PSMA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.66526099
2proteasome assembly (GO:0043248)5.42936027
3ATP synthesis coupled proton transport (GO:0015986)5.26596172
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.26596172
5cullin deneddylation (GO:0010388)4.94381949
6protein deneddylation (GO:0000338)4.68097998
7ribosomal small subunit assembly (GO:0000028)4.61044625
8* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.48874655
9termination of RNA polymerase III transcription (GO:0006386)4.42651720
10transcription elongation from RNA polymerase III promoter (GO:0006385)4.42651720
11chaperone-mediated protein transport (GO:0072321)4.40496722
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.38456567
13NADH dehydrogenase complex assembly (GO:0010257)4.38456567
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.38456567
15protein neddylation (GO:0045116)4.37726814
16protein complex biogenesis (GO:0070271)4.28455951
17* regulation of cellular amino acid metabolic process (GO:0006521)4.27280424
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.18378295
19* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.14276820
20ribosomal small subunit biogenesis (GO:0042274)4.09605408
21* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.08461373
22* negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.07733326
23* negative regulation of ligase activity (GO:0051352)4.07733326
24* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.05727054
25ribosome assembly (GO:0042255)4.04773031
26* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.03080871
27DNA deamination (GO:0045006)4.02800546
287-methylguanosine mRNA capping (GO:0006370)4.02125996
29* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.00518741
30* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.00518741
31RNA capping (GO:0036260)3.99941231
327-methylguanosine RNA capping (GO:0009452)3.99941231
33* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.98591505
34* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.98591505
35* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.98591505
36mitochondrial respiratory chain complex assembly (GO:0033108)3.96356172
37DNA replication checkpoint (GO:0000076)3.90638386
38respiratory electron transport chain (GO:0022904)3.89203239
39DNA double-strand break processing (GO:0000729)3.87129029
40* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.85140346
41* signal transduction involved in DNA integrity checkpoint (GO:0072401)3.82063079
42* signal transduction involved in DNA damage checkpoint (GO:0072422)3.82063079
43maturation of SSU-rRNA (GO:0030490)3.81261090
44* signal transduction involved in cell cycle checkpoint (GO:0072395)3.80869479
45electron transport chain (GO:0022900)3.78772947
46histone exchange (GO:0043486)3.77795933
47* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.77211116
48mitotic metaphase plate congression (GO:0007080)3.77046626
49establishment of protein localization to mitochondrial membrane (GO:0090151)3.75741893
50respiratory chain complex IV assembly (GO:0008535)3.68097723
51cotranslational protein targeting to membrane (GO:0006613)3.66347171
52SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.66306658
53deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.65720695
54GTP biosynthetic process (GO:0006183)3.65593726
55guanosine-containing compound biosynthetic process (GO:1901070)3.63956508
56establishment of integrated proviral latency (GO:0075713)3.63045258
57DNA strand elongation involved in DNA replication (GO:0006271)3.62353527
58protein targeting to ER (GO:0045047)3.57924368
59L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.57791225
60viral mRNA export from host cell nucleus (GO:0046784)3.57158058
61viral transcription (GO:0019083)3.56442622
62ribosomal large subunit biogenesis (GO:0042273)3.55910637
63deoxyribose phosphate biosynthetic process (GO:0046385)3.53543799
642-deoxyribonucleotide biosynthetic process (GO:0009265)3.53543799
65* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.52919943
66translational termination (GO:0006415)3.52006907
67IMP biosynthetic process (GO:0006188)3.51987523
68regulation of mitochondrial translation (GO:0070129)3.51251878
69regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.49985235
70regulation of mitotic spindle checkpoint (GO:1903504)3.49985235
71protein localization to endoplasmic reticulum (GO:0070972)3.48890147
72translation (GO:0006412)3.48527042
73DNA replication-independent nucleosome organization (GO:0034724)3.46780352
74DNA replication-independent nucleosome assembly (GO:0006336)3.46780352
75DNA strand elongation (GO:0022616)3.45495431
76* positive regulation of ligase activity (GO:0051351)3.44072860
77histone mRNA metabolic process (GO:0008334)3.41286523
78metaphase plate congression (GO:0051310)3.40556028
79protein targeting to mitochondrion (GO:0006626)3.38998411
80* regulation of ligase activity (GO:0051340)3.38927131
81DNA catabolic process, exonucleolytic (GO:0000738)3.38766344
82CENP-A containing nucleosome assembly (GO:0034080)3.37926752
83DNA damage response, detection of DNA damage (GO:0042769)3.36210091
84establishment of protein localization to endoplasmic reticulum (GO:0072599)3.36023238
85tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.34791834
86RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.34791834
87spliceosomal snRNP assembly (GO:0000387)3.34250498
88cytochrome complex assembly (GO:0017004)3.33978289
89deoxyribonucleotide biosynthetic process (GO:0009263)3.33765786
90telomere maintenance via semi-conservative replication (GO:0032201)3.33261398
91pseudouridine synthesis (GO:0001522)3.31360952
92establishment of protein localization to mitochondrion (GO:0072655)3.30981552
93rRNA modification (GO:0000154)3.30356788
94cellular component biogenesis (GO:0044085)3.28155920
95regulation of helicase activity (GO:0051095)3.28079640
96nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.28052578
97transcription elongation from RNA polymerase I promoter (GO:0006362)3.26646190
98establishment of viral latency (GO:0019043)3.26200842
99purine nucleobase biosynthetic process (GO:0009113)3.25794394
100oxidative phosphorylation (GO:0006119)3.25217435
101ribonucleoprotein complex biogenesis (GO:0022613)3.24641453
102DNA ligation (GO:0006266)3.24301154
103* regulation of cellular amine metabolic process (GO:0033238)3.22283475
104transcription-coupled nucleotide-excision repair (GO:0006283)3.21914017
105* negative regulation of protein ubiquitination (GO:0031397)3.21409050
106spindle checkpoint (GO:0031577)3.20695825
107kinetochore organization (GO:0051383)3.20677279
108negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.20002945
109negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.20002945
110negative regulation of mitotic sister chromatid segregation (GO:0033048)3.20002945
111negative regulation of mitotic sister chromatid separation (GO:2000816)3.20002945
112negative regulation of sister chromatid segregation (GO:0033046)3.20002945
113mitotic spindle checkpoint (GO:0071174)3.19000031
114rRNA methylation (GO:0031167)3.17355073
115chromatin remodeling at centromere (GO:0031055)3.15741610
116protein localization to kinetochore (GO:0034501)3.15325039
117exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15015830
118kinetochore assembly (GO:0051382)3.14834214
119* G1/S transition of mitotic cell cycle (GO:0000082)3.13961634
120* cell cycle G1/S phase transition (GO:0044843)3.13961634
121formation of translation preinitiation complex (GO:0001731)3.13526957
122nucleobase biosynthetic process (GO:0046112)3.13467815
123negative regulation of chromosome segregation (GO:0051985)3.13172575
124* antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.12868349
125spliceosomal complex assembly (GO:0000245)3.12710897
126mitotic recombination (GO:0006312)3.12661487
127* DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.12535130
128UTP biosynthetic process (GO:0006228)3.12412941
129deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.11783440
130termination of RNA polymerase I transcription (GO:0006363)3.10736238
131translational elongation (GO:0006414)3.10487241
132telomere maintenance via recombination (GO:0000722)3.08214007
133* regulation of ubiquitin-protein transferase activity (GO:0051438)3.06436698
134peptidyl-histidine modification (GO:0018202)3.05739345
135protein localization to mitochondrion (GO:0070585)3.05461077
136replication fork processing (GO:0031297)3.03836046
137IMP metabolic process (GO:0046040)3.03571962
138negative regulation of DNA-dependent DNA replication (GO:2000104)3.03552069
139* positive regulation of cell cycle arrest (GO:0071158)3.01757755
140maturation of 5.8S rRNA (GO:0000460)3.01109820
141DNA replication-dependent nucleosome assembly (GO:0006335)3.00337030

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.03131707
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.64881281
3* EST1_17652178_ChIP-ChIP_JURKAT_Human4.32328549
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.00880968
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.91164031
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.69445661
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.67864923
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.52380786
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.50648200
10E2F7_22180533_ChIP-Seq_HELA_Human3.49130566
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.35473433
12* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.27294871
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.05110621
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.01804433
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.98703831
16* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.98018251
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.90135544
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84391956
19VDR_23849224_ChIP-Seq_CD4+_Human2.73197617
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63215899
21ELK1_19687146_ChIP-ChIP_HELA_Human2.59246686
