti | 2.60472586 |
| 15 | MP0009780_abnormal_chondrocyte_physiolo | 2.54850816 |
| 16 | MP0002272_abnormal_nervous_system | 2.53758181 |
| 17 | MP0008569_lethality_at_weaning | 2.39604310 |
| 18 | MP0005646_abnormal_pituitary_gland | 2.39272207 |
| 19 | MP0002736_abnormal_nociception_after | 2.25540496 |
| 20 | MP0004858_abnormal_nervous_system | 2.21768701 |
| 21 | MP0001501_abnormal_sleep_pattern | 2.17999099 |
| 22 | MP0002067_abnormal_sensory_capabilities | 2.13853501 |
| 23 | MP0004885_abnormal_endolymph | 2.03452107 |
| 24 | MP0003329_amyloid_beta_deposits | 1.99938796 |
| 25 | MP0000778_abnormal_nervous_system | 1.98946974 |
| 26 | MP0005645_abnormal_hypothalamus_physiol | 1.98139037 |
| 27 | MP0002733_abnormal_thermal_nociception | 1.97109414 |
| 28 | MP0002557_abnormal_social/conspecific_i | 1.93921561 |
| 29 | MP0002184_abnormal_innervation | 1.89616369 |
| 30 | MP0002735_abnormal_chemical_nociception | 1.88009628 |
| 31 | MP0004924_abnormal_behavior | 1.85246669 |
| 32 | MP0005386_behavior/neurological_phenoty | 1.85246669 |
| 33 | MP0006276_abnormal_autonomic_nervous | 1.85213281 |
| 34 | MP0001970_abnormal_pain_threshold | 1.81583639 |
| 35 | MP0003690_abnormal_glial_cell | 1.79774400 |
| 36 | MP0001502_abnormal_circadian_rhythm | 1.69837501 |
| 37 | MP0004142_abnormal_muscle_tone | 1.66408097 |
| 38 | MP0000955_abnormal_spinal_cord | 1.59472850 |
| 39 | MP0004811_abnormal_neuron_physiology | 1.54255641 |
| 40 | MP0002909_abnormal_adrenal_gland | 1.47956644 |
| 41 | MP0001984_abnormal_olfaction | 1.46538996 |
| 42 | MP0002882_abnormal_neuron_morphology | 1.45764615 |
| 43 | MP0002066_abnormal_motor_capabilities/c | 1.43536800 |
| 44 | MP0003123_paternal_imprinting | 1.42001248 |
| 45 | MP0003122_maternal_imprinting | 1.35831356 |
| 46 | MP0003633_abnormal_nervous_system | 1.33841807 |
| 47 | MP0003787_abnormal_imprinting | 1.33134744 |
| 48 | MP0002638_abnormal_pupillary_reflex | 1.28630761 |
| 49 | MP0002822_catalepsy | 1.28386824 |
| 50 | MP0002152_abnormal_brain_morphology | 1.25081229 |
| 51 | MP0001986_abnormal_taste_sensitivity | 1.24498410 |
| 52 | MP0003879_abnormal_hair_cell | 1.23614350 |
| 53 | MP0003631_nervous_system_phenotype | 1.19695275 |
| 54 | MP0004742_abnormal_vestibular_system | 1.17374565 |
| 55 | MP0004145_abnormal_muscle_electrophysio | 1.14614021 |
| 56 | MP0003634_abnormal_glial_cell | 1.13369135 |
| 57 | MP0003121_genomic_imprinting | 1.13165541 |
| 58 | MP0003632_abnormal_nervous_system | 1.09740750 |
| 59 | MP0000569_abnormal_digit_pigmentation | 1.09651176 |
| 60 | MP0005551_abnormal_eye_electrophysiolog | 1.05874590 |
| 61 | MP0000631_abnormal_neuroendocrine_gland | 1.05476024 |
| 62 | MP0003137_abnormal_impulse_conducting | 1.03719952 |
| 63 | MP0001905_abnormal_dopamine_level | 1.03577723 |
| 64 | MP0002229_neurodegeneration | 1.01181265 |
| 65 | MP0004215_abnormal_myocardial_fiber | 0.96487939 |
| 66 | MP0001529_abnormal_vocalization | 0.93597397 |
| 67 | MP0000751_myopathy | 0.93432300 |
| 68 | MP0000920_abnormal_myelination | 0.92536476 |
| 69 | MP0000566_synostosis | 0.91598054 |
| 70 | MP0010386_abnormal_urinary_bladder | 0.89039069 |
| 71 | MP0002069_abnormal_eating/drinking_beha | 0.87264774 |
| 72 | MP0001188_hyperpigmentation | 0.87106122 |
| 73 | MP0001963_abnormal_hearing_physiology | 0.86820370 |
