

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.34601486 |
| 2 | DNA deamination (GO:0045006) | 4.82065766 |
| 3 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.60775955 |
| 4 | regulation of chronic inflammatory response (GO:0002676) | 4.54747867 |
| 5 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.51278254 |
| 6 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 4.42162060 |
| 7 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 4.42162060 |
| 8 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 4.42162060 |
| 9 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 4.40686967 |
| 10 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 4.40686967 |
| 11 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.37240021 |
| 12 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.36016583 |
| 13 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 4.29077892 |
| 14 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.18286116 |
| 15 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 4.18030627 |
| 16 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 4.18030627 |
| 17 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.12415971 |
| 18 | cilium or flagellum-dependent cell motility (GO:0001539) | 4.10804097 |
| 19 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.03207369 |
| 20 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.91537219 |
| 21 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.91537219 |
| 22 | rRNA modification (GO:0000154) | 3.88556254 |
| 23 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.87467352 |
| 24 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.83760586 |
| 25 | negative regulation of ligase activity (GO:0051352) | 3.83760586 |
| 26 | rRNA methylation (GO:0031167) | 3.81653897 |
| 27 | chaperone-mediated protein transport (GO:0072321) | 3.80866839 |
| 28 | retinal cone cell development (GO:0046549) | 3.72707123 |
| 29 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.72384561 |
| 30 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.72370368 |
| 31 | maturation of 5.8S rRNA (GO:0000460) | 3.72170747 |
| 32 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.61075077 |
| 33 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.59290483 |
| 34 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.57853100 |
| 35 | ATP synthesis coupled proton transport (GO:0015986) | 3.57853100 |
| 36 | transcription from mitochondrial promoter (GO:0006390) | 3.56938376 |
| 37 | negative regulation of telomere maintenance (GO:0032205) | 3.55281591 |
| 38 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.51103505 |
| 39 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.49224242 |
| 40 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.45709985 |
| 41 | DNA damage response, detection of DNA damage (GO:0042769) | 3.43632707 |
| 42 | mitochondrial RNA metabolic process (GO:0000959) | 3.39720310 |
| 43 | protein deneddylation (GO:0000338) | 3.38410203 |
| 44 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 3.36684885 |
| 45 | neural tube formation (GO:0001841) | 3.36382608 |
| 46 | positive regulation of ligase activity (GO:0051351) | 3.28874334 |
| 47 | lactate metabolic process (GO:0006089) | 3.26719397 |
| 48 | cullin deneddylation (GO:0010388) | 3.25836539 |
| 49 | termination of RNA polymerase I transcription (GO:0006363) | 3.22236847 |
| 50 | positive regulation of cell cycle arrest (GO:0071158) | 3.21981244 |
| 51 | regulation of cellular amine metabolic process (GO:0033238) | 3.18190762 |
| 52 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.15923003 |
| 53 | glial cell proliferation (GO:0014009) | 3.15214691 |
| 54 | DNA replication checkpoint (GO:0000076) | 3.15000384 |
| 55 | organelle disassembly (GO:1903008) | 3.11823664 |
| 56 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.09776045 |
| 57 | limb bud formation (GO:0060174) | 3.09037181 |
| 58 | ubiquinone biosynthetic process (GO:0006744) | 3.03194585 |
| 59 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.02816429 |
| 60 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.02816429 |
| 61 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.01574604 |
| 62 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.95960642 |
| 63 | regulation of helicase activity (GO:0051095) | 2.95927103 |
| 64 | signal transduction in response to DNA damage (GO:0042770) | 2.93260213 |
