PSG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The human placenta is a multihormonal endocrine organ that produces hormones, enzymes, and other molecules that support fetal survival and development. Pregnancy-specific beta-1-glycoprotein (PSBG, PSG) is a major product of the syncytiotrophoblast, reaching concentrations of 100 to 290 mg/l at term in the serum of pregnant women (Horne et al., 1976 [PubMed 971765]). PSG is a member of the immunoglobulin (Ig) superfamily (Watanabe and Chou, 1988 [PubMed 3257488]; Streydio et al., 1988 [PubMed 3260773]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1androgen biosynthetic process (GO:0006702)9.14058426
2* multi-multicellular organism process (GO:0044706)8.32981529
3androgen metabolic process (GO:0008209)8.10780765
4positive regulation of growth hormone secretion (GO:0060124)7.31356910
5* multi-organism reproductive process (GO:0044703)7.24749262
6glucocorticoid metabolic process (GO:0008211)6.47157477
7hormone biosynthetic process (GO:0042446)5.92105851
8myoblast fusion (GO:0007520)5.59810912
9positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-5.53118235
10response to gonadotropin (GO:0034698)5.34689212
11regulation of growth hormone secretion (GO:0060123)5.34375875
12vascular endothelial growth factor signaling pathway (GO:0038084)5.31372472
13syncytium formation (GO:0006949)5.12217185
14JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)5.08711584
15syncytium formation by plasma membrane fusion (GO:0000768)4.97312206
16endocrine hormone secretion (GO:0060986)4.95182788
17collecting duct development (GO:0072044)4.82296615
18positive regulation of protein kinase C signaling (GO:0090037)4.77110808
19lymphangiogenesis (GO:0001946)4.71872663
20sphingoid metabolic process (GO:0046519)4.61026829
21sequestering of extracellular ligand from receptor (GO:0035581)4.59297985
22negative regulation of activin receptor signaling pathway (GO:0032926)4.56743050
23vitamin transmembrane transport (GO:0035461)4.43803074
24lymph vessel development (GO:0001945)4.21744764
25bone morphogenesis (GO:0060349)4.07218400
26sprouting angiogenesis (GO:0002040)4.03714188
27vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.93848013
28type B pancreatic cell proliferation (GO:0044342)3.63750909
29parturition (GO:0007567)3.47444164
30cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.43418329
31bone trabecula formation (GO:0060346)3.38412334
32basement membrane organization (GO:0071711)3.38242955
33eyelid development in camera-type eye (GO:0061029)3.36134466
34collagen fibril organization (GO:0030199)3.28266279
35positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.05606589
36myelin maintenance (GO:0043217)3.04796600
37regulation of interferon-gamma biosynthetic process (GO:0045072)3.02964026
38protein heterotrimerization (GO:0070208)3.00169588
39estrogen biosynthetic process (GO:0006703)26.1299851
40blood vessel maturation (GO:0001955)2.96859514
41extracellular negative regulation of signal transduction (GO:1900116)2.96538720
42extracellular regulation of signal transduction (GO:1900115)2.96538720
43cellular response to vitamin (GO:0071295)2.94561119
44skin morphogenesis (GO:0043589)2.91150005
45JAK-STAT cascade (GO:0007259)2.88838397
46T-helper 1 type immune response (GO:0042088)2.85816144
47iron ion import (GO:0097286)2.85657628
48protein neddylation (GO:0045116)2.85405212
49cellular hormone metabolic process (GO:0034754)2.83154832
50negative regulation of cell-matrix adhesion (GO:0001953)2.80824342
51regulation of integrin-mediated signaling pathway (GO:2001044)2.79884450
52C21-steroid hormone biosynthetic process (GO:0006700)2.78252949
53progesterone metabolic process (GO:0042448)2.75484767
54positive regulation of cartilage development (GO:0061036)2.75478651
55mesenchymal-epithelial cell signaling (GO:0060638)2.75374583
56mitotic cytokinesis (GO:0000281)2.73846206
57regulation of G0 to G1 transition (GO:0070316)2.73559854
58adhesion of symbiont to host (GO:0044406)2.71569914
59endodermal cell differentiation (GO:0035987)2.70876702
60regulation of endocrine process (GO:0044060)2.68346062
61cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.67027141
62adhesion of symbiont to host cell (GO:0044650)2.66226999
