PSMA2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mesenchymal-epithelial cell signaling (GO:0060638)8.88211399
2GMP metabolic process (GO:0046037)8.69625281
3regulation of branching involved in salivary gland morphogenesis (GO:0060693)8.25850219
4trivalent inorganic anion homeostasis (GO:0072506)7.05279417
5phosphate ion homeostasis (GO:0055062)7.05279417
6renal system development (GO:0072001)6.39093120
7keratan sulfate catabolic process (GO:0042340)5.77499380
8decidualization (GO:0046697)5.40322846
9peptidyl-proline hydroxylation (GO:0019511)5.37707116
10cell wall macromolecule catabolic process (GO:0016998)5.10088691
11multicellular organismal aging (GO:0010259)5.08589665
12cullin deneddylation (GO:0010388)5.01056133
13radial glial cell differentiation (GO:0060019)4.80494409
14protein deneddylation (GO:0000338)4.70237946
15regulation of DNA damage checkpoint (GO:2000001)4.66432726
16limb bud formation (GO:0060174)4.63303745
17positive regulation of receptor internalization (GO:0002092)4.56653430
18regulation of keratinocyte proliferation (GO:0010837)4.55328035
19regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)4.29571039
20positive regulation of epidermal cell differentiation (GO:0045606)4.25177194
21protein localization to cell surface (GO:0034394)4.24499963
22cell wall macromolecule metabolic process (GO:0044036)4.19927021
23protein hydroxylation (GO:0018126)4.08811137
24otic vesicle formation (GO:0030916)4.06091992
25purine nucleotide salvage (GO:0032261)3.95522986
26mesenchymal cell proliferation (GO:0010463)3.94908312
27regulation of double-strand break repair via homologous recombination (GO:0010569)3.87944693
28proteasome assembly (GO:0043248)3.84889342
29artery development (GO:0060840)3.81897822
30spliceosomal complex assembly (GO:0000245)3.80733511
31chondrocyte proliferation (GO:0035988)3.80035849
32keratan sulfate biosynthetic process (GO:0018146)3.74845207
33positive regulation of DNA repair (GO:0045739)3.72081738
34water-soluble vitamin biosynthetic process (GO:0042364)3.69850926
35organelle disassembly (GO:1903008)3.68595948
36detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.66508568
37regulation of cardiac muscle cell contraction (GO:0086004)3.62617149
38toxin metabolic process (GO:0009404)3.62505356
39mesonephros development (GO:0001823)3.45246304
40branching involved in salivary gland morphogenesis (GO:0060445)3.44153325
41IMP biosynthetic process (GO:0006188)3.42252760
42lateral sprouting from an epithelium (GO:0060601)3.40911883
43lung secretory cell differentiation (GO:0061140)3.39339176
44regulation of female gonad development (GO:2000194)3.35943774
45lung epithelium development (GO:0060428)3.33829522
46regulation of protein glycosylation (GO:0060049)3.31357162
47IMP metabolic process (GO:0046040)3.25009851
48hair follicle morphogenesis (GO:0031069)3.23793808
49branch elongation of an epithelium (GO:0060602)3.18503672
50collagen fibril organization (GO:0030199)3.18368338
51regulation of actin filament-based movement (GO:1903115)3.16102524
52inner ear receptor stereocilium organization (GO:0060122)3.15343876
53embryonic digestive tract morphogenesis (GO:0048557)3.09372523
54organ formation (GO:0048645)3.07729033
55purine-containing compound salvage (GO:0043101)3.07509153
56mitotic G1/S transition checkpoint (GO:0044819)3.02219171
57nucleotide transmembrane transport (GO:1901679)3.02088320
58mitotic G1 DNA damage checkpoint (GO:0031571)3.00913728
59signal peptide processing (GO:0006465)3.00834989
60purine nucleobase biosynthetic process (GO:0009113)3.00473759
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99632026
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99632026
63negative regulation of stress-activated MAPK cascade (GO:0032873)2.97191213
64negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)2.97191213
65regulation of receptor internalization (GO:0002090)2.96371586
66intra-S DNA damage checkpoint (GO:0031573)2.94493868
67protein localization to cilium (GO:0061512)2.91595561
68muscle cell fate commitment (GO:0042693)2.91173264
69negative regulation of fibroblast apoptotic process (GO:2000270)2.88395080
