

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 5.44638136 |
| 2 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 5.44638136 |
| 3 | DNA deamination (GO:0045006) | 5.25059192 |
| 4 | cytidine metabolic process (GO:0046087) | 4.52041325 |
| 5 | cytidine catabolic process (GO:0006216) | 4.52041325 |
| 6 | cytidine deamination (GO:0009972) | 4.52041325 |
| 7 | proteasome assembly (GO:0043248) | 4.48563676 |
| 8 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.34600838 |
| 9 | adenosine metabolic process (GO:0046085) | 4.25617893 |
| 10 | respiratory chain complex IV assembly (GO:0008535) | 4.10679000 |
| 11 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.94440592 |
| 12 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.84506950 |
| 13 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.79704943 |
| 14 | protein complex biogenesis (GO:0070271) | 3.79235664 |
| 15 | platelet dense granule organization (GO:0060155) | 3.72420123 |
| 16 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.70568947 |
| 17 | rRNA modification (GO:0000154) | 3.69450334 |
| 18 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.66834779 |
| 19 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.66834779 |
| 20 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.66182832 |
| 21 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.66182832 |
| 22 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.66182832 |
| 23 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.62363896 |
| 24 | purine nucleotide salvage (GO:0032261) | 3.61024206 |
| 25 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.56907667 |
| 26 | cullin deneddylation (GO:0010388) | 3.56590033 |
| 27 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.51203453 |
| 28 | NADH dehydrogenase complex assembly (GO:0010257) | 3.51203453 |
| 29 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.51203453 |
| 30 | protein deneddylation (GO:0000338) | 3.50022248 |
| 31 | ATP synthesis coupled proton transport (GO:0015986) | 3.45777441 |
| 32 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.45777441 |
| 33 | negative regulation of ligase activity (GO:0051352) | 3.45221087 |
| 34 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.45221087 |
| 35 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.42840095 |
| 36 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.42840095 |
| 37 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.42251974 |
| 38 | sequestering of actin monomers (GO:0042989) | 3.40913784 |
| 39 | cytochrome complex assembly (GO:0017004) | 3.39573869 |
| 40 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.38759476 |
| 41 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.38746268 |
| 42 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.33305115 |
| 43 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.32023584 |
| 44 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.21026206 |
| 45 | rRNA methylation (GO:0031167) | 3.15905257 |
| 46 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.11849359 |
| 47 | respiratory electron transport chain (GO:0022904) | 3.08268155 |
| 48 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.07677458 |
| 49 | electron transport chain (GO:0022900) | 3.06589498 |
| 50 | response to pheromone (GO:0019236) | 3.06242714 |
| 51 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.00011588 |
| 52 | regulation of regulatory T cell differentiation (GO:0045589) | 2.98477210 |
| 53 | purine-containing compound salvage (GO:0043101) | 2.98220462 |
| 54 | tryptophan catabolic process (GO:0006569) | 2.95744744 |
| 55 | indole-containing compound catabolic process (GO:0042436) | 2.95744744 |
| 56 | indolalkylamine catabolic process (GO:0046218) | 2.95744744 |
| 57 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.95288510 |
| 58 | purine deoxyribonucleoside triphosphate metabolic process (GO:0009215) | 2.94565650 |
| 59 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.94221105 |
| 60 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 2.90890119 |
| 61 | mannosylation (GO:0097502) | 2.90374516 |
| 62 | positive regulation of cell cycle arrest (GO:0071158) | 2.89018857 |
| 63 | pseudouridine synthesis (GO:0001522) | 2.88657138 |
| 64 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.88588771 |
| 65 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 2.88143967 |
