PSG11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1androgen metabolic process (GO:0008209)9.76790613
2* multi-multicellular organism process (GO:0044706)9.59789391
3positive regulation of growth hormone secretion (GO:0060124)9.14319669
4* multi-organism reproductive process (GO:0044703)8.34192475
5glucocorticoid metabolic process (GO:0008211)7.76679093
6hormone biosynthetic process (GO:0042446)7.26119497
7vitamin transmembrane transport (GO:0035461)6.70724339
8regulation of growth hormone secretion (GO:0060123)6.47150523
9myoblast fusion (GO:0007520)6.20106196
10collecting duct development (GO:0072044)6.19052913
11response to gonadotropin (GO:0034698)6.07508311
12positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-6.02665478
13JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)5.98723424
14syncytium formation (GO:0006949)5.83175837
15syncytium formation by plasma membrane fusion (GO:0000768)5.47459173
16positive regulation of protein kinase C signaling (GO:0090037)5.40213535
17negative regulation of activin receptor signaling pathway (GO:0032926)5.20612778
18endocrine hormone secretion (GO:0060986)5.13922722
19lymphangiogenesis (GO:0001946)5.11242117
20sphingoid metabolic process (GO:0046519)5.06298877
21vascular endothelial growth factor signaling pathway (GO:0038084)4.74644500
22cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.35769568
23bone morphogenesis (GO:0060349)4.10244034
24estrogen biosynthetic process (GO:0006703)31.6237006
25lymph vessel development (GO:0001945)3.99650215
26parturition (GO:0007567)3.93922212
27T-helper 1 type immune response (GO:0042088)3.85378324
28positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.80600754
29regulation of interferon-gamma biosynthetic process (GO:0045072)3.78169118
30protein neddylation (GO:0045116)3.70241746
31myelin maintenance (GO:0043217)3.65720443
32cellular hormone metabolic process (GO:0034754)3.58408789
33interkinetic nuclear migration (GO:0022027)3.48740448
34vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.41062673
35sequestering of extracellular ligand from receptor (GO:0035581)3.39355048
36sprouting angiogenesis (GO:0002040)3.32628640
37regulation of G0 to G1 transition (GO:0070316)3.30487796
38regulation of endocrine process (GO:0044060)3.29410824
39L-alpha-amino acid transmembrane transport (GO:1902475)3.25204155
40keratinocyte development (GO:0003334)3.16784272
41JAK-STAT cascade (GO:0007259)3.13783347
42negative regulation of smooth muscle cell differentiation (GO:0051151)3.04174701
43positive regulation of insulin receptor signaling pathway (GO:0046628)3.02865086
44eyelid development in camera-type eye (GO:0061029)3.00053653
45iron ion import (GO:0097286)2.97793874
46progesterone metabolic process (GO:0042448)2.90974090
47steroid biosynthetic process (GO:0006694)2.83454405
48C21-steroid hormone biosynthetic process (GO:0006700)2.81478522
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.68577361
50transcytosis (GO:0045056)2.66600406
51establishment of protein localization to Golgi (GO:0072600)2.65787037
52protein targeting to Golgi (GO:0000042)2.64607650
53basement membrane organization (GO:0071711)2.60687473
54negative regulation of cell-matrix adhesion (GO:0001953)2.60193505
55sphingosine metabolic process (GO:0006670)2.53773411
56hormone metabolic process (GO:0042445)2.49526293
57retrograde transport, vesicle recycling within Golgi (GO:0000301)2.48563341
58polarized epithelial cell differentiation (GO:0030859)2.46056864
59mitotic cytokinesis (GO:0000281)2.42916252
60regulation of ruffle assembly (GO:1900027)2.41853681
61regulation of protein kinase C signaling (GO:0090036)2.40079401
62ear development (GO:0043583)2.38320512
63regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.31837243
64ketone biosynthetic process (GO:0042181)2.31685661
65cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.24665696
66negative regulation of macrophage differentiation (GO:0045650)2.21621408
67cytoskeleton-dependent cytokinesis (GO:0061640)2.20952456
68positive regulation of alpha-beta T cell proliferation (GO:0046641)2.20575525
69Sertoli cell development (GO:0060009)2.20130349
70diol metabolic process (GO:0034311)2.19804366
71blood vessel morphogenesis (GO:0048514)2.10916084
72Leydig cell differentiation (GO:0033327)2.10586328
73regulation of calcium ion-dependent exocytosis (GO:0017158)2.07914693
74extracellular regulation of signal transduction (GO:1900115)2.05549197
75extracellular negative regulation of signal transduction (GO:1900116)2.05549197
76regulation of activin receptor signaling pathway (GO:0032925)2.04770800
77response to follicle-stimulating hormone (GO:0032354)14.9880104
78regulation of gonadotropin secretion (GO:0032276)13.9109117
79estrogen metabolic process (GO:0008210)13.7663688
80* female pregnancy (GO:0007565)13.2549734
81glucocorticoid biosynthetic process (GO:0006704)13.1785679
82prostate gland growth (GO:0060736)12.8105315
83androgen biosynthetic process (GO:0006702)11.1370535
84response to inactivity (GO:0014854)1.99253510
85vitamin D metabolic process (GO:0042359)1.97843438
86protein localization to Golgi apparatus (GO:0034067)1.97005718
87positive regulation of cellular response to insulin stimulus (GO:1900078)1.96826848
88regulation of clathrin-mediated endocytosis (GO:2000369)1.96713659
89positive regulation of cartilage development (GO:0061036)1.96042087
90C21-steroid hormone metabolic process (GO:0008207)1.95831556
91regulation of hippo signaling (GO:0035330)1.94061867
92female genitalia development (GO:0030540)1.94005965
93negative regulation of myoblast differentiation (GO:0045662)1.93004618
94import into cell (GO:0098657)1.92753281
95apical protein localization (GO:0045176)1.91259868
96cellular response to gonadotropin stimulus (GO:0071371)1.90920282
97thyroid hormone generation (GO:0006590)1.90558069
98response to vitamin E (GO:0033197)1.90011426
99response to phenylpropanoid (GO:0080184)1.89825154
100regulation of alpha-beta T cell proliferation (GO:0046640)1.89045461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19032775_ChIP-ChIP_M12_Human5.56334989
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.40046956
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.89841689
4BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.87865508
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.84338569
6AHR_22903824_ChIP-Seq_MCF-7_Human2.71845923
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.53962993
8* TRIM28_17542650_ChIP-ChIP_NTERA2_Human2.47381958
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.45357135
10ARNT_22903824_ChIP-Seq_MCF-7_Human2.26933569
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.20745147
12PPAR_26484153_Chip-Seq_NCI-H1993_Human2.15013469
13CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.12005048
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06209825
15* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human10.3252650
16* TP53_18474530_ChIP-ChIP_U2OS_Human1.93782290
17ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.85584870
18* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82813959
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.73916449
20* BRD4_25478319_ChIP-Seq_HGPS_Human1.71883158
21* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.70763639
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.68083192
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61807253
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.61178327
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56188393
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56065190
27SCL_19346495_ChIP-Seq_HPC-7_Human1.55792627
28ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52592192
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.50125460
30ER_23166858_ChIP-Seq_MCF-7_Human1.49963808
31AR_21572438_ChIP-Seq_LNCaP_Human1.49589253
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44734137
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44734137
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42405067
35ZNF263_19887448_ChIP-Seq_K562_Human1.40111253
36CJUN_26792858_Chip-Seq_BT549_Human1.39845167
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.33889744
38P300_19829295_ChIP-Seq_ESCs_Human1.31474575
39RXR_22108803_ChIP-Seq_LS180_Human1.31460468
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31108265
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30139339
42TP63_23658742_ChIP-Seq_EP156T_Human1.29803835
43VDR_24787735_ChIP-Seq_THP-1_Human1.28551018
44GATA3_24758297_ChIP-Seq_MCF-7_Human1.28324627
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.26125494
46CBP_20019798_ChIP-Seq_JUKART_Human1.25752759
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25752759
48TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24439692
49PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.24343547
50FUS_26573619_Chip-Seq_HEK293_Human1.17823374
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14434883
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14434883
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14143028
54SMAD3_21741376_ChIP-Seq_HESCs_Human1.14128803
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13608124
56IGF1R_20145208_ChIP-Seq_DFB_Human1.12780838
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12462214
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12179395
59SOX2_19829295_ChIP-Seq_ESCs_Human1.11859018
60NANOG_19829295_ChIP-Seq_ESCs_Human1.11859018
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08860945
62SOX2_20726797_ChIP-Seq_SW620_Human1.03455705
63ERG_20517297_ChIP-Seq_VCAP_Human1.02998529
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02733739
65NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02531444
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02531444
67JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02280470
68TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00286511
69TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00028974
70FOXA1_25329375_ChIP-Seq_VCAP_Human0.99463046
71FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99463046
72JUN_21703547_ChIP-Seq_K562_Human0.98821865
73JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97554531
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97523042
75CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97308136
76GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95683884
77AR_19668381_ChIP-Seq_PC3_Human0.95577429
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93874804
79ISL1_27105846_Chip-Seq_CPCs_Mouse0.92013550
80* RUNX2_22187159_ChIP-Seq_PCA_Human0.91362571
81TCF4_23295773_ChIP-Seq_U87_Human0.90667268
82GATA4_25053715_ChIP-Seq_YYC3_Human0.90541555
83FOXA2_19822575_ChIP-Seq_HepG2_Human0.90276073
84RNF2_27304074_Chip-Seq_ESCs_Mouse0.90154376
85TAF15_26573619_Chip-Seq_HEK293_Human0.87568873
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87564319
87* KLF4_19829295_ChIP-Seq_ESCs_Human0.85802243
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85719275
89CDX2_22108803_ChIP-Seq_LS180_Human0.85525700
90GATA1_19941826_ChIP-Seq_K562_Human0.85475470
91MTF2_20144788_ChIP-Seq_MESCs_Mouse0.84824085
92FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84268661
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83847530
94SMAD4_21741376_ChIP-Seq_HESCs_Human0.83137549
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82512234
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82512234
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82471256
98SOX2_21211035_ChIP-Seq_LN229_Gbm0.81688117
99AR_25329375_ChIP-Seq_VCAP_Human0.80555515
100* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80116901

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology6.97233231
2MP0005379_endocrine/exocrine_gland_phen5.55966765
3MP0006276_abnormal_autonomic_nervous4.86570856
4MP0005647_abnormal_sex_gland3.89913723
5MP0010368_abnormal_lymphatic_system3.70186527
6MP0001919_abnormal_reproductive_system3.56457140
7MP0000013_abnormal_adipose_tissue2.99825885
8MP0003959_abnormal_lean_body2.63346995
9MP0001440_abnormal_grooming_behavior2.60535793
10MP0003941_abnormal_skin_development2.52996278
11MP0000003_abnormal_adipose_tissue2.40377788
12MP0004019_abnormal_vitamin_homeostasis2.32721836
13MP0006054_spinal_hemorrhage2.24480718
14MP0005389_reproductive_system_phenotype2.09165724
15MP0009697_abnormal_copulation11.6279070
16MP0002876_abnormal_thyroid_physiology1.94389900
17MP0009115_abnormal_fat_cell1.77597745
18MP0001666_abnormal_nutrient_absorption1.74504447
19MP0002653_abnormal_ependyma_morphology1.60556124
20MP0003936_abnormal_reproductive_system1.56784389
21MP0000639_abnormal_adrenal_gland1.55856237
22MP0006138_congestive_heart_failure1.52557261
23MP0002971_abnormal_brown_adipose1.50280915
24MP0000613_abnormal_salivary_gland1.46213034
25MP0001879_abnormal_lymphatic_vessel1.37113982
26MP0000647_abnormal_sebaceous_gland1.35392086
27MP0010329_abnormal_lipoprotein_level1.34482183
28MP0009703_decreased_birth_body1.30980944
29MP0002998_abnormal_bone_remodeling1.30363831
30MP0003950_abnormal_plasma_membrane1.29698507
31MP0005375_adipose_tissue_phenotype1.28614784
32MP0002075_abnormal_coat/hair_pigmentati1.25659829
33MP0005023_abnormal_wound_healing1.20519573
34MP0001756_abnormal_urination1.17923074
35MP0002909_abnormal_adrenal_gland1.12078919
36MP0003453_abnormal_keratinocyte_physiol1.05338799
37MP0003011_delayed_dark_adaptation1.02686469
38MP0000230_abnormal_systemic_arterial0.98084239
39MP0004272_abnormal_basement_membrane0.94703973
40MP0004947_skin_inflammation0.92000267
41MP0004085_abnormal_heartbeat0.88464617
42MP0005334_abnormal_fat_pad0.88381303
43MP0001765_abnormal_ion_homeostasis0.87532556
44MP0003566_abnormal_cell_adhesion0.86036330
45MP0001186_pigmentation_phenotype0.81046722
46MP0010386_abnormal_urinary_bladder0.76029256
47MP0003136_yellow_coat_color0.74213725
48MP0002557_abnormal_social/conspecific_i0.73937187
49MP0002128_abnormal_blood_circulation0.72564287
50MP0010352_gastrointestinal_tract_polyps0.72107299
51MP0000685_abnormal_immune_system0.72025110
52MP0003183_abnormal_peptide_metabolism0.69169326
53MP0004185_abnormal_adipocyte_glucose0.65780093
54MP0002972_abnormal_cardiac_muscle0.62401015
55MP0003385_abnormal_body_wall0.62246514
56MP0001915_intracranial_hemorrhage0.61338863
57MP0009780_abnormal_chondrocyte_physiolo0.61169337
58MP0003705_abnormal_hypodermis_morpholog0.60609002
59MP0000681_abnormal_thyroid_gland0.59922945
60MP0002086_abnormal_extraembryonic_tissu0.58088079
61MP0001340_abnormal_eyelid_morphology0.55084471
62MP0005452_abnormal_adipose_tissue0.55081547
63MP0003795_abnormal_bone_structure0.54332416
64MP0004782_abnormal_surfactant_physiolog0.53615288
65MP0001119_abnormal_female_reproductive0.52736398
66MP0005319_abnormal_enzyme/_coenzyme0.52192983
67MP0000367_abnormal_coat/_hair0.51863857
68MP0005409_darkened_coat_color0.49882061
69MP0002210_abnormal_sex_determination0.49377429
70MP0000383_abnormal_hair_follicle0.48464553
71MP0003699_abnormal_female_reproductive0.48096886
72MP0003252_abnormal_bile_duct0.47364538
73MP0003122_maternal_imprinting0.46081789
74MP0002295_abnormal_pulmonary_circulatio0.45991547
75MP0005636_abnormal_mineral_homeostasis0.43995259
76MP0005083_abnormal_biliary_tract0.43883808
77MP0003953_abnormal_hormone_level0.43084009
78MP0001958_emphysema0.42758611
79MP0003567_abnormal_fetal_cardiomyocyte0.40552584
80MP0003091_abnormal_cell_migration0.39965830
81MP0004145_abnormal_muscle_electrophysio0.39921754
82MP0008438_abnormal_cutaneous_collagen0.37735095
83MP0005187_abnormal_penis_morphology0.37109455
84MP0005085_abnormal_gallbladder_physiolo0.36305018
85MP0002138_abnormal_hepatobiliary_system0.36116068
86MP0003828_pulmonary_edema0.35948038
87MP0000427_abnormal_hair_cycle0.35849167
88MP0000266_abnormal_heart_morphology0.35411912
89MP0000759_abnormal_skeletal_muscle0.35085359
90MP0001544_abnormal_cardiovascular_syste0.34821680
91MP0005385_cardiovascular_system_phenoty0.34821680
92MP0000598_abnormal_liver_morphology0.34071938
93MP0010678_abnormal_skin_adnexa0.34011856
94MP0005397_hematopoietic_system_phenotyp0.33370773
95MP0001545_abnormal_hematopoietic_system0.33370773
96MP0004381_abnormal_hair_follicle0.32235889
97MP0005076_abnormal_cell_differentiation0.32230349
98MP0002136_abnormal_kidney_physiology0.31632311
99MP0005595_abnormal_vascular_smooth0.29824713
100MP0005666_abnormal_adipose_tissue0.28403246

Predicted human phenotypes

RankGene SetZ-score
1Capillary hemangiomas (HP:0005306)9.44697407
2Hypergonadotropic hypogonadism (HP:0000815)8.68486794
3Decreased number of large peripheral myelinated nerve fibers (HP:0003387)8.18877027
4Upper limb muscle weakness (HP:0003484)8.16193467
5Nonimmune hydrops fetalis (HP:0001790)6.63230794
6Abnormal pupillary function (HP:0007686)6.56286702
7Muscle fibrillation (HP:0010546)6.55164702
8Tongue fasciculations (HP:0001308)6.35923057
9Abnormal auditory evoked potentials (HP:0006958)6.16078119
10Accelerated skeletal maturation (HP:0005616)6.04641286
11Female pseudohermaphroditism (HP:0010458)5.27113462
12Anosmia (HP:0000458)4.98472502
13Back pain (HP:0003418)4.45507125
14Abnormality of the ischium (HP:0003174)4.23557690
15Lower limb asymmetry (HP:0100559)3.93372620
16Gynecomastia (HP:0000771)3.89386225
17Basal cell carcinoma (HP:0002671)3.53664668
18Pseudobulbar signs (HP:0002200)3.52411085
19Bilateral microphthalmos (HP:0007633)3.51213191
20Hypogonadotrophic hypogonadism (HP:0000044)3.49322942
21Wormian bones (HP:0002645)3.22759299
22Onion bulb formation (HP:0003383)3.22450174
23Abnormal pancreas size (HP:0012094)3.15753039
24Long palpebral fissure (HP:0000637)3.05155470
25Primary amenorrhea (HP:0000786)3.00698027
26Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.98618656
27Congenital ichthyosiform erythroderma (HP:0007431)2.98160658
28Long eyelashes (HP:0000527)2.93133527
29Areflexia of lower limbs (HP:0002522)2.91303681
30Bilateral sensorineural hearing impairment (HP:0008619)2.90162619
31Genu valgum (HP:0002857)2.88014955
32Delayed gross motor development (HP:0002194)2.79707074
33Difficulty walking (HP:0002355)2.79114229
34Abnormality of glycolipid metabolism (HP:0010969)2.74317351
35Abnormality of liposaccharide metabolism (HP:0010968)2.74317351
36Abnormality of glycosphingolipid metabolism (HP:0004343)2.74317351
37Sex reversal (HP:0012245)2.73144990
38Abnormal sex determination (HP:0012244)2.73144990
39Venous insufficiency (HP:0005293)2.72887923
40Disproportionate tall stature (HP:0001519)2.69392111
41Testicular neoplasm (HP:0010788)2.62062499
42Aplasia/Hypoplasia of the tibia (HP:0005772)2.53982486
43Decreased motor nerve conduction velocity (HP:0003431)2.52162373
44Peripheral demyelination (HP:0011096)2.48280220
45Aortic aneurysm (HP:0004942)2.47039929
46Flat cornea (HP:0007720)2.43700852
47Abnormality of the aortic arch (HP:0012303)2.43591220
48Bicornuate uterus (HP:0000813)2.43448692
49Cardiovascular calcification (HP:0011915)2.43180562
50Fragile skin (HP:0001030)2.40577521
51Polycythemia (HP:0001901)2.39360819
52Hyperaldosteronism (HP:0000859)2.35589685
53Hypoplastic nipples (HP:0002557)2.35369511
54Short tibia (HP:0005736)2.29857902
55Abnormality of the pupil (HP:0000615)2.24521929
56Aplasia of the musculature (HP:0100854)2.23322599
57Hematochezia (HP:0002573)2.20823713
58Venous abnormality (HP:0002624)2.19369359
59Morphological abnormality of the middle ear (HP:0008609)2.15445453
60Asymmetric growth (HP:0100555)2.14442495
61Arteriovenous malformation (HP:0100026)2.09089706
62Distal lower limb muscle weakness (HP:0009053)2.07649187
63Hyporeflexia of lower limbs (HP:0002600)2.04556997
64Renal salt wasting (HP:0000127)2.02043250
65Spontaneous hematomas (HP:0007420)2.00568542
66Decreased circulating renin level (HP:0003351)2.00002936
67Hypoplasia of the iris (HP:0007676)1.99485588
68Hypohidrosis (HP:0000966)1.95138051
69Mutism (HP:0002300)1.92940400
70Blue sclerae (HP:0000592)1.90635042
71Hypoplasia of the uterus (HP:0000013)1.89924974
72Fasciculations (HP:0002380)1.84066993
73Breast hypoplasia (HP:0003187)1.82117853
74Vascular calcification (HP:0004934)1.78088140
75Anophthalmia (HP:0000528)1.76711131
76Annular pancreas (HP:0001734)1.75684704
77Sparse lateral eyebrow (HP:0005338)1.75459410
78Overgrowth (HP:0001548)1.74561682
79Myotonia (HP:0002486)1.74329469
80Osteolytic defects of the hand bones (HP:0009699)1.73342025
81Osteolytic defects of the phalanges of the hand (HP:0009771)1.73342025
82Severe Myopia (HP:0011003)1.72809376
83Confusion (HP:0001289)1.69884669
84Ulnar deviation of finger (HP:0009465)1.67568022
85Knee flexion contracture (HP:0006380)1.66562619
86Abnormal autonomic nervous system physiology (HP:0012332)1.63764088
87Hoarse voice (HP:0001609)1.62809040
88Ectopic kidney (HP:0000086)1.61818908
89Neonatal hypoglycemia (HP:0001998)1.60636574
90Protruding ear (HP:0000411)1.60622645
91Cerebral aneurysm (HP:0004944)1.58808306
92Wide intermamillary distance (HP:0006610)1.55953968
93Hyperpituitarism (HP:0010514)1.52179920
94Elbow flexion contracture (HP:0002987)1.51151430
95Abnormality of incisor morphology (HP:0011063)1.49352072
96Tarsal synostosis (HP:0008368)1.49308060
97Abnormality of the axillary hair (HP:0100134)1.49209723
98Abnormality of secondary sexual hair (HP:0009888)1.49209723
99Lymphedema (HP:0001004)1.49157393
100Kyphoscoliosis (HP:0002751)1.47945402

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR9.91244306
2PDGFRA6.33899647
3AKT35.85923751
4DAPK24.53512721
5BLK2.70309864
6PDGFRB2.57482857
7MST42.25449328
8FRK2.23810467
9ICK2.16690526
10TIE11.82566790
11NME11.81752299
12NEK91.67553400
13DAPK11.62300488
14PKN11.58502589
15ERBB41.34698885
16LATS11.20068043
17MAP3K71.13981335
18DAPK31.08913613
19EPHA21.08563490
20MYLK1.08025891
21RPS6KA21.05184250
22INSRR1.03360694
23INSR1.02831888
24SRC0.99650727
25PDPK10.97846723
26TRPM70.96583927
27MET0.95858603
28RIPK10.94664170
29EGFR0.87744582
30STK380.84462530
31MAPK130.84221840
32MAP3K90.76939902
33RPS6KA60.74098295
34RPS6KC10.65738598
35RPS6KL10.65738598
36STK100.63512591
37TGFBR20.62650831
38PINK10.59284807
39AKT20.57730347
40TYK20.57444217
41MST1R0.56378715
42PRKD20.54656910
43MAP3K120.50978545
44MARK20.50753229
45PTK60.48679248
46MAP2K10.48619908
47PRKCZ0.47996152
48MAPK110.47615939
49PDK10.44859993
50JAK20.44629323
51PRKCQ0.43953654
52PTK2B0.42796060
53PRKD10.41657760
54PRKAA20.39332857
55MTOR0.38276414
56ADRBK10.37943578
57ERBB30.37160981
58PRKCE0.35730780
59AURKB0.34892226
60CDC42BPA0.34216433
61MAPK40.33610685
62PRKG20.32141231
63ROCK10.31735240
64BRD40.30853857
65PIK3CA0.29489617
66PRKCA0.29451286
67YES10.28806281
68MELK0.28689641
69SGK2230.28148709
70SGK4940.28148709
71FER0.27917941
72STK30.27085369
73KIT0.26449163
74PIK3CG0.26309275
75LYN0.24544736
76LCK0.24196982
77SGK10.21801953
78PRKAA10.21335581
79HCK0.19713252
80CAMK2G0.17513350
81MAPK10.17391744
82ACVR1B0.17297505
83FES0.16760481
84ERBB20.16009652
85EPHB20.15379474
86MAPKAPK30.14358954
87CAMK40.13557027
88PAK20.13268574
89STK38L0.11991990
90PRKCB0.11754490
91PTK20.11389233
92TBK10.09564084
93ADRBK20.09046084
94ROCK20.08845856
95STK240.08612977
96RPS6KA10.08447348
97BMPR20.07994276
98MAPK30.07534707
99CAMK10.07532544
100PRKCI0.07295388

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049139.14275708
2Steroid hormone biosynthesis_Homo sapiens_hsa001408.10460399
3Jak-STAT signaling pathway_Homo sapiens_hsa046303.99478724
4Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.27814961
5Aldosterone synthesis and secretion_Homo sapiens_hsa049252.26422815
6Sphingolipid metabolism_Homo sapiens_hsa006002.07296528
7Folate biosynthesis_Homo sapiens_hsa007902.03833433
8PI3K-Akt signaling pathway_Homo sapiens_hsa041512.02604445
9N-Glycan biosynthesis_Homo sapiens_hsa005101.84211283
10Renin-angiotensin system_Homo sapiens_hsa046141.74360564
11Mineral absorption_Homo sapiens_hsa049781.71783364
12Histidine metabolism_Homo sapiens_hsa003401.51909262
13Salivary secretion_Homo sapiens_hsa049701.32909188
14Inositol phosphate metabolism_Homo sapiens_hsa005621.32422843
15Tryptophan metabolism_Homo sapiens_hsa003801.24315145
16Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20924478
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15415886
18ECM-receptor interaction_Homo sapiens_hsa045121.15252270
19Vitamin digestion and absorption_Homo sapiens_hsa049771.13811349
20Focal adhesion_Homo sapiens_hsa045101.07000582
21Ras signaling pathway_Homo sapiens_hsa040141.05803195
22Axon guidance_Homo sapiens_hsa043601.04312032
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99696426
24Dorso-ventral axis formation_Homo sapiens_hsa043200.96226008
25Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95958727
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95264564
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94919387
28Prolactin signaling pathway_Homo sapiens_hsa049170.92490763
29Sphingolipid signaling pathway_Homo sapiens_hsa040710.79621313
30Renal cell carcinoma_Homo sapiens_hsa052110.72645542
31Rap1 signaling pathway_Homo sapiens_hsa040150.68720229
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67720620
33Glycosaminoglycan degradation_Homo sapiens_hsa005310.66933847
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62557076
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57024465
36Thyroid hormone synthesis_Homo sapiens_hsa049180.56207783
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53194075
38Malaria_Homo sapiens_hsa051440.52260540
39Tight junction_Homo sapiens_hsa045300.50139882
40Bladder cancer_Homo sapiens_hsa052190.47782008
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46192096
42ABC transporters_Homo sapiens_hsa020100.44950636
43HIF-1 signaling pathway_Homo sapiens_hsa040660.44051203
44Proteoglycans in cancer_Homo sapiens_hsa052050.43714443
45Fatty acid biosynthesis_Homo sapiens_hsa000610.43302521
46Endocytosis_Homo sapiens_hsa041440.43109974
47Adherens junction_Homo sapiens_hsa045200.41007994
48TGF-beta signaling pathway_Homo sapiens_hsa043500.40621307
49Small cell lung cancer_Homo sapiens_hsa052220.40323509
50Complement and coagulation cascades_Homo sapiens_hsa046100.39901804
51Platelet activation_Homo sapiens_hsa046110.37941345
52Insulin resistance_Homo sapiens_hsa049310.37667015
53Pathways in cancer_Homo sapiens_hsa052000.37179811
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35546339
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35033877
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34777406
57FoxO signaling pathway_Homo sapiens_hsa040680.34158595
58ErbB signaling pathway_Homo sapiens_hsa040120.33935599
59Type II diabetes mellitus_Homo sapiens_hsa049300.32764125
60Prostate cancer_Homo sapiens_hsa052150.32364681
61Olfactory transduction_Homo sapiens_hsa047400.30254919
62Hippo signaling pathway_Homo sapiens_hsa043900.30122578
63Autoimmune thyroid disease_Homo sapiens_hsa053200.29252295
64Nicotine addiction_Homo sapiens_hsa050330.28392255
65Other glycan degradation_Homo sapiens_hsa005110.28185609
66Gastric acid secretion_Homo sapiens_hsa049710.28113027
67Arginine and proline metabolism_Homo sapiens_hsa003300.28108283
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28028672
69GnRH signaling pathway_Homo sapiens_hsa049120.28001900
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.27635425
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27390864
72Circadian rhythm_Homo sapiens_hsa047100.26890703
73Metabolic pathways_Homo sapiens_hsa011000.26302584
74MAPK signaling pathway_Homo sapiens_hsa040100.25058290
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24190259
76Amoebiasis_Homo sapiens_hsa051460.24184231
77Chronic myeloid leukemia_Homo sapiens_hsa052200.23848767
78Lysosome_Homo sapiens_hsa041420.22616923
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.20977769
80Morphine addiction_Homo sapiens_hsa050320.19543087
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19005542
82Regulation of autophagy_Homo sapiens_hsa041400.18807604
83Acute myeloid leukemia_Homo sapiens_hsa052210.17553530
84GABAergic synapse_Homo sapiens_hsa047270.17327558
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17198466
86Linoleic acid metabolism_Homo sapiens_hsa005910.16910948
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.16245750
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.15742076
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15405779
90Bile secretion_Homo sapiens_hsa049760.15031503
91Melanoma_Homo sapiens_hsa052180.14452619
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.14305647
93Estrogen signaling pathway_Homo sapiens_hsa049150.13581131
94Choline metabolism in cancer_Homo sapiens_hsa052310.13388885
95Protein digestion and absorption_Homo sapiens_hsa049740.12567050
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.11331094
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.11316157
98Toxoplasmosis_Homo sapiens_hsa051450.10888105
99Cholinergic synapse_Homo sapiens_hsa047250.10616240
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.10572565

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