PSMA2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.34735757
2oxygen transport (GO:0015671)9.21505914
3single strand break repair (GO:0000012)9.19954898
4fusion of sperm to egg plasma membrane (GO:0007342)9.19241750
5gas transport (GO:0015669)8.58417228
6protein polyglutamylation (GO:0018095)8.53808310
7response to pheromone (GO:0019236)8.19272420
8sperm motility (GO:0030317)8.17535417
9plasma membrane fusion (GO:0045026)7.02643409
10sperm capacitation (GO:0048240)6.94680249
11rRNA methylation (GO:0031167)6.85035454
12DNA packaging (GO:0006323)6.70908799
13chromosome condensation (GO:0030261)6.66937819
14microtubule depolymerization (GO:0007019)6.26662509
15spermatid development (GO:0007286)6.13242459
16sperm-egg recognition (GO:0035036)6.12707990
17rRNA modification (GO:0000154)6.11650818
18estrogen biosynthetic process (GO:0006703)5.79935210
19spermatid nucleus differentiation (GO:0007289)5.78391699
20multicellular organism reproduction (GO:0032504)5.73234888
21binding of sperm to zona pellucida (GO:0007339)5.58490954
22reproduction (GO:0000003)5.36816163
23calcium ion-dependent exocytosis (GO:0017156)5.20220202
24cell-cell recognition (GO:0009988)5.10501921
25sexual reproduction (GO:0019953)5.09583748
26negative regulation of sodium ion transport (GO:0010766)4.93649624
27negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.82530109
28microtubule polymerization or depolymerization (GO:0031109)4.81902293
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.62479214
30glycerol ether metabolic process (GO:0006662)4.61617140
31phosphatidylethanolamine biosynthetic process (GO:0006646)4.55683879
32axonemal dynein complex assembly (GO:0070286)4.53815876
33spermatogenesis (GO:0007283)4.53419150
34male gamete generation (GO:0048232)4.51287200
35regulation of interleukin-13 production (GO:0032656)4.32935253
36ether metabolic process (GO:0018904)4.26842748
37cellular ketone body metabolic process (GO:0046950)4.22467362
38phosphatidylethanolamine metabolic process (GO:0046337)4.13868180
39negative regulation of potassium ion transmembrane transport (GO:1901380)4.11309209
40gamete generation (GO:0007276)4.08333145
41polyamine biosynthetic process (GO:0006596)4.05920492
42negative regulation of inclusion body assembly (GO:0090084)3.95152827
43microtubule severing (GO:0051013)3.93838595
44protein targeting to Golgi (GO:0000042)3.91473477
45centriole replication (GO:0007099)3.90846523
46S-adenosylmethionine metabolic process (GO:0046500)3.83101738
47single fertilization (GO:0007338)3.82363167
48regulation of transcription involved in cell fate commitment (GO:0060850)3.80795453
49positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.79365692
50homocysteine metabolic process (GO:0050667)3.79248020
51GPI anchor biosynthetic process (GO:0006506)3.78998322
52ketone body metabolic process (GO:1902224)3.76565392
53regulation of cilium movement (GO:0003352)3.74709414
54establishment of protein localization to Golgi (GO:0072600)3.73669900
55cell wall macromolecule catabolic process (GO:0016998)3.72742294
56cell wall macromolecule metabolic process (GO:0044036)3.68028079
57retrograde transport, vesicle recycling within Golgi (GO:0000301)3.64852529
58positive regulation of Rab GTPase activity (GO:0032851)3.63508126
59regulation of Rab GTPase activity (GO:0032313)3.63508126
60definitive hemopoiesis (GO:0060216)3.61633719
61regulation of chronic inflammatory response (GO:0002676)3.57664211
62GPI anchor metabolic process (GO:0006505)3.56453951
63organic cation transport (GO:0015695)3.55066330
64chromatin silencing (GO:0006342)3.54584509
