PSG8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glucocorticoid biosynthetic process (GO:0006704)9.94030609
2androgen biosynthetic process (GO:0006702)8.77372495
3prostate gland growth (GO:0060736)8.67947822
4multi-multicellular organism process (GO:0044706)8.66037585
5androgen metabolic process (GO:0008209)7.81115247
6multi-organism reproductive process (GO:0044703)7.50708857
7sphingoid metabolic process (GO:0046519)7.05341557
8negative regulation of cytosolic calcium ion concentration (GO:0051481)6.28144991
9sphingosine metabolic process (GO:0006670)6.12710564
10vitamin transmembrane transport (GO:0035461)6.06989268
11hormone biosynthetic process (GO:0042446)6.04677548
12glucocorticoid metabolic process (GO:0008211)5.81700627
13positive regulation of growth hormone secretion (GO:0060124)5.80272097
14diol metabolic process (GO:0034311)5.39108451
15myoblast fusion (GO:0007520)5.32991614
16opioid receptor signaling pathway (GO:0038003)5.04519066
17response to gonadotropin (GO:0034698)5.01627937
18parturition (GO:0007567)4.96027226
19negative regulation of cAMP-mediated signaling (GO:0043951)4.95873939
20positive regulation of protein kinase C signaling (GO:0090037)4.90729274
21syncytium formation (GO:0006949)4.88613245
22positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-4.87387296
23collecting duct development (GO:0072044)4.70545767
24behavioral response to ethanol (GO:0048149)4.66856081
25syncytium formation by plasma membrane fusion (GO:0000768)4.63244280
26lymphangiogenesis (GO:0001946)4.51828910
27endocrine hormone secretion (GO:0060986)4.43694416
28JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)4.41513659
29positive regulation of cAMP-mediated signaling (GO:0043950)4.39983614
30regulation of acrosome reaction (GO:0060046)4.37965527
31adult feeding behavior (GO:0008343)4.20587279
32negative regulation of cell-matrix adhesion (GO:0001953)3.96778650
33vascular endothelial growth factor signaling pathway (GO:0038084)3.88712374
34regulation of growth hormone secretion (GO:0060123)3.86244301
35negative regulation of activin receptor signaling pathway (GO:0032926)3.77896136
36regulation of G0 to G1 transition (GO:0070316)3.56883540
37wound healing, spreading of epidermal cells (GO:0035313)3.55410797
38regulation of translational termination (GO:0006449)3.55062313
39ether lipid metabolic process (GO:0046485)3.46521120
40ovulation cycle (GO:0042698)3.32633779
41thrombin receptor signaling pathway (GO:0070493)3.28240316
42smooth muscle tissue development (GO:0048745)3.22034809
43negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.19672399
44negative regulation of nitric oxide biosynthetic process (GO:0045019)3.19067077
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.18075546
46cellular hormone metabolic process (GO:0034754)3.15928483
47regulation of protein glycosylation (GO:0060049)3.14856810
48regulation of hippo signaling (GO:0035330)3.09583891
49cellular response to ammonium ion (GO:0071242)3.02395135
50estrogen biosynthetic process (GO:0006703)22.5265577
51establishment of protein localization to Golgi (GO:0072600)2.99403405
52protein targeting to Golgi (GO:0000042)2.99062455
53polyol biosynthetic process (GO:0046173)2.98344026
54cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.96862463
55vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.92246817
56artery development (GO:0060840)2.92109729
57sequestering of extracellular ligand from receptor (GO:0035581)2.89073395
58glomerular visceral epithelial cell development (GO:0072015)2.86799937
59bone morphogenesis (GO:0060349)2.80358663
60sprouting angiogenesis (GO:0002040)2.77065935
61retrograde transport, vesicle recycling within Golgi (GO:0000301)2.75753019
62progesterone metabolic process (GO:0042448)2.75280129
63ether metabolic process (GO:0018904)2.71542773
64lymph vessel development (GO:0001945)2.70661104
65polarized epithelial cell differentiation (GO:0030859)2.64222848
66negative regulation of glycoprotein biosynthetic process (GO:0010561)2.62562334
67notochord development (GO:0030903)2.61395321
68thyroid hormone generation (GO:0006590)2.61008126
69UDP-N-acetylglucosamine metabolic process (GO:0006047)2.59619825
70protein-chromophore linkage (GO:0018298)2.58219077
71regulation of calcium ion-dependent exocytosis (GO:0017158)2.57268098
72surfactant homeostasis (GO:0043129)2.57048271
73adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.56197519
74glycosphingolipid metabolic process (GO:0006687)2.55824785
75steroid catabolic process (GO:0006706)2.54773978
76iron ion import (GO:0097286)2.53520964
77C21-steroid hormone biosynthetic process (GO:0006700)2.51911997
78negative regulation of cell-substrate adhesion (GO:0010812)2.51486453
79positive regulation of insulin receptor signaling pathway (GO:0046628)2.49879241
80skin morphogenesis (GO:0043589)2.47276985
81striated muscle atrophy (GO:0014891)2.46616410
82Leydig cell differentiation (GO:0033327)2.46409135
83myelin maintenance (GO:0043217)2.45682960
84fibroblast migration (GO:0010761)2.45345501
85eyelid development in camera-type eye (GO:0061029)2.44238355
86piRNA metabolic process (GO:0034587)2.44176625
87regulation of protein kinase C signaling (GO:0090036)2.44056342
88glomerular epithelial cell development (GO:0072310)2.43335304
89regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.42065320
90protein localization to Golgi apparatus (GO:0034067)2.40260083
91regulation of cAMP-mediated signaling (GO:0043949)2.37386211
92glycerol ether metabolic process (GO:0006662)2.36568295
93regulation of interferon-gamma biosynthetic process (GO:0045072)2.36076718
94hormone metabolic process (GO:0042445)2.34577716
95regulation of endocrine process (GO:0044060)2.33147284
96adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)2.32190236
97female pregnancy (GO:0007565)11.7399577
98response to follicle-stimulating hormone (GO:0032354)10.5339974
99regulation of gonadotropin secretion (GO:0032276)10.4978685
100estrogen metabolic process (GO:0008210)10.3794456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human8.07200099
2EGR1_19032775_ChIP-ChIP_M12_Human4.29673038
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.97581846
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.83257244
5BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.46381450
6AHR_22903824_ChIP-Seq_MCF-7_Human2.45464325
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.35301966
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.31179814
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.28831984
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.25948775
11* TRIM28_17542650_ChIP-ChIP_NTERA2_Human2.20571910
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.17295629
13* TP53_18474530_ChIP-ChIP_U2OS_Human2.15044262
14ARNT_22903824_ChIP-Seq_MCF-7_Human2.08496472
15* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.03318749
16PPAR_26484153_Chip-Seq_NCI-H1993_Human1.94249935
17RXR_22108803_ChIP-Seq_LS180_Human1.91958138
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.90697283
19P63_26484246_Chip-Seq_KERATINOCYTES_Human1.87927663
20* BRD4_25478319_ChIP-Seq_HGPS_Human1.78213753
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73017115
22CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.69094116
23ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.68777349
24CJUN_26792858_Chip-Seq_BT549_Human1.68598908
25JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64948226
26ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64531508
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.62187909
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60480409
29POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.60480409
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.59079212
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57344944
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55164915
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.49736453
34TP63_23658742_ChIP-Seq_EP156T_Human1.48262408
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47206588
36NANOG_19829295_ChIP-Seq_ESCs_Human1.45753619
37SOX2_19829295_ChIP-Seq_ESCs_Human1.45753619
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38924892
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.38331537
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35017310
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34726960
42HTT_18923047_ChIP-ChIP_STHdh_Human1.31140969
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29701511
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25348939
45TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23108219
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21639347
47CBP_20019798_ChIP-Seq_JUKART_Human1.20534823
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20534823
49GBX2_23144817_ChIP-Seq_PC3_Human1.20067596
50TAF15_26573619_Chip-Seq_HEK293_Human1.18943655
51GATA3_24758297_ChIP-Seq_MCF-7_Human1.18881140
52P300_19829295_ChIP-Seq_ESCs_Human1.18523047
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18425203
54ER_23166858_ChIP-Seq_MCF-7_Human1.17965235
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17819887
56GATA4_25053715_ChIP-Seq_YYC3_Human1.17344181
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16677503
58SMAD3_21741376_ChIP-Seq_HESCs_Human1.16022604
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.16016213
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.16016213
61TP53_16413492_ChIP-PET_HCT116_Human1.15190559
62AR_21572438_ChIP-Seq_LNCaP_Human1.13996906
63PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13123609
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13115913
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13115913
66IGF1R_20145208_ChIP-Seq_DFB_Human1.12658244
67CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09709841
68VDR_22108803_ChIP-Seq_LS180_Human1.09388707
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08876153
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08876153
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08596986
72JUN_21703547_ChIP-Seq_K562_Human1.08475718
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.07599866
74SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07107020
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05208791
76CDX2_22108803_ChIP-Seq_LS180_Human1.05065720
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04717576
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03884450
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03235384
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.02837121
81* TCF4_23295773_ChIP-Seq_U87_Human1.02633194
82AR_25329375_ChIP-Seq_VCAP_Human1.02458676
83SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00687953
84TP63_22573176_ChIP-Seq_HFKS_Human1.00062307
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00002869
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99720635
87RUNX2_22187159_ChIP-Seq_PCA_Human0.97771112
88PRDM14_20953172_ChIP-Seq_ESCs_Human0.96374827
89FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95488769
90STAT3_23295773_ChIP-Seq_U87_Human0.94693096
91JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93689835
92FOXA2_19822575_ChIP-Seq_HepG2_Human0.92396733
93AR_19668381_ChIP-Seq_PC3_Human0.92388748
94FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92078330
95FOXA1_25329375_ChIP-Seq_VCAP_Human0.92078330
96SOX2_20726797_ChIP-Seq_SW620_Human0.91704932
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91549587
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.90811606
99KLF4_19829295_ChIP-Seq_ESCs_Human0.90160437
100SMAD3_21741376_ChIP-Seq_EPCs_Human0.89243450

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation8.74757928
2MP0002163_abnormal_gland_morphology4.80546775
3MP0003941_abnormal_skin_development4.23758580
4MP0005379_endocrine/exocrine_gland_phen4.11911627
5MP0009780_abnormal_chondrocyte_physiolo3.75654679
6MP0002876_abnormal_thyroid_physiology3.52295148
7MP0006276_abnormal_autonomic_nervous3.10588577
8MP0003950_abnormal_plasma_membrane2.96483051
9MP0010368_abnormal_lymphatic_system2.95923886
10MP0005647_abnormal_sex_gland2.82205120
11MP0001919_abnormal_reproductive_system2.66595557
12MP0005503_abnormal_tendon_morphology2.66074442
13MP0000013_abnormal_adipose_tissue2.43747114
14MP0006054_spinal_hemorrhage2.39559212
15MP0003959_abnormal_lean_body2.31925782
16MP0005083_abnormal_biliary_tract2.06141561
17MP0000003_abnormal_adipose_tissue2.02366146
18MP0002971_abnormal_brown_adipose1.86239166
19MP0004019_abnormal_vitamin_homeostasis1.86140008
20MP0005646_abnormal_pituitary_gland1.80518914
21MP0001440_abnormal_grooming_behavior1.76393848
22MP0005389_reproductive_system_phenotype1.72670062
23MP0003011_delayed_dark_adaptation1.68574681
24MP0003936_abnormal_reproductive_system1.57586906
25MP0000681_abnormal_thyroid_gland1.52695772
26MP0009278_abnormal_bone_marrow1.49459816
27MP0010386_abnormal_urinary_bladder1.48752194
28MP0000639_abnormal_adrenal_gland1.45637233
29MP0005023_abnormal_wound_healing1.44729491
30MP0003183_abnormal_peptide_metabolism1.44285507
31MP0008438_abnormal_cutaneous_collagen1.36299805
32MP0003566_abnormal_cell_adhesion1.34798159
33MP0009115_abnormal_fat_cell1.25879974
34MP0003191_abnormal_cellular_cholesterol1.25696113
35MP0005085_abnormal_gallbladder_physiolo1.24527838
36MP0004272_abnormal_basement_membrane1.23554526
37MP0000230_abnormal_systemic_arterial1.23186152
38MP0005360_urolithiasis1.18824971
39MP0001968_abnormal_touch/_nociception1.18674062
40MP0001756_abnormal_urination1.16031938
41MP0006138_congestive_heart_failure1.12161940
42MP0009384_cardiac_valve_regurgitation1.11970573
43MP0001666_abnormal_nutrient_absorption1.11541393
44MP0005377_hearing/vestibular/ear_phenot1.08739119
45MP0003878_abnormal_ear_physiology1.08739119
46MP0008875_abnormal_xenobiotic_pharmacok1.08383464
47MP0005275_abnormal_skin_tensile1.08381331
48MP0000647_abnormal_sebaceous_gland1.03823949
49MP0003705_abnormal_hypodermis_morpholog1.00429348
50MP0002998_abnormal_bone_remodeling0.99258347
51MP0010352_gastrointestinal_tract_polyps0.98087074
52MP0005334_abnormal_fat_pad0.95069846
53MP0009703_decreased_birth_body0.93455501
54MP0003045_fibrosis0.91474336
55MP0000678_abnormal_parathyroid_gland0.91070025
56MP0010329_abnormal_lipoprotein_level0.90427239
57MP0001879_abnormal_lymphatic_vessel0.89882960
58MP0002108_abnormal_muscle_morphology0.86792209
59MP0001958_emphysema0.86639840
60MP0005375_adipose_tissue_phenotype0.85265633
61MP0000427_abnormal_hair_cycle0.85022133
62MP0010234_abnormal_vibrissa_follicle0.84227349
63MP0002909_abnormal_adrenal_gland0.83847320
64MP0003646_muscle_fatigue0.83766539
65MP0009764_decreased_sensitivity_to0.83636118
66MP0004782_abnormal_surfactant_physiolog0.83419332
67MP0004085_abnormal_heartbeat0.83111650
68MP0005397_hematopoietic_system_phenotyp0.82345265
69MP0001545_abnormal_hematopoietic_system0.82345265
70MP0001501_abnormal_sleep_pattern0.80010847
71MP0004858_abnormal_nervous_system0.78208639
72MP0005551_abnormal_eye_electrophysiolog0.71780495
73MP0002295_abnormal_pulmonary_circulatio0.71073840
74MP0003091_abnormal_cell_migration0.70762966
75MP0002796_impaired_skin_barrier0.70452996
76MP0000613_abnormal_salivary_gland0.68962554
77MP0000627_abnormal_mammary_gland0.68534149
78MP0005365_abnormal_bile_salt0.67262897
79MP0001765_abnormal_ion_homeostasis0.66366153
80MP0001664_abnormal_digestion0.61979614
81MP0005187_abnormal_penis_morphology0.61165950
82MP0005595_abnormal_vascular_smooth0.59989900
83MP0010678_abnormal_skin_adnexa0.58931199
84MP0002638_abnormal_pupillary_reflex0.58321059
85MP0005452_abnormal_adipose_tissue0.58041299
86MP0000383_abnormal_hair_follicle0.58012077
87MP0010771_integument_phenotype0.57725991
88MP0002557_abnormal_social/conspecific_i0.57425921
89MP0001881_abnormal_mammary_gland0.56797019
90MP0005670_abnormal_white_adipose0.54272863
91MP0003879_abnormal_hair_cell0.54243518
92MP0002653_abnormal_ependyma_morphology0.53917454
93MP0002733_abnormal_thermal_nociception0.53138106
94MP0002128_abnormal_blood_circulation0.52491666
95MP0003252_abnormal_bile_duct0.52273861
96MP0003453_abnormal_keratinocyte_physiol0.52105125
97MP0005084_abnormal_gallbladder_morpholo0.51965078
98MP0008775_abnormal_heart_ventricle0.51757760
99MP0000538_abnormal_urinary_bladder0.50981315
100MP0002075_abnormal_coat/hair_pigmentati0.49402380

Predicted human phenotypes

RankGene SetZ-score
1Thyroid-stimulating hormone excess (HP:0002925)7.58411646
2Congenital ichthyosiform erythroderma (HP:0007431)5.96971026
3Upper limb muscle weakness (HP:0003484)5.43891128
4Hypergonadotropic hypogonadism (HP:0000815)5.28981448
5Decreased number of large peripheral myelinated nerve fibers (HP:0003387)5.10014438
6Capillary hemangiomas (HP:0005306)4.91280240
7Nonimmune hydrops fetalis (HP:0001790)4.54829929
8Abnormality of the aortic arch (HP:0012303)4.47430130
9Abnormal pupillary function (HP:0007686)4.43757181
10Abnormal auditory evoked potentials (HP:0006958)4.30768665
11Abnormality of glycolipid metabolism (HP:0010969)4.23401389
12Abnormality of liposaccharide metabolism (HP:0010968)4.23401389
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.23401389
14Tongue fasciculations (HP:0001308)3.89776335
15Muscle fibrillation (HP:0010546)3.86724459
16Accelerated skeletal maturation (HP:0005616)3.57795874
17Large for gestational age (HP:0001520)3.57491430
18Cardiovascular calcification (HP:0011915)3.50858168
19Volvulus (HP:0002580)3.43943398
20Pancreatic islet-cell hyperplasia (HP:0004510)3.39638618
21Vascular calcification (HP:0004934)3.10429743
22Poor head control (HP:0002421)2.97999053
23Mitral stenosis (HP:0001718)2.94078244
24Hyperpituitarism (HP:0010514)2.83312793
25Testicular neoplasm (HP:0010788)2.79310231
26Wormian bones (HP:0002645)2.78891321
27Female pseudohermaphroditism (HP:0010458)2.73543734
28Premature rupture of membranes (HP:0001788)2.71113217
29Flat cornea (HP:0007720)2.69128623
30Bilateral microphthalmos (HP:0007633)2.66738556
31Mesangial abnormality (HP:0001966)2.65640164
32Entropion (HP:0000621)2.62220395
33Aortic aneurysm (HP:0004942)2.61826399
34Venous insufficiency (HP:0005293)2.60906691
