PSMA2P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.34601486
2DNA deamination (GO:0045006)4.82065766
3water-soluble vitamin biosynthetic process (GO:0042364)4.60775955
4regulation of chronic inflammatory response (GO:0002676)4.54747867
5DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.51278254
6signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.42162060
7signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.42162060
8signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.42162060
9signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.40686967
10intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.40686967
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.37240021
12regulation of cellular amino acid metabolic process (GO:0006521)4.36016583
13signal transduction involved in cell cycle checkpoint (GO:0072395)4.29077892
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.18286116
15signal transduction involved in DNA damage checkpoint (GO:0072422)4.18030627
16signal transduction involved in DNA integrity checkpoint (GO:0072401)4.18030627
17positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.12415971
18cilium or flagellum-dependent cell motility (GO:0001539)4.10804097
19regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.03207369
20DNA replication-dependent nucleosome assembly (GO:0006335)3.91537219
21DNA replication-dependent nucleosome organization (GO:0034723)3.91537219
22rRNA modification (GO:0000154)3.88556254
23RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.87467352
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.83760586
25negative regulation of ligase activity (GO:0051352)3.83760586
26rRNA methylation (GO:0031167)3.81653897
27chaperone-mediated protein transport (GO:0072321)3.80866839
28retinal cone cell development (GO:0046549)3.72707123
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.72384561
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.72370368
31maturation of 5.8S rRNA (GO:0000460)3.72170747
32exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.61075077
33nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.59290483
34energy coupled proton transport, down electrochemical gradient (GO:0015985)3.57853100
35ATP synthesis coupled proton transport (GO:0015986)3.57853100
36transcription from mitochondrial promoter (GO:0006390)3.56938376
37negative regulation of telomere maintenance (GO:0032205)3.55281591
38pyrimidine nucleobase catabolic process (GO:0006208)3.51103505
39DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.49224242
40positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.45709985
41DNA damage response, detection of DNA damage (GO:0042769)3.43632707
42mitochondrial RNA metabolic process (GO:0000959)3.39720310
43protein deneddylation (GO:0000338)3.38410203
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.36684885
45neural tube formation (GO:0001841)3.36382608
46positive regulation of ligase activity (GO:0051351)3.28874334
47lactate metabolic process (GO:0006089)3.26719397
48cullin deneddylation (GO:0010388)3.25836539
49termination of RNA polymerase I transcription (GO:0006363)3.22236847
50positive regulation of cell cycle arrest (GO:0071158)3.21981244
51regulation of cellular amine metabolic process (GO:0033238)3.18190762
52DNA catabolic process, exonucleolytic (GO:0000738)3.15923003
53glial cell proliferation (GO:0014009)3.15214691
54DNA replication checkpoint (GO:0000076)3.15000384
55organelle disassembly (GO:1903008)3.11823664
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.09776045
57limb bud formation (GO:0060174)3.09037181
58ubiquinone biosynthetic process (GO:0006744)3.03194585
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.02816429
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.02816429
61transcription initiation from RNA polymerase I promoter (GO:0006361)3.01574604
62transcription elongation from RNA polymerase I promoter (GO:0006362)2.95960642
63regulation of helicase activity (GO:0051095)2.95927103
64signal transduction in response to DNA damage (GO:0042770)2.93260213
65transcription from RNA polymerase I promoter (GO:0006360)2.89304998
66regulation of ubiquitin-protein transferase activity (GO:0051438)2.88785409
