PSD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.95043756
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.73723096
3synaptic vesicle maturation (GO:0016188)5.29951126
4gamma-aminobutyric acid transport (GO:0015812)5.22901192
5cellular potassium ion homeostasis (GO:0030007)5.22085425
6vocalization behavior (GO:0071625)5.18250617
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.14364052
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.12735187
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.12326693
10sodium ion export (GO:0071436)5.02622797
11synaptic vesicle exocytosis (GO:0016079)4.88352114
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.83895865
13neuron cell-cell adhesion (GO:0007158)4.74210435
14layer formation in cerebral cortex (GO:0021819)4.65864990
15regulation of synaptic vesicle exocytosis (GO:2000300)4.63747852
16regulation of glutamate receptor signaling pathway (GO:1900449)4.59947413
17regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.56684367
18central nervous system myelination (GO:0022010)4.56116948
19axon ensheathment in central nervous system (GO:0032291)4.56116948
20cell communication by electrical coupling (GO:0010644)4.53966872
21neurotransmitter secretion (GO:0007269)4.53120067
22glutamate receptor signaling pathway (GO:0007215)4.51003481
23neurotransmitter-gated ion channel clustering (GO:0072578)4.48321711
24glutamate secretion (GO:0014047)4.48178283
25exploration behavior (GO:0035640)4.39080673
26protein localization to synapse (GO:0035418)4.38828393
27neuronal action potential propagation (GO:0019227)4.37055137
28cerebellar granule cell differentiation (GO:0021707)4.30137650
29positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.21680985
30cerebellar Purkinje cell differentiation (GO:0021702)4.16520161
31synaptic transmission, glutamatergic (GO:0035249)4.13948097
32response to pheromone (GO:0019236)4.10654490
33neuronal ion channel clustering (GO:0045161)4.09913435
34regulation of synaptic vesicle transport (GO:1902803)4.08743257
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.03117016
36G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.02204331
37long-term memory (GO:0007616)3.90905907
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.90549473
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.90469047
40postsynaptic membrane organization (GO:0001941)3.89061448
41proline transport (GO:0015824)3.85547044
42regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.82576763
43synaptic vesicle docking involved in exocytosis (GO:0016081)3.82210541
44regulation of neuronal synaptic plasticity (GO:0048168)3.81062177
45L-amino acid import (GO:0043092)3.80593439
46dendritic spine morphogenesis (GO:0060997)3.79282597
47neurotransmitter transport (GO:0006836)3.78296065
48dendrite morphogenesis (GO:0048813)3.78211332
49neuron-neuron synaptic transmission (GO:0007270)3.76838095
50potassium ion import (GO:0010107)3.76798355
51regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.72408370
52regulation of synapse structural plasticity (GO:0051823)3.70947937
53cerebellar Purkinje cell layer development (GO:0021680)3.68013372
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.66662205
55transmission of nerve impulse (GO:0019226)3.63165721
56establishment of mitochondrion localization (GO:0051654)3.63038264
57potassium ion homeostasis (GO:0055075)3.56625423
58cellular sodium ion homeostasis (GO:0006883)3.56050732
59pyrimidine nucleobase catabolic process (GO:0006208)3.55987987
60regulation of neurotransmitter levels (GO:0001505)3.54035007
61cell differentiation in hindbrain (GO:0021533)3.51854116
62neuron recognition (GO:0008038)3.51244719
63glycine transport (GO:0015816)3.50898437
64amino acid import (GO:0043090)3.49534299
65response to auditory stimulus (GO:0010996)3.48687722
66regulation of synapse maturation (GO:0090128)3.47383845
67auditory behavior (GO:0031223)3.47008194
68synapse assembly (GO:0007416)3.45139450
69gamma-aminobutyric acid signaling pathway (GO:0007214)3.44415370
70neuromuscular process controlling posture (GO:0050884)3.44037515
71positive regulation of membrane potential (GO:0045838)3.41085674
