PSG3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1androgen metabolic process (GO:0008209)9.79581108
2* multi-multicellular organism process (GO:0044706)9.64686955
3positive regulation of growth hormone secretion (GO:0060124)9.28282091
4* multi-organism reproductive process (GO:0044703)8.40535108
5glucocorticoid metabolic process (GO:0008211)7.91316092
6hormone biosynthetic process (GO:0042446)7.24557292
7regulation of growth hormone secretion (GO:0060123)6.61388774
8vitamin transmembrane transport (GO:0035461)6.48265775
9myoblast fusion (GO:0007520)6.32927422
10collecting duct development (GO:0072044)6.19723422
11JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)6.16600401
12response to gonadotropin (GO:0034698)6.13034055
13positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-6.07139400
14syncytium formation (GO:0006949)5.89963200
15syncytium formation by plasma membrane fusion (GO:0000768)5.62186886
16positive regulation of protein kinase C signaling (GO:0090037)5.37039371
17endocrine hormone secretion (GO:0060986)5.23266110
18negative regulation of activin receptor signaling pathway (GO:0032926)5.16843395
19lymphangiogenesis (GO:0001946)5.06685963
20sphingoid metabolic process (GO:0046519)4.95122899
21vascular endothelial growth factor signaling pathway (GO:0038084)4.73237192
22cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.55733121
23bone morphogenesis (GO:0060349)4.24748717
24positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.02374311
25lymph vessel development (GO:0001945)4.01470139
26T-helper 1 type immune response (GO:0042088)4.00291214
27estrogen biosynthetic process (GO:0006703)32.3116334
28regulation of interferon-gamma biosynthetic process (GO:0045072)3.97596827
29protein neddylation (GO:0045116)3.90502071
30myelin maintenance (GO:0043217)3.83047815
31parturition (GO:0007567)3.58115871
32vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.49125542
33cellular hormone metabolic process (GO:0034754)3.49050322
34L-alpha-amino acid transmembrane transport (GO:1902475)3.44780030
35sequestering of extracellular ligand from receptor (GO:0035581)3.37120699
36interkinetic nuclear migration (GO:0022027)3.33464359
37sprouting angiogenesis (GO:0002040)3.33009298
38regulation of endocrine process (GO:0044060)3.30423622
39JAK-STAT cascade (GO:0007259)3.22691642
40negative regulation of smooth muscle cell differentiation (GO:0051151)3.20290421
41eyelid development in camera-type eye (GO:0061029)3.14510422
42regulation of G0 to G1 transition (GO:0070316)3.14018634
43positive regulation of insulin receptor signaling pathway (GO:0046628)3.07778470
44iron ion import (GO:0097286)3.03621819
45keratinocyte development (GO:0003334)3.03601097
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.90523239
47steroid biosynthetic process (GO:0006694)2.79881818
48negative regulation of cell-matrix adhesion (GO:0001953)2.77374806
49progesterone metabolic process (GO:0042448)2.71333653
50basement membrane organization (GO:0071711)2.68588467
51transcytosis (GO:0045056)2.67731964
52ear development (GO:0043583)2.62229395
53polarized epithelial cell differentiation (GO:0030859)2.60221808
54mitotic cytokinesis (GO:0000281)2.55860387
55sphingosine metabolic process (GO:0006670)2.54688497
56C21-steroid hormone biosynthetic process (GO:0006700)2.51657169
57regulation of protein kinase C signaling (GO:0090036)2.43095841
58hormone metabolic process (GO:0042445)2.39071920
59positive regulation of alpha-beta T cell proliferation (GO:0046641)2.34775378
60cytoskeleton-dependent cytokinesis (GO:0061640)2.30074274
61cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.29775629
