PSG10P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1monoubiquitinated protein deubiquitination (GO:0035520)7.83436810
2outer ear morphogenesis (GO:0042473)7.73793797
3regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)6.67321383
4regulation of dopamine uptake involved in synaptic transmission (GO:0051584)6.67321383
5artery development (GO:0060840)6.25984438
6facial nerve structural organization (GO:0021612)5.47640368
7embryonic skeletal joint morphogenesis (GO:0060272)5.09714328
8endocardial cushion development (GO:0003197)4.89352089
9icosanoid secretion (GO:0032309)4.77042621
10arachidonic acid secretion (GO:0050482)4.77042621
11endosome to melanosome transport (GO:0035646)4.75509394
12endosome to pigment granule transport (GO:0043485)4.75509394
13kidney mesenchyme development (GO:0072074)4.72095836
14metanephric mesenchyme development (GO:0072075)4.44716288
15regulation of neurotransmitter uptake (GO:0051580)4.40400754
16cell migration involved in heart development (GO:0060973)4.29229162
17hyaluronan catabolic process (GO:0030214)4.28492231
18mesenchymal-epithelial cell signaling (GO:0060638)4.28356943
19musculoskeletal movement (GO:0050881)4.27309594
20multicellular organismal movement (GO:0050879)4.27309594
21heparan sulfate proteoglycan biosynthetic process (GO:0015012)4.23835781
22prepulse inhibition (GO:0060134)4.22660162
23pericardium development (GO:0060039)4.17040454
24polyamine biosynthetic process (GO:0006596)4.12215489
25negative regulation of sodium ion transport (GO:0010766)4.11237696
26protein K48-linked deubiquitination (GO:0071108)4.05313806
27behavioral response to cocaine (GO:0048148)4.00500729
28regulation of proton transport (GO:0010155)3.89868500
29low-density lipoprotein particle clearance (GO:0034383)3.88920118
30G-protein coupled receptor internalization (GO:0002031)3.88736974
31synaptic transmission, dopaminergic (GO:0001963)3.87654032
32icosanoid transport (GO:0071715)3.84029566
33fatty acid derivative transport (GO:1901571)3.84029566
34base-excision repair, AP site formation (GO:0006285)3.80757974
35cranial nerve structural organization (GO:0021604)3.80684314
36negative regulation of membrane potential (GO:0045837)3.76976902
37negative regulation of nitric-oxide synthase activity (GO:0051001)3.72269749
38positive regulation of endothelial cell differentiation (GO:0045603)3.64199345
39platelet dense granule organization (GO:0060155)3.63731464
40water-soluble vitamin biosynthetic process (GO:0042364)3.63544998
41cochlea morphogenesis (GO:0090103)3.54438287
42regulation of interleukin-8 secretion (GO:2000482)3.53787017
43eyelid development in camera-type eye (GO:0061029)3.52631165
44cellular biogenic amine biosynthetic process (GO:0042401)3.48985232
45response to redox state (GO:0051775)3.48703604
46positive regulation of gastrulation (GO:2000543)3.46438033
47estrogen biosynthetic process (GO:0006703)3.39173949
48response to histamine (GO:0034776)3.36316418
49protein import into peroxisome matrix (GO:0016558)3.36222730
50regulation of synaptic transmission, dopaminergic (GO:0032225)3.22266968
51smooth muscle tissue development (GO:0048745)3.22167034
52amine biosynthetic process (GO:0009309)3.21883964
53embryonic forelimb morphogenesis (GO:0035115)3.15632077
54positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.12659773
55regulation of secondary heart field cardioblast proliferation (GO:0003266)3.11056919
56regulation of cardioblast proliferation (GO:0003264)3.11056919
57regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.09383445
58fibroblast migration (GO:0010761)3.07771379
59negative regulation of protein autophosphorylation (GO:0031953)3.05611831
60middle ear morphogenesis (GO:0042474)3.03702729
61ovulation cycle (GO:0042698)3.03217515
62endocrine hormone secretion (GO:0060986)3.01366839
63misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.00662222
64positive regulation of cellular amine metabolic process (GO:0033240)2.96095349
65fatty acid homeostasis (GO:0055089)2.94487673
66regulation of transforming growth factor beta1 production (GO:0032908)2.93968705
67mesonephros development (GO:0001823)2.91797597
68regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.91107113
69C21-steroid hormone biosynthetic process (GO:0006700)2.90807229
70reflex (GO:0060004)2.86406957
71head development (GO:0060322)2.85756012
72positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.82229550
73adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.79234731
74pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.76729648
75adipose tissue development (GO:0060612)2.74663247
76negative regulation of synaptic transmission, GABAergic (GO:0032229)2.73260229
77regulation of mitochondrial translation (GO:0070129)2.71138217
78natural killer cell mediated immunity (GO:0002228)2.69597137
79natural killer cell mediated cytotoxicity (GO:0042267)2.69597137
80skin morphogenesis (GO:0043589)2.69446598
81positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.67862467
82regulation of endothelial cell differentiation (GO:0045601)2.65035056
83connective tissue development (GO:0061448)2.64904848
84forelimb morphogenesis (GO:0035136)2.63941205
85heparan sulfate proteoglycan metabolic process (GO:0030201)2.62338262
86regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.60322994
87lipopolysaccharide biosynthetic process (GO:0009103)2.58604061
88negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.56328169
89cellular biogenic amine catabolic process (GO:0042402)2.55967925
90amine catabolic process (GO:0009310)2.55967925
91purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.53458416
923-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.53458416
93female pregnancy (GO:0007565)2.53147053
94positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.52598383
95ventricular septum development (GO:0003281)2.52306579
96parental behavior (GO:0060746)2.50447604
97membrane raft organization (GO:0031579)2.49993010
98early endosome to late endosome transport (GO:0045022)2.48933219
99pattern specification involved in kidney development (GO:0061004)2.48717306
100regulation of fibroblast migration (GO:0010762)2.48372419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse7.02696216
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.57712238
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.26057152
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.03803947
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.99284468
6CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.88845256
7CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.73765903
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.71955103
9TP53_18474530_ChIP-ChIP_U2OS_Human2.54877650
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.54164585
11CJUN_26792858_Chip-Seq_BT549_Human2.44290480
12ZNF274_21170338_ChIP-Seq_K562_Hela2.41617100
13BRD4_25478319_ChIP-Seq_HGPS_Human2.27657455
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24756904
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.22042074
16GBX2_23144817_ChIP-Seq_PC3_Human2.20664782
17TP53_16413492_ChIP-PET_HCT116_Human2.16853007
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.07761960
19JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.05940557
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.03870004
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.90872798
22JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.89240574
23NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.88503788
24NRF2_20460467_ChIP-Seq_MEFs_Mouse1.88503788
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.78996247
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.64371066
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.64371066
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.60084159
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.59689704
30RXR_22108803_ChIP-Seq_LS180_Human1.59099961
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58382724
32ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.49303283
33RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.47015781
34SOX2_20726797_ChIP-Seq_SW620_Human1.46892129
35P63_26484246_Chip-Seq_KERATINOCYTES_Human1.43389746
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39643017
37CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39084347
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37207013
39VDR_22108803_ChIP-Seq_LS180_Human1.34629757
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.30725448
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29744817
42GATA1_22025678_ChIP-Seq_K562_Human1.29313339
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27296439
44GATA4_25053715_ChIP-Seq_YYC3_Human1.22194634
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20927637
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19528568
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.18645777
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18457503
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17933626
50TP63_23658742_ChIP-Seq_EP156T_Human1.17897769
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.15209266
52CSB_26484114_Chip-Seq_FIBROBLAST_Human1.14413537
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14022198
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07862780
55EGR1_19032775_ChIP-ChIP_M12_Human1.07501905
56MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06663670
57JUN_21703547_ChIP-Seq_K562_Human1.05265924
58STAT3_23295773_ChIP-Seq_U87_Human1.04413509
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03874906
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.03279336
61NANOG_19829295_ChIP-Seq_ESCs_Human1.02268354
62SOX2_19829295_ChIP-Seq_ESCs_Human1.02268354
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.02202269
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01940136
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01187141
66SMAD4_21799915_ChIP-Seq_A2780_Human1.00190127
67TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98014068
68EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96977723
69ESR1_20079471_ChIP-ChIP_T-47D_Human0.95920686
70AR_25329375_ChIP-Seq_VCAP_Human0.95808305
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95603940
72TP53_23651856_ChIP-Seq_MEFs_Mouse0.93693935
73P300_19829295_ChIP-Seq_ESCs_Human0.92618301
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.91735145
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89414542
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88451959
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88213940
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86827089
79NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86805244
80SMAD4_21741376_ChIP-Seq_EPCs_Human0.86069802
81FOXA1_25329375_ChIP-Seq_VCAP_Human0.85085116
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85085116
83NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84663109
84BCAT_22108803_ChIP-Seq_LS180_Human0.84182358
85CDX2_22108803_ChIP-Seq_LS180_Human0.83160092
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82556443
87HOXB7_26014856_ChIP-Seq_BT474_Human0.82455398
88TCF4_23295773_ChIP-Seq_U87_Human0.82426637
89FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82278687
90CBP_20019798_ChIP-Seq_JUKART_Human0.81839909
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81839909
92FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.81475267
93POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80818411
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80729041
95PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.79909386
96ETV2_25802403_ChIP-Seq_MESCs_Mouse0.79792079
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.78910273
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78812971
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77945596
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77474383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition5.99686168
2MP0003646_muscle_fatigue5.49322704
3MP0005503_abnormal_tendon_morphology4.25692639
4MP0003950_abnormal_plasma_membrane3.88387388
5MP0004272_abnormal_basement_membrane3.18104566
6MP0008438_abnormal_cutaneous_collagen3.03143227
7MP0002837_dystrophic_cardiac_calcinosis2.88543435
8MP0001542_abnormal_bone_strength2.57127117
9MP0003941_abnormal_skin_development2.56781188
10MP0001905_abnormal_dopamine_level2.50593425
11MP0002736_abnormal_nociception_after2.37171374
