PSENEN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.33401643
2cilium movement (GO:0003341)6.24826280
3epithelial cilium movement (GO:0003351)6.14137018
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.85973304
5central nervous system myelination (GO:0022010)5.59714751
6axon ensheathment in central nervous system (GO:0032291)5.59714751
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.57599008
8energy coupled proton transport, down electrochemical gradient (GO:0015985)5.46539604
9ATP synthesis coupled proton transport (GO:0015986)5.46539604
10establishment of protein localization to mitochondrial membrane (GO:0090151)5.36236247
11motile cilium assembly (GO:0044458)5.23523287
12respiratory electron transport chain (GO:0022904)5.03202155
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.99905606
14cilium or flagellum-dependent cell motility (GO:0001539)4.97661625
15left/right pattern formation (GO:0060972)4.91079857
16deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.91054023
17electron transport chain (GO:0022900)4.90341555
18oxidative phosphorylation (GO:0006119)4.72720969
19ribosomal small subunit assembly (GO:0000028)4.64752233
20signal peptide processing (GO:0006465)4.55606700
21ribosomal small subunit biogenesis (GO:0042274)4.51744434
22chaperone-mediated protein transport (GO:0072321)4.51128294
23fatty acid elongation (GO:0030497)4.44350125
24protein neddylation (GO:0045116)4.38737645
25sequestering of actin monomers (GO:0042989)4.27184234
26pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.26131075
27cotranslational protein targeting to membrane (GO:0006613)4.22816574
28respiratory chain complex IV assembly (GO:0008535)4.13971889
29protein targeting to ER (GO:0045047)4.13707709
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.12732598
31viral transcription (GO:0019083)4.10179133
32nucleoside triphosphate biosynthetic process (GO:0009142)4.09708143
33nucleoside diphosphate phosphorylation (GO:0006165)4.08677431
34protein complex biogenesis (GO:0070271)4.07937579
35protein localization to endoplasmic reticulum (GO:0070972)4.01183707
36guanosine-containing compound biosynthetic process (GO:1901070)3.96608633
37establishment of protein localization to endoplasmic reticulum (GO:0072599)3.93352006
38muscle organ morphogenesis (GO:0048644)3.90132688
39UTP metabolic process (GO:0046051)3.88541820
40translational termination (GO:0006415)3.87575647
41muscle cell fate commitment (GO:0042693)3.80202444
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.78417235
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.78417235
44NADH dehydrogenase complex assembly (GO:0010257)3.78417235
45axoneme assembly (GO:0035082)3.76211757
46GPI anchor biosynthetic process (GO:0006506)3.75309538
47negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.61874287
48cytochrome complex assembly (GO:0017004)3.59368332
49mitochondrial respiratory chain complex assembly (GO:0033108)3.55406481
50intraciliary transport (GO:0042073)3.50091109
51neutrophil activation involved in immune response (GO:0002283)3.48375139
52establishment of protein localization to mitochondrion (GO:0072655)3.47800012
53proteasome assembly (GO:0043248)3.39319515
54protein localization to mitochondrion (GO:0070585)3.39063354
55pyrimidine nucleotide catabolic process (GO:0006244)3.36414357
56negative regulation of ligase activity (GO:0051352)3.33825967
57negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.33825967
58pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.28463208
59regulation of cilium movement (GO:0003352)3.26924329
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26815855
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.26654550
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.26654550
63base-excision repair, AP site formation (GO:0006285)3.26189661
64pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.25294652
65positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.24997585
66GPI anchor metabolic process (GO:0006505)3.23986508
67L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.22768409
68pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.21072634
69regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19120207
70kinetochore assembly (GO:0051382)3.17725432
71hydrogen ion transmembrane transport (GO:1902600)3.15823956
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.15617795
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.15617795
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.15617795
75viral life cycle (GO:0019058)3.15069523
76signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.14246289
77intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.14246289
78purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.14150392
79purine nucleoside monophosphate biosynthetic process (GO:0009127)3.14150392
80outer ear morphogenesis (GO:0042473)3.13338154
81pentose metabolic process (GO:0019321)3.11014508
82GTP biosynthetic process (GO:0006183)3.10540484
83mitochondrial transport (GO:0006839)3.09171895
84* amyloid precursor protein metabolic process (GO:0042982)3.08770596
85signal transduction involved in DNA integrity checkpoint (GO:0072401)3.07644792
86signal transduction involved in DNA damage checkpoint (GO:0072422)3.07644792
87spliceosomal snRNP assembly (GO:0000387)3.06939383
88regulation of cardioblast proliferation (GO:0003264)3.06818296
89nucleotide transmembrane transport (GO:1901679)3.05858847
90translational elongation (GO:0006414)3.05295009
91mannosylation (GO:0097502)2.97834915
92proton transport (GO:0015992)2.96396188