62ketone biosynthetic process (GO:0042181)2.29014831
63Sertoli cell development (GO:0060009)2.27869076
64regulation of ruffle assembly (GO:1900027)2.26804769
65regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.25728095
66diol metabolic process (GO:0034311)2.22263953
67protein targeting to Golgi (GO:0000042)2.22234630
68establishment of protein localization to Golgi (GO:0072600)2.18399066
69blood vessel morphogenesis (GO:0048514)2.14641595
70regulation of calcium ion-dependent exocytosis (GO:0017158)2.13504094
71response to phenylpropanoid (GO:0080184)2.13098323
72negative regulation of macrophage differentiation (GO:0045650)2.12831722
73retrograde transport, vesicle recycling within Golgi (GO:0000301)2.09952389
74regulation of activin receptor signaling pathway (GO:0032925)2.09102430
75regulation of T-helper 2 cell differentiation (GO:0045628)2.08125660
76response to inactivity (GO:0014854)2.04482211
77positive regulation of cellular response to insulin stimulus (GO:1900078)2.04353816
78female genitalia development (GO:0030540)2.01642794
79Leydig cell differentiation (GO:0033327)2.00606132
80response to follicle-stimulating hormone (GO:0032354)15.4437685
81regulation of gonadotropin secretion (GO:0032276)14.0650016
82estrogen metabolic process (GO:0008210)14.0027508
83glucocorticoid biosynthetic process (GO:0006704)13.4120633
84* female pregnancy (GO:0007565)13.3401183
85prostate gland growth (GO:0060736)13.0611507
86androgen biosynthetic process (GO:0006702)11.2661044
87extracellular negative regulation of signal transduction (GO:1900116)1.96968425
88extracellular regulation of signal transduction (GO:1900115)1.96968425
89regulation of clathrin-mediated endocytosis (GO:2000369)1.95982315
90insulin-like growth factor receptor signaling pathway (GO:0048009)1.95846009
91vitamin D metabolic process (GO:0042359)1.94818037
92lung vasculature development (GO:0060426)1.94771793
93thyroid hormone generation (GO:0006590)1.94741889
94regulation of alpha-beta T cell proliferation (GO:0046640)1.94162545
95negative regulation of Ras protein signal transduction (GO:0046580)1.94130780
96positive regulation of T cell cytokine production (GO:0002726)1.93331780
97import into cell (GO:0098657)1.91103089
98mating behavior (GO:0007617)1.90968102
99positive regulation of cartilage development (GO:0061036)1.90671122
100apical protein localization (GO:0045176)1.89122509

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19032775_ChIP-ChIP_M12_Human5.93673077
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.57743045
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.00885908
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.87101249
5AHR_22903824_ChIP-Seq_MCF-7_Human2.75066301
6* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.59565860
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.58996759
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.58215313
9* TRIM28_17542650_ChIP-ChIP_NTERA2_Human2.54540068
10TP53_18474530_ChIP-ChIP_U2OS_Human2.43789545
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.23188816
12ARNT_22903824_ChIP-Seq_MCF-7_Human2.22097684
13ZNF217_24962896_ChIP-Seq_MCF-7_Human2.16672737
14CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.11322605
15* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human11.1107571
16P63_26484246_Chip-Seq_KERATINOCYTES_Human1.91977050
17BRD4_25478319_ChIP-Seq_HGPS_Human1.90470773
18ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.83627503
19* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82230628
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.77174208
21* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.76388307
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75663817
23ZNF263_19887448_ChIP-Seq_K562_Human1.73681914
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.63296934
25SCL_19346495_ChIP-Seq_HPC-7_Human1.62542611
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.59622607
27ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56481395
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47086402
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45410271
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44978955
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44978955
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39555121
33ER_23166858_ChIP-Seq_MCF-7_Human1.39196988
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39089534
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.38831716
36AR_21572438_ChIP-Seq_LNCaP_Human1.34450519
37PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.32589299
38GATA3_24758297_ChIP-Seq_MCF-7_Human1.31011278
39RXR_22108803_ChIP-Seq_LS180_Human1.30654554
40VDR_24787735_ChIP-Seq_THP-1_Human1.30359835
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.30281143
42TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26176547
43TP63_23658742_ChIP-Seq_EP156T_Human1.23348444
44CJUN_26792858_Chip-Seq_BT549_Human1.21704321
45CBP_20019798_ChIP-Seq_JUKART_Human1.20671128
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20671128
47P300_19829295_ChIP-Seq_ESCs_Human1.17911288
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.16854927
49SMAD3_21741376_ChIP-Seq_HESCs_Human1.14628687
50KLF4_19829295_ChIP-Seq_ESCs_Human1.12200358
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10383051
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09777805
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09777805
54SOX2_20726797_ChIP-Seq_SW620_Human1.08243324
55FUS_26573619_Chip-Seq_HEK293_Human1.06674337
56EWS_26573619_Chip-Seq_HEK293_Human1.06475158
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05436946
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05271032
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04910087
60TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04588207
61TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04451967
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04404004
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03896982
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03568108
65ERG_20517297_ChIP-Seq_VCAP_Human1.01154783
66CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00779893
67RUNX2_22187159_ChIP-Seq_PCA_Human0.99445645
68ISL1_27105846_Chip-Seq_CPCs_Mouse0.98754639
69PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97688118
70JUN_21703547_ChIP-Seq_K562_Human0.97189349
71GATA1_19941826_ChIP-Seq_K562_Human0.96538725
72JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96167944
73FOXA2_19822575_ChIP-Seq_HepG2_Human0.95113996
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94913659
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93099700
76NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93067517
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93067517
78JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91888847
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91374943
80IGF1R_20145208_ChIP-Seq_DFB_Human0.90327789
81JARID2_20075857_ChIP-Seq_MESCs_Mouse0.89595330
82POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89554097
83AR_19668381_ChIP-Seq_PC3_Human0.89207182
84RNF2_27304074_Chip-Seq_ESCs_Mouse0.88562937
85* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88371176
86TAF15_26573619_Chip-Seq_HEK293_Human0.87685892
87TP63_22573176_ChIP-Seq_HFKS_Human0.85613205
88HTT_18923047_ChIP-ChIP_STHdh_Human0.84409637
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83462874
90UBF1/2_26484160_Chip-Seq_HMECs_Human0.83124673
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82585404
92GATA4_25053715_ChIP-Seq_YYC3_Human0.81190261
93MTF2_20144788_ChIP-Seq_MESCs_Mouse0.81121583
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79577355
95SMAD4_21741376_ChIP-Seq_HESCs_Human0.79200556
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.78690428
97CDX2_22108803_ChIP-Seq_LS180_Human0.77576308
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.77566967
99SOX2_21211035_ChIP-Seq_LN229_Gbm0.77272676
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.76915087

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology7.03302545
2MP0005379_endocrine/exocrine_gland_phen5.50272971
3MP0006276_abnormal_autonomic_nervous4.88790443
4MP0005647_abnormal_sex_gland3.85449151
5MP0010368_abnormal_lymphatic_system3.83223816
6MP0001919_abnormal_reproductive_system3.58803192
7MP0000013_abnormal_adipose_tissue3.09520280
8MP0003941_abnormal_skin_development2.58479996
9MP0003959_abnormal_lean_body2.52627451
10MP0001440_abnormal_grooming_behavior2.50467146
11MP0000003_abnormal_adipose_tissue2.43802167
12MP0004019_abnormal_vitamin_homeostasis2.27878797
13MP0006054_spinal_hemorrhage2.26674068
14MP0005389_reproductive_system_phenotype2.04522596
15MP0002876_abnormal_thyroid_physiology2.04431462
16MP0009697_abnormal_copulation11.7038364
17MP0009115_abnormal_fat_cell1.86862499
18MP0001666_abnormal_nutrient_absorption1.84455914
19MP0006138_congestive_heart_failure1.61487011
20MP0000613_abnormal_salivary_gland1.61165613
21MP0002653_abnormal_ependyma_morphology1.58084025
22MP0003936_abnormal_reproductive_system1.56751481
23MP0002971_abnormal_brown_adipose1.55635479
24MP0000639_abnormal_adrenal_gland1.52281852
25MP0000647_abnormal_sebaceous_gland1.40242498
26MP0001879_abnormal_lymphatic_vessel1.40014925
27MP0002998_abnormal_bone_remodeling1.37487472
28MP0010329_abnormal_lipoprotein_level1.37102238
29MP0009703_decreased_birth_body1.35790219
30MP0005375_adipose_tissue_phenotype1.32534893
31MP0002075_abnormal_coat/hair_pigmentati1.26063065
32MP0001756_abnormal_urination1.16940044
33MP0005023_abnormal_wound_healing1.16686016
34MP0003453_abnormal_keratinocyte_physiol1.16595189
35MP0002909_abnormal_adrenal_gland1.11802669
36MP0003950_abnormal_plasma_membrane1.03919623
37MP0004947_skin_inflammation0.99003276
38MP0005334_abnormal_fat_pad0.90080137
39MP0004085_abnormal_heartbeat0.88808476
40MP0000230_abnormal_systemic_arterial0.87450304
41MP0003566_abnormal_cell_adhesion0.87371380
42MP0001186_pigmentation_phenotype0.83585175
43MP0001765_abnormal_ion_homeostasis0.83379092
44MP0010352_gastrointestinal_tract_polyps0.78905503
45MP0002128_abnormal_blood_circulation0.76795804
46MP0004185_abnormal_adipocyte_glucose0.75990219
47MP0003136_yellow_coat_color0.73957434
48MP0001915_intracranial_hemorrhage0.73479146
49MP0004272_abnormal_basement_membrane0.72822414
50MP0002557_abnormal_social/conspecific_i0.72733279
51MP0000685_abnormal_immune_system0.70401183
52MP0002086_abnormal_extraembryonic_tissu0.68035105
53MP0002972_abnormal_cardiac_muscle0.66950373
54MP0003705_abnormal_hypodermis_morpholog0.66350818
55MP0003385_abnormal_body_wall0.61470552
56MP0009780_abnormal_chondrocyte_physiolo0.60462244
57MP0005319_abnormal_enzyme/_coenzyme0.59689481
58MP0003795_abnormal_bone_structure0.59500528
59MP0005409_darkened_coat_color0.58979153