63virion attachment to host cell (GO:0019062)2.66226999
64sphingosine metabolic process (GO:0006670)2.64029450
65polarized epithelial cell differentiation (GO:0030859)2.61048949
66cytoskeleton-dependent cytokinesis (GO:0061640)2.59370518
67blood vessel morphogenesis (GO:0048514)2.58595620
68positive regulation of insulin receptor signaling pathway (GO:0046628)2.57127803
69interkinetic nuclear migration (GO:0022027)2.53818127
70negative regulation of smooth muscle cell differentiation (GO:0051151)2.50511014
71extracellular matrix assembly (GO:0085029)2.42544268
72regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.40401596
73wound healing, spreading of epidermal cells (GO:0035313)2.39476742
74hyaluronan catabolic process (GO:0030214)2.35570559
75regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.35422750
76regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.34645904
77L-alpha-amino acid transmembrane transport (GO:1902475)2.34189536
78regulation of protein kinase C signaling (GO:0090036)2.31977436
79fibroblast migration (GO:0010761)2.27757679
80diol metabolic process (GO:0034311)2.27497343
81steroid biosynthetic process (GO:0006694)2.25584947
82positive regulation of p38MAPK cascade (GO:1900745)2.23280197
83positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.22294796
84negative regulation of myoblast differentiation (GO:0045662)2.20776023
85adherens junction assembly (GO:0034333)2.20602533
86import into cell (GO:0098657)2.20544299
87keratinocyte development (GO:0003334)2.20272724
88cell migration involved in heart development (GO:0060973)2.19949111
89negative regulation of smooth muscle cell migration (GO:0014912)2.19198754
90negative regulation of BMP signaling pathway (GO:0030514)2.18924348
91insulin-like growth factor receptor signaling pathway (GO:0048009)2.18124353
92smooth muscle tissue development (GO:0048745)2.15662577
93cellular response to vitamin D (GO:0071305)2.14984325
94negative regulation of osteoblast proliferation (GO:0033689)2.13359208
95response to follicle-stimulating hormone (GO:0032354)12.5391654
96regulation of gonadotropin secretion (GO:0032276)11.7698563
97* female pregnancy (GO:0007565)11.5407722
98estrogen metabolic process (GO:0008210)11.4171050
99glucocorticoid biosynthetic process (GO:0006704)10.8864328
100prostate gland growth (GO:0060736)10.3100631

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.96236832
2* EGR1_19032775_ChIP-ChIP_M12_Human3.02210219
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.92589542
4BRD4_25478319_ChIP-Seq_HGPS_Human2.66004501
5CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.59469570
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.57732418
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.53142567
8AHR_22903824_ChIP-Seq_MCF-7_Human2.37039907
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.30153020
10PPAR_26484153_Chip-Seq_NCI-H1993_Human2.22815055
11* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.18283394
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.15999857
13* TRIM28_17542650_ChIP-ChIP_NTERA2_Human2.15467587
14* TP53_18474530_ChIP-ChIP_U2OS_Human2.13577650
15ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.12889104
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.12340094
17* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.09040013
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human10.2036787
19CJUN_26792858_Chip-Seq_BT549_Human1.98254511
20ARNT_22903824_ChIP-Seq_MCF-7_Human1.92040951
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87500759
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.74634254
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.70179164
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69201148
25HIF1A_21447827_ChIP-Seq_MCF-7_Human1.64867246
26* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.64439167
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61706507
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61706507
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.60821248
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58322907
31CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.54988582
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.52403541