| 65 | transcription from RNA polymerase I promoter (GO:0006360) | 2.89304998 |
| 66 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.88785409 |
| 67 | DNA double-strand break processing (GO:0000729) | 2.88778382 |
| 68 | telomere maintenance via telomerase (GO:0007004) | 2.87911783 |
| 69 | single strand break repair (GO:0000012) | 2.86444098 |
| 70 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.86360449 |
| 71 | pseudouridine synthesis (GO:0001522) | 2.85684206 |
| 72 | ubiquinone metabolic process (GO:0006743) | 2.80862373 |
| 73 | regulation of ligase activity (GO:0051340) | 2.77127265 |
| 74 | negative regulation of protein ubiquitination (GO:0031397) | 2.74745388 |
| 75 | protein neddylation (GO:0045116) | 2.74525132 |
| 76 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.73036342 |
| 77 | ribosome assembly (GO:0042255) | 2.72991929 |
| 78 | nucleobase catabolic process (GO:0046113) | 2.72914546 |
| 79 | epithelial cilium movement (GO:0003351) | 2.72907424 |
| 80 | protein complex biogenesis (GO:0070271) | 2.72692066 |
| 81 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.69153670 |
| 82 | regulation of MHC class II biosynthetic process (GO:0045346) | 2.69097288 |
| 83 | S-adenosylmethionine metabolic process (GO:0046500) | 2.68671104 |
| 84 | indolalkylamine metabolic process (GO:0006586) | 2.68624750 |
| 85 | negative regulation of cell cycle G1/S phase transition (GO:1902807) | 2.68219813 |
| 86 | negative regulation of G1/S transition of mitotic cell cycle (GO:2000134) | 2.68219813 |
| 87 | respiratory chain complex IV assembly (GO:0008535) | 2.67769275 |
| 88 | regulation of cell cycle arrest (GO:0071156) | 2.65816798 |
| 89 | cytochrome complex assembly (GO:0017004) | 2.64613517 |
| 90 | axoneme assembly (GO:0035082) | 2.64462449 |
| 91 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.63831172 |
| 92 | kidney morphogenesis (GO:0060993) | 2.62836259 |
| 93 | cilium movement (GO:0003341) | 2.62514516 |
| 94 | aldehyde catabolic process (GO:0046185) | 2.59287650 |
| 95 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 2.58690109 |
| 96 | electron transport chain (GO:0022900) | 2.58505299 |
| 97 | methionine biosynthetic process (GO:0009086) | 2.58278551 |
| 98 | kynurenine metabolic process (GO:0070189) | 2.58225389 |
| 99 | ribosome biogenesis (GO:0042254) | 2.57945110 |
| 100 | respiratory electron transport chain (GO:0022904) | 2.57780068 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.92368057 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.33315797 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.12032376 |
| 4 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 4.11923443 |
| 5 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.12522895 |
| 6 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.96198312 |
| 7 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.92190050 |
| 8 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.82550281 |
| 9 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.70790046 |
| 10 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.67499958 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.65253341 |
| 12 | VDR_22108803_ChIP-Seq_LS180_Human | 2.60540374 |
| 13 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.44150904 |
| 14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.33334934 |
| 15 | EWS_26573619_Chip-Seq_HEK293_Human | 2.32325262 |
| 16 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.17160347 |
| 17 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.12409148 |
| 18 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.12008636 |
| 19 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.11523667 |
| 20 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.06613726 |
| 21 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.03889301 |
| 22 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.90209279 |
| 23 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.90195836 |
| 24 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.89142060 |
| 25 | FUS_26573619_Chip-Seq_HEK293_Human | 1.87088165 |
| 26 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.84794042 |
| 27 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.76105312 |
| 28 | P300_19829295_ChIP-Seq_ESCs_Human | 1.66640751 |
| 29 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.63082219 |