93cellular protein complex disassembly (GO:0043624)2.93726850
94negative regulation of execution phase of apoptosis (GO:1900118)2.93539681
95positive regulation of cellular amine metabolic process (GO:0033240)2.90864995
96hydrogen transport (GO:0006818)2.89159931
97positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.85521907
98respiratory burst (GO:0045730)2.85380306
99autophagic vacuole fusion (GO:0000046)2.80299598
100long-chain fatty acid biosynthetic process (GO:0042759)2.80025662
101cholesterol biosynthetic process (GO:0006695)2.79630206
102protein targeting to membrane (GO:0006612)2.75240550
103preassembly of GPI anchor in ER membrane (GO:0016254)2.73977705
104antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.72771416
105translation (GO:0006412)2.71148685
106purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.69856196
107response to interferon-beta (GO:0035456)2.67782882
108purine nucleoside triphosphate biosynthetic process (GO:0009145)2.67216210
109termination of RNA polymerase III transcription (GO:0006386)2.66252454
110transcription elongation from RNA polymerase III promoter (GO:0006385)2.66252454
111antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.65660252
112DNA deamination (GO:0045006)2.60187895
113* amyloid precursor protein catabolic process (GO:0042987)2.59382447
114ATP biosynthetic process (GO:0006754)2.58232114
115substantia nigra development (GO:0021762)2.53660002
116C-terminal protein lipidation (GO:0006501)2.52191883
117sterol biosynthetic process (GO:0016126)2.51252107
118isoprenoid biosynthetic process (GO:0008299)2.49081020
119aerobic respiration (GO:0009060)2.48574430
120aldehyde catabolic process (GO:0046185)2.48149986
121regulation of metalloenzyme activity (GO:0048552)2.47318040
122peptidyl-histidine modification (GO:0018202)2.45664413
123platelet dense granule organization (GO:0060155)2.44759013
124negative regulation of myeloid cell apoptotic process (GO:0033033)2.42962385
125positive regulation of interleukin-17 production (GO:0032740)2.42786497
126nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.41300506
127L-methionine salvage (GO:0071267)2.40647367
128L-methionine biosynthetic process (GO:0071265)2.40647367
129amino acid salvage (GO:0043102)2.40647367
130regulation of T cell migration (GO:2000404)2.40542701
131cellular response to interferon-beta (GO:0035458)2.40491669
132maturation of SSU-rRNA (GO:0030490)2.39077776
133negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.37044492
134regulation of mitochondrial translation (GO:0070129)2.36224337
135mast cell activation (GO:0045576)2.34919213
136translational initiation (GO:0006413)2.34329713
137ribonucleoside triphosphate biosynthetic process (GO:0009201)2.33836922
138CTP metabolic process (GO:0046036)2.33534901
139CTP biosynthetic process (GO:0006241)2.33534901
140response to redox state (GO:0051775)2.33485550
141protein targeting to mitochondrion (GO:0006626)2.32995474
142negative regulation of chemokine production (GO:0032682)2.32348778
143regulation of cellular amino acid metabolic process (GO:0006521)2.31896345
144inner mitochondrial membrane organization (GO:0007007)2.31855276
145axon ensheathment (GO:0008366)2.29865202
146ensheathment of neurons (GO:0007272)2.29865202
147myelination (GO:0042552)2.29535516
148dopamine biosynthetic process (GO:0042416)2.27843283
149regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.26874513
150UTP biosynthetic process (GO:0006228)2.26330755
151mitochondrial calcium ion homeostasis (GO:0051560)2.24717482

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.76108495
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.34245244
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.44877650
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.88059109
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.61431882
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.39828087
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.01617813
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.92252215
9* EST1_17652178_ChIP-ChIP_JURKAT_Human2.87982653
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.82751751
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.76207493
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65802332
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.61389735
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.60589108
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60464821
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53226730
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49310390
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.49131009
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42177020
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.39330493
21XRN2_22483619_ChIP-Seq_HELA_Human2.32940811
22CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.22823260
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.15776483
24GABP_19822575_ChIP-Seq_HepG2_Human2.06856800
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.04865336
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01799992
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.99895472
28* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99714470
29* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.91902795
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90725470
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81573272
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76954964
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74998945
34TTF2_22483619_ChIP-Seq_HELA_Human1.71391697
