PSMA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.90012550
2ribosomal small subunit assembly (GO:0000028)4.75133117
3* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.66315047
4formation of translation preinitiation complex (GO:0001731)4.49549457
5* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.43827131
6* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.37488946
7* regulation of cellular amino acid metabolic process (GO:0006521)4.31987700
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.31569137
9purine nucleobase biosynthetic process (GO:0009113)4.27304137
10* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.25490894
11maturation of SSU-rRNA (GO:0030490)4.25486768
12* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.23419969
13* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.21932066
14* negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.19138811
15* negative regulation of ligase activity (GO:0051352)4.19138811
16respiratory electron transport chain (GO:0022904)4.16952165
17* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.14076651
18* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.14076651
19chaperone-mediated protein transport (GO:0072321)4.11865802
20* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.10983037
21* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.10983037
22* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.10983037
23electron transport chain (GO:0022900)4.09045886
24* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)4.06884982
25nucleobase biosynthetic process (GO:0046112)4.03045248
26* signal transduction involved in DNA integrity checkpoint (GO:0072401)4.00430810
27* signal transduction involved in DNA damage checkpoint (GO:0072422)4.00430810
28* signal transduction involved in cell cycle checkpoint (GO:0072395)3.94575354
29cullin deneddylation (GO:0010388)3.91848562
30* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.86774267
31protein complex biogenesis (GO:0070271)3.86404506
32mitochondrial respiratory chain complex assembly (GO:0033108)3.77495275
337-methylguanosine mRNA capping (GO:0006370)3.77349901
34DNA strand elongation involved in DNA replication (GO:0006271)3.76449808
35establishment of integrated proviral latency (GO:0075713)3.70604546
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.70510399
37NADH dehydrogenase complex assembly (GO:0010257)3.70510399
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.70510399
397-methylguanosine RNA capping (GO:0009452)3.70006298
40RNA capping (GO:0036260)3.70006298
41protein deneddylation (GO:0000338)3.69783098
42* positive regulation of ligase activity (GO:0051351)3.69579110
43ribosomal small subunit biogenesis (GO:0042274)3.68079280
44exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.67416727
45nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.67191872
46ribosomal large subunit biogenesis (GO:0042273)3.62528079
47ribosome biogenesis (GO:0042254)3.61514681
48telomere maintenance via semi-conservative replication (GO:0032201)3.60713493
49DNA deamination (GO:0045006)3.60686483
50termination of RNA polymerase III transcription (GO:0006386)3.59679126
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.59679126
52ribonucleoprotein complex biogenesis (GO:0022613)3.59626306
53rRNA modification (GO:0000154)3.58493409
54DNA strand elongation (GO:0022616)3.55815078
55respiratory chain complex IV assembly (GO:0008535)3.54090387
56regulation of mitochondrial translation (GO:0070129)3.52652569
57viral transcription (GO:0019083)3.51499439
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.50568986
59translational termination (GO:0006415)3.50129170
60DNA replication checkpoint (GO:0000076)3.49217296
61establishment of protein localization to mitochondrial membrane (GO:0090151)3.48808100
62CENP-A containing nucleosome assembly (GO:0034080)3.45030379
63ribosome assembly (GO:0042255)3.44619401
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.40828905
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.40828905
66telomere maintenance via recombination (GO:0000722)3.40169242
67oxidative phosphorylation (GO:0006119)3.37484589
68DNA replication initiation (GO:0006270)3.37285697
69* regulation of ubiquitin-protein transferase activity (GO:0051438)3.36860249
70* cell cycle G1/S phase transition (GO:0044843)3.35209448
71* G1/S transition of mitotic cell cycle (GO:0000082)3.35209448
72* positive regulation of cell cycle arrest (GO:0071158)3.35072317
73mitotic metaphase plate congression (GO:0007080)3.33931857
74DNA double-strand break processing (GO:0000729)3.33847875
75chromatin remodeling at centromere (GO:0031055)3.31185436
76* antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.30714965
77translational initiation (GO:0006413)3.29393117
78DNA catabolic process, exonucleolytic (GO:0000738)3.27745261
