ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	* female pregnancy (GO:0007565)	8.73873620
2	regulation of gonadotropin secretion (GO:0032276)	8.66999823
3	response to follicle-stimulating hormone (GO:0032354)	8.39046225
4	glucocorticoid biosynthetic process (GO:0006704)	7.87739555
5	keratinization (GO:0031424)	7.75753318
6	estrogen metabolic process (GO:0008210)	7.68114855
7	androgen biosynthetic process (GO:0006702)	7.15076131
8	androgen metabolic process (GO:0008209)	6.67215075
9	* multi-multicellular organism process (GO:0044706)	6.39066189
10	prostate gland growth (GO:0060736)	6.18346103
11	parturition (GO:0007567)	5.71535720
12	* multi-organism reproductive process (GO:0044703)	5.53941614
13	sphingoid metabolic process (GO:0046519)	5.01789820
14	glucocorticoid metabolic process (GO:0008211)	4.97490033
15	hormone biosynthetic process (GO:0042446)	4.75404140
16	response to gonadotropin (GO:0034698)	4.74643526
17	regulation of transforming growth factor beta1 production (GO:0032908)	4.35180921
18	positive regulation of cellular amide metabolic process (GO:0034250)	4.33446555
19	endocrine hormone secretion (GO:0060986)	4.29483213
20	establishment of skin barrier (GO:0061436)	4.27998924
21	positive regulation of growth hormone secretion (GO:0060124)	4.24544727
22	myoblast fusion (GO:0007520)	4.10006958
23	positive regulation of p38MAPK cascade (GO:1900745)	4.05647550
24	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-	3.93626317
25	syncytium formation (GO:0006949)	3.87120413
26	vascular endothelial growth factor signaling pathway (GO:0038084)	3.84814637
27	JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)	3.84403131
28	sphingosine metabolic process (GO:0006670)	3.78876630
29	positive regulation of interleukin-8 secretion (GO:2000484)	3.73527554
30	regulation of water loss via skin (GO:0033561)	3.73081626
31	skin morphogenesis (GO:0043589)	3.70681716
32	sequestering of extracellular ligand from receptor (GO:0035581)	3.69129667
33	lymphangiogenesis (GO:0001946)	3.62850408
34	syncytium formation by plasma membrane fusion (GO:0000768)	3.57507718
35	regulation of interleukin-8 secretion (GO:2000482)	3.51874443
36	progesterone metabolic process (GO:0042448)	3.49354599
37	C21-steroid hormone biosynthetic process (GO:0006700)	3.38883039
38	vitamin transmembrane transport (GO:0035461)	3.36173546
39	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	3.35215013
40	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	3.35215013
41	positive regulation of protein kinase C signaling (GO:0090037)	3.32089101
42	diol metabolic process (GO:0034311)	3.30860331
43	endocardial cushion development (GO:0003197)	3.26781182
44	import into cell (GO:0098657)	3.25259514
45	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	3.24561874
46	iron ion import (GO:0097286)	3.22646827
47	mesenchymal-epithelial cell signaling (GO:0060638)	3.18386454
48	regulation of growth hormone secretion (GO:0060123)	3.17771512
49	sprouting angiogenesis (GO:0002040)	3.17181982
50	vascular endothelial growth factor receptor signaling pathway (GO:0048010)	3.11651332
51	collagen fibril organization (GO:0030199)	3.09234445
52	negative regulation of activin receptor signaling pathway (GO:0032926)	3.03695722
53	desmosome organization (GO:0002934)	3.03318621
54	smooth muscle tissue development (GO:0048745)	2.99519516
55	type B pancreatic cell proliferation (GO:0044342)	2.98691286
56	eyelid development in camera-type eye (GO:0061029)	2.97550885
57	collecting duct development (GO:0072044)	2.89406463
58	ovulation cycle (GO:0042698)	2.88792067
59	glomerular basement membrane development (GO:0032836)	2.86892224
60	regulation of p38MAPK cascade (GO:1900744)	2.85914530
61	positive regulation of glomerulus development (GO:0090193)	2.84085613
62	endodermal cell differentiation (GO:0035987)	2.83211271