72mechanosensory behavior (GO:0007638)3.40348037
73positive regulation of synaptic transmission, GABAergic (GO:0032230)3.40004532
74neuromuscular process controlling balance (GO:0050885)3.39396682
75positive regulation of synapse maturation (GO:0090129)3.39112517
76regulation of excitatory postsynaptic membrane potential (GO:0060079)3.38179509
77positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.36472804
78positive regulation of potassium ion transmembrane transport (GO:1901381)3.33386021
79positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.32887402
80presynaptic membrane assembly (GO:0097105)3.31489086
81axonal fasciculation (GO:0007413)3.31440638
82positive regulation of dendritic spine morphogenesis (GO:0061003)3.30011870
83C4-dicarboxylate transport (GO:0015740)3.27155581
84regulation of neurotransmitter transport (GO:0051588)3.25411122
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.24770407
86regulation of synaptic transmission, glutamatergic (GO:0051966)3.24031753
87regulation of postsynaptic membrane potential (GO:0060078)3.23746027
88regulation of respiratory system process (GO:0044065)3.23268639
89presynaptic membrane organization (GO:0097090)3.22144472
90regulation of voltage-gated calcium channel activity (GO:1901385)3.22045797
91synaptic vesicle endocytosis (GO:0048488)3.21395997
92positive regulation of synapse assembly (GO:0051965)3.19100936
93negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.16309097
94prepulse inhibition (GO:0060134)3.16083600
95adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.15941106
96negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.15052475
97regulation of dendritic spine morphogenesis (GO:0061001)3.14415903
98regulation of neurotransmitter secretion (GO:0046928)3.11779337
99adult walking behavior (GO:0007628)3.09823316
100activation of protein kinase A activity (GO:0034199)3.09367269
101regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.08260889
102regulation of vesicle fusion (GO:0031338)3.05739944
103neuromuscular synaptic transmission (GO:0007274)3.05676517
104membrane depolarization during action potential (GO:0086010)3.05066842
105long-term synaptic potentiation (GO:0060291)3.04953907
106neurotransmitter uptake (GO:0001504)3.03612442
107establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.01365529
108mitochondrion transport along microtubule (GO:0047497)3.01365529
109acidic amino acid transport (GO:0015800)3.01185221
110L-glutamate transport (GO:0015813)3.00691963
111regulation of synaptic plasticity (GO:0048167)3.00195694
112alanine transport (GO:0032328)3.00028656
113positive regulation of dendritic spine development (GO:0060999)2.99272959
114synapse organization (GO:0050808)2.98988708
115membrane hyperpolarization (GO:0060081)2.98304857
116cell migration in hindbrain (GO:0021535)2.94167052
117membrane depolarization (GO:0051899)2.93955969
118regulation of respiratory gaseous exchange (GO:0043576)2.93246048
119central nervous system projection neuron axonogenesis (GO:0021952)2.92719027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.99150147
2GBX2_23144817_ChIP-Seq_PC3_Human3.16256847
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10174075
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04867847
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99766235
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73178139
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73178139
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.70085365
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61685756
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61140612
11* DROSHA_22980978_ChIP-Seq_HELA_Human2.51729488
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50969777
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50948654
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50522622
15* EZH2_27304074_Chip-Seq_ESCs_Mouse2.48503891
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45596290
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.36339005
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.33213957
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.25881382
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.25194221
