PSG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane depolarization during cardiac muscle cell action potential (GO:0086012)8.35243586
2membrane repolarization during cardiac muscle cell action potential (GO:0086013)8.05621134
3membrane repolarization during action potential (GO:0086011)7.31883120
4vitamin A metabolic process (GO:0006776)6.90927043
5behavioral response to nicotine (GO:0035095)6.60676771
6membrane repolarization (GO:0086009)5.74367474
7parturition (GO:0007567)5.60901260
8negative regulation of DNA-dependent DNA replication (GO:2000104)5.24545293
9positive regulation of synapse maturation (GO:0090129)5.19257767
10cellular response to electrical stimulus (GO:0071257)5.03937793
11regulation of membrane repolarization (GO:0060306)5.01121321
12cerebellar Purkinje cell differentiation (GO:0021702)4.95050487
13cell proliferation in forebrain (GO:0021846)4.80580256
14regulation of synapse maturation (GO:0090128)4.50080446
15serotonin metabolic process (GO:0042428)4.33698455
16mesenchymal cell differentiation involved in renal system development (GO:2001012)4.32065787
17mesenchymal cell differentiation involved in kidney development (GO:0072161)4.32065787
18negative regulation of response to food (GO:0032096)4.07251081
19negative regulation of appetite (GO:0032099)4.07251081
20negative regulation of transcription regulatory region DNA binding (GO:2000678)4.05691034
21spinal cord development (GO:0021510)4.04894354
22cellular potassium ion homeostasis (GO:0030007)4.01863914
23dendritic spine morphogenesis (GO:0060997)3.97921202
24forebrain neuron differentiation (GO:0021879)3.90997378
25regulation of potassium ion transmembrane transport (GO:1901379)3.83615358
26spinal cord association neuron differentiation (GO:0021527)3.82809803
27regulation of heart rate by cardiac conduction (GO:0086091)3.74215766
28primary amino compound metabolic process (GO:1901160)3.73346553
29regulation of female receptivity (GO:0045924)3.72136380
30DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.70911820
31embryonic retina morphogenesis in camera-type eye (GO:0060059)3.67045288
32interkinetic nuclear migration (GO:0022027)3.67039126
33regulation of potassium ion transmembrane transporter activity (GO:1901016)3.58818103
34cell differentiation in hindbrain (GO:0021533)3.55824656
35tooth mineralization (GO:0034505)3.50548904
36gamma-aminobutyric acid transport (GO:0015812)3.50190261
37positive regulation of RNA splicing (GO:0033120)3.48373523
38magnesium ion transport (GO:0015693)3.32128137
39cellular anion homeostasis (GO:0030002)3.32007429
40DNA damage response, signal transduction resulting in transcription (GO:0042772)3.28200042
41positive regulation of fatty acid beta-oxidation (GO:0032000)3.27133416
42behavioral defense response (GO:0002209)3.25392868
43behavioral fear response (GO:0001662)3.25392868
44membrane depolarization during action potential (GO:0086010)3.25361518
45multicellular organismal signaling (GO:0035637)3.20857700
46transmission of nerve impulse (GO:0019226)3.20775134
47regulation of skeletal muscle contraction (GO:0014819)3.18762067
48head development (GO:0060322)3.18748955
49fear response (GO:0042596)3.18723554
50regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.15659676
51fat-soluble vitamin catabolic process (GO:0042363)3.07933109
52vitamin catabolic process (GO:0009111)3.07933109
53female mating behavior (GO:0060180)3.07867604
54cardiac conduction (GO:0061337)3.05811145
55mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.04593335
56positive regulation of potassium ion transmembrane transport (GO:1901381)3.04551390
57locomotory exploration behavior (GO:0035641)3.02443246
58negative regulation of systemic arterial blood pressure (GO:0003085)2.99199022
59negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.98831825
60retinal ganglion cell axon guidance (GO:0031290)2.97246339
61response to electrical stimulus (GO:0051602)2.94821135
62sister chromatid cohesion (GO:0007062)2.91844904
63adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.90375624
64ovulation cycle (GO:0042698)2.83140564
65negative regulation of protein localization to cell surface (GO:2000009)2.81731172
66positive regulation of T cell apoptotic process (GO:0070234)2.80577747