| 30 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.59770333 |
| 31 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.56081540 |
| 32 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.55009290 |
| 33 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.53993062 |
| 34 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.51090798 |
| 35 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.50836237 |
| 36 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.48337048 |
| 37 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.45266793 |
| 38 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.45042332 |
| 39 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.44125413 |
| 40 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.42702377 |
| 41 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.42543097 |
| 42 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.41788007 |
| 43 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.40517052 |
| 44 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.40428493 |
| 45 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.40402162 |
| 46 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.40399288 |
| 47 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.39377174 |
| 48 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.35717910 |
| 49 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.31397428 |
| 50 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.27711822 |
| 51 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.27676626 |
| 52 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.27078708 |
| 53 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.26993468 |
| 54 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.26904666 |
| 55 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.24060187 |
| 56 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.22846102 |
| 57 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.22846102 |
| 58 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.22804342 |
| 59 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.20848066 |
| 60 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.19566863 |
| 61 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.15697840 |
| 62 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.15371984 |
| 63 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.15289317 |
| 64 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.15289317 |
| 65 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.12673313 |
| 66 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.12622624 |
| 67 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.12150075 |
| 68 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.11227633 |
| 69 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.08638839 |
| 70 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.07032248 |
| 71 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.06909558 |
| 72 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.06772739 |
| 73 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.06772739 |
| 74 | AR_20517297_ChIP-Seq_VCAP_Human | 1.06538767 |
| 75 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 1.05984371 |
| 76 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.03883593 |
| 77 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.02426011 |
| 78 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.02100511 |
| 79 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.01350391 |
| 80 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.00628940 |
| 81 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 0.99812748 |
| 82 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.98368834 |
| 83 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.97934049 |
| 84 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.97843968 |
| 85 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.95072015 |
| 86 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.92568770 |
| 87 | TTF2_22483619_ChIP-Seq_HELA_Human | 0.92516913 |
| 88 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.92327994 |
| 89 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.92188816 |
| 90 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.91949413 |
| 91 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.90862121 |
| 92 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 0.90607902 |
