PSMA6P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.44638136
2RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.44638136
3DNA deamination (GO:0045006)5.25059192
4cytidine metabolic process (GO:0046087)4.52041325
5cytidine catabolic process (GO:0006216)4.52041325
6cytidine deamination (GO:0009972)4.52041325
7proteasome assembly (GO:0043248)4.48563676
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.34600838
9adenosine metabolic process (GO:0046085)4.25617893
10respiratory chain complex IV assembly (GO:0008535)4.10679000
11regulation of cellular amino acid metabolic process (GO:0006521)3.94440592
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.84506950
13DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.79704943
14protein complex biogenesis (GO:0070271)3.79235664
15platelet dense granule organization (GO:0060155)3.72420123
16pyrimidine ribonucleoside catabolic process (GO:0046133)3.70568947
17rRNA modification (GO:0000154)3.69450334
18intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.66834779
19signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.66834779
20signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.66182832
21signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.66182832
22signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.66182832
23positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.62363896
24purine nucleotide salvage (GO:0032261)3.61024206
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.56907667
26cullin deneddylation (GO:0010388)3.56590033
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.51203453
28NADH dehydrogenase complex assembly (GO:0010257)3.51203453
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.51203453
30protein deneddylation (GO:0000338)3.50022248
31ATP synthesis coupled proton transport (GO:0015986)3.45777441
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.45777441
33negative regulation of ligase activity (GO:0051352)3.45221087
34negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.45221087
35signal transduction involved in DNA integrity checkpoint (GO:0072401)3.42840095
36signal transduction involved in DNA damage checkpoint (GO:0072422)3.42840095
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.42251974
38sequestering of actin monomers (GO:0042989)3.40913784
39cytochrome complex assembly (GO:0017004)3.39573869
40mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38759476
41signal transduction involved in cell cycle checkpoint (GO:0072395)3.38746268
42mitochondrial respiratory chain complex assembly (GO:0033108)3.33305115
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.32023584
44antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.21026206
45rRNA methylation (GO:0031167)3.15905257
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.11849359
47respiratory electron transport chain (GO:0022904)3.08268155
48positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.07677458
49electron transport chain (GO:0022900)3.06589498
50response to pheromone (GO:0019236)3.06242714
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.00011588
52regulation of regulatory T cell differentiation (GO:0045589)2.98477210
53purine-containing compound salvage (GO:0043101)2.98220462
54tryptophan catabolic process (GO:0006569)2.95744744
55indole-containing compound catabolic process (GO:0042436)2.95744744
56indolalkylamine catabolic process (GO:0046218)2.95744744
57water-soluble vitamin biosynthetic process (GO:0042364)2.95288510
58purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.94565650
59positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94221105
60positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.90890119
61mannosylation (GO:0097502)2.90374516
62positive regulation of cell cycle arrest (GO:0071158)2.89018857
63pseudouridine synthesis (GO:0001522)2.88657138
64exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.88588771
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.88143967
66regulation of B cell receptor signaling pathway (GO:0050855)2.87850368
67DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.86973948
68regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.86139215