79cytochrome complex assembly (GO:0017004)3.27076533
80* DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.26694748
81* regulation of ligase activity (GO:0051340)3.24662164
82SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.24434315
83establishment of viral latency (GO:0019043)3.24371168
84translation (GO:0006412)3.23483606
85protein neddylation (GO:0045116)3.22882563
86translational elongation (GO:0006414)3.22256931
87rRNA processing (GO:0006364)3.21888589
88spliceosomal snRNP assembly (GO:0000387)3.21817791
89cotranslational protein targeting to membrane (GO:0006613)3.19959300
90termination of RNA polymerase I transcription (GO:0006363)3.18346893
91transcription-coupled nucleotide-excision repair (GO:0006283)3.18134035
92ATP synthesis coupled proton transport (GO:0015986)3.17314698
93energy coupled proton transport, down electrochemical gradient (GO:0015985)3.17314698
94transcription elongation from RNA polymerase I promoter (GO:0006362)3.17171766
95protein targeting to ER (GO:0045047)3.15261377
96mitotic recombination (GO:0006312)3.13409943
97transcription from RNA polymerase I promoter (GO:0006360)3.12003982
98* regulation of cellular amine metabolic process (GO:0033238)3.11573006
99protein localization to mitochondrion (GO:0070585)3.10225147
100cellular component biogenesis (GO:0044085)3.10190480
101rRNA metabolic process (GO:0016072)3.09093784
102rRNA methylation (GO:0031167)3.06039634
103establishment of protein localization to mitochondrion (GO:0072655)3.04162827
104maturation of 5.8S rRNA (GO:0000460)3.03709435
105protein localization to endoplasmic reticulum (GO:0070972)3.03453578
106DNA ligation (GO:0006266)3.02200928
107* negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.01732860
108deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.00181001
109guanosine-containing compound biosynthetic process (GO:1901070)2.98229289
110deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.96535459
111establishment of protein localization to endoplasmic reticulum (GO:0072599)2.96513494
112inner mitochondrial membrane organization (GO:0007007)2.92692209
113DNA damage response, detection of DNA damage (GO:0042769)2.92422614
114DNA replication-independent nucleosome organization (GO:0034724)2.91638412
115DNA replication-independent nucleosome assembly (GO:0006336)2.91638412
116purine nucleotide salvage (GO:0032261)2.91148634
117nucleobase-containing small molecule interconversion (GO:0015949)2.91008511
118nucleotide-excision repair, DNA gap filling (GO:0006297)2.88872787
119* signal transduction in response to DNA damage (GO:0042770)2.86739296
120nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.86545424
121viral mRNA export from host cell nucleus (GO:0046784)2.86445395
122histone exchange (GO:0043486)2.86358013
123* negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.84278686
124* negative regulation of cell cycle G1/S phase transition (GO:1902807)2.84278686
125kinetochore assembly (GO:0051382)2.83673588
126pseudouridine synthesis (GO:0001522)2.83555667
127kinetochore organization (GO:0051383)2.83525251
128transcription elongation from RNA polymerase II promoter (GO:0006368)2.83497607
129transcription initiation from RNA polymerase I promoter (GO:0006361)2.82985818
130protein targeting to mitochondrion (GO:0006626)2.82644629
131* negative regulation of protein ubiquitination (GO:0031397)2.82124421
132viral life cycle (GO:0019058)2.81937645

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.91686604
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.21800971
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.12191516
4* GABP_17652178_ChIP-ChIP_JURKAT_Human3.97421724
5* EST1_17652178_ChIP-ChIP_JURKAT_Human3.81465291
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.73061144
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.56920977
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.37793912
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.33365020
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.12411368
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.00025261
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.90754937
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90581428
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74644188
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.72489943
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68498145
17* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.65303730
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64668963
19* VDR_23849224_ChIP-Seq_CD4+_Human2.61499581
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.56690758
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50202660
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45923799
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40797520
24DCP1A_22483619_ChIP-Seq_HELA_Human2.33301570