63	lymph vessel development (GO:0001945)	2.82555516
64	surfactant homeostasis (GO:0043129)	2.81412872
65	cellular response to vitamin (GO:0071295)	2.80191078
66	keratinocyte development (GO:0003334)	2.80113297
67	hemidesmosome assembly (GO:0031581)	2.73834469
68	bone trabecula formation (GO:0060346)	2.72849597
69	keratinocyte differentiation (GO:0030216)	2.72364183
70	positive regulation of insulin receptor signaling pathway (GO:0046628)	2.71990297
71	negative regulation of cell-matrix adhesion (GO:0001953)	2.71594039
72	regulation of steroid hormone biosynthetic process (GO:0090030)	2.69730475
73	glomerular visceral epithelial cell development (GO:0072015)	2.68010038
74	Leydig cell differentiation (GO:0033327)	2.67823097
75	cell adhesion mediated by integrin (GO:0033627)	2.60997024
76	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	2.60469840
77	hyaluronan catabolic process (GO:0030214)	2.59152051
78	mesodermal cell differentiation (GO:0048333)	2.57170654
79	regulation of integrin-mediated signaling pathway (GO:2001044)	2.55315915
80	positive regulation of transforming growth factor beta production (GO:0071636)	2.54228479
81	negative regulation of myoblast differentiation (GO:0045662)	2.53904154
82	bone morphogenesis (GO:0060349)	2.52247776
83	negative regulation of complement activation (GO:0045916)	2.50460769
84	wound healing, spreading of epidermal cells (GO:0035313)	2.49686408
85	cellular hormone metabolic process (GO:0034754)	2.47275619
86	plasma membrane repair (GO:0001778)	2.46349037
87	cellular response to gonadotropin stimulus (GO:0071371)	2.44048417
88	cellular response to vitamin D (GO:0071305)	2.42821794
89	negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)	2.42578365
90	polarized epithelial cell differentiation (GO:0030859)	2.41582260
91	ovulation from ovarian follicle (GO:0001542)	2.39801085
92	basement membrane organization (GO:0071711)	2.36832217
93	extracellular negative regulation of signal transduction (GO:1900116)	2.35878681
94	extracellular regulation of signal transduction (GO:1900115)	2.35878681
95	regulation of hippo signaling (GO:0035330)	2.33390570
96	C21-steroid hormone metabolic process (GO:0008207)	2.33384560
97	pericardium development (GO:0060039)	2.32960708
98	cell-substrate junction assembly (GO:0007044)	2.32703288
99	keratinocyte proliferation (GO:0043616)	2.31340032
100	estrogen biosynthetic process (GO:0006703)	16.5970514

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	6.47980089
2	TRIM28_21343339_ChIP-Seq_HEK293_Human	3.41064641
3	EGR1_19032775_ChIP-ChIP_M12_Human	3.23488277
4	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.92888469
5	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.84665380
6	TP53_18474530_ChIP-ChIP_U2OS_Human	2.82374094
7	* BRD4_25478319_ChIP-Seq_HGPS_Human	2.55352208
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.47167900
9	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.46184480
10	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.46063550
11	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	2.33983876
12	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.32795764
13	CJUN_26792858_Chip-Seq_BT549_Human	2.29438137
14	* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	2.20087871
15	AHR_22903824_ChIP-Seq_MCF-7_Human	2.15146790
16	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.08431317
17	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	2.04212770
18	PPAR_26484153_Chip-Seq_NCI-H1993_Human	2.04045034
19	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.99664467
20	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.99019528
21	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.97506015
22	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.95399358
23	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.95336720
24	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.95336720
25	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.90789774
26	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.90789774
27	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.90471854
28	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.85802951
29	TP53_16413492_ChIP-PET_HCT116_Human	1.85228102
30	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.84311949
31	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.84260872
32	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.80374376
33	TP63_23658742_ChIP-Seq_EP156T_Human	1.78209299
34	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.76790262
35	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.67993571
36	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.60345264
37	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.50876251
38	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.50062041
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.49680895
40	TAF15_26573619_Chip-Seq_HEK293_Human	1.48401872
41	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.44897867
42	GBX2_23144817_ChIP-Seq_PC3_Human	1.42449288
43	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.41627363
44	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.40218234
45	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.38540629
46	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.38531128
47	* RXR_22108803_ChIP-Seq_LS180_Human	1.36288210
48	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.35711011
49	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.33819945
50	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.32158306
51	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.26048088
52	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.22322024
53	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.20420575
54	SOX2_20726797_ChIP-Seq_SW620_Human	1.17970596
55	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.16564395
56	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.16086023
57	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.15623215
58	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	1.14726528
59	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.13982005
60	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.12104957
61	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.10741225
62	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.09112931
63	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.08873196
64	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.06687183
65	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.06388348
66	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.05997748
67	SMAD4_21799915_ChIP-Seq_A2780_Human	1.05215381
68	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.04805733
69	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.04492488
70	P300_19829295_ChIP-Seq_ESCs_Human	1.03797253
71	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.03253357
72	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.99907942
73	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.99085752
74	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97644791
75	* CDX2_22108803_ChIP-Seq_LS180_Human	0.95863776
76	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.94815943
77	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.92848305
78	CBP_20019798_ChIP-Seq_JUKART_Human	0.92848305
79	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.91072739
80	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.90993740
81	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.90993740
82	UBF1/2_26484160_Chip-Seq_HMECs_Human	0.90311478
83	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.87742279
84	GATA4_25053715_ChIP-Seq_YYC3_Human	0.87651584
85	JUN_21703547_ChIP-Seq_K562_Human	0.87479093
86	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.85101040
87	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.83774737
88	TCF4_23295773_ChIP-Seq_U87_Human	0.81985048
89	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.81967938
90	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.81556891
91	VDR_24787735_ChIP-Seq_THP-1_Human	0.81246625
92	* AR_25329375_ChIP-Seq_VCAP_Human	0.79470974
93	* SMAD3_21741376_ChIP-Seq_EPCs_Human	0.79445036
94	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.79324845
95	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.78664478
96	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.77588090
97	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.77430312
98	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.77151604
99	ER_23166858_ChIP-Seq_MCF-7_Human	0.76844094
100	TBL1_22424771_ChIP-Seq_293T_Human	0.76520646

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009697_abnormal_copulation	6.65146308
2	MP0003941_abnormal_skin_development	5.16081471
3	MP0003950_abnormal_plasma_membrane	4.55838309
4	MP0008438_abnormal_cutaneous_collagen	4.15447862
5	MP0005275_abnormal_skin_tensile	3.94362836
6	MP0010368_abnormal_lymphatic_system	2.97463766
7	MP0002163_abnormal_gland_morphology	2.95444050
8	MP0004272_abnormal_basement_membrane	2.86718863
9	MP0005503_abnormal_tendon_morphology	2.79430670
10	MP0002796_impaired_skin_barrier	2.70818626
11	MP0000013_abnormal_adipose_tissue	2.48603308
12	MP0006276_abnormal_autonomic_nervous	2.45092768
13	MP0003705_abnormal_hypodermis_morpholog	2.41861624
14	MP0005257_abnormal_intraocular_pressure	2.41662588
15	MP0003191_abnormal_cellular_cholesterol	2.36296119
16	MP0006054_spinal_hemorrhage	2.28791966
17	MP0009384_cardiac_valve_regurgitation	2.18208598
18	MP0005647_abnormal_sex_gland	2.16106261
19	MP0005023_abnormal_wound_healing	2.14806537
20	MP0005379_endocrine/exocrine_gland_phen	2.10426635
21	MP0001958_emphysema	2.04414808
22	MP0000003_abnormal_adipose_tissue	1.98040610
23	MP0002876_abnormal_thyroid_physiology	1.94982157
24	MP0010234_abnormal_vibrissa_follicle	1.89739605
25	MP0010386_abnormal_urinary_bladder	1.86851095
26	MP0002060_abnormal_skin_morphology	1.73259375
27	MP0001919_abnormal_reproductive_system	1.71318353
28	MP0003959_abnormal_lean_body	1.62729787
29	MP0003279_aneurysm	1.60206830
30	MP0003566_abnormal_cell_adhesion	1.57419748
31	MP0003183_abnormal_peptide_metabolism	1.56524403
32	MP0009780_abnormal_chondrocyte_physiolo	1.54154029
33	MP0010352_gastrointestinal_tract_polyps	1.53767595
34	MP0001542_abnormal_bone_strength	1.51681859
35	MP0005187_abnormal_penis_morphology	1.47269339
36	MP0000579_abnormal_nail_morphology	1.46389796
37	MP0001440_abnormal_grooming_behavior	1.40439912
38	MP0002295_abnormal_pulmonary_circulatio	1.34657842
39	MP0005501_abnormal_skin_physiology	1.33151965
40	MP0003453_abnormal_keratinocyte_physiol	1.31413954
41	MP0005646_abnormal_pituitary_gland	1.31302614
42	MP0000639_abnormal_adrenal_gland	1.29387556
43	MP0003091_abnormal_cell_migration	1.27837637
44	MP0010678_abnormal_skin_adnexa	1.26771596
45	MP0004947_skin_inflammation	1.19760372
46	MP0006138_congestive_heart_failure	1.18112363
47	MP0003936_abnormal_reproductive_system	1.17807315
48	MP0002998_abnormal_bone_remodeling	1.15740204
49	MP0002971_abnormal_brown_adipose	1.15603984
50	MP0005389_reproductive_system_phenotype	1.13348143
51	MP0010771_integument_phenotype	1.12320467
52	MP0000647_abnormal_sebaceous_gland	1.07801623
53	MP0001879_abnormal_lymphatic_vessel	1.04854566
54	MP0004782_abnormal_surfactant_physiolog	1.02728385
55	MP0004019_abnormal_vitamin_homeostasis	1.02340577
56	MP0001243_abnormal_dermal_layer	1.02301370
57	MP0001299_abnormal_eye_distance/	1.01753423
58	MP0001756_abnormal_urination	1.01166770
59	MP0009115_abnormal_fat_cell	0.92327204
60	MP0000383_abnormal_hair_follicle	0.89729609
61	MP0000767_abnormal_smooth_muscle	0.85902455
62	MP0000230_abnormal_systemic_arterial	0.85866695
63	MP0005375_adipose_tissue_phenotype	0.85677563
64	MP0003828_pulmonary_edema	0.83779891
65	MP0000534_abnormal_ureter_morphology	0.82608924
66	MP0002896_abnormal_bone_mineralization	0.82534559
67	MP0000681_abnormal_thyroid_gland	0.82236671
68	MP0005360_urolithiasis	0.81087536
69	MP0001216_abnormal_epidermal_layer	0.80277479
70	MP0005508_abnormal_skeleton_morphology	0.78682028
71	MP0002108_abnormal_muscle_morphology	0.77442685
72	MP0005595_abnormal_vascular_smooth	0.75321700
73	MP0002128_abnormal_blood_circulation	0.73528074
74	MP0003252_abnormal_bile_duct	0.69692218
75	MP0000367_abnormal_coat/_hair	0.69027418
76	MP0000627_abnormal_mammary_gland	0.68770487
77	MP0000427_abnormal_hair_cycle	0.68149489
78	MP0009053_abnormal_anal_canal	0.66357063
79	MP0000759_abnormal_skeletal_muscle	0.64899661
80	MP0002098_abnormal_vibrissa_morphology	0.64570314
81	MP0000762_abnormal_tongue_morphology	0.62386611
82	MP0003868_abnormal_feces_composition	0.60542788
83	MP0005164_abnormal_response_to	0.60379188
84	MP0003045_fibrosis	0.57117566
85	MP0005334_abnormal_fat_pad	0.56473068
86	MP0004085_abnormal_heartbeat	0.56360103
87	MP0004084_abnormal_cardiac_muscle	0.56017589
88	MP0005197_abnormal_uvea_morphology	0.55543895
89	MP0004233_abnormal_muscle_weight	0.54796127
90	MP0010329_abnormal_lipoprotein_level	0.54624086
91	MP0001348_abnormal_lacrimal_gland	0.53244630
92	MP0002138_abnormal_hepatobiliary_system	0.53233480
93	MP0002972_abnormal_cardiac_muscle	0.51204505
94	MP0003795_abnormal_bone_structure	0.50442628
95	MP0001666_abnormal_nutrient_absorption	0.50248659
96	MP0002269_muscular_atrophy	0.48984665
97	MP0001915_intracranial_hemorrhage	0.48740402
98	MP0005058_abnormal_lysosome_morphology	0.47732482
99	MP0005623_abnormal_meninges_morphology	0.47551077
100	MP0002136_abnormal_kidney_physiology	0.46903853

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital ichthyosiform erythroderma (HP:0007431)	5.71611829
2	Follicular hyperkeratosis (HP:0007502)	5.37183557
3	Abnormality of nail color (HP:0100643)	4.83182683
4	Protrusio acetabuli (HP:0003179)	4.75589553
5	Aortic aneurysm (HP:0004942)	4.50771663
6	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	4.48967114
7	Premature rupture of membranes (HP:0001788)	4.44432027
8	Capillary hemangiomas (HP:0005306)	3.83703723
9	Wormian bones (HP:0002645)	3.69802902
10	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.59723586
11	Hypergonadotropic hypogonadism (HP:0000815)	3.57398211
12	Upper limb muscle weakness (HP:0003484)	3.56776921
13	Abnormality of liposaccharide metabolism (HP:0010968)	3.48667123
14	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.48667123
15	Abnormality of glycolipid metabolism (HP:0010969)	3.48667123
16	Nonimmune hydrops fetalis (HP:0001790)	3.46036084
17	Aortic dissection (HP:0002647)	3.45142760
18	Abnormality of proline metabolism (HP:0010907)	3.28879205
19	Hydroxyprolinuria (HP:0003080)	3.28879205
20	Ankle contracture (HP:0006466)	3.23634151
21	Osteolytic defects of the hand bones (HP:0009699)	3.14364722
22	Osteolytic defects of the phalanges of the hand (HP:0009771)	3.14364722
23	Spondylolisthesis (HP:0003302)	3.12141277
24	Vascular tortuosity (HP:0004948)	3.07612607
25	Atrophic scars (HP:0001075)	3.05456815
26	Parakeratosis (HP:0001036)	3.03318308
27	Cervical subluxation (HP:0003308)	2.96273453
28	Cardiovascular calcification (HP:0011915)	2.94126878
29	Fragile skin (HP:0001030)	2.82135174
30	Mitral stenosis (HP:0001718)	2.80757428
31	Thyroid-stimulating hormone excess (HP:0002925)	2.80186676
32	Natal tooth (HP:0000695)	2.76457461
33	Hypohidrosis (HP:0000966)	2.66555181
34	Palmoplantar hyperkeratosis (HP:0000972)	2.64902717
35	Vertebral compression fractures (HP:0002953)	2.64596483
36	Asymmetric septal hypertrophy (HP:0001670)	2.61433770
37	Absent frontal sinuses (HP:0002688)	2.60596130
38	Accelerated skeletal maturation (HP:0005616)	2.55229828
39	Arterial tortuosity (HP:0005116)	2.52945378
40	Soft skin (HP:0000977)	2.51491221
41	Broad metatarsal (HP:0001783)	2.49966033
42	Thick nail (HP:0001805)	2.39690150
43	Palmar hyperkeratosis (HP:0010765)	2.39495000
44	Ectropion (HP:0000656)	2.39465169
45	Flared iliac wings (HP:0002869)	2.36338967
46	Abnormal auditory evoked potentials (HP:0006958)	2.36279239
47	Blue sclerae (HP:0000592)	2.34945765
48	Neonatal short-limb short stature (HP:0008921)	2.34626595
49	Neonatal hypoglycemia (HP:0001998)	2.32748777
50	Elbow flexion contracture (HP:0002987)	2.28383428
51	Tongue fasciculations (HP:0001308)	2.28108287
52	Muscle fibrillation (HP:0010546)	2.24574789
53	Spinal cord lesions (HP:0100561)	2.24092133
54	Syringomyelia (HP:0003396)	2.24092133
55	Plantar hyperkeratosis (HP:0007556)	2.20716833
56	Type 1 muscle fiber predominance (HP:0003803)	2.20186840
57	Ovoid vertebral bodies (HP:0003300)	2.19700919
58	Bradycardia (HP:0001662)	2.18002363
59	Knee flexion contracture (HP:0006380)	2.17316468
60	Vascular calcification (HP:0004934)	2.16406391
61	Overgrowth (HP:0001548)	2.15759706
62	Increased IgE level (HP:0003212)	2.14694578
63	Autoamputation (HP:0001218)	2.14458182
64	Erythema (HP:0010783)	2.14207302
65	Abnormal pupillary function (HP:0007686)	2.13934261
66	Long eyelashes (HP:0000527)	2.13727104
67	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	2.10183714
68	Hyporeflexia of lower limbs (HP:0002600)	2.09736451
69	Corneal dystrophy (HP:0001131)	2.08943212
70	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.08878926
71	Aortic regurgitation (HP:0001659)	2.05402641
72	Dilatation of the ascending aorta (HP:0005111)	2.04244741
73	Hypoplasia of the iris (HP:0007676)	2.03450000
74	Dysostosis multiplex (HP:0000943)	2.03180770
75	Enlarged penis (HP:0000040)	2.02847378
76	Delayed closure of the anterior fontanelle (HP:0001476)	2.02559940
77	Corneal erosion (HP:0200020)	2.00367233
78	Bladder diverticulum (HP:0000015)	1.99278793
79	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.97733076
80	Persistence of primary teeth (HP:0006335)	1.96950016
81	Areflexia of lower limbs (HP:0002522)	1.96788530
82	Distal lower limb muscle weakness (HP:0009053)	1.95926524
83	Abnormality of the frontal sinuses (HP:0002687)	1.95764717
84	Urinary glycosaminoglycan excretion (HP:0003541)	1.94716483
85	Mucopolysacchariduria (HP:0008155)	1.94716483
86	Aortic valve stenosis (HP:0001650)	1.94546116
87	Sparse lateral eyebrow (HP:0005338)	1.92197578
88	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.91532454
89	Abnormality of polysaccharide metabolism (HP:0011012)	1.91532454
90	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.91532454
91	Spinal rigidity (HP:0003306)	1.91421289
92	Thoracolumbar scoliosis (HP:0002944)	1.86065645
93	Broad ribs (HP:0000885)	1.85015944
94	Tetraparesis (HP:0002273)	1.82693670
95	Abnormality of dentin (HP:0010299)	1.82078511
96	Erythroderma (HP:0001019)	1.80924712
97	Shallow orbits (HP:0000586)	1.79356609
98	Gonadotropin excess (HP:0000837)	1.78351018
99	Testicular neoplasm (HP:0010788)	1.77614174
100	Short nail (HP:0001799)	1.76399285

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	AKT3	5.73852222
2	PDGFRA	4.51925341
3	KDR	4.32376873
4	EPHA2	4.30522750
5	MYLK	4.20152749
6	NEK9	3.15590443
7	PAK2	2.93949988
8	LATS1	2.77326723
9	MAP3K12	2.75938255
10	FRK	2.19770291
11	PDGFRB	2.13433360
12	MET	2.07070416
13	TRPM7	2.03788901
14	MST1R	1.94066993
15	ADRBK2	1.79308571
16	DDR2	1.76813936
17	PTK2	1.70038376
18	ADRBK1	1.61461604
19	ERBB4	1.49345982
20	INSRR	1.33479953
21	DAPK2	1.32046771
22	SCYL2	1.29646402
23	FLT3	1.24715386
24	ICK	1.23980542
25	TGFBR2	1.23366243
26	STK38	1.22962108
27	PDK2	1.21829884
28	MST4	1.20536583
29	GRK7	1.19661056
30	ABL2	1.07201940
31	PKN1	1.05169106
32	RIPK1	1.04469971
33	MOS	1.03197126
34	MAPKAPK3	1.03111008
35	NTRK1	1.02409714
36	DAPK3	0.99165562
37	PTK2B	0.92465621
38	PRKD2	0.91032044
39	TTN	0.89974368
40	STK3	0.89366200
41	MAP2K1	0.87027146
42	PRKCE	0.84178223
43	STK38L	0.82137869
44	STK24	0.80363028
45	PAK4	0.77871879
46	EIF2AK3	0.76151356
47	LATS2	0.74071354
48	MELK	0.73568723
49	RPS6KA2	0.72057964
50	BLK	0.66531139
51	MAPK11	0.61402062
52	MTOR	0.61168730
53	DAPK1	0.60686068
54	INSR	0.59536833
55	BMPR2	0.58366808
56	BMX	0.58314015
57	ROCK1	0.58127394
58	TIE1	0.56768693
59	PRKG2	0.55049595
60	MAP3K9	0.54948614
61	MAP3K3	0.53156523
62	MAP3K6	0.50479931
63	EEF2K	0.49933516
64	SRC	0.49882623
65	ERN1	0.49825100
66	CDC42BPA	0.49617382
67	MAP3K7	0.49539910
68	ILK	0.48582039
69	GRK5	0.47578112
70	PDPK1	0.47251936
71	ACVR1B	0.47232267
72	PINK1	0.46776436
73	FER	0.46344081
74	PRKAA2	0.45895935
75	PIM2	0.43168121
76	PIK3CG	0.41862429
77	STK10	0.38857977
78	EPHB2	0.38519698
79	JAK1	0.38297564
80	AKT2	0.36234313
81	MAP2K3	0.36104483
82	TGFBR1	0.34308694
83	CAMK2G	0.33299488
84	EGFR	0.31002867
85	RPS6KA6	0.30227364
86	IRAK3	0.28762055
87	DYRK3	0.28347267
88	ABL1	0.28276571
89	PAK6	0.27901088
90	RPS6KC1	0.27332135
91	RPS6KL1	0.27332135
92	TAOK2	0.25999651
93	WNK1	0.25733713
94	ROCK2	0.25335797
95	PRKCA	0.24764026
96	ERBB3	0.24301962
97	PRKD1	0.23953913
98	GRK1	0.23476929
99	PIK3CA	0.22075729
100	KIT	0.21103050

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ovarian steroidogenesis_Homo sapiens_hsa04913	6.37895397
2	Steroid hormone biosynthesis_Homo sapiens_hsa00140	5.86014970
3	ECM-receptor interaction_Homo sapiens_hsa04512	3.12169689
4	Sphingolipid metabolism_Homo sapiens_hsa00600	2.87508620
5	Jak-STAT signaling pathway_Homo sapiens_hsa04630	2.55200444
6	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.51267402
7	Focal adhesion_Homo sapiens_hsa04510	2.11444615
8	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	1.87865780
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.78723791
10	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.55446873
11	Renin-angiotensin system_Homo sapiens_hsa04614	1.49845753
12	ABC transporters_Homo sapiens_hsa02010	1.46204569
13	Prolactin signaling pathway_Homo sapiens_hsa04917	1.35495326
14	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.32350685
15	Complement and coagulation cascades_Homo sapiens_hsa04610	1.30508641
16	Circadian rhythm_Homo sapiens_hsa04710	1.24239090
17	Proteoglycans in cancer_Homo sapiens_hsa05205	1.21595175
18	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.19733839
19	Other glycan degradation_Homo sapiens_hsa00511	1.19210839
20	Lysosome_Homo sapiens_hsa04142	1.17050190
21	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.16851054
22	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.16032869
23	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.11580201
24	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	1.09771074
25	Amoebiasis_Homo sapiens_hsa05146	1.06644790
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.06424336
27	Salivary secretion_Homo sapiens_hsa04970	1.05565781
28	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.02094149
29	Mineral absorption_Homo sapiens_hsa04978	0.99857953
30	Small cell lung cancer_Homo sapiens_hsa05222	0.99079840
31	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.98183556
32	Ras signaling pathway_Homo sapiens_hsa04014	0.95219911
33	p53 signaling pathway_Homo sapiens_hsa04115	0.94268707
34	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.89414254
35	Adherens junction_Homo sapiens_hsa04520	0.88710539
36	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.88212023
37	Bladder cancer_Homo sapiens_hsa05219	0.88006795
38	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.87860174
39	Platelet activation_Homo sapiens_hsa04611	0.86301297
40	Linoleic acid metabolism_Homo sapiens_hsa00591	0.85655498
41	Malaria_Homo sapiens_hsa05144	0.84950092
42	Protein digestion and absorption_Homo sapiens_hsa04974	0.82802247
43	Endocytosis_Homo sapiens_hsa04144	0.82788731
44	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.82006153
45	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.81076240
46	Tight junction_Homo sapiens_hsa04530	0.80319750
47	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.79478844
48	Melanoma_Homo sapiens_hsa05218	0.79200877
49	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.78784823
50	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.78354145
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.77880108
52	Axon guidance_Homo sapiens_hsa04360	0.71964589
53	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.70088325
54	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.68191110
55	Hippo signaling pathway_Homo sapiens_hsa04390	0.67860034
56	Rap1 signaling pathway_Homo sapiens_hsa04015	0.65210572
57	Tryptophan metabolism_Homo sapiens_hsa00380	0.63643631
58	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.62467184
59	Renal cell carcinoma_Homo sapiens_hsa05211	0.61963869
60	MicroRNAs in cancer_Homo sapiens_hsa05206	0.59833526
61	Pathways in cancer_Homo sapiens_hsa05200	0.59678782
62	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.57108681
63	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.56509655
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.54824608
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.53661415
66	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.53596783
67	Retinol metabolism_Homo sapiens_hsa00830	0.53351348
68	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.52686260
69	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.51493928
70	Folate biosynthesis_Homo sapiens_hsa00790	0.50786245
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.50480550
72	Toxoplasmosis_Homo sapiens_hsa05145	0.49823803
73	Phagosome_Homo sapiens_hsa04145	0.48959276
74	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.47946869
75	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.47155771
76	GnRH signaling pathway_Homo sapiens_hsa04912	0.46943338
77	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.45879363
78	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.45399910
79	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.44333796
80	Rheumatoid arthritis_Homo sapiens_hsa05323	0.43701988
81	African trypanosomiasis_Homo sapiens_hsa05143	0.42864430
82	Histidine metabolism_Homo sapiens_hsa00340	0.42632135
83	ErbB signaling pathway_Homo sapiens_hsa04012	0.41759013
84	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.40463754
85	MAPK signaling pathway_Homo sapiens_hsa04010	0.40266953
86	FoxO signaling pathway_Homo sapiens_hsa04068	0.39775817
87	Ether lipid metabolism_Homo sapiens_hsa00565	0.38755258
88	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.38513412
89	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.37641500
90	Olfactory transduction_Homo sapiens_hsa04740	0.35857751
91	Estrogen signaling pathway_Homo sapiens_hsa04915	0.35099682
92	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.31853951
93	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.31745927
94	TNF signaling pathway_Homo sapiens_hsa04668	0.31704760
95	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.30843069
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.30672501
97	Phototransduction_Homo sapiens_hsa04744	0.30531967
98	Prostate cancer_Homo sapiens_hsa05215	0.30291337
99	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.29273065
100	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.28933931

PSG7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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