65histone exchange (GO:0043486)3.44616731
66axoneme assembly (GO:0035082)3.43894083
67negative regulation of systemic arterial blood pressure (GO:0003085)3.32416033
68coenzyme catabolic process (GO:0009109)3.28593145
69cilium or flagellum-dependent cell motility (GO:0001539)3.27199909
70regulation of centriole replication (GO:0046599)3.25721306
71tyrosine phosphorylation of STAT protein (GO:0007260)3.22134457
72regulation of tight junction assembly (GO:2000810)3.19549217
73multicellular organismal reproductive process (GO:0048609)3.19485519
74regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.18671096
75cellular process involved in reproduction in multicellular organism (GO:0022412)3.16769192
76piRNA metabolic process (GO:0034587)3.15823120
77cofactor catabolic process (GO:0051187)3.15787934
78germ cell development (GO:0007281)3.13067598
79centriole assembly (GO:0098534)3.10553481
80negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.09188127
81negative regulation of T-helper cell differentiation (GO:0045623)3.09188127
82CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.04419049
83regulation of isotype switching to IgG isotypes (GO:0048302)2.99435232
84cellular biogenic amine biosynthetic process (GO:0042401)2.93023350
85fertilization (GO:0009566)2.87473126
86proteasome assembly (GO:0043248)2.85266434
87cerebral cortex neuron differentiation (GO:0021895)2.84868900
88seminiferous tubule development (GO:0072520)2.83413535
89regulation of MHC class II biosynthetic process (GO:0045346)2.79902578
90mesenchymal cell differentiation involved in renal system development (GO:2001012)2.79579622
91mesenchymal cell differentiation involved in kidney development (GO:0072161)2.79579622
92mannosylation (GO:0097502)2.78800459
93preassembly of GPI anchor in ER membrane (GO:0016254)2.77115592
94cell differentiation involved in metanephros development (GO:0072202)2.77112114
95detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.75931347
96one-carbon compound transport (GO:0019755)2.75748210
97regulation of proton transport (GO:0010155)2.75373325
98Golgi to endosome transport (GO:0006895)2.74035367
99amine biosynthetic process (GO:0009309)2.72965087
100natural killer cell differentiation (GO:0001779)2.71713110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.80515618
2VDR_22108803_ChIP-Seq_LS180_Human3.52764741
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.50132559
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.47200286
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.95839096
6GATA1_22025678_ChIP-Seq_K562_Human2.67690008
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.41249782
8EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.36816747
9CBP_20019798_ChIP-Seq_JUKART_Human2.25394342
10IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.25394342
11RBPJ_21746931_ChIP-Seq_IB4_Human2.23322025
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15439812
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.11440270
14FUS_26573619_Chip-Seq_HEK293_Human2.10730937
15GATA1_19941826_ChIP-Seq_K562_Human2.07697692
16HNFA_21074721_ChIP-Seq_CACO-2_Human2.07295241
17VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.06577816
18ER_23166858_ChIP-Seq_MCF-7_Human2.03614758
19CBX2_22325352_ChIP-Seq_293T-Rex_Human2.02104628
20EBNA1_20929547_Chip-Seq_RAJI-cells_Human2.01067552
21ETV1_20927104_ChIP-Seq_GIST48_Human1.99840564
22TAF15_26573619_Chip-Seq_HEK293_Human1.97009173
23CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.96449122
24RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.95269914