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25044413
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21360110
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.17548736
24* REST_18959480_ChIP-ChIP_MESCs_Mouse2.14145388
25AR_21572438_ChIP-Seq_LNCaP_Human2.13405511
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11163611
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01267471
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92827417
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89115305
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84185738
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72414831
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59021842
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.55227763
34ZNF274_21170338_ChIP-Seq_K562_Hela1.54766817
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54388245
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.52529168
37SMAD4_21799915_ChIP-Seq_A2780_Human1.51615175
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47705229
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46377699
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.44375111
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39169254
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37654308
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35589271
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.35342645
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30155671
46AR_25329375_ChIP-Seq_VCAP_Human1.28235744
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.27975459
48P300_19829295_ChIP-Seq_ESCs_Human1.27164248
49AR_19668381_ChIP-Seq_PC3_Human1.25280813
50* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23997633
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23941640
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23317090
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22572819
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21490014
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.20876506
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18714581
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.18094827
58STAT3_23295773_ChIP-Seq_U87_Human1.17105827
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16696572
60TAF15_26573619_Chip-Seq_HEK293_Human1.16561297
61OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16228343
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.14143451
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12211918
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.12025773
65* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10791855
66* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10246247
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07841149
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07824942
69* RNF2_27304074_Chip-Seq_NSC_Mouse1.07811473
70* KDM2B_26808549_Chip-Seq_K562_Human1.06553405
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05934278
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05471427
73YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04792888
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03902950
75TCF4_23295773_ChIP-Seq_U87_Human1.03896965
76RXR_22108803_ChIP-Seq_LS180_Human1.03865360
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03411884
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03411884
79TP53_16413492_ChIP-PET_HCT116_Human1.02589934
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01734156
81IGF1R_20145208_ChIP-Seq_DFB_Human1.01504687
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.00964759
83CTCF_27219007_Chip-Seq_Bcells_Human1.00679404
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00442028
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99918221
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99405619
87RUNX2_22187159_ChIP-Seq_PCA_Human0.97856686
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97204472
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97071215
90* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96633769
91SMAD4_21741376_ChIP-Seq_HESCs_Human0.96149671
92* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96126088
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.93905578
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93749339
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93151066
96RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92527954
97POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91394894
98AHR_22903824_ChIP-Seq_MCF-7_Human0.91242656
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91014481
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88719678
101* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86225646
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85904629
103BCAT_22108803_ChIP-Seq_LS180_Human0.85403231
104ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84129236
105* TP53_20018659_ChIP-ChIP_R1E_Mouse0.83080949
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82856247
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82721032
108ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82719637
109CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82691824
110TET1_21490601_ChIP-Seq_MESCs_Mouse0.82148429
111FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79120073
112SOX9_26525672_Chip-Seq_HEART_Mouse0.78702743
113KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.77422635
114* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.75548132
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75355282
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75050267

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.46615704
2MP0003880_abnormal_central_pattern4.58022256
3MP0003635_abnormal_synaptic_transmissio3.91674558
4MP0005423_abnormal_somatic_nervous3.65298944
5MP0009046_muscle_twitch3.62881926
6MP0004270_analgesia3.20277834
7MP0009745_abnormal_behavioral_response3.14805567
8MP0002064_seizures3.05249909
9MP0002063_abnormal_learning/memory/cond3.03708306
10MP0001968_abnormal_touch/_nociception2.81976270
11MP0002572_abnormal_emotion/affect_behav2.67236458
12MP0001486_abnormal_startle_reflex2.63814245
13MP0001440_abnormal_grooming_behavior2.61107927
14MP0002734_abnormal_mechanical_nocicepti2.60472586
15MP0009780_abnormal_chondrocyte_physiolo2.54850816
16MP0002272_abnormal_nervous_system2.53758181
17MP0008569_lethality_at_weaning2.39604310
18MP0005646_abnormal_pituitary_gland2.39272207
19MP0002736_abnormal_nociception_after2.25540496
20MP0004858_abnormal_nervous_system2.21768701
21MP0001501_abnormal_sleep_pattern2.17999099
22MP0002067_abnormal_sensory_capabilities2.13853501
23MP0004885_abnormal_endolymph2.03452107
24MP0003329_amyloid_beta_deposits1.99938796
25MP0000778_abnormal_nervous_system1.98946974
26MP0005645_abnormal_hypothalamus_physiol1.98139037
27MP0002733_abnormal_thermal_nociception1.97109414
28MP0002557_abnormal_social/conspecific_i1.93921561
29MP0002184_abnormal_innervation1.89616369
30MP0002735_abnormal_chemical_nociception1.88009628
31MP0004924_abnormal_behavior1.85246669
32MP0005386_behavior/neurological_phenoty1.85246669
33MP0006276_abnormal_autonomic_nervous1.85213281
34MP0001970_abnormal_pain_threshold1.81583639
35MP0003690_abnormal_glial_cell1.79774400
36MP0001502_abnormal_circadian_rhythm1.69837501
37MP0004142_abnormal_muscle_tone1.66408097
38MP0000955_abnormal_spinal_cord1.59472850
39MP0004811_abnormal_neuron_physiology1.54255641
40MP0002909_abnormal_adrenal_gland1.47956644
41MP0001984_abnormal_olfaction1.46538996
42MP0002882_abnormal_neuron_morphology1.45764615
43MP0002066_abnormal_motor_capabilities/c1.43536800
44MP0003123_paternal_imprinting1.42001248
45MP0003122_maternal_imprinting1.35831356
46MP0003633_abnormal_nervous_system1.33841807
47MP0003787_abnormal_imprinting1.33134744
48MP0002638_abnormal_pupillary_reflex1.28630761
49MP0002822_catalepsy1.28386824
50MP0002152_abnormal_brain_morphology1.25081229
51MP0001986_abnormal_taste_sensitivity1.24498410
52MP0003879_abnormal_hair_cell1.23614350
53MP0003631_nervous_system_phenotype1.19695275
54MP0004742_abnormal_vestibular_system1.17374565
55MP0004145_abnormal_muscle_electrophysio1.14614021
56MP0003634_abnormal_glial_cell1.13369135
57MP0003121_genomic_imprinting1.13165541
58MP0003632_abnormal_nervous_system1.09740750