67DNA double-strand break processing (GO:0000729)2.88778382
68telomere maintenance via telomerase (GO:0007004)2.87911783
69single strand break repair (GO:0000012)2.86444098
70antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.86360449
71pseudouridine synthesis (GO:0001522)2.85684206
72ubiquinone metabolic process (GO:0006743)2.80862373
73regulation of ligase activity (GO:0051340)2.77127265
74negative regulation of protein ubiquitination (GO:0031397)2.74745388
75protein neddylation (GO:0045116)2.74525132
76regulation of nuclear cell cycle DNA replication (GO:0033262)2.73036342
77ribosome assembly (GO:0042255)2.72991929
78nucleobase catabolic process (GO:0046113)2.72914546
79epithelial cilium movement (GO:0003351)2.72907424
80protein complex biogenesis (GO:0070271)2.72692066
81L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.69153670
82regulation of MHC class II biosynthetic process (GO:0045346)2.69097288
83S-adenosylmethionine metabolic process (GO:0046500)2.68671104
84indolalkylamine metabolic process (GO:0006586)2.68624750
85negative regulation of cell cycle G1/S phase transition (GO:1902807)2.68219813
86negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.68219813
87respiratory chain complex IV assembly (GO:0008535)2.67769275
88regulation of cell cycle arrest (GO:0071156)2.65816798
89cytochrome complex assembly (GO:0017004)2.64613517
90axoneme assembly (GO:0035082)2.64462449
91mitochondrial respiratory chain complex assembly (GO:0033108)2.63831172
92kidney morphogenesis (GO:0060993)2.62836259
93cilium movement (GO:0003341)2.62514516
94aldehyde catabolic process (GO:0046185)2.59287650
95CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.58690109
96electron transport chain (GO:0022900)2.58505299
97methionine biosynthetic process (GO:0009086)2.58278551
98kynurenine metabolic process (GO:0070189)2.58225389
99ribosome biogenesis (GO:0042254)2.57945110
100respiratory electron transport chain (GO:0022904)2.57780068

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.92368057
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.33315797
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.12032376
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.11923443
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.12522895
6ZNF274_21170338_ChIP-Seq_K562_Hela2.96198312
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.92190050
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82550281
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.70790046
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.67499958
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.65253341
12VDR_22108803_ChIP-Seq_LS180_Human2.60540374
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44150904
14VDR_23849224_ChIP-Seq_CD4+_Human2.33334934
15EWS_26573619_Chip-Seq_HEK293_Human2.32325262
16IGF1R_20145208_ChIP-Seq_DFB_Human2.17160347
17FOXP3_21729870_ChIP-Seq_TREG_Human2.12409148
18ELK1_19687146_ChIP-ChIP_HELA_Human2.12008636
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.11523667
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.06613726
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03889301
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.90209279
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90195836
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89142060
25FUS_26573619_Chip-Seq_HEK293_Human1.87088165
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.84794042
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76105312
28P300_19829295_ChIP-Seq_ESCs_Human1.66640751
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63082219
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.59770333
31DCP1A_22483619_ChIP-Seq_HELA_Human1.56081540
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55009290
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53993062
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51090798
35IRF1_19129219_ChIP-ChIP_H3396_Human1.50836237
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48337048
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45266793
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45042332