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.57276619
23DCP1A_22483619_ChIP-Seq_HELA_Human2.44052266
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.40018945
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34728180
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.33850007
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.32883768
28* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26940632
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.26708640
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.24432399
31FOXP3_21729870_ChIP-Seq_TREG_Human2.17378607
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11486407
33XRN2_22483619_ChIP-Seq_HELA_Human2.05761155
34YY1_21170310_ChIP-Seq_MESCs_Mouse2.02373028
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98267575
36TTF2_22483619_ChIP-Seq_HELA_Human1.93795080
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.92933869
38GABP_19822575_ChIP-Seq_HepG2_Human1.92293201
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86996576
40* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.82375741
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82252908
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77496032
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.74582449
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74509256
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67100322
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61398839
47* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59573738
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58836478
49ELK1_22589737_ChIP-Seq_MCF10A_Human1.54626027
50* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48719421
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47599362
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45795363
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42712711
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40687297
55ZNF274_21170338_ChIP-Seq_K562_Hela1.38570406
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37059731
57MYC_18940864_ChIP-ChIP_HL60_Human1.37031025
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35605738
59IRF1_19129219_ChIP-ChIP_H3396_Human1.34926041
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25517245
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25200663
62* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23690181
63* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18874905
64FUS_26573619_Chip-Seq_HEK293_Human1.17877772
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.15886633
66EWS_26573619_Chip-Seq_HEK293_Human1.07820916
67CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05982121
68VDR_22108803_ChIP-Seq_LS180_Human1.05375794
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03806056
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01749585
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97630532
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96982707
73AR_21909140_ChIP-Seq_LNCAP_Human0.96532588
74E2F1_21310950_ChIP-Seq_MCF-7_Human0.96276662
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95633078
76SOX2_16153702_ChIP-ChIP_HESCs_Human0.94064169
77* SOX17_20123909_ChIP-Seq_XEN_Mouse0.93904300
78ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92455606
79PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90448772
80FLI1_27457419_Chip-Seq_LIVER_Mouse0.90313629
81POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90295591
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89726688
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.88982014
84TAF15_26573619_Chip-Seq_HEK293_Human0.88763257
85* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87448130
86IGF1R_20145208_ChIP-Seq_DFB_Human0.86997055
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86787262
88* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85336065
89BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84702242
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83725566
91KDM5A_27292631_Chip-Seq_BREAST_Human0.83129117
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82854720
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82315442
94NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82108765
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81044167
96ELF5_23300383_ChIP-Seq_T47D_Human0.80418532
97* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79805739
98P300_19829295_ChIP-Seq_ESCs_Human0.79627697
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78636950
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78132044
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77157933
102* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.76267536
103CIITA_25753668_ChIP-Seq_RAJI_Human0.75227244
104* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.73223080
105SOX2_18555785_ChIP-Seq_MESCs_Mouse0.73035790
106TFEB_21752829_ChIP-Seq_HELA_Human0.72665359
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.72287096
108* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.71852062
109FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71529658
110NANOG_16153702_ChIP-ChIP_HESCs_Human0.70902976
111TP53_22573176_ChIP-Seq_HFKS_Human0.70651248
112TP63_19390658_ChIP-ChIP_HaCaT_Human0.69873992
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.68746852
114NFE2_27457419_Chip-Seq_LIVER_Mouse0.66727223
115HTT_18923047_ChIP-ChIP_STHdh_Human0.66219428
116PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.66041507
117SPI1_23547873_ChIP-Seq_NB4_Human0.65604849
118* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.64692042
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.64231021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.59789924
2MP0001529_abnormal_vocalization3.17227064
3MP0003693_abnormal_embryo_hatching3.07015948
4MP0004957_abnormal_blastocyst_morpholog2.84121963
5MP0008058_abnormal_DNA_repair2.81004617
6MP0003880_abnormal_central_pattern2.76959227
7MP0001188_hyperpigmentation2.69551042
8MP0010094_abnormal_chromosome_stability2.53967699
9MP0008057_abnormal_DNA_replication2.52087700
10MP0006292_abnormal_olfactory_placode2.43745862
11MP0001905_abnormal_dopamine_level2.41927692
12MP0008932_abnormal_embryonic_tissue2.29739203
13MP0003186_abnormal_redox_activity2.14500993
14MP0008007_abnormal_cellular_replicative2.11171795
15MP0006276_abnormal_autonomic_nervous2.07279590
16MP0003890_abnormal_embryonic-extraembry2.07117615
17MP0001986_abnormal_taste_sensitivity2.07106938
18MP0000372_irregular_coat_pigmentation2.06143991
19MP0003786_premature_aging2.03440722
20MP0002163_abnormal_gland_morphology1.99435474
21MP0003136_yellow_coat_color1.98654305
22MP0003077_abnormal_cell_cycle1.96828970
23MP0003718_maternal_effect1.93572760
24MP0000566_synostosis1.85537913
25MP0009697_abnormal_copulation1.84857510
26MP0002638_abnormal_pupillary_reflex1.83856527
27MP0002254_reproductive_system_inflammat1.82473683
28MP0006036_abnormal_mitochondrial_physio1.81990722
29MP0002938_white_spotting1.81095006
30MP0006035_abnormal_mitochondrial_morpho1.79904198
31MP0001293_anophthalmia1.76592596
32MP0004147_increased_porphyrin_level1.70794857
33MP0002102_abnormal_ear_morphology1.68888328
34MP0002132_abnormal_respiratory_system1.64649811
35MP0003806_abnormal_nucleotide_metabolis1.61978791
36MP0002876_abnormal_thyroid_physiology1.60895981
37MP0003111_abnormal_nucleus_morphology1.60444585
38MP0008789_abnormal_olfactory_epithelium1.57049165
39MP0008877_abnormal_DNA_methylation1.56794207
40MP0003123_paternal_imprinting1.55243874
41MP0003724_increased_susceptibility_to1.52187080
42MP0003195_calcinosis1.46475500
43MP0005075_abnormal_melanosome_morpholog1.45961721
44MP0002751_abnormal_autonomic_nervous1.45408931
45MP0005171_absent_coat_pigmentation1.43313700
46MP0000015_abnormal_ear_pigmentation1.41986025
47MP0002160_abnormal_reproductive_system1.41434272
48MP0001730_embryonic_growth_arrest1.39310236
49MP0005379_endocrine/exocrine_gland_phen1.37099049
50MP0003567_abnormal_fetal_cardiomyocyte1.36428910
51MP0002736_abnormal_nociception_after1.30366532
52MP0002095_abnormal_skin_pigmentation1.26910552
53MP0001764_abnormal_homeostasis1.25644585
54MP0001697_abnormal_embryo_size1.23184075
55MP0008995_early_reproductive_senescence1.22120686
56MP0003941_abnormal_skin_development1.20519911
57MP0003315_abnormal_perineum_morphology1.20308771
58MP0002148_abnormal_hypersensitivity_rea1.19559761
59MP0004142_abnormal_muscle_tone1.18491896
60MP0002277_abnormal_respiratory_mucosa1.16631278
61MP0002837_dystrophic_cardiac_calcinosis1.15847132
62MP0010386_abnormal_urinary_bladder1.15507082
63MP0001542_abnormal_bone_strength1.15362591
64MP0009785_altered_susceptibility_to1.14102923
65MP0010307_abnormal_tumor_latency1.11504471
66MP0002735_abnormal_chemical_nociception1.11013272
67MP0003937_abnormal_limbs/digits/tail_de1.10930088
68MP0003121_genomic_imprinting1.10014184
69MP0002090_abnormal_vision1.08868131
70MP0005408_hypopigmentation1.08595834
71MP0001672_abnormal_embryogenesis/_devel1.07491256
72MP0005380_embryogenesis_phenotype1.07491256
73MP0004215_abnormal_myocardial_fiber1.07413619
74MP0000647_abnormal_sebaceous_gland1.05792007
75MP0005084_abnormal_gallbladder_morpholo1.05465731
76MP0001929_abnormal_gametogenesis1.04851114
77MP0003122_maternal_imprinting1.03543119
78MP0004381_abnormal_hair_follicle1.03272571
79MP0005389_reproductive_system_phenotype1.02134539
80MP0005409_darkened_coat_color1.01724973
81MP0000049_abnormal_middle_ear0.99683732
82MP0009333_abnormal_splenocyte_physiolog0.97558884
83MP0001968_abnormal_touch/_nociception0.97518667
84MP0005253_abnormal_eye_physiology0.97365983
85MP0003950_abnormal_plasma_membrane0.96536785
86MP0010030_abnormal_orbit_morphology0.95988125
87MP0006054_spinal_hemorrhage0.95766489
88MP0008875_abnormal_xenobiotic_pharmacok0.95223467
89MP0005395_other_phenotype0.94400826
90MP0002085_abnormal_embryonic_tissue0.93803990
91MP0002080_prenatal_lethality0.92685868
92MP0002084_abnormal_developmental_patter0.91158710
93MP0003011_delayed_dark_adaptation0.91020621
