PSG5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1type B pancreatic cell proliferation (GO:0044342)6.97133593
2protein heterotrimerization (GO:0070208)6.42688120
3collagen fibril organization (GO:0030199)6.33475944
4estrogen biosynthetic process (GO:0006703)5.65243683
5sequestering of extracellular ligand from receptor (GO:0035581)5.62477893
6cell migration involved in heart development (GO:0060973)5.55087893
7endocardial cushion development (GO:0003197)5.54639022
8bone trabecula formation (GO:0060346)5.34574892
9virion attachment to host cell (GO:0019062)5.32476005
10adhesion of symbiont to host cell (GO:0044650)5.32476005
11skin morphogenesis (GO:0043589)5.18434322
12blood vessel maturation (GO:0001955)4.99147147
13extracellular matrix assembly (GO:0085029)4.94752547
14mesenchymal-epithelial cell signaling (GO:0060638)4.71722844
15adhesion of symbiont to host (GO:0044406)4.52467056
16cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.41720550
17cellular response to vitamin (GO:0071295)4.35770564
18negative regulation of smooth muscle cell migration (GO:0014912)4.34414458
19endodermal cell differentiation (GO:0035987)4.29337183
20negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)4.20343426
21kidney mesenchyme development (GO:0072074)4.14870731
22extracellular negative regulation of signal transduction (GO:1900116)4.13800391
23extracellular regulation of signal transduction (GO:1900115)4.13800391
24regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.02784630
25chondrocyte proliferation (GO:0035988)3.98838400
26pericardium development (GO:0060039)3.93530091
27positive regulation of fibroblast migration (GO:0010763)3.91601325
28regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.89184932
29positive regulation of endothelial cell apoptotic process (GO:2000353)3.87651979
30vascular endothelial growth factor signaling pathway (GO:0038084)3.85719001
31negative regulation of axon extension involved in axon guidance (GO:0048843)3.82750866
32metanephric mesenchyme development (GO:0072075)3.81297897
33negative regulation of leukocyte chemotaxis (GO:0002689)3.80051148
34regulation of plasminogen activation (GO:0010755)3.79413346
35hyaluronan catabolic process (GO:0030214)3.74981195
36tooth mineralization (GO:0034505)3.63649732
37negative regulation of osteoblast proliferation (GO:0033689)3.61548404
38cell migration involved in sprouting angiogenesis (GO:0002042)3.59061209
39collagen metabolic process (GO:0032963)3.55278543
40negative regulation of BMP signaling pathway (GO:0030514)3.45918622
41regulation of integrin-mediated signaling pathway (GO:2001044)3.45604459
42* female pregnancy (GO:0007565)3.44530040
43dermatan sulfate biosynthetic process (GO:0030208)3.43028496
44glomerular basement membrane development (GO:0032836)3.40984622
45extracellular fibril organization (GO:0043206)3.38856590
46cellular response to vitamin D (GO:0071305)3.37790908
47negative regulation of bone remodeling (GO:0046851)3.36627537
48smooth muscle tissue development (GO:0048745)3.33935968
49collagen catabolic process (GO:0030574)3.33566966
50cellular response to interferon-alpha (GO:0035457)3.33267314
51dermatan sulfate metabolic process (GO:0030205)3.32837191
52endothelial cell morphogenesis (GO:0001886)3.32633038
53sprouting angiogenesis (GO:0002040)3.31752938
54negative regulation of axon guidance (GO:1902668)3.30672354
55heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.24541830
56multicellular organismal macromolecule metabolic process (GO:0044259)3.24369797
57fibril organization (GO:0097435)3.22280625
58response to magnesium ion (GO:0032026)3.19842695
59regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.18789443
60neuron projection extension involved in neuron projection guidance (GO:1902284)3.15787608
61axon extension involved in axon guidance (GO:0048846)3.15787608
62regulation of gonadotropin secretion (GO:0032276)3.15069023
63positive regulation of blood vessel endothelial cell migration (GO:0043536)3.14731906
64endocrine hormone secretion (GO:0060986)3.13315891
65negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.10780253
66cell adhesion mediated by integrin (GO:0033627)3.10770139
67multicellular organismal metabolic process (GO:0044236)3.07643127
68embryonic forelimb morphogenesis (GO:0035115)3.06371332
69regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.05703560
70middle ear morphogenesis (GO:0042474)3.04122054
71substrate-dependent cell migration (GO:0006929)3.03800466
72negative regulation of fatty acid transport (GO:2000192)3.03657219
73negative regulation of nitric-oxide synthase activity (GO:0051001)3.03335943
74anterior/posterior axis specification, embryo (GO:0008595)3.02643377
75multicellular organismal catabolic process (GO:0044243)3.02527540
76eyelid development in camera-type eye (GO:0061029)2.99712365
77basement membrane organization (GO:0071711)2.99012708
78face morphogenesis (GO:0060325)2.98497550
79positive regulation of cartilage development (GO:0061036)2.97576919
80regulation of organ formation (GO:0003156)2.95548836
81positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.94647694
82extracellular matrix disassembly (GO:0022617)2.92589266
83regulation of extracellular matrix disassembly (GO:0010715)2.92048008
84lymphangiogenesis (GO:0001946)2.91667053
85embryonic cranial skeleton morphogenesis (GO:0048701)2.91412845
86outer ear morphogenesis (GO:0042473)2.91295318
87activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.88991480
88positive regulation of catecholamine secretion (GO:0033605)2.87567575
89negative regulation of embryonic development (GO:0045992)2.87209739
90regulation of transforming growth factor beta1 production (GO:0032908)2.86502491
91extracellular matrix organization (GO:0030198)2.85182400
92extracellular structure organization (GO:0043062)2.84265117
93estrogen metabolic process (GO:0008210)2.83111504
94ventricular septum development (GO:0003281)2.83018426
95response to follicle-stimulating hormone (GO:0032354)2.80716307
96regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.80557940
97protein localization to cell surface (GO:0034394)2.79895468
98venous blood vessel morphogenesis (GO:0048845)2.79418964
99vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.79224910
100apoptotic cell clearance (GO:0043277)2.76883697

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.89095343
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse5.46815907
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.37308720
4* BRD4_25478319_ChIP-Seq_HGPS_Human3.62648103
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.53496643
6CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse3.08445866
7WT1_19549856_ChIP-ChIP_CCG9911_Human2.96762339
8TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.91076644
9* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.77023531
10CJUN_26792858_Chip-Seq_BT549_Human2.70579193
11ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.58594427
12RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.57342460
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.47341051
14EP300_21415370_ChIP-Seq_HL-1_Mouse2.25187103
15* TP53_18474530_ChIP-ChIP_U2OS_Human2.22727304
16NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.21931789
17NRF2_20460467_ChIP-Seq_MEFs_Mouse2.21931789
18CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.21832442
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15651208
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05937449
21JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.01531175
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.99421249
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96474039
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95637147
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.90699645
26TP53_16413492_ChIP-PET_HCT116_Human1.90289964
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.79234987
28JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77228811
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76421161
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76421161
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65590538
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61654182
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60347624
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57324710
35SA1_22415368_ChIP-Seq_MEFs_Mouse1.55408786
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.55296733
37SMC1_22415368_ChIP-Seq_MEFs_Mouse1.54208577
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54070704
39EGR1_19032775_ChIP-ChIP_M12_Human1.50447397
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.48253105
41TP53_20018659_ChIP-ChIP_R1E_Mouse1.46189402
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44848791
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41523840
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40049449
45* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.38811156
46AHR_22903824_ChIP-Seq_MCF-7_Human1.37224832
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35504923
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34656316
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32274654
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32274654
51TP53_22127205_ChIP-Seq_IMR90_Human1.30420737
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30110195
53ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.29799281
54SMC3_22415368_ChIP-Seq_MEFs_Mouse1.28069823
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.23093529
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20453936
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19139328
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.18526637
59MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.18464456
60GBX2_23144817_ChIP-Seq_PC3_Human1.14966156
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14527732
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14504490
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.14408101
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.13816157
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.13788465
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.13387811
67TP53_23651856_ChIP-Seq_MEFs_Mouse1.12649827
68* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10705895
69SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09037751
70CLOCK_20551151_ChIP-Seq_293T_Human1.06933362
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01347202
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01112875
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00728469
74SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99912198
75PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.98117506
76* UBF1/2_26484160_Chip-Seq_HMECs_Human0.97838870
77SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97551484
78BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96426410
79SOX2_20726797_ChIP-Seq_SW620_Human0.94623105
80P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94172505
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93705209
82TP63_23658742_ChIP-Seq_EP156T_Human0.92509514
83PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90042470
84PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89383875
85ISL1_27105846_Chip-Seq_CPCs_Mouse0.88988846
86TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88823375
87TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88089716
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84858355
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84330339
90TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.83930977
91WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83667216
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83635556
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82809347
94ESR2_21235772_ChIP-Seq_MCF-7_Human0.82795163
95PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.82097280
96NFI_21473784_ChIP-Seq_ESCs_Mouse0.81432748
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81178530
98NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80976871
99TBX20_22080862_ChIP-Seq_HEART_Mouse0.80524173
100TBX20_22328084_ChIP-Seq_HEART_Mouse0.80524173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.21880937
2MP0005503_abnormal_tendon_morphology6.09240465
3MP0001958_emphysema4.61443057
4MP0003279_aneurysm4.30990283
5MP0003705_abnormal_hypodermis_morpholog4.27217176
6MP0005275_abnormal_skin_tensile4.13786015
7MP0006054_spinal_hemorrhage3.93674076
8MP0009384_cardiac_valve_regurgitation3.73080277
9MP0004272_abnormal_basement_membrane3.61883464
10MP0001542_abnormal_bone_strength3.32250474
11MP0005257_abnormal_intraocular_pressure3.20154906
12MP0002295_abnormal_pulmonary_circulatio2.44046955
13MP0003950_abnormal_plasma_membrane2.31754619
14MP0010368_abnormal_lymphatic_system2.26078652
15MP0003941_abnormal_skin_development2.14226806
16MP0005508_abnormal_skeleton_morphology2.10390006
17MP0005023_abnormal_wound_healing2.06754458
18MP0009780_abnormal_chondrocyte_physiolo1.95592531
19MP0001348_abnormal_lacrimal_gland1.86989500
20MP0000013_abnormal_adipose_tissue1.85661526
21MP0001243_abnormal_dermal_layer1.80471095
22MP0000767_abnormal_smooth_muscle1.79642613
23MP0002108_abnormal_muscle_morphology1.79343784
24MP0005623_abnormal_meninges_morphology1.76969711
25MP0010386_abnormal_urinary_bladder1.75092176
26MP0002060_abnormal_skin_morphology1.67179634
27MP0003566_abnormal_cell_adhesion1.63224409
28MP0003091_abnormal_cell_migration1.58251952
29MP0009250_abnormal_appendicular_skeleto1.54951789
30MP0001299_abnormal_eye_distance/1.46299966
31MP0000534_abnormal_ureter_morphology1.40586719
32MP0005595_abnormal_vascular_smooth1.34100299
33MP0010352_gastrointestinal_tract_polyps1.33833589
34MP0002896_abnormal_bone_mineralization1.33448103
35MP0003942_abnormal_urinary_system1.28026802
36MP0000751_myopathy1.25223356
37MP0009697_abnormal_copulation1.24887792
38MP0005390_skeleton_phenotype1.23908721
39MP0004858_abnormal_nervous_system1.13267485
40MP0000003_abnormal_adipose_tissue1.08512187
41MP0002115_abnormal_skeleton_extremities1.04521167
42MP0003283_abnormal_digestive_organ1.03162603
43MP0009053_abnormal_anal_canal0.92545959
44MP0000428_abnormal_craniofacial_morphol0.89293009
45MP0000049_abnormal_middle_ear0.89220927
46MP0000163_abnormal_cartilage_morphology0.87369831
47MP0000759_abnormal_skeletal_muscle0.87357840
48MP0000538_abnormal_urinary_bladder0.87078928
49MP0003385_abnormal_body_wall0.84295761
50MP0002128_abnormal_blood_circulation0.83469676
51MP0005171_absent_coat_pigmentation0.83346488
52MP0005164_abnormal_response_to0.83321573
53MP0003795_abnormal_bone_structure0.79159837
54MP0002163_abnormal_gland_morphology0.78945034
55MP0004134_abnormal_chest_morphology0.78687145
56MP0002998_abnormal_bone_remodeling0.75137770
57MP0003448_altered_tumor_morphology0.75066838
58MP0002113_abnormal_skeleton_development0.74789486
59MP0000749_muscle_degeneration0.74664937
60MP0001879_abnormal_lymphatic_vessel0.73599557
61MP0002254_reproductive_system_inflammat0.72452406
62MP0005197_abnormal_uvea_morphology0.71638494
63MP0010030_abnormal_orbit_morphology0.67453136
64MP0000432_abnormal_head_morphology0.66595080
65MP0006276_abnormal_autonomic_nervous0.66383975
66MP0002282_abnormal_trachea_morphology0.64453076
67MP0002133_abnormal_respiratory_system0.63749358
68MP0005388_respiratory_system_phenotype0.63749358
69MP0000230_abnormal_systemic_arterial0.63736452
70MP0000733_abnormal_muscle_development0.62421956
71MP0000681_abnormal_thyroid_gland0.60592996
72MP0004883_abnormal_blood_vessel0.59655911
73MP0003115_abnormal_respiratory_system0.57751721
74MP0002168_other_aberrant_phenotype0.57502702
75MP0001756_abnormal_urination0.56916216
76MP0003959_abnormal_lean_body0.56867752
77MP0001533_abnormal_skeleton_physiology0.56282766
78MP0001614_abnormal_blood_vessel0.56220238
79MP0001175_abnormal_lung_morphology0.56203474
80MP0002116_abnormal_craniofacial_bone0.56189448
81MP0002933_joint_inflammation0.55706968
82MP0003937_abnormal_limbs/digits/tail_de0.55508057
83MP0002109_abnormal_limb_morphology0.55361957
84MP0005193_abnormal_anterior_eye0.53058092
85MP0003755_abnormal_palate_morphology0.52707833
86MP0000762_abnormal_tongue_morphology0.50960033
87MP0003252_abnormal_bile_duct0.48543750
88MP0001270_distended_abdomen0.48374708
89MP0002114_abnormal_axial_skeleton0.47985490
90MP0003186_abnormal_redox_activity0.46727843
91MP0002177_abnormal_outer_ear0.45872947
92MP0000569_abnormal_digit_pigmentation0.45063683
93MP0002932_abnormal_joint_morphology0.44538742
94MP0003191_abnormal_cellular_cholesterol0.44118893
95MP0005620_abnormal_muscle_contractility0.41161207
96MP0003828_pulmonary_edema0.40904744
97MP0000639_abnormal_adrenal_gland0.40409095
98MP0005389_reproductive_system_phenotype0.40379578
99MP0000467_abnormal_esophagus_morphology0.40163288
100MP0009840_abnormal_foam_cell0.39634688

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)8.07568559
2Protrusio acetabuli (HP:0003179)7.92021663
3Aortic aneurysm (HP:0004942)6.09703063
4Ankle contracture (HP:0006466)5.28829565
5Vascular tortuosity (HP:0004948)5.25922300
6Aortic dissection (HP:0002647)5.17611437
7Soft skin (HP:0000977)4.90618385
8Follicular hyperkeratosis (HP:0007502)4.71521582
9Bladder diverticulum (HP:0000015)4.41073239
10Type 1 muscle fiber predominance (HP:0003803)4.33642485
11Abnormality of dentin (HP:0010299)4.22427556
12Neonatal short-limb short stature (HP:0008921)4.17989996
13Broad metatarsal (HP:0001783)4.14741233
14Wormian bones (HP:0002645)4.11017271
15Cervical subluxation (HP:0003308)3.95492962
16Atrophic scars (HP:0001075)3.81447900
17Arterial tortuosity (HP:0005116)3.80420373
18Slender build (HP:0001533)3.69633893
19Spinal rigidity (HP:0003306)3.69484166
20Genu recurvatum (HP:0002816)3.60148857
21Bowel diverticulosis (HP:0005222)3.58163414
22Dilatation of the ascending aorta (HP:0005111)3.57465301
23Fragile skin (HP:0001030)3.57092050
24Peritonitis (HP:0002586)3.55791194
25Shallow orbits (HP:0000586)3.40082845
26Nonimmune hydrops fetalis (HP:0001790)3.30499061
27Blue sclerae (HP:0000592)3.29037924
28Vertebral compression fractures (HP:0002953)3.11259184
29Aortic regurgitation (HP:0001659)3.07716573
30Coronal craniosynostosis (HP:0004440)3.07199274
31Spondylolisthesis (HP:0003302)3.05336046
32Biconcave vertebral bodies (HP:0004586)3.05079208
33Overgrowth (HP:0001548)2.90060807
34Wide anterior fontanel (HP:0000260)2.89185443
35Mitral regurgitation (HP:0001653)2.84793130
36Mesomelia (HP:0003027)2.83405880
37Sparse lateral eyebrow (HP:0005338)2.80691374
38Aortic valve stenosis (HP:0001650)2.79056502
39Joint laxity (HP:0001388)2.76535928
40Hypoventilation (HP:0002791)2.73848173
41Redundant skin (HP:0001582)2.72319673
42Elbow flexion contracture (HP:0002987)2.68522234
43Hyperextensible skin (HP:0000974)2.59852400
44Mild short stature (HP:0003502)2.54900732
45Abnormal delivery (HP:0001787)2.54643054
46Increased variability in muscle fiber diameter (HP:0003557)2.52679546
47Abnormality of the acetabulum (HP:0003170)2.52460279
48Wrist flexion contracture (HP:0001239)2.50226358
49Morphological abnormality of the middle ear (HP:0008609)2.48736432
50Mitral valve prolapse (HP:0001634)2.48687691
51Mildly elevated creatine phosphokinase (HP:0008180)2.47459997
52Aneurysm (HP:0002617)2.43348866
53Joint stiffness (HP:0001387)2.43325859
54Ovoid vertebral bodies (HP:0003300)2.42115190
55Osteolytic defects of the hand bones (HP:0009699)2.24416566
56Osteolytic defects of the phalanges of the hand (HP:0009771)2.24416566
57Aplasia of the musculature (HP:0100854)2.18569670
58Cardiovascular calcification (HP:0011915)2.17799001
59Breech presentation (HP:0001623)2.12174247
60Deviation of the hallux (HP:0010051)2.12052171
61Delayed closure of the anterior fontanelle (HP:0001476)2.10639171
62Broad ribs (HP:0000885)2.07363353
63Delayed gross motor development (HP:0002194)2.06703762
64Abnormality of proline metabolism (HP:0010907)2.06450393
65Hydroxyprolinuria (HP:0003080)2.06450393
66Flared iliac wings (HP:0002869)2.06295303
67Abnormality of skeletal muscle fiber size (HP:0012084)2.03919176
68Round ear (HP:0100830)2.03798617
69Flat cornea (HP:0007720)2.03483499
70Inguinal hernia (HP:0000023)1.99129736
71Natal tooth (HP:0000695)1.98829781
72Long toe (HP:0010511)1.98693528
73Ulnar bowing (HP:0003031)1.97893506
74Camptodactyly of toe (HP:0001836)1.97850745
75Mitral stenosis (HP:0001718)1.97487510
76Abnormality of skull ossification (HP:0002703)1.97166359
77Ectopia lentis (HP:0001083)1.93484662
78Hallux valgus (HP:0001822)1.92932245
79Absent frontal sinuses (HP:0002688)1.89267926
80Disproportionate tall stature (HP:0001519)1.87242876
81Protruding ear (HP:0000411)1.86662857
82Increased connective tissue (HP:0009025)1.86515341
83Tarsal synostosis (HP:0008368)1.86422178
84Osteoarthritis (HP:0002758)1.85528455
85Delayed cranial suture closure (HP:0000270)1.84324804
86Thoracolumbar scoliosis (HP:0002944)1.83003496
87Renal duplication (HP:0000075)1.81904535
88Broad long bones (HP:0005622)1.81783297
89Limb-girdle muscle weakness (HP:0003325)1.79890964
90Emphysema (HP:0002097)1.78794019
91Premature skin wrinkling (HP:0100678)1.78561836
92Generalized amyotrophy (HP:0003700)1.78121629
93Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.77450585
94Partial duplication of the phalanx of hand (HP:0009999)1.76949895
95Decreased skull ossification (HP:0004331)1.73664846
96Ulnar deviation of the wrist (HP:0003049)1.73388426
97Infantile muscular hypotonia (HP:0008947)1.72141642
98Deformed tarsal bones (HP:0008119)1.72095124
99Bell-shaped thorax (HP:0001591)1.71527943
100Distal upper limb amyotrophy (HP:0007149)1.70668606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK6.44257988
2AKT35.05123834
3PDGFRA4.47950257
4NEK94.02759889
5DDR23.95949732
6LIMK12.80780030
7PAK22.71755207
8PRKD22.31481384
9RIPK12.14978803
10PTK22.12450809
11TESK11.99589107
12TTN1.93153666
13PIK3CG1.91037208
14STK381.90901111
15TGFBR21.73251015
16GRK71.72145831
17LATS11.71319456
18NTRK11.69203154
19KIT1.68293154
20PDGFRB1.56861414
21CDC42BPA1.52395623
22EPHB21.50117986
23ADRBK11.45691811
24ERN11.38024151
25PTK2B1.36419036
26TRPM71.34427987
27LATS21.33040476
28KDR1.25184542
29FLT31.24166153
30DAPK31.24106528
31ERBB41.19196026
32ABL21.18267754
33PAK31.16383527
34PAK61.13636620
35ROCK11.07309397
36ADRBK21.06434026
37PAK40.98804604
38MAP3K120.98727545
39PIM20.96147128
40RPS6KA20.90669126
41MAPK70.89334078
42SIK10.87097000
43ILK0.86535832
44MET0.85612774
45MOS0.85240030
46TYK20.83972240
47MAPKAPK30.83190271
48ROCK20.82064835
49GRK10.80580822
50MAP2K10.78948723
51TRIB30.77379886
52GRK50.75775390
53JAK10.74228305
54PRKG20.72901915
55PLK20.72830993
56PRKCE0.71428633
57PRKD10.63411997
58PRKCH0.60555772
59MTOR0.60233429
60CAMK2G0.59961119
61MAP3K60.59049285
62ICK0.56124166
63GSK3A0.53683076
64TAOK20.52225756
65MELK0.50107202
66PAK10.49957219
67MAP2K30.49483864
68RPS6KC10.48603500
69RPS6KL10.48603500
70STK30.46727155
71MAP3K30.45696272
72INSR0.45692856
73PRKD30.45249753
74SRC0.44323291
75RPS6KA60.43741480
76JAK30.42816703
77DMPK0.42696560
78FRK0.40344793
79DYRK1B0.39653341
80MAP3K70.38860390
81TBK10.34976577
82PINK10.34342020
83EPHB10.33399096
84TGFBR10.33302909
85ABL10.31833851
86MARK20.31462248
87MAPK110.29793016
88ERBB30.29202999
89PRKCD0.27660399
90PDPK10.25467828
91CAMK2D0.24954211
92CDK80.24697535
93BRSK20.24424590
94MAPKAPK20.23888286
95PKN10.23808767
96DAPK20.23724983
97CAMK10.23388103
98MAPK40.20713610
99PIK3CA0.20137161
100PKN20.20022626

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.52135467
2Focal adhesion_Homo sapiens_hsa045103.33568160
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.13100727
4Glycosaminoglycan degradation_Homo sapiens_hsa005313.03038665
5Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.89641060
6Protein digestion and absorption_Homo sapiens_hsa049742.61344519
7Proteoglycans in cancer_Homo sapiens_hsa052052.29579758
8PI3K-Akt signaling pathway_Homo sapiens_hsa041512.08541108
9Ovarian steroidogenesis_Homo sapiens_hsa049131.87472021
10Regulation of actin cytoskeleton_Homo sapiens_hsa048101.79395074
11Amoebiasis_Homo sapiens_hsa051461.78003801
12Other glycan degradation_Homo sapiens_hsa005111.69233006
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.68396336
14Melanoma_Homo sapiens_hsa052181.66437729
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.62569934
16Dilated cardiomyopathy_Homo sapiens_hsa054141.60075639
17Bladder cancer_Homo sapiens_hsa052191.57647538
18Hedgehog signaling pathway_Homo sapiens_hsa043401.57215183
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.56978472
20TGF-beta signaling pathway_Homo sapiens_hsa043501.53132943
21Malaria_Homo sapiens_hsa051441.50436045
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.49460974
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.48092584
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.44737390
25Hippo signaling pathway_Homo sapiens_hsa043901.36609080
26Axon guidance_Homo sapiens_hsa043601.24091121
27N-Glycan biosynthesis_Homo sapiens_hsa005101.22003930
28Renin-angiotensin system_Homo sapiens_hsa046141.20606049
29Lysosome_Homo sapiens_hsa041421.19513449
30Basal cell carcinoma_Homo sapiens_hsa052171.19261561
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.18370613
32Adherens junction_Homo sapiens_hsa045201.18051104
33Sulfur metabolism_Homo sapiens_hsa009201.17663603
34Melanogenesis_Homo sapiens_hsa049161.14454786
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12949350
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09693098
37Vascular smooth muscle contraction_Homo sapiens_hsa042701.07510867
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07348956
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07002124
40Rap1 signaling pathway_Homo sapiens_hsa040151.04680593
41Small cell lung cancer_Homo sapiens_hsa052221.03514445
42Pathways in cancer_Homo sapiens_hsa052001.03317424
43MicroRNAs in cancer_Homo sapiens_hsa052061.03139994
44Sphingolipid metabolism_Homo sapiens_hsa006001.01211592
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99321958
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93752117
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92542059
48Ras signaling pathway_Homo sapiens_hsa040140.91721839
49p53 signaling pathway_Homo sapiens_hsa041150.90133365
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88496955
51Platelet activation_Homo sapiens_hsa046110.87246950
52Endocytosis_Homo sapiens_hsa041440.86143405
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.83847913
54Vibrio cholerae infection_Homo sapiens_hsa051100.82631217
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80311510
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78568670
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78136480
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.77417478
59Wnt signaling pathway_Homo sapiens_hsa043100.77131553
60Gap junction_Homo sapiens_hsa045400.74632427
61Tight junction_Homo sapiens_hsa045300.73011302
62Prostate cancer_Homo sapiens_hsa052150.72504613
63Phagosome_Homo sapiens_hsa041450.71436805
64Cocaine addiction_Homo sapiens_hsa050300.70752714
65Calcium signaling pathway_Homo sapiens_hsa040200.70619545
66Shigellosis_Homo sapiens_hsa051310.70233426
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.69992979
68TNF signaling pathway_Homo sapiens_hsa046680.68542902
69Thyroid hormone synthesis_Homo sapiens_hsa049180.68103474
70Complement and coagulation cascades_Homo sapiens_hsa046100.67513663
71Mineral absorption_Homo sapiens_hsa049780.66777656
72Selenocompound metabolism_Homo sapiens_hsa004500.64620536
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64244402
74MAPK signaling pathway_Homo sapiens_hsa040100.64069832
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59932454
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59583302
77cAMP signaling pathway_Homo sapiens_hsa040240.59220916
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56967370
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56850807
80Oxytocin signaling pathway_Homo sapiens_hsa049210.56534113
81Dorso-ventral axis formation_Homo sapiens_hsa043200.52538039
82Gastric acid secretion_Homo sapiens_hsa049710.49441815
83Hepatitis B_Homo sapiens_hsa051610.46772105
84Pertussis_Homo sapiens_hsa051330.46683325
85Salivary secretion_Homo sapiens_hsa049700.45926757
86Glioma_Homo sapiens_hsa052140.45148851
87GnRH signaling pathway_Homo sapiens_hsa049120.42616938
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.42231866
89Prion diseases_Homo sapiens_hsa050200.42097458
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41828206
91Insulin secretion_Homo sapiens_hsa049110.40111158
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39521561
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.39143497
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.37865859
95Cholinergic synapse_Homo sapiens_hsa047250.35915423
96Estrogen signaling pathway_Homo sapiens_hsa049150.35359529
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34528669
98Prolactin signaling pathway_Homo sapiens_hsa049170.33156399
99Inositol phosphate metabolism_Homo sapiens_hsa005620.31793040
100HTLV-I infection_Homo sapiens_hsa051660.30932398

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