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67695864
36VDR_23849224_ChIP-Seq_CD4+_Human1.63464643
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60303249
38* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56947139
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56252621
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.47691303
41SPI1_23547873_ChIP-Seq_NB4_Human1.46600701
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.44030551
43SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.42783845
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42429911
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.42304311
46SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.41118370
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.39026071
48ELK1_19687146_ChIP-ChIP_HELA_Human1.38450260
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37508511
50* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36110472
51ELK1_22589737_ChIP-Seq_MCF10A_Human1.36038509
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35427828
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34207048
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31966036
55YY1_22570637_ChIP-Seq_MALME-3M_Human1.30526360
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30087748
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29812936
58DCP1A_22483619_ChIP-Seq_HELA_Human1.29140702
59IRF1_19129219_ChIP-ChIP_H3396_Human1.26484840
60STAT1_20625510_ChIP-Seq_HELA_Human1.24151673
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23758224
62FOXP1_21924763_ChIP-Seq_HESCs_Human1.22239553
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20100494
64VDR_22108803_ChIP-Seq_LS180_Human1.19717630
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18792025
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.17034896
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17016657
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14206698
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13368677
70CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12920151
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12343987
72IRF8_27001747_Chip-Seq_BMDM_Mouse1.12257404
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11919202
74NANOG_20526341_ChIP-Seq_ESCs_Human1.11883991
75ZNF263_19887448_ChIP-Seq_K562_Human1.10770352
76BCL6_27268052_Chip-Seq_Bcells_Human1.10419684
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10202551
78CTCF_26484167_Chip-Seq_Bcells_Mouse1.10032674
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09467893
80* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.08868501
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.08211583
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07763907
83E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07695747
84* FOXP3_21729870_ChIP-Seq_TREG_Human1.07429146
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07392242
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07333560
87SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07312187
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07177214
89TAF15_26573619_Chip-Seq_HEK293_Human1.05132451
90MYC_18940864_ChIP-ChIP_HL60_Human1.04611426
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03739269
92* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03686232
93PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02951473
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02343565
95CTCF_20526341_ChIP-Seq_ESCs_Human1.00471230
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00017748
97CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99388540
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99314483
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98483785
100PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97451398
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96721123
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96440936
103HTT_18923047_ChIP-ChIP_STHdh_Human0.95569448
104KAP1_22055183_ChIP-Seq_ESCs_Mouse0.95495170
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95455099
106DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95210799
107CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94145773
108BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93473110
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93089450
110MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92977021
111NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92763264
112KDM5A_27292631_Chip-Seq_BREAST_Human0.91719830
113MYC_18358816_ChIP-ChIP_MESCs_Mouse0.91345262
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91299350
115TP63_19390658_ChIP-ChIP_HaCaT_Human0.90481663
116FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89629464
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89411841
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89349597
119FLI1_27457419_Chip-Seq_LIVER_Mouse0.89137164
120CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88928655
121BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87253015
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86697925
123E2F1_20622854_ChIP-Seq_HELA_Human0.86053839
124* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.86012241
125CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85759377
126CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85421858
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84726399
128PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84559153
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84230012
130SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84196601
131ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83875278
132CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83800183
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83682807
134ERG_20517297_ChIP-Seq_VCAP_Human0.83226340
135NANOG_19829295_ChIP-Seq_ESCs_Human0.82433586
136SOX2_19829295_ChIP-Seq_ESCs_Human0.82433586
137NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82145521
138AR_20517297_ChIP-Seq_VCAP_Human0.82089800
139ERA_21632823_ChIP-Seq_H3396_Human0.81731919
140YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.81650988
141GATA3_26560356_Chip-Seq_TH2_Human0.81621818
142TAL1_26923725_Chip-Seq_HPCs_Mouse0.81107187
143STAT3_18555785_Chip-Seq_ESCs_Mouse0.80730833
144EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79828429
145FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79735944
146SA1_27219007_Chip-Seq_ERYTHROID_Human0.79001457
147PHF8_20622854_ChIP-Seq_HELA_Human0.78521945
148ER_23166858_ChIP-Seq_MCF-7_Human0.78511592
149NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78062584
150SCL_19346495_ChIP-Seq_HPC-7_Human0.77349873
151SMAD1_18555785_Chip-Seq_ESCs_Mouse0.76525353
152SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76318246
153GATA3_21867929_ChIP-Seq_TH1_Mouse0.75620709
154SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75362407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology5.03260753
2MP0002234_abnormal_pharynx_morphology3.81689205
3MP0002653_abnormal_ependyma_morphology3.63605166
4MP0009379_abnormal_foot_pigmentation3.50077403
5MP0001905_abnormal_dopamine_level2.91623860
6MP0002822_catalepsy2.86535840
7MP0002148_abnormal_hypersensitivity_rea2.83762529
8MP0009785_altered_susceptibility_to2.77342550
9MP0000049_abnormal_middle_ear2.72696110
10MP0001835_abnormal_antigen_presentation2.72426524
11MP0005671_abnormal_response_to2.71785847
12MP0001529_abnormal_vocalization2.70115963
13MP0000920_abnormal_myelination2.66459077
14MP0003724_increased_susceptibility_to2.64545673
15MP0003136_yellow_coat_color2.62616415
16MP0002249_abnormal_larynx_morphology2.49401829
17MP0000678_abnormal_parathyroid_gland2.40506110
18MP0003186_abnormal_redox_activity2.30962773
19MP0005000_abnormal_immune_tolerance2.21186819
20MP0006082_CNS_inflammation2.17093228
21MP0004133_heterotaxia2.16301464
22MP0005025_abnormal_response_to2.12088436
23MP0008789_abnormal_olfactory_epithelium2.07563680
24MP0001790_abnormal_immune_system2.01499990
25MP0005387_immune_system_phenotype2.01499990
26MP0005451_abnormal_body_composition1.92478148
27MP0004381_abnormal_hair_follicle1.92348785
28MP0008932_abnormal_embryonic_tissue1.89908221
29MP0002419_abnormal_innate_immunity1.85639435
30MP0000685_abnormal_immune_system1.84738050
31MP0001986_abnormal_taste_sensitivity1.82615900
32MP0005058_abnormal_lysosome_morphology1.80830402
33MP0005394_taste/olfaction_phenotype1.79819109
34MP0005499_abnormal_olfactory_system1.79819109
35MP0002723_abnormal_immune_serum1.76681204
36MP0000372_irregular_coat_pigmentation1.74750552
37MP0005409_darkened_coat_color1.70401780
38MP0001800_abnormal_humoral_immune1.68561161
39MP0003011_delayed_dark_adaptation1.67100418
40MP0001984_abnormal_olfaction1.66394621
41MP0002282_abnormal_trachea_morphology1.65918035
42MP0004019_abnormal_vitamin_homeostasis1.64436803
43MP0003436_decreased_susceptibility_to1.63940727
44MP0005379_endocrine/exocrine_gland_phen1.62258722
45MP0002452_abnormal_antigen_presenting1.61402406
46MP0003763_abnormal_thymus_physiology1.59283045
47MP0005310_abnormal_salivary_gland1.58819609
48MP0002420_abnormal_adaptive_immunity1.58332569
49MP0008058_abnormal_DNA_repair1.57535891
50MP0001819_abnormal_immune_cell1.57001094
51MP0003880_abnormal_central_pattern1.56081803
52MP0002938_white_spotting1.55778911
53MP0004957_abnormal_blastocyst_morpholog1.53969379
54MP0003938_abnormal_ear_development1.53548461
55MP0005408_hypopigmentation1.53124737
56MP0004142_abnormal_muscle_tone1.51556521
57MP0009333_abnormal_splenocyte_physiolog1.49705275
58MP0002163_abnormal_gland_morphology1.48795872
59MP0003786_premature_aging1.46866983
60MP0004043_abnormal_pH_regulation1.45545475
61MP0001293_anophthalmia1.45113944
62MP0005377_hearing/vestibular/ear_phenot1.44728856
63MP0003878_abnormal_ear_physiology1.44728856
64MP0003950_abnormal_plasma_membrane1.44262728
65MP0003693_abnormal_embryo_hatching1.40232497
66MP0010386_abnormal_urinary_bladder1.39932755
67MP0002160_abnormal_reproductive_system1.39658955
68MP0006036_abnormal_mitochondrial_physio1.34696691
69MP0006035_abnormal_mitochondrial_morpho1.32911642
70MP0002132_abnormal_respiratory_system1.31168588
71MP0003718_maternal_effect1.30607353
72MP0002277_abnormal_respiratory_mucosa1.28428953
73MP0003806_abnormal_nucleotide_metabolis1.28150118
74MP0002405_respiratory_system_inflammati1.26061882
75MP0003195_calcinosis1.26054658
76MP0002933_joint_inflammation1.22590829
77MP0004147_increased_porphyrin_level1.21895008
78MP0006072_abnormal_retinal_apoptosis1.18347303
79MP0005075_abnormal_melanosome_morpholog1.16588778
80MP0003690_abnormal_glial_cell1.15948355
81MP0005084_abnormal_gallbladder_morpholo1.14667622
82MP0003656_abnormal_erythrocyte_physiolo1.14503359
83MP0008260_abnormal_autophagy1.13949518
84MP0001845_abnormal_inflammatory_respons1.12959500
85MP0008469_abnormal_protein_level1.12704487
86MP0008004_abnormal_stomach_pH1.12390202
87MP0000716_abnormal_immune_system1.12318407
88MP0002736_abnormal_nociception_after1.10877991
89MP0001851_eye_inflammation1.09643601
90MP0005389_reproductive_system_phenotype1.09491774
91MP0001873_stomach_inflammation1.09430248
92MP0002837_dystrophic_cardiac_calcinosis1.09183798