12MP0009046_muscle_twitch2.33228724
13MP0003195_calcinosis2.23009380
14MP0010386_abnormal_urinary_bladder2.22767809
15MP0000538_abnormal_urinary_bladder2.03335938
16MP0002295_abnormal_pulmonary_circulatio1.92809795
17MP0002735_abnormal_chemical_nociception1.88530500
18MP0002108_abnormal_muscle_morphology1.86691065
19MP0008875_abnormal_xenobiotic_pharmacok1.83743392
20MP0003705_abnormal_hypodermis_morpholog1.82810055
21MP0005023_abnormal_wound_healing1.81037972
22MP0000678_abnormal_parathyroid_gland1.79172969
23MP0008775_abnormal_heart_ventricle1.76842365
24MP0003806_abnormal_nucleotide_metabolis1.62796567
25MP0010368_abnormal_lymphatic_system1.61446150
26MP0005275_abnormal_skin_tensile1.58015208
27MP0003252_abnormal_bile_duct1.55889438
28MP0003122_maternal_imprinting1.55565706
29MP0001958_emphysema1.52030590
30MP0005257_abnormal_intraocular_pressure1.50890585
31MP0001756_abnormal_urination1.49223266
32MP0006054_spinal_hemorrhage1.48434406
33MP0005508_abnormal_skeleton_morphology1.46432900
34MP0009780_abnormal_chondrocyte_physiolo1.43706250
35MP0001299_abnormal_eye_distance/1.42884153
36MP0001968_abnormal_touch/_nociception1.41842446
37MP0001440_abnormal_grooming_behavior1.41701446
38MP0004133_heterotaxia1.39103133
39MP0000230_abnormal_systemic_arterial1.36820834
40MP0002928_abnormal_bile_duct1.35905869
41MP0004130_abnormal_muscle_cell1.35477973
42MP0001486_abnormal_startle_reflex1.34365746
43MP0003191_abnormal_cellular_cholesterol1.30100190
44MP0001529_abnormal_vocalization1.29885995
45MP0005408_hypopigmentation1.29512533
46MP0003942_abnormal_urinary_system1.28083361
47MP0008872_abnormal_physiological_respon1.27726301
48MP0009250_abnormal_appendicular_skeleto1.24039099
49MP0000537_abnormal_urethra_morphology1.21449305
50MP0000049_abnormal_middle_ear1.21091364
51MP0002877_abnormal_melanocyte_morpholog1.18054725
52MP0001853_heart_inflammation1.17713564
53MP0002876_abnormal_thyroid_physiology1.16706235
54MP0000681_abnormal_thyroid_gland1.15550955
55MP0002177_abnormal_outer_ear1.13179040
56MP0009384_cardiac_valve_regurgitation1.12468482
57MP0010352_gastrointestinal_tract_polyps1.08718574
58MP0010030_abnormal_orbit_morphology1.05798136
59MP0001270_distended_abdomen1.04856308
60MP0005595_abnormal_vascular_smooth1.03476921
61MP0003279_aneurysm1.00198594
62MP0003755_abnormal_palate_morphology0.98164994
63MP0005084_abnormal_gallbladder_morpholo0.97645340
64MP0002163_abnormal_gland_morphology0.95863618
65MP0001970_abnormal_pain_threshold0.95769320
66MP0005332_abnormal_amino_acid0.95186535
67MP0005187_abnormal_penis_morphology0.94987472
68MP0004924_abnormal_behavior0.91977493
69MP0005386_behavior/neurological_phenoty0.91977493
70MP0000015_abnormal_ear_pigmentation0.90557502
71MP0003186_abnormal_redox_activity0.89825227
72MP0002733_abnormal_thermal_nociception0.89355584
73MP0000003_abnormal_adipose_tissue0.89240151
74MP0009697_abnormal_copulation0.88795257
75MP0000343_altered_response_to0.86644292
76MP0000647_abnormal_sebaceous_gland0.86105001
77MP0000372_irregular_coat_pigmentation0.85292602
78MP0001348_abnormal_lacrimal_gland0.81904865
79MP0005220_abnormal_exocrine_pancreas0.76569259
80MP0001984_abnormal_olfaction0.75420101
81MP0005367_renal/urinary_system_phenotyp0.74247624
82MP0000516_abnormal_urinary_system0.74247624
83MP0000639_abnormal_adrenal_gland0.71573007
84MP0002796_impaired_skin_barrier0.71106768
85MP0005360_urolithiasis0.70945880
86MP0005174_abnormal_tail_pigmentation0.70915715
87MP0003937_abnormal_limbs/digits/tail_de0.70526722
88MP0005164_abnormal_response_to0.70133308
89MP0005646_abnormal_pituitary_gland0.70059517
90MP0005390_skeleton_phenotype0.69097150
91MP0005620_abnormal_muscle_contractility0.66793884
92MP0003890_abnormal_embryonic-extraembry0.66697760
93MP0004742_abnormal_vestibular_system0.65509846
94MP0000427_abnormal_hair_cycle0.64122360
95MP0010771_integument_phenotype0.58905008
96MP0002168_other_aberrant_phenotype0.57924945
97MP0000534_abnormal_ureter_morphology0.57367590
98MP0002136_abnormal_kidney_physiology0.57011603
99MP0009840_abnormal_foam_cell0.55859125
100MP0003315_abnormal_perineum_morphology0.55312527

Predicted human phenotypes

RankGene SetZ-score
1Cutaneous melanoma (HP:0012056)8.82394077
2Short nail (HP:0001799)7.16534604
3Spinal cord compression (HP:0002176)6.22395035
4Ovoid vertebral bodies (HP:0003300)5.81936399
5Broad distal phalanx of finger (HP:0009836)5.46898495
611 pairs of ribs (HP:0000878)5.09057602
7Flared iliac wings (HP:0002869)4.99455975
8Radial bowing (HP:0002986)4.55387444
9Meningioma (HP:0002858)4.29885452
10Cupped ribs (HP:0000887)4.28026923
11Delayed gross motor development (HP:0002194)4.19634962
12Irregular vertebral endplates (HP:0003301)4.02189678
13Fragile skin (HP:0001030)3.78878622
14Abnormality of carpal bone ossification (HP:0006257)3.74035081
15Soft skin (HP:0000977)3.68063158
16Exostoses (HP:0100777)3.60721423
17Hypoplastic ischia (HP:0003175)3.52200391
18Hydroxyprolinuria (HP:0003080)3.31815197
19Abnormality of proline metabolism (HP:0010907)3.31815197
20Abnormality of the ischium (HP:0003174)3.17986435
21Short femoral neck (HP:0100864)3.12840502
22Bowed forearm bones (HP:0003956)3.06136517
23Bowing of the arm (HP:0006488)3.06136517
24Broad metatarsal (HP:0001783)2.97715227
25Aortic aneurysm (HP:0004942)2.91429739
26Abnormality of the vertebral endplates (HP:0005106)2.91412478
27Albinism (HP:0001022)2.83149421
28Congenital, generalized hypertrichosis (HP:0004540)2.81484697
29Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.80635513
30Methylmalonic aciduria (HP:0012120)2.79160867
31Abnormality of liposaccharide metabolism (HP:0010968)2.79078174
32Abnormality of glycosphingolipid metabolism (HP:0004343)2.79078174
33Abnormality of glycolipid metabolism (HP:0010969)2.79078174
34Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.67258421
35Methylmalonic acidemia (HP:0002912)2.65408720
36Melanoma (HP:0002861)2.61337437
37Abnormal hand bone ossification (HP:0010660)2.59958749
38Bicuspid aortic valve (HP:0001647)2.57531041
39Abnormal ossification of hand bones (HP:0005921)2.54855680
40Coxa valga (HP:0002673)2.54681094
41Cardiovascular calcification (HP:0011915)2.53411946
42Missing ribs (HP:0000921)2.49733168
43Vascular calcification (HP:0004934)2.49261007
44Mitral regurgitation (HP:0001653)2.48399443
45Coronal craniosynostosis (HP:0004440)2.45182124
46Mesomelia (HP:0003027)2.44768161
47Premature rupture of membranes (HP:0001788)2.42807418
48Deviation of the hallux (HP:0010051)2.42247641
49Dislocated radial head (HP:0003083)2.41859204
50Hyperglycinemia (HP:0002154)2.40999706
51Mesangial abnormality (HP:0001966)2.40766312
52Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.40675216
53Vascular tortuosity (HP:0004948)2.35088598
54Hallux valgus (HP:0001822)2.32211969
55Metatarsus adductus (HP:0001840)2.29812000
56Abnormality of the radial head (HP:0003995)2.26166733
57Hypoplasia of the uterus (HP:0000013)2.25375434
58Aplasia/hypoplasia of the femur (HP:0005613)2.18209579
59Furrowed tongue (HP:0000221)2.17936603
60Slender long bone (HP:0003100)2.10070855
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.09772624
62Abnormality of the wing of the ilium (HP:0011867)2.07294232
63Aplasia/Hypoplasia of the tongue (HP:0010295)2.06183204
64Aplasia of the musculature (HP:0100854)2.04030012
65Microglossia (HP:0000171)2.03879783
66Flat face (HP:0012368)2.01495165
67Congenital primary aphakia (HP:0007707)2.00652987
68Lymphangioma (HP:0100764)1.98421688
69Gait imbalance (HP:0002141)1.96334565
70Absent phalangeal crease (HP:0006109)1.96286778
71Benign neoplasm of the central nervous system (HP:0100835)1.93815517
72Large for gestational age (HP:0001520)1.92562561
73Neoplasm of the lung (HP:0100526)1.90540072
74Pathologic fracture (HP:0002756)1.87397755
75Partial duplication of the phalanx of hand (HP:0009999)1.87206169
76Aortic dissection (HP:0002647)1.86691475
77Craniofacial hyperostosis (HP:0004493)1.85701406
78Cervical subluxation (HP:0003308)1.83993948
79Enlarged penis (HP:0000040)1.79210784
80Abnormal vertebral ossification (HP:0100569)1.78667991
81Glucose intolerance (HP:0000833)1.78360187
82True hermaphroditism (HP:0010459)1.77588415
83Buphthalmos (HP:0000557)1.76971936
84Abnormality of dentin (HP:0010299)1.76405893
85Asymmetric septal hypertrophy (HP:0001670)1.76356976
86Protrusio acetabuli (HP:0003179)1.75865572
87Sparse scalp hair (HP:0002209)1.75562305
88Blue sclerae (HP:0000592)1.75128796
89Dysostosis multiplex (HP:0000943)1.74898132
90Medial flaring of the eyebrow (HP:0010747)1.74414255
91Ectopia lentis (HP:0001083)1.74055283
92Hypophosphatemic rickets (HP:0004912)1.72114461
93Severe short stature (HP:0003510)1.70789279
94Conical tooth (HP:0000698)1.70165197
95Vertebral compression fractures (HP:0002953)1.69327764
96Spondylolisthesis (HP:0003302)1.67848776
97Supernumerary nipples (HP:0002558)1.66505521
98Nephrogenic diabetes insipidus (HP:0009806)1.65975839
99Hamartoma of the eye (HP:0010568)1.65826122
100Bell-shaped thorax (HP:0001591)1.65128676

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.80260481
2MYLK4.91850986
3ACVR1B3.72267986
4TRPM73.01893518
5MAP3K122.86946358
6GRK72.72981051
7ADRBK22.43037043
8MAP3K22.42002580
9NEK92.38772342
10LIMK12.32329597
11MAP3K132.27768142
12EPHA22.27649656
13GRK12.18430081
14MAPKAPK32.15253711
15PAK22.00622128
16EPHB21.85638818
17NTRK31.83384216
18BMPR1B1.79760331
19DDR21.76771861
20KSR21.74112134
21PAK61.73762568
22FGFR21.64889610
23WNK11.62923792
24MET1.61395523
25TGFBR11.55814177
26TLK11.49642971
27NEK11.44266089
28ADRBK11.38060724
29RAF11.36302871
30PTK2B1.35305910
31MAP2K11.26649116
32PLK21.24010621
33PTK21.22410234
34AKT31.18984891
35MST1R1.15621910
36PAK31.15130420
37KSR11.14220882
38EEF2K1.11873186
39NUAK11.10507322
40ROCK11.09841861
41FLT31.08849580
42PDGFRA1.04098667
43ERBB41.01608300
44ABL20.98883940
45NTRK10.93262887
46ILK0.88617581
47TIE10.85984761
48JAK10.85129302
49BCKDK0.84824460
50BRSK20.81597927
51MAPKAPK50.80512200
52ERBB30.79489378
53NEK20.75225592
54ZAK0.74728491
55PRKD20.74483525
56MAP3K30.73623851
57CSNK1A1L0.72319698
58CAMK2G0.71558111
59PRKCE0.69958678
60MAP3K70.68605970
61STK38L0.68189743
62LATS20.66549007
63CSNK1G30.63789373
64PKN10.60591999
65PLK30.57644779
66PRKAA20.56301790
67STK160.56014776
68PIM20.55286337
69PDGFRB0.54754261
70KDR0.51095689
71MAPK130.48380689
72PIK3CA0.47644967
73RIPK10.46812098
74DAPK30.45937275
75CSNK1G10.44710811
76BRSK10.42740349
77MELK0.39913139
78CAMK2D0.39808117
79PIK3CG0.39287979
80FER0.38406167
81CSNK1G20.36906512
82TGFBR20.36704285
83CDK80.36553879
84PINK10.36322702
85STK380.35038453
86IKBKB0.34509211
87RET0.31087714
88PRKD10.31049467
89CAMK2B0.30834091
90PBK0.30062272
91PRKCI0.28269149
92PRKCQ0.27862571
93KIT0.27047145
94STK240.26547068
95MARK10.26082596
96FGFR10.25896784
97GRK50.23068880
98CAMK2A0.21226818
99PAK10.20141224
100INSR0.19643802

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005345.45452762
2Selenocompound metabolism_Homo sapiens_hsa004505.01792958
3Sulfur metabolism_Homo sapiens_hsa009204.36344869
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.23625655
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.69061152
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.38306727
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.20613865
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.16956362
9Glycerolipid metabolism_Homo sapiens_hsa005611.83911280
10Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.81255010
11Fatty acid elongation_Homo sapiens_hsa000621.78318278
12Phototransduction_Homo sapiens_hsa047441.78216752
13Regulation of autophagy_Homo sapiens_hsa041401.64634010
14ECM-receptor interaction_Homo sapiens_hsa045121.57219477
15Other glycan degradation_Homo sapiens_hsa005111.55730601
16Peroxisome_Homo sapiens_hsa041461.54865868
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49263327
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45949781
19Sphingolipid metabolism_Homo sapiens_hsa006001.44283175
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30191974
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.29039144
22Ovarian steroidogenesis_Homo sapiens_hsa049131.28379902
23Nitrogen metabolism_Homo sapiens_hsa009101.27238021
24Glutathione metabolism_Homo sapiens_hsa004801.24733676
25Lysosome_Homo sapiens_hsa041421.23011053
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21937555
27Fatty acid biosynthesis_Homo sapiens_hsa000611.18975470
28Fat digestion and absorption_Homo sapiens_hsa049751.16622007
29Melanoma_Homo sapiens_hsa052181.11052641
30Renin-angiotensin system_Homo sapiens_hsa046141.09975618
31N-Glycan biosynthesis_Homo sapiens_hsa005101.07890686
32Mineral absorption_Homo sapiens_hsa049781.07003365
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06667443
34Circadian rhythm_Homo sapiens_hsa047101.06284315
35Steroid hormone biosynthesis_Homo sapiens_hsa001400.98341765
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96623084
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90370572
38ABC transporters_Homo sapiens_hsa020100.89769266
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89211845
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86352402
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85501416
42Ether lipid metabolism_Homo sapiens_hsa005650.78991613
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78408115
44Cocaine addiction_Homo sapiens_hsa050300.73547940
45Chemical carcinogenesis_Homo sapiens_hsa052040.73029657
46Focal adhesion_Homo sapiens_hsa045100.71689783
47Tryptophan metabolism_Homo sapiens_hsa003800.70760953
48TGF-beta signaling pathway_Homo sapiens_hsa043500.69083352
49Galactose metabolism_Homo sapiens_hsa000520.68396603
50Hippo signaling pathway_Homo sapiens_hsa043900.63626616
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60789830
52Proteasome_Homo sapiens_hsa030500.59647342
53Calcium signaling pathway_Homo sapiens_hsa040200.59445974
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.58673101
55PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57280677
56p53 signaling pathway_Homo sapiens_hsa041150.57067889
57Type II diabetes mellitus_Homo sapiens_hsa049300.56703490
58Sulfur relay system_Homo sapiens_hsa041220.55109026
59Folate biosynthesis_Homo sapiens_hsa007900.53503472
60Endocytosis_Homo sapiens_hsa041440.51606881
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.50979065
62Collecting duct acid secretion_Homo sapiens_hsa049660.50369590
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50042766
64Retinol metabolism_Homo sapiens_hsa008300.49078205
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48865069
66Tyrosine metabolism_Homo sapiens_hsa003500.48793739
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46951490
68Protein digestion and absorption_Homo sapiens_hsa049740.46461472
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46423628
70One carbon pool by folate_Homo sapiens_hsa006700.46260676
71Fatty acid degradation_Homo sapiens_hsa000710.45481565
72PPAR signaling pathway_Homo sapiens_hsa033200.44002953
73Metabolic pathways_Homo sapiens_hsa011000.42595506
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42449789
75Proteoglycans in cancer_Homo sapiens_hsa052050.38676438
76Cholinergic synapse_Homo sapiens_hsa047250.36005525
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35966014
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35739755
79Fatty acid metabolism_Homo sapiens_hsa012120.34560014
80Base excision repair_Homo sapiens_hsa034100.31302273
81Vibrio cholerae infection_Homo sapiens_hsa051100.30204304
82Pyrimidine metabolism_Homo sapiens_hsa002400.29876231
83Phagosome_Homo sapiens_hsa041450.29683245
84Gastric acid secretion_Homo sapiens_hsa049710.29496795
85Basal cell carcinoma_Homo sapiens_hsa052170.29284850
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29106294
87Dopaminergic synapse_Homo sapiens_hsa047280.28404958
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.27861376
89Shigellosis_Homo sapiens_hsa051310.27218693
90Tight junction_Homo sapiens_hsa045300.26576700
91Bladder cancer_Homo sapiens_hsa052190.23935587
92Arginine and proline metabolism_Homo sapiens_hsa003300.23479484
93Linoleic acid metabolism_Homo sapiens_hsa005910.23378342
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22798692
95Morphine addiction_Homo sapiens_hsa050320.21656134
96Thyroid hormone synthesis_Homo sapiens_hsa049180.20773477
97Malaria_Homo sapiens_hsa051440.20583368
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19213766
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18728972
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.18175667

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