25PHF8_20622853_ChIP-Seq_HELA_Human1.95046240
26NANOG_20526341_ChIP-Seq_ESCs_Human1.93583450
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92170178
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91543198
29GATA6_21074721_ChIP-Seq_CACO-2_Human1.90229326
30AUTS2_25519132_ChIP-Seq_293T-REX_Human1.88341396
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.86206645
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.84881235
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84881235
34NFYB_21822215_ChIP-Seq_K562_Human1.83573469
35GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.72809695
36PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.69473546
37ELF1_20517297_ChIP-Seq_JURKAT_Human1.69347412
38BCL6_27268052_Chip-Seq_Bcells_Human1.68722667
39ERA_21632823_ChIP-Seq_H3396_Human1.66480867
40YY1_22570637_ChIP-Seq_MALME-3M_Human1.62172599
41ETV2_25802403_ChIP-Seq_MESCs_Mouse1.58192141
42BCOR_27268052_Chip-Seq_Bcells_Human1.57993288
43ZNF274_21170338_ChIP-Seq_K562_Hela1.57714113
44PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.57396916
45NFYA_21822215_ChIP-Seq_K562_Human1.57323349
46E2F1_20622854_ChIP-Seq_HELA_Human1.56613954
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51335829
48TAF2_19829295_ChIP-Seq_ESCs_Human1.50002607
49ERG_20517297_ChIP-Seq_VCAP_Human1.49852985
50TBL1_22424771_ChIP-Seq_293T_Human1.48968295
51KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.46040070
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45794618
53RUNX_20019798_ChIP-Seq_JUKART_Human1.44711222
54GATA2_19941826_ChIP-Seq_K562_Human1.43319494
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41223790
56SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.39351653
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39309735
58EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.38255242
59TDRD3_21172665_ChIP-Seq_MCF-7_Human1.38219684
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.37341299
61MYC_19829295_ChIP-Seq_ESCs_Human1.36464811
62CTCF_20526341_ChIP-Seq_ESCs_Human1.35290607
63SMRT_27268052_Chip-Seq_Bcells_Human1.34660422
64FOXH1_21741376_ChIP-Seq_ESCs_Human1.33519424
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.33101278
66P300_19829295_ChIP-Seq_ESCs_Human1.32864046
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32699165
68P53_21459846_ChIP-Seq_SAOS-2_Human1.31743784
69SALL4_22934838_ChIP-ChIP_CD34+_Human1.31000599
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.30382745
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.30126091
72AR_25329375_ChIP-Seq_VCAP_Human1.28416192
73RAC3_21632823_ChIP-Seq_H3396_Human1.27442526
74GABP_17652178_ChIP-ChIP_JURKAT_Human1.23542098
75NANOG_19829295_ChIP-Seq_ESCs_Human1.21586770
76SOX2_19829295_ChIP-Seq_ESCs_Human1.21586770
77WDR5_24793694_ChIP-Seq_LNCAP_Human1.20912717
78PHF8_20622854_ChIP-Seq_HELA_Human1.20290310
79CTCF_27219007_Chip-Seq_Bcells_Human1.18866364
80P300_27268052_Chip-Seq_Bcells_Human1.13466868
81SMAD3_21741376_ChIP-Seq_ESCs_Human1.13254206
82EZH2_22144423_ChIP-Seq_EOC_Human1.12098655
83CTCF_21964334_Chip-Seq_Bcells_Human1.12088480
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09830855
85HOXB7_26014856_ChIP-Seq_BT474_Human1.07370941
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06832058
87FOXH1_21741376_ChIP-Seq_EPCs_Human1.05886795
88AR_21572438_ChIP-Seq_LNCaP_Human1.05874359
89GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05180733
90RUNX2_22187159_ChIP-Seq_PCA_Human1.04551664
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.04401794
92SA1_27219007_Chip-Seq_Bcells_Human1.04156686
93SMAD4_21741376_ChIP-Seq_HESCs_Human1.03927501
94CEBPB_22108803_ChIP-Seq_LS180_Human1.03774123
95OCT4_20526341_ChIP-Seq_ESCs_Human1.03010544
96P68_20966046_ChIP-Seq_HELA_Human1.01129756
97SOX2_22085726_ChIP-Seq_NPCs_Mouse1.01058171
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00673132
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98143907
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96632017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.22800493
2MP0003878_abnormal_ear_physiology6.38551200
3MP0005377_hearing/vestibular/ear_phenot6.38551200
4MP0001348_abnormal_lacrimal_gland4.82473237
5MP0000015_abnormal_ear_pigmentation3.70718570
6MP0003718_maternal_effect2.80222891
7MP0005670_abnormal_white_adipose2.75801581
8MP0003698_abnormal_male_reproductive2.74281310
9MP0003646_muscle_fatigue2.70780261
10MP0001929_abnormal_gametogenesis2.31663605
11MP0001873_stomach_inflammation2.21024001
12MP0004742_abnormal_vestibular_system2.14756565
13MP0004147_increased_porphyrin_level1.98971853
14MP0002132_abnormal_respiratory_system1.80284472
15MP0003879_abnormal_hair_cell1.78748300
16MP0005310_abnormal_salivary_gland1.72126204
17MP0002234_abnormal_pharynx_morphology1.66523853
18MP0008875_abnormal_xenobiotic_pharmacok1.66058893
19MP0004233_abnormal_muscle_weight1.65901646
20MP0005397_hematopoietic_system_phenotyp1.64242428
21MP0001545_abnormal_hematopoietic_system1.64242428
22MP0005636_abnormal_mineral_homeostasis1.55871578
23MP0001968_abnormal_touch/_nociception1.48306131
24MP0002653_abnormal_ependyma_morphology1.41706636
25MP0004885_abnormal_endolymph1.37971449
26MP0002161_abnormal_fertility/fecundity1.36956719
27MP0001984_abnormal_olfaction1.27374435
28MP0005646_abnormal_pituitary_gland1.27038953
29MP0005379_endocrine/exocrine_gland_phen1.26292950
30MP0008872_abnormal_physiological_respon1.25156718
31MP0000678_abnormal_parathyroid_gland1.23534979
32MP0002095_abnormal_skin_pigmentation1.18543951
33MP0005451_abnormal_body_composition1.18164836
34MP0001324_abnormal_eye_pigmentation1.11815110
35MP0002735_abnormal_chemical_nociception1.11655759
36MP0003959_abnormal_lean_body1.10199875
37MP0002210_abnormal_sex_determination1.08388237
38MP0003567_abnormal_fetal_cardiomyocyte1.02864045
39MP0004085_abnormal_heartbeat1.02153115
40MP0005551_abnormal_eye_electrophysiolog1.02126511
41MP0001765_abnormal_ion_homeostasis1.01423885
42MP0003186_abnormal_redox_activity1.01113665
43MP0005395_other_phenotype1.00923012
44MP0003136_yellow_coat_color0.99837273
45MP0008995_early_reproductive_senescence0.99133570
46MP0005083_abnormal_biliary_tract0.98902217
47MP0001486_abnormal_startle_reflex0.97851675
48MP0001881_abnormal_mammary_gland0.97639369
49MP0002138_abnormal_hepatobiliary_system0.94213339
50MP0001485_abnormal_pinna_reflex0.93857639
51MP0009278_abnormal_bone_marrow0.90661050
52MP0001440_abnormal_grooming_behavior0.90348166
53MP0003656_abnormal_erythrocyte_physiolo0.87735857
54MP0001664_abnormal_digestion0.87142800
55MP0000371_diluted_coat_color0.86374766
56MP0003303_peritoneal_inflammation0.85734075
57MP0003011_delayed_dark_adaptation0.84623498
58MP0002127_abnormal_cardiovascular_syste0.83494828
59MP0001764_abnormal_homeostasis0.83309580
60MP0008058_abnormal_DNA_repair0.82472786
61MP0001963_abnormal_hearing_physiology0.77841714
62MP0000534_abnormal_ureter_morphology0.77511290
63MP0000465_gastrointestinal_hemorrhage0.76202961
64MP0002229_neurodegeneration0.74112667
65MP0000026_abnormal_inner_ear0.73703933
66MP0000653_abnormal_sex_gland0.72077044