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44125413
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42702377
41TAF15_26573619_Chip-Seq_HEK293_Human1.42543097
42MYC_18940864_ChIP-ChIP_HL60_Human1.41788007
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.40517052
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40428493
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40402162
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40399288
47E2F7_22180533_ChIP-Seq_HELA_Human1.39377174
48GABP_19822575_ChIP-Seq_HepG2_Human1.35717910
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31397428
50TCF4_22108803_ChIP-Seq_LS180_Human1.27711822
51ER_23166858_ChIP-Seq_MCF-7_Human1.27676626
52TP53_22573176_ChIP-Seq_HFKS_Human1.27078708
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26993468
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26904666
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.24060187
56SOX2_19829295_ChIP-Seq_ESCs_Human1.22846102
57NANOG_19829295_ChIP-Seq_ESCs_Human1.22846102
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22804342
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20848066
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19566863
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15697840
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15371984
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15289317
64CBP_20019798_ChIP-Seq_JUKART_Human1.15289317
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12673313
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12622624
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12150075
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11227633
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08638839
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07032248
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06909558
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06772739
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.06772739
74AR_20517297_ChIP-Seq_VCAP_Human1.06538767
75SALL4_22934838_ChIP-ChIP_CD34+_Human1.05984371
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03883593
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02426011
78EZH2_22144423_ChIP-Seq_EOC_Human1.02100511
79FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01350391
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00628940
81E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99812748
82FOXH1_21741376_ChIP-Seq_EPCs_Human0.98368834
83HOXB7_26014856_ChIP-Seq_BT474_Human0.97934049
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97843968
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95072015
86EZH2_27294783_Chip-Seq_NPCs_Mouse0.92568770
87TTF2_22483619_ChIP-Seq_HELA_Human0.92516913
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92327994
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92188816
90GATA3_21878914_ChIP-Seq_MCF-7_Human0.91949413
91FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90862121
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90607902
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90200882
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89073977
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89041362
96ERG_20517297_ChIP-Seq_VCAP_Human0.88367842
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88346924
98KDM5A_27292631_Chip-Seq_BREAST_Human0.88159168
99GATA3_26560356_Chip-Seq_TH2_Human0.87670985
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87429721

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.43320645
2MP0008057_abnormal_DNA_replication3.35890052
3MP0008058_abnormal_DNA_repair3.31464664
4MP0002234_abnormal_pharynx_morphology3.22988011
5MP0001348_abnormal_lacrimal_gland3.22981493
6MP0008875_abnormal_xenobiotic_pharmacok2.92096626
7MP0002837_dystrophic_cardiac_calcinosis2.72757220
8MP0003646_muscle_fatigue2.67377941
9MP0003718_maternal_effect2.29865554
10MP0006036_abnormal_mitochondrial_physio2.17632505
11MP0008872_abnormal_physiological_respon2.17404317
12MP0003195_calcinosis2.01072062
13MP0003950_abnormal_plasma_membrane1.97533158
14MP0005551_abnormal_eye_electrophysiolog1.90969021
15MP0008995_early_reproductive_senescence1.84969559
16MP0001873_stomach_inflammation1.84747192
17MP0004145_abnormal_muscle_electrophysio1.82917862
18MP0001188_hyperpigmentation1.81017556
19MP0002751_abnormal_autonomic_nervous1.79749513
20MP0006035_abnormal_mitochondrial_morpho1.78802192
21MP0001984_abnormal_olfaction1.75867494
22MP0002653_abnormal_ependyma_morphology1.71471876
23MP0004957_abnormal_blastocyst_morpholog1.69160741
24MP0005253_abnormal_eye_physiology1.69007243
25MP0003890_abnormal_embryonic-extraembry1.68721857
26MP0001835_abnormal_antigen_presentation1.66548277
27MP0003786_premature_aging1.59303589
28MP0003787_abnormal_imprinting1.57479756
29MP0001501_abnormal_sleep_pattern1.56434069
30MP0002736_abnormal_nociception_after1.53676307
31MP0008877_abnormal_DNA_methylation1.51222116
32MP0006292_abnormal_olfactory_placode1.45248927
33MP0001529_abnormal_vocalization1.44993646
34MP0001905_abnormal_dopamine_level1.44268032
35MP0000685_abnormal_immune_system1.42323700
36MP0003011_delayed_dark_adaptation1.42068568
37MP0008789_abnormal_olfactory_epithelium1.41916950
38MP0001968_abnormal_touch/_nociception1.30579805
39MP0008775_abnormal_heart_ventricle1.28987433
40MP0002138_abnormal_hepatobiliary_system1.24371411
41MP0001764_abnormal_homeostasis1.22601576
42MP0006072_abnormal_retinal_apoptosis1.21586679
43MP0003567_abnormal_fetal_cardiomyocyte1.21538264
44MP0002277_abnormal_respiratory_mucosa1.21079801
45MP0005084_abnormal_gallbladder_morpholo1.19844974
46MP0004084_abnormal_cardiac_muscle1.16728270
47MP0009764_decreased_sensitivity_to1.16015756
48MP0009785_altered_susceptibility_to1.15927760
49MP0001293_anophthalmia1.15842664
50MP0005423_abnormal_somatic_nervous1.15825998
51MP0006082_CNS_inflammation1.13184612
52MP0003119_abnormal_digestive_system1.10168023
53MP0003111_abnormal_nucleus_morphology1.10034030
54MP0002272_abnormal_nervous_system1.08864890
55MP0010094_abnormal_chromosome_stability1.05878627
56MP0003693_abnormal_embryo_hatching1.03064646
57MP0005395_other_phenotype1.01061666
58MP0001286_abnormal_eye_development0.99424285
59MP0005410_abnormal_fertilization0.98028226
60MP0003137_abnormal_impulse_conducting0.96689373
61MP0005266_abnormal_metabolism0.94519473
62MP0003077_abnormal_cell_cycle0.93686038
63MP0005075_abnormal_melanosome_morpholog0.93405493
64MP0005085_abnormal_gallbladder_physiolo0.92835058
65MP0002254_reproductive_system_inflammat0.91172551
66MP0000427_abnormal_hair_cycle0.89377563
67MP0002282_abnormal_trachea_morphology0.86385443
68MP0005671_abnormal_response_to0.85940749
69MP0005499_abnormal_olfactory_system0.85273738
70MP0005394_taste/olfaction_phenotype0.85273738
71MP0000613_abnormal_salivary_gland0.85028117
72MP0004142_abnormal_muscle_tone0.84082214
73MP0002090_abnormal_vision0.83579717
74MP0002876_abnormal_thyroid_physiology0.82816809
75MP0002210_abnormal_sex_determination0.82202736
76MP0005195_abnormal_posterior_eye0.81239388
77MP0010386_abnormal_urinary_bladder0.81066226
78MP0000647_abnormal_sebaceous_gland0.79335731
79MP0003186_abnormal_redox_activity0.78395202
80MP0000049_abnormal_middle_ear0.78346531
81MP0001929_abnormal_gametogenesis0.77715730
82MP0004215_abnormal_myocardial_fiber0.77301748
83MP0002938_white_spotting0.77239227
84MP0002184_abnormal_innervation0.76492986
85MP0002148_abnormal_hypersensitivity_rea0.76297720
86MP0005645_abnormal_hypothalamus_physiol0.76004993
87MP0001346_abnormal_lacrimal_gland0.74661941
88MP0003938_abnormal_ear_development0.71628823
89MP0002752_abnormal_somatic_nervous0.71160472
90MP0002557_abnormal_social/conspecific_i0.70826631
91MP0009745_abnormal_behavioral_response0.70771604
92MP0004085_abnormal_heartbeat0.68727783
93MP0009046_muscle_twitch0.68273157
94MP0003121_genomic_imprinting0.66992927
95MP0010234_abnormal_vibrissa_follicle0.66036254
96MP0005636_abnormal_mineral_homeostasis0.65104365
97MP0001119_abnormal_female_reproductive0.64861886
98MP0004742_abnormal_vestibular_system0.64339135
99MP0003880_abnormal_central_pattern0.63675197
100MP0000653_abnormal_sex_gland0.62038477

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.28666895
2Abnormality of the labia minora (HP:0012880)3.95161583
3Acute encephalopathy (HP:0006846)3.80849149
4Dynein arm defect of respiratory motile cilia (HP:0012255)3.74130782
5Absent/shortened dynein arms (HP:0200106)3.74130782
6Increased CSF lactate (HP:0002490)3.64509850
7Progressive macrocephaly (HP:0004481)3.60205512
8Mitochondrial inheritance (HP:0001427)3.57080609
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.55461015
10Abnormal mitochondria in muscle tissue (HP:0008316)3.50895767
11Chronic bronchitis (HP:0004469)3.50562317
12Hepatocellular necrosis (HP:0001404)3.33206962
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.28098538
14Increased hepatocellular lipid droplets (HP:0006565)3.18815331
15Hepatic necrosis (HP:0002605)3.14535259
16Optic disc pallor (HP:0000543)3.06060147
17Methylmalonic acidemia (HP:0002912)2.98129786
18Molar tooth sign on MRI (HP:0002419)2.93908447
19Abnormality of midbrain morphology (HP:0002418)2.93908447
20Methylmalonic aciduria (HP:0012120)2.87933154
21Lipid accumulation in hepatocytes (HP:0006561)2.87535671
22Constricted visual fields (HP:0001133)2.85854494
23Cerebral edema (HP:0002181)2.83210680
24Hyperglycinemia (HP:0002154)2.83011771
25Increased serum lactate (HP:0002151)2.80520682
26Pancreatic cysts (HP:0001737)2.75906037
27Aplasia/Hypoplasia of the patella (HP:0006498)2.69265787
28Colon cancer (HP:0003003)2.67116047
29Abnormal rod and cone electroretinograms (HP:0008323)2.65992351
30Patellar aplasia (HP:0006443)2.64965126
31Abnormal respiratory motile cilium physiology (HP:0012261)2.53297330
32Retinal dysplasia (HP:0007973)2.47023556
33Lissencephaly (HP:0001339)2.43747078
34Abnormal respiratory epithelium morphology (HP:0012253)2.42310893
35Abnormal respiratory motile cilium morphology (HP:0005938)2.42310893
363-Methylglutaconic aciduria (HP:0003535)2.39256107
37Respiratory failure (HP:0002878)2.36741890
38Renal Fanconi syndrome (HP:0001994)2.36575695
39Large for gestational age (HP:0001520)2.36019541
40Abnormal ciliary motility (HP:0012262)2.35214315
41Hypomagnesemia (HP:0002917)2.31432428
42Abolished electroretinogram (ERG) (HP:0000550)2.31192232
43Pendular nystagmus (HP:0012043)2.28361691
44Lactic acidosis (HP:0003128)2.27197206
45Hyperglycinuria (HP:0003108)2.26491304
46Fibular aplasia (HP:0002990)2.25818319
47Rhinitis (HP:0012384)2.23790202
48Lethargy (HP:0001254)2.21966302
49Increased corneal curvature (HP:0100692)2.20969346
50Keratoconus (HP:0000563)2.20969346
51Type II lissencephaly (HP:0007260)2.16642337
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13040114
53Abnormality of serine family amino acid metabolism (HP:0010894)2.12782247
54Abnormality of glycine metabolism (HP:0010895)2.12782247
55CNS demyelination (HP:0007305)2.12145855
56Abnormality of the renal cortex (HP:0011035)2.11113916
57Inability to walk (HP:0002540)2.10638347
58Nephronophthisis (HP:0000090)2.10356959
59Pancreatic fibrosis (HP:0100732)2.09368922
60Aplasia/hypoplasia of the uterus (HP:0008684)2.09104868
61Generalized aminoaciduria (HP:0002909)2.08231869
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07645932
63True hermaphroditism (HP:0010459)2.05810915
64Abnormality of the vitamin B12 metabolism (HP:0004341)2.05194264
65Degeneration of anterior horn cells (HP:0002398)2.05075771
66Abnormality of the anterior horn cell (HP:0006802)2.05075771
67Cerebral hypomyelination (HP:0006808)2.04450646
68Abnormal hair whorl (HP:0010721)2.03264999
69Exertional dyspnea (HP:0002875)2.03060911
70Cellular immunodeficiency (HP:0005374)1.99739492
71Progressive inability to walk (HP:0002505)1.99409361
72Abnormality of serum amino acid levels (HP:0003112)1.98229965
73Decreased electroretinogram (ERG) amplitude (HP:0000654)1.94051420
74Homocystinuria (HP:0002156)1.93139420
75Abnormality of homocysteine metabolism (HP:0010919)1.93139420
76Polyuria (HP:0000103)1.91747180
77Exercise intolerance (HP:0003546)1.91643242
78Bronchitis (HP:0012387)1.91214956
79Abnormality of vitamin B metabolism (HP:0004340)1.89509527
80Hypochromic microcytic anemia (HP:0004840)1.88003619
81Chronic hepatic failure (HP:0100626)1.84247046
82Leukodystrophy (HP:0002415)1.80912805
83Attenuation of retinal blood vessels (HP:0007843)1.79277718
84Neoplasm of the adrenal gland (HP:0100631)1.79093483
85Congenital stationary night blindness (HP:0007642)1.78721410
86Blindness (HP:0000618)1.77588698