| 66 | regulation of B cell receptor signaling pathway (GO:0050855) | 2.87850368 |
| 67 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.86973948 |
| 68 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 2.86139215 |
| 69 | mast cell activation (GO:0045576) | 2.83076073 |
| 70 | regulation of cellular amine metabolic process (GO:0033238) | 2.78008965 |
| 71 | positive regulation of ligase activity (GO:0051351) | 2.74051865 |
| 72 | protein-cofactor linkage (GO:0018065) | 2.73970497 |
| 73 | negative T cell selection (GO:0043383) | 2.72276334 |
| 74 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 2.71962537 |
| 75 | purine deoxyribonucleotide catabolic process (GO:0009155) | 2.68816493 |
| 76 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.68126030 |
| 77 | negative regulation of calcium ion transport into cytosol (GO:0010523) | 2.66646866 |
| 78 | negative regulation of T cell apoptotic process (GO:0070233) | 2.66079402 |
| 79 | kynurenine metabolic process (GO:0070189) | 2.65944399 |
| 80 | response to interferon-beta (GO:0035456) | 2.64875126 |
| 81 | tryptophan metabolic process (GO:0006568) | 2.64783566 |
| 82 | xenobiotic catabolic process (GO:0042178) | 2.62946060 |
| 83 | DNA ligation (GO:0006266) | 2.61779044 |
| 84 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 2.61426845 |
| 85 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.61373626 |
| 86 | T cell migration (GO:0072678) | 2.59754291 |
| 87 | positive regulation of calcium-mediated signaling (GO:0050850) | 2.59230828 |
| 88 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.59038257 |
| 89 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.58780713 |
| 90 | mast cell degranulation (GO:0043303) | 2.56242623 |
| 91 | mast cell activation involved in immune response (GO:0002279) | 2.56242623 |
| 92 | S-adenosylmethionine metabolic process (GO:0046500) | 2.55642897 |
| 93 | T cell receptor signaling pathway (GO:0050852) | 2.53855349 |
| 94 | tRNA processing (GO:0008033) | 2.53675685 |
| 95 | actin nucleation (GO:0045010) | 2.53352049 |
| 96 | positive regulation of oligodendrocyte differentiation (GO:0048714) | 2.52523085 |
| 97 | regulation of isotype switching to IgG isotypes (GO:0048302) | 2.52031631 |
| 98 | hydrogen ion transmembrane transport (GO:1902600) | 2.52024170 |
| 99 | ribosomal small subunit assembly (GO:0000028) | 2.51709741 |
| 100 | negative regulation of thymocyte apoptotic process (GO:0070244) | 2.51266434 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.35295946 |
| 2 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.11597073 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.77817746 |
| 4 | VDR_22108803_ChIP-Seq_LS180_Human | 3.77336488 |
| 5 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.57369190 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.24622412 |
| 7 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.95886002 |
| 8 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.76833770 |
| 9 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.73433306 |
| 10 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.66648253 |
| 11 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.55499910 |
| 12 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.52022909 |
| 13 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.45889463 |
| 14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.45142564 |
| 15 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.42919936 |
| 16 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.34083539 |
| 17 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.25602298 |
| 18 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.25553366 |
| 19 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.19985065 |
| 20 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.17402836 |
| 21 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.16534198 |
| 22 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.08603370 |
| 23 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.95719739 |
| 24 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.89597665 |
| 25 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.86806856 |
| 26 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.79280513 |
| 27 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.70864505 |
