PSD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.08607295
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.98226515
3locomotory exploration behavior (GO:0035641)5.96143403
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.79381937
5glutamate secretion (GO:0014047)5.43266413
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.36532912
7vocalization behavior (GO:0071625)5.32148476
8synaptic vesicle exocytosis (GO:0016079)5.26487235
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.16099448
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.07591060
11regulation of synaptic vesicle exocytosis (GO:2000300)4.95312674
12regulation of glutamate receptor signaling pathway (GO:1900449)4.81298946
13protein localization to synapse (GO:0035418)4.65005892
14exploration behavior (GO:0035640)4.61314345
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.58995502
16regulation of long-term neuronal synaptic plasticity (GO:0048169)4.47741415
17neuronal action potential propagation (GO:0019227)4.42527452
18regulation of neuronal synaptic plasticity (GO:0048168)4.39224336
19regulation of synaptic vesicle transport (GO:1902803)4.38634638
20neurotransmitter-gated ion channel clustering (GO:0072578)4.33422495
21layer formation in cerebral cortex (GO:0021819)4.30718281
22neurotransmitter secretion (GO:0007269)4.28363632
23neuron cell-cell adhesion (GO:0007158)4.26290114
24dendritic spine morphogenesis (GO:0060997)4.22969801
25synaptic transmission, glutamatergic (GO:0035249)4.22715599
26regulation of synapse structural plasticity (GO:0051823)4.21061607
27glutamate receptor signaling pathway (GO:0007215)4.12830111
28gamma-aminobutyric acid transport (GO:0015812)4.09688944
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.00907842
30neuron-neuron synaptic transmission (GO:0007270)3.94626514
31long-term memory (GO:0007616)3.94036079
32regulation of excitatory postsynaptic membrane potential (GO:0060079)3.84626344
33cellular sodium ion homeostasis (GO:0006883)3.83693724
34positive regulation of membrane potential (GO:0045838)3.82419034
35proline transport (GO:0015824)3.80804837
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.78309008
37amino acid import (GO:0043090)3.77136751
38cellular potassium ion homeostasis (GO:0030007)3.75174028
39potassium ion homeostasis (GO:0055075)3.69651306
40central nervous system myelination (GO:0022010)3.67881169
41axon ensheathment in central nervous system (GO:0032291)3.67881169
42regulation of dendritic spine morphogenesis (GO:0061001)3.66074298
43regulation of postsynaptic membrane potential (GO:0060078)3.62696029
44regulation of synaptic plasticity (GO:0048167)3.57736583
45activation of protein kinase A activity (GO:0034199)3.56424718
46positive regulation of synapse maturation (GO:0090129)3.53102250
47potassium ion import (GO:0010107)3.52997519
48dendrite morphogenesis (GO:0048813)3.49498450
49sodium ion export (GO:0071436)3.49329643
50neuromuscular process controlling balance (GO:0050885)3.48153911
51regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.47105322
52neurotransmitter transport (GO:0006836)3.43479913
53neuron recognition (GO:0008038)3.40651749
54long-term synaptic potentiation (GO:0060291)3.37716083
55positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.37429671
56regulation of neurotransmitter secretion (GO:0046928)3.35704206
57synaptic vesicle endocytosis (GO:0048488)3.34507255
58gamma-aminobutyric acid signaling pathway (GO:0007214)3.34434145
59auditory behavior (GO:0031223)3.34158676
60transmission of nerve impulse (GO:0019226)3.33406638
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.27605055
62cerebellar granule cell differentiation (GO:0021707)3.26562777
63cell communication involved in cardiac conduction (GO:0086065)3.25366254
64axonal fasciculation (GO:0007413)3.24364470
65cerebellar Purkinje cell differentiation (GO:0021702)3.24202859
66postsynaptic membrane organization (GO:0001941)3.23868825
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.22043488
68regulation of neurotransmitter levels (GO:0001505)3.20464788
69L-amino acid import (GO:0043092)3.20291992
70presynaptic membrane assembly (GO:0097105)3.18780682
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.18107363
72cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.16433997