94MP0000653_abnormal_sex_gland0.90182918
95MP0005394_taste/olfaction_phenotype0.89532266
96MP0005499_abnormal_olfactory_system0.89532266
97MP0001145_abnormal_male_reproductive0.89182430
98MP0008872_abnormal_physiological_respon0.88225158
99MP0001119_abnormal_female_reproductive0.86915284
100MP0009672_abnormal_birth_weight0.85519286
101MP0000681_abnormal_thyroid_gland0.84638485
102MP0002233_abnormal_nose_morphology0.84061122
103MP0001984_abnormal_olfaction0.83579343
104MP0003119_abnormal_digestive_system0.83051953
105MP0000631_abnormal_neuroendocrine_gland0.82941858
106MP0010352_gastrointestinal_tract_polyps0.82058228
107MP0008260_abnormal_autophagy0.81647340
108MP0001835_abnormal_antigen_presentation0.80878339
109MP0002088_abnormal_embryonic_growth/wei0.79840209
110MP0003984_embryonic_growth_retardation0.79672511
111MP0004782_abnormal_surfactant_physiolog0.79534367
112MP0002019_abnormal_tumor_incidence0.77802225
113MP0001485_abnormal_pinna_reflex0.76883199
114MP0000026_abnormal_inner_ear0.76053714
115MP0000358_abnormal_cell_content/0.75036807
116MP0002234_abnormal_pharynx_morphology0.74351527
117MP0002210_abnormal_sex_determination0.74286038
118MP0001919_abnormal_reproductive_system0.73927406
119MP0001286_abnormal_eye_development0.73908258
120MP0005671_abnormal_response_to0.72607212
121MP0001881_abnormal_mammary_gland0.72379148
122MP0001853_heart_inflammation0.72311236
123MP0003221_abnormal_cardiomyocyte_apopto0.70850560
124MP0004133_heterotaxia0.70656748
125MP0003938_abnormal_ear_development0.69857646
126MP0003787_abnormal_imprinting0.69597001
127MP0005332_abnormal_amino_acid0.69046396
128MP0005646_abnormal_pituitary_gland0.68750051
129MP0005645_abnormal_hypothalamus_physiol0.67341166
130MP0005174_abnormal_tail_pigmentation0.67254343
131MP0001727_abnormal_embryo_implantation0.67066285
132MP0002111_abnormal_tail_morphology0.66662499
133MP0006072_abnormal_retinal_apoptosis0.66526682
134MP0005367_renal/urinary_system_phenotyp0.65220505
135MP0000516_abnormal_urinary_system0.65220505
136MP0000313_abnormal_cell_death0.64679637
137MP0008873_increased_physiological_sensi0.64404679
138MP0002272_abnormal_nervous_system0.63179744
139MP0002734_abnormal_mechanical_nocicepti0.63173995
140MP0000490_abnormal_crypts_of0.63065290
141MP0000350_abnormal_cell_proliferation0.62534370
142MP0003656_abnormal_erythrocyte_physiolo0.60686628
143MP0005551_abnormal_eye_electrophysiolog0.60014272
144MP0001186_pigmentation_phenotype0.59574964
145MP0005423_abnormal_somatic_nervous0.57849419
146MP0001963_abnormal_hearing_physiology0.56771783
147MP0004924_abnormal_behavior0.55323810

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.60512988
2Abnormal mitochondria in muscle tissue (HP:0008316)5.06945323
3Mitochondrial inheritance (HP:0001427)5.04010765
4Progressive macrocephaly (HP:0004481)4.56929596
5Increased CSF lactate (HP:0002490)4.45947224
6Hepatocellular necrosis (HP:0001404)4.41802624
7Acute encephalopathy (HP:0006846)4.36015287
83-Methylglutaconic aciduria (HP:0003535)4.16396656
9Increased hepatocellular lipid droplets (HP:0006565)4.05199231
10Hepatic necrosis (HP:0002605)3.81594757
11Increased serum pyruvate (HP:0003542)3.70298538
12Abnormality of glycolysis (HP:0004366)3.70298538
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.64120651
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.64120651
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.58334626
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.56220533
17Lipid accumulation in hepatocytes (HP:0006561)3.48442828
18Increased serum lactate (HP:0002151)3.44304001
19Abnormality of cells of the erythroid lineage (HP:0012130)3.42948351
20Renal Fanconi syndrome (HP:0001994)3.41955779
21Abnormal number of erythroid precursors (HP:0012131)3.35448544
22Exercise intolerance (HP:0003546)3.24415618
23Type I transferrin isoform profile (HP:0003642)3.18786742
24Abnormality of the labia minora (HP:0012880)3.11354857
25Colon cancer (HP:0003003)3.04785385
26Birth length less than 3rd percentile (HP:0003561)3.00479116
27Lactic acidosis (HP:0003128)2.97179255
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93491705
29Abnormality of methionine metabolism (HP:0010901)2.93471924
30Meckel diverticulum (HP:0002245)2.90866338
31Reticulocytopenia (HP:0001896)2.88241363
32Respiratory failure (HP:0002878)2.87548750
33Optic disc pallor (HP:0000543)2.87340699
34Methylmalonic acidemia (HP:0002912)2.85099823
35Chromsome breakage (HP:0040012)2.83586285
36Increased intramyocellular lipid droplets (HP:0012240)2.83105959
37Exertional dyspnea (HP:0002875)2.82639401
38Abnormality of chromosome stability (HP:0003220)2.81003459
39Cerebral edema (HP:0002181)2.79212402
40Abnormality of the ileum (HP:0001549)2.76375165
41Hypothermia (HP:0002045)2.67384527
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.65693003
43Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.64257428
44Leukodystrophy (HP:0002415)2.60929909
45Aplastic anemia (HP:0001915)2.60832374
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.60224160
47Abnormality of serum amino acid levels (HP:0003112)2.56893050
48Respiratory difficulties (HP:0002880)2.56889317
49Cerebral hypomyelination (HP:0006808)2.52935731
50Irregular epiphyses (HP:0010582)2.52012445
51Methylmalonic aciduria (HP:0012120)2.47434446
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45057522
53Abnormality of alanine metabolism (HP:0010916)2.45057522
54Hyperalaninemia (HP:0003348)2.45057522
55Abnormality of the heme biosynthetic pathway (HP:0010472)2.44063594
56Macrocytic anemia (HP:0001972)2.41079758
57Microvesicular hepatic steatosis (HP:0001414)2.39660125
58Hyperglycinemia (HP:0002154)2.39245504
59Parakeratosis (HP:0001036)2.35922967
60Aplasia/Hypoplasia of the sacrum (HP:0008517)2.33095951
61Multiple enchondromatosis (HP:0005701)2.32421283
62Breast hypoplasia (HP:0003187)2.30316618
63Lethargy (HP:0001254)2.29823277
64Pallor (HP:0000980)2.27347317
65Medial flaring of the eyebrow (HP:0010747)2.26061897
66Type 2 muscle fiber atrophy (HP:0003554)2.23334021
67Degeneration of anterior horn cells (HP:0002398)2.22586179
68Abnormality of the anterior horn cell (HP:0006802)2.22586179
69Reduced antithrombin III activity (HP:0001976)2.22533937
70Pancreatic fibrosis (HP:0100732)2.22229912
71Megaloblastic anemia (HP:0001889)2.21970750
72Oral leukoplakia (HP:0002745)2.21964980
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21430798
74Abnormal protein N-linked glycosylation (HP:0012347)2.21430798
75Abnormal protein glycosylation (HP:0012346)2.21430798
76Abnormal glycosylation (HP:0012345)2.21430798
77Duodenal stenosis (HP:0100867)2.21041674
78Small intestinal stenosis (HP:0012848)2.21041674
79True hermaphroditism (HP:0010459)2.20138575
80Increased muscle lipid content (HP:0009058)2.17583855
81Rough bone trabeculation (HP:0100670)2.17096978
82Abnormality of renal resorption (HP:0011038)2.14561079
83Neoplasm of the adrenal gland (HP:0100631)2.11945169
84Nephrogenic diabetes insipidus (HP:0009806)2.10393478
85Congenital primary aphakia (HP:0007707)2.05944132
86Abnormality of the duodenum (HP:0002246)2.01268088
87Pancreatic cysts (HP:0001737)1.99240152
88Gait imbalance (HP:0002141)1.98408571
89Pancreatic islet-cell hyperplasia (HP:0004510)1.95495556
90Abnormality of glycine metabolism (HP:0010895)1.95078912
91Abnormality of serine family amino acid metabolism (HP:0010894)1.95078912
92CNS demyelination (HP:0007305)1.93045837
93Abnormal hair whorl (HP:0010721)1.92201238
94Bifid tongue (HP:0010297)1.90503666
95Rhabdomyosarcoma (HP:0002859)1.89742676
96Ependymoma (HP:0002888)1.89081056
97Horseshoe kidney (HP:0000085)1.87454138
98Aplasia/hypoplasia of the uterus (HP:0008684)1.87264772
99Congenital ichthyosiform erythroderma (HP:0007431)1.87203797
100Hyperglycinuria (HP:0003108)1.87175850
101Abnormality of the pons (HP:0007361)1.86818240
102Muscle fiber atrophy (HP:0100295)1.86120558
103Sloping forehead (HP:0000340)1.85914387
104Hypoplastic pelvis (HP:0008839)1.84868824
105Congenital, generalized hypertrichosis (HP:0004540)1.84045702
106Molar tooth sign on MRI (HP:0002419)1.82732333
107Abnormality of midbrain morphology (HP:0002418)1.82732333
108Triphalangeal thumb (HP:0001199)1.81009211
109Premature graying of hair (HP:0002216)1.80773816
110Pancytopenia (HP:0001876)1.79774822
111Amniotic constriction ring (HP:0009775)1.79741306
112Abnormality of placental membranes (HP:0011409)1.79741306
113Median cleft lip (HP:0000161)1.78805702
114Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78556349
115Abnormality of the vitamin B12 metabolism (HP:0004341)1.78314377
116Severe visual impairment (HP:0001141)1.78234304
117Hypoplasia of the pons (HP:0012110)1.77283207
118Abnormal trabecular bone morphology (HP:0100671)1.76885573
119Volvulus (HP:0002580)1.76522885
120Aplasia/Hypoplasia of the tibia (HP:0005772)1.75944590
121Abnormal lung lobation (HP:0002101)1.75438397
122Myelodysplasia (HP:0002863)1.74815921
123Absent epiphyses (HP:0010577)1.73622883
124Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73622883
125X-linked dominant inheritance (HP:0001423)1.72464613
126Poor head control (HP:0002421)1.67774984
127Sparse eyelashes (HP:0000653)1.67553885
128Emotional lability (HP:0000712)1.67247967
129Carpal bone hypoplasia (HP:0001498)1.66598836
130Cleft eyelid (HP:0000625)1.64777733
131Adrenal hypoplasia (HP:0000835)1.63676755
132Patchy hypopigmentation of hair (HP:0011365)1.63326171
133Poor suck (HP:0002033)1.63296467
134Abnormal pupillary function (HP:0007686)1.61746145
135Abnormality of the axillary hair (HP:0100134)1.61268958
136Abnormality of secondary sexual hair (HP:0009888)1.61268958
137Postnatal microcephaly (HP:0005484)1.60939316
138Abnormality of urine glucose concentration (HP:0011016)1.59322671
139Glycosuria (HP:0003076)1.59322671
140Abnormality of the preputium (HP:0100587)1.58881370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.15961401
2VRK23.54385842
3BUB13.40676646
4EIF2AK13.21852405
5CASK2.69719776
6NEK12.65493978
7EIF2AK32.61068811
8NME22.59011894
9TRIM282.50893489
10SRPK12.49688005
11WEE12.39741262
12NME12.37499833
13PBK2.32514366
14VRK12.28325212
15MKNK12.22249604
16TNIK2.14476304
17NUAK12.05617908
18MAP3K121.91771513
19PIM21.77768221
20MST41.76769434
21ACVR1B1.76723877
22PLK41.76352165
23BMPR1B1.75813292
24TAF11.73187624
25MKNK21.72669780
26TSSK61.70486087
27BCR1.59354417
28MAP4K21.58393994
29CDK81.40180159
30BRSK21.39707750
31AKT31.35998176
32EIF2AK21.34804310
33MAP2K71.31630391
34CCNB11.31494072
35ZAK1.26959278
36PLK31.23883107
37PLK21.23525888
38BMPR21.23443416
39ERBB31.22865782
40CDC71.19856704
41BRAF1.19705998
42TLK11.16719079
43ARAF1.16440542
44CDK191.16378515
45PDK21.16255174
46LIMK11.15022047
47DYRK21.12778001
48ADRBK21.07938364
49SIK30.98876876
50YES10.97901246
51CSNK1G10.97456060
52AURKA0.92528042
53MYLK0.92101648
54IRAK40.90751792
55GRK70.86715483
56TESK20.86079200
57FRK0.86038560
58MAPK130.84601145
59MUSK0.82264259
60DYRK30.80695161
61GRK10.80627861
62PLK10.79916854
63TXK0.78466443
64CSNK1G20.76542918
65STK40.76466766
66OBSCN0.76002561
67CSNK1A1L0.72009953
68PAK40.71375652
69TGFBR10.69405523
70OXSR10.68634810
71ABL20.65846152
72* CSNK2A10.65171310
73MAP3K40.65093218
74ERBB40.63759872
75STK30.63274891
76TESK10.62235252
77NEK60.61806977
78AURKB0.61634677
79TEC0.60461178
80ATM0.57962147
81RPS6KA40.56832169
82PASK0.56214992
83STK240.56151766
84PNCK0.55957893
85KDR0.55115608
86IRAK30.54860517
87BRSK10.54525720
88CSNK1G30.52852636
89* CSNK2A20.52191195
90STK100.51985414
91DAPK10.50678664
92CHEK10.50534150
93ADRBK10.49968413
94CDK70.49703277
95ATR0.48381473
96MAPKAPK50.48373561
97NEK20.47201544
98CDK30.46455098
99PRPF4B0.46298349
100RPS6KA50.45463221
101ALK0.44405963
102STK38L0.40753045
103MAP3K140.40162552
104INSRR0.37424741
105FGFR10.37337220
106RPS6KB20.37222905
107CHEK20.37102108
108MARK10.36906017
109IRAK10.35390357
110CAMK2B0.35338458
111CSNK1E0.34979484
112BCKDK0.34661077
113LYN0.33261938
114STK390.33188166
115MAP3K80.32096298
116GRK50.31790640
117WNK30.30309676
118PRKCI0.29242128
119CAMKK20.29216824
120TTK0.28097467
121PINK10.27996480
122PRKCE0.27787343
123PRKCG0.26723051
124EPHA20.26703853
125NLK0.26692282
126CDK10.26435891
127CLK10.26176172
128PAK10.25851357
129FLT30.23808360
130IKBKB0.23669123
131CSNK1A10.23567140
132SCYL20.23519486
133CDK90.22489248
134MINK10.20172343

Predicted pathways (KEGG)

RankGene SetZ-score
1* Proteasome_Homo sapiens_hsa030505.12054017
2Ribosome_Homo sapiens_hsa030104.05622058
3Oxidative phosphorylation_Homo sapiens_hsa001903.87583454
4RNA polymerase_Homo sapiens_hsa030203.68578909
5Parkinsons disease_Homo sapiens_hsa050123.33310624
6Protein export_Homo sapiens_hsa030603.30177100
7DNA replication_Homo sapiens_hsa030303.01667875
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.61506195
9Mismatch repair_Homo sapiens_hsa034302.58605750
10Huntingtons disease_Homo sapiens_hsa050162.53642911
11Pyrimidine metabolism_Homo sapiens_hsa002402.43610554
12Spliceosome_Homo sapiens_hsa030402.34677488
13Alzheimers disease_Homo sapiens_hsa050102.31879816
14Homologous recombination_Homo sapiens_hsa034402.25992010
15Nucleotide excision repair_Homo sapiens_hsa034202.22111284
16Base excision repair_Homo sapiens_hsa034101.88732572
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.84424895
18Basal transcription factors_Homo sapiens_hsa030221.83648412
19RNA transport_Homo sapiens_hsa030131.74620175
20Propanoate metabolism_Homo sapiens_hsa006401.74564791
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74285888
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69146636
23Non-homologous end-joining_Homo sapiens_hsa034501.61046312
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49180466
25Purine metabolism_Homo sapiens_hsa002301.48249657
26RNA degradation_Homo sapiens_hsa030181.44870554
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42210401
28Fanconi anemia pathway_Homo sapiens_hsa034601.39435796
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38808351
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35714250
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30458473
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25238181
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19840598
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17150686
35Collecting duct acid secretion_Homo sapiens_hsa049661.15839142
36Cell cycle_Homo sapiens_hsa041101.14382803
37One carbon pool by folate_Homo sapiens_hsa006701.06767044
38Selenocompound metabolism_Homo sapiens_hsa004501.02638037
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99631224
40Vibrio cholerae infection_Homo sapiens_hsa051100.93070201
41Epstein-Barr virus infection_Homo sapiens_hsa051690.91047220
42Cardiac muscle contraction_Homo sapiens_hsa042600.90309612
43Fatty acid elongation_Homo sapiens_hsa000620.87075723
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85943310
45Biosynthesis of amino acids_Homo sapiens_hsa012300.82701751
46Folate biosynthesis_Homo sapiens_hsa007900.80482715
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78632195
48Allograft rejection_Homo sapiens_hsa053300.78112352
49Steroid biosynthesis_Homo sapiens_hsa001000.77617891
50Butanoate metabolism_Homo sapiens_hsa006500.77045902
51Rheumatoid arthritis_Homo sapiens_hsa053230.76352983
52Glutathione metabolism_Homo sapiens_hsa004800.75939395
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75732713
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71478265
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70374390
56Metabolic pathways_Homo sapiens_hsa011000.70033554
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68174986
58Arachidonic acid metabolism_Homo sapiens_hsa005900.65701678
59Autoimmune thyroid disease_Homo sapiens_hsa053200.64517911
60Tryptophan metabolism_Homo sapiens_hsa003800.63764480
61Caffeine metabolism_Homo sapiens_hsa002320.61897321
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.59804145
63Phototransduction_Homo sapiens_hsa047440.59519145
64Graft-versus-host disease_Homo sapiens_hsa053320.59425315
65Fatty acid degradation_Homo sapiens_hsa000710.55123966
66mRNA surveillance pathway_Homo sapiens_hsa030150.55030429
67Fatty acid metabolism_Homo sapiens_hsa012120.54925523
68Type I diabetes mellitus_Homo sapiens_hsa049400.53763388
69Phagosome_Homo sapiens_hsa041450.52811879
70p53 signaling pathway_Homo sapiens_hsa041150.52415386
71Sulfur metabolism_Homo sapiens_hsa009200.52266738
72Regulation of autophagy_Homo sapiens_hsa041400.50617832
73Legionellosis_Homo sapiens_hsa051340.50543030
74Asthma_Homo sapiens_hsa053100.49971237
75Systemic lupus erythematosus_Homo sapiens_hsa053220.49174355
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48878544
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47218208
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.45584628
79Sphingolipid metabolism_Homo sapiens_hsa006000.45249640
80Sulfur relay system_Homo sapiens_hsa041220.45106154
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44700089
82beta-Alanine metabolism_Homo sapiens_hsa004100.43057136
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.42744688
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42731063
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42235844
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40394944
87Vitamin digestion and absorption_Homo sapiens_hsa049770.40257118
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39694084
89N-Glycan biosynthesis_Homo sapiens_hsa005100.39507328
90Chemical carcinogenesis_Homo sapiens_hsa052040.37773176
91Arginine and proline metabolism_Homo sapiens_hsa003300.37436135
92Serotonergic synapse_Homo sapiens_hsa047260.37035442
93Ether lipid metabolism_Homo sapiens_hsa005650.34781713
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34603921
95Herpes simplex infection_Homo sapiens_hsa051680.34227506
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33875346
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31630069
98Nicotine addiction_Homo sapiens_hsa050330.29429920
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29353755
100Tyrosine metabolism_Homo sapiens_hsa003500.29196542
101Retinol metabolism_Homo sapiens_hsa008300.29048257
102Antigen processing and presentation_Homo sapiens_hsa046120.27848901
103Pyruvate metabolism_Homo sapiens_hsa006200.27725304
104Alcoholism_Homo sapiens_hsa050340.27273443
105Pentose phosphate pathway_Homo sapiens_hsa000300.26695395
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.26521953
107Oocyte meiosis_Homo sapiens_hsa041140.24505425
108Fat digestion and absorption_Homo sapiens_hsa049750.22827669
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22605605
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.22394380
111Hematopoietic cell lineage_Homo sapiens_hsa046400.22345219
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22040878
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21239115
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21106202
115Vitamin B6 metabolism_Homo sapiens_hsa007500.20952313
116TGF-beta signaling pathway_Homo sapiens_hsa043500.20637800
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20542576
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19742310
119Fructose and mannose metabolism_Homo sapiens_hsa000510.18842034
120Primary immunodeficiency_Homo sapiens_hsa053400.18590078
121Peroxisome_Homo sapiens_hsa041460.18303009
122Linoleic acid metabolism_Homo sapiens_hsa005910.17717616
123Nitrogen metabolism_Homo sapiens_hsa009100.17425093
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.17189347
125Phenylalanine metabolism_Homo sapiens_hsa003600.16891400
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16484493
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.16308134
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15215170
129Synaptic vesicle cycle_Homo sapiens_hsa047210.14168532
130Carbon metabolism_Homo sapiens_hsa012000.13359048
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.12319280
132Pertussis_Homo sapiens_hsa051330.12123880
133Measles_Homo sapiens_hsa051620.10434926
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.07926822

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