67MP0002837_dystrophic_cardiac_calcinosis0.70546883
68MP0004142_abnormal_muscle_tone0.69141630
69MP0001145_abnormal_male_reproductive0.68650571
70MP0002557_abnormal_social/conspecific_i0.68376847
71MP0006054_spinal_hemorrhage0.65601681
72MP0001905_abnormal_dopamine_level0.64693865
73MP0002006_tumorigenesis0.64590327
74MP0002067_abnormal_sensory_capabilities0.64407026
75MP0004957_abnormal_blastocyst_morpholog0.64081033
76MP0006292_abnormal_olfactory_placode0.63911507
77MP0008961_abnormal_basal_metabolism0.63688969
78MP0002751_abnormal_autonomic_nervous0.62363405
79MP0002272_abnormal_nervous_system0.61815167
80MP0005671_abnormal_response_to0.61622058
81MP0003828_pulmonary_edema0.60781166
82MP0001293_anophthalmia0.56435656
83MP0000372_irregular_coat_pigmentation0.55633693
84MP0005423_abnormal_somatic_nervous0.55030534
85MP0001299_abnormal_eye_distance/0.53467677
86MP0001188_hyperpigmentation0.50401750
87MP0005645_abnormal_hypothalamus_physiol0.49110700
88MP0004510_myositis0.48395166
89MP0002166_altered_tumor_susceptibility0.48009210
90MP0000313_abnormal_cell_death0.47526904
91MP0003693_abnormal_embryo_hatching0.47100815
92MP0001835_abnormal_antigen_presentation0.46770532
93MP0002160_abnormal_reproductive_system0.46638233
94MP0005166_decreased_susceptibility_to0.46025754
95MP0000470_abnormal_stomach_morphology0.45270005
96MP0000681_abnormal_thyroid_gland0.45265725
97MP0002733_abnormal_thermal_nociception0.42063567
98MP0002736_abnormal_nociception_after0.40377034
99MP0003950_abnormal_plasma_membrane0.40108283
100MP0003936_abnormal_reproductive_system0.39748395

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hemoglobin (HP:0011902)8.00425322
2Abnormality of the heme biosynthetic pathway (HP:0010472)7.38720582
3Abnormality of macular pigmentation (HP:0008002)7.18565689
4Severe visual impairment (HP:0001141)5.33884271
5Gastrointestinal infarctions (HP:0005244)4.67112176
6Albinism (HP:0001022)4.42515099
7Abnormal rod and cone electroretinograms (HP:0008323)4.14257033
8Reduced antithrombin III activity (HP:0001976)4.01529987
9Attenuation of retinal blood vessels (HP:0007843)4.01116166
10Cone-rod dystrophy (HP:0000548)3.94031507
11Bony spicule pigmentary retinopathy (HP:0007737)3.71294107
12Microcytic anemia (HP:0001935)3.49985926
13Fatigue (HP:0012378)3.37975629
14Central scotoma (HP:0000603)3.33306573
15Nasal polyposis (HP:0100582)3.32265986
16Thoracolumbar scoliosis (HP:0002944)3.17771226
17Acute necrotizing encephalopathy (HP:0006965)3.13130444
18Decreased central vision (HP:0007663)3.02778056
19Absent/shortened dynein arms (HP:0200106)3.00192719
20Dynein arm defect of respiratory motile cilia (HP:0012255)3.00192719
21Homocystinuria (HP:0002156)2.90041032
22Abnormality of homocysteine metabolism (HP:0010919)2.90041032
23Exertional dyspnea (HP:0002875)2.87518300
24Chronic hepatic failure (HP:0100626)2.86585040
25Peritonitis (HP:0002586)2.84757691
26Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.81278971
27Rectal prolapse (HP:0002035)2.78278477
28Aplasia/Hypoplasia of the earlobes (HP:0009906)2.74891785
29Pallor (HP:0000980)2.72015130
30Abnormal mitochondria in muscle tissue (HP:0008316)2.63915999
31Acute encephalopathy (HP:0006846)2.61350413
32Abnormal respiratory motile cilium morphology (HP:0005938)2.60269079
33Abnormal respiratory epithelium morphology (HP:0012253)2.60269079
34Scotoma (HP:0000575)2.58833666
35Renal Fanconi syndrome (HP:0001994)2.58611929
36Dyschromatopsia (HP:0007641)2.57579165
37Enlarged epiphyses (HP:0010580)2.54947147
38Macular degeneration (HP:0000608)2.54220547
39Portal hypertension (HP:0001409)2.53088527
40Abnormality of the nasal mucosa (HP:0000433)2.52662011
41Facial hemangioma (HP:0000329)2.52260803
42Abnormal respiratory motile cilium physiology (HP:0012261)2.51402574
43Abnormality of sulfur amino acid metabolism (HP:0004339)2.46611030
44Self-mutilation (HP:0000742)2.43720545
45Abnormal ciliary motility (HP:0012262)2.41811837
46Muscle fiber atrophy (HP:0100295)2.41316868
47Hyperthyroidism (HP:0000836)2.40139624
48Progressive macrocephaly (HP:0004481)2.39096656
49Tetany (HP:0001281)2.37956775
50Nephronophthisis (HP:0000090)2.37375693
51Type 2 muscle fiber atrophy (HP:0003554)2.36950687
52Reticulocytosis (HP:0001923)2.36327808
53Bell-shaped thorax (HP:0001591)2.34584614
54Abnormality of dental color (HP:0011073)2.30946948
55Generalized hypopigmentation (HP:0007513)2.28843454
56Anencephaly (HP:0002323)2.28176578
57Abnormality of the hepatic vasculature (HP:0006707)2.26885388
58Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.24257163
59Hyperkalemia (HP:0002153)2.23296743
60Infertility (HP:0000789)2.20971647
61Abnormality of DNA repair (HP:0003254)2.15896240
62Facial shape deformation (HP:0011334)2.14874102
63Potter facies (HP:0002009)2.14874102
64Asymmetric septal hypertrophy (HP:0001670)2.14233626
65Generalized aminoaciduria (HP:0002909)2.13175688
66Unilateral renal agenesis (HP:0000122)2.11976707
67Optic disc pallor (HP:0000543)2.06172047
68Resting tremor (HP:0002322)2.03721042
69Hypochromic microcytic anemia (HP:0004840)2.03710632
703-Methylglutaconic aciduria (HP:0003535)2.03684331
71Azoospermia (HP:0000027)2.03235370
72Large for gestational age (HP:0001520)1.99113125
73Male infertility (HP:0003251)1.98789311
74Ocular albinism (HP:0001107)1.96955390
75Hypoplastic ischia (HP:0003175)1.96791229
76Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.96139752
77Spontaneous abortion (HP:0005268)1.96116268
78Tubulointerstitial nephritis (HP:0001970)1.89474967
79Degeneration of anterior horn cells (HP:0002398)1.89331433
80Abnormality of the anterior horn cell (HP:0006802)1.89331433
81Microretrognathia (HP:0000308)1.89138889
82Abnormality of the renal medulla (HP:0100957)1.86688479
83Photophobia (HP:0000613)1.85885011
84Mitochondrial inheritance (HP:0001427)1.84912560
85Abnormality of the neuromuscular junction (HP:0003398)1.83357587
86Fatigable weakness (HP:0003473)1.83357587
87Congenital stationary night blindness (HP:0007642)1.79416743
88Abnormal spermatogenesis (HP:0008669)1.78772561
89Abnormality of the columella (HP:0009929)1.77601258
90Spastic paraparesis (HP:0002313)1.75825881
91Occipital encephalocele (HP:0002085)1.75727971
92Capillary hemangiomas (HP:0005306)1.75265085
93Iris hypopigmentation (HP:0007730)1.74573321
94Abnormal urine output (HP:0012590)1.73386120
95Thoracic kyphosis (HP:0002942)1.73365084
96Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73342372
97Abnormal protein N-linked glycosylation (HP:0012347)1.73342372
98Abnormal protein glycosylation (HP:0012346)1.73342372
99Abnormal glycosylation (HP:0012345)1.73342372
100Pancreatic cysts (HP:0001737)1.73129993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK45.15378385
2EIF2AK14.71778198
3PBK3.88330371
4TSSK63.83510102
5DDR23.65420652
6MAP4K22.83777660
7INSRR2.73859599
8TESK12.71261079
9BRD41.94382146
10DAPK21.93365622
11TNIK1.89665358
12DYRK31.87393833
13WNK11.87148837
14PRKD31.86790766
15AKT31.80580324
16RPS6KA21.71662018
17TRPM71.71088304
18JAK31.63248316
19PLK21.61043300
20PNCK1.60493046
21RPS6KL11.53081241
22RPS6KC11.53081241
23PDK21.46413000
24RPS6KA61.41358018
25ABL21.39466296
26TRIM281.31965501
27VRK21.31128187