73regulation of dendritic spine development (GO:0060998)3.16193074
74response to auditory stimulus (GO:0010996)3.12027192
75positive regulation of dendritic spine morphogenesis (GO:0061003)3.09790591
76regulation of neurotransmitter transport (GO:0051588)3.08937184
77positive regulation of neurotransmitter secretion (GO:0001956)3.08899819
78vesicle transport along microtubule (GO:0047496)3.08628810
79negative regulation of synaptic transmission, GABAergic (GO:0032229)3.07761459
80dendritic spine organization (GO:0097061)3.07690951
81membrane depolarization (GO:0051899)3.07353672
82negative regulation of dendrite morphogenesis (GO:0050774)3.07145625
83innervation (GO:0060384)3.07085753
84regulation of vesicle fusion (GO:0031338)3.05364704
85positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.03476319
86positive regulation of dendritic spine development (GO:0060999)3.01900855
87prepulse inhibition (GO:0060134)3.01765672
88regulation of synapse maturation (GO:0090128)3.01397069
89cell communication by electrical coupling (GO:0010644)2.99780790
90presynaptic membrane organization (GO:0097090)2.99095979
91neurotransmitter uptake (GO:0001504)2.99059913
92learning (GO:0007612)2.96289628
93G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.96142256
94membrane depolarization during action potential (GO:0086010)2.95377814
95positive regulation of synaptic transmission, GABAergic (GO:0032230)2.94879429
96synapse assembly (GO:0007416)2.92750236
97positive regulation of neurotransmitter transport (GO:0051590)2.91507452
98behavioral defense response (GO:0002209)2.91472469
99behavioral fear response (GO:0001662)2.91472469
100detection of calcium ion (GO:0005513)2.90719487
101membrane hyperpolarization (GO:0060081)2.90200954
102regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.89659848
103glycine transport (GO:0015816)2.89652601
104regulation of synaptic transmission (GO:0050804)2.89470619
105positive regulation of synaptic transmission (GO:0050806)2.89331402
106response to histamine (GO:0034776)2.89078138
107regulation of voltage-gated calcium channel activity (GO:1901385)2.88285139
108neuronal ion channel clustering (GO:0045161)2.88266297
109neuromuscular process (GO:0050905)2.87071089
110regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.86997268
111intraspecies interaction between organisms (GO:0051703)2.86961110
112social behavior (GO:0035176)2.86961110
113long term synaptic depression (GO:0060292)2.85140836
114organelle transport along microtubule (GO:0072384)2.84722357
115acidic amino acid transport (GO:0015800)2.84678649
116regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.81969936
117cell differentiation in hindbrain (GO:0021533)2.80994152
118adult walking behavior (GO:0007628)2.80963787
119mechanosensory behavior (GO:0007638)2.79209577
120cytoskeletal anchoring at plasma membrane (GO:0007016)2.78414020
121neuromuscular synaptic transmission (GO:0007274)2.73314668
122negative regulation of cytosolic calcium ion concentration (GO:0051481)2.71076251
123regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.64541939
124synaptic transmission (GO:0007268)2.64343055
125regulation of cell communication by electrical coupling (GO:0010649)2.64092245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.39026408
2GBX2_23144817_ChIP-Seq_PC3_Human3.44842535
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98266326
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95138842
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88019244
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61374102
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61374102
8DROSHA_22980978_ChIP-Seq_HELA_Human2.60105546
9REST_21632747_ChIP-Seq_MESCs_Mouse2.53626770
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.48851265
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48348415
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46168021
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44279120
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42712809
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39917051
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33323348
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.27907921
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.12406904
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.12181808