| 74 | MP0008872_abnormal_physiological_respon | 0.86819330 |
| 75 | MP0000604_amyloidosis | 0.85824243 |
| 76 | MP0001299_abnormal_eye_distance/ | 0.85803298 |
| 77 | MP0002752_abnormal_somatic_nervous | 0.81904925 |
| 78 | MP0001485_abnormal_pinna_reflex | 0.81142604 |
| 79 | MP0006072_abnormal_retinal_apoptosis | 0.80688956 |
| 80 | MP0001177_atelectasis | 0.78429257 |
| 81 | MP0008877_abnormal_DNA_methylation | 0.77581979 |
| 82 | MP0002089_abnormal_postnatal_growth/wei | 0.77440421 |
| 83 | MP0005499_abnormal_olfactory_system | 0.76563576 |
| 84 | MP0005394_taste/olfaction_phenotype | 0.76563576 |
| 85 | MP0004085_abnormal_heartbeat | 0.76019676 |
| 86 | MP0005409_darkened_coat_color | 0.72081712 |
| 87 | MP0003183_abnormal_peptide_metabolism | 0.71266609 |
| 88 | MP0003861_abnormal_nervous_system | 0.70672021 |
| 89 | MP0002653_abnormal_ependyma_morphology | 0.68199743 |
| 90 | MP0003075_altered_response_to | 0.66705739 |
| 91 | MP0008961_abnormal_basal_metabolism | 0.66546221 |
| 92 | MP0004130_abnormal_muscle_cell | 0.65619735 |
| 93 | MP0005535_abnormal_body_temperature | 0.64315729 |
| 94 | MP0005253_abnormal_eye_physiology | 0.63739320 |
| 95 | MP0002090_abnormal_vision | 0.63545698 |
| 96 | MP0005167_abnormal_blood-brain_barrier | 0.62870272 |
| 97 | MP0004147_increased_porphyrin_level | 0.60604115 |
| 98 | MP0001943_abnormal_respiration | 0.60567792 |
| 99 | MP0000026_abnormal_inner_ear | 0.59962193 |
| 100 | MP0008874_decreased_physiological_sensi | 0.59933783 |
| 101 | MP0010769_abnormal_survival | 0.59567465 |
| 102 | MP0000579_abnormal_nail_morphology | 0.59269213 |
| 103 | MP0004233_abnormal_muscle_weight | 0.58662019 |
| 104 | MP0002082_postnatal_lethality | 0.56806059 |
| 105 | MP0010770_preweaning_lethality | 0.56806059 |
| 106 | MP0009384_cardiac_valve_regurgitation | 0.55478876 |
| 107 | MP0010768_mortality/aging | 0.55309775 |
| 108 | MP0003283_abnormal_digestive_organ | 0.52773686 |
| 109 | MP0003938_abnormal_ear_development | 0.52340149 |
| 110 | MP0003646_muscle_fatigue | 0.51791764 |
| 111 | MP0003956_abnormal_body_size | 0.50145576 |
| 112 | MP0005187_abnormal_penis_morphology | 0.48683001 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 6.10884664 |
| 2 | Myokymia (HP:0002411) | 5.51586018 |
| 3 | Focal seizures (HP:0007359) | 5.14364214 |
| 4 | Progressive cerebellar ataxia (HP:0002073) | 5.08749857 |
| 5 | Visual hallucinations (HP:0002367) | 4.90424271 |
| 6 | Action tremor (HP:0002345) | 4.88211001 |
| 7 | Aplasia involving bones of the upper limbs (HP:0009823) | 4.33650704 |
| 8 | Aplasia of the phalanges of the hand (HP:0009802) | 4.33650704 |
| 9 | Aplasia involving bones of the extremities (HP:0009825) | 4.33650704 |
| 10 | Epileptic encephalopathy (HP:0200134) | 4.30733668 |
| 11 | Atonic seizures (HP:0010819) | 3.96661106 |
| 12 | Febrile seizures (HP:0002373) | 3.90687253 |
| 13 | Supranuclear gaze palsy (HP:0000605) | 3.74833411 |
| 14 | Hemiparesis (HP:0001269) | 3.74028328 |
| 15 | Dysdiadochokinesis (HP:0002075) | 3.73420391 |
| 16 | Diplopia (HP:0000651) | 3.70649864 |
| 17 | Abnormality of binocular vision (HP:0011514) | 3.70649864 |
| 18 | Absence seizures (HP:0002121) | 3.58241455 |
| 19 | Generalized tonic-clonic seizures (HP:0002069) | 3.48370184 |
| 20 | Hemiplegia (HP:0002301) | 3.47203920 |
| 21 | Broad-based gait (HP:0002136) | 3.35560637 |
| 22 | Gaze-evoked nystagmus (HP:0000640) | 3.31193571 |
| 23 | Genetic anticipation (HP:0003743) | 3.29285902 |
| 24 | Dialeptic seizures (HP:0011146) | 3.26103484 |
| 25 | Abnormal eating behavior (HP:0100738) | 3.23428658 |
| 26 | Peripheral hypomyelination (HP:0007182) | 3.11323419 |
| 27 | Truncal ataxia (HP:0002078) | 3.07920408 |
| 28 | Mutism (HP:0002300) | 3.07071040 |
| 29 | Megalencephaly (HP:0001355) | 3.05623722 |
| 30 | Dysmetria (HP:0001310) | 3.00020666 |
| 31 | Ankle clonus (HP:0011448) | 2.99546052 |
| 32 | Depression (HP:0000716) | 2.98427955 |
| 33 | Scanning speech (HP:0002168) | 2.94993372 |
| 34 | Postural instability (HP:0002172) | 2.94820651 |
| 35 | Intention tremor (HP:0002080) | 2.91667813 |
| 36 | Akinesia (HP:0002304) | 2.89842495 |
| 37 | Neurofibrillary tangles (HP:0002185) | 2.86184259 |
| 38 | Impaired smooth pursuit (HP:0007772) | 2.84107707 |
| 39 | Poor eye contact (HP:0000817) | 2.83361396 |
| 40 | Anxiety (HP:0000739) | 2.76942865 |
| 41 | Obstructive sleep apnea (HP:0002870) | 2.75596402 |
| 42 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.70305005 |
| 43 | Narrow nasal bridge (HP:0000446) | 2.67490332 |
| 44 | Polyphagia (HP:0002591) | 2.67384959 |
| 45 | Abnormal social behavior (HP:0012433) | 2.62039577 |
| 46 | Impaired social interactions (HP:0000735) | 2.62039577 |
| 47 | Excessive salivation (HP:0003781) | 2.60161354 |
| 48 | Drooling (HP:0002307) | 2.60161354 |
| 49 | Status epilepticus (HP:0002133) | 2.59128285 |
| 50 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.57667359 |
| 51 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.57667359 |
| 52 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.56725097 |
| 53 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.54801012 |
| 54 | Progressive inability to walk (HP:0002505) | 2.49431747 |
| 55 | Abnormality of the corticospinal tract (HP:0002492) | 2.45204448 |
| 56 | Cerebral inclusion bodies (HP:0100314) | 2.45199641 |
| 57 | Dysmetric saccades (HP:0000641) | 2.42982314 |
| 58 | Cerebral hypomyelination (HP:0006808) | 2.38039439 |
| 59 | Spastic gait (HP:0002064) | 2.37753204 |
| 60 | Limb dystonia (HP:0002451) | 2.34355033 |
| 61 | Urinary urgency (HP:0000012) | 2.33216271 |
| 62 | Amyotrophic lateral sclerosis (HP:0007354) | 2.30793546 |
| 63 | Increased circulating renin level (HP:0000848) | 2.28870762 |
| 64 | Papilledema (HP:0001085) | 2.28513666 |
| 65 | Hyperventilation (HP:0002883) | 2.28037994 |
| 66 | Abnormality of the lower motor neuron (HP:0002366) | 2.25516987 |
| 67 | Bradykinesia (HP:0002067) | 2.24921727 |
| 68 | Pheochromocytoma (HP:0002666) | 2.24835973 |
| 69 | Agitation (HP:0000713) | 2.24491001 |
| 70 | Craniofacial dystonia (HP:0012179) | 2.24048467 |
| 71 | Tetraplegia (HP:0002445) | 2.23451410 |
| 72 | Apathy (HP:0000741) | 2.20133354 |
| 73 | Long nose (HP:0003189) | 2.17761216 |
| 74 | EEG with generalized epileptiform discharges (HP:0011198) | 2.14674926 |
| 75 | Stereotypic behavior (HP:0000733) | 2.14674142 |
| 76 | Annular pancreas (HP:0001734) | 2.13428706 |
| 77 | Delusions (HP:0000746) | 2.12766620 |
| 78 | Epileptiform EEG discharges (HP:0011182) | 2.11374441 |
| 79 | Lower limb muscle weakness (HP:0007340) | 2.10168050 |