| 28 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.70702806 |
| 29 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.67588183 |
| 30 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.66435988 |
| 31 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.63300467 |
| 32 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.54375617 |
| 33 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.50085927 |
| 34 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.48703148 |
| 35 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.48580710 |
| 36 | MYB_26560356_Chip-Seq_TH2_Human | 1.47270208 |
| 37 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.43217481 |
| 38 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.42628161 |
| 39 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.41512305 |
| 40 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.39386505 |
| 41 | FUS_26573619_Chip-Seq_HEK293_Human | 1.37354267 |
| 42 | GATA3_26560356_Chip-Seq_TH2_Human | 1.37153870 |
| 43 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.35704055 |
| 44 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.34144603 |
| 45 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.33510716 |
| 46 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.33440906 |
| 47 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.33085996 |
| 48 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.33085996 |
| 49 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.31135210 |
| 50 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.30444731 |
| 51 | P300_19829295_ChIP-Seq_ESCs_Human | 1.29058842 |
| 52 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.27839339 |
| 53 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.26145041 |
| 54 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.24833426 |
| 55 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.24447494 |
| 56 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.24322149 |
| 57 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.21407380 |
| 58 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.20740266 |
| 59 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.20740266 |
| 60 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.18995949 |
| 61 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.16242194 |
| 62 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.15746679 |
| 63 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.15178565 |
| 64 | EWS_26573619_Chip-Seq_HEK293_Human | 1.14541891 |
| 65 | AR_20517297_ChIP-Seq_VCAP_Human | 1.14417036 |
| 66 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.13997085 |
| 67 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.13930673 |
| 68 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.12720671 |
| 69 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.12220947 |
| 70 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.10901694 |
| 71 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.10790351 |
| 72 | NCOR_22424771_ChIP-Seq_293T_Human | 1.10708306 |
| 73 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.10505842 |
| 74 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 1.09617312 |
| 75 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.07577377 |
| 76 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.07455241 |
| 77 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.07324112 |
| 78 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.04894341 |
| 79 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 1.04723788 |
| 80 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.03062925 |
| 81 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.01270925 |
| 82 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.00762555 |
| 83 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.00140315 |
| 84 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.99844450 |
| 85 | GBX2_23144817_ChIP-Seq_PC3_Human | 0.99425206 |
| 86 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.99213528 |
| 87 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.99046132 |
| 88 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.97600023 |
| 89 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.95232834 |
| 90 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.95232834 |
| 91 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.94902933 |
| 92 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.92483589 |
| 93 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.92218431 |
| 94 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.92209413 |
| 95 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.91869691 |
| 96 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.91701354 |
| 97 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.91294546 |
| 98 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.91041875 |
| 99 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.90408109 |
| 100 | RUNX_20019798_ChIP-Seq_JUKART_Human | 0.88459118 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005671_abnormal_response_to | 4.29633123 |
| 2 | MP0004147_increased_porphyrin_level | 3.32266436 |
| 3 | MP0002138_abnormal_hepatobiliary_system | 3.20680903 |
| 4 | MP0001835_abnormal_antigen_presentation | 3.11973450 |
| 5 | MP0009785_altered_susceptibility_to | 2.76161638 |
| 6 | MP0005645_abnormal_hypothalamus_physiol | 2.58647069 |
| 7 | MP0005075_abnormal_melanosome_morpholog | 2.22279979 |
| 8 | MP0001800_abnormal_humoral_immune | 2.18887511 |
| 9 | MP0002102_abnormal_ear_morphology | 2.17496255 |
| 10 | MP0002166_altered_tumor_susceptibility | 2.11523250 |
| 11 | MP0008995_early_reproductive_senescence | 2.10969722 |
| 12 | MP0009333_abnormal_splenocyte_physiolog | 2.10399101 |
| 13 | MP0003786_premature_aging | 2.00962997 |
| 14 | MP0003806_abnormal_nucleotide_metabolis | 1.95530603 |
| 15 | MP0000372_irregular_coat_pigmentation | 1.94375416 |
| 16 | MP0002006_tumorigenesis | 1.91001947 |
| 17 | MP0005646_abnormal_pituitary_gland | 1.87958564 |
| 18 | MP0003724_increased_susceptibility_to | 1.87125948 |
| 19 | MP0002148_abnormal_hypersensitivity_rea | 1.86031171 |
| 20 | MP0005000_abnormal_immune_tolerance | 1.81894192 |
| 21 | MP0005387_immune_system_phenotype | 1.77826105 |
| 22 | MP0001790_abnormal_immune_system | 1.77826105 |
| 23 | MP0008872_abnormal_physiological_respon | 1.75365847 |
| 24 | MP0008877_abnormal_DNA_methylation | 1.67217724 |
| 25 | MP0002723_abnormal_immune_serum | 1.64957319 |
| 26 | MP0003880_abnormal_central_pattern | 1.64635494 |
| 27 | MP0003763_abnormal_thymus_physiology | 1.62233798 |
| 28 | MP0003011_delayed_dark_adaptation | 1.60789388 |
| 29 | MP0003646_muscle_fatigue | 1.58795715 |
| 30 | MP0002736_abnormal_nociception_after | 1.58764467 |
| 31 | MP0001968_abnormal_touch/_nociception | 1.55770291 |
| 32 | MP0003866_abnormal_defecation | 1.54073172 |
| 33 | MP0003045_fibrosis | 1.54056684 |
| 34 | MP0002095_abnormal_skin_pigmentation | 1.49258994 |
| 35 | MP0004145_abnormal_muscle_electrophysio | 1.46938314 |
| 36 | MP0005379_endocrine/exocrine_gland_phen | 1.45724895 |
| 37 | MP0006072_abnormal_retinal_apoptosis | 1.44461387 |
| 38 | MP0002420_abnormal_adaptive_immunity | 1.44094990 |
| 39 | MP0006036_abnormal_mitochondrial_physio | 1.43988500 |
| 40 | MP0002452_abnormal_antigen_presenting | 1.42041862 |
| 41 | MP0003252_abnormal_bile_duct | 1.41992999 |
| 42 | MP0003195_calcinosis | 1.40218264 |
| 43 | MP0001819_abnormal_immune_cell | 1.39532540 |
| 44 | MP0008875_abnormal_xenobiotic_pharmacok | 1.38474500 |
| 45 | MP0005551_abnormal_eye_electrophysiolog | 1.37821090 |
| 46 | MP0002163_abnormal_gland_morphology | 1.34568391 |
| 47 | MP0003878_abnormal_ear_physiology | 1.33209496 |
| 48 | MP0005377_hearing/vestibular/ear_phenot | 1.33209496 |
| 49 | MP0005025_abnormal_response_to | 1.30241651 |
| 50 | MP0004043_abnormal_pH_regulation | 1.26884920 |
| 51 | MP0000685_abnormal_immune_system | 1.26529147 |
| 52 | MP0004885_abnormal_endolymph | 1.26156158 |
| 53 | MP0002160_abnormal_reproductive_system | 1.25689478 |
| 54 | MP0002837_dystrophic_cardiac_calcinosis | 1.21690561 |
| 55 | MP0001905_abnormal_dopamine_level | 1.19962336 |
| 56 | MP0005389_reproductive_system_phenotype | 1.18883318 |
| 57 | MP0005085_abnormal_gallbladder_physiolo | 1.18487999 |
| 58 | MP0001764_abnormal_homeostasis | 1.16385278 |
| 59 | MP0002876_abnormal_thyroid_physiology | 1.16228607 |
| 60 | MP0004142_abnormal_muscle_tone | 1.15171754 |
| 61 | MP0003186_abnormal_redox_activity | 1.15011558 |
| 62 | MP0000716_abnormal_immune_system | 1.11800074 |
| 63 | MP0009764_decreased_sensitivity_to | 1.11156235 |
| 64 | MP0001986_abnormal_taste_sensitivity | 1.10870096 |
| 65 | MP0005670_abnormal_white_adipose | 1.10264144 |
| 66 | MP0001919_abnormal_reproductive_system | 1.10232282 |
| 67 | MP0002398_abnormal_bone_marrow | 1.09382901 |
| 68 | MP0002277_abnormal_respiratory_mucosa | 1.07986783 |
| 69 | MP0005360_urolithiasis | 1.07062871 |
| 70 | MP0005253_abnormal_eye_physiology | 1.06684510 |
| 71 | MP0000689_abnormal_spleen_morphology | 1.06455883 |
| 72 | MP0001984_abnormal_olfaction | 1.06019273 |
| 73 | MP0001845_abnormal_inflammatory_respons | 1.02972277 |
| 74 | MP0005636_abnormal_mineral_homeostasis | 1.01207719 |
| 75 | MP0002405_respiratory_system_inflammati | 0.98568072 |
| 76 | MP0001529_abnormal_vocalization | 0.97519884 |
| 77 | MP0006082_CNS_inflammation | 0.95343644 |
| 78 | MP0002638_abnormal_pupillary_reflex | 0.94788728 |
| 79 | MP0008058_abnormal_DNA_repair | 0.91968935 |
| 80 | MP0002396_abnormal_hematopoietic_system | 0.90737669 |
| 81 | MP0002722_abnormal_immune_system | 0.90684085 |
| 82 | MP0000647_abnormal_sebaceous_gland | 0.89733523 |
| 83 | MP0002938_white_spotting | 0.86748922 |
| 84 | MP0009745_abnormal_behavioral_response | 0.86102182 |
| 85 | MP0000703_abnormal_thymus_morphology | 0.85811466 |
| 86 | MP0002429_abnormal_blood_cell | 0.84463356 |
| 87 | MP0008469_abnormal_protein_level | 0.83699632 |
| 88 | MP0005084_abnormal_gallbladder_morpholo | 0.83397805 |
| 89 | MP0001440_abnormal_grooming_behavior | 0.83170162 |
| 90 | MP0006035_abnormal_mitochondrial_morpho | 0.78768880 |
| 91 | MP0002419_abnormal_innate_immunity | 0.75287945 |
| 92 | MP0006054_spinal_hemorrhage | 0.74812783 |
| 93 | MP0006276_abnormal_autonomic_nervous | 0.74639197 |
| 94 | MP0001873_stomach_inflammation | 0.74577945 |
| 95 | MP0010155_abnormal_intestine_physiology | 0.74546495 |
| 96 | MP0001119_abnormal_female_reproductive | 0.73206861 |
| 97 | MP0010386_abnormal_urinary_bladder | 0.71216408 |
| 98 | MP0002735_abnormal_chemical_nociception | 0.70767840 |
| 99 | MP0009643_abnormal_urine_homeostasis | 0.70060489 |
| 100 | MP0003436_decreased_susceptibility_to | 0.69556791 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 4.17565273 |
| 2 | Mitochondrial inheritance (HP:0001427) | 3.68743804 |
| 3 | Hyperalaninemia (HP:0003348) | 3.64865209 |
| 4 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.64865209 |
| 5 | Abnormality of alanine metabolism (HP:0010916) | 3.64865209 |
| 6 | Acute necrotizing encephalopathy (HP:0006965) | 3.62759544 |
| 7 | Increased CSF lactate (HP:0002490) | 3.48235506 |
| 8 | Increased hepatocellular lipid droplets (HP:0006565) | 3.32190524 |
| 9 | IgG deficiency (HP:0004315) | 3.31590190 |
| 10 | Congenital stationary night blindness (HP:0007642) | 3.29519561 |
| 11 | Abnormality of T cell number (HP:0011839) | 3.29168188 |
| 12 | Hepatocellular necrosis (HP:0001404) | 3.27780055 |
| 13 | Aplastic anemia (HP:0001915) | 3.27054540 |
| 14 | 3-Methylglutaconic aciduria (HP:0003535) | 3.22256631 |
| 15 | Constricted visual fields (HP:0001133) | 3.21171028 |
| 16 | Generalized aminoaciduria (HP:0002909) | 3.19305123 |
| 17 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.18174237 |
| 18 | Progressive macrocephaly (HP:0004481) | 3.17405545 |
| 19 | Autoimmune hemolytic anemia (HP:0001890) | 3.10662794 |
| 20 | Increased IgM level (HP:0003496) | 3.07664234 |
| 21 | Thyroiditis (HP:0100646) | 3.06630201 |
| 22 | T lymphocytopenia (HP:0005403) | 3.06377331 |
| 23 | Severe combined immunodeficiency (HP:0004430) | 3.03681791 |
| 24 | Acute encephalopathy (HP:0006846) | 3.03354568 |
| 25 | Lipid accumulation in hepatocytes (HP:0006561) | 3.01425346 |
| 26 | Hypoproteinemia (HP:0003075) | 2.95718789 |
| 27 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.94956241 |
| 28 | Hepatic necrosis (HP:0002605) | 2.94915515 |
| 29 | Renal Fanconi syndrome (HP:0001994) | 2.89126156 |
| 30 | Abnormality of B cell number (HP:0010975) | 2.87810634 |
| 31 | Abolished electroretinogram (ERG) (HP:0000550) | 2.83897578 |
| 32 | Increased serum lactate (HP:0002151) | 2.75239069 |
| 33 | Attenuation of retinal blood vessels (HP:0007843) | 2.73140120 |
| 34 | Lactic acidosis (HP:0003128) | 2.61951877 |
| 35 | Abnormality of eosinophils (HP:0001879) | 2.56884247 |
| 36 | Increased intramyocellular lipid droplets (HP:0012240) | 2.51284723 |
| 37 | Abnormality of the prostate (HP:0008775) | 2.42978890 |
| 38 | Exertional dyspnea (HP:0002875) | 2.42028126 |
| 39 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.41467400 |
| 40 | Cerebral edema (HP:0002181) | 2.39889374 |
| 41 | Pancreatic cysts (HP:0001737) | 2.39255125 |
| 42 | Methylmalonic acidemia (HP:0002912) | 2.35694861 |
| 43 | Optic disc pallor (HP:0000543) | 2.34135493 |
| 44 | Abnormality of T cells (HP:0002843) | 2.32977575 |
| 45 | Type I transferrin isoform profile (HP:0003642) | 2.32707545 |
| 46 | Combined immunodeficiency (HP:0005387) | 2.27045142 |
| 47 | Pendular nystagmus (HP:0012043) | 2.26446253 |
| 48 | Autoimmune thrombocytopenia (HP:0001973) | 2.20303694 |
| 49 | Abnormality of urine glucose concentration (HP:0011016) | 2.20123719 |
| 50 | Glycosuria (HP:0003076) | 2.20123719 |
| 51 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.18345300 |
| 52 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.17423894 |
| 53 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.17423894 |
| 54 | Congenital, generalized hypertrichosis (HP:0004540) | 2.16293460 |
| 55 | Pancytopenia (HP:0001876) | 2.14775403 |
| 56 | Abnormality of serum amino acid levels (HP:0003112) | 2.12167734 |
| 57 | Eosinophilia (HP:0001880) | 2.11253045 |
| 58 | Stomach cancer (HP:0012126) | 2.09920281 |
| 59 | Stomatitis (HP:0010280) | 2.09516473 |
| 60 | Methylmalonic aciduria (HP:0012120) | 2.04335844 |
| 61 | Increased muscle lipid content (HP:0009058) | 1.99215287 |
| 62 | Oral leukoplakia (HP:0002745) | 1.98406197 |
| 63 | B lymphocytopenia (HP:0010976) | 1.97426830 |
| 64 | Abnormality of the renal cortex (HP:0011035) | 1.93468000 |
| 65 | Anorexia (HP:0002039) | 1.93105784 |
| 66 | Respiratory failure (HP:0002878) | 1.90557200 |
| 67 | IgM deficiency (HP:0002850) | 1.90289538 |
| 68 | Abnormal drinking behavior (HP:0030082) | 1.90284439 |
| 69 | Polydipsia (HP:0001959) | 1.90284439 |
| 70 | Hyperphosphaturia (HP:0003109) | 1.89015643 |
| 71 | Lethargy (HP:0001254) | 1.88619703 |
| 72 | Pulmonary embolism (HP:0002204) | 1.85754583 |
| 73 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.84746929 |
| 74 | Abnormality of the labia minora (HP:0012880) | 1.84679447 |
| 75 | Pancreatic fibrosis (HP:0100732) | 1.84403424 |
| 76 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 1.83981650 |
| 77 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.83155312 |
| 78 | Dicarboxylic aciduria (HP:0003215) | 1.83155312 |
| 79 | Abnormal albumin level (HP:0012116) | 1.82785186 |
| 80 | Hypoalbuminemia (HP:0003073) | 1.82785186 |
| 81 | Granulocytopenia (HP:0001913) | 1.82093484 |
| 82 | Chronic otitis media (HP:0000389) | 1.81320802 |
| 83 | Type 2 muscle fiber atrophy (HP:0003554) | 1.80938326 |
| 84 | Abnormality of midbrain morphology (HP:0002418) | 1.80469064 |
| 85 | Molar tooth sign on MRI (HP:0002419) | 1.80469064 |
| 86 | Chronic sinusitis (HP:0011109) | 1.77644524 |
| 87 | Colon cancer (HP:0003003) | 1.77528135 |
| 88 | Abnormality of the ileum (HP:0001549) | 1.77061754 |
| 89 | Severe visual impairment (HP:0001141) | 1.76249832 |
| 90 | Exercise intolerance (HP:0003546) | 1.75457633 |
| 91 | Abnormality of renal resorption (HP:0011038) | 1.74752145 |
| 92 | Hypokalemic alkalosis (HP:0001949) | 1.74598403 |
| 93 | Chronic diarrhea (HP:0002028) | 1.74344561 |
| 94 | Metabolic alkalosis (HP:0200114) | 1.72669729 |
| 95 | Polyuria (HP:0000103) | 1.72225018 |
| 96 | True hermaphroditism (HP:0010459) | 1.71679048 |
| 97 | Abnormal spermatogenesis (HP:0008669) | 1.69237015 |
| 98 | Meckel diverticulum (HP:0002245) | 1.68359919 |
| 99 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.68260943 |
| 100 | Hemoptysis (HP:0002105) | 1.67963712 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MST4 | 3.23016951 |
| 2 | TXK | 3.20685549 |
| 3 | KDR | 2.82907742 |
| 4 | MAP3K12 | 2.74512819 |
| 5 | MAP4K2 | 2.48561187 |
| 6 | VRK2 | 2.32767647 |
| 7 | BUB1 | 2.32132474 |
| 8 | PINK1 | 2.24512207 |
| 9 | ZAK | 2.20520454 |
| 10 | NUAK1 | 2.17590034 |
| 11 | FRK | 2.09433399 |
| 12 | EIF2AK1 | 2.04088791 |
| 13 | ADRBK2 | 2.03772457 |
| 14 | EIF2AK3 | 1.97050516 |
| 15 | BCKDK | 1.93933373 |
| 16 | TLK1 | 1.93701203 |
| 17 | TSSK6 | 1.80158833 |
| 18 | PASK | 1.76786568 |
| 19 | VRK1 | 1.69706481 |
| 20 | CDK19 | 1.57537787 |
| 21 | TESK2 | 1.56399339 |
| 22 | PIK3CG | 1.55372209 |
| 23 | WNK3 | 1.52891511 |
| 24 | CAMKK2 | 1.47674963 |
| 25 | ITK | 1.45173664 |
| 26 | STK16 | 1.37444773 |
| 27 | TRIM28 | 1.34803952 |
| 28 | CCNB1 | 1.30126125 |
| 29 | TEC | 1.29990883 |
| 30 | JAK3 | 1.28955346 |
| 31 | GRK1 | 1.26491792 |
| 32 | TAOK3 | 1.17832405 |
| 33 | PLK3 | 1.13179216 |
| 34 | KIT | 1.11846538 |
| 35 | SCYL2 | 1.10914625 |
| 36 | PLK2 | 1.10660851 |
| 37 | MAP4K1 | 1.09594681 |
| 38 | MYLK | 1.08593192 |
| 39 | NEK1 | 1.05631857 |
| 40 | INSRR | 1.03558758 |
| 41 | BCR | 1.03210093 |
| 42 | SRPK1 | 1.00185363 |
| 43 | ERBB3 | 0.97504458 |
| 44 | SYK | 0.97360389 |
| 45 | WNK4 | 0.96414333 |
| 46 | FES | 0.94378317 |
| 47 | OXSR1 | 0.89283502 |
| 48 | PRKCQ | 0.86366593 |
| 49 | LCK | 0.85369275 |
| 50 | OBSCN | 0.82772847 |
| 51 | CAMKK1 | 0.82575714 |
| 52 | PHKG2 | 0.80210693 |
| 53 | PHKG1 | 0.80210693 |
| 54 | PDK2 | 0.77953267 |
| 55 | IKBKB | 0.76124690 |
| 56 | MAP3K3 | 0.76031563 |
| 57 | SIK3 | 0.75475424 |
| 58 | TIE1 | 0.74368456 |
| 59 | DAPK1 | 0.74267656 |
| 60 | LYN | 0.69082994 |
| 61 | BMPR2 | 0.68760939 |
| 62 | PLK4 | 0.66640260 |
| 63 | BTK | 0.64426646 |
| 64 | ADRBK1 | 0.63119684 |
| 65 | IKBKE | 0.60851314 |
| 66 | BRSK2 | 0.60640080 |
| 67 | PIK3CA | 0.60016103 |
| 68 | MATK | 0.58801461 |
| 69 | GRK6 | 0.57997165 |
| 70 | PBK | 0.57913465 |
| 71 | DYRK2 | 0.56120432 |
| 72 | IGF1R | 0.56020787 |
| 73 | CSF1R | 0.55890867 |
| 74 | CSNK1G2 | 0.54431763 |
| 75 | CSNK1G3 | 0.52600575 |
| 76 | NME1 | 0.50389997 |
| 77 | RPS6KA5 | 0.48965433 |
| 78 | CSNK1G1 | 0.47897245 |
| 79 | TAF1 | 0.45803987 |
| 80 | EGFR | 0.42380536 |
| 81 | RIPK4 | 0.41339395 |
| 82 | FGR | 0.41264028 |
| 83 | PRKCA | 0.39367056 |
| 84 | TNIK | 0.39253030 |
| 85 | DAPK3 | 0.38750751 |
| 86 | PRKCE | 0.38148207 |
| 87 | MAPK13 | 0.37479314 |
| 88 | ILK | 0.37419016 |
| 89 | STK39 | 0.37260901 |
| 90 | GRK7 | 0.36616042 |
| 91 | LIMK1 | 0.36525379 |
| 92 | ACVR1B | 0.36484768 |
| 93 | PRKACA | 0.36412709 |
| 94 | BMPR1B | 0.35153618 |
| 95 | CAMK2A | 0.34695938 |
| 96 | TESK1 | 0.33568888 |
| 97 | CSNK2A1 | 0.33356976 |
| 98 | IRAK4 | 0.33003346 |
| 99 | GRK5 | 0.32474110 |
| 100 | CSNK1A1L | 0.32084945 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.81008789 |
| 2 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.22239300 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.18404690 |
| 4 | Asthma_Homo sapiens_hsa05310 | 3.15793214 |
| 5 | Allograft rejection_Homo sapiens_hsa05330 | 2.98492656 |
| 6 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.98331509 |
| 7 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.70860155 |
| 8 | Parkinsons disease_Homo sapiens_hsa05012 | 2.51398976 |
| 9 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.50278306 |
| 10 | Protein export_Homo sapiens_hsa03060 | 2.22788936 |
| 11 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.15319424 |
| 12 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.14172194 |
| 13 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.94585316 |
| 14 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.83721571 |
| 15 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.76289962 |
| 16 | RNA polymerase_Homo sapiens_hsa03020 | 1.76038698 |
| 17 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.74762959 |
| 18 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.69171928 |
| 19 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.67830508 |
| 20 | Ribosome_Homo sapiens_hsa03010 | 1.61030944 |
| 21 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.57430299 |
| 22 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.54495974 |
| 23 | Alzheimers disease_Homo sapiens_hsa05010 | 1.51833510 |
| 24 | Huntingtons disease_Homo sapiens_hsa05016 | 1.40280398 |
| 25 | Peroxisome_Homo sapiens_hsa04146 | 1.39871981 |
| 26 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.32945038 |
| 27 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.30783723 |
| 28 | RNA degradation_Homo sapiens_hsa03018 | 1.29844529 |
| 29 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.21672886 |
| 30 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.19199756 |
| 31 | Phototransduction_Homo sapiens_hsa04744 | 1.18341478 |
| 32 | Viral myocarditis_Homo sapiens_hsa05416 | 1.13570343 |
| 33 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.13183268 |
| 34 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.12768857 |
| 35 | Homologous recombination_Homo sapiens_hsa03440 | 1.09505453 |
| 36 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.08677394 |
| 37 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.06638057 |
| 38 | DNA replication_Homo sapiens_hsa03030 | 1.03241690 |
| 39 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.02836706 |
| 40 | Mismatch repair_Homo sapiens_hsa03430 | 0.98399969 |
| 41 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.93670403 |
| 42 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.90954550 |
| 43 | Retinol metabolism_Homo sapiens_hsa00830 | 0.90871216 |
| 44 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.90159412 |
| 45 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.89792757 |
| 46 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.88963788 |
| 47 | Basal transcription factors_Homo sapiens_hsa03022 | 0.88489259 |
| 48 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.88443766 |
| 49 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.85288122 |
| 50 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.84205185 |
| 51 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.82209659 |
| 52 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.81374644 |
| 53 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.79159669 |
| 54 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.76700499 |
| 55 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.75098654 |
| 56 | Base excision repair_Homo sapiens_hsa03410 | 0.75003858 |
| 57 | RNA transport_Homo sapiens_hsa03013 | 0.74599695 |
| 58 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.73352960 |
| 59 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.72951884 |
| 60 | Purine metabolism_Homo sapiens_hsa00230 | 0.72880150 |
| 61 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.72653553 |
| 62 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.72457996 |
| 63 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.71186240 |
| 64 | Measles_Homo sapiens_hsa05162 | 0.70266999 |
| 65 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.68104945 |
| 66 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.66237418 |
| 67 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.65483403 |
| 68 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.64230520 |
| 69 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.62517744 |
| 70 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.62457293 |
| 71 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.62390343 |
| 72 | Leishmaniasis_Homo sapiens_hsa05140 | 0.58941464 |
| 73 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.58538764 |
| 74 | Spliceosome_Homo sapiens_hsa03040 | 0.58298521 |
| 75 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.55438092 |
| 76 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.53991507 |
| 77 | Legionellosis_Homo sapiens_hsa05134 | 0.53920066 |
| 78 | Olfactory transduction_Homo sapiens_hsa04740 | 0.52350488 |
| 79 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.51150023 |
| 80 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.50561579 |
| 81 | Metabolic pathways_Homo sapiens_hsa01100 | 0.47861959 |
| 82 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.47843429 |
| 83 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.44581798 |
| 84 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.43524697 |
| 85 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.42874331 |
| 86 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.40964317 |
| 87 | Morphine addiction_Homo sapiens_hsa05032 | 0.40879902 |
| 88 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.40684860 |
| 89 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.36991623 |
| 90 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.36045659 |
| 91 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.34240259 |
| 92 | Nicotine addiction_Homo sapiens_hsa05033 | 0.34091347 |
| 93 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.31070811 |
| 94 | Taste transduction_Homo sapiens_hsa04742 | 0.30701111 |
| 95 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.30457583 |
| 96 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.29748179 |
| 97 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.28906028 |
| 98 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.25202833 |
| 99 | GABAergic synapse_Homo sapiens_hsa04727 | 0.24900805 |
| 100 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.22929773 |