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11715456
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.09289315
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05062291
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.01981571
24AR_21572438_ChIP-Seq_LNCaP_Human1.99652745
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.92369181
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87009990
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82723952
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75085154
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71637286
30* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71170681
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66988837
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63233546
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.63180787
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53141695
35TAF15_26573619_Chip-Seq_HEK293_Human1.49889499
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.48069644
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41894497
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38670678
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.36007467
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.35010058
41* SOX2_21211035_ChIP-Seq_LN229_Gbm1.34457495
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31168318
43* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30846272
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.30119987
45* P300_19829295_ChIP-Seq_ESCs_Human1.29185512
46* STAT3_23295773_ChIP-Seq_U87_Human1.27748585
47* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25954869
48ZNF274_21170338_ChIP-Seq_K562_Hela1.25455104
49AR_25329375_ChIP-Seq_VCAP_Human1.25105228
50* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23516492
51RING1B_27294783_Chip-Seq_ESCs_Mouse1.23508936
52* AR_19668381_ChIP-Seq_PC3_Human1.22964699
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22670196
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.21792065
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20334803
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20279582
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20234850
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20000087
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17707289
60RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16875067
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16856697
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16749564
63* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16424972
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.15451798
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14982156
66TP53_16413492_ChIP-PET_HCT116_Human1.13725636
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13504401
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12525960
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11627738
70SOX9_26525672_Chip-Seq_HEART_Mouse1.11212223
71* TCF4_23295773_ChIP-Seq_U87_Human1.11082232
72AHR_22903824_ChIP-Seq_MCF-7_Human1.10918220
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10304481
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10136749
75* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09616790
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09570305
77GATA1_26923725_Chip-Seq_HPCs_Mouse1.08781487
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07672593
79KDM2B_26808549_Chip-Seq_K562_Human1.07390640
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.07075131
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.06456396
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.06230036
83* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04273305
84* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04009254
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.01712282
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01070459
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00999682
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99568073
89* TP53_18474530_ChIP-ChIP_U2OS_Human0.99427259
90RXR_22108803_ChIP-Seq_LS180_Human0.98413267
91SMAD4_21741376_ChIP-Seq_HESCs_Human0.98325469
92STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97884257