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.33232210
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28789203
27* XRN2_22483619_ChIP-Seq_HELA_Human2.23057410
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22908335
29ELK1_19687146_ChIP-ChIP_HELA_Human2.18162902
30FOXP3_21729870_ChIP-Seq_TREG_Human2.08534177
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.08316867
32FOXM1_23109430_ChIP-Seq_U2OS_Human2.00773039
33* GABP_19822575_ChIP-Seq_HepG2_Human1.99000955
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89861754
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89824355
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89617298
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.86665025
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84268449
39TTF2_22483619_ChIP-Seq_HELA_Human1.79927502
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.75319870
41* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73359637
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71175281
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69924354
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64555905
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.62428011
46* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60623411
47* AR_21909140_ChIP-Seq_LNCAP_Human1.59705435
48* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58411708
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57599429
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47694046
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47128537
52* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43922561
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40721780
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40446792
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.36246522
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36233826
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.35698986
58* E2F1_21310950_ChIP-Seq_MCF-7_Human1.34080110
59* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32486565
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31886671
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29375310
62ZNF274_21170338_ChIP-Seq_K562_Hela1.26875759
63* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21516940
64KDM5A_27292631_Chip-Seq_BREAST_Human1.19551372
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18174594
66SPI1_23547873_ChIP-Seq_NB4_Human1.16446331
67* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16060501
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14529252
69BP1_19119308_ChIP-ChIP_Hs578T_Human1.13976471
70CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.13398793
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.10013767
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09043101
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07557909
74VDR_22108803_ChIP-Seq_LS180_Human1.05896891
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05605730
76CIITA_25753668_ChIP-Seq_RAJI_Human1.05302253
77* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02186676
78TFEB_21752829_ChIP-Seq_HELA_Human1.00441187
79MYC_18940864_ChIP-ChIP_HL60_Human0.99422836
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98454677
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97658622
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96504215
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96334216
84NOTCH1_21737748_ChIP-Seq_TLL_Human0.95698603
85EWS_26573619_Chip-Seq_HEK293_Human0.92743442
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90560266
87KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90237697
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89440497
89STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88441845
90* ELF5_23300383_ChIP-Seq_T47D_Human0.86835302
91NANOG_16153702_ChIP-ChIP_HESCs_Human0.85312981
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84661393
93PCGF2_27294783_Chip-Seq_ESCs_Mouse0.83005122
94EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82269311
95SOX17_20123909_ChIP-Seq_XEN_Mouse0.80669694
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79086114
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78472239
98* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77754745
99RBPJ_22232070_ChIP-Seq_NCS_Mouse0.76522465
100EGR1_19374776_ChIP-ChIP_THP-1_Human0.76231745
101OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76041111
102* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75949800
103SOX2_18555785_ChIP-Seq_MESCs_Mouse0.75035810
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74867136
105TP53_22573176_ChIP-Seq_HFKS_Human0.74197628
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.72571287
107PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.72448315
108HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.71991955
109NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71460937
110CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.69815535
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.69610700
112KAP1_22055183_ChIP-Seq_ESCs_Mouse0.68849431
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.66079297
114* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.65590779
115* FOXA1_25329375_ChIP-Seq_VCAP_Human0.65590779
116AR_20517297_ChIP-Seq_VCAP_Human0.64825437
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.64505019

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.23784519
2MP0004957_abnormal_blastocyst_morpholog3.97379795
3MP0010094_abnormal_chromosome_stability3.68257176
4MP0008057_abnormal_DNA_replication3.57055315
5MP0003077_abnormal_cell_cycle3.30490075
6MP0008058_abnormal_DNA_repair3.22209202
7MP0003111_abnormal_nucleus_morphology3.17734344
8MP0003186_abnormal_redox_activity2.72248408
9MP0001835_abnormal_antigen_presentation2.69201795
10MP0003806_abnormal_nucleotide_metabolis2.58698659
11MP0008007_abnormal_cellular_replicative2.54607331
12MP0004147_increased_porphyrin_level2.46334045
13MP0009785_altered_susceptibility_to2.41123828
14MP0002163_abnormal_gland_morphology2.39424768
15MP0008932_abnormal_embryonic_tissue2.32266954
16MP0003786_premature_aging2.27298833
17MP0002148_abnormal_hypersensitivity_rea2.25918493
18MP0003718_maternal_effect2.20926616
19MP0003195_calcinosis2.19238174
20MP0008877_abnormal_DNA_methylation2.15416535
21MP0009333_abnormal_splenocyte_physiolog2.03319881
22MP0005671_abnormal_response_to1.99273300
23MP0008875_abnormal_xenobiotic_pharmacok1.96644033
24MP0001853_heart_inflammation1.80603052
25MP0000685_abnormal_immune_system1.78947790
26MP0001730_embryonic_growth_arrest1.71151683
27MP0006036_abnormal_mitochondrial_physio1.69034943
28MP0003123_paternal_imprinting1.64567909
29MP0002396_abnormal_hematopoietic_system1.63585750
30MP0000350_abnormal_cell_proliferation1.58363026
31MP0006035_abnormal_mitochondrial_morpho1.54648433
32MP0008260_abnormal_autophagy1.53579922
33MP0002102_abnormal_ear_morphology1.49802385
34MP0006072_abnormal_retinal_apoptosis1.49570081
35MP0005025_abnormal_response_to1.48936135
36MP0001545_abnormal_hematopoietic_system1.48115046
37MP0005397_hematopoietic_system_phenotyp1.48115046
38MP0005000_abnormal_immune_tolerance1.45437807
39MP0009697_abnormal_copulation1.44750892
40MP0003950_abnormal_plasma_membrane1.43917362
41MP0003436_decreased_susceptibility_to1.40877585
42MP0005075_abnormal_melanosome_morpholog1.39118414
43MP0002837_dystrophic_cardiac_calcinosis1.38996078
44MP0005084_abnormal_gallbladder_morpholo1.37793548
45MP0002132_abnormal_respiratory_system1.35911918
46MP0002019_abnormal_tumor_incidence1.32704479
47MP0002138_abnormal_hepatobiliary_system1.31573967
48MP0002398_abnormal_bone_marrow1.30229004
49MP0002139_abnormal_hepatobiliary_system1.30168152
50MP0002452_abnormal_antigen_presenting1.29593443
51MP0000313_abnormal_cell_death1.29190494
52MP0002723_abnormal_immune_serum1.28842590
53MP0001819_abnormal_immune_cell1.26785651
54MP0002420_abnormal_adaptive_immunity1.24509605
55MP0009764_decreased_sensitivity_to1.24327079
56MP0000490_abnormal_crypts_of1.24167934
57MP0003724_increased_susceptibility_to1.23630075
58MP0001764_abnormal_homeostasis1.22772793
59MP0003763_abnormal_thymus_physiology1.22227682
60MP0001800_abnormal_humoral_immune1.21999688
61MP0006054_spinal_hemorrhage1.21580220
62MP0002938_white_spotting1.20105407
63MP0002419_abnormal_innate_immunity1.18280574
64MP0008872_abnormal_physiological_respon1.18120964
65MP0006292_abnormal_olfactory_placode1.17400411
66MP0001542_abnormal_bone_strength1.16778716
67MP0003011_delayed_dark_adaptation1.16186761
68MP0000716_abnormal_immune_system1.15579724
69MP0000689_abnormal_spleen_morphology1.15132437
70MP0002722_abnormal_immune_system1.14699151
71MP0002429_abnormal_blood_cell1.13207197
72MP0002006_tumorigenesis1.11870792
73MP0002210_abnormal_sex_determination1.11571419
74MP0000358_abnormal_cell_content/1.10689563
75MP0003941_abnormal_skin_development1.08884705
76MP0005387_immune_system_phenotype1.06573802
77MP0001790_abnormal_immune_system1.06573802
78MP0003221_abnormal_cardiomyocyte_apopto1.06303818
79MP0000372_irregular_coat_pigmentation1.06289893
80MP0006082_CNS_inflammation1.05126372
81MP0000858_altered_metastatic_potential1.04738209
82MP0010307_abnormal_tumor_latency1.04059701
83MP0002277_abnormal_respiratory_mucosa1.01993342
84MP0001697_abnormal_embryo_size1.01263539
85MP0005636_abnormal_mineral_homeostasis1.00954280
86MP0001529_abnormal_vocalization0.98898845
87MP0001727_abnormal_embryo_implantation0.98004549
88MP0004808_abnormal_hematopoietic_stem0.97781122
89MP0002080_prenatal_lethality0.97687729
90MP0001881_abnormal_mammary_gland0.97110625
91MP0009379_abnormal_foot_pigmentation0.96992713
92MP0008995_early_reproductive_senescence0.96188912
93MP0002736_abnormal_nociception_after0.95685523
94MP0005379_endocrine/exocrine_gland_phen0.95433525
95MP0005410_abnormal_fertilization0.94482565
96MP0001929_abnormal_gametogenesis0.94233331
97MP0002405_respiratory_system_inflammati0.93191056
98MP0002160_abnormal_reproductive_system0.92664092
99MP0001145_abnormal_male_reproductive0.92616725
100MP0008469_abnormal_protein_level0.92227050
101MP0005332_abnormal_amino_acid0.92190641
102MP0005380_embryogenesis_phenotype0.91168263
103MP0001672_abnormal_embryogenesis/_devel0.91168263
104MP0003890_abnormal_embryonic-extraembry0.89683830
105MP0005408_hypopigmentation0.89594286
106MP0001919_abnormal_reproductive_system0.89488726
107MP0001845_abnormal_inflammatory_respons0.88793721
108MP0005451_abnormal_body_composition0.88207296
109MP0005319_abnormal_enzyme/_coenzyme0.87829550
110MP0003567_abnormal_fetal_cardiomyocyte0.87654798
111MP0001293_anophthalmia0.86516704
112MP0005266_abnormal_metabolism0.86141717
113MP0010352_gastrointestinal_tract_polyps0.85537846
114MP0003984_embryonic_growth_retardation0.85461254
115MP0002166_altered_tumor_susceptibility0.84066265
116MP0008873_increased_physiological_sensi0.82391838
117MP0000703_abnormal_thymus_morphology0.81230925
118MP0002088_abnormal_embryonic_growth/wei0.80070685
119MP0002876_abnormal_thyroid_physiology0.77387382
120MP0001348_abnormal_lacrimal_gland0.77303046
121MP0005389_reproductive_system_phenotype0.77051206
122MP0001346_abnormal_lacrimal_gland0.76251806
123MP0003646_muscle_fatigue0.76145934
124MP0004782_abnormal_surfactant_physiolog0.75568688
125MP0000653_abnormal_sex_gland0.74987104
126MP0003315_abnormal_perineum_morphology0.74464076
127MP0002090_abnormal_vision0.73648590
128MP0005365_abnormal_bile_salt0.73548957
129MP0001119_abnormal_female_reproductive0.73138569
130MP0003448_altered_tumor_morphology0.72491290
131MP0003121_genomic_imprinting0.72154406
132MP0004215_abnormal_myocardial_fiber0.70280999
133MP0002254_reproductive_system_inflammat0.69833493
134MP0001666_abnormal_nutrient_absorption0.69338726
135MP0001873_stomach_inflammation0.69137884
136MP0001905_abnormal_dopamine_level0.68558340
137MP0005085_abnormal_gallbladder_physiolo0.68005116
138MP0008789_abnormal_olfactory_epithelium0.67825974
139MP0003252_abnormal_bile_duct0.67301787
140MP0005165_increased_susceptibility_to0.66851340
141MP0005395_other_phenotype0.66065475
142MP0005584_abnormal_enzyme/coenzyme_acti0.65580684

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.36983685
2Abnormality of cells of the erythroid lineage (HP:0012130)4.28692860
3Abnormal number of erythroid precursors (HP:0012131)4.04708025
4Acute necrotizing encephalopathy (HP:0006965)4.00597219
5Reticulocytopenia (HP:0001896)3.74520665
6Abnormal mitochondria in muscle tissue (HP:0008316)3.69941995
7Mitochondrial inheritance (HP:0001427)3.62943550
8Increased CSF lactate (HP:0002490)3.49709373
9Breast hypoplasia (HP:0003187)3.43509239
10Abnormality of glycolysis (HP:0004366)3.28548515
11Increased serum pyruvate (HP:0003542)3.28548515
12Hepatocellular necrosis (HP:0001404)3.25608006
13Acute encephalopathy (HP:0006846)3.19529519
14Progressive macrocephaly (HP:0004481)3.17342235
15Increased hepatocellular lipid droplets (HP:0006565)3.12090199
16Hepatic necrosis (HP:0002605)3.10308041
17Cerebral hypomyelination (HP:0006808)3.07357196
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.05954063
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.05954063
20Carpal bone hypoplasia (HP:0001498)3.03606064
21Abnormality of the anterior horn cell (HP:0006802)3.03587596
22Degeneration of anterior horn cells (HP:0002398)3.03587596
23Oral leukoplakia (HP:0002745)3.02596104
24Aplastic anemia (HP:0001915)2.99779779
25Increased serum lactate (HP:0002151)2.96671285
26Microvesicular hepatic steatosis (HP:0001414)2.91624079
273-Methylglutaconic aciduria (HP:0003535)2.85197854
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.84929723
29Multiple enchondromatosis (HP:0005701)2.82611200
30Macrocytic anemia (HP:0001972)2.79482123
31Rough bone trabeculation (HP:0100670)2.77754340
32Lipid accumulation in hepatocytes (HP:0006561)2.77578602
33Increased IgM level (HP:0003496)2.71311267
34Optic disc pallor (HP:0000543)2.70280034
35Exertional dyspnea (HP:0002875)2.69224972
36Lethargy (HP:0001254)2.69170632
37Generalized aminoaciduria (HP:0002909)2.65659491
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.60448152
39Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.58698343
40Abnormal protein N-linked glycosylation (HP:0012347)2.58698343
41Abnormal protein glycosylation (HP:0012346)2.58698343
42Abnormal glycosylation (HP:0012345)2.58698343
43Exercise intolerance (HP:0003546)2.55353562
44Pallor (HP:0000980)2.53162994
45Abnormality of methionine metabolism (HP:0010901)2.50603154
46B lymphocytopenia (HP:0010976)2.47828868
47Respiratory difficulties (HP:0002880)2.46599500
48Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.46271509
49Abnormality of B cell number (HP:0010975)2.45642865
50Cleft eyelid (HP:0000625)2.42803259
51Microretrognathia (HP:0000308)2.42492911
52Type I transferrin isoform profile (HP:0003642)2.40503986
53Lactic acidosis (HP:0003128)2.37826101
54Poor head control (HP:0002421)2.37248232
55Respiratory failure (HP:0002878)2.35228749
56Patellar aplasia (HP:0006443)2.34682557
57Renal Fanconi syndrome (HP:0001994)2.33182477
58Abnormal spermatogenesis (HP:0008669)2.31960706
59Trismus (HP:0000211)2.31521948
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.30537757
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.29055702
62Methylmalonic aciduria (HP:0012120)2.28901745
63Cerebral edema (HP:0002181)2.26408522
64Type 2 muscle fiber atrophy (HP:0003554)2.24435161
65Impulsivity (HP:0100710)2.22814102
66Methylmalonic acidemia (HP:0002912)2.22013299
67Aplasia/Hypoplasia of the patella (HP:0006498)2.21737016
68Colon cancer (HP:0003003)2.21089470
69Muscle fiber atrophy (HP:0100295)2.18955243
70Secondary amenorrhea (HP:0000869)2.18392693
71Abnormal trabecular bone morphology (HP:0100671)2.17452113
72Increased intramyocellular lipid droplets (HP:0012240)2.15935166
73Abnormality of serum amino acid levels (HP:0003112)2.13179406
74Meckel diverticulum (HP:0002245)2.12502886
75Abnormality of renal resorption (HP:0011038)2.11070551
76CNS demyelination (HP:0007305)2.10613830
77Recurrent abscess formation (HP:0002722)2.10452056
78Abnormality of the preputium (HP:0100587)2.09847769
79Sparse eyelashes (HP:0000653)2.09516786
80Amniotic constriction ring (HP:0009775)2.09493668
81Abnormality of placental membranes (HP:0011409)2.09493668
82Chromsome breakage (HP:0040012)2.08235655
83Absent thumb (HP:0009777)2.08211254
84Pancytopenia (HP:0001876)2.05733715
85Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04484258
86Granulocytopenia (HP:0001913)2.04393249
87Agnosia (HP:0010524)2.04273900
88Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.04240846
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00696841
90Abnormality of alanine metabolism (HP:0010916)2.00696841
91Hyperalaninemia (HP:0003348)2.00696841
92Reduced antithrombin III activity (HP:0001976)2.00527706
93Glossoptosis (HP:0000162)1.99913097
94Glycosuria (HP:0003076)1.99374383
95Abnormality of urine glucose concentration (HP:0011016)1.99374383
96Bone marrow hypocellularity (HP:0005528)1.98577568
97Cellular immunodeficiency (HP:0005374)1.98114223
98Abnormality of the ileum (HP:0001549)1.97788783
99Prolonged neonatal jaundice (HP:0006579)1.97233486
100CNS hypomyelination (HP:0003429)1.97091171
101Thrombocytosis (HP:0001894)1.96997722
102IgG deficiency (HP:0004315)1.95546067
103Congenital ichthyosiform erythroderma (HP:0007431)1.95080057
104Nausea (HP:0002018)1.93926138
105Premature graying of hair (HP:0002216)1.93183576
106Emotional lability (HP:0000712)1.91688693
107X-linked dominant inheritance (HP:0001423)1.91167789
108Leukodystrophy (HP:0002415)1.91123188
109Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88499322
110Abnormality of chromosome stability (HP:0003220)1.88128386
111Elevated erythrocyte sedimentation rate (HP:0003565)1.87501254
112Irregular epiphyses (HP:0010582)1.86354678
113Hypoplasia of the capital femoral epiphysis (HP:0003090)1.85295107
114Increased muscle lipid content (HP:0009058)1.85069505
115Postnatal microcephaly (HP:0005484)1.84641839
116Stenosis of the external auditory canal (HP:0000402)1.82727723
117Abnormality of the pons (HP:0007361)1.82484767
118Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82003918
119Dicarboxylic aciduria (HP:0003215)1.82003918
120Recurrent bacterial skin infections (HP:0005406)1.81989244
121Duodenal stenosis (HP:0100867)1.81448855
122Small intestinal stenosis (HP:0012848)1.81448855
123Absent radius (HP:0003974)1.81082658
124Testicular atrophy (HP:0000029)1.80748858
125Selective tooth agenesis (HP:0001592)1.79947483
126Premature ovarian failure (HP:0008209)1.78990592
127Autoimmune thrombocytopenia (HP:0001973)1.78551433
128Congenital, generalized hypertrichosis (HP:0004540)1.78420771
129Petechiae (HP:0000967)1.78091210
130Eosinophilia (HP:0001880)1.77656195
131Palpitations (HP:0001962)1.76361299
132Hypothermia (HP:0002045)1.75137531
133Blindness (HP:0000618)1.72742971
134Posterior subcapsular cataract (HP:0007787)1.71513351
135Combined immunodeficiency (HP:0005387)1.70468187
136Neoplasm of the adrenal gland (HP:0100631)1.69028138
137Hypoplasia of the pons (HP:0012110)1.68694241
138Delayed CNS myelination (HP:0002188)1.66914637
139Pancreatic cysts (HP:0001737)1.66896797
140Pancreatic islet-cell hyperplasia (HP:0004510)1.65170006
141Myelodysplasia (HP:0002863)1.63764738

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.66287712
2EIF2AK14.07011447
3VRK24.01816466
4WEE13.79664165
5NME23.56453300
6STK163.13865037
7EIF2AK32.91326462
8PBK2.70944348
9SRPK12.45940243
10ACVR1B2.32699189
11PIM22.18696601
12PLK42.13478563
13CDC72.08874005
14TSSK62.08673940
15MST42.07156517
16VRK11.89811876
17BRSK21.87388078
18NEK11.83598697
19TESK11.80690946
20TRIM281.75613347
21MKNK11.51315704
22ARAF1.49370379
23TESK21.46926051
24PLK11.44097013
25PLK31.42597556
26NME11.33675789
27EIF2AK21.29925306
28SCYL21.28360625
29NEK21.26053245
30MAP3K141.25354812
31BCR1.24297661
32PDK41.22657573
33PDK31.22657573
34TAF11.22459566
35MAP4K21.22274153
36DYRK31.20529542
37ZAK1.19339354
38IRAK41.12267659
39KDR1.12240605
40ADRBK21.12115041
41WNK31.10792911
42AURKB1.10300836
43BRAF1.09361323
44LIMK11.06669819
45BRSK11.05506196
46TTK1.02466506
47RPS6KA41.01028841
48AURKA0.99945910
49DAPK10.97384713
50CCNB10.95286358
51PDK20.95261264
52PASK0.94556422
53ABL20.94218589
54ATR0.89908269
55FLT30.87881165
56MKNK20.87632160
57CSNK1G30.87425916
58IKBKB0.87185453
59STK40.86636271
60PIM10.80841642
61CDK70.80250376
62TGFBR10.80172810
63MAP3K120.79084298
64IRAK30.77997613
65CSNK2A10.76208816
66PLK20.74052376
67JAK30.73301333
68RPS6KB20.72411257
69STK240.72108637
70BCKDK0.71191828
71ERBB40.70933404
72CHEK20.70573156
73CSNK1G10.69925086
74EPHA20.69396576
75GRK10.69341601
76TLK10.69337761
77TYK20.69181468
78MST1R0.68472968
79PAK10.68187711
80DYRK20.67924575
81CDK40.67633835
82MAP3K80.67609395
83TBK10.67374121
84CSNK2A20.62704067
85CSNK1G20.61151910
86PAK40.59701505
87CSNK1A1L0.59540966
88BLK0.58853925
89GRK70.57236319
90BMPR20.55637655
91CHEK10.55154694
92TXK0.55109063
93KIT0.55023455
94CDK80.54402883
95MAPKAPK50.54398317
96ILK0.54074252
97TEC0.52801213
98OXSR10.52678916
99MAP3K110.51939891
100MYLK0.51545754
101AKT30.50881408
102NUAK10.50014090
103ERBB30.49450262
104NEK90.49336630
105SYK0.48338573
106YES10.45687877
107ATM0.43373756
108WNK40.43024669
109BMPR1B0.42439118
110STK38L0.42312369
111OBSCN0.41750483
112INSRR0.41359508
113DAPK30.41341924
114CLK10.41247095
115RPS6KA50.41078873
116PNCK0.40744003
117STK390.39344640
118BTK0.39034644
119MAP2K70.38710408
120MAPKAPK30.37942700
121TAOK30.37901199
122ZAP700.37589368
123STK100.36987168
124ALK0.36889146
125SIK30.35127195
126LYN0.34746422
127LRRK20.33706040
128NLK0.33655268
129CHUK0.32433143
130PRKCI0.31335607
131MATK0.27989349
132CSNK1A10.27188835

Predicted pathways (KEGG)

RankGene SetZ-score
1* Proteasome_Homo sapiens_hsa030505.59491834
2Ribosome_Homo sapiens_hsa030103.80835272
3RNA polymerase_Homo sapiens_hsa030203.65678891
4DNA replication_Homo sapiens_hsa030303.62020551
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.25815298
6Mismatch repair_Homo sapiens_hsa034302.97788679
7Spliceosome_Homo sapiens_hsa030402.60849560
8Pyrimidine metabolism_Homo sapiens_hsa002402.51658272
9RNA transport_Homo sapiens_hsa030132.38286786
10Nucleotide excision repair_Homo sapiens_hsa034202.33471412
11Homologous recombination_Homo sapiens_hsa034402.25715524
12Base excision repair_Homo sapiens_hsa034102.16223426
13Oxidative phosphorylation_Homo sapiens_hsa001902.14264852
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.06144505
15Parkinsons disease_Homo sapiens_hsa050122.04453883
16Basal transcription factors_Homo sapiens_hsa030221.87554647
17Protein export_Homo sapiens_hsa030601.82792641
18Allograft rejection_Homo sapiens_hsa053301.79038625
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65903392
20One carbon pool by folate_Homo sapiens_hsa006701.65885812
21Cell cycle_Homo sapiens_hsa041101.65020645
22Huntingtons disease_Homo sapiens_hsa050161.64956583
23Graft-versus-host disease_Homo sapiens_hsa053321.55034279
24Non-homologous end-joining_Homo sapiens_hsa034501.49388201
25Purine metabolism_Homo sapiens_hsa002301.40121394
26RNA degradation_Homo sapiens_hsa030181.37031175
27Propanoate metabolism_Homo sapiens_hsa006401.33741976
28Fanconi anemia pathway_Homo sapiens_hsa034601.26971735
29Vitamin B6 metabolism_Homo sapiens_hsa007501.26585114
30Epstein-Barr virus infection_Homo sapiens_hsa051691.26368682
31Fatty acid elongation_Homo sapiens_hsa000621.22486711
32Legionellosis_Homo sapiens_hsa051341.19833205
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18325960
34Alzheimers disease_Homo sapiens_hsa050101.14688991
35p53 signaling pathway_Homo sapiens_hsa041151.12680394
36Sulfur metabolism_Homo sapiens_hsa009201.11414878
37Pentose phosphate pathway_Homo sapiens_hsa000301.09227344
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08354984
39Folate biosynthesis_Homo sapiens_hsa007901.02237959
40Type I diabetes mellitus_Homo sapiens_hsa049401.01979164
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01841651
42Autoimmune thyroid disease_Homo sapiens_hsa053201.01685298
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00837585
44Intestinal immune network for IgA production_Homo sapiens_hsa046720.94796059
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94106254
46Antigen processing and presentation_Homo sapiens_hsa046120.93899304
47Peroxisome_Homo sapiens_hsa041460.91744300
48Glutathione metabolism_Homo sapiens_hsa004800.91554686
49Herpes simplex infection_Homo sapiens_hsa051680.90173502
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90087930
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.90046619
52mRNA surveillance pathway_Homo sapiens_hsa030150.84200330
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81544549
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81142296
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.80111279
56Caffeine metabolism_Homo sapiens_hsa002320.71111264
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68764386
58Asthma_Homo sapiens_hsa053100.68152711
59Regulation of autophagy_Homo sapiens_hsa041400.67146301
60Carbon metabolism_Homo sapiens_hsa012000.65699714
61Rheumatoid arthritis_Homo sapiens_hsa053230.64421106
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63043431
63Tryptophan metabolism_Homo sapiens_hsa003800.60544018
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60212074
65Measles_Homo sapiens_hsa051620.59280634
66Biosynthesis of amino acids_Homo sapiens_hsa012300.58873318
67Primary immunodeficiency_Homo sapiens_hsa053400.56984774
68Systemic lupus erythematosus_Homo sapiens_hsa053220.56712484
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55287705
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.53678728
71N-Glycan biosynthesis_Homo sapiens_hsa005100.53192392
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52361945
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52173755
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.51605791
75Fructose and mannose metabolism_Homo sapiens_hsa000510.51240749
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51214545
77Chemical carcinogenesis_Homo sapiens_hsa052040.50976809
78Metabolic pathways_Homo sapiens_hsa011000.50440529
79Butanoate metabolism_Homo sapiens_hsa006500.48892956
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47496997
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47484730
82Arachidonic acid metabolism_Homo sapiens_hsa005900.47152913
83Shigellosis_Homo sapiens_hsa051310.45218684
84Fatty acid degradation_Homo sapiens_hsa000710.45128063
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44856484
86Sulfur relay system_Homo sapiens_hsa041220.44733331
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43886188
88Influenza A_Homo sapiens_hsa051640.43344640
89Viral carcinogenesis_Homo sapiens_hsa052030.42827919
90Leishmaniasis_Homo sapiens_hsa051400.40806540
91Selenocompound metabolism_Homo sapiens_hsa004500.40312742
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39689203
93Oocyte meiosis_Homo sapiens_hsa041140.39524870
94Apoptosis_Homo sapiens_hsa042100.37891309
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37847409
96Fatty acid metabolism_Homo sapiens_hsa012120.37603347
97Vitamin digestion and absorption_Homo sapiens_hsa049770.37501960
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37121787
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37055003
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37020700
101Phagosome_Homo sapiens_hsa041450.36270953
102Phototransduction_Homo sapiens_hsa047440.36104318
103Pertussis_Homo sapiens_hsa051330.33119049
104Nitrogen metabolism_Homo sapiens_hsa009100.31877725
105Viral myocarditis_Homo sapiens_hsa054160.31776561
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31287790
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30665570
108Mineral absorption_Homo sapiens_hsa049780.30185086
109Phenylalanine metabolism_Homo sapiens_hsa003600.29200991
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28914441
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28576779
112Retinol metabolism_Homo sapiens_hsa008300.28448250
113African trypanosomiasis_Homo sapiens_hsa051430.28213590
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27175174
115Renin-angiotensin system_Homo sapiens_hsa046140.26449198
116Fat digestion and absorption_Homo sapiens_hsa049750.25118943
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24172484
118Toll-like receptor signaling pathway_Homo sapiens_hsa046200.24058606
119Collecting duct acid secretion_Homo sapiens_hsa049660.22990118
120Cardiac muscle contraction_Homo sapiens_hsa042600.22981984
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.22169461
122Pyruvate metabolism_Homo sapiens_hsa006200.21873399
123Malaria_Homo sapiens_hsa051440.21640419
124Hematopoietic cell lineage_Homo sapiens_hsa046400.21439140
125HTLV-I infection_Homo sapiens_hsa051660.21054648
126Steroid biosynthesis_Homo sapiens_hsa001000.19898194
127Tyrosine metabolism_Homo sapiens_hsa003500.19554388
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19510230

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