93MP0000566_synostosis1.08692519
94MP0005636_abnormal_mineral_homeostasis1.08687989
95MP0004742_abnormal_vestibular_system1.08493886
96MP0008875_abnormal_xenobiotic_pharmacok1.05724143
97MP0000681_abnormal_thyroid_gland1.04782926
98MP0005645_abnormal_hypothalamus_physiol1.04023636
99MP0005464_abnormal_platelet_physiology1.03927882
100MP0004782_abnormal_surfactant_physiolog1.03645224
101MP0000026_abnormal_inner_ear1.03485374
102MP0001764_abnormal_homeostasis1.02199112
103MP0001663_abnormal_digestive_system1.01363762
104MP0000762_abnormal_tongue_morphology1.01040403
105MP0002102_abnormal_ear_morphology1.01009081
106MP0001853_heart_inflammation0.99892414
107MP0010155_abnormal_intestine_physiology0.97565667
108MP0001727_abnormal_embryo_implantation0.96818526
109MP0003866_abnormal_defecation0.96460181
110MP0005381_digestive/alimentary_phenotyp0.95776955
111MP0002735_abnormal_chemical_nociception0.95771857
112MP0001533_abnormal_skeleton_physiology0.95449205
113MP0002177_abnormal_outer_ear0.94996068
114MP0005171_absent_coat_pigmentation0.93633548
115MP0001919_abnormal_reproductive_system0.93314958
116MP0000343_altered_response_to0.93312593
117MP0005332_abnormal_amino_acid0.92577665
118MP0002233_abnormal_nose_morphology0.92101645
119MP0002638_abnormal_pupillary_reflex0.91834703
120MP0005410_abnormal_fertilization0.88603790
121MP0002398_abnormal_bone_marrow0.87450681
122MP0000465_gastrointestinal_hemorrhage0.86373752
123MP0002429_abnormal_blood_cell0.85156995
124MP0001485_abnormal_pinna_reflex0.84206234
125MP0001188_hyperpigmentation0.83981727
126MP0008995_early_reproductive_senescence0.81836967
127MP0000689_abnormal_spleen_morphology0.81822768
128MP0001346_abnormal_lacrimal_gland0.80725421
129MP0000631_abnormal_neuroendocrine_gland0.78591449
130MP0000358_abnormal_cell_content/0.78360399
131MP0005164_abnormal_response_to0.77229995
132MP0006276_abnormal_autonomic_nervous0.76964385
133MP0003937_abnormal_limbs/digits/tail_de0.76777168
134MP0009764_decreased_sensitivity_to0.75191623
135MP0009840_abnormal_foam_cell0.74835708
136MP0002254_reproductive_system_inflammat0.74632023
137MP0002722_abnormal_immune_system0.73935234
138MP0008872_abnormal_physiological_respon0.73017653
139MP0002138_abnormal_hepatobiliary_system0.72847091
140MP0002272_abnormal_nervous_system0.72564081
141MP0001879_abnormal_lymphatic_vessel0.71651858
142MP0009250_abnormal_appendicular_skeleto0.70771420
143MP0002295_abnormal_pulmonary_circulatio0.70601452
144MP0001963_abnormal_hearing_physiology0.68942217
145MP0005174_abnormal_tail_pigmentation0.68525708
146MP0002876_abnormal_thyroid_physiology0.68244502
147MP0003283_abnormal_digestive_organ0.67844786
148MP0008873_increased_physiological_sensi0.67810050
149MP0005584_abnormal_enzyme/coenzyme_acti0.67291634
150MP0006292_abnormal_olfactory_placode0.67181090
151MP0003646_muscle_fatigue0.66867205
152MP0003315_abnormal_perineum_morphology0.65523930
153MP0002932_abnormal_joint_morphology0.64259423
154MP0001881_abnormal_mammary_gland0.62770617
155MP0001970_abnormal_pain_threshold0.62128480
156MP0005166_decreased_susceptibility_to0.60217944
157MP0000750_abnormal_muscle_regeneration0.58396032
158MP0005085_abnormal_gallbladder_physiolo0.57446588
159MP0001756_abnormal_urination0.56130921
160MP0003137_abnormal_impulse_conducting0.55797904
161MP0005319_abnormal_enzyme/_coenzyme0.55568414
162MP0001929_abnormal_gametogenesis0.54750734
163MP0009745_abnormal_behavioral_response0.54741594
164MP0002734_abnormal_mechanical_nocicepti0.54484289
165MP0001968_abnormal_touch/_nociception0.52694775

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.64432408
2Abnormal respiratory motile cilium physiology (HP:0012261)7.00423485
3Abnormal respiratory motile cilium morphology (HP:0005938)6.86392664
4Abnormal respiratory epithelium morphology (HP:0012253)6.86392664
5Abnormal ciliary motility (HP:0012262)6.71450723
6Dynein arm defect of respiratory motile cilia (HP:0012255)6.62880068
7Absent/shortened dynein arms (HP:0200106)6.62880068
8Rhinitis (HP:0012384)6.09138583
9Acute necrotizing encephalopathy (HP:0006965)5.22021535
10Mitochondrial inheritance (HP:0001427)5.02202502
11Chronic bronchitis (HP:0004469)4.69349716
12Abnormal mitochondria in muscle tissue (HP:0008316)4.67693344
13Increased hepatocellular lipid droplets (HP:0006565)4.57576464
14Renal Fanconi syndrome (HP:0001994)4.51592872
15Acute encephalopathy (HP:0006846)4.36148808
16Hepatocellular necrosis (HP:0001404)4.30650754
17Progressive macrocephaly (HP:0004481)4.21285914
18Nasal polyposis (HP:0100582)4.11951258
19Bronchiectasis (HP:0002110)4.10064976
20Lipid accumulation in hepatocytes (HP:0006561)4.09443779
21Increased CSF lactate (HP:0002490)4.04243779
22Hepatic necrosis (HP:0002605)3.92936151
233-Methylglutaconic aciduria (HP:0003535)3.84366630
24Double outlet right ventricle (HP:0001719)3.64836594
25Congenital malformation of the right heart (HP:0011723)3.64836594
26Parakeratosis (HP:0001036)3.62211595
27Exertional dyspnea (HP:0002875)3.61140298
28Sclerocornea (HP:0000647)3.60689404
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.59025517
30Increased intramyocellular lipid droplets (HP:0012240)3.47256418
31Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.36986314
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.36677880
33Pancreatic fibrosis (HP:0100732)3.32618774
34True hermaphroditism (HP:0010459)3.32585531
35Abnormality of the nasal mucosa (HP:0000433)3.29153018
36Abnormality of cells of the erythroid lineage (HP:0012130)3.17695928
37Abnormality of renal resorption (HP:0011038)3.07298960
38Pancreatic cysts (HP:0001737)3.05709233