87Abnormality of the pons (HP:0007361)1.76618372
88Renal cortical cysts (HP:0000803)1.74655459
89Abnormality of the renal medulla (HP:0100957)1.74078301
90Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.70599412
91Adactyly (HP:0009776)1.70223784
92Increased intramyocellular lipid droplets (HP:0012240)1.70219463
93Type 2 muscle fiber atrophy (HP:0003554)1.69271640
94Delayed CNS myelination (HP:0002188)1.68689859
95Pachygyria (HP:0001302)1.66970089
96Aplasia/Hypoplasia of the ulna (HP:0006495)1.66181598
97Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.65621674
98Decreased activity of mitochondrial respiratory chain (HP:0008972)1.65621674
99X-linked dominant inheritance (HP:0001423)1.64491180
100Hyperalaninemia (HP:0003348)1.64059322

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.89419775
2SRPK13.46799978
3TSSK63.42700820
4EIF2AK12.87513643
5VRK22.83941242
6NUAK12.50272187
7STK162.47936750
8TAF12.47372659
9CASK2.44662522
10PBK2.43925566
11EIF2AK32.28632017
12MST42.21481649
13ZAK2.18390775
14BCR2.09372671
15MKNK22.08989140
16TLK12.03953144
17BUB11.95809354
18FRK1.92655723
19BMPR1B1.92168076
20CSNK1A1L1.85264909
21ADRBK21.85224727
22CSNK1G31.82879374
23WNK31.81776422
24CSNK1G11.65143798
25CSNK1G21.61064523
26MKNK11.60254633
27GRK11.60069335
28MAP3K91.57559031
29PLK31.55154492
30VRK11.53221687
31OXSR11.44284531
32MARK11.38645114
33PAK31.31394306
34DYRK21.28850988
35ERBB31.25124352
36BCKDK1.24659052
37SIK31.16464129
38NME11.15272575
39PINK11.12981883
40STK391.11073312
41DAPK11.09663641
42WNK41.04761448
43MAP3K41.00989580
44DYRK30.97150716
45EPHA30.94827997
46ACVR1B0.93729630
47PNCK0.90004940
48CDC70.89489117
49WEE10.87027205
50NEK10.84403662
51PDK20.80796877
52EIF2AK20.78153151
53INSRR0.76216694
54RAF10.75166263
55MINK10.72835562
56MAP2K70.72834740
57STK40.70258371
58PLK10.70006401
59TAOK30.66153304
60ALK0.57489418
61ATR0.57268083
62TIE10.56756073
63PRKCG0.53779451
64KIT0.52908688
65DAPK20.52765155
66MAPKAPK30.51602375
67NLK0.50190146
68TGFBR10.49592052
69PASK0.49015004
70PLK40.47037603
71CSNK2A10.42271852
72TNIK0.42078875
73FLT30.41979678
74GRK50.40895072
75MET0.40592122
76AURKA0.40174387
77TTK0.38918665
78MYLK0.37605659
79PAK10.36237698
80PAK60.33484668
81MAPK130.32668402
82PIK3CG0.32326284
83OBSCN0.31976383
84RPS6KA50.30788005
85MAP4K20.29817233
86CSNK1E0.29564100
87AURKB0.28461714
88CSNK1D0.27246086
89AKT30.26931749
90CSNK1A10.26855793
91MARK30.25217071
92CCNB10.25111231
93TXK0.24394853
94PRKCI0.23694706
95CSNK2A20.23219477
96STK38L0.22918116
97ADRBK10.22851582
98PLK20.22362427
99IKBKB0.21740823
100FGR0.20814977

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.47568271
2Protein export_Homo sapiens_hsa030602.75034860
3Oxidative phosphorylation_Homo sapiens_hsa001902.65163962
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.55136518
5Asthma_Homo sapiens_hsa053102.38069321
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23837850
7RNA polymerase_Homo sapiens_hsa030202.19380554
8Propanoate metabolism_Homo sapiens_hsa006402.12450585
9Parkinsons disease_Homo sapiens_hsa050122.12125214
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08881137
11One carbon pool by folate_Homo sapiens_hsa006702.04664302
12Basal transcription factors_Homo sapiens_hsa030222.03816568
13Homologous recombination_Homo sapiens_hsa034401.89591676
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79547320
15Huntingtons disease_Homo sapiens_hsa050161.77881854
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72921802
17RNA degradation_Homo sapiens_hsa030181.72469623
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72180794
19Fatty acid elongation_Homo sapiens_hsa000621.71391672
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.66592683
21Tryptophan metabolism_Homo sapiens_hsa003801.64437524
22DNA replication_Homo sapiens_hsa030301.60192128
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.54616506
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52580614
25Mismatch repair_Homo sapiens_hsa034301.49891508
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.46093266
27Allograft rejection_Homo sapiens_hsa053301.45479234
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39943350
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39089134
30Autoimmune thyroid disease_Homo sapiens_hsa053201.38040636
31Spliceosome_Homo sapiens_hsa030401.28567459
32Phototransduction_Homo sapiens_hsa047441.25928853
33Non-homologous end-joining_Homo sapiens_hsa034501.25689694
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25183182
35Peroxisome_Homo sapiens_hsa041461.22567211
36Linoleic acid metabolism_Homo sapiens_hsa005911.21730055
37RNA transport_Homo sapiens_hsa030131.21467726
38Butanoate metabolism_Homo sapiens_hsa006501.20651877
39Alzheimers disease_Homo sapiens_hsa050101.20012974
40Nucleotide excision repair_Homo sapiens_hsa034201.19854527
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.17357329
42Fanconi anemia pathway_Homo sapiens_hsa034601.16717981
43Fatty acid degradation_Homo sapiens_hsa000711.14190032
44Pyruvate metabolism_Homo sapiens_hsa006201.07689661
45Ribosome_Homo sapiens_hsa030101.07016065
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.06651563
47Base excision repair_Homo sapiens_hsa034101.02687549
48Collecting duct acid secretion_Homo sapiens_hsa049660.99725888
49Pyrimidine metabolism_Homo sapiens_hsa002400.98067637
50Nitrogen metabolism_Homo sapiens_hsa009100.97012429
51Carbon metabolism_Homo sapiens_hsa012000.94503761
52Caffeine metabolism_Homo sapiens_hsa002320.92476633
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91348676
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87206193
55Fatty acid metabolism_Homo sapiens_hsa012120.86968357
56beta-Alanine metabolism_Homo sapiens_hsa004100.86553805
57Purine metabolism_Homo sapiens_hsa002300.86081392
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85803912
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83415671
60Retinol metabolism_Homo sapiens_hsa008300.82448909
61Steroid biosynthesis_Homo sapiens_hsa001000.81868485
62Type I diabetes mellitus_Homo sapiens_hsa049400.73931411
63Biosynthesis of amino acids_Homo sapiens_hsa012300.73415408
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73357463
65Chemical carcinogenesis_Homo sapiens_hsa052040.73277881
66Selenocompound metabolism_Homo sapiens_hsa004500.71851966
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.71659071
68Metabolic pathways_Homo sapiens_hsa011000.71479390
69Ether lipid metabolism_Homo sapiens_hsa005650.70855328
70Vitamin digestion and absorption_Homo sapiens_hsa049770.69521869
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64220857
72Primary immunodeficiency_Homo sapiens_hsa053400.63908423
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62739576
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60400784
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60360020
76Cardiac muscle contraction_Homo sapiens_hsa042600.60217370
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57978188
78Fat digestion and absorption_Homo sapiens_hsa049750.57348669
79Glutathione metabolism_Homo sapiens_hsa004800.56807364
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56323240
81Hematopoietic cell lineage_Homo sapiens_hsa046400.53484688
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52109136
83Sulfur metabolism_Homo sapiens_hsa009200.50206990
84Histidine metabolism_Homo sapiens_hsa003400.49056172
85Nicotine addiction_Homo sapiens_hsa050330.47328932
86Antigen processing and presentation_Homo sapiens_hsa046120.46142850
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44692947
88Taste transduction_Homo sapiens_hsa047420.43877215
89Arginine and proline metabolism_Homo sapiens_hsa003300.43785166
90Rheumatoid arthritis_Homo sapiens_hsa053230.43542832
91Systemic lupus erythematosus_Homo sapiens_hsa053220.43349508
92Graft-versus-host disease_Homo sapiens_hsa053320.43228947
93Arachidonic acid metabolism_Homo sapiens_hsa005900.43194545
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39899560
95Tyrosine metabolism_Homo sapiens_hsa003500.39372686
96Sphingolipid metabolism_Homo sapiens_hsa006000.39201395
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37926374
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36389976
99Phenylalanine metabolism_Homo sapiens_hsa003600.36262527
100Olfactory transduction_Homo sapiens_hsa047400.26953374

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »