PSMA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.49247506
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.41957749
3maturation of SSU-rRNA (GO:0030490)5.15704445
4ATP synthesis coupled proton transport (GO:0015986)4.98704036
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.98704036
6viral transcription (GO:0019083)4.96508446
7ribosomal small subunit assembly (GO:0000028)4.95469634
8ribosomal small subunit biogenesis (GO:0042274)4.93634306
9translational termination (GO:0006415)4.88227745
10* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.83493567
11DNA deamination (GO:0045006)4.66773444
12ribosomal large subunit biogenesis (GO:0042273)4.60890874
13* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.57458036
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.52215325
15cotranslational protein targeting to membrane (GO:0006613)4.50415242
16* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.45564731
17protein targeting to ER (GO:0045047)4.44324403
18* regulation of cellular amino acid metabolic process (GO:0006521)4.44049746
19* negative regulation of ligase activity (GO:0051352)4.41499749
20* negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.41499749
21* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.38158957
22* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.32855066
23translational elongation (GO:0006414)4.26657005
24* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.26026850
25* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.26026850
26* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.25443634
27protein localization to endoplasmic reticulum (GO:0070972)4.25332020
28formation of translation preinitiation complex (GO:0001731)4.22740738
29* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.22337974
30* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.22337974
31* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.22337974
32establishment of protein localization to endoplasmic reticulum (GO:0072599)4.21568520
33translational initiation (GO:0006413)4.15090937
34* signal transduction involved in DNA integrity checkpoint (GO:0072401)4.12996506
35* signal transduction involved in DNA damage checkpoint (GO:0072422)4.12996506
36protein neddylation (GO:0045116)4.09915657
37* signal transduction involved in cell cycle checkpoint (GO:0072395)4.07051780
387-methylguanosine mRNA capping (GO:0006370)4.05757551
39transcription elongation from RNA polymerase III promoter (GO:0006385)4.05110896
40termination of RNA polymerase III transcription (GO:0006386)4.05110896
41* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)4.01339440
42establishment of integrated proviral latency (GO:0075713)4.00792272
43translation (GO:0006412)4.00304301
44RNA capping (GO:0036260)3.99466379
457-methylguanosine RNA capping (GO:0009452)3.99466379
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.97340524
47cullin deneddylation (GO:0010388)3.97082776
48* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.95168352
49viral life cycle (GO:0019058)3.92376286
50ribonucleoprotein complex biogenesis (GO:0022613)3.88781649
51cellular protein complex disassembly (GO:0043624)3.88569939
52protein deneddylation (GO:0000338)3.83550850
53* positive regulation of ligase activity (GO:0051351)3.80727281
54nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.77692138
55chaperone-mediated protein transport (GO:0072321)3.76610495
56histone exchange (GO:0043486)3.72871014
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.71023442
58DNA strand elongation involved in DNA replication (GO:0006271)3.69232250
59spliceosomal snRNP assembly (GO:0000387)3.66608522
60DNA double-strand break processing (GO:0000729)3.62846741
61rRNA modification (GO:0000154)3.60992252
62telomere maintenance via semi-conservative replication (GO:0032201)3.59211221
63regulation of mitochondrial translation (GO:0070129)3.58406828
64mitotic metaphase plate congression (GO:0007080)3.57554862
65L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.57232170
66rRNA processing (GO:0006364)3.56313594
67transcription elongation from RNA polymerase I promoter (GO:0006362)3.55606852
68mitochondrial respiratory chain complex I assembly (GO:0032981)3.54707104
69NADH dehydrogenase complex assembly (GO:0010257)3.54707104
70mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.54707104
71respiratory electron transport chain (GO:0022904)3.52684124
72protein complex biogenesis (GO:0070271)3.52419697
73ribosome assembly (GO:0042255)3.51008750
74mitochondrial respiratory chain complex assembly (GO:0033108)3.50888682
75CENP-A containing nucleosome assembly (GO:0034080)3.50834383
76cellular component biogenesis (GO:0044085)3.49957206
77DNA strand elongation (GO:0022616)3.49332887
78DNA replication-independent nucleosome organization (GO:0034724)3.49034360
79DNA replication-independent nucleosome assembly (GO:0006336)3.49034360
80establishment of viral latency (GO:0019043)3.48135193
81DNA replication checkpoint (GO:0000076)3.46355541
82* regulation of ubiquitin-protein transferase activity (GO:0051438)3.46105936
83termination of RNA polymerase I transcription (GO:0006363)3.44368610
84transcription-coupled nucleotide-excision repair (GO:0006283)3.44069111
85electron transport chain (GO:0022900)3.44019535
86rRNA metabolic process (GO:0016072)3.41440822
87nucleobase biosynthetic process (GO:0046112)3.39446544
88purine nucleobase biosynthetic process (GO:0009113)3.38908233
89* positive regulation of cell cycle arrest (GO:0071158)3.38506857
90DNA replication initiation (GO:0006270)3.38142151
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.38088062
92exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.36745660
93* DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.36682682
94* regulation of ligase activity (GO:0051340)3.36201715
95chromatin remodeling at centromere (GO:0031055)3.34444114
96establishment of protein localization to mitochondrion (GO:0072655)3.31290637
97transcription from RNA polymerase I promoter (GO:0006360)3.31169771
98* negative regulation of protein ubiquitination (GO:0031397)3.30510189
99DNA catabolic process, exonucleolytic (GO:0000738)3.30306440
100* regulation of cellular amine metabolic process (GO:0033238)3.30271704
101spliceosomal complex assembly (GO:0000245)3.30222748
102pseudouridine synthesis (GO:0001522)3.30093905
103* cell cycle G1/S phase transition (GO:0044843)3.29197554
104* G1/S transition of mitotic cell cycle (GO:0000082)3.29197554
105protein targeting to mitochondrion (GO:0006626)3.29070461
106protein complex disassembly (GO:0043241)3.28609471
107respiratory chain complex IV assembly (GO:0008535)3.26376650
108* antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.26090122
109deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.26006714
110telomere maintenance via recombination (GO:0000722)3.25905550
111oxidative phosphorylation (GO:0006119)3.25730998
112DNA damage response, detection of DNA damage (GO:0042769)3.25664033
113regulation of mitotic spindle checkpoint (GO:1903504)3.25226203
114regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.25226203
115ribosome biogenesis (GO:0042254)3.24464860
116DNA ligation (GO:0006266)3.24311044
117IMP biosynthetic process (GO:0006188)3.21618075
118histone mRNA metabolic process (GO:0008334)3.19459414
119RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.19104440
120tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.19104440
121protein localization to kinetochore (GO:0034501)3.17197292
122protein localization to mitochondrion (GO:0070585)3.16170371
123mitotic recombination (GO:0006312)3.15603707
124metaphase plate congression (GO:0051310)3.13970699
125nucleotide-excision repair, DNA gap filling (GO:0006297)3.09740159
126kinetochore organization (GO:0051383)3.09294001
127* negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.07625895
128rRNA methylation (GO:0031167)3.07313877
129spindle checkpoint (GO:0031577)3.05229893
130negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04217297
131negative regulation of mitotic sister chromatid segregation (GO:0033048)3.04217297
132negative regulation of mitotic sister chromatid separation (GO:2000816)3.04217297
133negative regulation of sister chromatid segregation (GO:0033046)3.04217297
134negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.04217297
135kinetochore assembly (GO:0051382)3.03863777

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.10305451
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.81788363
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.58180238
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.47463845
5* EST1_17652178_ChIP-ChIP_JURKAT_Human4.21161717
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.97515443
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.84434503
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.67400188
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.60728379
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.60543581
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.46205522
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.24666568
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.18885245
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.12494671
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.06613220
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93931033
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93460639
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81591338
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.81120794
20VDR_23849224_ChIP-Seq_CD4+_Human2.78801370
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62364275
22XRN2_22483619_ChIP-Seq_HELA_Human2.47587110
23* DCP1A_22483619_ChIP-Seq_HELA_Human2.45621526
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.42815511
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39797134
26ELK1_19687146_ChIP-ChIP_HELA_Human2.38970398
27* CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.38946512
28* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29169982
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.20725085
30FOXP3_21729870_ChIP-Seq_TREG_Human2.20516963
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11129159
32* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.10968778
33GABP_19822575_ChIP-Seq_HepG2_Human2.10898175
34TTF2_22483619_ChIP-Seq_HELA_Human2.07242443
35* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92961426
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.92174490
37* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80099218
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78878129
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78319029
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77175048
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76936875
42* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74046138
43AR_21909140_ChIP-Seq_LNCAP_Human1.66556401
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65274509
45* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62432577
46ELK1_22589737_ChIP-Seq_MCF10A_Human1.60508436
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.58302199
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57966302
49* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54881118
50* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46104551
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45516164
52* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41641043
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41363478
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40808534
55* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38632103
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33729775
57MYC_18940864_ChIP-ChIP_HL60_Human1.33124563
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32629503
59* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32041546
60EWS_26573619_Chip-Seq_HEK293_Human1.28555578
61* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25191179
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.24487569
63CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.17874616
64VDR_22108803_ChIP-Seq_LS180_Human1.17812931
65KDM5A_27292631_Chip-Seq_BREAST_Human1.15258834
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13092515
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12092090
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11523965
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10830596
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08786627
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08619286
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06813289
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06667537
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.04793129
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.01699164
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.00901373
77SOX17_20123909_ChIP-Seq_XEN_Mouse1.00753161
78ZNF274_21170338_ChIP-Seq_K562_Hela1.00184136
79TFEB_21752829_ChIP-Seq_HELA_Human0.97434274
80* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97196557
81FUS_26573619_Chip-Seq_HEK293_Human0.96500434
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93674507
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93115157
84IRF1_19129219_ChIP-ChIP_H3396_Human0.93041650
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92884338
86SPI1_23547873_ChIP-Seq_NB4_Human0.89727602
87RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89317541
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89265174
89NOTCH1_21737748_ChIP-Seq_TLL_Human0.88971018
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87263297
91* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.86997750
92* CIITA_25753668_ChIP-Seq_RAJI_Human0.85272582
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82942687
94SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82877073
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82773655
96OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82202317
97STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81459574
98SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80162958
99KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79306264
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78160369
101ELF5_23300383_ChIP-Seq_T47D_Human0.77647130
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76390898
103* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.75803118
104NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73640540
105SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.72499196
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.71782042
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.70883217
108CTCF_18555785_ChIP-Seq_MESCs_Mouse0.70696552
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.69773936
110PCGF2_27294783_Chip-Seq_ESCs_Mouse0.69767496
111TP53_22573176_ChIP-Seq_HFKS_Human0.66455086
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.65892919
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.65356852
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.65096013
115ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.64842895
116NANOG_16153702_ChIP-ChIP_HESCs_Human0.64237218
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.64075728
118CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.63593166
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.63156899

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.36346819
2MP0004957_abnormal_blastocyst_morpholog4.67838238
3MP0010094_abnormal_chromosome_stability3.69649848
4MP0003077_abnormal_cell_cycle3.48178216
5MP0008057_abnormal_DNA_replication3.33149483
6MP0003111_abnormal_nucleus_morphology3.28571939
7MP0008058_abnormal_DNA_repair3.24891789
8MP0008932_abnormal_embryonic_tissue3.18368605
9MP0009379_abnormal_foot_pigmentation3.12343325
10MP0003806_abnormal_nucleotide_metabolis3.01412413
11MP0003718_maternal_effect2.93341675
12MP0003941_abnormal_skin_development2.64110886
13MP0003186_abnormal_redox_activity2.56101151
14MP0001529_abnormal_vocalization2.41613967
15MP0003786_premature_aging2.40111819
16MP0008007_abnormal_cellular_replicative2.36354038
17MP0003123_paternal_imprinting2.08461097
18MP0008877_abnormal_DNA_methylation2.00675289
19MP0003890_abnormal_embryonic-extraembry1.80816261
20MP0006036_abnormal_mitochondrial_physio1.80483308
21MP0001730_embryonic_growth_arrest1.75990739
22MP0009333_abnormal_splenocyte_physiolog1.75879520
23MP0001905_abnormal_dopamine_level1.69000114
24MP0003315_abnormal_perineum_morphology1.58582838
25MP0006035_abnormal_mitochondrial_morpho1.57891530
26MP0003136_yellow_coat_color1.52850600
27MP0000350_abnormal_cell_proliferation1.52122431
28MP0002638_abnormal_pupillary_reflex1.47151524
29MP0005408_hypopigmentation1.41327916
30MP0002938_white_spotting1.40798892
31MP0008260_abnormal_autophagy1.40764162
32MP0006292_abnormal_olfactory_placode1.38899549
33MP0002132_abnormal_respiratory_system1.36931697
34MP0002148_abnormal_hypersensitivity_rea1.35598423
35MP0000490_abnormal_crypts_of1.27675044
36MP0002254_reproductive_system_inflammat1.25789060
37MP0002163_abnormal_gland_morphology1.25494446
38MP0000372_irregular_coat_pigmentation1.24835605
39MP0008875_abnormal_xenobiotic_pharmacok1.23194551
40MP0002736_abnormal_nociception_after1.22757942
41MP0000313_abnormal_cell_death1.20222748
42MP0005084_abnormal_gallbladder_morpholo1.19669042
43MP0005394_taste/olfaction_phenotype1.19052178
44MP0005499_abnormal_olfactory_system1.19052178
45MP0009785_altered_susceptibility_to1.17280163
46MP0001727_abnormal_embryo_implantation1.16626195
47MP0001697_abnormal_embryo_size1.12135800
48MP0001986_abnormal_taste_sensitivity1.10912065
49MP0001853_heart_inflammation1.10895872
50MP0005671_abnormal_response_to1.10737671
51MP0003763_abnormal_thymus_physiology1.09717360
52MP0009697_abnormal_copulation1.09195200
53MP0010030_abnormal_orbit_morphology1.08767576
54MP0002019_abnormal_tumor_incidence1.07908046
55MP0002080_prenatal_lethality1.05899531
56MP0002090_abnormal_vision1.05426150
57MP0003195_calcinosis1.05164786
58MP0002160_abnormal_reproductive_system1.05114358
59MP0002102_abnormal_ear_morphology1.04686641
60MP0003724_increased_susceptibility_to1.03165934
61MP0001542_abnormal_bone_strength1.03075568
62MP0008789_abnormal_olfactory_epithelium1.02935556
63MP0000358_abnormal_cell_content/1.02565264
64MP0003567_abnormal_fetal_cardiomyocyte1.02091564
65MP0004133_heterotaxia1.00585788
66MP0003937_abnormal_limbs/digits/tail_de1.00437896
67MP0005389_reproductive_system_phenotype0.98055307
68MP0002210_abnormal_sex_determination0.97283574
69MP0004215_abnormal_myocardial_fiber0.95423642
70MP0008995_early_reproductive_senescence0.94695702
71MP0001835_abnormal_antigen_presentation0.94548622
72MP0002396_abnormal_hematopoietic_system0.92434922
73MP0000566_synostosis0.92055841
74MP0000647_abnormal_sebaceous_gland0.91810162
75MP0005253_abnormal_eye_physiology0.91396601
76MP0008872_abnormal_physiological_respon0.91202789
77MP0003011_delayed_dark_adaptation0.90321215
78MP0002084_abnormal_developmental_patter0.90111733
79MP0005395_other_phenotype0.89826139
80MP0002722_abnormal_immune_system0.89307373
81MP0002751_abnormal_autonomic_nervous0.89147751
82MP0004381_abnormal_hair_follicle0.88718643
83MP0001286_abnormal_eye_development0.88072692
84MP0004147_increased_porphyrin_level0.87960724
85MP0005075_abnormal_melanosome_morpholog0.86990331
86MP0001188_hyperpigmentation0.86844173
87MP0000689_abnormal_spleen_morphology0.86787470
88MP0002398_abnormal_bone_marrow0.85730375
89MP0001984_abnormal_olfaction0.84486840
90MP0002277_abnormal_respiratory_mucosa0.84125025
91MP0001881_abnormal_mammary_gland0.82783094
92MP0002233_abnormal_nose_morphology0.82771539
93MP0002837_dystrophic_cardiac_calcinosis0.82460306
94MP0006054_spinal_hemorrhage0.82448685
95MP0001672_abnormal_embryogenesis/_devel0.80385148
96MP0005380_embryogenesis_phenotype0.80385148
97MP0001145_abnormal_male_reproductive0.80334021
98MP0000703_abnormal_thymus_morphology0.79810582
99MP0002429_abnormal_blood_cell0.79609039
100MP0009672_abnormal_birth_weight0.77973480
101MP0005000_abnormal_immune_tolerance0.77868839
102MP0002085_abnormal_embryonic_tissue0.77577480
103MP0005332_abnormal_amino_acid0.75831085
104MP0005025_abnormal_response_to0.73970616
105MP0002420_abnormal_adaptive_immunity0.73254652
106MP0003119_abnormal_digestive_system0.72993619
107MP0000716_abnormal_immune_system0.72210180
108MP0001819_abnormal_immune_cell0.72073736
109MP0000653_abnormal_sex_gland0.71349186
110MP0001764_abnormal_homeostasis0.68544018
111MP0001919_abnormal_reproductive_system0.68422556
112MP0001485_abnormal_pinna_reflex0.68311476
113MP0001929_abnormal_gametogenesis0.68106506
114MP0002723_abnormal_immune_serum0.67910858
115MP0002111_abnormal_tail_morphology0.67880482
116MP0000858_altered_metastatic_potential0.67314051
117MP0006276_abnormal_autonomic_nervous0.67310003
118MP0005266_abnormal_metabolism0.67202592
119MP0003121_genomic_imprinting0.66088383
120MP0010307_abnormal_tumor_latency0.65865855
121MP0003221_abnormal_cardiomyocyte_apopto0.65787031
122MP0003984_embryonic_growth_retardation0.65393407
123MP0001119_abnormal_female_reproductive0.65129184
124MP0002452_abnormal_antigen_presenting0.63763110
125MP0006072_abnormal_retinal_apoptosis0.63730777
126MP0001293_anophthalmia0.63650940
127MP0008873_increased_physiological_sensi0.63241200
128MP0005410_abnormal_fertilization0.62481536
129MP0002405_respiratory_system_inflammati0.61765750
130MP0002088_abnormal_embryonic_growth/wei0.60713350
131MP0010386_abnormal_urinary_bladder0.60643012
132MP0004142_abnormal_muscle_tone0.58992458
133MP0005636_abnormal_mineral_homeostasis0.57877597
134MP0000049_abnormal_middle_ear0.56569426
135MP0003950_abnormal_plasma_membrane0.54248484
136MP0005551_abnormal_eye_electrophysiolog0.53157926

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.47573081
2Mitochondrial inheritance (HP:0001427)4.94526466
3Abnormal mitochondria in muscle tissue (HP:0008316)4.88951001
4Abnormality of cells of the erythroid lineage (HP:0012130)4.84601633
5Increased hepatocellular lipid droplets (HP:0006565)4.42571808
6Abnormal number of erythroid precursors (HP:0012131)4.41021784
7Progressive macrocephaly (HP:0004481)4.40377753
8Increased CSF lactate (HP:0002490)4.39405932
9Birth length less than 3rd percentile (HP:0003561)4.30553876
10Acute encephalopathy (HP:0006846)4.28484789
11Hepatocellular necrosis (HP:0001404)4.26423607
12Reticulocytopenia (HP:0001896)4.19066463
13Increased serum pyruvate (HP:0003542)4.04297286
14Abnormality of glycolysis (HP:0004366)4.04297286
15Lipid accumulation in hepatocytes (HP:0006561)3.88700612
16Hepatic necrosis (HP:0002605)3.70681462
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.67633312
18Macrocytic anemia (HP:0001972)3.66070031
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.64796047
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.64796047
21Breast hypoplasia (HP:0003187)3.63219275
22Cerebral hypomyelination (HP:0006808)3.54476407
233-Methylglutaconic aciduria (HP:0003535)3.53610822
24Renal Fanconi syndrome (HP:0001994)3.49517659
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.40648019
26Increased serum lactate (HP:0002151)3.40177373
27Exertional dyspnea (HP:0002875)3.27371305
28Abnormality of methionine metabolism (HP:0010901)3.14800679
29Exercise intolerance (HP:0003546)3.11821838
30Respiratory failure (HP:0002878)3.05216931
31Pallor (HP:0000980)3.01300929
32Rough bone trabeculation (HP:0100670)3.00526791
33Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.97752076
34Oral leukoplakia (HP:0002745)2.95647766
35Methylmalonic acidemia (HP:0002912)2.87380903
36Cerebral edema (HP:0002181)2.87098669
37Increased intramyocellular lipid droplets (HP:0012240)2.86262251
38Lactic acidosis (HP:0003128)2.85114683
39Abnormality of aspartate family amino acid metabolism (HP:0010899)2.84388608
40Abnormality of the labia minora (HP:0012880)2.78917426
41Leukodystrophy (HP:0002415)2.75538264
42Carpal bone hypoplasia (HP:0001498)2.75245429
43Aplastic anemia (HP:0001915)2.73514603
44Respiratory difficulties (HP:0002880)2.71165577
45Type I transferrin isoform profile (HP:0003642)2.68325702
46Reduced antithrombin III activity (HP:0001976)2.66888480
47Methylmalonic aciduria (HP:0012120)2.64919064
48Abnormality of the ileum (HP:0001549)2.62748531
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.58845270
50Multiple enchondromatosis (HP:0005701)2.57181218
51Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55900416
52Parakeratosis (HP:0001036)2.54735830
53Abnormality of serum amino acid levels (HP:0003112)2.52821435
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.51086740
55Abnormality of chromosome stability (HP:0003220)2.50296529
56Poor head control (HP:0002421)2.50295725
57Abnormality of the anterior horn cell (HP:0006802)2.48139515
58Degeneration of anterior horn cells (HP:0002398)2.48139515
59Lethargy (HP:0001254)2.47778728
60Chromsome breakage (HP:0040012)2.47450877
61Optic disc pallor (HP:0000543)2.40625499
62Abnormal lung lobation (HP:0002101)2.40022567
63Stenosis of the external auditory canal (HP:0000402)2.38593855
64Microretrognathia (HP:0000308)2.35725956
65Microvesicular hepatic steatosis (HP:0001414)2.34373683
66Abnormal trabecular bone morphology (HP:0100671)2.33380995
67Secondary amenorrhea (HP:0000869)2.32429958
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27846342
69Abnormality of alanine metabolism (HP:0010916)2.27846342
70Hyperalaninemia (HP:0003348)2.27846342
71Increased muscle lipid content (HP:0009058)2.27146528
72Congenital ichthyosiform erythroderma (HP:0007431)2.26374310
73CNS demyelination (HP:0007305)2.25405997
74Trismus (HP:0000211)2.25024164
75Premature graying of hair (HP:0002216)2.24751040
76Megaloblastic anemia (HP:0001889)2.23690854
77CNS hypomyelination (HP:0003429)2.18407612
78Abnormality of renal resorption (HP:0011038)2.15165192
79Hyperglycinemia (HP:0002154)2.13484668
80Aplasia/hypoplasia of the uterus (HP:0008684)2.12595883
81Emotional lability (HP:0000712)2.12436141
82Patellar aplasia (HP:0006443)2.12087166
83Generalized aminoaciduria (HP:0002909)2.10786807
84Cleft eyelid (HP:0000625)2.10110025
85Absent radius (HP:0003974)2.07327478
86IgM deficiency (HP:0002850)2.05247918
87Duodenal stenosis (HP:0100867)2.04843790
88Small intestinal stenosis (HP:0012848)2.04843790
89Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.04230123
90Cellular immunodeficiency (HP:0005374)2.03346988
91Aplasia/Hypoplasia of the patella (HP:0006498)2.02961306
92Delusions (HP:0000746)2.01719574
93Postnatal microcephaly (HP:0005484)2.00267672
94Septo-optic dysplasia (HP:0100842)1.99801165
95Glossoptosis (HP:0000162)1.99278291
96Horseshoe kidney (HP:0000085)1.97856289
97Absent forearm bone (HP:0003953)1.94972977
98Aplasia involving forearm bones (HP:0009822)1.94972977
99Pancytopenia (HP:0001876)1.92407579
100Premature ovarian failure (HP:0008209)1.92350212
101Abnormality of placental membranes (HP:0011409)1.91716083
102Amniotic constriction ring (HP:0009775)1.91716083
103Sparse eyelashes (HP:0000653)1.91511053
104Glycosuria (HP:0003076)1.89224676
105Abnormality of urine glucose concentration (HP:0011016)1.89224676
106Absent thumb (HP:0009777)1.89133434
107Congenital, generalized hypertrichosis (HP:0004540)1.87288793
108Abnormality of the vitamin B12 metabolism (HP:0004341)1.84779478
109Abnormality of the preputium (HP:0100587)1.84184413
110Abnormality of the duodenum (HP:0002246)1.84178144
111X-linked dominant inheritance (HP:0001423)1.83371413
112Abnormal protein glycosylation (HP:0012346)1.83001349
113Abnormal glycosylation (HP:0012345)1.83001349
114Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83001349
115Abnormal protein N-linked glycosylation (HP:0012347)1.83001349
116Irregular epiphyses (HP:0010582)1.82386850
117Abnormality of sulfur amino acid metabolism (HP:0004339)1.82358029
118Neoplasm of the adrenal gland (HP:0100631)1.81962705
119Median cleft lip (HP:0000161)1.80503068
120Aplasia/Hypoplasia involving the musculature (HP:0001460)1.78489266
121Triphalangeal thumb (HP:0001199)1.77773748
122Absent septum pellucidum (HP:0001331)1.77725870
123Neoplasm of the colon (HP:0100273)1.77418182
124Type 2 muscle fiber atrophy (HP:0003554)1.75704542
125Abnormality of vitamin B metabolism (HP:0004340)1.74838421
126Abnormality of glycine metabolism (HP:0010895)1.73514876
127Abnormality of serine family amino acid metabolism (HP:0010894)1.73514876
128Meckel diverticulum (HP:0002245)1.72799302
129Pancreatic cysts (HP:0001737)1.71256138
130Muscle fiber atrophy (HP:0100295)1.69733788
131Agnosia (HP:0010524)1.69310931
132Colon cancer (HP:0003003)1.68725252
133Hypoplasia of the capital femoral epiphysis (HP:0003090)1.68664487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.98065522
2EIF2AK13.81821828
3VRK23.75645222
4STK163.65691288
5WEE13.64424583
6NME23.42802207
7PBK3.11839009
8SRPK12.63726255
9EIF2AK32.58444785
10MST42.35267857
11TESK22.34235890
12VRK12.30123131
13TRIM282.28656263
14NME12.24400140
15CDC72.07989143
16PLK42.06395423
17TSSK61.99546835
18PIM21.89571368
19TLK11.89501816
20ACVR1B1.71598502
21ARAF1.70441263
22NUAK11.65491623
23KDR1.61871463
24TNIK1.49356624
25LIMK11.44334216
26MKNK11.40812588
27BRSK21.34561802
28PNCK1.33392329
29MAP3K121.32842757
30PLK31.30268173
31PLK11.30169679
32MAP4K21.28277155
33TESK11.25445157
34AURKA1.24230598
35DYRK31.21372189
36DYRK21.21371653
37BRAF1.20794872
38TAF11.18888798
39AURKB1.17069031
40TTK1.13660053
41PDK21.13284204
42BCR1.06148898
43EPHA21.04209171
44RPS6KB20.96346397
45ZAK0.93061742
46ABL20.91734634
47BMPR20.89903999
48CDK190.89534401
49EIF2AK20.88806315
50PASK0.88458041
51CDK70.87672997
52MKNK20.87486680
53CSNK1G20.77723062
54CSNK2A10.75926102
55BMPR1B0.75384909
56NEK10.75146471
57PAK10.74352599
58CDK80.74042282
59CSNK2A20.71752182
60BLK0.71531588
61CHEK20.71243457
62DAPK10.71209274
63RPS6KA50.71181086
64ATR0.70828930
65CCNB10.70776239
66CSNK1A1L0.70071458
67MYLK0.68765553
68ILK0.68268656
69BRSK10.67823911
70NEK20.66901289
71CSNK1G30.66079220
72SCYL20.65679469
73MAP3K110.64367363
74STK38L0.63698858
75RPS6KA40.63176170
76LRRK20.61702412
77ERBB30.60655514
78IRAK40.58816723
79MAP3K80.58699941
80GRK10.58352206
81STK240.57645882
82ERBB40.57515790
83PAK40.57061577
84STK40.55206664
85FLT30.55018381
86PIK3CG0.53797010
87TXK0.53510737
88ALK0.50731041
89ADRBK20.48869087
90BCKDK0.47775838
91GRK70.46618277
92PRKCI0.46333702
93CHEK10.45404112
94STK100.42652488
95MAPKAPK30.41308159
96STK390.40436476
97TGFBR10.40314874
98CLK10.40304672
99OXSR10.39257581
100STK30.39168342
101TEC0.36917558
102MOS0.36800274
103MAP2K70.36544303
104LYN0.35061999
105PIM10.34614553
106YES10.33691547
107SIK30.33307024
108DAPK30.32406093
109CSNK1G10.29779807
110NLK0.28807179
111INSRR0.28656093
112MUSK0.27452961
113CSNK1E0.27450464
114TIE10.27217165
115WNK30.27016829
116RAF10.26942066
117IKBKB0.26749813
118CDK140.26178951
119PLK20.25652383
120MAP3K40.25208051
121IRAK30.24865062
122MAP3K30.24791680
123ATM0.24332235
124MINK10.23612474
125NEK60.23211252
126CDK20.23169946
127CDK10.22849768

Predicted pathways (KEGG)

RankGene SetZ-score
1* Proteasome_Homo sapiens_hsa030505.54208014
2Ribosome_Homo sapiens_hsa030104.77670099
3RNA polymerase_Homo sapiens_hsa030203.87525057
4DNA replication_Homo sapiens_hsa030303.42436402
5Oxidative phosphorylation_Homo sapiens_hsa001903.40143300
6Mismatch repair_Homo sapiens_hsa034302.99309111
7Parkinsons disease_Homo sapiens_hsa050122.98019577
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97665183
9Spliceosome_Homo sapiens_hsa030402.73911507
10Protein export_Homo sapiens_hsa030602.68539497
11Pyrimidine metabolism_Homo sapiens_hsa002402.49839974
12Nucleotide excision repair_Homo sapiens_hsa034202.41628923
13Huntingtons disease_Homo sapiens_hsa050162.32167460
14Homologous recombination_Homo sapiens_hsa034402.29609256
15RNA transport_Homo sapiens_hsa030132.20819828
16Base excision repair_Homo sapiens_hsa034102.03229285
17Alzheimers disease_Homo sapiens_hsa050101.99053158
18Basal transcription factors_Homo sapiens_hsa030221.98691469
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.72106763
20Non-homologous end-joining_Homo sapiens_hsa034501.63968665
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63408037
22RNA degradation_Homo sapiens_hsa030181.58267690
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56671339
24Cell cycle_Homo sapiens_hsa041101.54633574
25Propanoate metabolism_Homo sapiens_hsa006401.53506656
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50860775
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38132551
28Purine metabolism_Homo sapiens_hsa002301.37385494
29Fanconi anemia pathway_Homo sapiens_hsa034601.32064254
30One carbon pool by folate_Homo sapiens_hsa006701.28966376
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24487603
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20021277
33Folate biosynthesis_Homo sapiens_hsa007901.19248582
34Epstein-Barr virus infection_Homo sapiens_hsa051691.09005156
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07255923
36Glutathione metabolism_Homo sapiens_hsa004800.93636168
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92700067
38p53 signaling pathway_Homo sapiens_hsa041150.91986348
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90224528
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84791475
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82444215
42Pentose phosphate pathway_Homo sapiens_hsa000300.75555452
43Cardiac muscle contraction_Homo sapiens_hsa042600.74226209
44Systemic lupus erythematosus_Homo sapiens_hsa053220.72926621
45Selenocompound metabolism_Homo sapiens_hsa004500.72507319
46Peroxisome_Homo sapiens_hsa041460.71206168
47Graft-versus-host disease_Homo sapiens_hsa053320.70824606
48mRNA surveillance pathway_Homo sapiens_hsa030150.70756963
49Steroid biosynthesis_Homo sapiens_hsa001000.69397351
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67983377
51Fatty acid elongation_Homo sapiens_hsa000620.65837707
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.65206757
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63721705
54Vibrio cholerae infection_Homo sapiens_hsa051100.63408466
55Arachidonic acid metabolism_Homo sapiens_hsa005900.62781134
56Metabolic pathways_Homo sapiens_hsa011000.61490722
57Collecting duct acid secretion_Homo sapiens_hsa049660.60822534
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59985728
59Sulfur relay system_Homo sapiens_hsa041220.58837975
60Regulation of autophagy_Homo sapiens_hsa041400.58829737
61Legionellosis_Homo sapiens_hsa051340.58394140
62Antigen processing and presentation_Homo sapiens_hsa046120.58099230
63Allograft rejection_Homo sapiens_hsa053300.57598905
64Butanoate metabolism_Homo sapiens_hsa006500.56576472
65Caffeine metabolism_Homo sapiens_hsa002320.56547661
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55059272
67Asthma_Homo sapiens_hsa053100.54626775
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51443040
69Oocyte meiosis_Homo sapiens_hsa041140.50943239
70Vitamin digestion and absorption_Homo sapiens_hsa049770.49862596
71Rheumatoid arthritis_Homo sapiens_hsa053230.49789006
72Chemical carcinogenesis_Homo sapiens_hsa052040.47270439
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47048949
74Tryptophan metabolism_Homo sapiens_hsa003800.46418825
75Ether lipid metabolism_Homo sapiens_hsa005650.44812757
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.43360604
77Primary immunodeficiency_Homo sapiens_hsa053400.43163119
78Fatty acid degradation_Homo sapiens_hsa000710.42909396
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42197756
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.42197329
81Linoleic acid metabolism_Homo sapiens_hsa005910.41500367
82Herpes simplex infection_Homo sapiens_hsa051680.39118126
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36699231
84Phagosome_Homo sapiens_hsa041450.36394279
85Vitamin B6 metabolism_Homo sapiens_hsa007500.36278268
86Viral carcinogenesis_Homo sapiens_hsa052030.35548731
87beta-Alanine metabolism_Homo sapiens_hsa004100.34263211
88Autoimmune thyroid disease_Homo sapiens_hsa053200.34049921
89Fatty acid metabolism_Homo sapiens_hsa012120.33817603
90Phototransduction_Homo sapiens_hsa047440.33256417
91Shigellosis_Homo sapiens_hsa051310.33162985
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32780414
93Type I diabetes mellitus_Homo sapiens_hsa049400.32573334
94Retinol metabolism_Homo sapiens_hsa008300.30429543
95Hematopoietic cell lineage_Homo sapiens_hsa046400.29715080
96Carbon metabolism_Homo sapiens_hsa012000.29665985
97Biosynthesis of amino acids_Homo sapiens_hsa012300.26633973
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25857840
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25716153
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25155226
101Arginine and proline metabolism_Homo sapiens_hsa003300.23826927
102N-Glycan biosynthesis_Homo sapiens_hsa005100.23091915
103Sphingolipid metabolism_Homo sapiens_hsa006000.22939050
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22227242
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.20671749
106Fructose and mannose metabolism_Homo sapiens_hsa000510.20029860
107Alcoholism_Homo sapiens_hsa050340.19437887
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19174401
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17916710
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.17644682
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17457959
112Galactose metabolism_Homo sapiens_hsa000520.16204655
113Tyrosine metabolism_Homo sapiens_hsa003500.15602996
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14956318
115Pyruvate metabolism_Homo sapiens_hsa006200.14898299
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13942481
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.12986402
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.12003694
119Phenylalanine metabolism_Homo sapiens_hsa003600.11670875
120Sulfur metabolism_Homo sapiens_hsa009200.11271951
121Fat digestion and absorption_Homo sapiens_hsa049750.11220563
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.09564458
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.08856301
124HTLV-I infection_Homo sapiens_hsa051660.08812005
125Measles_Homo sapiens_hsa051620.08199207
126Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.07891285
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07751828
128Apoptosis_Homo sapiens_hsa042100.07068626

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