35Difficulty walking (HP:0002355)2.58243314
36Hydroxyprolinuria (HP:0003080)2.57943517
37Abnormality of proline metabolism (HP:0010907)2.57943517
38Oligodontia (HP:0000677)2.53814335
39Follicular hyperkeratosis (HP:0007502)2.53805046
40Hyperthyroidism (HP:0000836)2.53712466
41Abnormality of the ischium (HP:0003174)2.53240212
42Intestinal atresia (HP:0011100)2.52216387
43Broad alveolar ridges (HP:0000187)2.51455299
44Delayed gross motor development (HP:0002194)2.44845671
45Hypohidrosis (HP:0000966)2.43428540
46Long eyelashes (HP:0000527)2.40743764
47Onion bulb formation (HP:0003383)2.31327888
48Venous abnormality (HP:0002624)2.27833088
49Ectropion (HP:0000656)2.27662306
50Tubular atrophy (HP:0000092)2.25713112
51Back pain (HP:0003418)2.24289374
52Anosmia (HP:0000458)2.20470312
53Areflexia of lower limbs (HP:0002522)2.17169600
54Asymmetric septal hypertrophy (HP:0001670)2.09313132
55Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.08610206
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03018259
57Abnormality of polysaccharide metabolism (HP:0011012)2.03018259
58Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03018259
59Protrusio acetabuli (HP:0003179)2.02163043
60Striae distensae (HP:0001065)2.02059880
61Fragile skin (HP:0001030)2.00368267
62Basal cell carcinoma (HP:0002671)2.00233547
63Dysostosis multiplex (HP:0000943)1.99253180
64Aplasia of the musculature (HP:0100854)1.98608815
65Urinary glycosaminoglycan excretion (HP:0003541)1.98372190
66Mucopolysacchariduria (HP:0008155)1.98372190
67Amelogenesis imperfecta (HP:0000705)1.98157945
68Morphological abnormality of the middle ear (HP:0008609)1.98093941
69Bradycardia (HP:0001662)1.96318888
70Gynecomastia (HP:0000771)1.94578510
71Bilateral sensorineural hearing impairment (HP:0008619)1.93137867
72Distal lower limb muscle weakness (HP:0009053)1.92028644
73Osteolytic defects of the phalanges of the hand (HP:0009771)1.91837319
74Osteolytic defects of the hand bones (HP:0009699)1.91837319
75Thickened helices (HP:0000391)1.90606859
76Aortic dissection (HP:0002647)1.85657841
77Genu valgum (HP:0002857)1.85594831
78Blue sclerae (HP:0000592)1.84526016
79Abnormality of the pupil (HP:0000615)1.82366158
80Spondylolisthesis (HP:0003302)1.81770372
81Abnormality of endocrine pancreas physiology (HP:0012093)1.81576355
82Abnormality of the pancreatic islet cells (HP:0006476)1.81576355
83Muscular dystrophy (HP:0003560)1.80473691
84Enlarged penis (HP:0000040)1.77551158
85Hypoplasia of the iris (HP:0007676)1.73791621
86Reduced subcutaneous adipose tissue (HP:0003758)1.73188486
87Pseudobulbar signs (HP:0002200)1.72262118
88Acne (HP:0001061)1.69389608
89Flared iliac wings (HP:0002869)1.69289578
90Facial diplegia (HP:0001349)1.68366682
91Aortic valve stenosis (HP:0001650)1.66261141
92Breast hypoplasia (HP:0003187)1.65293092
93Hyporeflexia of lower limbs (HP:0002600)1.65118427
94Long nose (HP:0003189)1.64062291
95Abdominal distention (HP:0003270)1.61354266
96Aplasia/Hypoplasia of the tibia (HP:0005772)1.60865293
97Poikiloderma (HP:0001029)1.60662617
98Pili torti (HP:0003777)1.60290622
99Wide intermamillary distance (HP:0006610)1.59249361
100Severe Myopia (HP:0011003)1.58836619

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.15450113
2ADRBK24.95546440
3PDGFRA4.45137297
4AKT33.87632385
5FRK3.72468180
6EPHA23.24104044
7NME13.05592855
8MYLK2.74304418
9INSRR2.37376079
10NEK92.30985272
11DAPK22.23695070
12ERN12.15364116
13PINK11.85879254
14ADRBK11.85441961
15MET1.85177196
16PAK21.78883598
17PDGFRB1.73946799
18BLK1.69142189
19MAP3K121.62464353
20MST1R1.48166345
21LATS11.38040901
22ERBB41.35370161
23ICK1.26721517
24PRKCE1.25999707
25PKN11.24531077