69mast cell activation (GO:0045576)2.83076073
70regulation of cellular amine metabolic process (GO:0033238)2.78008965
71positive regulation of ligase activity (GO:0051351)2.74051865
72protein-cofactor linkage (GO:0018065)2.73970497
73negative T cell selection (GO:0043383)2.72276334
74regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.71962537
75purine deoxyribonucleotide catabolic process (GO:0009155)2.68816493
76deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.68126030
77negative regulation of calcium ion transport into cytosol (GO:0010523)2.66646866
78negative regulation of T cell apoptotic process (GO:0070233)2.66079402
79kynurenine metabolic process (GO:0070189)2.65944399
80response to interferon-beta (GO:0035456)2.64875126
81tryptophan metabolic process (GO:0006568)2.64783566
82xenobiotic catabolic process (GO:0042178)2.62946060
83DNA ligation (GO:0006266)2.61779044
84positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.61426845
85antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.61373626
86T cell migration (GO:0072678)2.59754291
87positive regulation of calcium-mediated signaling (GO:0050850)2.59230828
88Arp2/3 complex-mediated actin nucleation (GO:0034314)2.59038257
89establishment of protein localization to mitochondrial membrane (GO:0090151)2.58780713
90mast cell degranulation (GO:0043303)2.56242623
91mast cell activation involved in immune response (GO:0002279)2.56242623
92S-adenosylmethionine metabolic process (GO:0046500)2.55642897
93T cell receptor signaling pathway (GO:0050852)2.53855349
94tRNA processing (GO:0008033)2.53675685
95actin nucleation (GO:0045010)2.53352049
96positive regulation of oligodendrocyte differentiation (GO:0048714)2.52523085
97regulation of isotype switching to IgG isotypes (GO:0048302)2.52031631
98hydrogen ion transmembrane transport (GO:1902600)2.52024170
99ribosomal small subunit assembly (GO:0000028)2.51709741
100negative regulation of thymocyte apoptotic process (GO:0070244)2.51266434

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.35295946
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.11597073
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.77817746
4VDR_22108803_ChIP-Seq_LS180_Human3.77336488
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.57369190
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.24622412
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.95886002
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.76833770
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.73433306
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.66648253
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.55499910
12ZNF274_21170338_ChIP-Seq_K562_Hela2.52022909
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.45889463
14VDR_23849224_ChIP-Seq_CD4+_Human2.45142564
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42919936
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.34083539
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.25602298
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.25553366
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.19985065
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17402836
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16534198
22ELK1_19687146_ChIP-ChIP_HELA_Human2.08603370
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95719739
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89597665
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.86806856
26FOXP3_21729870_ChIP-Seq_TREG_Human1.79280513
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70864505
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70702806
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.67588183
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66435988
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.63300467
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54375617
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50085927
34IGF1R_20145208_ChIP-Seq_DFB_Human1.48703148
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.48580710
36MYB_26560356_Chip-Seq_TH2_Human1.47270208
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43217481