67positive regulation of fatty acid oxidation (GO:0046321)2.80462569
68postsynaptic membrane organization (GO:0001941)2.79846398
69central nervous system myelination (GO:0022010)2.77205075
70axon ensheathment in central nervous system (GO:0032291)2.77205075
71snRNA transcription (GO:0009301)2.76960667
72regulation of mesoderm development (GO:2000380)2.75853257
73axonal fasciculation (GO:0007413)2.75578293
74nonmotile primary cilium assembly (GO:0035058)2.75391926
75calcium ion import (GO:0070509)2.75174909
76protein localization to synapse (GO:0035418)2.75164246
77positive regulation of cardiac muscle cell differentiation (GO:2000727)2.73804915
78regulation of potassium ion transport (GO:0043266)2.73793994
79uterus development (GO:0060065)2.73272700
80telencephalon development (GO:0021537)2.72998443
81pyrimidine nucleobase catabolic process (GO:0006208)2.71888037
82camera-type eye morphogenesis (GO:0048593)2.71881365
83regulation of response to food (GO:0032095)2.68874687
84phosphate ion homeostasis (GO:0055062)2.68397875
85trivalent inorganic anion homeostasis (GO:0072506)2.68397875
86regulation of protein heterodimerization activity (GO:0043497)2.66910610
87glomerulus development (GO:0032835)2.66482859
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.65350891
89substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.64627466
90substrate-independent telencephalic tangential migration (GO:0021826)2.64627466
91positive regulation of gastrulation (GO:2000543)2.64483191
92middle ear morphogenesis (GO:0042474)2.63834640
93negative regulation of neurotransmitter secretion (GO:0046929)2.63613165
94potassium ion import (GO:0010107)2.62938022
95negative regulation of potassium ion transmembrane transport (GO:1901380)2.61133734
96positive regulation of protein homodimerization activity (GO:0090073)2.60739658
97tachykinin receptor signaling pathway (GO:0007217)2.58141755
98neuron maturation (GO:0042551)2.57737342
99cardiovascular system development (GO:0072358)2.56180906
100regulation of DNA endoreduplication (GO:0032875)10.5671008

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.62125781
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00442777
3EZH2_27304074_Chip-Seq_ESCs_Mouse2.93267831
4JARID2_20075857_ChIP-Seq_MESCs_Mouse2.88066339
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.78224078
6CBX2_27304074_Chip-Seq_ESCs_Mouse2.66452921
7RNF2_27304074_Chip-Seq_ESCs_Mouse2.65094757
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61222047
9EZH2_27294783_Chip-Seq_ESCs_Mouse2.55791563
10SUZ12_27294783_Chip-Seq_ESCs_Mouse2.55170759
11REST_21632747_ChIP-Seq_MESCs_Mouse2.51459729
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.49144064
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41548180
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41548180
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.39900780
16IRF1_19129219_ChIP-ChIP_H3396_Human2.39674143
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32434693
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29810540
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27157709
20PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.16285962
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09745291
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04759955
23RNF2_27304074_Chip-Seq_NSC_Mouse2.02600060
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99186153
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97234793
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.94887558
27CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.91711347
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.80153117
29VDR_22108803_ChIP-Seq_LS180_Human1.78445322
30RING1B_27294783_Chip-Seq_ESCs_Mouse1.77888447
31TP53_20018659_ChIP-ChIP_R1E_Mouse1.77530835
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72986922
33DROSHA_22980978_ChIP-Seq_HELA_Human1.69753203
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.65949984
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64861875
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64397349
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61555271