60MP0003122_maternal_imprinting0.58873709
61MP0000681_abnormal_thyroid_gland0.58702712
62MP0001340_abnormal_eyelid_morphology0.58439780
63MP0003567_abnormal_fetal_cardiomyocyte0.55031179
64MP0005452_abnormal_adipose_tissue0.54343072
65MP0004782_abnormal_surfactant_physiolog0.51668804
66MP0003183_abnormal_peptide_metabolism0.50428324
67MP0000367_abnormal_coat/_hair0.50250696
68MP0000383_abnormal_hair_follicle0.50120121
69MP0001119_abnormal_female_reproductive0.49731440
70MP0004145_abnormal_muscle_electrophysio0.48925916
71MP0003828_pulmonary_edema0.47906383
72MP0003699_abnormal_female_reproductive0.45849938
73MP0005636_abnormal_mineral_homeostasis0.45457045
74MP0002210_abnormal_sex_determination0.45312672
75MP0005076_abnormal_cell_differentiation0.42514312
76MP0005385_cardiovascular_system_phenoty0.42389884
77MP0001544_abnormal_cardiovascular_syste0.42389884
78MP0003091_abnormal_cell_migration0.40415901
79MP0000266_abnormal_heart_morphology0.39848265
80MP0000598_abnormal_liver_morphology0.39428324
81MP0003953_abnormal_hormone_level0.38866485
82MP0004381_abnormal_hair_follicle0.38728299
83MP0000759_abnormal_skeletal_muscle0.37631267
84MP0001958_emphysema0.37538400
85MP0010386_abnormal_urinary_bladder0.36900425
86MP0002295_abnormal_pulmonary_circulatio0.36330021
87MP0001545_abnormal_hematopoietic_system0.35019601
88MP0005397_hematopoietic_system_phenotyp0.35019601
89MP0005187_abnormal_penis_morphology0.32817710
90MP0003011_delayed_dark_adaptation0.32625026
91MP0005666_abnormal_adipose_tissue0.30871127
92MP0000427_abnormal_hair_cycle0.30838611
93MP0003191_abnormal_cellular_cholesterol0.29805193
94MP0010678_abnormal_skin_adnexa0.28807424
95MP0000627_abnormal_mammary_gland0.27910460
96MP0002925_abnormal_cardiovascular_devel0.27744889
97MP0000747_muscle_weakness0.27180425
98MP0002136_abnormal_kidney_physiology0.26875742
99MP0001614_abnormal_blood_vessel0.25606736
100MP0009379_abnormal_foot_pigmentation0.23486249

Predicted human phenotypes

RankGene SetZ-score
1Capillary hemangiomas (HP:0005306)9.75292741
2Hypergonadotropic hypogonadism (HP:0000815)8.87751465
3Upper limb muscle weakness (HP:0003484)8.60642127
4Decreased number of large peripheral myelinated nerve fibers (HP:0003387)8.47091446
5Abnormal pupillary function (HP:0007686)6.69332277
6Nonimmune hydrops fetalis (HP:0001790)6.47623552
7Muscle fibrillation (HP:0010546)6.46573209
8Tongue fasciculations (HP:0001308)6.18047275
9Abnormal auditory evoked potentials (HP:0006958)6.12789185
10Accelerated skeletal maturation (HP:0005616)6.01905178
11Female pseudohermaphroditism (HP:0010458)5.40304177
12Anosmia (HP:0000458)5.15336200
13Back pain (HP:0003418)4.41797324
14Lower limb asymmetry (HP:0100559)4.20069056
15Gynecomastia (HP:0000771)4.02398093
16Abnormality of the ischium (HP:0003174)3.92946668
17Basal cell carcinoma (HP:0002671)3.74452408
18Hypogonadotrophic hypogonadism (HP:0000044)3.70964796
19Bilateral microphthalmos (HP:0007633)3.55557074
20Long palpebral fissure (HP:0000637)3.32677313
21Onion bulb formation (HP:0003383)3.31908001
22Pseudobulbar signs (HP:0002200)3.29533816
23Primary amenorrhea (HP:0000786)3.22416122
24Long eyelashes (HP:0000527)3.11184773
25Abnormal pancreas size (HP:0012094)3.08674853
26Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.02466072
27Wormian bones (HP:0002645)2.98641845
28Genu valgum (HP:0002857)2.95457047
29Testicular neoplasm (HP:0010788)2.94973835
30Areflexia of lower limbs (HP:0002522)2.94811610
31Disproportionate tall stature (HP:0001519)2.92260899
32Abnormal sex determination (HP:0012244)2.87547874
33Sex reversal (HP:0012245)2.87547874
34Abnormality of the aortic arch (HP:0012303)2.87229664
35Venous insufficiency (HP:0005293)2.86335102
36Bilateral sensorineural hearing impairment (HP:0008619)2.79208360
37Delayed gross motor development (HP:0002194)2.71834680
38Peripheral demyelination (HP:0011096)2.68623360
39Difficulty walking (HP:0002355)2.62463200
40Decreased motor nerve conduction velocity (HP:0003431)2.61207470
41Polycythemia (HP:0001901)2.56259033
42Congenital ichthyosiform erythroderma (HP:0007431)2.55849242
43Bicornuate uterus (HP:0000813)2.45985131
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.44412357
45Abnormality of glycolipid metabolism (HP:0010969)2.44412357
46Abnormality of liposaccharide metabolism (HP:0010968)2.44412357
47Hematochezia (HP:0002573)2.40236779
48Venous abnormality (HP:0002624)2.37528695
49Asymmetric growth (HP:0100555)2.35154072
50Hypoplastic nipples (HP:0002557)2.33896895
51Hyperaldosteronism (HP:0000859)2.32978431
52Spontaneous hematomas (HP:0007420)2.31891293
53Abnormality of the pupil (HP:0000615)2.30556809
54Cardiovascular calcification (HP:0011915)2.28310877
55Fragile skin (HP:0001030)2.27946892
56Aplasia/Hypoplasia of the tibia (HP:0005772)2.27223361
57Short tibia (HP:0005736)2.25371830
58Flat cornea (HP:0007720)2.22297994
59Aplasia of the musculature (HP:0100854)2.19723431
60Arteriovenous malformation (HP:0100026)2.18935927
61Mutism (HP:0002300)2.08930240
62Distal lower limb muscle weakness (HP:0009053)2.08722256
63Aortic aneurysm (HP:0004942)2.07015348
64Hyporeflexia of lower limbs (HP:0002600)2.06938294
65Morphological abnormality of the middle ear (HP:0008609)2.06754829
66Hypoplasia of the uterus (HP:0000013)1.99669885
67Hypoplasia of the iris (HP:0007676)1.96841405
68Annular pancreas (HP:0001734)1.95121613
69Anophthalmia (HP:0000528)1.91284782
70Renal salt wasting (HP:0000127)1.90046344
71Blue sclerae (HP:0000592)1.87735039
72Ulnar deviation of finger (HP:0009465)1.83432390
73Decreased circulating renin level (HP:0003351)1.82523032
74Hypohidrosis (HP:0000966)1.79500110
75Sparse lateral eyebrow (HP:0005338)1.79428850
76Hyperpituitarism (HP:0010514)1.74948620
77Abnormal autonomic nervous system physiology (HP:0012332)1.74755230
78Confusion (HP:0001289)1.73825904
79Fasciculations (HP:0002380)1.72887762
80Ectopic kidney (HP:0000086)1.70059614
81Severe Myopia (HP:0011003)1.70037366
82Breast hypoplasia (HP:0003187)1.68870712
83Myotonia (HP:0002486)1.67030764
84Right ventricular cardiomyopathy (HP:0011663)1.66792997
85Abnormality of incisor morphology (HP:0011063)1.66358803
86Lymphedema (HP:0001004)1.66315483
87Osteolytic defects of the hand bones (HP:0009699)1.65510642
88Osteolytic defects of the phalanges of the hand (HP:0009771)1.65510642
89Vascular calcification (HP:0004934)1.65270912
90Cerebral aneurysm (HP:0004944)1.64769710
91Coarctation of aorta (HP:0001680)1.62799047
92Long clavicles (HP:0000890)1.60538903
93Knee flexion contracture (HP:0006380)1.59828472
94Deep philtrum (HP:0002002)1.59664910
95Overgrowth (HP:0001548)1.59053593
96Abnormality of the axillary hair (HP:0100134)1.58877527
97Abnormality of secondary sexual hair (HP:0009888)1.58877527
98Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.58449027
99Kyphoscoliosis (HP:0002751)1.50014567
100Conjunctival telangiectasia (HP:0000524)1.48486241

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDGFRA6.61619017
2AKT36.05942092
3DAPK24.57978845
4BLK2.75786086
5PDGFRB2.57529170
6ICK2.45230288
7MST42.23417047
8KDR10.2345540
9TIE11.80401819
10DAPK11.59137648
11PKN11.57659926
12NEK91.52408503
13ERBB41.47838493
14FRK1.26413671
15LATS11.26157368
16NME11.17237195
17MAP3K71.11860466
18DAPK31.07657205
19INSR1.05990310
20PDPK11.05455158
21RIPK11.04231695
22SRC1.03693534
23INSRR1.03579109
24RPS6KA20.99944582
25EGFR0.92404020
26STK380.84168653
27MET0.81631441
28RPS6KA60.73955475
29RPS6KL10.71799619
30RPS6KC10.71799619
31TRPM70.69207987
32MYLK0.66552201
33TYK20.65437367
34MAPK130.64851854
35PTK60.62205686
36TGFBR20.61982371
37AKT20.60172404
38STK100.58701903
39EPHA20.56893142
40JAK20.56599932
41PRKD20.56209741
42MARK20.54403420
43PDK10.50666459
44YES10.49862110
45PRKCZ0.49631928
46FES0.44691536
47PRKD10.43392883
48MAP2K10.40917748
49BRD40.39880451
50MTOR0.38813767
51MAPK110.38404740
52SGK4940.35311009
53SGK2230.35311009
54AURKB0.35232891
55PTK2B0.35014550
56CDC42BPA0.34579569
57PRKCQ0.34565321
58MAPK40.34199078
59FER0.33860688
60SGK10.32887999
61ERBB30.32602083
62MAP3K90.31714190
63LYN0.30340003
64MELK0.29276519
65PRKCA0.27391749
66PINK10.27025988
67PRKCE0.26879311
68DYRK1B0.26728898
69PIK3CA0.26650442
70LCK0.26197719
71PRKAA20.25886491
72MAP3K120.23935551
73ERBB20.23832593
74HCK0.23582796
75EPHB20.21205395
76PRKAA10.20844407
77MST1R0.19766892
78ROCK10.19644588
79MAPK10.19174404
80STK30.18513407
81CAMK40.17820798
82PTK20.15598000
83CAMK2G0.15409198
84KIT0.15005117
85ADRBK10.14984079
86SMG10.14786772
87PRKG20.13048071
88PRKCB0.12231689
89MAPK30.10686370
90TAF10.10488759
91TXK0.09552894
92MAPK80.09505135
93ROCK20.09371471
94RPS6KA10.09203191
95SGK30.09119254
96CAMK1D0.07588365
97ACVR1B0.05271707
98STK240.05256865
99SGK20.04417820
100MAP2K20.03790347

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049139.23333746
2Steroid hormone biosynthesis_Homo sapiens_hsa001408.13151506
3Jak-STAT signaling pathway_Homo sapiens_hsa046304.11386781
4Aldosterone synthesis and secretion_Homo sapiens_hsa049252.28281393
5Folate biosynthesis_Homo sapiens_hsa007902.25794076
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.15177388
7PI3K-Akt signaling pathway_Homo sapiens_hsa041512.08686093
8Sphingolipid metabolism_Homo sapiens_hsa006001.97878568
9N-Glycan biosynthesis_Homo sapiens_hsa005101.94987050
10Renin-angiotensin system_Homo sapiens_hsa046141.85134400
11Mineral absorption_Homo sapiens_hsa049781.82154957
12Histidine metabolism_Homo sapiens_hsa003401.32214201
13Inositol phosphate metabolism_Homo sapiens_hsa005621.30640529
14Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19518489
15Salivary secretion_Homo sapiens_hsa049701.18739614
16Vitamin digestion and absorption_Homo sapiens_hsa049771.13836727
17Axon guidance_Homo sapiens_hsa043601.08558030
18Focal adhesion_Homo sapiens_hsa045101.06504876
19Ras signaling pathway_Homo sapiens_hsa040141.05351215
20ECM-receptor interaction_Homo sapiens_hsa045121.05000712
21Tryptophan metabolism_Homo sapiens_hsa003801.04585440
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04028846
23Dorso-ventral axis formation_Homo sapiens_hsa043201.03526488
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97571937
25Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93473712
26Prolactin signaling pathway_Homo sapiens_hsa049170.92079396
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89877207
28Sphingolipid signaling pathway_Homo sapiens_hsa040710.87343976
29Renal cell carcinoma_Homo sapiens_hsa052110.86087318
30Rap1 signaling pathway_Homo sapiens_hsa040150.70328731
31Glycosaminoglycan degradation_Homo sapiens_hsa005310.68690776
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67855314
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65862426
34Malaria_Homo sapiens_hsa051440.64250265
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63406626
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60567530
37Thyroid hormone synthesis_Homo sapiens_hsa049180.58391383
38Bladder cancer_Homo sapiens_hsa052190.55370988
39Tight junction_Homo sapiens_hsa045300.53670591
40Proteoglycans in cancer_Homo sapiens_hsa052050.49394902
41Adherens junction_Homo sapiens_hsa045200.49313274
42HIF-1 signaling pathway_Homo sapiens_hsa040660.48487395
43Other glycan degradation_Homo sapiens_hsa005110.48481957
44Endocytosis_Homo sapiens_hsa041440.47469650
45Small cell lung cancer_Homo sapiens_hsa052220.45598942
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45143574
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43845748
48Complement and coagulation cascades_Homo sapiens_hsa046100.43476669
49Insulin resistance_Homo sapiens_hsa049310.42995342
50Prostate cancer_Homo sapiens_hsa052150.41764251
51TGF-beta signaling pathway_Homo sapiens_hsa043500.40825107
52FoxO signaling pathway_Homo sapiens_hsa040680.40273513
53ErbB signaling pathway_Homo sapiens_hsa040120.40203177
54Pathways in cancer_Homo sapiens_hsa052000.39315194
55Type II diabetes mellitus_Homo sapiens_hsa049300.38081554
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35788351
57GnRH signaling pathway_Homo sapiens_hsa049120.34922145
58Chronic myeloid leukemia_Homo sapiens_hsa052200.33819401
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33588410
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33370914
61Fatty acid biosynthesis_Homo sapiens_hsa000610.32061439
62Autoimmune thyroid disease_Homo sapiens_hsa053200.32043733
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.31504624
64Platelet activation_Homo sapiens_hsa046110.31150857
65Hippo signaling pathway_Homo sapiens_hsa043900.27493481
66Amoebiasis_Homo sapiens_hsa051460.27470814
67Acute myeloid leukemia_Homo sapiens_hsa052210.27269548
68MAPK signaling pathway_Homo sapiens_hsa040100.26289698
69Endometrial cancer_Homo sapiens_hsa052130.23470879
70ABC transporters_Homo sapiens_hsa020100.23225890
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22927464
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22685952
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.22446485
74Metabolic pathways_Homo sapiens_hsa011000.22383537
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21775579
76Choline metabolism in cancer_Homo sapiens_hsa052310.21701947
77Estrogen signaling pathway_Homo sapiens_hsa049150.19595491
78Glioma_Homo sapiens_hsa052140.17612031
79MicroRNAs in cancer_Homo sapiens_hsa052060.17344014
80Arginine and proline metabolism_Homo sapiens_hsa003300.17256145
81Lysosome_Homo sapiens_hsa041420.17165418
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17018655
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.16497756
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14710756
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14710619
86Gastric acid secretion_Homo sapiens_hsa049710.13352960
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12636606
88Insulin signaling pathway_Homo sapiens_hsa049100.11918153
89Nicotine addiction_Homo sapiens_hsa050330.11535603
90Melanoma_Homo sapiens_hsa052180.11388659
91Toxoplasmosis_Homo sapiens_hsa051450.11305374
92Regulation of autophagy_Homo sapiens_hsa041400.11228717
93Hepatitis B_Homo sapiens_hsa051610.10816568
94Olfactory transduction_Homo sapiens_hsa047400.10748503
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.10426133
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.09989766
97African trypanosomiasis_Homo sapiens_hsa051430.09948740
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.09869108
99Hepatitis C_Homo sapiens_hsa051600.09621826
100Circadian rhythm_Homo sapiens_hsa047100.09074871

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