39Leukodystrophy (HP:0002415)3.02021529
40Abnormal number of erythroid precursors (HP:0012131)3.00955050
41Increased muscle lipid content (HP:0009058)2.98593069
42Occipital encephalocele (HP:0002085)2.98092378
43Vacuolated lymphocytes (HP:0001922)2.96584673
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.92965284
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.92965284
46Respiratory failure (HP:0002878)2.88960976
47Optic disc pallor (HP:0000543)2.84485621
48Increased serum pyruvate (HP:0003542)2.83884497
49Abnormality of glycolysis (HP:0004366)2.83884497
50Aplasia/Hypoplasia of the sacrum (HP:0008517)2.82334732
51Chronic sinusitis (HP:0011109)2.78352146
52Cerebral edema (HP:0002181)2.76347803
53Respiratory difficulties (HP:0002880)2.75763759
54Exercise intolerance (HP:0003546)2.72026857
55Abnormality of midbrain morphology (HP:0002418)2.67744616
56Molar tooth sign on MRI (HP:0002419)2.67744616
57Congenital ichthyosiform erythroderma (HP:0007431)2.67047715
58Lactic acidosis (HP:0003128)2.63370787
59Hypoplastic left heart (HP:0004383)2.61499217
60Increased serum lactate (HP:0002151)2.60259986
61Male infertility (HP:0003251)2.53578976
62Reticulocytopenia (HP:0001896)2.47837901
63Abnormality of urine glucose concentration (HP:0011016)2.46413739
64Glycosuria (HP:0003076)2.46413739
65Infertility (HP:0000789)2.43712762
66Patchy hypopigmentation of hair (HP:0011365)2.40644689
67Macrocytic anemia (HP:0001972)2.32890325
68Cystic liver disease (HP:0006706)2.30510427
69Hepatosplenomegaly (HP:0001433)2.28827771
70Abnormality of macrophages (HP:0004311)2.27343685
71Neurofibrillary tangles (HP:0002185)2.27262811
72Elevated erythrocyte sedimentation rate (HP:0003565)2.26394116
73Purpura (HP:0000979)2.24669012
74Hyperphosphaturia (HP:0003109)2.22792197
75Abnormality of aromatic amino acid family metabolism (HP:0004338)2.22181317
76Petechiae (HP:0000967)2.18965046
77Nephronophthisis (HP:0000090)2.18197975
78Bronchitis (HP:0012387)2.16027295
79Male pseudohermaphroditism (HP:0000037)2.13339223
80Hypothermia (HP:0002045)2.12700304
81Type I transferrin isoform profile (HP:0003642)2.10974694
82Anencephaly (HP:0002323)2.08646059
83* Recurrent abscess formation (HP:0002722)2.07989674
84Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.07004419
85Hypoplasia of the uterus (HP:0000013)2.02967849
86Hypoplastic heart (HP:0001961)2.01207891
87Methylmalonic acidemia (HP:0002912)2.01069403
88Abnormality of placental membranes (HP:0011409)1.98705512
89Amniotic constriction ring (HP:0009775)1.98705512
90Partial duplication of thumb phalanx (HP:0009944)1.98618234
91White forelock (HP:0002211)1.97597095
92Recurrent sinusitis (HP:0011108)1.95121596
93Colon cancer (HP:0003003)1.94577686
94Congenital, generalized hypertrichosis (HP:0004540)1.94132537
95Atelectasis (HP:0100750)1.94114269
96Prolonged neonatal jaundice (HP:0006579)1.93507508
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.92930396
98Degeneration of the lateral corticospinal tracts (HP:0002314)1.92930396
99Renal tubular dysfunction (HP:0000124)1.90858978
100Abnormality of the axillary hair (HP:0100134)1.90338566
101Abnormality of secondary sexual hair (HP:0009888)1.90338566
102Sensory axonal neuropathy (HP:0003390)1.89214048
103Medial flaring of the eyebrow (HP:0010747)1.89173534
104Progressive neurologic deterioration (HP:0002344)1.87722435
105Aplasia/Hypoplasia of the tongue (HP:0010295)1.87214506
106Microvesicular hepatic steatosis (HP:0001414)1.87180475
107Abnormal urine phosphate concentration (HP:0012599)1.86167534
108Obstructive lung disease (HP:0006536)1.85567875
109Chronic obstructive pulmonary disease (HP:0006510)1.85567875
110Stomatitis (HP:0010280)1.85338509
111CNS demyelination (HP:0007305)1.85304500
112Tetany (HP:0001281)1.84019170
113Erythroderma (HP:0001019)1.83488883
114Congenital sensorineural hearing impairment (HP:0008527)1.82584734
115Pallor (HP:0000980)1.81820768
116Abnormal hemoglobin (HP:0011902)1.81392338
117Recurrent otitis media (HP:0000403)1.81382763
118Rough bone trabeculation (HP:0100670)1.81271609
119Congenital hepatic fibrosis (HP:0002612)1.80304415
120Abnormality of the aortic arch (HP:0012303)1.80241889
121Abnormal ventriculo-arterial connection (HP:0011563)1.78701583
122Transposition of the great arteries (HP:0001669)1.78701583
123Abnormal connection of the cardiac segments (HP:0011545)1.78701583
124IgM deficiency (HP:0002850)1.78640251
125Neutropenia (HP:0001875)1.78476190
126Poor head control (HP:0002421)1.77021607
127* Recurrent bacterial skin infections (HP:0005406)1.76638932
128Postaxial foot polydactyly (HP:0001830)1.76361135
129Periauricular skin pits (HP:0100277)1.76200752
130Preauricular pit (HP:0004467)1.76200752
131Severe combined immunodeficiency (HP:0004430)1.75955250
132Furrowed tongue (HP:0000221)1.75066920
133Cerebral hypomyelination (HP:0006808)1.74883316
134Spastic paraparesis (HP:0002313)1.74162125
135Eczematoid dermatitis (HP:0000976)1.72706927
136Abnormal protein glycosylation (HP:0012346)1.72696094
137Abnormal glycosylation (HP:0012345)1.72696094
138Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72696094
139Abnormal protein N-linked glycosylation (HP:0012347)1.72696094
140Methylmalonic aciduria (HP:0012120)1.70405523
141Gastrointestinal stroma tumor (HP:0100723)1.69832553
142Aplastic anemia (HP:0001915)1.69623705
143Abnormal hair whorl (HP:0010721)1.69504464
144Vasculitis (HP:0002633)1.69294889
145Unilateral renal agenesis (HP:0000122)1.68779974
146Aplasia/hypoplasia of the uterus (HP:0008684)1.68540953
147Chronic otitis media (HP:0000389)1.68157098
148X-linked dominant inheritance (HP:0001423)1.67692157
149Myositis (HP:0100614)1.66551574
150Increased IgM level (HP:0003496)1.64954454
151Generalized aminoaciduria (HP:0002909)1.63402470
152Aplasia/Hypoplasia of the macula (HP:0008059)1.61071750
153Abnormal pupillary function (HP:0007686)1.60710183
154Cerebral hemorrhage (HP:0001342)1.60562190
155Abnormality of the phalanges of the 2nd finger (HP:0009541)1.60241038
156Lethargy (HP:0001254)1.59754330

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK27.60217973
2TAF14.00960139
3SMG13.38484068
4STK393.29836818
5NME23.07215128
6PBK3.06216974
7MST42.58822391
8MAPKAPK52.57787677
9STK162.52279506
10OXSR12.27822029
11BMPR1B2.20443240
12IRAK42.17676401
13ARAF2.13294994
14MAP3K122.11835460
15PIM22.05296471
16TXK2.03485916
17MUSK1.98686833
18NME11.93107440
19DYRK31.83413464
20TNIK1.73335851
21CDK191.67918382
22MYLK1.63551219
23MAP4K11.55865560
24ZAK1.52671227
25CASK1.49928660
26TEC1.48642820
27IRAK31.47000319
28EPHB11.46889130
29ADRBK21.45236807
30TBK11.42435310
31WNK41.39918540
32TAOK31.39441719
33DAPK11.36184173
34MAP3K141.35907046
35PRKD31.34288643
36BCR1.33986462
37VRK11.32802848
38IKBKE1.29803913
39EPHA21.29701136
40TESK11.28805793
41TIE11.28734658
42CSNK1G31.28255379
43LIMK11.27225387
44BMPR21.25908229
45TLK11.23426389
46PKN11.22066547
47GRK71.16832400
48CDK81.11376587
49KIT1.11111908
50IKBKB1.09615082
51WNK31.06622500
52BLK1.03323235
53TTK1.01854655
54CLK11.01440417
55MAP4K21.00717581
56AURKA0.98441443
57BUB10.98298064
58IRAK10.97817217
59IRAK20.97632114
60MAP2K70.96613506
61BRAF0.94282948
62DYRK20.94256648
63MET0.92649255
64PIK3CA0.91630174
65NEK60.91323063
66RPS6KA50.90407169
67SYK0.89942422
68TESK20.89496568
69KDR0.88720763
70BTK0.87521414
71PLK30.87104071
72CSNK1G10.85606463
73EIF2AK10.85533196
74TYK20.85402951
75LYN0.84325745
76EPHB20.83895630
77ABL20.82806364
78GRK10.82095849
79CHEK20.81615185
80TRPM70.78040474
81FGR0.77982630
82PRKCQ0.76676863
83PIK3CG0.76364786
84EIF2AK30.74272924
85PRKCI0.73592147
86CAMK2B0.73244897
87BRSK10.73021682
88CSNK1A1L0.71717272
89PAK40.71557955
90LCK0.71352661
91LRRK20.70986585
92ILK0.70074233
93SRPK10.69557018
94BCKDK0.69048520
95MAP3K110.68428233
96ZAP700.68148241
97NLK0.66505085
98MAPK150.63945418
99CAMK2D0.63304952
100WEE10.61163935
101MOS0.60728745
102MAP2K20.60449076
103CAMK2G0.59368881
104MST1R0.58697750
105CSF1R0.55325547
106MAPKAPK30.54385210
107MAPK130.52017532
108ROCK20.51826170
109CSNK1G20.50164654
110MELK0.49980908
111CDK30.49896558
112STK240.49487571
113CDK90.49100088
114JAK30.48816610
115PLK10.47240797
116GRK60.46746845
117OBSCN0.46635162
118CSNK2A10.46335755
119MAPK40.46283523
120STK40.44950224
121DAPK30.44703012
122ITK0.44348194
123MAP2K60.43961367
124MAP3K130.43714860
125ADRBK10.43102221
126EIF2AK20.42995191
127CSNK2A20.42369979
128PRKCE0.42350457
129ERBB40.41798014
130PRKCD0.40937981
131AURKB0.40298180
132PRKG20.39693701
133MAPKAPK20.38493454
134GRK50.37926776
135NUAK10.37727107
136PLK40.37653444
137CCNB10.31849619
138PAK10.31694985
139CDK70.30841519
140STK100.29999823
141INSRR0.29367065
142PTK2B0.29247311
143TRIM280.27832474
144AKT20.27330171
145CSNK1A10.26680191
146TAOK20.24613236
147PASK0.21557395
148MAP3K30.20167490
149ATR0.19625928
150CDC70.19074404
151HIPK20.18491079
152BRSK20.18452211
153PDK20.16463556

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.92347539
2Protein export_Homo sapiens_hsa030604.30425054
3Parkinsons disease_Homo sapiens_hsa050124.04750924
4Ribosome_Homo sapiens_hsa030103.98825871
5Sulfur relay system_Homo sapiens_hsa041223.42788197
6Alzheimers disease_Homo sapiens_hsa050102.98888493
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.82251691
8Proteasome_Homo sapiens_hsa030502.80969906
9Huntingtons disease_Homo sapiens_hsa050162.64028671
10Fatty acid elongation_Homo sapiens_hsa000622.49433743
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.42762616
12Steroid biosynthesis_Homo sapiens_hsa001002.20049790
13RNA polymerase_Homo sapiens_hsa030202.03846932
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98957464
15Ether lipid metabolism_Homo sapiens_hsa005651.93776347
16Sulfur metabolism_Homo sapiens_hsa009201.82573196
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80215423
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.62407741
19Histidine metabolism_Homo sapiens_hsa003401.56840774
20Rheumatoid arthritis_Homo sapiens_hsa053231.53942902
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42956387
22Allograft rejection_Homo sapiens_hsa053301.42682936
23Arachidonic acid metabolism_Homo sapiens_hsa005901.37330663
24Other glycan degradation_Homo sapiens_hsa005111.36239229
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.35232268
26DNA replication_Homo sapiens_hsa030301.35109470
27Sphingolipid metabolism_Homo sapiens_hsa006001.34517493
28Linoleic acid metabolism_Homo sapiens_hsa005911.33406081
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.33007749
30Graft-versus-host disease_Homo sapiens_hsa053321.32907827
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29477938
32Autoimmune thyroid disease_Homo sapiens_hsa053201.26054676
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.25826460
34Collecting duct acid secretion_Homo sapiens_hsa049661.25447105
35Folate biosynthesis_Homo sapiens_hsa007901.23638509
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.17409991
37Asthma_Homo sapiens_hsa053101.15893818
38Cardiac muscle contraction_Homo sapiens_hsa042601.14683023
39Spliceosome_Homo sapiens_hsa030401.14070652
40Primary immunodeficiency_Homo sapiens_hsa053401.13390614
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08505561
42Glutathione metabolism_Homo sapiens_hsa004801.08017953