70keratan sulfate metabolic process (GO:0042339)2.87056737
71positive regulation of receptor-mediated endocytosis (GO:0048260)2.86854869
72platelet-derived growth factor receptor signaling pathway (GO:0048008)2.86780287
73platelet dense granule organization (GO:0060155)2.86639722
74response to X-ray (GO:0010165)2.79210830
75kidney morphogenesis (GO:0060993)2.76559765
76L-fucose metabolic process (GO:0042354)2.76255828
77L-fucose catabolic process (GO:0042355)2.76255828
78fucose catabolic process (GO:0019317)2.76255828
79keratinocyte development (GO:0003334)2.75724200
80peptidyl-histidine modification (GO:0018202)2.74850118
81negative regulation of JNK cascade (GO:0046329)2.73287371
82recombinational repair (GO:0000725)2.70081583
83intracellular protein transmembrane transport (GO:0065002)2.69533043
84mismatch repair (GO:0006298)2.68648929
85double-strand break repair via homologous recombination (GO:0000724)2.67465931
86bone trabecula formation (GO:0060346)2.67377226
87positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.67050046
88rRNA catabolic process (GO:0016075)2.65736632
89outer ear morphogenesis (GO:0042473)2.65340836
90chondrocyte development (GO:0002063)2.64571278
91genitalia morphogenesis (GO:0035112)2.63170445
92negative regulation of DNA-dependent DNA replication (GO:2000104)2.63042631
93nucleotide-excision repair, DNA gap filling (GO:0006297)2.61237042
94RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.60498421
95establishment of protein localization to mitochondrial membrane (GO:0090151)2.60001285
96detection of mechanical stimulus involved in sensory perception (GO:0050974)2.59696614
97negative regulation of endothelial cell migration (GO:0010596)2.59575823
98nucleotide salvage (GO:0043173)2.59154185
99female gonad development (GO:0008585)2.59110514
100transcytosis (GO:0045056)2.58920364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.22226935
2VDR_22108803_ChIP-Seq_LS180_Human3.23609120
3POU3F2_20337985_ChIP-ChIP_501MEL_Human3.14871674
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.03872782
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.92435420
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.82894764
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.78031071
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.76502208
9GATA1_22025678_ChIP-Seq_K562_Human2.49616403
10PCGF2_27294783_Chip-Seq_NPCs_Mouse2.24150414
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10076552
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09484764
13EWS_26573619_Chip-Seq_HEK293_Human2.05922277
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.02232988
15P300_19829295_ChIP-Seq_ESCs_Human2.01403912
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96930133
17GBX2_23144817_ChIP-Seq_PC3_Human1.95609930
18CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.89464973
19FUS_26573619_Chip-Seq_HEK293_Human1.88988097
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.88741098
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85422936
22NANOG_19829295_ChIP-Seq_ESCs_Human1.82459167
23SOX2_19829295_ChIP-Seq_ESCs_Human1.82459167
24EZH2_27294783_Chip-Seq_NPCs_Mouse1.75584253
25CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.73758629
26CBP_20019798_ChIP-Seq_JUKART_Human1.73572098
27IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.73572098
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72511618
29TOP2B_26459242_ChIP-Seq_MCF-7_Human1.71422374
30LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70704368
31CDX2_22108803_ChIP-Seq_LS180_Human1.70646269
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.64822901
33CJUN_26792858_Chip-Seq_BT549_Human1.62495613
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61059284
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60951603
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59896314
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57058497
38ER_23166858_ChIP-Seq_MCF-7_Human1.55034524
39FLI1_21867929_ChIP-Seq_TH2_Mouse1.53948124
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53308311
41AR_25329375_ChIP-Seq_VCAP_Human1.52399780
42BCAT_22108803_ChIP-Seq_LS180_Human1.52035393