26TRPM71.23515306
27RIPK11.22542889
28STK381.19945640
29TIE11.15504864
30MAPK111.13404704
31PIK3CG0.98971029
32PTK20.98175992
33MST40.95640264
34MAP2K10.95078233
35DAPK30.91893235
36DAPK10.91518736
37FLT30.86178309
38PTK2B0.82497589
39PRKCG0.82451877
40PDPK10.82275610
41IRAK30.78609177
42PRKD20.74596315
43MELK0.70723281
44LIMK10.69747870
45MAP3K70.68370620
46RPS6KB20.67699447
47TGFBR20.67123463
48STK38L0.65738202
49PLK20.65222730
50PAK60.63766115
51MAPKAPK30.63499592
52TESK10.62415226
53AKT20.62232610
54INSR0.61550495
55PDK20.59656276
56PRKAA20.59560771
57SRC0.58765699
58ABL20.58488285
59CAMK2G0.57914659
60EGFR0.56647003
61CAMK10.56592713
62BMPR1B0.56582959
63PNCK0.54084977
64RPS6KA20.52442545
65PRKG20.51980338
66PIM20.51839221
67MAP2K20.48892495
68CDC42BPA0.48229036
69FER0.46535215
70STK30.46425420
71MAPKAPK50.46349253
72ACVR1B0.44965573
73NTRK10.43570191
74EIF2AK30.43335926
75CAMK2A0.43177477
76TGFBR10.42853051
77GRK50.42665228
78GRK10.42587746
79PRKCI0.41138884
80PRKD10.39591543
81ROCK10.38958350
82PRKCA0.38853806
83PIK3CA0.37894980
84DDR20.36997930
85MAPK130.34535799
86MAP3K90.32385367
87TYRO30.31056872
88MAP3K30.29017974
89AURKB0.28806129
90BRSK10.28701990
91ZAP700.28460153
92RPS6KA60.28452786
93ERBB20.28176336
94EPHB20.27614005
95PDK10.26605944
96GRK70.25883025
97MTOR0.25076007
98IRAK10.22093351
99CAMK2B0.20305737
100CAMK2D0.18526652

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid hormone biosynthesis_Homo sapiens_hsa001407.53293656
2Ovarian steroidogenesis_Homo sapiens_hsa049137.46706369
3Sphingolipid metabolism_Homo sapiens_hsa006003.07952976
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.65665130
5Jak-STAT signaling pathway_Homo sapiens_hsa046302.61924724
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.56625231
7ECM-receptor interaction_Homo sapiens_hsa045122.14537718
8Dorso-ventral axis formation_Homo sapiens_hsa043202.12758905
9ABC transporters_Homo sapiens_hsa020101.78412090
10PI3K-Akt signaling pathway_Homo sapiens_hsa041511.62478120
11Mineral absorption_Homo sapiens_hsa049781.58147369
12N-Glycan biosynthesis_Homo sapiens_hsa005101.55193403
13Tryptophan metabolism_Homo sapiens_hsa003801.49315821
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49125953
15Renin-angiotensin system_Homo sapiens_hsa046141.48723602
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43007944
17Folate biosynthesis_Homo sapiens_hsa007901.32477518
18Salivary secretion_Homo sapiens_hsa049701.25957443
19Focal adhesion_Homo sapiens_hsa045101.21403296
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17399119
21Complement and coagulation cascades_Homo sapiens_hsa046101.16878172
22Histidine metabolism_Homo sapiens_hsa003401.14041900
23Olfactory transduction_Homo sapiens_hsa047401.12493381
24Lysosome_Homo sapiens_hsa041421.10996192
25Other glycan degradation_Homo sapiens_hsa005111.09420170
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08831395
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07823967
28Inositol phosphate metabolism_Homo sapiens_hsa005621.06807695
29Primary bile acid biosynthesis_Homo sapiens_hsa001200.93753767
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93149214
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86420369
32Cyanoamino acid metabolism_Homo sapiens_hsa004600.86350848
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85586940
34Retinol metabolism_Homo sapiens_hsa008300.84340449
35Chemical carcinogenesis_Homo sapiens_hsa052040.83194081
36Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82884310
37Vitamin digestion and absorption_Homo sapiens_hsa049770.81924187
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76340833