| 93 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.90200882 |
| 94 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.89073977 |
| 95 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.89041362 |
| 96 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.88367842 |
| 97 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.88346924 |
| 98 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.88159168 |
| 99 | GATA3_26560356_Chip-Seq_TH2_Human | 0.87670985 |
| 100 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.87429721 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002102_abnormal_ear_morphology | 4.43320645 |
| 2 | MP0008057_abnormal_DNA_replication | 3.35890052 |
| 3 | MP0008058_abnormal_DNA_repair | 3.31464664 |
| 4 | MP0002234_abnormal_pharynx_morphology | 3.22988011 |
| 5 | MP0001348_abnormal_lacrimal_gland | 3.22981493 |
| 6 | MP0008875_abnormal_xenobiotic_pharmacok | 2.92096626 |
| 7 | MP0002837_dystrophic_cardiac_calcinosis | 2.72757220 |
| 8 | MP0003646_muscle_fatigue | 2.67377941 |
| 9 | MP0003718_maternal_effect | 2.29865554 |
| 10 | MP0006036_abnormal_mitochondrial_physio | 2.17632505 |
| 11 | MP0008872_abnormal_physiological_respon | 2.17404317 |
| 12 | MP0003195_calcinosis | 2.01072062 |
| 13 | MP0003950_abnormal_plasma_membrane | 1.97533158 |
| 14 | MP0005551_abnormal_eye_electrophysiolog | 1.90969021 |
| 15 | MP0008995_early_reproductive_senescence | 1.84969559 |
| 16 | MP0001873_stomach_inflammation | 1.84747192 |
| 17 | MP0004145_abnormal_muscle_electrophysio | 1.82917862 |
| 18 | MP0001188_hyperpigmentation | 1.81017556 |
| 19 | MP0002751_abnormal_autonomic_nervous | 1.79749513 |
| 20 | MP0006035_abnormal_mitochondrial_morpho | 1.78802192 |
| 21 | MP0001984_abnormal_olfaction | 1.75867494 |
| 22 | MP0002653_abnormal_ependyma_morphology | 1.71471876 |
| 23 | MP0004957_abnormal_blastocyst_morpholog | 1.69160741 |
| 24 | MP0005253_abnormal_eye_physiology | 1.69007243 |
| 25 | MP0003890_abnormal_embryonic-extraembry | 1.68721857 |
| 26 | MP0001835_abnormal_antigen_presentation | 1.66548277 |
| 27 | MP0003786_premature_aging | 1.59303589 |
| 28 | MP0003787_abnormal_imprinting | 1.57479756 |
| 29 | MP0001501_abnormal_sleep_pattern | 1.56434069 |
| 30 | MP0002736_abnormal_nociception_after | 1.53676307 |
| 31 | MP0008877_abnormal_DNA_methylation | 1.51222116 |
| 32 | MP0006292_abnormal_olfactory_placode | 1.45248927 |
| 33 | MP0001529_abnormal_vocalization | 1.44993646 |
| 34 | MP0001905_abnormal_dopamine_level | 1.44268032 |
| 35 | MP0000685_abnormal_immune_system | 1.42323700 |
| 36 | MP0003011_delayed_dark_adaptation | 1.42068568 |
| 37 | MP0008789_abnormal_olfactory_epithelium | 1.41916950 |
| 38 | MP0001968_abnormal_touch/_nociception | 1.30579805 |
| 39 | MP0008775_abnormal_heart_ventricle | 1.28987433 |
| 40 | MP0002138_abnormal_hepatobiliary_system | 1.24371411 |
| 41 | MP0001764_abnormal_homeostasis | 1.22601576 |
| 42 | MP0006072_abnormal_retinal_apoptosis | 1.21586679 |
| 43 | MP0003567_abnormal_fetal_cardiomyocyte | 1.21538264 |
| 44 | MP0002277_abnormal_respiratory_mucosa | 1.21079801 |
| 45 | MP0005084_abnormal_gallbladder_morpholo | 1.19844974 |
| 46 | MP0004084_abnormal_cardiac_muscle | 1.16728270 |
| 47 | MP0009764_decreased_sensitivity_to | 1.16015756 |
| 48 | MP0009785_altered_susceptibility_to | 1.15927760 |
| 49 | MP0001293_anophthalmia | 1.15842664 |
| 50 | MP0005423_abnormal_somatic_nervous | 1.15825998 |
| 51 | MP0006082_CNS_inflammation | 1.13184612 |
| 52 | MP0003119_abnormal_digestive_system | 1.10168023 |
| 53 | MP0003111_abnormal_nucleus_morphology | 1.10034030 |
| 54 | MP0002272_abnormal_nervous_system | 1.08864890 |
| 55 | MP0010094_abnormal_chromosome_stability | 1.05878627 |
| 56 | MP0003693_abnormal_embryo_hatching | 1.03064646 |
| 57 | MP0005395_other_phenotype | 1.01061666 |
| 58 | MP0001286_abnormal_eye_development | 0.99424285 |
| 59 | MP0005410_abnormal_fertilization | 0.98028226 |
| 60 | MP0003137_abnormal_impulse_conducting | 0.96689373 |
| 61 | MP0005266_abnormal_metabolism | 0.94519473 |
| 62 | MP0003077_abnormal_cell_cycle | 0.93686038 |
| 63 | MP0005075_abnormal_melanosome_morpholog | 0.93405493 |
| 64 | MP0005085_abnormal_gallbladder_physiolo | 0.92835058 |
| 65 | MP0002254_reproductive_system_inflammat | 0.91172551 |
| 66 | MP0000427_abnormal_hair_cycle | 0.89377563 |
| 67 | MP0002282_abnormal_trachea_morphology | 0.86385443 |
| 68 | MP0005671_abnormal_response_to | 0.85940749 |
| 69 | MP0005499_abnormal_olfactory_system | 0.85273738 |
| 70 | MP0005394_taste/olfaction_phenotype | 0.85273738 |
| 71 | MP0000613_abnormal_salivary_gland | 0.85028117 |
| 72 | MP0004142_abnormal_muscle_tone | 0.84082214 |
| 73 | MP0002090_abnormal_vision | 0.83579717 |
| 74 | MP0002876_abnormal_thyroid_physiology | 0.82816809 |
| 75 | MP0002210_abnormal_sex_determination | 0.82202736 |
| 76 | MP0005195_abnormal_posterior_eye | 0.81239388 |
| 77 | MP0010386_abnormal_urinary_bladder | 0.81066226 |
| 78 | MP0000647_abnormal_sebaceous_gland | 0.79335731 |
| 79 | MP0003186_abnormal_redox_activity | 0.78395202 |
| 80 | MP0000049_abnormal_middle_ear | 0.78346531 |
| 81 | MP0001929_abnormal_gametogenesis | 0.77715730 |
| 82 | MP0004215_abnormal_myocardial_fiber | 0.77301748 |
| 83 | MP0002938_white_spotting | 0.77239227 |
| 84 | MP0002184_abnormal_innervation | 0.76492986 |
| 85 | MP0002148_abnormal_hypersensitivity_rea | 0.76297720 |
| 86 | MP0005645_abnormal_hypothalamus_physiol | 0.76004993 |
| 87 | MP0001346_abnormal_lacrimal_gland | 0.74661941 |
| 88 | MP0003938_abnormal_ear_development | 0.71628823 |
| 89 | MP0002752_abnormal_somatic_nervous | 0.71160472 |
| 90 | MP0002557_abnormal_social/conspecific_i | 0.70826631 |
| 91 | MP0009745_abnormal_behavioral_response | 0.70771604 |
| 92 | MP0004085_abnormal_heartbeat | 0.68727783 |
| 93 | MP0009046_muscle_twitch | 0.68273157 |
| 94 | MP0003121_genomic_imprinting | 0.66992927 |
| 95 | MP0010234_abnormal_vibrissa_follicle | 0.66036254 |
| 96 | MP0005636_abnormal_mineral_homeostasis | 0.65104365 |
| 97 | MP0001119_abnormal_female_reproductive | 0.64861886 |
| 98 | MP0004742_abnormal_vestibular_system | 0.64339135 |
| 99 | MP0003880_abnormal_central_pattern | 0.63675197 |
| 100 | MP0000653_abnormal_sex_gland | 0.62038477 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.28666895 |
| 2 | Abnormality of the labia minora (HP:0012880) | 3.95161583 |
| 3 | Acute encephalopathy (HP:0006846) | 3.80849149 |
| 4 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.74130782 |
| 5 | Absent/shortened dynein arms (HP:0200106) | 3.74130782 |
| 6 | Increased CSF lactate (HP:0002490) | 3.64509850 |
| 7 | Progressive macrocephaly (HP:0004481) | 3.60205512 |
| 8 | Mitochondrial inheritance (HP:0001427) | 3.57080609 |
| 9 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 3.55461015 |
| 10 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.50895767 |
| 11 | Chronic bronchitis (HP:0004469) | 3.50562317 |
| 12 | Hepatocellular necrosis (HP:0001404) | 3.33206962 |
| 13 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 3.28098538 |
| 14 | Increased hepatocellular lipid droplets (HP:0006565) | 3.18815331 |
| 15 | Hepatic necrosis (HP:0002605) | 3.14535259 |
| 16 | Optic disc pallor (HP:0000543) | 3.06060147 |
| 17 | Methylmalonic acidemia (HP:0002912) | 2.98129786 |
| 18 | Molar tooth sign on MRI (HP:0002419) | 2.93908447 |
| 19 | Abnormality of midbrain morphology (HP:0002418) | 2.93908447 |
| 20 | Methylmalonic aciduria (HP:0012120) | 2.87933154 |
| 21 | Lipid accumulation in hepatocytes (HP:0006561) | 2.87535671 |
| 22 | Constricted visual fields (HP:0001133) | 2.85854494 |
| 23 | Cerebral edema (HP:0002181) | 2.83210680 |
| 24 | Hyperglycinemia (HP:0002154) | 2.83011771 |
| 25 | Increased serum lactate (HP:0002151) | 2.80520682 |
| 26 | Pancreatic cysts (HP:0001737) | 2.75906037 |
| 27 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.69265787 |
| 28 | Colon cancer (HP:0003003) | 2.67116047 |
| 29 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.65992351 |
| 30 | Patellar aplasia (HP:0006443) | 2.64965126 |
| 31 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.53297330 |
| 32 | Retinal dysplasia (HP:0007973) | 2.47023556 |
| 33 | Lissencephaly (HP:0001339) | 2.43747078 |
| 34 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.42310893 |
| 35 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.42310893 |
| 36 | 3-Methylglutaconic aciduria (HP:0003535) | 2.39256107 |
| 37 | Respiratory failure (HP:0002878) | 2.36741890 |
| 38 | Renal Fanconi syndrome (HP:0001994) | 2.36575695 |
| 39 | Large for gestational age (HP:0001520) | 2.36019541 |
| 40 | Abnormal ciliary motility (HP:0012262) | 2.35214315 |
| 41 | Hypomagnesemia (HP:0002917) | 2.31432428 |
| 42 | Abolished electroretinogram (ERG) (HP:0000550) | 2.31192232 |
| 43 | Pendular nystagmus (HP:0012043) | 2.28361691 |
| 44 | Lactic acidosis (HP:0003128) | 2.27197206 |
| 45 | Hyperglycinuria (HP:0003108) | 2.26491304 |
| 46 | Fibular aplasia (HP:0002990) | 2.25818319 |
| 47 | Rhinitis (HP:0012384) | 2.23790202 |
| 48 | Lethargy (HP:0001254) | 2.21966302 |
| 49 | Increased corneal curvature (HP:0100692) | 2.20969346 |
| 50 | Keratoconus (HP:0000563) | 2.20969346 |
| 51 | Type II lissencephaly (HP:0007260) | 2.16642337 |
| 52 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.13040114 |
| 53 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.12782247 |
| 54 | Abnormality of glycine metabolism (HP:0010895) | 2.12782247 |
| 55 | CNS demyelination (HP:0007305) | 2.12145855 |
| 56 | Abnormality of the renal cortex (HP:0011035) | 2.11113916 |
| 57 | Inability to walk (HP:0002540) | 2.10638347 |
| 58 | Nephronophthisis (HP:0000090) | 2.10356959 |
| 59 | Pancreatic fibrosis (HP:0100732) | 2.09368922 |
| 60 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.09104868 |
| 61 | Generalized aminoaciduria (HP:0002909) | 2.08231869 |
| 62 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.07645932 |
| 63 | True hermaphroditism (HP:0010459) | 2.05810915 |
| 64 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.05194264 |
| 65 | Degeneration of anterior horn cells (HP:0002398) | 2.05075771 |
| 66 | Abnormality of the anterior horn cell (HP:0006802) | 2.05075771 |
| 67 | Cerebral hypomyelination (HP:0006808) | 2.04450646 |
| 68 | Abnormal hair whorl (HP:0010721) | 2.03264999 |
| 69 | Exertional dyspnea (HP:0002875) | 2.03060911 |
| 70 | Cellular immunodeficiency (HP:0005374) | 1.99739492 |
| 71 | Progressive inability to walk (HP:0002505) | 1.99409361 |
| 72 | Abnormality of serum amino acid levels (HP:0003112) | 1.98229965 |
| 73 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.94051420 |
| 74 | Homocystinuria (HP:0002156) | 1.93139420 |
| 75 | Abnormality of homocysteine metabolism (HP:0010919) | 1.93139420 |
| 76 | Polyuria (HP:0000103) | 1.91747180 |
| 77 | Exercise intolerance (HP:0003546) | 1.91643242 |
| 78 | Bronchitis (HP:0012387) | 1.91214956 |
| 79 | Abnormality of vitamin B metabolism (HP:0004340) | 1.89509527 |
| 80 | Hypochromic microcytic anemia (HP:0004840) | 1.88003619 |
| 81 | Chronic hepatic failure (HP:0100626) | 1.84247046 |
| 82 | Leukodystrophy (HP:0002415) | 1.80912805 |
| 83 | Attenuation of retinal blood vessels (HP:0007843) | 1.79277718 |
| 84 | Neoplasm of the adrenal gland (HP:0100631) | 1.79093483 |
| 85 | Congenital stationary night blindness (HP:0007642) | 1.78721410 |
| 86 | Blindness (HP:0000618) | 1.77588698 |
| 87 | Abnormality of the pons (HP:0007361) | 1.76618372 |
| 88 | Renal cortical cysts (HP:0000803) | 1.74655459 |
| 89 | Abnormality of the renal medulla (HP:0100957) | 1.74078301 |
| 90 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.70599412 |
| 91 | Adactyly (HP:0009776) | 1.70223784 |
| 92 | Increased intramyocellular lipid droplets (HP:0012240) | 1.70219463 |
| 93 | Type 2 muscle fiber atrophy (HP:0003554) | 1.69271640 |
| 94 | Delayed CNS myelination (HP:0002188) | 1.68689859 |
| 95 | Pachygyria (HP:0001302) | 1.66970089 |
| 96 | Aplasia/Hypoplasia of the ulna (HP:0006495) | 1.66181598 |
| 97 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.65621674 |
| 98 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.65621674 |
| 99 | X-linked dominant inheritance (HP:0001423) | 1.64491180 |
| 100 | Hyperalaninemia (HP:0003348) | 1.64059322 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRIM28 | 3.89419775 |
| 2 | SRPK1 | 3.46799978 |
| 3 | TSSK6 | 3.42700820 |
| 4 | EIF2AK1 | 2.87513643 |
| 5 | VRK2 | 2.83941242 |
| 6 | NUAK1 | 2.50272187 |
| 7 | STK16 | 2.47936750 |
| 8 | TAF1 | 2.47372659 |
| 9 | CASK | 2.44662522 |
| 10 | PBK | 2.43925566 |
| 11 | EIF2AK3 | 2.28632017 |
| 12 | MST4 | 2.21481649 |
| 13 | ZAK | 2.18390775 |
| 14 | BCR | 2.09372671 |
| 15 | MKNK2 | 2.08989140 |
| 16 | TLK1 | 2.03953144 |
| 17 | BUB1 | 1.95809354 |
| 18 | FRK | 1.92655723 |
| 19 | BMPR1B | 1.92168076 |
| 20 | CSNK1A1L | 1.85264909 |
| 21 | ADRBK2 | 1.85224727 |
| 22 | CSNK1G3 | 1.82879374 |
| 23 | WNK3 | 1.81776422 |
| 24 | CSNK1G1 | 1.65143798 |
| 25 | CSNK1G2 | 1.61064523 |
| 26 | MKNK1 | 1.60254633 |
| 27 | GRK1 | 1.60069335 |
| 28 | MAP3K9 | 1.57559031 |
| 29 | PLK3 | 1.55154492 |
| 30 | VRK1 | 1.53221687 |
| 31 | OXSR1 | 1.44284531 |
| 32 | MARK1 | 1.38645114 |
| 33 | PAK3 | 1.31394306 |
| 34 | DYRK2 | 1.28850988 |
| 35 | ERBB3 | 1.25124352 |
| 36 | BCKDK | 1.24659052 |
| 37 | SIK3 | 1.16464129 |
| 38 | NME1 | 1.15272575 |
| 39 | PINK1 | 1.12981883 |
| 40 | STK39 | 1.11073312 |
| 41 | DAPK1 | 1.09663641 |
| 42 | WNK4 | 1.04761448 |
| 43 | MAP3K4 | 1.00989580 |
| 44 | DYRK3 | 0.97150716 |
| 45 | EPHA3 | 0.94827997 |
| 46 | ACVR1B | 0.93729630 |
| 47 | PNCK | 0.90004940 |
| 48 | CDC7 | 0.89489117 |
| 49 | WEE1 | 0.87027205 |
| 50 | NEK1 | 0.84403662 |
| 51 | PDK2 | 0.80796877 |
| 52 | EIF2AK2 | 0.78153151 |
| 53 | INSRR | 0.76216694 |
| 54 | RAF1 | 0.75166263 |
| 55 | MINK1 | 0.72835562 |
| 56 | MAP2K7 | 0.72834740 |
| 57 | STK4 | 0.70258371 |
| 58 | PLK1 | 0.70006401 |
| 59 | TAOK3 | 0.66153304 |
| 60 | ALK | 0.57489418 |
| 61 | ATR | 0.57268083 |
| 62 | TIE1 | 0.56756073 |
| 63 | PRKCG | 0.53779451 |
| 64 | KIT | 0.52908688 |
| 65 | DAPK2 | 0.52765155 |
| 66 | MAPKAPK3 | 0.51602375 |
| 67 | NLK | 0.50190146 |
| 68 | TGFBR1 | 0.49592052 |
| 69 | PASK | 0.49015004 |
| 70 | PLK4 | 0.47037603 |
| 71 | CSNK2A1 | 0.42271852 |
| 72 | TNIK | 0.42078875 |
| 73 | FLT3 | 0.41979678 |
| 74 | GRK5 | 0.40895072 |
| 75 | MET | 0.40592122 |
| 76 | AURKA | 0.40174387 |
| 77 | TTK | 0.38918665 |
| 78 | MYLK | 0.37605659 |
| 79 | PAK1 | 0.36237698 |
| 80 | PAK6 | 0.33484668 |
| 81 | MAPK13 | 0.32668402 |
| 82 | PIK3CG | 0.32326284 |
| 83 | OBSCN | 0.31976383 |
| 84 | RPS6KA5 | 0.30788005 |
| 85 | MAP4K2 | 0.29817233 |
| 86 | CSNK1E | 0.29564100 |
| 87 | AURKB | 0.28461714 |
| 88 | CSNK1D | 0.27246086 |
| 89 | AKT3 | 0.26931749 |
| 90 | CSNK1A1 | 0.26855793 |
| 91 | MARK3 | 0.25217071 |
| 92 | CCNB1 | 0.25111231 |
| 93 | TXK | 0.24394853 |
| 94 | PRKCI | 0.23694706 |
| 95 | CSNK2A2 | 0.23219477 |
| 96 | STK38L | 0.22918116 |
| 97 | ADRBK1 | 0.22851582 |
| 98 | PLK2 | 0.22362427 |
| 99 | IKBKB | 0.21740823 |
| 100 | FGR | 0.20814977 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.47568271 |
| 2 | Protein export_Homo sapiens_hsa03060 | 2.75034860 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.65163962 |
| 4 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.55136518 |
| 5 | Asthma_Homo sapiens_hsa05310 | 2.38069321 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.23837850 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 2.19380554 |
| 8 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.12450585 |
| 9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.12125214 |
| 10 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.08881137 |
| 11 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.04664302 |
| 12 | Basal transcription factors_Homo sapiens_hsa03022 | 2.03816568 |
| 13 | Homologous recombination_Homo sapiens_hsa03440 | 1.89591676 |
| 14 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.79547320 |
| 15 | Huntingtons disease_Homo sapiens_hsa05016 | 1.77881854 |
| 16 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.72921802 |
| 17 | RNA degradation_Homo sapiens_hsa03018 | 1.72469623 |
| 18 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.72180794 |
| 19 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.71391672 |
| 20 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.66592683 |
| 21 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.64437524 |
| 22 | DNA replication_Homo sapiens_hsa03030 | 1.60192128 |
| 23 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.54616506 |
| 24 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.52580614 |
| 25 | Mismatch repair_Homo sapiens_hsa03430 | 1.49891508 |
| 26 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.46093266 |
| 27 | Allograft rejection_Homo sapiens_hsa05330 | 1.45479234 |
| 28 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.39943350 |
| 29 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.39089134 |
| 30 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.38040636 |
| 31 | Spliceosome_Homo sapiens_hsa03040 | 1.28567459 |
| 32 | Phototransduction_Homo sapiens_hsa04744 | 1.25928853 |
| 33 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.25689694 |
| 34 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.25183182 |
| 35 | Peroxisome_Homo sapiens_hsa04146 | 1.22567211 |
| 36 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.21730055 |
| 37 | RNA transport_Homo sapiens_hsa03013 | 1.21467726 |
| 38 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.20651877 |
| 39 | Alzheimers disease_Homo sapiens_hsa05010 | 1.20012974 |
| 40 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.19854527 |
| 41 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.17357329 |
| 42 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.16717981 |
| 43 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.14190032 |
| 44 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.07689661 |
| 45 | Ribosome_Homo sapiens_hsa03010 | 1.07016065 |
| 46 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.06651563 |
| 47 | Base excision repair_Homo sapiens_hsa03410 | 1.02687549 |
| 48 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.99725888 |
| 49 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.98067637 |
| 50 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.97012429 |
| 51 | Carbon metabolism_Homo sapiens_hsa01200 | 0.94503761 |
| 52 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.92476633 |
| 53 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.91348676 |
| 54 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.87206193 |
| 55 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.86968357 |
| 56 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.86553805 |
| 57 | Purine metabolism_Homo sapiens_hsa00230 | 0.86081392 |
| 58 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.85803912 |
| 59 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.83415671 |
| 60 | Retinol metabolism_Homo sapiens_hsa00830 | 0.82448909 |
| 61 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.81868485 |
| 62 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.73931411 |
| 63 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.73415408 |
| 64 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.73357463 |
| 65 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.73277881 |
| 66 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.71851966 |
| 67 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.71659071 |
| 68 | Metabolic pathways_Homo sapiens_hsa01100 | 0.71479390 |
| 69 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.70855328 |
| 70 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.69521869 |
| 71 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.64220857 |
| 72 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.63908423 |
| 73 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.62739576 |
| 74 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.60400784 |
| 75 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.60360020 |
| 76 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.60217370 |
| 77 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.57978188 |
| 78 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.57348669 |
| 79 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.56807364 |
| 80 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.56323240 |
| 81 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.53484688 |
| 82 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.52109136 |
| 83 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.50206990 |
| 84 | Histidine metabolism_Homo sapiens_hsa00340 | 0.49056172 |
| 85 | Nicotine addiction_Homo sapiens_hsa05033 | 0.47328932 |
| 86 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.46142850 |
| 87 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.44692947 |
| 88 | Taste transduction_Homo sapiens_hsa04742 | 0.43877215 |
| 89 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.43785166 |
| 90 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.43542832 |
| 91 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.43349508 |
| 92 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.43228947 |
| 93 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.43194545 |
| 94 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.39899560 |
| 95 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.39372686 |
| 96 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.39201395 |
| 97 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.37926374 |
| 98 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.36389976 |
| 99 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.36262527 |
| 100 | Olfactory transduction_Homo sapiens_hsa04740 | 0.26953374 |