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51944344
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51764367
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51124574
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49666435
47TAF15_26573619_Chip-Seq_HEK293_Human1.48030192
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.47889923
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.47476517
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.44981357
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44901877
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44103476
53AR_21572438_ChIP-Seq_LNCaP_Human1.41259014
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.40526483
55FOXM1_26456572_ChIP-Seq_MCF-7_Human1.38109632
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36471728
57SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.35760403
58TCF4_23295773_ChIP-Seq_U87_Human1.33540947
59ELK1_19687146_ChIP-ChIP_HELA_Human1.33068243
60SMAD4_21799915_ChIP-Seq_A2780_Human1.32634340
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31601221
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30283918
63TP53_18474530_ChIP-ChIP_U2OS_Human1.29481261
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29210655
65TAL1_26923725_Chip-Seq_HPCs_Mouse1.28648240
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.28134347
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26850452
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26625333
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26302586
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26262382
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25700891
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25700891
73STAT3_23295773_ChIP-Seq_U87_Human1.23396718
74TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.21961850
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.21868618
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21702638
77VDR_24787735_ChIP-Seq_THP-1_Human1.21043458
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18941187
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17575617
80CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17479581
81ZNF274_21170338_ChIP-Seq_K562_Hela1.17208235
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16306456
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.15880942
84HTT_18923047_ChIP-ChIP_STHdh_Human1.15827748
85TP53_16413492_ChIP-PET_HCT116_Human1.15774095
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15168007
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15168007
88OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14412514
89TCF4_22108803_ChIP-Seq_LS180_Human1.12481082
90RUNX2_22187159_ChIP-Seq_PCA_Human1.12208943
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10831012
92P53_22387025_ChIP-Seq_ESCs_Mouse1.10604891
93EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09722919
94IGF1R_20145208_ChIP-Seq_DFB_Human1.08567424
95SALL4_22934838_ChIP-ChIP_CD34+_Human1.05184392
96SOX2_18555785_Chip-Seq_ESCs_Mouse1.03590785
97WT1_19549856_ChIP-ChIP_CCG9911_Human0.99678985
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99289690
99KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99186421
100POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98695018

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile5.70534927
2MP0005503_abnormal_tendon_morphology5.60829478
3MP0006054_spinal_hemorrhage4.23010821
4MP0002102_abnormal_ear_morphology4.18557015
5MP0006072_abnormal_retinal_apoptosis3.48222741
6MP0002132_abnormal_respiratory_system2.82868667
7MP0005248_abnormal_Harderian_gland2.58454172
8MP0001986_abnormal_taste_sensitivity2.57669881
9MP0000566_synostosis2.56764128
10MP0006292_abnormal_olfactory_placode2.43239530
11MP0009250_abnormal_appendicular_skeleto2.31268999
12MP0001529_abnormal_vocalization2.28619774
13MP0004272_abnormal_basement_membrane2.19396861
14MP0001542_abnormal_bone_strength2.18997845
15MP0005253_abnormal_eye_physiology2.15704932
16MP0010030_abnormal_orbit_morphology1.97271276
17MP0005408_hypopigmentation1.93890400
18MP0008058_abnormal_DNA_repair1.93841478
19MP0003567_abnormal_fetal_cardiomyocyte1.87028418
20MP0000372_irregular_coat_pigmentation1.86588502
21MP0005508_abnormal_skeleton_morphology1.85188736
22MP0008877_abnormal_DNA_methylation1.71207440
23MP0008995_early_reproductive_senescence1.64763498
24MP0002233_abnormal_nose_morphology1.63308090
25MP0001984_abnormal_olfaction1.63252413
26MP0008438_abnormal_cutaneous_collagen1.60592365
27MP0002938_white_spotting1.59663523
28MP0003195_calcinosis1.58991235
29MP0000681_abnormal_thyroid_gland1.55666253
30MP0003880_abnormal_central_pattern1.54524330
31MP0003937_abnormal_limbs/digits/tail_de1.52931820
32MP0001243_abnormal_dermal_layer1.52393553
33MP0002396_abnormal_hematopoietic_system1.51566540
34MP0000613_abnormal_salivary_gland1.39472629
35MP0002638_abnormal_pupillary_reflex1.37330771
36MP0005360_urolithiasis1.34062510
37MP0005257_abnormal_intraocular_pressure1.28865672
38MP0002282_abnormal_trachea_morphology1.28612729
39MP0003786_premature_aging1.25691911
40MP0002108_abnormal_muscle_morphology1.24539047
41MP0002295_abnormal_pulmonary_circulatio1.22311814
42MP0004147_increased_porphyrin_level1.20590690
43MP0005171_absent_coat_pigmentation1.20295286
44MP0002115_abnormal_skeleton_extremities1.17484891
45MP0004215_abnormal_myocardial_fiber1.14041839
46MP0003755_abnormal_palate_morphology1.12322794
47MP0008789_abnormal_olfactory_epithelium1.09489330
48MP0002168_other_aberrant_phenotype1.08332593
49MP0009780_abnormal_chondrocyte_physiolo1.04920727
50MP0005647_abnormal_sex_gland1.04438385
51MP0001286_abnormal_eye_development1.00691903
52MP0002736_abnormal_nociception_after0.96827758
53MP0003938_abnormal_ear_development0.96732982
54MP0003935_abnormal_craniofacial_develop0.96081718
55MP0004484_altered_response_of0.94373056
56MP0003221_abnormal_cardiomyocyte_apopto0.94319429
57MP0003119_abnormal_digestive_system0.92103357
58MP0003646_muscle_fatigue0.91665628
59MP0002109_abnormal_limb_morphology0.91482992
60MP0000163_abnormal_cartilage_morphology0.90203438
61MP0002876_abnormal_thyroid_physiology0.87191322
62MP0000639_abnormal_adrenal_gland0.86071456
63MP0004085_abnormal_heartbeat0.85973874
64MP0003950_abnormal_plasma_membrane0.83941946
65MP0003693_abnormal_embryo_hatching0.80403807
66MP0002896_abnormal_bone_mineralization0.78810024
67MP0000432_abnormal_head_morphology0.77472954
68MP0000383_abnormal_hair_follicle0.77226912
69MP0003936_abnormal_reproductive_system0.76919811
70MP0002277_abnormal_respiratory_mucosa0.74963739
71MP0010094_abnormal_chromosome_stability0.74900653
72MP0002111_abnormal_tail_morphology0.73659030
73MP0000013_abnormal_adipose_tissue0.73182472
74MP0008872_abnormal_physiological_respon0.72669763
75MP0001191_abnormal_skin_condition0.70241461
76MP0002234_abnormal_pharynx_morphology0.70219163
77MP0005499_abnormal_olfactory_system0.70038952
78MP0005394_taste/olfaction_phenotype0.70038952
79MP0005391_vision/eye_phenotype0.68759041
80MP0002254_reproductive_system_inflammat0.68580579
81MP0002006_tumorigenesis0.67384526
82MP0002095_abnormal_skin_pigmentation0.65958818
83MP0001340_abnormal_eyelid_morphology0.62479599
84MP0002932_abnormal_joint_morphology0.60328028
85MP0001919_abnormal_reproductive_system0.60100522
86MP0000015_abnormal_ear_pigmentation0.59311967
87MP0003942_abnormal_urinary_system0.58836278
88MP0002177_abnormal_outer_ear0.58721524
89MP0002184_abnormal_innervation0.58691555
90MP0001485_abnormal_pinna_reflex0.58241230
91MP0005075_abnormal_melanosome_morpholog0.58207862
92MP0005389_reproductive_system_phenotype0.57716891
93MP0000749_muscle_degeneration0.56724217
94MP0000750_abnormal_muscle_regeneration0.55278714
95MP0003385_abnormal_body_wall0.54687277
96MP0005395_other_phenotype0.54593691
97MP0004883_abnormal_blood_vessel0.53716843
98MP0004145_abnormal_muscle_electrophysio0.53392079
99MP0005023_abnormal_wound_healing0.52811921
100MP0009764_decreased_sensitivity_to0.52404540

Predicted human phenotypes

RankGene SetZ-score
1Absent frontal sinuses (HP:0002688)6.80353821
2Subacute progressive viral hepatitis (HP:0006572)5.64845090
3Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)5.38452098
4Back pain (HP:0003418)4.88122689
5Metaphyseal dysplasia (HP:0100255)4.80992217
6Abnormality of the frontal sinuses (HP:0002687)4.70148727