59MP0000569_abnormal_digit_pigmentation1.09651176
60MP0005551_abnormal_eye_electrophysiolog1.05874590
61MP0000631_abnormal_neuroendocrine_gland1.05476024
62MP0003137_abnormal_impulse_conducting1.03719952
63MP0001905_abnormal_dopamine_level1.03577723
64MP0002229_neurodegeneration1.01181265
65MP0004215_abnormal_myocardial_fiber0.96487939
66MP0001529_abnormal_vocalization0.93597397
67MP0000751_myopathy0.93432300
68MP0000920_abnormal_myelination0.92536476
69MP0000566_synostosis0.91598054
70MP0010386_abnormal_urinary_bladder0.89039069
71MP0002069_abnormal_eating/drinking_beha0.87264774
72MP0001188_hyperpigmentation0.87106122
73MP0001963_abnormal_hearing_physiology0.86820370
74MP0008872_abnormal_physiological_respon0.86819330
75MP0000604_amyloidosis0.85824243
76MP0001299_abnormal_eye_distance/0.85803298
77MP0002752_abnormal_somatic_nervous0.81904925
78MP0001485_abnormal_pinna_reflex0.81142604
79MP0006072_abnormal_retinal_apoptosis0.80688956
80MP0001177_atelectasis0.78429257
81MP0008877_abnormal_DNA_methylation0.77581979
82MP0002089_abnormal_postnatal_growth/wei0.77440421
83MP0005499_abnormal_olfactory_system0.76563576
84MP0005394_taste/olfaction_phenotype0.76563576
85MP0004085_abnormal_heartbeat0.76019676
86MP0005409_darkened_coat_color0.72081712
87MP0003183_abnormal_peptide_metabolism0.71266609
88MP0003861_abnormal_nervous_system0.70672021
89MP0002653_abnormal_ependyma_morphology0.68199743
90MP0003075_altered_response_to0.66705739
91MP0008961_abnormal_basal_metabolism0.66546221
92MP0004130_abnormal_muscle_cell0.65619735
93MP0005535_abnormal_body_temperature0.64315729
94MP0005253_abnormal_eye_physiology0.63739320
95MP0002090_abnormal_vision0.63545698
96MP0005167_abnormal_blood-brain_barrier0.62870272
97MP0004147_increased_porphyrin_level0.60604115
98MP0001943_abnormal_respiration0.60567792
99MP0000026_abnormal_inner_ear0.59962193
100MP0008874_decreased_physiological_sensi0.59933783
101MP0010769_abnormal_survival0.59567465
102MP0000579_abnormal_nail_morphology0.59269213
103MP0004233_abnormal_muscle_weight0.58662019
104MP0002082_postnatal_lethality0.56806059
105MP0010770_preweaning_lethality0.56806059
106MP0009384_cardiac_valve_regurgitation0.55478876
107MP0010768_mortality/aging0.55309775
108MP0003283_abnormal_digestive_organ0.52773686
109MP0003938_abnormal_ear_development0.52340149
110MP0003646_muscle_fatigue0.51791764
111MP0003956_abnormal_body_size0.50145576
112MP0005187_abnormal_penis_morphology0.48683001

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.10884664
2Myokymia (HP:0002411)5.51586018
3Focal seizures (HP:0007359)5.14364214
4Progressive cerebellar ataxia (HP:0002073)5.08749857
5Visual hallucinations (HP:0002367)4.90424271
6Action tremor (HP:0002345)4.88211001
7Aplasia involving bones of the upper limbs (HP:0009823)4.33650704
8Aplasia of the phalanges of the hand (HP:0009802)4.33650704
9Aplasia involving bones of the extremities (HP:0009825)4.33650704
10Epileptic encephalopathy (HP:0200134)4.30733668
11Atonic seizures (HP:0010819)3.96661106
12Febrile seizures (HP:0002373)3.90687253
13Supranuclear gaze palsy (HP:0000605)3.74833411
14Hemiparesis (HP:0001269)3.74028328
15Dysdiadochokinesis (HP:0002075)3.73420391
16Diplopia (HP:0000651)3.70649864
17Abnormality of binocular vision (HP:0011514)3.70649864
18Absence seizures (HP:0002121)3.58241455
19Generalized tonic-clonic seizures (HP:0002069)3.48370184
20Hemiplegia (HP:0002301)3.47203920
21Broad-based gait (HP:0002136)3.35560637
22Gaze-evoked nystagmus (HP:0000640)3.31193571
23Genetic anticipation (HP:0003743)3.29285902
24Dialeptic seizures (HP:0011146)3.26103484
25Abnormal eating behavior (HP:0100738)3.23428658
26Peripheral hypomyelination (HP:0007182)3.11323419
27Truncal ataxia (HP:0002078)3.07920408
28Mutism (HP:0002300)3.07071040
29Megalencephaly (HP:0001355)3.05623722
30Dysmetria (HP:0001310)3.00020666
31Ankle clonus (HP:0011448)2.99546052
32Depression (HP:0000716)2.98427955
33Scanning speech (HP:0002168)2.94993372
34Postural instability (HP:0002172)2.94820651
35Intention tremor (HP:0002080)2.91667813
36Akinesia (HP:0002304)2.89842495
37Neurofibrillary tangles (HP:0002185)2.86184259
38Impaired smooth pursuit (HP:0007772)2.84107707
39Poor eye contact (HP:0000817)2.83361396
40Anxiety (HP:0000739)2.76942865
41Obstructive sleep apnea (HP:0002870)2.75596402
42Impaired vibration sensation in the lower limbs (HP:0002166)2.70305005
43Narrow nasal bridge (HP:0000446)2.67490332
44Polyphagia (HP:0002591)2.67384959
45Abnormal social behavior (HP:0012433)2.62039577
46Impaired social interactions (HP:0000735)2.62039577
47Excessive salivation (HP:0003781)2.60161354
48Drooling (HP:0002307)2.60161354
49Status epilepticus (HP:0002133)2.59128285
50Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.57667359
51Degeneration of the lateral corticospinal tracts (HP:0002314)2.57667359
52Abnormality of ocular smooth pursuit (HP:0000617)2.56725097
53Urinary bladder sphincter dysfunction (HP:0002839)2.54801012
54Progressive inability to walk (HP:0002505)2.49431747
55Abnormality of the corticospinal tract (HP:0002492)2.45204448
56Cerebral inclusion bodies (HP:0100314)2.45199641
57Dysmetric saccades (HP:0000641)2.42982314
58Cerebral hypomyelination (HP:0006808)2.38039439
59Spastic gait (HP:0002064)2.37753204
60Limb dystonia (HP:0002451)2.34355033
61Urinary urgency (HP:0000012)2.33216271
62Amyotrophic lateral sclerosis (HP:0007354)2.30793546
63Increased circulating renin level (HP:0000848)2.28870762
64Papilledema (HP:0001085)2.28513666
65Hyperventilation (HP:0002883)2.28037994
66Abnormality of the lower motor neuron (HP:0002366)2.25516987
67Bradykinesia (HP:0002067)2.24921727
68Pheochromocytoma (HP:0002666)2.24835973
69Agitation (HP:0000713)2.24491001
70Craniofacial dystonia (HP:0012179)2.24048467
71Tetraplegia (HP:0002445)2.23451410
72Apathy (HP:0000741)2.20133354
73Long nose (HP:0003189)2.17761216
74EEG with generalized epileptiform discharges (HP:0011198)2.14674926
75Stereotypic behavior (HP:0000733)2.14674142
76Annular pancreas (HP:0001734)2.13428706
77Delusions (HP:0000746)2.12766620
78Epileptiform EEG discharges (HP:0011182)2.11374441
79Lower limb muscle weakness (HP:0007340)2.10168050
80Ventricular fibrillation (HP:0001663)2.09890956
81Postural tremor (HP:0002174)2.09813539
82Hypsarrhythmia (HP:0002521)2.09650317
83Split foot (HP:0001839)2.09393255
84Insomnia (HP:0100785)2.08514934
85Fetal akinesia sequence (HP:0001989)2.01272908
86Amblyopia (HP:0000646)2.00825076
87Absent speech (HP:0001344)1.99898758
88Diminished motivation (HP:0000745)1.98461745
89Psychosis (HP:0000709)1.98115979
90Spastic tetraplegia (HP:0002510)1.96261540
91Spastic tetraparesis (HP:0001285)1.95343505
92Torticollis (HP:0000473)1.95061664
93Humeroradial synostosis (HP:0003041)1.94765238
94Synostosis involving the elbow (HP:0003938)1.94765238
95Abnormality of saccadic eye movements (HP:0000570)1.93042403
96Neuronal loss in central nervous system (HP:0002529)1.92002769
97Gait imbalance (HP:0002141)1.87891140
98Morphological abnormality of the pyramidal tract (HP:0002062)1.87863628
99Hypoplastic left heart (HP:0004383)1.87700644
100Gait ataxia (HP:0002066)1.87462828
101Hypoplasia of the corpus callosum (HP:0002079)1.84294404
102Morphological abnormality of the inner ear (HP:0011390)1.83631938
103Neuroendocrine neoplasm (HP:0100634)1.82427332
104Focal dystonia (HP:0004373)1.80906532
105Mixed hearing impairment (HP:0000410)1.80474843
106Specific learning disability (HP:0001328)1.80372144
107Aqueductal stenosis (HP:0002410)1.79771977
108Failure to thrive in infancy (HP:0001531)1.78521985
109Esotropia (HP:0000565)1.78354340
110CNS hypomyelination (HP:0003429)1.77300656
111Rigidity (HP:0002063)1.76355000
112Horizontal nystagmus (HP:0000666)1.74623662
113Abnormality of salivation (HP:0100755)1.72666695
114Limb ataxia (HP:0002070)1.70656993
115Blue irides (HP:0000635)1.70485810
116Impaired vibratory sensation (HP:0002495)1.70314968
117Incomplete penetrance (HP:0003829)1.68405186
118Pointed chin (HP:0000307)1.68035131
119Generalized myoclonic seizures (HP:0002123)1.65914618
120Clonus (HP:0002169)1.64553302
121Sleep apnea (HP:0010535)1.61945760

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.48136286
2NTRK33.77912011
3NTRK23.33691714
4MAP3K93.23337886
5MAP3K42.86648556
6MINK12.60587195
7EPHA42.58904678
8TNIK2.50673072
9MAP2K72.50405548
10PAK62.22069669
11MAPK132.05273646
12PHKG21.96199725
13PHKG11.96199725
14CAMKK11.81568108
15MAP2K41.75502831
16DAPK21.72648946
17CASK1.60634854
18MAP3K121.60433191
19SIK21.55928645
20CAMKK21.54496368
21TYRO31.49334907
22PRKCG1.49265813
23CDK51.45968177
24PNCK1.44242267
25PRKD31.41894725
26KSR11.39658053
27UHMK11.35725431
28STK381.35724369
29NTRK11.32451244
30KSR21.29666890
31PRPF4B1.29580140
32CDK191.23516016
33SGK2231.21349139
34SGK4941.21349139
35LMTK21.20183382
36NEK61.18986316
37SGK21.17492843
38DYRK1A1.14436021
39GRK51.10171696
40FGFR21.04930296
41MAPK121.02828302
42CDK151.02115117
43CDK181.01641392
44STK110.98952477
45SGK30.98761047
46WNK10.94246865
47PLK20.94180186
48CAMK1G0.93057150
49CAMK2A0.91783221
50CDK140.91672676
51RIPK10.90764706
52LATS20.89590568
53CDK11A0.89326522
54PRKCH0.89071598
55FES0.88839928
56PINK10.87296658
57PAK30.85853266
58RIPK40.79564532
59RET0.79520920
60CSNK1G20.79226489
61CAMK10.78095039
62ALK0.77366870
63ERBB30.74984898
64DAPK10.71180316
65CAMK2B0.71164874
66TNK20.70606531
67SGK10.67321481
68MAP3K20.67141046
69OXSR10.66335851
70CAMK2G0.65341263
71CDC42BPA0.61327275
72PRKCE0.57650744
73MARK20.57547834
74LIMK10.57309002
75RPS6KA30.55337864
76MUSK0.54962428
77CAMK40.52376333
78PRKCZ0.51723299
79CSNK1G30.51612608
80WNK30.51069942
81PKN10.50818975
82CSNK1A1L0.50085548
83FYN0.49685089
84BRSK10.49518364
85PDK10.46641635
86DYRK20.46302534
87TAOK10.46259609
88MAP3K130.46187604
89BCR0.45476639
90ROCK20.43999344
91MAPK100.43272732
92PDPK10.43242657
93CAMK2D0.43221501
94ADRBK10.42225991
95CSNK1D0.41669886
96PRKG10.41598439
97MAPKAPK50.39746250
98MAPK70.39729133
99FGR0.39191625
100PRKCA0.38459939
101ROCK10.38280769
102PRKCB0.37901392
103PRKACA0.37706479
104MAPK80.36246648
105CSNK1A10.36153261
106CSNK1E0.36016729
107MAPK40.35388715
108MAPK90.35243289
109RPS6KB10.34881181
110ERBB20.34647874
111ARAF0.34084756
112MAP3K110.32603176
113GSK3B0.32380727
114PRKDC0.31565125

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.00678295
2Synaptic vesicle cycle_Homo sapiens_hsa047212.88960138
3GABAergic synapse_Homo sapiens_hsa047272.84970524
4Glutamatergic synapse_Homo sapiens_hsa047242.73585884
5Nitrogen metabolism_Homo sapiens_hsa009102.70301753
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.59657083
7Circadian entrainment_Homo sapiens_hsa047132.52420986
8Morphine addiction_Homo sapiens_hsa050322.40063476
9Long-term potentiation_Homo sapiens_hsa047202.39570471
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.27765628
11Olfactory transduction_Homo sapiens_hsa047402.23850429
12Salivary secretion_Homo sapiens_hsa049702.19404099
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.16450703
14Amphetamine addiction_Homo sapiens_hsa050312.01248213
15Gastric acid secretion_Homo sapiens_hsa049711.98540596
16Long-term depression_Homo sapiens_hsa047301.92449163
17Insulin secretion_Homo sapiens_hsa049111.90303671
18Dopaminergic synapse_Homo sapiens_hsa047281.89018767
19Taste transduction_Homo sapiens_hsa047421.82556506
20Cholinergic synapse_Homo sapiens_hsa047251.67072824
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66130725
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59796115
23Cocaine addiction_Homo sapiens_hsa050301.55209040
24Serotonergic synapse_Homo sapiens_hsa047261.51087211
25Renin secretion_Homo sapiens_hsa049241.41846642
26Calcium signaling pathway_Homo sapiens_hsa040201.41833192
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40998160
28Gap junction_Homo sapiens_hsa045401.40983580
29Oxytocin signaling pathway_Homo sapiens_hsa049211.38863359
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38559321
31GnRH signaling pathway_Homo sapiens_hsa049121.25735007
32cAMP signaling pathway_Homo sapiens_hsa040241.22160548
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16674203
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15695756
35Type II diabetes mellitus_Homo sapiens_hsa049301.13138309
36Estrogen signaling pathway_Homo sapiens_hsa049151.10886259
37Axon guidance_Homo sapiens_hsa043601.09698655
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05446424
39Fatty acid biosynthesis_Homo sapiens_hsa000611.03482683
40Cardiac muscle contraction_Homo sapiens_hsa042601.03119308
41Dorso-ventral axis formation_Homo sapiens_hsa043201.02763251
42Vitamin B6 metabolism_Homo sapiens_hsa007501.00371229
43Pancreatic secretion_Homo sapiens_hsa049720.98299681
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97732498
45Melanogenesis_Homo sapiens_hsa049160.96462401
46ErbB signaling pathway_Homo sapiens_hsa040120.95722758
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.93246358
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92203478
49Circadian rhythm_Homo sapiens_hsa047100.90907142
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89069259
51Thyroid hormone synthesis_Homo sapiens_hsa049180.88704482
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87381046
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85650667
54Collecting duct acid secretion_Homo sapiens_hsa049660.84718616
55Glioma_Homo sapiens_hsa052140.83945998
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81879285
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80667852
58Bile secretion_Homo sapiens_hsa049760.79760869
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74231066
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71787954
61Choline metabolism in cancer_Homo sapiens_hsa052310.71555933
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.69617772
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68674938
64MAPK signaling pathway_Homo sapiens_hsa040100.67515219
65Oocyte meiosis_Homo sapiens_hsa041140.67480520
66Dilated cardiomyopathy_Homo sapiens_hsa054140.67047163
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64374495
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62716027
69Alzheimers disease_Homo sapiens_hsa050100.61580724
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.60925728
71Inositol phosphate metabolism_Homo sapiens_hsa005620.60833595
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60730519
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60047453
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.56338168
75Glucagon signaling pathway_Homo sapiens_hsa049220.48739921
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47424353
77Wnt signaling pathway_Homo sapiens_hsa043100.47192937
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47146998
79Vibrio cholerae infection_Homo sapiens_hsa051100.46961416
80Endometrial cancer_Homo sapiens_hsa052130.46151770
81Ras signaling pathway_Homo sapiens_hsa040140.45717630
82Rap1 signaling pathway_Homo sapiens_hsa040150.45635200
83Renal cell carcinoma_Homo sapiens_hsa052110.44761537
84Phototransduction_Homo sapiens_hsa047440.43944757
85mTOR signaling pathway_Homo sapiens_hsa041500.43729744
86Mineral absorption_Homo sapiens_hsa049780.42343983
87Type I diabetes mellitus_Homo sapiens_hsa049400.42153830
88Alcoholism_Homo sapiens_hsa050340.40257034
89beta-Alanine metabolism_Homo sapiens_hsa004100.39736233
90VEGF signaling pathway_Homo sapiens_hsa043700.39403313
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38707673
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38549670
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34838145
94* Endocytosis_Homo sapiens_hsa041440.34747655
95Insulin signaling pathway_Homo sapiens_hsa049100.33985124
96African trypanosomiasis_Homo sapiens_hsa051430.32600718
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32565612
98Histidine metabolism_Homo sapiens_hsa003400.32424726
99Hedgehog signaling pathway_Homo sapiens_hsa043400.31956293
100Arginine and proline metabolism_Homo sapiens_hsa003300.31214430
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30790133
102Regulation of autophagy_Homo sapiens_hsa041400.30541636
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.30038594
104Ovarian steroidogenesis_Homo sapiens_hsa049130.28637606
105Colorectal cancer_Homo sapiens_hsa052100.28628587
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28410213
107Prion diseases_Homo sapiens_hsa050200.28257559
108Chemokine signaling pathway_Homo sapiens_hsa040620.27328242
109Hippo signaling pathway_Homo sapiens_hsa043900.26572249
110Parkinsons disease_Homo sapiens_hsa050120.25083739
111AMPK signaling pathway_Homo sapiens_hsa041520.24049091
112Oxidative phosphorylation_Homo sapiens_hsa001900.21387980

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