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96979364
94IGF1R_20145208_ChIP-Seq_DFB_Human0.96954123
95* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96863114
96POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96518426
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96405235
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96121610
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.95924845
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.95882881
101NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95799378
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95799378
103* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95032193
104* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95032193
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94943485
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94630786
107* RUNX2_22187159_ChIP-Seq_PCA_Human0.94202444
108SMAD3_21741376_ChIP-Seq_ESCs_Human0.93962412
109TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92796936
110* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89424457
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88886209
112ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87900526
113* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87735213
114BCAT_22108803_ChIP-Seq_LS180_Human0.86334883
115RNF2_27304074_Chip-Seq_NSC_Mouse0.85372667
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84228928
117* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83451755
118* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83446913

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.15233463
2MP0003880_abnormal_central_pattern4.58530507
3MP0003635_abnormal_synaptic_transmissio4.31617754
4MP0004270_analgesia4.17636598
5MP0002063_abnormal_learning/memory/cond3.45803988
6MP0009745_abnormal_behavioral_response3.44821503
7MP0002064_seizures3.20145391
8MP0009046_muscle_twitch3.18068679
9MP0001968_abnormal_touch/_nociception2.92000592
10MP0002572_abnormal_emotion/affect_behav2.82713535
11MP0005423_abnormal_somatic_nervous2.73362726
12MP0002734_abnormal_mechanical_nocicepti2.71764804
13MP0002822_catalepsy2.69256938
14MP0001486_abnormal_startle_reflex2.64449166
15MP0002272_abnormal_nervous_system2.57026516
16MP0009780_abnormal_chondrocyte_physiolo2.37287805
17MP0001501_abnormal_sleep_pattern2.19259499
18MP0001440_abnormal_grooming_behavior2.15606590
19MP0002735_abnormal_chemical_nociception2.12419592
20MP0002736_abnormal_nociception_after2.10900903
21MP0003329_amyloid_beta_deposits2.04901878
22MP0008569_lethality_at_weaning2.03549076
23MP0002733_abnormal_thermal_nociception1.93178362
24MP0002067_abnormal_sensory_capabilities1.93078912
25MP0000778_abnormal_nervous_system1.87518104
26MP0001970_abnormal_pain_threshold1.85858174
27MP0004811_abnormal_neuron_physiology1.80536148
28MP0004924_abnormal_behavior1.79919352
29MP0005386_behavior/neurological_phenoty1.79919352
30MP0004885_abnormal_endolymph1.74285155
31MP0004858_abnormal_nervous_system1.74013507
32MP0002557_abnormal_social/conspecific_i1.72423578
33MP0002184_abnormal_innervation1.70962028
34MP0002909_abnormal_adrenal_gland1.69005428
35MP0003879_abnormal_hair_cell1.58719986
36MP0000955_abnormal_spinal_cord1.58370828
37MP0005646_abnormal_pituitary_gland1.53531654
38MP0003633_abnormal_nervous_system1.51847497
39MP0000569_abnormal_digit_pigmentation1.49026566
40MP0002066_abnormal_motor_capabilities/c1.44637507
41MP0002882_abnormal_neuron_morphology1.40031265
42MP0001984_abnormal_olfaction1.35122802
43MP0003631_nervous_system_phenotype1.29104722
44MP0003787_abnormal_imprinting1.21099816
45MP0002653_abnormal_ependyma_morphology1.16767022
46MP0003690_abnormal_glial_cell1.16016731
47MP0001502_abnormal_circadian_rhythm1.13440255
48MP0006276_abnormal_autonomic_nervous1.12221380
49MP0002152_abnormal_brain_morphology1.10743947
50MP0000920_abnormal_myelination1.10275431
51MP0005645_abnormal_hypothalamus_physiol1.09570882
52MP0001905_abnormal_dopamine_level1.08049013
53MP0002638_abnormal_pupillary_reflex1.07040959
54MP0001177_atelectasis1.02790662
55MP0000604_amyloidosis1.02380895
56MP0004142_abnormal_muscle_tone1.01672731
57MP0004145_abnormal_muscle_electrophysio0.99938723
58MP0008872_abnormal_physiological_respon0.99462844
59MP0008874_decreased_physiological_sensi0.98580841
60MP0003075_altered_response_to0.97933485
61MP0003632_abnormal_nervous_system0.97593208
62MP0002229_neurodegeneration0.96794826
63MP0003123_paternal_imprinting0.96526670
64MP0001529_abnormal_vocalization0.92699591
65MP0002069_abnormal_eating/drinking_beha0.91168318
66MP0000751_myopathy0.90546235
67MP0004742_abnormal_vestibular_system0.89463305
68MP0003634_abnormal_glial_cell0.89342671
69MP0000566_synostosis0.86038631
70MP0001348_abnormal_lacrimal_gland0.84582256
71MP0005535_abnormal_body_temperature0.84070377
72MP0004085_abnormal_heartbeat0.82528936
73MP0005171_absent_coat_pigmentation0.80026446
74MP0008961_abnormal_basal_metabolism0.79266922
75MP0005551_abnormal_eye_electrophysiolog0.78205593
76MP0001188_hyperpigmentation0.78196118
77MP0004147_increased_porphyrin_level0.77938021
78MP0000013_abnormal_adipose_tissue0.77020885
79MP0001963_abnormal_hearing_physiology0.76076242
80MP0004510_myositis0.74281190
81MP0000026_abnormal_inner_ear0.73785399
82MP0002090_abnormal_vision0.73745415
83MP0005187_abnormal_penis_morphology0.71871248
84MP0005409_darkened_coat_color0.70953891
85MP0001299_abnormal_eye_distance/0.68397372
86MP0004215_abnormal_myocardial_fiber0.67706869
87MP0003122_maternal_imprinting0.67545022
88MP0010234_abnormal_vibrissa_follicle0.67484458
89MP0004484_altered_response_of0.66745326
90MP0004130_abnormal_muscle_cell0.66604631
91MP0005167_abnormal_blood-brain_barrier0.66583417
92MP0003283_abnormal_digestive_organ0.66154727
93MP0001346_abnormal_lacrimal_gland0.65585704
94MP0001485_abnormal_pinna_reflex0.64512261
95MP0003172_abnormal_lysosome_physiology0.64195916
96MP0010386_abnormal_urinary_bladder0.63896740
97MP0002234_abnormal_pharynx_morphology0.63358756
98MP0002752_abnormal_somatic_nervous0.63063230
99MP0000579_abnormal_nail_morphology0.62816300
100MP0000534_abnormal_ureter_morphology0.62049557
101MP0003137_abnormal_impulse_conducting0.62016013
102MP0000631_abnormal_neuroendocrine_gland0.61999155
103MP0002837_dystrophic_cardiac_calcinosis0.60955933
104MP0005623_abnormal_meninges_morphology0.60544014
105MP0003121_genomic_imprinting0.60529783
106MP0000639_abnormal_adrenal_gland0.60286288
107MP0010770_preweaning_lethality0.57786001
108MP0002082_postnatal_lethality0.57786001
109MP0001664_abnormal_digestion0.57266346
110MP0004043_abnormal_pH_regulation0.56410855
111MP0004233_abnormal_muscle_weight0.56277520
112MP0002249_abnormal_larynx_morphology0.55536621
113MP0010768_mortality/aging0.55228442
114MP0005394_taste/olfaction_phenotype0.54889505
115MP0005499_abnormal_olfactory_system0.54889505
116MP0010769_abnormal_survival0.52132490
117MP0003861_abnormal_nervous_system0.50927815
118MP0001943_abnormal_respiration0.50478121

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.40022169
2Myokymia (HP:0002411)6.91292128
3Focal seizures (HP:0007359)5.68649641
4Visual hallucinations (HP:0002367)5.02853239
5Epileptic encephalopathy (HP:0200134)4.79238651
6Progressive cerebellar ataxia (HP:0002073)4.41973606
7Action tremor (HP:0002345)4.37549210
8Atonic seizures (HP:0010819)4.21926588
9Febrile seizures (HP:0002373)4.01665877
10Absence seizures (HP:0002121)3.95642001
11Broad-based gait (HP:0002136)3.91672151
12Generalized tonic-clonic seizures (HP:0002069)3.78161061
13Supranuclear gaze palsy (HP:0000605)3.71577618
14Poor eye contact (HP:0000817)3.67615447
15Hyperventilation (HP:0002883)3.67281467
16Gaze-evoked nystagmus (HP:0000640)3.65692797
17Dialeptic seizures (HP:0011146)3.64426114
18Papilledema (HP:0001085)3.50474099
19Impaired vibration sensation in the lower limbs (HP:0002166)3.47738765
20Ankle clonus (HP:0011448)3.44725403
21Dysdiadochokinesis (HP:0002075)3.38038237
22Urinary bladder sphincter dysfunction (HP:0002839)3.34694413
23Dysmetria (HP:0001310)3.32915629
24Impaired social interactions (HP:0000735)3.31008081
25Abnormal social behavior (HP:0012433)3.31008081
26Mutism (HP:0002300)3.16230777
27Depression (HP:0000716)3.15981088
28Neurofibrillary tangles (HP:0002185)3.13018291
29Intention tremor (HP:0002080)3.07736195
30Postural instability (HP:0002172)3.06406333
31Truncal ataxia (HP:0002078)3.02925895
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.02791338
33Scanning speech (HP:0002168)3.02723457
34Cerebral inclusion bodies (HP:0100314)2.94898304
35Genetic anticipation (HP:0003743)2.92319104
36Excessive salivation (HP:0003781)2.91210158
37Drooling (HP:0002307)2.91210158
38Anxiety (HP:0000739)2.89303608
39Abnormal eating behavior (HP:0100738)2.86068175
40Urinary urgency (HP:0000012)2.82691732
41Abnormality of the corticospinal tract (HP:0002492)2.82244078
42Spastic gait (HP:0002064)2.81496373
43Impaired smooth pursuit (HP:0007772)2.80938859
44Torticollis (HP:0000473)2.79294888
45Abnormality of the lower motor neuron (HP:0002366)2.71086397
46Termporal pattern (HP:0011008)2.65938850
47Insidious onset (HP:0003587)2.65938850
48Dysmetric saccades (HP:0000641)2.65012433
49Diplopia (HP:0000651)2.61152262
50Abnormality of binocular vision (HP:0011514)2.61152262
51Megalencephaly (HP:0001355)2.61045269
52Stereotypic behavior (HP:0000733)2.60856285
53Amblyopia (HP:0000646)2.59929570
54Focal dystonia (HP:0004373)2.56045336
55Epileptiform EEG discharges (HP:0011182)2.55743540
56Hemiparesis (HP:0001269)2.53703019
57Hemiplegia (HP:0002301)2.50411999
58Abnormality of ocular smooth pursuit (HP:0000617)2.46590017
59EEG with generalized epileptiform discharges (HP:0011198)2.45545532
60Impaired vibratory sensation (HP:0002495)2.44801217
61Absent speech (HP:0001344)2.41545511
62Progressive inability to walk (HP:0002505)2.41111685
63Fetal akinesia sequence (HP:0001989)2.39676721
64Bradykinesia (HP:0002067)2.36708058
65Hypsarrhythmia (HP:0002521)2.35511675
66Status epilepticus (HP:0002133)2.31062544
67Lower limb muscle weakness (HP:0007340)2.29002431
68Craniofacial dystonia (HP:0012179)2.26594283
69Blue irides (HP:0000635)2.25768705
70Generalized myoclonic seizures (HP:0002123)2.25647849
71Tetraplegia (HP:0002445)2.20810799
72Obstructive sleep apnea (HP:0002870)2.17460475
73Pheochromocytoma (HP:0002666)2.15186910
74Sleep apnea (HP:0010535)2.11358093
75Ventricular fibrillation (HP:0001663)2.11325711
76Inappropriate behavior (HP:0000719)2.11042661
77Inability to walk (HP:0002540)2.11007711
78Amyotrophic lateral sclerosis (HP:0007354)2.10614550
79Annular pancreas (HP:0001734)2.06185474
80Agitation (HP:0000713)2.05641931
81Clonus (HP:0002169)2.01508804
82Gait ataxia (HP:0002066)2.00731560
83Abnormality of saccadic eye movements (HP:0000570)1.98999698
84Abnormality of salivation (HP:0100755)1.96180905
85Limb dystonia (HP:0002451)1.96083683
86Akinesia (HP:0002304)1.94690690
87Polyphagia (HP:0002591)1.91639874
88Abnormal ciliary motility (HP:0012262)1.90745468
89Bundle branch block (HP:0011710)1.89852950
90Lower limb amyotrophy (HP:0007210)1.89502672
91Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.88818302
92Degeneration of the lateral corticospinal tracts (HP:0002314)1.88818302
93Neuronal loss in central nervous system (HP:0002529)1.88106863
94Morphological abnormality of the pyramidal tract (HP:0002062)1.87888120
95Pointed chin (HP:0000307)1.87666989
96Incomplete penetrance (HP:0003829)1.87324041
97Aqueductal stenosis (HP:0002410)1.82941602
98Ankyloglossia (HP:0010296)1.82486568
99Abnormality of the periventricular white matter (HP:0002518)1.81676113
100Cutaneous finger syndactyly (HP:0010554)1.81429164
101Insomnia (HP:0100785)1.80175793
102Spastic tetraparesis (HP:0001285)1.79528378
103Rigidity (HP:0002063)1.77147939
104Cerebral hypomyelination (HP:0006808)1.76773049
105Aplasia involving bones of the upper limbs (HP:0009823)1.76474614
106Aplasia of the phalanges of the hand (HP:0009802)1.76474614
107Aplasia involving bones of the extremities (HP:0009825)1.76474614
108Turricephaly (HP:0000262)1.76302022
109Spastic tetraplegia (HP:0002510)1.75651178
110Abnormal respiratory motile cilium physiology (HP:0012261)1.75471111
111Gait imbalance (HP:0002141)1.72577683
112Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.72094532
113Apathy (HP:0000741)1.72070888
114Syncope (HP:0001279)1.71093986
115Bronchomalacia (HP:0002780)1.69278370
116Prolonged QT interval (HP:0001657)1.66649495
117Split foot (HP:0001839)1.65010604
118Hammertoe (HP:0001765)1.62014275
119Rhinitis (HP:0012384)1.61556978
120Atrial fibrillation (HP:0005110)1.56232297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.26826736
2NTRK34.08614301
3MAP3K93.88574944
4MARK13.72593924
5MAP3K42.89618802
6DAPK22.76930061
7MINK12.59282186
8PAK62.35085613
9MAP2K72.34212496
10KSR22.20154361
11PRKD32.09420769
12NTRK22.08359110
13CAMKK12.03585601
14NTRK11.93056284
15MAP2K41.88833178
16RIPK41.70076773
17KSR11.65873910
18CDK191.65605194
19CASK1.63421687
20CDK51.56664759
21DAPK11.49933978
22TNIK1.49575726
23PRPF4B1.46993569
24MAP3K121.40698995
25MAP3K21.40521445
26PLK21.35783590
27STK381.33466258
28CAMKK21.30868484
29MAPK131.24421795
30PHKG11.16506017
31PHKG21.16506017
32TYRO31.16485909
33PRKCG1.16167785
34GRK51.13645377
35SIK21.11436341
36OXSR11.07463637
37MAP3K131.07427177
38LATS21.05083225
39AKT31.03544408
40TAOK11.02059212
41STK111.00899004
42RET0.97964915
43FES0.96510734
44SGK2230.96203482
45SGK4940.96203482
46CAMK10.95875467
47CAMK2A0.94105083
48UHMK10.93095009
49PNCK0.91133477
50CDK180.90224282
51CDK150.89134191
52PRKCH0.86647563
53PAK30.86110544
54ARAF0.86089570
55CDK140.85093665
56SGK20.80225715
57SGK30.78309630
58PDK10.78050336
59CSNK1G20.78033080
60MET0.77840028
61CAMK2B0.77302692
62MARK20.77253543
63CDK11A0.75931151
64PDGFRA0.74998314
65PTK2B0.74919747
66SGK10.74800700
67RAF10.74491773
68PDPK10.73179217
69RIPK10.73103528
70BMPR20.70153252
71FGFR20.69455888
72ALK0.67868366
73ROCK20.65941463
74CAMK1G0.62999011
75LMTK20.62395079
76DYRK1A0.61480797
77PINK10.61003208
78LIMK10.59290789
79WNK10.57704569
80MAP3K70.57530229
81ROCK10.57463673
82MAP3K10.56718226
83PRKCZ0.55286624
84FYN0.53619745
85NEK60.53153034
86RPS6KA30.50760957
87CAMK40.48209968
88PKN10.48185485
89SCYL20.47609644
90PRKCE0.46815480
91BCR0.45626508
92CCNB10.45397289
93CSNK1A1L0.44395467
94CAMK2D0.44372623
95DMPK0.44124005
96ERBB20.43825134
97PDGFRB0.43183382
98BRSK10.42611117
99CAMK1D0.42204598
100STK390.41935190
101CAMK2G0.41584747
102MAPK100.40960777
103PTK20.40712457
104MAPK120.39450655
105CDC42BPA0.39432257
106MAP3K60.39144257
107PRKG10.38859338
108MOS0.37807669
109CSNK1D0.36218830
110MAP2K10.35892561
111MAPK150.33520318
112CSNK1G10.33467235
113FGR0.33450141
114FER0.32344887
115ERBB30.32260824
116DAPK30.32040315
117PRKACA0.31035086
118CSNK1E0.30613063
119DDR20.30070440
120CSNK1G30.29968919
121PRKCB0.29396671

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.44221401
2Synaptic vesicle cycle_Homo sapiens_hsa047212.93776076
3Circadian entrainment_Homo sapiens_hsa047132.68812400
4Long-term potentiation_Homo sapiens_hsa047202.67373596
5Olfactory transduction_Homo sapiens_hsa047402.62906553
6Glutamatergic synapse_Homo sapiens_hsa047242.60409790
7GABAergic synapse_Homo sapiens_hsa047272.55411442
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.54857847
9Morphine addiction_Homo sapiens_hsa050322.40971044
10Amphetamine addiction_Homo sapiens_hsa050312.36937021
11Salivary secretion_Homo sapiens_hsa049702.20348541
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08887438
13Dopaminergic synapse_Homo sapiens_hsa047282.05341445
14Insulin secretion_Homo sapiens_hsa049111.95472060
15Gastric acid secretion_Homo sapiens_hsa049711.91071392
16Cholinergic synapse_Homo sapiens_hsa047251.89057237
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.87169247
18Nitrogen metabolism_Homo sapiens_hsa009101.86099275
19Long-term depression_Homo sapiens_hsa047301.69110938
20Renin secretion_Homo sapiens_hsa049241.69086774
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63497173
22Oxytocin signaling pathway_Homo sapiens_hsa049211.62981916
23Taste transduction_Homo sapiens_hsa047421.56038159
24Calcium signaling pathway_Homo sapiens_hsa040201.50651343
25Cocaine addiction_Homo sapiens_hsa050301.50648698
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47524264
27Serotonergic synapse_Homo sapiens_hsa047261.47159080
28GnRH signaling pathway_Homo sapiens_hsa049121.43316670
29Gap junction_Homo sapiens_hsa045401.32622581
30Type II diabetes mellitus_Homo sapiens_hsa049301.31622094
31cAMP signaling pathway_Homo sapiens_hsa040241.28451873
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26829127
33Vitamin B6 metabolism_Homo sapiens_hsa007501.26611975
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25639294
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24137102
36Glioma_Homo sapiens_hsa052141.21022049
37Estrogen signaling pathway_Homo sapiens_hsa049151.19501074
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19088802
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17523454
40Axon guidance_Homo sapiens_hsa043601.16721732
41ErbB signaling pathway_Homo sapiens_hsa040121.09421027
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04463674
43Melanogenesis_Homo sapiens_hsa049161.01558651
44Dorso-ventral axis formation_Homo sapiens_hsa043200.99715968
45Collecting duct acid secretion_Homo sapiens_hsa049660.95544830
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.93015909
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.89898081
48Pancreatic secretion_Homo sapiens_hsa049720.88443468
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84970247
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80051941
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79708650
52Thyroid hormone synthesis_Homo sapiens_hsa049180.79187807
53Bile secretion_Homo sapiens_hsa049760.79143862
54Oocyte meiosis_Homo sapiens_hsa041140.76482482
55Choline metabolism in cancer_Homo sapiens_hsa052310.75946098
56Dilated cardiomyopathy_Homo sapiens_hsa054140.70748495
57Hippo signaling pathway_Homo sapiens_hsa043900.70396894
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69038251
59MAPK signaling pathway_Homo sapiens_hsa040100.67581885
60VEGF signaling pathway_Homo sapiens_hsa043700.63980131
61Cardiac muscle contraction_Homo sapiens_hsa042600.63844068
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.62664300
63Glucagon signaling pathway_Homo sapiens_hsa049220.61367027
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60494456
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59666774
66Ras signaling pathway_Homo sapiens_hsa040140.59635593
67mTOR signaling pathway_Homo sapiens_hsa041500.57473397
68Vibrio cholerae infection_Homo sapiens_hsa051100.57312017
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57159582
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.57117588
71Rap1 signaling pathway_Homo sapiens_hsa040150.55390469
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54943415
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54496819
74Hedgehog signaling pathway_Homo sapiens_hsa043400.54331976
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53361059
76Histidine metabolism_Homo sapiens_hsa003400.52302042
77Tight junction_Homo sapiens_hsa045300.51684226
78Inositol phosphate metabolism_Homo sapiens_hsa005620.51213022
79Arginine biosynthesis_Homo sapiens_hsa002200.51204777
80Renal cell carcinoma_Homo sapiens_hsa052110.50055040
81Endometrial cancer_Homo sapiens_hsa052130.49944030
82Phototransduction_Homo sapiens_hsa047440.49665185
83ECM-receptor interaction_Homo sapiens_hsa045120.47543848
84Non-small cell lung cancer_Homo sapiens_hsa052230.47307184
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47188729
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46950985
87Mineral absorption_Homo sapiens_hsa049780.46598771
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45677933
89Prion diseases_Homo sapiens_hsa050200.45619695
90Circadian rhythm_Homo sapiens_hsa047100.45486356
91* Endocytosis_Homo sapiens_hsa041440.45294303
92Ovarian steroidogenesis_Homo sapiens_hsa049130.43478562
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42741704
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42582425
95Insulin signaling pathway_Homo sapiens_hsa049100.42564847
96Arginine and proline metabolism_Homo sapiens_hsa003300.41791859
97Protein digestion and absorption_Homo sapiens_hsa049740.40015656
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39291136
99Wnt signaling pathway_Homo sapiens_hsa043100.39092376
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37361573
101Alcoholism_Homo sapiens_hsa050340.36824773
102African trypanosomiasis_Homo sapiens_hsa051430.36553375
103Fatty acid biosynthesis_Homo sapiens_hsa000610.35679113
104Adherens junction_Homo sapiens_hsa045200.35569568
105Chemokine signaling pathway_Homo sapiens_hsa040620.34587549
106Focal adhesion_Homo sapiens_hsa045100.34502750
107AMPK signaling pathway_Homo sapiens_hsa041520.32603362
108beta-Alanine metabolism_Homo sapiens_hsa004100.31902068
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31538971
110Butanoate metabolism_Homo sapiens_hsa006500.31513177
111Proteoglycans in cancer_Homo sapiens_hsa052050.30005053
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29546623
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29067834
114Platelet activation_Homo sapiens_hsa046110.27250328
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26751500
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25796004

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