7Pigmentary retinal degeneration (HP:0001146)4.42037820
8Spondylolisthesis (HP:0003302)4.41428292
9Aplasia/Hypoplasia involving the sinuses (HP:0009120)4.30741926
10Abnormality of the phalanges of the 2nd finger (HP:0009541)3.96111775
11Micronodular cirrhosis (HP:0001413)3.62080695
12Choroideremia (HP:0001139)3.46496675
13Viral hepatitis (HP:0006562)3.33197005
14Aplasia involving bones of the extremities (HP:0009825)3.32299216
15Aplasia involving bones of the upper limbs (HP:0009823)3.32299216
16Aplasia of the phalanges of the hand (HP:0009802)3.32299216
17Birth length less than 3rd percentile (HP:0003561)3.30984015
18Abnormality of the labia minora (HP:0012880)3.14462903
19Delayed closure of the anterior fontanelle (HP:0001476)2.92107718
20Abnormality of incisor morphology (HP:0011063)2.77708024
21Breast hypoplasia (HP:0003187)2.76452402
22Hepatocellular carcinoma (HP:0001402)2.75606440
23Aplastic anemia (HP:0001915)2.65677733
24Osteolytic defects of the hand bones (HP:0009699)2.64070088
25Osteolytic defects of the phalanges of the hand (HP:0009771)2.64070088
26Breech presentation (HP:0001623)2.63813096
27Long clavicles (HP:0000890)2.62521499
28Triphalangeal thumb (HP:0001199)2.55835405
29Chromsome breakage (HP:0040012)2.51940523
30Small hand (HP:0200055)2.50397656
31Progressive cerebellar ataxia (HP:0002073)2.49747784
32Cystic liver disease (HP:0006706)2.48284896
33Cutaneous finger syndactyly (HP:0010554)2.48083157
34Metaphyseal cupping (HP:0003021)2.46730398
35Persistence of primary teeth (HP:0006335)2.46712401
36Short tibia (HP:0005736)2.46430154
37Abnormality of cochlea (HP:0000375)2.43217570
38Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.38321983
39Abnormal lung lobation (HP:0002101)2.37580702
40Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.32406013
41Morphological abnormality of the middle ear (HP:0008609)2.31184465
42Aplasia/Hypoplasia of the tibia (HP:0005772)2.29757759
43Aplasia/Hypoplasia of the ulna (HP:0006495)2.23728551
44Absent radius (HP:0003974)2.20471731
45Abnormality of the 2nd finger (HP:0004100)2.20122308
46Hypoplasia of the ulna (HP:0003022)2.19933696
47Fibular aplasia (HP:0002990)2.11566461
48Abnormality of the ischium (HP:0003174)2.09152870
49Aplasia involving forearm bones (HP:0009822)2.08439297
50Absent forearm bone (HP:0003953)2.08439297
51Decreased lacrimation (HP:0000633)2.07002112
52Prostate neoplasm (HP:0100787)2.06480985
53Neoplasm of the liver (HP:0002896)2.05139275
54Hyperglycinemia (HP:0002154)2.04695376
55Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.02141653
56Hypoplastic pelvis (HP:0008839)2.01515036
57Aplasia/Hypoplasia of the fibula (HP:0006492)2.01103827
58Anomalous pulmonary venous return (HP:0010772)2.01040089
59Preaxial foot polydactyly (HP:0001841)2.01008402
60Abnormality of the phalanges of the 5th finger (HP:0004213)1.99655131
61Cutaneous syndactyly (HP:0012725)1.99341750
62Myelomeningocele (HP:0002475)1.97419507
63Mild short stature (HP:0003502)1.95443524
64Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.94878466
65Hypoplastic ischia (HP:0003175)1.94431665
66Delayed cranial suture closure (HP:0000270)1.93383784
67Vitreoretinal degeneration (HP:0000655)1.92810726
68Transitional cell carcinoma of the bladder (HP:0006740)1.92443476
69Short ribs (HP:0000773)1.92399699
70Uterine leiomyosarcoma (HP:0002891)1.91618169
71Leiomyosarcoma (HP:0100243)1.91618169
72Aplasia/Hypoplasia of the uvula (HP:0010293)1.90381479
73Broad hallux (HP:0010055)1.89529555
74Arthropathy (HP:0003040)1.89141472
75Thyroiditis (HP:0100646)1.87982274
76Partial duplication of the phalanx of hand (HP:0009999)1.86604000
77Bifid tongue (HP:0010297)1.86078648
78Morphological abnormality of the inner ear (HP:0011390)1.85173450
79Facial hemangioma (HP:0000329)1.84305105
80Postaxial foot polydactyly (HP:0001830)1.83943964
81Fibular hypoplasia (HP:0003038)1.83649921
82Atrophic scars (HP:0001075)1.83207395
83Short 4th metacarpal (HP:0010044)1.82797819
84Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82797819
85Hepatocellular necrosis (HP:0001404)1.81705876
86Infantile muscular hypotonia (HP:0008947)1.80250190
87Shawl scrotum (HP:0000049)1.80113046
88Methylmalonic acidemia (HP:0002912)1.79295485
89Increased serum pyruvate (HP:0003542)1.77665273
90Bicornuate uterus (HP:0000813)1.77416772
91Nephroblastoma (Wilms tumor) (HP:0002667)1.76925861
92Partial duplication of thumb phalanx (HP:0009944)1.76013142
93Chromosomal breakage induced by crosslinking agents (HP:0003221)1.75561910
94Aplasia/Hypoplasia of the sternum (HP:0006714)1.74620570
95Broad toe (HP:0001837)1.74396690
96Embryonal renal neoplasm (HP:0011794)1.70817191
97Bladder neoplasm (HP:0009725)1.69343888
98Bladder carcinoma (HP:0002862)1.69343888
99Rib fusion (HP:0000902)1.69148304
100Bilateral sensorineural hearing impairment (HP:0008619)1.68409626

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT33.76060860
2FRK3.32267885
3SGK23.06681010
4NLK2.76936672
5WNK32.63181756
6MAP3K122.35999943
7NUAK12.27984625
8SGK4942.03156663
9SGK2232.03156663
10VRK12.00627039
11MAP4K21.89539681
12NEK11.82991474
13TEC1.82417133
14SGK31.79739416
15MST41.73815292
16PAK31.69259657
17BMPR1B1.65614436
18SRPK11.62882345
19BRSK21.61436899
20OXSR11.59753340
21TGFBR21.59581122
22VRK21.48933646
23EIF2AK31.48360868
24PDK21.47609228
25CDK191.39450870
26ZAK1.38813795
27BLK1.31641561
28MYLK1.29313484
29TRIM281.26113636
30ADRBK21.24267102
31CSNK1G11.23696850
32TYK21.22580091
33RIPK41.20349471
34STK38L1.18440592
35FGFR11.11599525
36GRK71.07103401
37WEE11.05049453
38OBSCN1.04453614
39INSRR1.02222700
40WNK41.01849888
41STK41.00979842
42FER0.97571940
43PRKCE0.96185724
44KSR20.96100929
45CAMK40.94607272
46GSK3A0.93936567
47ERBB30.93148847
48MKNK10.92984964
49STK160.91536786
50PLK30.90129036
51MAP3K40.89210882
52PAK60.89092090
53IRAK10.88203759
54ITK0.87236093
55BCKDK0.86910989
56PRKD30.86602262
57ATR0.86205450
58TAF10.85277866
59GRK10.84709410
60RAF10.83128493
61STK30.81860755
62ATM0.79042841
63TSSK60.78832790
64KSR10.72218789
65MKNK20.71238641
66TAOK30.70796748
67GRK50.68432083
68AKT20.67638190
69ERBB40.67362461
70STK390.62422458
71MAPK130.60421239
72TLK10.58980471
73CAMK2D0.58748822
74BCR0.57535003
75LATS10.55903871
76PIK3CA0.53159452
77TNIK0.51355019
78CSF1R0.49784946
79FGFR30.48909826
80CDK80.48840903
81ADRBK10.48294948
82TIE10.47737048
83SGK10.45672472
84CSNK1G20.45528426
85MINK10.45427639
86CAMK2A0.43530033
87PRKAA20.43482281
88PLK20.43346262
89PRKACB0.42010585
90HIPK20.41033554
91MAPKAPK50.41028397
92INSR0.40685973
93MAPKAPK30.40205977
94DYRK30.38391956
95CSNK1G30.37675783
96PDGFRB0.37083252
97IGF1R0.36539309
98EIF2AK20.34018173
99PINK10.32954872
100CASK0.32484114

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030607.80100956
2Mismatch repair_Homo sapiens_hsa034305.00261069
3Homologous recombination_Homo sapiens_hsa034404.57627856
4Non-homologous end-joining_Homo sapiens_hsa034502.96266608
5DNA replication_Homo sapiens_hsa030302.68887417
6Fanconi anemia pathway_Homo sapiens_hsa034602.67515800
7Nucleotide excision repair_Homo sapiens_hsa034202.54569529
8Proteasome_Homo sapiens_hsa030502.46643349
9Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.00456763
10Propanoate metabolism_Homo sapiens_hsa006401.98527889
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.96843433
12Caffeine metabolism_Homo sapiens_hsa002321.94244294
13Steroid biosynthesis_Homo sapiens_hsa001001.46697491
14ABC transporters_Homo sapiens_hsa020101.40463782
15Melanoma_Homo sapiens_hsa052181.32709703
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28492956
17Oxidative phosphorylation_Homo sapiens_hsa001901.27991983
18ECM-receptor interaction_Homo sapiens_hsa045121.25332206
19Malaria_Homo sapiens_hsa051441.12262442
20RNA degradation_Homo sapiens_hsa030181.11984983
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11481161
22Basal transcription factors_Homo sapiens_hsa030221.09956932
23Nitrogen metabolism_Homo sapiens_hsa009101.06264823
24Taste transduction_Homo sapiens_hsa047421.04497774
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01893141
26Sulfur metabolism_Homo sapiens_hsa009200.98421293
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97508661
28Basal cell carcinoma_Homo sapiens_hsa052170.96474921
29Linoleic acid metabolism_Homo sapiens_hsa005910.94711000
30Olfactory transduction_Homo sapiens_hsa047400.91520326
31Vibrio cholerae infection_Homo sapiens_hsa051100.90625699
32SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90199637
33Parkinsons disease_Homo sapiens_hsa050120.86206998
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83993873
35mRNA surveillance pathway_Homo sapiens_hsa030150.82827245
36Fatty acid elongation_Homo sapiens_hsa000620.80280464
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76654306
38Morphine addiction_Homo sapiens_hsa050320.74709721
39Drug metabolism - other enzymes_Homo sapiens_hsa009830.73976403
40Ovarian steroidogenesis_Homo sapiens_hsa049130.73828862
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73828542
42Arginine and proline metabolism_Homo sapiens_hsa003300.73343303
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73197757
44Glutathione metabolism_Homo sapiens_hsa004800.73157102
45Protein digestion and absorption_Homo sapiens_hsa049740.72626841
46Retinol metabolism_Homo sapiens_hsa008300.72004737
47Ether lipid metabolism_Homo sapiens_hsa005650.70528125
48Wnt signaling pathway_Homo sapiens_hsa043100.67686355
49RNA transport_Homo sapiens_hsa030130.67448353
50Hedgehog signaling pathway_Homo sapiens_hsa043400.67254620
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66879155
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66106506
53Arachidonic acid metabolism_Homo sapiens_hsa005900.64902119
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.61769355
55Dilated cardiomyopathy_Homo sapiens_hsa054140.61656838
56Collecting duct acid secretion_Homo sapiens_hsa049660.61326622
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61067248
58Chemical carcinogenesis_Homo sapiens_hsa052040.58882325
59N-Glycan biosynthesis_Homo sapiens_hsa005100.56476874
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55457443
61Phototransduction_Homo sapiens_hsa047440.54287736
62Salivary secretion_Homo sapiens_hsa049700.53912277
63Purine metabolism_Homo sapiens_hsa002300.52982262
64Butanoate metabolism_Homo sapiens_hsa006500.52883708
65TGF-beta signaling pathway_Homo sapiens_hsa043500.51889025
66Huntingtons disease_Homo sapiens_hsa050160.50667727
67PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50657592
68Selenocompound metabolism_Homo sapiens_hsa004500.48317381
69Rheumatoid arthritis_Homo sapiens_hsa053230.47575865
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47433383
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46892843
72Tryptophan metabolism_Homo sapiens_hsa003800.42068491
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40845530
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39744138
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39426255
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37898978
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36984967
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36974316
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.35036805
80Focal adhesion_Homo sapiens_hsa045100.33957383
81Asthma_Homo sapiens_hsa053100.32371553
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.31141431
83Peroxisome_Homo sapiens_hsa041460.30431324
84Complement and coagulation cascades_Homo sapiens_hsa046100.30236977
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30014002
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29632314
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.26877811
88Platelet activation_Homo sapiens_hsa046110.26046419
89Proteoglycans in cancer_Homo sapiens_hsa052050.25625909
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.25229130
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23304267
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.22696474
93Pyruvate metabolism_Homo sapiens_hsa006200.22693568
94Circadian entrainment_Homo sapiens_hsa047130.22290173
95Ribosome_Homo sapiens_hsa030100.21266520
96Metabolic pathways_Homo sapiens_hsa011000.19699800
97Systemic lupus erythematosus_Homo sapiens_hsa053220.19600856
98Melanogenesis_Homo sapiens_hsa049160.19337562
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19166559
100Pathways in cancer_Homo sapiens_hsa052000.19040786

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