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07248929
44Fanconi anemia pathway_Homo sapiens_hsa034601.06407871
45Vibrio cholerae infection_Homo sapiens_hsa051101.05679500
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05408685
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04885428
48Pyrimidine metabolism_Homo sapiens_hsa002400.96985108
49Malaria_Homo sapiens_hsa051440.94638111
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92316538
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88828344
52Basal cell carcinoma_Homo sapiens_hsa052170.83981828
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81921182
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.81821024
55Lysosome_Homo sapiens_hsa041420.81607460
56Basal transcription factors_Homo sapiens_hsa030220.79524039
57Metabolic pathways_Homo sapiens_hsa011000.78605629
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78233944
59Hematopoietic cell lineage_Homo sapiens_hsa046400.76630264
60Chemical carcinogenesis_Homo sapiens_hsa052040.76411256
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73297908
62Phagosome_Homo sapiens_hsa041450.72069015
63N-Glycan biosynthesis_Homo sapiens_hsa005100.71248865
64Non-homologous end-joining_Homo sapiens_hsa034500.66275209
65Tyrosine metabolism_Homo sapiens_hsa003500.65183373
66Peroxisome_Homo sapiens_hsa041460.64712902
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64159323
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.63885395
69Pertussis_Homo sapiens_hsa051330.63853400
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.62228042
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59928085
72Leishmaniasis_Homo sapiens_hsa051400.57629762
73Arginine and proline metabolism_Homo sapiens_hsa003300.56976420
74Propanoate metabolism_Homo sapiens_hsa006400.54463837
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.53394862
76Caffeine metabolism_Homo sapiens_hsa002320.53281131
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52729346
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52685002
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52487324
80p53 signaling pathway_Homo sapiens_hsa041150.52130162
81Homologous recombination_Homo sapiens_hsa034400.51507619
82Regulation of autophagy_Homo sapiens_hsa041400.51178011
83Purine metabolism_Homo sapiens_hsa002300.50965538
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.50891829
85Staphylococcus aureus infection_Homo sapiens_hsa051500.49938013
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49647210
87Vitamin B6 metabolism_Homo sapiens_hsa007500.48829489
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47355615
89Hedgehog signaling pathway_Homo sapiens_hsa043400.46427234
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46400203
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.46319889
92Type I diabetes mellitus_Homo sapiens_hsa049400.46254738
93RNA transport_Homo sapiens_hsa030130.43201278
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42583320
95Retinol metabolism_Homo sapiens_hsa008300.42485549
96Phenylalanine metabolism_Homo sapiens_hsa003600.41555505
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41311972
98Serotonergic synapse_Homo sapiens_hsa047260.41251563
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38627334
100Fructose and mannose metabolism_Homo sapiens_hsa000510.38582213
101Biosynthesis of amino acids_Homo sapiens_hsa012300.38016074
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37981034
103Nucleotide excision repair_Homo sapiens_hsa034200.37595042
104Galactose metabolism_Homo sapiens_hsa000520.37196348
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36910371
106Carbon metabolism_Homo sapiens_hsa012000.36646505
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36057018
108One carbon pool by folate_Homo sapiens_hsa006700.35281196
109Fatty acid degradation_Homo sapiens_hsa000710.34716996
110Tryptophan metabolism_Homo sapiens_hsa003800.31992272
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29670882
112Measles_Homo sapiens_hsa051620.29423705
113African trypanosomiasis_Homo sapiens_hsa051430.28815385
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28125905
115Mineral absorption_Homo sapiens_hsa049780.27316532
116RNA degradation_Homo sapiens_hsa030180.27050799
117Legionellosis_Homo sapiens_hsa051340.24490272
118Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23799148
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23657942
120Nitrogen metabolism_Homo sapiens_hsa009100.23617718
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23157914
122Base excision repair_Homo sapiens_hsa034100.23107175
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22777709
124Pyruvate metabolism_Homo sapiens_hsa006200.22408829
125Mismatch repair_Homo sapiens_hsa034300.21312938
126beta-Alanine metabolism_Homo sapiens_hsa004100.20374451
127Tuberculosis_Homo sapiens_hsa051520.19988760
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.19347405
129Vitamin digestion and absorption_Homo sapiens_hsa049770.19320700
130Phototransduction_Homo sapiens_hsa047440.18834498
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.18731879
132Pentose phosphate pathway_Homo sapiens_hsa000300.18716487
133Antigen processing and presentation_Homo sapiens_hsa046120.18394813
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.17711442
135Butanoate metabolism_Homo sapiens_hsa006500.17578712
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17201656
137Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16561151

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