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56584300
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53575347
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.53412731
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50369842
42RING1B_27294783_Chip-Seq_NPCs_Mouse1.47540275
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47394708
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.46596656
45RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.43657617
46GBX2_23144817_ChIP-Seq_PC3_Human1.43623469
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34678935
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28987511
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28246912
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28246912
51TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23373921
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23051143
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21141797
54CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18398417
55IGF1R_20145208_ChIP-Seq_DFB_Human1.17639702
56RXR_22108803_ChIP-Seq_LS180_Human1.16791324
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16665690
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16376951
59* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14815167
60TAF15_26573619_Chip-Seq_HEK293_Human1.12224266
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.10793836
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10788726
63KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06379746
64RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06316701
65SMAD4_21799915_ChIP-Seq_A2780_Human1.05713424
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.04941889
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.04862289
68STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04686605
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04118078
70P300_19829295_ChIP-Seq_ESCs_Human1.02887871
71FUS_26573619_Chip-Seq_HEK293_Human1.02852537
72* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02728930
73AHR_22903824_ChIP-Seq_MCF-7_Human1.02128877
74AR_19668381_ChIP-Seq_PC3_Human1.02096757
75MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01525715
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00430933
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00169555
78OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00151877
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99621538
80AR_21572438_ChIP-Seq_LNCaP_Human0.99041191
81WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97113070
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95187909
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94788000
84ZNF274_21170338_ChIP-Seq_K562_Hela0.94424402
85SOX2_21211035_ChIP-Seq_LN229_Gbm0.93947152
86LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92870665
87TP63_19390658_ChIP-ChIP_HaCaT_Human0.92734760
88STAT3_23295773_ChIP-Seq_U87_Human0.90910223
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.90365752
90CTCF_27219007_Chip-Seq_Bcells_Human0.89456758
91SMAD3_21741376_ChIP-Seq_ESCs_Human0.88678827
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88654319
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88591017
94TAL1_26923725_Chip-Seq_HPCs_Mouse0.87857065
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.87115751
96EWS_26573619_Chip-Seq_HEK293_Human0.85645266
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85242526
98* TCF4_23295773_ChIP-Seq_U87_Human0.85236984
99KDM2B_26808549_Chip-Seq_K562_Human0.84433301
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.84113676

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003879_abnormal_hair_cell3.27020750
2MP0001485_abnormal_pinna_reflex3.08170458
3MP0006292_abnormal_olfactory_placode3.07497606
4MP0000569_abnormal_digit_pigmentation2.95855625
5MP0006276_abnormal_autonomic_nervous2.84219981
6MP0003646_muscle_fatigue2.73670700
7MP0001440_abnormal_grooming_behavior2.72305031
8MP0004130_abnormal_muscle_cell2.61612561
9MP0002160_abnormal_reproductive_system2.59209643
10MP0005423_abnormal_somatic_nervous2.58240483
11MP0002653_abnormal_ependyma_morphology2.57545113
12MP0000778_abnormal_nervous_system2.35216204
13MP0002837_dystrophic_cardiac_calcinosis2.31209835
14MP0003123_paternal_imprinting2.21884438
15MP0003787_abnormal_imprinting2.21165356
16MP0004145_abnormal_muscle_electrophysio2.13920932
17MP0004019_abnormal_vitamin_homeostasis1.93351099
18MP0009379_abnormal_foot_pigmentation1.91483151
19MP0002163_abnormal_gland_morphology1.87249807
20MP0004742_abnormal_vestibular_system1.85817040
21MP0002184_abnormal_innervation1.81416451
22MP0009384_cardiac_valve_regurgitation1.80061909
23MP0002272_abnormal_nervous_system1.71487523
24MP0009745_abnormal_behavioral_response1.69847802
25MP0003635_abnormal_synaptic_transmissio1.67113159
26MP0005389_reproductive_system_phenotype1.62813342
27MP0004885_abnormal_endolymph1.62399850
28MP0003890_abnormal_embryonic-extraembry1.61331291
29MP0003942_abnormal_urinary_system1.57422106
30MP0000955_abnormal_spinal_cord1.56211172
31MP0004185_abnormal_adipocyte_glucose1.55837870
32MP0002063_abnormal_learning/memory/cond1.54603634
33MP0002733_abnormal_thermal_nociception1.53226794
34MP0008775_abnormal_heart_ventricle1.53180906
35MP0004859_abnormal_synaptic_plasticity1.51734383
36MP0000049_abnormal_middle_ear1.49233215
37MP0001188_hyperpigmentation1.45992769
38MP0002909_abnormal_adrenal_gland1.45238002
39MP0002557_abnormal_social/conspecific_i1.41493646
40MP0000026_abnormal_inner_ear1.38800621
41MP0000631_abnormal_neuroendocrine_gland1.37965573
42MP0002064_seizures1.36838531
43MP0003880_abnormal_central_pattern1.36571393
44MP0005551_abnormal_eye_electrophysiolog1.36455490
45MP0001542_abnormal_bone_strength1.35464202
46MP0002882_abnormal_neuron_morphology1.34243443
47MP0004134_abnormal_chest_morphology1.33600621
48MP0001970_abnormal_pain_threshold1.32645241
49MP0002752_abnormal_somatic_nervous1.32567487
50MP0004142_abnormal_muscle_tone1.30539904
51MP0003011_delayed_dark_adaptation1.30425678
52MP0002572_abnormal_emotion/affect_behav1.30217652
53MP0001486_abnormal_startle_reflex1.26500435
54MP0002090_abnormal_vision1.25577481
55MP0004270_analgesia1.21924725
56MP0009046_muscle_twitch1.20962478
57MP0008789_abnormal_olfactory_epithelium1.19002487
58MP0002638_abnormal_pupillary_reflex1.18695547
59MP0002938_white_spotting1.15258704
60MP0001963_abnormal_hearing_physiology1.14896126
61MP0004085_abnormal_heartbeat1.14772162
62MP0002928_abnormal_bile_duct1.12927774
63MP0004215_abnormal_myocardial_fiber1.12418830
64MP0002876_abnormal_thyroid_physiology1.10406469
65MP0000230_abnormal_systemic_arterial1.09743129
66MP0002734_abnormal_mechanical_nocicepti1.07166861
67MP0002089_abnormal_postnatal_growth/wei1.06009105
68MP0003938_abnormal_ear_development1.04410083
69MP0002067_abnormal_sensory_capabilities1.03736722
70MP0001986_abnormal_taste_sensitivity1.03420255
71MP0009250_abnormal_appendicular_skeleto0.99899370
72MP0000534_abnormal_ureter_morphology0.98809424
73MP0001984_abnormal_olfaction0.98756893
74MP0005379_endocrine/exocrine_gland_phen0.98235032
75MP0005083_abnormal_biliary_tract0.98176983
76MP0005195_abnormal_posterior_eye0.97694643
77MP0002152_abnormal_brain_morphology0.97071870
78MP0000427_abnormal_hair_cycle0.96685939
79MP0005499_abnormal_olfactory_system0.96270129
80MP0005394_taste/olfaction_phenotype0.96270129
81MP0003121_genomic_imprinting0.96246769
82MP0005257_abnormal_intraocular_pressure0.94711817
83MP0003136_yellow_coat_color0.91881084
84MP0004133_heterotaxia0.91077373
85MP0005174_abnormal_tail_pigmentation0.90986460
86MP0002229_neurodegeneration0.90263123
87MP0009115_abnormal_fat_cell0.89608280
88MP0008872_abnormal_physiological_respon0.87899493
89MP0003119_abnormal_digestive_system0.86516153
90MP0003861_abnormal_nervous_system0.86332717
91MP0004924_abnormal_behavior0.84778316
92MP0005386_behavior/neurological_phenoty0.84778316
93MP0001919_abnormal_reproductive_system0.84673242
94MP0001502_abnormal_circadian_rhythm0.83821487
95MP0008569_lethality_at_weaning0.83750967
96MP0000566_synostosis0.83035642
97MP0003385_abnormal_body_wall0.82933453
98MP0003137_abnormal_impulse_conducting0.80189679
99MP0005448_abnormal_energy_balance0.79284470
100MP0004811_abnormal_neuron_physiology0.77673837

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)5.66138653
2Metabolic alkalosis (HP:0200114)4.51134464
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.96498432
4Short 4th metacarpal (HP:0010044)3.96498432
5Progressive cerebellar ataxia (HP:0002073)3.83417292
6Abnormal pancreas size (HP:0012094)3.81351940
7Oligodontia (HP:0000677)3.66091407
8Abolished electroretinogram (ERG) (HP:0000550)3.59357536
9Decreased electroretinogram (ERG) amplitude (HP:0000654)3.59230984
10Nephronophthisis (HP:0000090)3.52429084
11Abnormality of the right ventricle (HP:0001707)3.47539842
12Osteomalacia (HP:0002749)3.45106918
13Abnormality of the 4th metacarpal (HP:0010012)3.27454463
14Genetic anticipation (HP:0003743)3.14141822
15Short femoral neck (HP:0100864)3.12681921
16Abnormality of the renal collecting system (HP:0004742)3.04882896
17Megalencephaly (HP:0001355)3.03003489
18Patent foramen ovale (HP:0001655)3.02781685
19Abnormality of renin-angiotensin system (HP:0000847)3.01706206
20Fibular hypoplasia (HP:0003038)2.98162612
21Abnormality of the renal medulla (HP:0100957)2.96202560
22Chronic hepatic failure (HP:0100626)2.95850995
23Clumsiness (HP:0002312)2.95544255
24Abnormality of midbrain morphology (HP:0002418)2.84170207
25Molar tooth sign on MRI (HP:0002419)2.84170207
26Hepatoblastoma (HP:0002884)2.82188654
27Diastasis recti (HP:0001540)2.80831030
28Pancreatic fibrosis (HP:0100732)2.77400253
29Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.69065945
30Stenosis of the external auditory canal (HP:0000402)2.68287119
31Adrenal hypoplasia (HP:0000835)2.65343627
32Aplasia/Hypoplasia of the fibula (HP:0006492)2.64069033
33Cerebral palsy (HP:0100021)2.63517112
34Aplasia involving bones of the upper limbs (HP:0009823)2.62408187
35Aplasia of the phalanges of the hand (HP:0009802)2.62408187
36Aplasia involving bones of the extremities (HP:0009825)2.62408187
37Cortical visual impairment (HP:0100704)2.60106158
38Fibular aplasia (HP:0002990)2.56720071
39Neonatal hypoglycemia (HP:0001998)2.56010179
40Epileptic encephalopathy (HP:0200134)2.54325405
41Hypoplasia of the ulna (HP:0003022)2.50396932
42Septo-optic dysplasia (HP:0100842)2.43997979
43True hermaphroditism (HP:0010459)2.42699256
44Periauricular skin pits (HP:0100277)2.42378705
45Preauricular pit (HP:0004467)2.42378705
46Myokymia (HP:0002411)2.41090375
47Abnormality of the phalanges of the 2nd finger (HP:0009541)2.39248312
48Neoplasm of the adrenal cortex (HP:0100641)2.39236618
49Tubular atrophy (HP:0000092)2.35121441
50Medial flaring of the eyebrow (HP:0010747)2.34674244
51Enlarged kidneys (HP:0000105)2.26287566
52Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.24677360
53Concave nail (HP:0001598)2.24611027
54Broad-based gait (HP:0002136)2.22680441
55Mesomelia (HP:0003027)2.21631873
56Abnormality of the 2nd finger (HP:0004100)2.18035873
57Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.16254043
58Pancreatic cysts (HP:0001737)2.16220956
59Abnormality of the middle phalanges of the toes (HP:0010183)2.15029996
60Gait imbalance (HP:0002141)2.14729469
61Abnormality of the phalanges of the 5th finger (HP:0004213)2.12578098
62Agitation (HP:0000713)2.12541538
63Persistence of primary teeth (HP:0006335)2.12109327
64Abnormality of cochlea (HP:0000375)2.10784156
65Lip pit (HP:0100267)2.08738729
66Metaphyseal dysplasia (HP:0100255)2.07996795
67Duplicated collecting system (HP:0000081)2.07249587
68Abnormality of the nasal septum (HP:0000419)2.05614994
69Down-sloping shoulders (HP:0200021)1.99685398
70Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.98375219
71Hypoplasia of the uterus (HP:0000013)1.96459994
72Bony spicule pigmentary retinopathy (HP:0007737)1.95560702
73Aplasia/Hypoplasia of the hallux (HP:0008362)1.93223112
74Specific learning disability (HP:0001328)1.92897623
75Sclerocornea (HP:0000647)1.91245089
76Hypogonadotrophic hypogonadism (HP:0000044)1.90599663
77Drooling (HP:0002307)1.90541342
78Aplasia/hypoplasia of the femur (HP:0005613)1.89356141
79Abnormality of the dental root (HP:0006486)1.88891391
80Taurodontia (HP:0000679)1.88891391
81Abnormality of permanent molar morphology (HP:0011071)1.88891391
82Congenital primary aphakia (HP:0007707)1.88660984
83Aplasia/Hypoplasia of the ulna (HP:0006495)1.88306233
84Short hallux (HP:0010109)1.87982121
85Aplasia/Hypoplasia of the tibia (HP:0005772)1.87391509
86Hypoplasia of dental enamel (HP:0006297)1.86949188
87Anomalous pulmonary venous return (HP:0010772)1.86567086
88Generalized tonic-clonic seizures (HP:0002069)1.86538536
89Intellectual disability, moderate (HP:0002342)1.84574523
90Focal seizures (HP:0007359)1.84019099
91Morphological abnormality of the middle ear (HP:0008609)1.83421574
92Cystic liver disease (HP:0006706)1.81978727
93Bradycardia (HP:0001662)1.81282902
94Maternal diabetes (HP:0009800)1.79929710
95Abnormality of secondary sexual hair (HP:0009888)1.79363968
96Abnormality of the axillary hair (HP:0100134)1.79363968
97Shawl scrotum (HP:0000049)1.79249410
98Impaired vibration sensation in the lower limbs (HP:0002166)1.77723258
99Hypokalemia (HP:0002900)1.77553120
100Anencephaly (HP:0002323)1.75610718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK24.75161676
2MAP3K93.43619388
3FRK3.41319333
4NTRK32.90596028
5RPS6KA22.24902993
6ADRBK22.17422484
7CASK2.07934196
8NTRK22.06763759
9WNK42.05644936
10STK241.81776055
11SGK21.77308852
12TYRO31.74569996
13PRKCG1.73441543
14MARK11.73415234
15STK111.70921614
16SGK2231.63789624
17SGK4941.63789624
18TAF11.60745507
19MAP2K71.55547074
20ERBB21.54755423
21PKN11.53253895
22SIK11.51617154
23RPS6KA61.49159541
24GRK11.48107652
25TLK11.36282151
26PINK11.35034138
27RPS6KC11.34444757
28RPS6KL11.34444757
29SGK31.32881335
30MAP3K111.29859344
31MAP3K41.25243185
32WNK11.24617565
33EPHB21.20162064
34DYRK21.18768324
35MARK21.17258295
36PRKCH1.11023430
37FGFR21.10340404
38SGK11.08250246
39PAK31.04891304
40CAMKK11.03075811
41HIPK20.99936357
42TNIK0.97548656
43CAMK1D0.97144636
44CAMKK20.96483779
45CAMK1G0.95358458
46PRKCZ0.94962186
47BMPR1B0.92906910
48ADRBK10.91478333
49MAP2K40.90772661
50MAPK40.88615531
51CDK50.86671505
52PDGFRB0.86262517
53MAPK130.85878908
54ABL20.84633911
55PRKACA0.84327749
56MINK10.83759615
57DYRK1A0.83238862
58DAPK20.74464414
59ICK0.72421973
60MAPK70.72379639
61MAPK150.70442623
62DMPK0.66529258
63MKNK20.65664461
64STK380.65486090
65CAMK10.63919210
66PRKCE0.63827218
67AURKA0.63676111
68PIK3CA0.62271161
69PHKG10.61801015
70PHKG20.61801015
71TGFBR10.61342861
72CDC70.60753339
73STK390.58926766
74TAOK30.58038341
75ACVR1B0.57642227
76MAPKAPK50.57367193
77AKT30.56472474
78STK30.56383566
79MAPK120.55758771
80RPS6KA30.51138772
81PNCK0.50564645
82RPS6KA10.50090318
83PRKACG0.49490462
84BTK0.49301430
85CSNK1A10.48229334
86CAMK2A0.47376756
87PRKD20.47013943
88ARAF0.46833956
89DYRK30.46594223
90MARK30.46389501
91ITK0.44953877
92AKT10.44680756
93INSRR0.40933031
94PRKCA0.40442583
95RPS6KB10.40347672
96NUAK10.39215828
97PRKCQ0.37764669
98MAPK80.37578246
99PRKD30.36740312
100MAPK140.36353587

Predicted pathways (KEGG)

RankGene SetZ-score
1Glutamatergic synapse_Homo sapiens_hsa047242.86264827
2Nicotine addiction_Homo sapiens_hsa050332.85100547
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57131817
4GABAergic synapse_Homo sapiens_hsa047272.51892237
5Morphine addiction_Homo sapiens_hsa050322.50728010
6Circadian entrainment_Homo sapiens_hsa047132.48288593
7Vitamin digestion and absorption_Homo sapiens_hsa049772.40808306
8Cholinergic synapse_Homo sapiens_hsa047252.38867506
9Serotonergic synapse_Homo sapiens_hsa047262.31332390
10Dopaminergic synapse_Homo sapiens_hsa047282.15044619
11Cardiac muscle contraction_Homo sapiens_hsa042602.14515022
12Cocaine addiction_Homo sapiens_hsa050301.83860879
13Type II diabetes mellitus_Homo sapiens_hsa049301.79875516
14Insulin secretion_Homo sapiens_hsa049111.77798747
15Axon guidance_Homo sapiens_hsa043601.74321889
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66450391
17Retinol metabolism_Homo sapiens_hsa008301.64109962
18Renin secretion_Homo sapiens_hsa049241.62865658
19Oxytocin signaling pathway_Homo sapiens_hsa049211.60796264
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46836788
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.45997588
22Amphetamine addiction_Homo sapiens_hsa050311.42896443
23Phototransduction_Homo sapiens_hsa047441.36432110
24MAPK signaling pathway_Homo sapiens_hsa040101.35879678
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34451219
26Calcium signaling pathway_Homo sapiens_hsa040201.34270504
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31662100
28Hedgehog signaling pathway_Homo sapiens_hsa043401.26071868
29Sulfur relay system_Homo sapiens_hsa041221.25289148
30Gastric acid secretion_Homo sapiens_hsa049711.22212946
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21516988
32cAMP signaling pathway_Homo sapiens_hsa040241.17499984
33Basal cell carcinoma_Homo sapiens_hsa052171.17306142
34Dilated cardiomyopathy_Homo sapiens_hsa054141.16281333
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15187663
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.11804161
37Dorso-ventral axis formation_Homo sapiens_hsa043201.11637219
38Notch signaling pathway_Homo sapiens_hsa043301.09602992
39Protein export_Homo sapiens_hsa030601.08237855
40Taste transduction_Homo sapiens_hsa047421.07009087
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06585550
42Linoleic acid metabolism_Homo sapiens_hsa005911.05327901
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.03643439
44Long-term depression_Homo sapiens_hsa047301.02851705
45Ras signaling pathway_Homo sapiens_hsa040141.02662765
46Tryptophan metabolism_Homo sapiens_hsa003801.01809313
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01049285
48Oxidative phosphorylation_Homo sapiens_hsa001900.96243801
49Long-term potentiation_Homo sapiens_hsa047200.94420968
50Hippo signaling pathway_Homo sapiens_hsa043900.92169238
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91678060
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91203785
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90860742
54Ovarian steroidogenesis_Homo sapiens_hsa049130.90335691
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88893423
56Olfactory transduction_Homo sapiens_hsa047400.88560679
57Alzheimers disease_Homo sapiens_hsa050100.87794632
58Melanoma_Homo sapiens_hsa052180.87620780
59Synaptic vesicle cycle_Homo sapiens_hsa047210.87383449
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.82271287
61Collecting duct acid secretion_Homo sapiens_hsa049660.81787501
62Rap1 signaling pathway_Homo sapiens_hsa040150.79634479
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79234409
64Wnt signaling pathway_Homo sapiens_hsa043100.72099495
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.71670221
66GnRH signaling pathway_Homo sapiens_hsa049120.70095235
67Steroid biosynthesis_Homo sapiens_hsa001000.69037311
68Salivary secretion_Homo sapiens_hsa049700.68170604
69Gap junction_Homo sapiens_hsa045400.67182591
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66480694
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65886707
72Alcoholism_Homo sapiens_hsa050340.62048787
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.60502767
74Chemical carcinogenesis_Homo sapiens_hsa052040.59975506
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58526518
76Glycerolipid metabolism_Homo sapiens_hsa005610.58236397
77VEGF signaling pathway_Homo sapiens_hsa043700.58192727
78Ether lipid metabolism_Homo sapiens_hsa005650.57831234
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55488703
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.55086719
81Huntingtons disease_Homo sapiens_hsa050160.51979769
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.51320869
83Parkinsons disease_Homo sapiens_hsa050120.50815031
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50090928
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50082467
86Insulin resistance_Homo sapiens_hsa049310.48725611
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48574406
88Melanogenesis_Homo sapiens_hsa049160.47217806
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46287045
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45021354
91Circadian rhythm_Homo sapiens_hsa047100.44778075
92Histidine metabolism_Homo sapiens_hsa003400.44575086
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43472121
94Ribosome_Homo sapiens_hsa030100.42631237
95Tight junction_Homo sapiens_hsa045300.41842125
96PPAR signaling pathway_Homo sapiens_hsa033200.41119713
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40124494
98Peroxisome_Homo sapiens_hsa041460.38291541
99ErbB signaling pathway_Homo sapiens_hsa040120.38146386
100Basal transcription factors_Homo sapiens_hsa030220.36491357

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