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51722791
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49651018
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49651018
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.46466104
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.45552635
38ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44454114
39JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41588810
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39833135
41ZNF263_19887448_ChIP-Seq_K562_Human1.35514519
42RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33873811
43PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.33223317
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32890899
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28010410
46SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27147295
47SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27147295
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25145551
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25037487
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24950089
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24323725
52SOX2_20726797_ChIP-Seq_SW620_Human1.23941188
53RXR_22108803_ChIP-Seq_LS180_Human1.22921125
54VDR_24787735_ChIP-Seq_THP-1_Human1.20494286
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20040192
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16453981
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.15850104
58* TP63_23658742_ChIP-Seq_EP156T_Human1.15494117
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14239606
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.12373956
61SA1_22415368_ChIP-Seq_MEFs_Mouse1.09663457
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08422371
63CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07061057
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.06611031
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06211215
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03983540
67GATA3_24758297_ChIP-Seq_MCF-7_Human1.03120135
68UBF1/2_26484160_Chip-Seq_HMECs_Human1.03085704
69ISL1_27105846_Chip-Seq_CPCs_Mouse1.00775618
70TP63_17297297_ChIP-ChIP_HaCaT_Human1.00353407
71FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00334773
72TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00326528
73TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99878368
74SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99247659
75SMAD3_21741376_ChIP-Seq_HESCs_Human0.98673045
76RNF2_27304074_Chip-Seq_ESCs_Mouse0.96660161
77TP53_16413492_ChIP-PET_HCT116_Human0.96135892
78JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95974172
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95199561
80SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91796268
81ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90277864
82JUN_21703547_ChIP-Seq_K562_Human0.88887041
83TBX20_22328084_ChIP-Seq_HEART_Mouse0.87376740
84TBX20_22080862_ChIP-Seq_HEART_Mouse0.87376740
85SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86524644
86SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85965527
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85030229
88EGR1_19374776_ChIP-ChIP_THP-1_Human0.84783985
89SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.84431591
90ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83899580
91FOXA2_19822575_ChIP-Seq_HepG2_Human0.83504570
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81611436
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81189311
94P300_19829295_ChIP-Seq_ESCs_Human0.81086990
95FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77993956
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77721665
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77497270
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77370763
99WT1_25993318_ChIP-Seq_PODOCYTE_Human0.77349170
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.76092306

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation9.17264802
2MP0002163_abnormal_gland_morphology5.37802883
3MP0008438_abnormal_cutaneous_collagen4.74592362
4MP0010368_abnormal_lymphatic_system3.99476045
5MP0005379_endocrine/exocrine_gland_phen3.82314932
6MP0006276_abnormal_autonomic_nervous3.75843559
7MP0006054_spinal_hemorrhage3.49548992
8MP0000013_abnormal_adipose_tissue3.22015180
9MP0003941_abnormal_skin_development3.00896021
10MP0005647_abnormal_sex_gland2.93715924
11MP0003705_abnormal_hypodermis_morpholog2.84526037
12MP0001958_emphysema2.70643536
13MP0001919_abnormal_reproductive_system2.66316469
14MP0005503_abnormal_tendon_morphology2.61493184
15MP0004272_abnormal_basement_membrane2.57263485
16MP0005275_abnormal_skin_tensile2.38926234
17MP0000003_abnormal_adipose_tissue2.29792136
18MP0003950_abnormal_plasma_membrane2.13068033
19MP0003959_abnormal_lean_body2.06992328
20MP0003279_aneurysm2.01970128
21MP0005023_abnormal_wound_healing1.93316264
22MP0009384_cardiac_valve_regurgitation1.91166202
23MP0001440_abnormal_grooming_behavior1.87899268
24MP0005389_reproductive_system_phenotype1.59909665
25MP0003566_abnormal_cell_adhesion1.57787205
26MP0004019_abnormal_vitamin_homeostasis1.57371789
27MP0002876_abnormal_thyroid_physiology1.54814326
28MP0002295_abnormal_pulmonary_circulatio1.53015485
29MP0005257_abnormal_intraocular_pressure1.51177024
30MP0001879_abnormal_lymphatic_vessel1.49129734
31MP0009115_abnormal_fat_cell1.45896969
32MP0002998_abnormal_bone_remodeling1.44934060
33MP0001666_abnormal_nutrient_absorption1.33831826
34MP0006138_congestive_heart_failure1.33394306
35MP0003936_abnormal_reproductive_system1.33259540
36MP0000613_abnormal_salivary_gland1.30885169
37MP0002971_abnormal_brown_adipose1.27373685
38MP0010352_gastrointestinal_tract_polyps1.27031238
39MP0000639_abnormal_adrenal_gland1.27012514
40MP0009780_abnormal_chondrocyte_physiolo1.21355305
41MP0003091_abnormal_cell_migration1.20141144
42MP0001542_abnormal_bone_strength1.15529651
43MP0001243_abnormal_dermal_layer1.09380359
44MP0001756_abnormal_urination1.08474933
45MP0000767_abnormal_smooth_muscle1.07194064
46MP0002108_abnormal_muscle_morphology1.00794245
47MP0002128_abnormal_blood_circulation1.00446967
48MP0005375_adipose_tissue_phenotype0.99573798
49MP0009703_decreased_birth_body0.99266662
50MP0000647_abnormal_sebaceous_gland0.98253893
51MP0002060_abnormal_skin_morphology0.96098021
52MP0002075_abnormal_coat/hair_pigmentati0.94976772
53MP0010386_abnormal_urinary_bladder0.94454274
54MP0003385_abnormal_body_wall0.91985018
55MP0003453_abnormal_keratinocyte_physiol0.89708993
56MP0010329_abnormal_lipoprotein_level0.88357218
57MP0004947_skin_inflammation0.87591760
58MP0000681_abnormal_thyroid_gland0.85892564
59MP0003191_abnormal_cellular_cholesterol0.85474559
60MP0000230_abnormal_systemic_arterial0.84835077
61MP0003795_abnormal_bone_structure0.83165991
62MP0000759_abnormal_skeletal_muscle0.80894712
63MP0000534_abnormal_ureter_morphology0.80750030
64MP0002653_abnormal_ependyma_morphology0.80622255
65MP0001915_intracranial_hemorrhage0.77528976
66MP0005508_abnormal_skeleton_morphology0.74990231
67MP0002896_abnormal_bone_mineralization0.69761678
68MP0001299_abnormal_eye_distance/0.69018964
69MP0005595_abnormal_vascular_smooth0.67348930
70MP0004085_abnormal_heartbeat0.65657225
71MP0000751_myopathy0.65189653
72MP0001186_pigmentation_phenotype0.64425086
73MP0005334_abnormal_fat_pad0.62816943
74MP0005164_abnormal_response_to0.61414748
75MP0004858_abnormal_nervous_system0.61141097
76MP0001348_abnormal_lacrimal_gland0.57458654
77MP0003828_pulmonary_edema0.56137557
78MP0001340_abnormal_eyelid_morphology0.55818852
79MP0002972_abnormal_cardiac_muscle0.55650707
80MP0005623_abnormal_meninges_morphology0.55131788
81MP0000685_abnormal_immune_system0.53618811
82MP0003448_altered_tumor_morphology0.50626805
83MP0002086_abnormal_extraembryonic_tissu0.50144480
84MP0001614_abnormal_blood_vessel0.49361344
85MP0002113_abnormal_skeleton_development0.49067108
86MP0003115_abnormal_respiratory_system0.48228726
87MP0002909_abnormal_adrenal_gland0.47351592
88MP0005165_increased_susceptibility_to0.46237586
89MP0009250_abnormal_appendicular_skeleto0.44937839
90MP0002557_abnormal_social/conspecific_i0.43735084
91MP0002115_abnormal_skeleton_extremities0.41753778
92MP0000367_abnormal_coat/_hair0.41587596
93MP0002925_abnormal_cardiovascular_devel0.41123313
94MP0000266_abnormal_heart_morphology0.40538067
95MP0004510_myositis0.39306469
96MP0001765_abnormal_ion_homeostasis0.38867243
97MP0004883_abnormal_blood_vessel0.38374261
98MP0005319_abnormal_enzyme/_coenzyme0.37396979
99MP0003942_abnormal_urinary_system0.37151744
100MP0002133_abnormal_respiratory_system0.36041708

Predicted human phenotypes

RankGene SetZ-score
1Capillary hemangiomas (HP:0005306)6.00045052
2Nonimmune hydrops fetalis (HP:0001790)5.71845146
3Premature rupture of membranes (HP:0001788)5.69078279
4Protrusio acetabuli (HP:0003179)5.66132012
5Upper limb muscle weakness (HP:0003484)5.60397814
6Hypergonadotropic hypogonadism (HP:0000815)5.43581870
7Decreased number of large peripheral myelinated nerve fibers (HP:0003387)5.24926462
8Aortic aneurysm (HP:0004942)4.98304202
9Wormian bones (HP:0002645)4.62989599
10Aortic dissection (HP:0002647)3.93984266
11Accelerated skeletal maturation (HP:0005616)3.87798864
12Abnormal pupillary function (HP:0007686)3.78858726
13Vascular tortuosity (HP:0004948)3.76859595
14Muscle fibrillation (HP:0010546)3.70010994
15Fragile skin (HP:0001030)3.68728125
16Ankle contracture (HP:0006466)3.61340841
17Abnormal auditory evoked potentials (HP:0006958)3.60321506
18Tongue fasciculations (HP:0001308)3.58758317
19Soft skin (HP:0000977)3.52117259
20Blue sclerae (HP:0000592)3.36509271
21Back pain (HP:0003418)3.33671810
22Broad metatarsal (HP:0001783)3.22961665
23Follicular hyperkeratosis (HP:0007502)3.15627785
24Dilatation of the ascending aorta (HP:0005111)3.13327644
25Arterial tortuosity (HP:0005116)3.00773623
26Osteolytic defects of the phalanges of the hand (HP:0009771)2.98690667
27Osteolytic defects of the hand bones (HP:0009699)2.98690667
28Bladder diverticulum (HP:0000015)2.93701966
29Anosmia (HP:0000458)2.93014756
30Disproportionate tall stature (HP:0001519)2.86436420
31Sparse lateral eyebrow (HP:0005338)2.83950356
32Overgrowth (HP:0001548)2.80990413
33Shallow orbits (HP:0000586)2.80394236
34Atrophic scars (HP:0001075)2.72516313
35Neonatal short-limb short stature (HP:0008921)2.71948321
36Female pseudohermaphroditism (HP:0010458)2.71118025
37Cardiovascular calcification (HP:0011915)2.69951581
38Genu valgum (HP:0002857)2.68083319
39Delayed gross motor development (HP:0002194)2.63807929
40Type 1 muscle fiber predominance (HP:0003803)2.62062507
41Elbow flexion contracture (HP:0002987)2.59603906
42Long palpebral fissure (HP:0000637)2.59037480
43Flat cornea (HP:0007720)2.55800642
44Morphological abnormality of the middle ear (HP:0008609)2.53838802
45Abnormality of dentin (HP:0010299)2.53362409
46Vertebral compression fractures (HP:0002953)2.53328758
47Cervical subluxation (HP:0003308)2.53306083
48Venous insufficiency (HP:0005293)2.50031548
49Abnormality of glycolipid metabolism (HP:0010969)2.48124472
50Abnormality of liposaccharide metabolism (HP:0010968)2.48124472
51Abnormality of glycosphingolipid metabolism (HP:0004343)2.48124472
52Spondylolisthesis (HP:0003302)2.41503653
53Abnormality of the ischium (HP:0003174)2.41417521
54Peritonitis (HP:0002586)2.39791156
55Long eyelashes (HP:0000527)2.39524926
56Spinal rigidity (HP:0003306)2.38378222
57Mitral valve prolapse (HP:0001634)2.36894069
58Cerebral aneurysm (HP:0004944)2.35310463
59Mitral regurgitation (HP:0001653)2.30505465
60Venous abnormality (HP:0002624)2.27805049
61Gynecomastia (HP:0000771)2.27378036
62Onion bulb formation (HP:0003383)2.24961645
63Bowel diverticulosis (HP:0005222)2.24706727
64Coronal craniosynostosis (HP:0004440)2.23720743
65Genu recurvatum (HP:0002816)2.23124261
66Hypoplasia of the iris (HP:0007676)2.22660547
67Aneurysm (HP:0002617)2.21167362
68Aortic valve stenosis (HP:0001650)2.20130794
69Lower limb asymmetry (HP:0100559)2.13966075
70Slender build (HP:0001533)2.12161697
71Protruding ear (HP:0000411)2.11560971
72Redundant skin (HP:0001582)2.11027831
73Knee flexion contracture (HP:0006380)2.09589692
74Increased connective tissue (HP:0009025)2.09312697
75Polycythemia (HP:0001901)2.08732228
76Mitral stenosis (HP:0001718)2.06684601
77Aplasia of the musculature (HP:0100854)2.02134881
78Tarsal synostosis (HP:0008368)1.94965113
79Distal lower limb muscle weakness (HP:0009053)1.93878719
80Aortic regurgitation (HP:0001659)1.93147470
81Congenital ichthyosiform erythroderma (HP:0007431)1.91838569
82Joint laxity (HP:0001388)1.91070986
83Increased variability in muscle fiber diameter (HP:0003557)1.90433757
84Pseudobulbar signs (HP:0002200)1.90397945
85Areflexia of lower limbs (HP:0002522)1.88861051
86Abnormality of the acetabulum (HP:0003170)1.87142079
87Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.86418299
88Arachnodactyly (HP:0001166)1.84999245
89Hypogonadotrophic hypogonadism (HP:0000044)1.84823716
90Difficulty walking (HP:0002355)1.83428679
91Wide anterior fontanel (HP:0000260)1.82983847
92Biconcave vertebral bodies (HP:0004586)1.81129058
93Vascular calcification (HP:0004934)1.81080106
94Ectopia lentis (HP:0001083)1.78890673
95Mildly elevated creatine phosphokinase (HP:0008180)1.76020538
96Pectus carinatum (HP:0000768)1.75696355
97Basal cell carcinoma (HP:0002671)1.75261637
98Bilateral sensorineural hearing impairment (HP:0008619)1.75023178
99Decreased motor nerve conduction velocity (HP:0003431)1.74968288
100Hip contracture (HP:0003273)1.74774424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR7.85019463
2PDGFRA6.87448555
3AKT35.78694558
4MYLK3.53089179
5DAPK23.35138532
6NEK92.96168319
7PDGFRB2.64210632
8ICK2.27867038
9BLK1.72157061
10ERBB41.72142568
11MET1.48615690
12PAK21.47163948
13RIPK11.45597504
14TGFBR21.45349805
15STK381.44501839
16MST41.43881303
17DAPK31.42149637
18LATS11.34098962
19PRKD21.33489961
20DDR21.28140259
21TRPM71.25370374
22MST1R1.24910841
23TIE11.24820621
24PKN11.23223303
25EPHB21.19625455
26PTK21.16757765
27DAPK11.15125305
28RPS6KA21.12540230
29CDC42BPA1.08016068
30INSR0.94174772
31SRC0.92244206
32TTN0.90452868
33PDPK10.89886823
34MAP3K70.87751848
35FRK0.81052840
36TYK20.79542623
37MAP3K120.76212175
38TRIB30.75930767
39KIT0.75850106
40PTK2B0.74962006
41EPHA20.74820127
42INSRR0.74080057
43LATS20.74074178
44ADRBK10.74067397
45RPS6KL10.69914096
46RPS6KC10.69914096
47RPS6KA60.67593961
48MTOR0.63326961
49EGFR0.62693059
50NTRK10.62557769
51ROCK10.62081325
52PTK60.61356489
53ERN10.54863732
54MAP2K10.54373380
55PAK40.54274452
56PRKD10.50108633
57PRKCE0.49881689
58MELK0.49544182
59MAPK110.48618173
60GRK70.47097727
61BMX0.46210931
62ROCK20.46181918
63ABL20.45717786
64PIK3CG0.44728635
65PRKG20.44461521
66MARK20.44391703
67AKT20.43484779
68ILK0.39082517
69ADRBK20.37914141
70AURKB0.36528830
71GRK50.35279101
72CAMK2G0.34427251
73STK100.33630562
74PKN20.32649974
75STK30.32465020
76LIMK10.31745011
77MAPK70.31369602
78MAPK40.30434471
79JAK10.30100133
80MOS0.29556049
81FLT30.29498318
82MAP3K30.28416976
83BRSK20.27785678
84PDK10.27525293
85CDK80.27238413
86MAP3K60.27008654
87DYRK1B0.26908085
88PAK60.25872442
89PRKCZ0.25749395
90TBK10.25737907
91TESK10.24783067
92PLK20.24054812
93SIK10.23831241
94JAK20.22633208
95PRKCA0.21882543
96PIK3CA0.20392750
97ERBB30.18350178
98MAPK10.17142026
99PRKCH0.10937756
100SGK2230.10266224

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049137.49972849
2Steroid hormone biosynthesis_Homo sapiens_hsa001406.59111588
3Jak-STAT signaling pathway_Homo sapiens_hsa046303.43159843
4ECM-receptor interaction_Homo sapiens_hsa045122.62873785
5PI3K-Akt signaling pathway_Homo sapiens_hsa041512.32634752
6Focal adhesion_Homo sapiens_hsa045102.14689106
7Sphingolipid metabolism_Homo sapiens_hsa006002.04860832
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.01138510
9N-Glycan biosynthesis_Homo sapiens_hsa005101.97771600
10Aldosterone synthesis and secretion_Homo sapiens_hsa049251.87735452
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.84385116
12Renin-angiotensin system_Homo sapiens_hsa046141.81258332
13Folate biosynthesis_Homo sapiens_hsa007901.70351380
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66700193
15Mineral absorption_Homo sapiens_hsa049781.53149073
16Proteoglycans in cancer_Homo sapiens_hsa052051.30235349
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25044276
18Axon guidance_Homo sapiens_hsa043601.22040181
19Other glycan degradation_Homo sapiens_hsa005111.19284828
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15253754
21Ras signaling pathway_Homo sapiens_hsa040141.13527301
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09789911
23Bladder cancer_Homo sapiens_hsa052191.07790517
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07513675
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04368647
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02830727
27Malaria_Homo sapiens_hsa051441.00756361
28Protein digestion and absorption_Homo sapiens_hsa049740.99431951
29Amoebiasis_Homo sapiens_hsa051460.97705996
30Inositol phosphate metabolism_Homo sapiens_hsa005620.95968692
31Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95373331
32Salivary secretion_Homo sapiens_hsa049700.94933998
33Prolactin signaling pathway_Homo sapiens_hsa049170.94674949
34Adherens junction_Homo sapiens_hsa045200.93042353
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92233386
36Renal cell carcinoma_Homo sapiens_hsa052110.89366019
37Small cell lung cancer_Homo sapiens_hsa052220.88153660
38Rap1 signaling pathway_Homo sapiens_hsa040150.87049698
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83259523
40Sphingolipid signaling pathway_Homo sapiens_hsa040710.82685375
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81426538
42TGF-beta signaling pathway_Homo sapiens_hsa043500.79688004
43Dorso-ventral axis formation_Homo sapiens_hsa043200.78045533
44Lysosome_Homo sapiens_hsa041420.77919334
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77716480
46Tight junction_Homo sapiens_hsa045300.75453049
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71721197
48Pathways in cancer_Homo sapiens_hsa052000.71683462
49Complement and coagulation cascades_Homo sapiens_hsa046100.71046137
50Dilated cardiomyopathy_Homo sapiens_hsa054140.70621769
51Histidine metabolism_Homo sapiens_hsa003400.67601316
52Hippo signaling pathway_Homo sapiens_hsa043900.66504300
53Endocytosis_Homo sapiens_hsa041440.65935448
54Melanoma_Homo sapiens_hsa052180.65292333
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62968884
56MicroRNAs in cancer_Homo sapiens_hsa052060.62401195
57Prostate cancer_Homo sapiens_hsa052150.61480095
58Thyroid hormone synthesis_Homo sapiens_hsa049180.60306249
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60234598
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.57424448
61Platelet activation_Homo sapiens_hsa046110.56449335
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.54961018
63Chronic myeloid leukemia_Homo sapiens_hsa052200.48466038
64Tryptophan metabolism_Homo sapiens_hsa003800.48199058
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46188866
66Vitamin digestion and absorption_Homo sapiens_hsa049770.45746015
67Insulin resistance_Homo sapiens_hsa049310.41946639
68FoxO signaling pathway_Homo sapiens_hsa040680.41944819
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.40571716
70MAPK signaling pathway_Homo sapiens_hsa040100.40102789
71Melanogenesis_Homo sapiens_hsa049160.39755484
72GnRH signaling pathway_Homo sapiens_hsa049120.38809114
73HIF-1 signaling pathway_Homo sapiens_hsa040660.37704538
74Gap junction_Homo sapiens_hsa045400.37445327
75Phagosome_Homo sapiens_hsa041450.36787931
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34808566
77TNF signaling pathway_Homo sapiens_hsa046680.34561209
78p53 signaling pathway_Homo sapiens_hsa041150.34450102
79Hepatitis B_Homo sapiens_hsa051610.32099650
80Glioma_Homo sapiens_hsa052140.32089073
81ErbB signaling pathway_Homo sapiens_hsa040120.31692516
82Hedgehog signaling pathway_Homo sapiens_hsa043400.31252656
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30881434
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.30538334
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30471195
86Estrogen signaling pathway_Homo sapiens_hsa049150.30129780
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29568436
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28134671
89Hepatitis C_Homo sapiens_hsa051600.28006857
90Toxoplasmosis_Homo sapiens_hsa051450.27545199
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25016405
92African trypanosomiasis_Homo sapiens_hsa051430.23826984
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23354121
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23248202
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22233155
96Gastric acid secretion_Homo sapiens_hsa049710.21170198
97Pancreatic cancer_Homo sapiens_hsa052120.19826194
98Choline metabolism in cancer_Homo sapiens_hsa052310.19168381
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.18644551
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.18501722

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