| 80 | Ventricular fibrillation (HP:0001663) | 2.09890956 |
| 81 | Postural tremor (HP:0002174) | 2.09813539 |
| 82 | Hypsarrhythmia (HP:0002521) | 2.09650317 |
| 83 | Split foot (HP:0001839) | 2.09393255 |
| 84 | Insomnia (HP:0100785) | 2.08514934 |
| 85 | Fetal akinesia sequence (HP:0001989) | 2.01272908 |
| 86 | Amblyopia (HP:0000646) | 2.00825076 |
| 87 | Absent speech (HP:0001344) | 1.99898758 |
| 88 | Diminished motivation (HP:0000745) | 1.98461745 |
| 89 | Psychosis (HP:0000709) | 1.98115979 |
| 90 | Spastic tetraplegia (HP:0002510) | 1.96261540 |
| 91 | Spastic tetraparesis (HP:0001285) | 1.95343505 |
| 92 | Torticollis (HP:0000473) | 1.95061664 |
| 93 | Humeroradial synostosis (HP:0003041) | 1.94765238 |
| 94 | Synostosis involving the elbow (HP:0003938) | 1.94765238 |
| 95 | Abnormality of saccadic eye movements (HP:0000570) | 1.93042403 |
| 96 | Neuronal loss in central nervous system (HP:0002529) | 1.92002769 |
| 97 | Gait imbalance (HP:0002141) | 1.87891140 |
| 98 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.87863628 |
| 99 | Hypoplastic left heart (HP:0004383) | 1.87700644 |
| 100 | Gait ataxia (HP:0002066) | 1.87462828 |
| 101 | Hypoplasia of the corpus callosum (HP:0002079) | 1.84294404 |
| 102 | Morphological abnormality of the inner ear (HP:0011390) | 1.83631938 |
| 103 | Neuroendocrine neoplasm (HP:0100634) | 1.82427332 |
| 104 | Focal dystonia (HP:0004373) | 1.80906532 |
| 105 | Mixed hearing impairment (HP:0000410) | 1.80474843 |
| 106 | Specific learning disability (HP:0001328) | 1.80372144 |
| 107 | Aqueductal stenosis (HP:0002410) | 1.79771977 |
| 108 | Failure to thrive in infancy (HP:0001531) | 1.78521985 |
| 109 | Esotropia (HP:0000565) | 1.78354340 |
| 110 | CNS hypomyelination (HP:0003429) | 1.77300656 |
| 111 | Rigidity (HP:0002063) | 1.76355000 |
| 112 | Horizontal nystagmus (HP:0000666) | 1.74623662 |
| 113 | Abnormality of salivation (HP:0100755) | 1.72666695 |
| 114 | Limb ataxia (HP:0002070) | 1.70656993 |
| 115 | Blue irides (HP:0000635) | 1.70485810 |
| 116 | Impaired vibratory sensation (HP:0002495) | 1.70314968 |
| 117 | Incomplete penetrance (HP:0003829) | 1.68405186 |
| 118 | Pointed chin (HP:0000307) | 1.68035131 |
| 119 | Generalized myoclonic seizures (HP:0002123) | 1.65914618 |
| 120 | Clonus (HP:0002169) | 1.64553302 |
| 121 | Sleep apnea (HP:0010535) | 1.61945760 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 4.48136286 |
| 2 | NTRK3 | 3.77912011 |
| 3 | NTRK2 | 3.33691714 |
| 4 | MAP3K9 | 3.23337886 |
| 5 | MAP3K4 | 2.86648556 |
| 6 | MINK1 | 2.60587195 |
| 7 | EPHA4 | 2.58904678 |
| 8 | TNIK | 2.50673072 |
| 9 | MAP2K7 | 2.50405548 |
| 10 | PAK6 | 2.22069669 |
| 11 | MAPK13 | 2.05273646 |
| 12 | PHKG2 | 1.96199725 |
| 13 | PHKG1 | 1.96199725 |
| 14 | CAMKK1 | 1.81568108 |
| 15 | MAP2K4 | 1.75502831 |
| 16 | DAPK2 | 1.72648946 |
| 17 | CASK | 1.60634854 |
| 18 | MAP3K12 | 1.60433191 |
| 19 | SIK2 | 1.55928645 |
| 20 | CAMKK2 | 1.54496368 |
| 21 | TYRO3 | 1.49334907 |
| 22 | PRKCG | 1.49265813 |
| 23 | CDK5 | 1.45968177 |
| 24 | PNCK | 1.44242267 |
| 25 | PRKD3 | 1.41894725 |
| 26 | KSR1 | 1.39658053 |
| 27 | UHMK1 | 1.35725431 |
| 28 | STK38 | 1.35724369 |
| 29 | NTRK1 | 1.32451244 |
| 30 | KSR2 | 1.29666890 |
| 31 | PRPF4B | 1.29580140 |
| 32 | CDK19 | 1.23516016 |
| 33 | SGK223 | 1.21349139 |
| 34 | SGK494 | 1.21349139 |
| 35 | LMTK2 | 1.20183382 |
| 36 | NEK6 | 1.18986316 |
| 37 | SGK2 | 1.17492843 |
| 38 | DYRK1A | 1.14436021 |
| 39 | GRK5 | 1.10171696 |
| 40 | FGFR2 | 1.04930296 |
| 41 | MAPK12 | 1.02828302 |
| 42 | CDK15 | 1.02115117 |
| 43 | CDK18 | 1.01641392 |
| 44 | STK11 | 0.98952477 |
| 45 | SGK3 | 0.98761047 |
| 46 | WNK1 | 0.94246865 |
| 47 | PLK2 | 0.94180186 |
| 48 | CAMK1G | 0.93057150 |
| 49 | CAMK2A | 0.91783221 |
| 50 | CDK14 | 0.91672676 |
| 51 | RIPK1 | 0.90764706 |
| 52 | LATS2 | 0.89590568 |
| 53 | CDK11A | 0.89326522 |
| 54 | PRKCH | 0.89071598 |
| 55 | FES | 0.88839928 |
| 56 | PINK1 | 0.87296658 |
| 57 | PAK3 | 0.85853266 |
| 58 | RIPK4 | 0.79564532 |
| 59 | RET | 0.79520920 |
| 60 | CSNK1G2 | 0.79226489 |
| 61 | CAMK1 | 0.78095039 |
| 62 | ALK | 0.77366870 |
| 63 | ERBB3 | 0.74984898 |
| 64 | DAPK1 | 0.71180316 |
| 65 | CAMK2B | 0.71164874 |
| 66 | TNK2 | 0.70606531 |
| 67 | SGK1 | 0.67321481 |
| 68 | MAP3K2 | 0.67141046 |
| 69 | OXSR1 | 0.66335851 |
| 70 | CAMK2G | 0.65341263 |
| 71 | CDC42BPA | 0.61327275 |
| 72 | PRKCE | 0.57650744 |
| 73 | MARK2 | 0.57547834 |
| 74 | LIMK1 | 0.57309002 |
| 75 | RPS6KA3 | 0.55337864 |
| 76 | MUSK | 0.54962428 |
| 77 | CAMK4 | 0.52376333 |
| 78 | PRKCZ | 0.51723299 |
| 79 | CSNK1G3 | 0.51612608 |
| 80 | WNK3 | 0.51069942 |
| 81 | PKN1 | 0.50818975 |
| 82 | CSNK1A1L | 0.50085548 |
| 83 | FYN | 0.49685089 |
| 84 | BRSK1 | 0.49518364 |
| 85 | PDK1 | 0.46641635 |
| 86 | DYRK2 | 0.46302534 |
| 87 | TAOK1 | 0.46259609 |
| 88 | MAP3K13 | 0.46187604 |
| 89 | BCR | 0.45476639 |
| 90 | ROCK2 | 0.43999344 |
| 91 | MAPK10 | 0.43272732 |
| 92 | PDPK1 | 0.43242657 |
| 93 | CAMK2D | 0.43221501 |
| 94 | ADRBK1 | 0.42225991 |
| 95 | CSNK1D | 0.41669886 |
| 96 | PRKG1 | 0.41598439 |
| 97 | MAPKAPK5 | 0.39746250 |
| 98 | MAPK7 | 0.39729133 |
| 99 | FGR | 0.39191625 |
| 100 | PRKCA | 0.38459939 |
| 101 | ROCK1 | 0.38280769 |
| 102 | PRKCB | 0.37901392 |
| 103 | PRKACA | 0.37706479 |
| 104 | MAPK8 | 0.36246648 |
| 105 | CSNK1A1 | 0.36153261 |
| 106 | CSNK1E | 0.36016729 |
| 107 | MAPK4 | 0.35388715 |
| 108 | MAPK9 | 0.35243289 |
| 109 | RPS6KB1 | 0.34881181 |
| 110 | ERBB2 | 0.34647874 |
| 111 | ARAF | 0.34084756 |
| 112 | MAP3K11 | 0.32603176 |
| 113 | GSK3B | 0.32380727 |
| 114 | PRKDC | 0.31565125 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.00678295 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.88960138 |
| 3 | GABAergic synapse_Homo sapiens_hsa04727 | 2.84970524 |
| 4 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.73585884 |
| 5 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.70301753 |
| 6 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.59657083 |
| 7 | Circadian entrainment_Homo sapiens_hsa04713 | 2.52420986 |
| 8 | Morphine addiction_Homo sapiens_hsa05032 | 2.40063476 |
| 9 | Long-term potentiation_Homo sapiens_hsa04720 | 2.39570471 |
| 10 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.27765628 |
| 11 | Olfactory transduction_Homo sapiens_hsa04740 | 2.23850429 |
| 12 | Salivary secretion_Homo sapiens_hsa04970 | 2.19404099 |
| 13 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 2.16450703 |
| 14 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.01248213 |
| 15 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.98540596 |
| 16 | Long-term depression_Homo sapiens_hsa04730 | 1.92449163 |
| 17 | Insulin secretion_Homo sapiens_hsa04911 | 1.90303671 |
| 18 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.89018767 |
| 19 | Taste transduction_Homo sapiens_hsa04742 | 1.82556506 |
| 20 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.67072824 |
| 21 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.66130725 |
| 22 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.59796115 |
| 23 | Cocaine addiction_Homo sapiens_hsa05030 | 1.55209040 |
| 24 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.51087211 |
| 25 | Renin secretion_Homo sapiens_hsa04924 | 1.41846642 |
| 26 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.41833192 |
| 27 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.40998160 |
| 28 | Gap junction_Homo sapiens_hsa04540 | 1.40983580 |
| 29 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.38863359 |
| 30 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.38559321 |
| 31 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.25735007 |
| 32 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.22160548 |
| 33 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.16674203 |
| 34 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.15695756 |
| 35 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.13138309 |
| 36 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.10886259 |
| 37 | Axon guidance_Homo sapiens_hsa04360 | 1.09698655 |
| 38 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.05446424 |
| 39 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.03482683 |
| 40 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.03119308 |
| 41 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.02763251 |
| 42 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.00371229 |
| 43 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.98299681 |
| 44 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.97732498 |
| 45 | Melanogenesis_Homo sapiens_hsa04916 | 0.96462401 |
| 46 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.95722758 |
| 47 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.93246358 |
| 48 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.92203478 |
| 49 | Circadian rhythm_Homo sapiens_hsa04710 | 0.90907142 |
| 50 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.89069259 |
| 51 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.88704482 |
| 52 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.87381046 |
| 53 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.85650667 |
| 54 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.84718616 |
| 55 | Glioma_Homo sapiens_hsa05214 | 0.83945998 |
| 56 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.81879285 |
| 57 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.80667852 |
| 58 | Bile secretion_Homo sapiens_hsa04976 | 0.79760869 |
| 59 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.74231066 |
| 60 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.71787954 |
| 61 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.71555933 |
| 62 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.69617772 |
| 63 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.68674938 |
| 64 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.67515219 |
| 65 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.67480520 |
| 66 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.67047163 |
| 67 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.64374495 |
| 68 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.62716027 |
| 69 | Alzheimers disease_Homo sapiens_hsa05010 | 0.61580724 |
| 70 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.60925728 |
| 71 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.60833595 |
| 72 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.60730519 |
| 73 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.60047453 |
| 74 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.56338168 |
| 75 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.48739921 |
| 76 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.47424353 |
| 77 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.47192937 |
| 78 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.47146998 |
| 79 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.46961416 |
| 80 | Endometrial cancer_Homo sapiens_hsa05213 | 0.46151770 |
| 81 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.45717630 |
| 82 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.45635200 |
| 83 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.44761537 |
| 84 | Phototransduction_Homo sapiens_hsa04744 | 0.43944757 |
| 85 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.43729744 |
| 86 | Mineral absorption_Homo sapiens_hsa04978 | 0.42343983 |
| 87 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.42153830 |
| 88 | Alcoholism_Homo sapiens_hsa05034 | 0.40257034 |
| 89 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.39736233 |
| 90 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.39403313 |
| 91 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.38707673 |
| 92 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.38549670 |
| 93 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.34838145 |
| 94 | * Endocytosis_Homo sapiens_hsa04144 | 0.34747655 |
| 95 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.33985124 |
| 96 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.32600718 |
| 97 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.32565612 |
| 98 | Histidine metabolism_Homo sapiens_hsa00340 | 0.32424726 |
| 99 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.31956293 |
| 100 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.31214430 |
| 101 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.30790133 |
| 102 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.30541636 |
| 103 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.30038594 |
| 104 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.28637606 |
| 105 | Colorectal cancer_Homo sapiens_hsa05210 | 0.28628587 |
| 106 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.28410213 |
| 107 | Prion diseases_Homo sapiens_hsa05020 | 0.28257559 |
| 108 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.27328242 |
| 109 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.26572249 |
| 110 | Parkinsons disease_Homo sapiens_hsa05012 | 0.25083739 |
| 111 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.24049091 |
| 112 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.21387980 |