28RIPK11.30809077
29TXK1.28593358
30TIE11.27184257
31PIK3CG1.26138423
32PRKG21.17502963
33ADRBK21.16742744
34STK41.14814953
35MAPK151.03075550
36NUAK10.97176314
37IKBKB0.96760042
38TAF10.96487660
39RPS6KA10.95022450
40SRPK10.87394536
41MAP3K80.87253964
42RIPK40.84900719
43CCNB10.83893656
44STK38L0.81554247
45TAOK30.79314906
46BMPR20.77509402
47KSR20.77476407
48BRAF0.74086438
49FLT30.69662944
50CAMK1G0.69016225
51DYRK1B0.68425885
52MAPK130.67811458
53STK390.65817837
54RPS6KA50.63807607
55DAPK10.62734558
56STK100.62477533
57BMPR1B0.61638631
58CHUK0.60602382
59ROCK20.58163140
60WNK40.57026743
61EIF2AK30.54792813
62DMPK0.52815244
63MET0.52628373
64MAPK100.51507995
65CDK70.51412936
66MKNK10.51047754
67UHMK10.50043525
68MAP2K20.50027742
69STK380.49488546
70PRKG10.49242056
71PDK10.49040526
72PRKCQ0.48073556
73ADRBK10.46997817
74DAPK30.44847100
75MAPK110.44753628
76MKNK20.44737175
77CAMK40.43946531
78WNK30.41296682
79ROCK10.40968315
80PDPK10.40732009
81MUSK0.40400089
82MST1R0.40165750
83CAMK2A0.38558588
84PKN10.36517895
85NME10.35332690
86TLK10.33361727
87CAMK10.29907093
88MAP3K20.29770787
89VRK10.27808966
90SGK10.27425386
91MAPKAPK50.27285440
92MAP3K40.26272345
93MAP4K10.26033396
94STK160.25742452
95PTK2B0.24856520
96CSNK2A20.24840483
97SGK30.24413372
98ZAK0.24193010
99CDK80.23985207
100OXSR10.23925366

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005634.89755474
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.63125835
3Allograft rejection_Homo sapiens_hsa053304.10918528
4Autoimmune thyroid disease_Homo sapiens_hsa053203.87395053
5Asthma_Homo sapiens_hsa053102.98263363
6Selenocompound metabolism_Homo sapiens_hsa004502.82845616
7Olfactory transduction_Homo sapiens_hsa047402.66393771
8Proteasome_Homo sapiens_hsa030502.43369669
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.13227872
10Type I diabetes mellitus_Homo sapiens_hsa049401.83893756
11One carbon pool by folate_Homo sapiens_hsa006701.79624552
12Basal transcription factors_Homo sapiens_hsa030221.75162653
13Huntingtons disease_Homo sapiens_hsa050161.70328388
14Graft-versus-host disease_Homo sapiens_hsa053321.69228567
15Nicotine addiction_Homo sapiens_hsa050331.59757495
16Butanoate metabolism_Homo sapiens_hsa006501.56052408
17Fatty acid biosynthesis_Homo sapiens_hsa000611.55950552
18Cardiac muscle contraction_Homo sapiens_hsa042601.50682104
19Dorso-ventral axis formation_Homo sapiens_hsa043201.49234734
20Antigen processing and presentation_Homo sapiens_hsa046121.45692044
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.42559717
22Oxidative phosphorylation_Homo sapiens_hsa001901.41039883
23RNA transport_Homo sapiens_hsa030131.39509013
24Ribosome_Homo sapiens_hsa030101.36123662
25Arginine and proline metabolism_Homo sapiens_hsa003301.32404983
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29232893
27Adipocytokine signaling pathway_Homo sapiens_hsa049201.28452806
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.22500062
29Caffeine metabolism_Homo sapiens_hsa002321.21847317
30Base excision repair_Homo sapiens_hsa034101.20529374
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.20077523
32Measles_Homo sapiens_hsa051621.19090861
33Parkinsons disease_Homo sapiens_hsa050121.13603549
34Fatty acid elongation_Homo sapiens_hsa000621.12938752
35Phototransduction_Homo sapiens_hsa047441.12641871
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07069698
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03967895
38Morphine addiction_Homo sapiens_hsa050320.97107536
39Hematopoietic cell lineage_Homo sapiens_hsa046400.96132518
40Jak-STAT signaling pathway_Homo sapiens_hsa046300.89757029
41Salivary secretion_Homo sapiens_hsa049700.89692079
42Thyroid cancer_Homo sapiens_hsa052160.89420157
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89148912
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89062043
45Malaria_Homo sapiens_hsa051440.88533669
46T cell receptor signaling pathway_Homo sapiens_hsa046600.87963091
47Fat digestion and absorption_Homo sapiens_hsa049750.85631907
48Taste transduction_Homo sapiens_hsa047420.83623361
49Viral myocarditis_Homo sapiens_hsa054160.83217671
50mRNA surveillance pathway_Homo sapiens_hsa030150.81355860
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.79264045
52Linoleic acid metabolism_Homo sapiens_hsa005910.78678413
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77560427
54GABAergic synapse_Homo sapiens_hsa047270.77037529
55N-Glycan biosynthesis_Homo sapiens_hsa005100.73572220
56RNA polymerase_Homo sapiens_hsa030200.72907397
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70775192
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68014318
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67468440
60Mineral absorption_Homo sapiens_hsa049780.67299844
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64553704
62RNA degradation_Homo sapiens_hsa030180.64051556
63Tyrosine metabolism_Homo sapiens_hsa003500.63114927
64Metabolic pathways_Homo sapiens_hsa011000.61122695
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58718194
66Non-homologous end-joining_Homo sapiens_hsa034500.58315638
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56988419
68Ovarian steroidogenesis_Homo sapiens_hsa049130.55790289
69Fatty acid degradation_Homo sapiens_hsa000710.55376300
70Retinol metabolism_Homo sapiens_hsa008300.54640304
71Ether lipid metabolism_Homo sapiens_hsa005650.53737134
72Influenza A_Homo sapiens_hsa051640.53582425
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52344544
74Nucleotide excision repair_Homo sapiens_hsa034200.48533408
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43260281
76Synaptic vesicle cycle_Homo sapiens_hsa047210.42198173
77Carbon metabolism_Homo sapiens_hsa012000.41694038
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41479971
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40784179
80ABC transporters_Homo sapiens_hsa020100.40759429
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40584954
82Purine metabolism_Homo sapiens_hsa002300.37909836
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37817149
84Leishmaniasis_Homo sapiens_hsa051400.37207590
85Alzheimers disease_Homo sapiens_hsa050100.36184663
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35331387
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33625739
88Herpes simplex infection_Homo sapiens_hsa051680.33608424
89Circadian entrainment_Homo sapiens_hsa047130.31665031
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31001686
91Nitrogen metabolism_Homo sapiens_hsa009100.30808023
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30187383
93Protein digestion and absorption_Homo sapiens_hsa049740.29650536
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29591287
95Fanconi anemia pathway_Homo sapiens_hsa034600.28983331
96Chemokine signaling pathway_Homo sapiens_hsa040620.28601322
97Starch and sucrose metabolism_Homo sapiens_hsa005000.28474703
98PPAR signaling pathway_Homo sapiens_hsa033200.27634691
99Epstein-Barr virus infection_Homo sapiens_hsa051690.26413817
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26186197

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