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42628161
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41512305
40TP53_22573176_ChIP-Seq_HFKS_Human1.39386505
41FUS_26573619_Chip-Seq_HEK293_Human1.37354267
42GATA3_26560356_Chip-Seq_TH2_Human1.37153870
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35704055
44ER_23166858_ChIP-Seq_MCF-7_Human1.34144603
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33510716
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33440906
47NANOG_19829295_ChIP-Seq_ESCs_Human1.33085996
48SOX2_19829295_ChIP-Seq_ESCs_Human1.33085996
49TAF15_26573619_Chip-Seq_HEK293_Human1.31135210
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.30444731
51P300_19829295_ChIP-Seq_ESCs_Human1.29058842
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27839339
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26145041
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.24833426
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24447494
56PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.24322149
57IRF1_19129219_ChIP-ChIP_H3396_Human1.21407380
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.20740266
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20740266
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18995949
61FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16242194
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15746679
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15178565
64EWS_26573619_Chip-Seq_HEK293_Human1.14541891
65AR_20517297_ChIP-Seq_VCAP_Human1.14417036
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13997085
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13930673
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.12720671
69GATA3_27048872_Chip-Seq_THYMUS_Human1.12220947
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10901694
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10790351
72NCOR_22424771_ChIP-Seq_293T_Human1.10708306
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10505842
74FOXH1_21741376_ChIP-Seq_EPCs_Human1.09617312
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07577377
76ELK1_22589737_ChIP-Seq_MCF10A_Human1.07455241
77BCAT_22108803_ChIP-Seq_LS180_Human1.07324112
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04894341
79SALL4_22934838_ChIP-ChIP_CD34+_Human1.04723788
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03062925
81AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01270925
82MYC_18940864_ChIP-ChIP_HL60_Human1.00762555
83TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00140315
84PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99844450
85GBX2_23144817_ChIP-Seq_PC3_Human0.99425206
86YY1_21170310_ChIP-Seq_MESCs_Mouse0.99213528
87CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99046132
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97600023
89CBP_20019798_ChIP-Seq_JUKART_Human0.95232834
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95232834
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94902933
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92483589
93POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92218431
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92209413
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91869691
96ERG_20517297_ChIP-Seq_VCAP_Human0.91701354
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91294546
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91041875
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90408109
100RUNX_20019798_ChIP-Seq_JUKART_Human0.88459118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.29633123
2MP0004147_increased_porphyrin_level3.32266436
3MP0002138_abnormal_hepatobiliary_system3.20680903
4MP0001835_abnormal_antigen_presentation3.11973450
5MP0009785_altered_susceptibility_to2.76161638
6MP0005645_abnormal_hypothalamus_physiol2.58647069
7MP0005075_abnormal_melanosome_morpholog2.22279979
8MP0001800_abnormal_humoral_immune2.18887511
9MP0002102_abnormal_ear_morphology2.17496255
10MP0002166_altered_tumor_susceptibility2.11523250
11MP0008995_early_reproductive_senescence2.10969722
12MP0009333_abnormal_splenocyte_physiolog2.10399101
13MP0003786_premature_aging2.00962997
14MP0003806_abnormal_nucleotide_metabolis1.95530603
15MP0000372_irregular_coat_pigmentation1.94375416
16MP0002006_tumorigenesis1.91001947
17MP0005646_abnormal_pituitary_gland1.87958564
18MP0003724_increased_susceptibility_to1.87125948
19MP0002148_abnormal_hypersensitivity_rea1.86031171
20MP0005000_abnormal_immune_tolerance1.81894192
21MP0005387_immune_system_phenotype1.77826105
22MP0001790_abnormal_immune_system1.77826105
23MP0008872_abnormal_physiological_respon1.75365847
24MP0008877_abnormal_DNA_methylation1.67217724
25MP0002723_abnormal_immune_serum1.64957319
26MP0003880_abnormal_central_pattern1.64635494
27MP0003763_abnormal_thymus_physiology1.62233798
28MP0003011_delayed_dark_adaptation1.60789388
29MP0003646_muscle_fatigue1.58795715
30MP0002736_abnormal_nociception_after1.58764467
31MP0001968_abnormal_touch/_nociception1.55770291
32MP0003866_abnormal_defecation1.54073172
33MP0003045_fibrosis1.54056684
34MP0002095_abnormal_skin_pigmentation1.49258994
35MP0004145_abnormal_muscle_electrophysio1.46938314
36MP0005379_endocrine/exocrine_gland_phen1.45724895
37MP0006072_abnormal_retinal_apoptosis1.44461387
38MP0002420_abnormal_adaptive_immunity1.44094990
39MP0006036_abnormal_mitochondrial_physio1.43988500
40MP0002452_abnormal_antigen_presenting1.42041862
41MP0003252_abnormal_bile_duct1.41992999
42MP0003195_calcinosis1.40218264
43MP0001819_abnormal_immune_cell1.39532540
44MP0008875_abnormal_xenobiotic_pharmacok1.38474500
45MP0005551_abnormal_eye_electrophysiolog1.37821090
46MP0002163_abnormal_gland_morphology1.34568391
47MP0003878_abnormal_ear_physiology1.33209496
48MP0005377_hearing/vestibular/ear_phenot1.33209496
49MP0005025_abnormal_response_to1.30241651
50MP0004043_abnormal_pH_regulation1.26884920
51MP0000685_abnormal_immune_system1.26529147
52MP0004885_abnormal_endolymph1.26156158
53MP0002160_abnormal_reproductive_system1.25689478
54MP0002837_dystrophic_cardiac_calcinosis1.21690561
55MP0001905_abnormal_dopamine_level1.19962336
56MP0005389_reproductive_system_phenotype1.18883318
57MP0005085_abnormal_gallbladder_physiolo1.18487999
58MP0001764_abnormal_homeostasis1.16385278
59MP0002876_abnormal_thyroid_physiology1.16228607
60MP0004142_abnormal_muscle_tone1.15171754
61MP0003186_abnormal_redox_activity1.15011558
62MP0000716_abnormal_immune_system1.11800074
63MP0009764_decreased_sensitivity_to1.11156235
64MP0001986_abnormal_taste_sensitivity1.10870096
65MP0005670_abnormal_white_adipose1.10264144
66MP0001919_abnormal_reproductive_system1.10232282
67MP0002398_abnormal_bone_marrow1.09382901
68MP0002277_abnormal_respiratory_mucosa1.07986783
69MP0005360_urolithiasis1.07062871
70MP0005253_abnormal_eye_physiology1.06684510
71MP0000689_abnormal_spleen_morphology1.06455883
72MP0001984_abnormal_olfaction1.06019273
73MP0001845_abnormal_inflammatory_respons1.02972277
74MP0005636_abnormal_mineral_homeostasis1.01207719
75MP0002405_respiratory_system_inflammati0.98568072
76MP0001529_abnormal_vocalization0.97519884
77MP0006082_CNS_inflammation0.95343644
78MP0002638_abnormal_pupillary_reflex0.94788728
79MP0008058_abnormal_DNA_repair0.91968935
80MP0002396_abnormal_hematopoietic_system0.90737669
81MP0002722_abnormal_immune_system0.90684085
82MP0000647_abnormal_sebaceous_gland0.89733523
83MP0002938_white_spotting0.86748922
84MP0009745_abnormal_behavioral_response0.86102182
85MP0000703_abnormal_thymus_morphology0.85811466
86MP0002429_abnormal_blood_cell0.84463356
87MP0008469_abnormal_protein_level0.83699632
88MP0005084_abnormal_gallbladder_morpholo0.83397805
89MP0001440_abnormal_grooming_behavior0.83170162
90MP0006035_abnormal_mitochondrial_morpho0.78768880
91MP0002419_abnormal_innate_immunity0.75287945
92MP0006054_spinal_hemorrhage0.74812783
93MP0006276_abnormal_autonomic_nervous0.74639197
94MP0001873_stomach_inflammation0.74577945
95MP0010155_abnormal_intestine_physiology0.74546495
96MP0001119_abnormal_female_reproductive0.73206861
97MP0010386_abnormal_urinary_bladder0.71216408
98MP0002735_abnormal_chemical_nociception0.70767840
99MP0009643_abnormal_urine_homeostasis0.70060489
100MP0003436_decreased_susceptibility_to0.69556791

Predicted human phenotypes

RankGene SetZ-score
1Decreased electroretinogram (ERG) amplitude (HP:0000654)4.17565273
2Mitochondrial inheritance (HP:0001427)3.68743804
3Hyperalaninemia (HP:0003348)3.64865209
4Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.64865209
5Abnormality of alanine metabolism (HP:0010916)3.64865209
6Acute necrotizing encephalopathy (HP:0006965)3.62759544
7Increased CSF lactate (HP:0002490)3.48235506
8Increased hepatocellular lipid droplets (HP:0006565)3.32190524
9IgG deficiency (HP:0004315)3.31590190
10Congenital stationary night blindness (HP:0007642)3.29519561
11Abnormality of T cell number (HP:0011839)3.29168188
12Hepatocellular necrosis (HP:0001404)3.27780055
13Aplastic anemia (HP:0001915)3.27054540
143-Methylglutaconic aciduria (HP:0003535)3.22256631
15Constricted visual fields (HP:0001133)3.21171028
16Generalized aminoaciduria (HP:0002909)3.19305123
17Abnormal mitochondria in muscle tissue (HP:0008316)3.18174237
18Progressive macrocephaly (HP:0004481)3.17405545
19Autoimmune hemolytic anemia (HP:0001890)3.10662794
20Increased IgM level (HP:0003496)3.07664234
21Thyroiditis (HP:0100646)3.06630201
22T lymphocytopenia (HP:0005403)3.06377331
23Severe combined immunodeficiency (HP:0004430)3.03681791
24Acute encephalopathy (HP:0006846)3.03354568
25Lipid accumulation in hepatocytes (HP:0006561)3.01425346
26Hypoproteinemia (HP:0003075)2.95718789
27Elevated erythrocyte sedimentation rate (HP:0003565)2.94956241
28Hepatic necrosis (HP:0002605)2.94915515
29Renal Fanconi syndrome (HP:0001994)2.89126156
30Abnormality of B cell number (HP:0010975)2.87810634
31Abolished electroretinogram (ERG) (HP:0000550)2.83897578
32Increased serum lactate (HP:0002151)2.75239069
33Attenuation of retinal blood vessels (HP:0007843)2.73140120
34Lactic acidosis (HP:0003128)2.61951877
35Abnormality of eosinophils (HP:0001879)2.56884247
36Increased intramyocellular lipid droplets (HP:0012240)2.51284723
37Abnormality of the prostate (HP:0008775)2.42978890
38Exertional dyspnea (HP:0002875)2.42028126
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.41467400
40Cerebral edema (HP:0002181)2.39889374
41Pancreatic cysts (HP:0001737)2.39255125
42Methylmalonic acidemia (HP:0002912)2.35694861
43Optic disc pallor (HP:0000543)2.34135493
44Abnormality of T cells (HP:0002843)2.32977575
45Type I transferrin isoform profile (HP:0003642)2.32707545
46Combined immunodeficiency (HP:0005387)2.27045142
47Pendular nystagmus (HP:0012043)2.26446253
48Autoimmune thrombocytopenia (HP:0001973)2.20303694
49Abnormality of urine glucose concentration (HP:0011016)2.20123719
50Glycosuria (HP:0003076)2.20123719
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18345300
52Decreased activity of mitochondrial respiratory chain (HP:0008972)2.17423894
53Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.17423894
54Congenital, generalized hypertrichosis (HP:0004540)2.16293460
55Pancytopenia (HP:0001876)2.14775403
56Abnormality of serum amino acid levels (HP:0003112)2.12167734
57Eosinophilia (HP:0001880)2.11253045
58Stomach cancer (HP:0012126)2.09920281
59Stomatitis (HP:0010280)2.09516473
60Methylmalonic aciduria (HP:0012120)2.04335844
61Increased muscle lipid content (HP:0009058)1.99215287
62Oral leukoplakia (HP:0002745)1.98406197
63B lymphocytopenia (HP:0010976)1.97426830
64Abnormality of the renal cortex (HP:0011035)1.93468000
65Anorexia (HP:0002039)1.93105784
66Respiratory failure (HP:0002878)1.90557200
67IgM deficiency (HP:0002850)1.90289538
68Abnormal drinking behavior (HP:0030082)1.90284439
69Polydipsia (HP:0001959)1.90284439
70Hyperphosphaturia (HP:0003109)1.89015643
71Lethargy (HP:0001254)1.88619703
72Pulmonary embolism (HP:0002204)1.85754583
73Abnormal rod and cone electroretinograms (HP:0008323)1.84746929
74Abnormality of the labia minora (HP:0012880)1.84679447
75Pancreatic fibrosis (HP:0100732)1.84403424
76Abnormal delayed hypersensitivity skin test (HP:0002963)1.83981650
77Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83155312
78Dicarboxylic aciduria (HP:0003215)1.83155312
79Abnormal albumin level (HP:0012116)1.82785186
80Hypoalbuminemia (HP:0003073)1.82785186
81Granulocytopenia (HP:0001913)1.82093484
82Chronic otitis media (HP:0000389)1.81320802
83Type 2 muscle fiber atrophy (HP:0003554)1.80938326
84Abnormality of midbrain morphology (HP:0002418)1.80469064
85Molar tooth sign on MRI (HP:0002419)1.80469064
86Chronic sinusitis (HP:0011109)1.77644524
87Colon cancer (HP:0003003)1.77528135
88Abnormality of the ileum (HP:0001549)1.77061754
89Severe visual impairment (HP:0001141)1.76249832
90Exercise intolerance (HP:0003546)1.75457633
91Abnormality of renal resorption (HP:0011038)1.74752145
92Hypokalemic alkalosis (HP:0001949)1.74598403
93Chronic diarrhea (HP:0002028)1.74344561
94Metabolic alkalosis (HP:0200114)1.72669729
95Polyuria (HP:0000103)1.72225018
96True hermaphroditism (HP:0010459)1.71679048
97Abnormal spermatogenesis (HP:0008669)1.69237015
98Meckel diverticulum (HP:0002245)1.68359919
99Absent rod-and cone-mediated responses on ERG (HP:0007688)1.68260943
100Hemoptysis (HP:0002105)1.67963712

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.23016951
2TXK3.20685549
3KDR2.82907742
4MAP3K122.74512819
5MAP4K22.48561187
6VRK22.32767647
7BUB12.32132474
8PINK12.24512207
9ZAK2.20520454
10NUAK12.17590034
11FRK2.09433399
12EIF2AK12.04088791
13ADRBK22.03772457
14EIF2AK31.97050516
15BCKDK1.93933373
16TLK11.93701203
17TSSK61.80158833
18PASK1.76786568
19VRK11.69706481
20CDK191.57537787
21TESK21.56399339
22PIK3CG1.55372209
23WNK31.52891511
24CAMKK21.47674963
25ITK1.45173664
26STK161.37444773
27TRIM281.34803952
28CCNB11.30126125
29TEC1.29990883
30JAK31.28955346
31GRK11.26491792
32TAOK31.17832405
33PLK31.13179216
34KIT1.11846538
35SCYL21.10914625
36PLK21.10660851
37MAP4K11.09594681
38MYLK1.08593192
39NEK11.05631857
40INSRR1.03558758
41BCR1.03210093
42SRPK11.00185363
43ERBB30.97504458
44SYK0.97360389
45WNK40.96414333
46FES0.94378317
47OXSR10.89283502
48PRKCQ0.86366593
49LCK0.85369275
50OBSCN0.82772847
51CAMKK10.82575714
52PHKG20.80210693
53PHKG10.80210693
54PDK20.77953267
55IKBKB0.76124690
56MAP3K30.76031563
57SIK30.75475424
58TIE10.74368456
59DAPK10.74267656
60LYN0.69082994
61BMPR20.68760939
62PLK40.66640260
63BTK0.64426646
64ADRBK10.63119684
65IKBKE0.60851314
66BRSK20.60640080
67PIK3CA0.60016103
68MATK0.58801461
69GRK60.57997165
70PBK0.57913465
71DYRK20.56120432
72IGF1R0.56020787
73CSF1R0.55890867
74CSNK1G20.54431763
75CSNK1G30.52600575
76NME10.50389997
77RPS6KA50.48965433
78CSNK1G10.47897245
79TAF10.45803987
80EGFR0.42380536
81RIPK40.41339395
82FGR0.41264028
83PRKCA0.39367056
84TNIK0.39253030
85DAPK30.38750751
86PRKCE0.38148207
87MAPK130.37479314
88ILK0.37419016
89STK390.37260901
90GRK70.36616042
91LIMK10.36525379
92ACVR1B0.36484768
93PRKACA0.36412709
94BMPR1B0.35153618
95CAMK2A0.34695938
96TESK10.33568888
97CSNK2A10.33356976
98IRAK40.33003346
99GRK50.32474110
100CSNK1A1L0.32084945

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.81008789
2Primary immunodeficiency_Homo sapiens_hsa053403.22239300
3Oxidative phosphorylation_Homo sapiens_hsa001903.18404690
4Asthma_Homo sapiens_hsa053103.15793214
5Allograft rejection_Homo sapiens_hsa053302.98492656
6Autoimmune thyroid disease_Homo sapiens_hsa053202.98331509
7Graft-versus-host disease_Homo sapiens_hsa053322.70860155
8Parkinsons disease_Homo sapiens_hsa050122.51398976
9Type I diabetes mellitus_Homo sapiens_hsa049402.50278306
10Protein export_Homo sapiens_hsa030602.22788936
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.15319424
12Antigen processing and presentation_Homo sapiens_hsa046122.14172194
13Rheumatoid arthritis_Homo sapiens_hsa053231.94585316
14One carbon pool by folate_Homo sapiens_hsa006701.83721571
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76289962
16RNA polymerase_Homo sapiens_hsa030201.76038698
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74762959
18Collecting duct acid secretion_Homo sapiens_hsa049661.69171928
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67830508
20Ribosome_Homo sapiens_hsa030101.61030944
21Hematopoietic cell lineage_Homo sapiens_hsa046401.57430299
22Nitrogen metabolism_Homo sapiens_hsa009101.54495974
23Alzheimers disease_Homo sapiens_hsa050101.51833510
24Huntingtons disease_Homo sapiens_hsa050161.40280398
25Peroxisome_Homo sapiens_hsa041461.39871981
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32945038
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30783723
28RNA degradation_Homo sapiens_hsa030181.29844529
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21672886
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.19199756
31Phototransduction_Homo sapiens_hsa047441.18341478
32Viral myocarditis_Homo sapiens_hsa054161.13570343
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13183268
34Caffeine metabolism_Homo sapiens_hsa002321.12768857
35Homologous recombination_Homo sapiens_hsa034401.09505453
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.08677394
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06638057
38DNA replication_Homo sapiens_hsa030301.03241690
39Systemic lupus erythematosus_Homo sapiens_hsa053221.02836706
40Mismatch repair_Homo sapiens_hsa034300.98399969
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93670403
42Staphylococcus aureus infection_Homo sapiens_hsa051500.90954550
43Retinol metabolism_Homo sapiens_hsa008300.90871216
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90159412
45Fanconi anemia pathway_Homo sapiens_hsa034600.89792757
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88963788
47Basal transcription factors_Homo sapiens_hsa030220.88489259
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88443766
49Propanoate metabolism_Homo sapiens_hsa006400.85288122
50Cardiac muscle contraction_Homo sapiens_hsa042600.84205185
51Nucleotide excision repair_Homo sapiens_hsa034200.82209659
52Chemical carcinogenesis_Homo sapiens_hsa052040.81374644
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79159669
54T cell receptor signaling pathway_Homo sapiens_hsa046600.76700499
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75098654
56Base excision repair_Homo sapiens_hsa034100.75003858
57RNA transport_Homo sapiens_hsa030130.74599695
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73352960
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72951884
60Purine metabolism_Homo sapiens_hsa002300.72880150
61Tryptophan metabolism_Homo sapiens_hsa003800.72653553
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72457996
63Linoleic acid metabolism_Homo sapiens_hsa005910.71186240
64Measles_Homo sapiens_hsa051620.70266999
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.68104945
66Regulation of autophagy_Homo sapiens_hsa041400.66237418
67Butanoate metabolism_Homo sapiens_hsa006500.65483403
68Pyrimidine metabolism_Homo sapiens_hsa002400.64230520
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62517744
70Glutathione metabolism_Homo sapiens_hsa004800.62457293
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62390343
72Leishmaniasis_Homo sapiens_hsa051400.58941464
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.58538764
74Spliceosome_Homo sapiens_hsa030400.58298521
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55438092
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53991507
77Legionellosis_Homo sapiens_hsa051340.53920066
78Olfactory transduction_Homo sapiens_hsa047400.52350488
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.51150023
80Pyruvate metabolism_Homo sapiens_hsa006200.50561579
81Metabolic pathways_Homo sapiens_hsa011000.47861959
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47843429
83Arachidonic acid metabolism_Homo sapiens_hsa005900.44581798
84Fatty acid elongation_Homo sapiens_hsa000620.43524697
85Herpes simplex infection_Homo sapiens_hsa051680.42874331
86Epstein-Barr virus infection_Homo sapiens_hsa051690.40964317
87Morphine addiction_Homo sapiens_hsa050320.40879902
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40684860
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36991623
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36045659
91Non-homologous end-joining_Homo sapiens_hsa034500.34240259
92Nicotine addiction_Homo sapiens_hsa050330.34091347
93Arginine biosynthesis_Homo sapiens_hsa002200.31070811
94Taste transduction_Homo sapiens_hsa047420.30701111
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30457583
96Sulfur metabolism_Homo sapiens_hsa009200.29748179
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28906028
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.25202833
99GABAergic synapse_Homo sapiens_hsa047270.24900805
100Steroid biosynthesis_Homo sapiens_hsa001000.22929773

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