39Arachidonic acid metabolism_Homo sapiens_hsa005900.76040500
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75088065
41Prolactin signaling pathway_Homo sapiens_hsa049170.75079204
42Glycerolipid metabolism_Homo sapiens_hsa005610.74211060
43Linoleic acid metabolism_Homo sapiens_hsa005910.71914173
44Morphine addiction_Homo sapiens_hsa050320.70668331
45Fanconi anemia pathway_Homo sapiens_hsa034600.65709052
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63415885
47Ras signaling pathway_Homo sapiens_hsa040140.62448492
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61125156
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.60111948
50Axon guidance_Homo sapiens_hsa043600.60072662
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59493313
52Sulfur relay system_Homo sapiens_hsa041220.57500994
53Protein digestion and absorption_Homo sapiens_hsa049740.57487137
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56067951
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55943388
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55291801
57Metabolic pathways_Homo sapiens_hsa011000.54855402
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52858174
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52245558
60Tight junction_Homo sapiens_hsa045300.50175777
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.47972880
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46680698
63Starch and sucrose metabolism_Homo sapiens_hsa005000.45933086
64Galactose metabolism_Homo sapiens_hsa000520.44476744
65Phototransduction_Homo sapiens_hsa047440.43986975
66Proteoglycans in cancer_Homo sapiens_hsa052050.43869480
67Bladder cancer_Homo sapiens_hsa052190.42533249
68Bile secretion_Homo sapiens_hsa049760.41751449
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41606886
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40763207
71Dilated cardiomyopathy_Homo sapiens_hsa054140.40602932
72Hippo signaling pathway_Homo sapiens_hsa043900.40252840
73Pentose phosphate pathway_Homo sapiens_hsa000300.40194886
74Rap1 signaling pathway_Homo sapiens_hsa040150.39014523
75Platelet activation_Homo sapiens_hsa046110.38051630
76Arginine and proline metabolism_Homo sapiens_hsa003300.38040300
77Calcium signaling pathway_Homo sapiens_hsa040200.37157212
78Taste transduction_Homo sapiens_hsa047420.36646178
79Caffeine metabolism_Homo sapiens_hsa002320.36627406
80Glutathione metabolism_Homo sapiens_hsa004800.36228519
81Fatty acid biosynthesis_Homo sapiens_hsa000610.35762354
82Thyroid hormone synthesis_Homo sapiens_hsa049180.35170971
83TGF-beta signaling pathway_Homo sapiens_hsa043500.35107520
84Small cell lung cancer_Homo sapiens_hsa052220.34692688
85Estrogen signaling pathway_Homo sapiens_hsa049150.34442601
86PPAR signaling pathway_Homo sapiens_hsa033200.31216838
87Homologous recombination_Homo sapiens_hsa034400.29140903
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28380980
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.27696335
90Endocytosis_Homo sapiens_hsa041440.25487878
91Amoebiasis_Homo sapiens_hsa051460.24894417
92Pathways in cancer_Homo sapiens_hsa052000.24425951
93Ether lipid metabolism_Homo sapiens_hsa005650.24337635
94Malaria_Homo sapiens_hsa051440.23778977
95Insulin resistance_Homo sapiens_hsa049310.23583123
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23040433
97Melanoma_Homo sapiens_hsa052180.22209946
98Tyrosine metabolism_Homo sapiens_hsa003500.21367500
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.17966828
100MicroRNAs in cancer_Homo sapiens_hsa052060.17928962

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »