Rank | Gene Set | Z-score |
---|---|---|
1 | DNA deamination (GO:0045006) | 5.12000392 |
2 | proteasome assembly (GO:0043248) | 4.94276328 |
3 | rRNA modification (GO:0000154) | 4.71205595 |
4 | rRNA methylation (GO:0031167) | 4.61121225 |
5 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.14541284 |
6 | regulation of chronic inflammatory response (GO:0002676) | 4.13951087 |
7 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.95617988 |
8 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.89559373 |
9 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.89559373 |
10 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.77850907 |
11 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.71826929 |
12 | pseudouridine synthesis (GO:0001522) | 3.62120324 |
13 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.61954253 |
14 | negative regulation of ligase activity (GO:0051352) | 3.61954253 |
15 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.60719101 |
16 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.60719101 |
17 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.59785039 |
18 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.59092031 |
19 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.59092031 |
20 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.59092031 |
21 | female mating behavior (GO:0060180) | 3.58639567 |
22 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.57865406 |
23 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.53854903 |
24 | NADH dehydrogenase complex assembly (GO:0010257) | 3.53854903 |
25 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.53854903 |
26 | ether lipid metabolic process (GO:0046485) | 3.50612306 |
27 | ATP synthesis coupled proton transport (GO:0015986) | 3.49020843 |
28 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.49020843 |
29 | protein neddylation (GO:0045116) | 3.48764795 |
30 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.48298003 |
31 | regulation of female receptivity (GO:0045924) | 3.47009214 |
32 | respiratory chain complex IV assembly (GO:0008535) | 3.43253324 |
33 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.42601117 |
34 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.42601117 |
35 | protein complex biogenesis (GO:0070271) | 3.36619272 |
36 | DNA damage response, detection of DNA damage (GO:0042769) | 3.35323317 |
37 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.34261932 |
38 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.32445665 |
39 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.32407604 |
40 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.31120383 |
41 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.30713462 |
42 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.30713462 |
43 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.28964541 |
44 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.23593837 |
45 | tRNA modification (GO:0006400) | 3.22017400 |
46 | positive regulation of prostaglandin secretion (GO:0032308) | 3.19295601 |
47 | positive regulation of cellular response to oxidative stress (GO:1900409) | 3.19084075 |
48 | positive regulation of response to oxidative stress (GO:1902884) | 3.19084075 |
49 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.16638386 |
50 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.13968651 |
51 | positive regulation of ligase activity (GO:0051351) | 3.11826252 |
52 | DNA strand renaturation (GO:0000733) | 3.05576722 |
53 | cellular response to ATP (GO:0071318) | 3.04155201 |
54 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.04094945 |
55 | meiotic chromosome segregation (GO:0045132) | 3.03122008 |
56 | myoblast migration (GO:0051451) | 3.00350639 |
57 | iron ion import (GO:0097286) | 2.95976467 |
58 | purine deoxyribonucleotide catabolic process (GO:0009155) | 2.94097779 |
59 | negative regulation of T-helper cell differentiation (GO:0045623) | 2.93670768 |
60 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 2.93670768 |
61 | mismatch repair (GO:0006298) | 2.91878320 |
62 | GTP biosynthetic process (GO:0006183) | 2.90750700 |
63 | tRNA processing (GO:0008033) | 2.87878591 |
64 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.87521320 |
65 | regulation of cellular amine metabolic process (GO:0033238) | 2.85695190 |
66 | base-excision repair, AP site formation (GO:0006285) | 2.85195437 |
67 | cytochrome complex assembly (GO:0017004) | 2.83917121 |
68 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.82196631 |
69 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.79500421 |
70 | cullin deneddylation (GO:0010388) | 2.78563453 |
71 | piRNA metabolic process (GO:0034587) | 2.76857056 |
72 | protein peptidyl-prolyl isomerization (GO:0000413) | 2.74582858 |
73 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.74499002 |
74 | ribosomal small subunit assembly (GO:0000028) | 2.72350190 |
75 | glycerol ether metabolic process (GO:0006662) | 2.71714602 |
76 | positive regulation of cell cycle arrest (GO:0071158) | 2.71597137 |
77 | behavioral response to nicotine (GO:0035095) | 2.71285870 |
78 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.71182038 |
79 | electron transport chain (GO:0022900) | 2.70481797 |
80 | positive regulation of defense response to virus by host (GO:0002230) | 2.66717847 |
81 | respiratory electron transport chain (GO:0022904) | 2.66231206 |
82 | regulation of prostaglandin secretion (GO:0032306) | 2.66086220 |
83 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 2.60761288 |
84 | L-fucose catabolic process (GO:0042355) | 2.59899677 |
85 | fucose catabolic process (GO:0019317) | 2.59899677 |
86 | L-fucose metabolic process (GO:0042354) | 2.59899677 |
87 | negative regulation of digestive system process (GO:0060457) | 2.58113973 |
88 | regulation of ligase activity (GO:0051340) | 2.57573868 |
89 | tolerance induction (GO:0002507) | 2.56682576 |
90 | regulation of meiosis I (GO:0060631) | 2.56629518 |
91 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 2.56430743 |
92 | tRNA metabolic process (GO:0006399) | 2.55652092 |
93 | hydrogen ion transmembrane transport (GO:1902600) | 2.54102110 |
94 | ether metabolic process (GO:0018904) | 2.53330822 |
95 | negative regulation of protein ubiquitination (GO:0031397) | 2.52676323 |
96 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.52641248 |
97 | peptidyl-histidine modification (GO:0018202) | 2.50049901 |
98 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.47797981 |
99 | deoxyribonucleotide catabolic process (GO:0009264) | 2.47712990 |
100 | termination of RNA polymerase I transcription (GO:0006363) | 2.47321896 |
Rank | Gene Set | Z-score |
---|---|---|
1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.04574003 |
2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.55918032 |
3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.92901004 |
4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.81415440 |
5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.52742964 |
6 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.16071074 |
7 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.09256645 |
8 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.03563461 |
9 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.02230233 |
10 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 3.00741264 |
11 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.89064897 |
12 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.39053283 |
13 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.35159930 |
14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.19544462 |
15 | IRF1_19129219_ChIP-ChIP_H3396_Human | 2.12821305 |
16 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.06954479 |
17 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.98504994 |
18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.95577415 |
19 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.95151076 |
20 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.95064638 |
21 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.94022183 |
22 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.90821711 |
23 | VDR_22108803_ChIP-Seq_LS180_Human | 1.89776734 |
24 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.89729325 |
25 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.89277514 |
26 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.87799809 |
27 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.84264545 |
28 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.84216635 |
29 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.83243076 |
30 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.78285383 |
31 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.77406997 |
32 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.74970489 |
33 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.63103768 |
34 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.61479373 |
35 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.60829118 |
36 | EWS_26573619_Chip-Seq_HEK293_Human | 1.58344348 |
37 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.57625083 |
38 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.53288564 |
39 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.51813673 |
40 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.49944586 |
41 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.48096571 |
42 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.45102001 |
43 | NCOR_22424771_ChIP-Seq_293T_Human | 1.33356421 |
44 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.31630416 |
45 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.31295370 |
46 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.30312650 |
47 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.26125492 |
48 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.25091875 |
49 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.24727700 |
50 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.24666970 |
51 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.21118709 |
52 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.18030287 |
53 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.17525504 |
54 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 1.14950033 |
55 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.14182423 |
56 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.13145335 |
57 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.12648545 |
58 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.12512927 |
59 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.10828699 |
60 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.10479579 |
61 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.10448238 |
62 | P53_21459846_ChIP-Seq_SAOS-2_Human | 1.10144317 |
63 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.09787020 |
64 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.08965758 |
65 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.06918393 |
66 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.06918393 |
67 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.06526633 |
68 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.05922389 |
69 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.05210900 |
70 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.04493896 |
71 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.02815163 |
72 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.01049251 |
73 | AR_20517297_ChIP-Seq_VCAP_Human | 0.99056187 |
74 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.97911475 |
75 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.97911475 |
76 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.97074492 |
77 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.95440460 |
78 | P300_27268052_Chip-Seq_Bcells_Human | 0.95373638 |
79 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.94701295 |
80 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.94633692 |
81 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.94376021 |
82 | ERA_21632823_ChIP-Seq_H3396_Human | 0.94358991 |
83 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.94272492 |
84 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.93844951 |
85 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.93340942 |
86 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.93054192 |
87 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.92372138 |
88 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.92184340 |
89 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92025148 |
90 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.91430193 |
91 | E2F7_22180533_ChIP-Seq_HELA_Human | 0.91007490 |
92 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.88414162 |
93 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.87827829 |
94 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.87651293 |
95 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.85807601 |
96 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.85408687 |
97 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.84859400 |
98 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.84584307 |
99 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.84122390 |
100 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.83612806 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0004147_increased_porphyrin_level | 5.49989573 |
2 | MP0002138_abnormal_hepatobiliary_system | 3.29050837 |
3 | MP0001986_abnormal_taste_sensitivity | 3.17155347 |
4 | MP0005171_absent_coat_pigmentation | 3.09134175 |
5 | MP0001968_abnormal_touch/_nociception | 3.03695162 |
6 | MP0008875_abnormal_xenobiotic_pharmacok | 2.82607353 |
7 | MP0005084_abnormal_gallbladder_morpholo | 2.70439744 |
8 | MP0002736_abnormal_nociception_after | 2.50184738 |
9 | MP0005423_abnormal_somatic_nervous | 2.29662270 |
10 | MP0003806_abnormal_nucleotide_metabolis | 2.25073107 |
11 | MP0003011_delayed_dark_adaptation | 2.19786749 |
12 | MP0006292_abnormal_olfactory_placode | 2.14633653 |
13 | MP0006276_abnormal_autonomic_nervous | 2.12056712 |
14 | MP0003195_calcinosis | 1.97978849 |
15 | MP0003718_maternal_effect | 1.92613734 |
16 | MP0005645_abnormal_hypothalamus_physiol | 1.92389109 |
17 | MP0008058_abnormal_DNA_repair | 1.88604733 |
18 | MP0005083_abnormal_biliary_tract | 1.84805426 |
19 | MP0001873_stomach_inflammation | 1.77709103 |
20 | MP0010094_abnormal_chromosome_stability | 1.77314638 |
21 | MP0005174_abnormal_tail_pigmentation | 1.77312936 |
22 | MP0008877_abnormal_DNA_methylation | 1.76601062 |
23 | MP0008872_abnormal_physiological_respon | 1.71794345 |
24 | MP0002102_abnormal_ear_morphology | 1.65635211 |
25 | MP0003252_abnormal_bile_duct | 1.65325777 |
26 | MP0003122_maternal_imprinting | 1.63928830 |
27 | MP0006036_abnormal_mitochondrial_physio | 1.60318513 |
28 | MP0003646_muscle_fatigue | 1.57199876 |
29 | MP0000685_abnormal_immune_system | 1.55011826 |
30 | MP0003693_abnormal_embryo_hatching | 1.52781616 |
31 | MP0005410_abnormal_fertilization | 1.48037880 |
32 | MP0004043_abnormal_pH_regulation | 1.47368770 |
33 | MP0003121_genomic_imprinting | 1.42316080 |
34 | MP0003111_abnormal_nucleus_morphology | 1.40970263 |
35 | MP0003136_yellow_coat_color | 1.40479926 |
36 | MP0002638_abnormal_pupillary_reflex | 1.38580047 |
37 | MP0002148_abnormal_hypersensitivity_rea | 1.37856985 |
38 | MP0005551_abnormal_eye_electrophysiolog | 1.36572890 |
39 | MP0001970_abnormal_pain_threshold | 1.32699671 |
40 | MP0009764_decreased_sensitivity_to | 1.31936259 |
41 | MP0001919_abnormal_reproductive_system | 1.31399155 |
42 | MP0009333_abnormal_splenocyte_physiolog | 1.28397516 |
43 | MP0002163_abnormal_gland_morphology | 1.24127191 |
44 | MP0002733_abnormal_thermal_nociception | 1.22136073 |
45 | MP0005167_abnormal_blood-brain_barrier | 1.13374774 |
46 | MP0005085_abnormal_gallbladder_physiolo | 1.11371138 |
47 | MP0005365_abnormal_bile_salt | 1.10915561 |
48 | MP0001835_abnormal_antigen_presentation | 1.10484684 |
49 | MP0005379_endocrine/exocrine_gland_phen | 1.10214340 |
50 | MP0001502_abnormal_circadian_rhythm | 1.09548374 |
51 | MP0005389_reproductive_system_phenotype | 1.07266804 |
52 | MP0004145_abnormal_muscle_electrophysio | 1.07196377 |
53 | MP0002277_abnormal_respiratory_mucosa | 1.05565711 |
54 | MP0001188_hyperpigmentation | 1.03531463 |
55 | MP0002210_abnormal_sex_determination | 1.02937092 |
56 | MP0001293_anophthalmia | 1.02166461 |
57 | MP0003787_abnormal_imprinting | 1.01956559 |
58 | MP0000230_abnormal_systemic_arterial | 1.01717030 |
59 | MP0003786_premature_aging | 1.01137950 |
60 | MP0005636_abnormal_mineral_homeostasis | 0.99831164 |
61 | MP0004782_abnormal_surfactant_physiolog | 0.99778216 |
62 | MP0003880_abnormal_central_pattern | 0.99119173 |
63 | MP0001501_abnormal_sleep_pattern | 0.95472812 |
64 | MP0004957_abnormal_blastocyst_morpholog | 0.92515250 |
65 | MP0001929_abnormal_gametogenesis | 0.89430247 |
66 | MP0005671_abnormal_response_to | 0.87080109 |
67 | MP0002909_abnormal_adrenal_gland | 0.86253691 |
68 | MP0002160_abnormal_reproductive_system | 0.84480244 |
69 | MP0001800_abnormal_humoral_immune | 0.83794040 |
70 | MP0002653_abnormal_ependyma_morphology | 0.83297217 |
71 | MP0004381_abnormal_hair_follicle | 0.82423792 |
72 | MP0004142_abnormal_muscle_tone | 0.82041397 |
73 | MP0003763_abnormal_thymus_physiology | 0.81531174 |
74 | MP0001790_abnormal_immune_system | 0.81292718 |
75 | MP0005387_immune_system_phenotype | 0.81292718 |
76 | MP0008057_abnormal_DNA_replication | 0.80114443 |
77 | MP0000653_abnormal_sex_gland | 0.79401876 |
78 | MP0002006_tumorigenesis | 0.79068662 |
79 | MP0001145_abnormal_male_reproductive | 0.78569964 |
80 | MP0005332_abnormal_amino_acid | 0.77606085 |
81 | MP0001756_abnormal_urination | 0.76798972 |
82 | MP0001905_abnormal_dopamine_level | 0.76642779 |
83 | MP0009745_abnormal_behavioral_response | 0.76607780 |
84 | MP0003866_abnormal_defecation | 0.74803667 |
85 | MP0002254_reproductive_system_inflammat | 0.74688427 |
86 | MP0003656_abnormal_erythrocyte_physiolo | 0.73687542 |
87 | MP0001764_abnormal_homeostasis | 0.73178341 |
88 | MP0003698_abnormal_male_reproductive | 0.72492539 |
89 | MP0006035_abnormal_mitochondrial_morpho | 0.72042000 |
90 | MP0009785_altered_susceptibility_to | 0.71108052 |
91 | MP0001661_extended_life_span | 0.70830355 |
92 | MP0004133_heterotaxia | 0.69108154 |
93 | MP0002876_abnormal_thyroid_physiology | 0.67111980 |
94 | MP0004742_abnormal_vestibular_system | 0.67039521 |
95 | MP0000689_abnormal_spleen_morphology | 0.66579177 |
96 | MP0001765_abnormal_ion_homeostasis | 0.66120526 |
97 | MP0003936_abnormal_reproductive_system | 0.65203067 |
98 | MP0003077_abnormal_cell_cycle | 0.64605148 |
99 | MP0000372_irregular_coat_pigmentation | 0.64083273 |
100 | MP0002837_dystrophic_cardiac_calcinosis | 0.63407186 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Increased hepatocellular lipid droplets (HP:0006565) | 4.26108758 |
2 | Lipid accumulation in hepatocytes (HP:0006561) | 3.85092641 |
3 | Mitochondrial inheritance (HP:0001427) | 3.81093975 |
4 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.78554202 |
5 | Acute necrotizing encephalopathy (HP:0006965) | 3.75558136 |
6 | Attenuation of retinal blood vessels (HP:0007843) | 3.66716219 |
7 | Congenital stationary night blindness (HP:0007642) | 3.64509347 |
8 | Increased CSF lactate (HP:0002490) | 3.63921415 |
9 | Acute encephalopathy (HP:0006846) | 3.57580612 |
10 | Abnormality of the pons (HP:0007361) | 3.52780798 |
11 | Hepatocellular necrosis (HP:0001404) | 3.39252920 |
12 | Hypoplasia of the pons (HP:0012110) | 3.25795023 |
13 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 3.22709761 |
14 | Pendular nystagmus (HP:0012043) | 3.16853249 |
15 | Increased serum lactate (HP:0002151) | 3.11234923 |
16 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.11143264 |
17 | Renal Fanconi syndrome (HP:0001994) | 3.08923352 |
18 | Hepatic necrosis (HP:0002605) | 3.03626719 |
19 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.99396665 |
20 | Testicular atrophy (HP:0000029) | 2.98675005 |
21 | Progressive macrocephaly (HP:0004481) | 2.94936525 |
22 | Colon cancer (HP:0003003) | 2.91863655 |
23 | Exertional dyspnea (HP:0002875) | 2.77417994 |
24 | Increased intramyocellular lipid droplets (HP:0012240) | 2.69139562 |
25 | Mesangial abnormality (HP:0001966) | 2.67400047 |
26 | Nephronophthisis (HP:0000090) | 2.63842915 |
27 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.56231191 |
28 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.55949257 |
29 | Small hand (HP:0200055) | 2.50940292 |
30 | Patellar aplasia (HP:0006443) | 2.50561801 |
31 | Optic disc pallor (HP:0000543) | 2.48669893 |
32 | Type 2 muscle fiber atrophy (HP:0003554) | 2.45059025 |
33 | Bony spicule pigmentary retinopathy (HP:0007737) | 2.43357427 |
34 | Absent thumb (HP:0009777) | 2.40485669 |
35 | Cerebellar dysplasia (HP:0007033) | 2.38031876 |
36 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.37642844 |
37 | Rib fusion (HP:0000902) | 2.37380993 |
38 | Autoimmune hemolytic anemia (HP:0001890) | 2.35612194 |
39 | Lactic acidosis (HP:0003128) | 2.33723286 |
40 | Type II lissencephaly (HP:0007260) | 2.33609814 |
41 | 3-Methylglutaconic aciduria (HP:0003535) | 2.31516687 |
42 | Carpal bone hypoplasia (HP:0001498) | 2.31280295 |
43 | Pancreatic cysts (HP:0001737) | 2.29185881 |
44 | Panhypogammaglobulinemia (HP:0003139) | 2.28579757 |
45 | Facial diplegia (HP:0001349) | 2.25769754 |
46 | Progressive microcephaly (HP:0000253) | 2.25315582 |
47 | Abnormal albumin level (HP:0012116) | 2.23927320 |
48 | Hypoalbuminemia (HP:0003073) | 2.23927320 |
49 | Severe muscular hypotonia (HP:0006829) | 2.22836690 |
50 | Dyschromatopsia (HP:0007641) | 2.21610339 |
51 | Abnormality of midbrain morphology (HP:0002418) | 2.16629925 |
52 | Molar tooth sign on MRI (HP:0002419) | 2.16629925 |
53 | Abnormality of renal resorption (HP:0011038) | 2.16422378 |
54 | Delayed CNS myelination (HP:0002188) | 2.16005677 |
55 | Cerebral edema (HP:0002181) | 2.15545139 |
56 | Polydipsia (HP:0001959) | 2.14812519 |
57 | Abnormal drinking behavior (HP:0030082) | 2.14812519 |
58 | Congenital, generalized hypertrichosis (HP:0004540) | 2.13694623 |
59 | Abolished electroretinogram (ERG) (HP:0000550) | 2.13133728 |
60 | Increased muscle lipid content (HP:0009058) | 2.12768127 |
61 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.11635041 |
62 | Methylmalonic aciduria (HP:0012120) | 2.10991091 |
63 | Methylmalonic acidemia (HP:0002912) | 2.07587388 |
64 | Ependymoma (HP:0002888) | 2.06704753 |
65 | Increased serum pyruvate (HP:0003542) | 2.06663253 |
66 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.04274303 |
67 | Exercise intolerance (HP:0003546) | 2.02530640 |
68 | Short humerus (HP:0005792) | 1.99145186 |
69 | Chorioretinal atrophy (HP:0000533) | 1.99115069 |
70 | Glycosuria (HP:0003076) | 1.98851792 |
71 | Abnormality of urine glucose concentration (HP:0011016) | 1.98851792 |
72 | Microvesicular hepatic steatosis (HP:0001414) | 1.98738488 |
73 | Fibular aplasia (HP:0002990) | 1.98035867 |
74 | Tubular atrophy (HP:0000092) | 1.97427868 |
75 | Meckel diverticulum (HP:0002245) | 1.97399304 |
76 | Muscle fiber atrophy (HP:0100295) | 1.94415882 |
77 | Abnormal number of erythroid precursors (HP:0012131) | 1.94271715 |
78 | Abnormality of the anterior horn cell (HP:0006802) | 1.94199993 |
79 | Degeneration of anterior horn cells (HP:0002398) | 1.94199993 |
80 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.93651833 |
81 | Abnormality of the ileum (HP:0001549) | 1.91663929 |
82 | Polyuria (HP:0000103) | 1.90383476 |
83 | Abnormality of B cell number (HP:0010975) | 1.89085890 |
84 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 1.88310291 |
85 | Opisthotonus (HP:0002179) | 1.88039904 |
86 | IgG deficiency (HP:0004315) | 1.86309768 |
87 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.85543961 |
88 | Aplastic anemia (HP:0001915) | 1.85458200 |
89 | Decreased circulating renin level (HP:0003351) | 1.83478845 |
90 | Cerebral hypomyelination (HP:0006808) | 1.82939171 |
91 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.82702311 |
92 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.82702311 |
93 | Abnormality of T cell physiology (HP:0011840) | 1.80775052 |
94 | Decreased central vision (HP:0007663) | 1.80125821 |
95 | Duplicated collecting system (HP:0000081) | 1.79868526 |
96 | Abnormality of the renal medulla (HP:0100957) | 1.79606145 |
97 | Respiratory difficulties (HP:0002880) | 1.79147329 |
98 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.78302517 |
99 | B lymphocytopenia (HP:0010976) | 1.77451241 |
100 | Agitation (HP:0000713) | 1.77405234 |
Rank | Gene Set | Z-score |
---|---|---|
1 | NEK1 | 3.54582519 |
2 | WNK4 | 3.22920834 |
3 | VRK2 | 3.22692781 |
4 | TSSK6 | 2.98713465 |
5 | ADRBK2 | 2.81019271 |
6 | EIF2AK3 | 2.75923883 |
7 | TLK1 | 2.72696399 |
8 | NUAK1 | 2.60658804 |
9 | BUB1 | 2.53624992 |
10 | EPHA4 | 2.30891166 |
11 | PLK4 | 2.26003038 |
12 | SRPK1 | 2.24310007 |
13 | TNIK | 2.11859451 |
14 | CDK8 | 2.07207338 |
15 | TRIM28 | 2.01651670 |
16 | GRK1 | 1.93903409 |
17 | VRK1 | 1.91604830 |
18 | PBK | 1.91496302 |
19 | WNK3 | 1.82812208 |
20 | MST4 | 1.79149724 |
21 | IRAK2 | 1.77830502 |
22 | MAP3K4 | 1.72494820 |
23 | MAPK15 | 1.56966062 |
24 | TXK | 1.55183032 |
25 | BMPR1B | 1.48313171 |
26 | MAPKAPK3 | 1.47425964 |
27 | PLK2 | 1.39798360 |
28 | NME1 | 1.39357620 |
29 | DYRK2 | 1.33016515 |
30 | MUSK | 1.30431102 |
31 | CAMKK2 | 1.20724466 |
32 | PINK1 | 1.18725222 |
33 | ACVR1B | 1.18038184 |
34 | PLK3 | 1.15621160 |
35 | CSNK1G3 | 1.14890867 |
36 | CDK19 | 1.09590190 |
37 | PHKG1 | 1.09432331 |
38 | PHKG2 | 1.09432331 |
39 | CSNK1G2 | 1.07004365 |
40 | EIF2AK1 | 1.05324507 |
41 | MAP4K2 | 1.02270708 |
42 | PRKCG | 1.00019363 |
43 | CSNK1G1 | 0.91578671 |
44 | ZAK | 0.91339823 |
45 | BCR | 0.88696768 |
46 | CCNB1 | 0.88016509 |
47 | TAOK3 | 0.87528550 |
48 | MKNK1 | 0.87283603 |
49 | DAPK1 | 0.86642663 |
50 | BCKDK | 0.86346139 |
51 | EIF2AK2 | 0.86175151 |
52 | TAF1 | 0.84916461 |
53 | OXSR1 | 0.83636256 |
54 | ADRBK1 | 0.79369870 |
55 | TGFBR1 | 0.78714017 |
56 | MAPK13 | 0.76103020 |
57 | CSNK1A1L | 0.73478536 |
58 | CAMK1 | 0.72580201 |
59 | INSRR | 0.71094941 |
60 | SIK3 | 0.69220001 |
61 | MKNK2 | 0.68782217 |
62 | TIE1 | 0.67833929 |
63 | IRAK4 | 0.64622535 |
64 | KIT | 0.63479567 |
65 | FLT3 | 0.63292979 |
66 | WNK1 | 0.61781093 |
67 | TEC | 0.61775751 |
68 | MARK3 | 0.61268981 |
69 | NME2 | 0.58657186 |
70 | PLK1 | 0.58250518 |
71 | SCYL2 | 0.54873251 |
72 | GRK6 | 0.51594947 |
73 | MAPKAPK5 | 0.51409885 |
74 | FRK | 0.51296264 |
75 | STK39 | 0.49813504 |
76 | PRKCH | 0.48506414 |
77 | ATR | 0.46720629 |
78 | SYK | 0.45659070 |
79 | MAP2K7 | 0.44864276 |
80 | TTK | 0.44804930 |
81 | PRKCI | 0.43979324 |
82 | ITK | 0.42118642 |
83 | CAMK4 | 0.41447919 |
84 | PKN2 | 0.41384788 |
85 | MAP2K6 | 0.40981924 |
86 | PRKCE | 0.40544998 |
87 | CSNK1D | 0.40102317 |
88 | DAPK2 | 0.39491084 |
89 | MINK1 | 0.39307340 |
90 | RPS6KA5 | 0.37849572 |
91 | PDK2 | 0.36440890 |
92 | STK16 | 0.36430090 |
93 | RPS6KA6 | 0.35626974 |
94 | PAK6 | 0.34578884 |
95 | RPS6KB1 | 0.32570509 |
96 | STK38L | 0.31953153 |
97 | PRKCQ | 0.31921576 |
98 | MAP4K1 | 0.31348770 |
99 | CSNK2A2 | 0.29139323 |
100 | PASK | 0.28013646 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 4.88720060 |
2 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 3.48918296 |
3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.85674560 |
4 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.60934301 |
5 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.58584116 |
6 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.52222190 |
7 | Parkinsons disease_Homo sapiens_hsa05012 | 2.39941910 |
8 | Ribosome_Homo sapiens_hsa03010 | 2.17811939 |
9 | RNA polymerase_Homo sapiens_hsa03020 | 2.12618444 |
10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.09539673 |
11 | Base excision repair_Homo sapiens_hsa03410 | 2.04270020 |
12 | Sulfur relay system_Homo sapiens_hsa04122 | 2.03563427 |
13 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.00605723 |
14 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.95999212 |
15 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.94862680 |
16 | Mismatch repair_Homo sapiens_hsa03430 | 1.93942305 |
17 | Asthma_Homo sapiens_hsa05310 | 1.89125157 |
18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.87555396 |
19 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.86431454 |
20 | Protein export_Homo sapiens_hsa03060 | 1.68255210 |
21 | Homologous recombination_Homo sapiens_hsa03440 | 1.67500551 |
22 | Alzheimers disease_Homo sapiens_hsa05010 | 1.65564734 |
23 | Huntingtons disease_Homo sapiens_hsa05016 | 1.65543724 |
24 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.56901483 |
25 | DNA replication_Homo sapiens_hsa03030 | 1.54408397 |
26 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.45643451 |
27 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.42056206 |
28 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.40529589 |
29 | Phototransduction_Homo sapiens_hsa04744 | 1.35624039 |
30 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.34560122 |
31 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.32612542 |
32 | RNA transport_Homo sapiens_hsa03013 | 1.29682491 |
33 | RNA degradation_Homo sapiens_hsa03018 | 1.26383758 |
34 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.25106377 |
35 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.20706034 |
36 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.20096391 |
37 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.16108920 |
38 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.11740541 |
39 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.11243684 |
40 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.09671266 |
41 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.07512023 |
42 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.06123606 |
43 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.02298837 |
44 | Spliceosome_Homo sapiens_hsa03040 | 1.01698928 |
45 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.01350275 |
46 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.00649529 |
47 | Allograft rejection_Homo sapiens_hsa05330 | 0.95516422 |
48 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.95236881 |
49 | Purine metabolism_Homo sapiens_hsa00230 | 0.94732829 |
50 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.93866263 |
51 | Taste transduction_Homo sapiens_hsa04742 | 0.92043803 |
52 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.91157574 |
53 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.90761097 |
54 | Peroxisome_Homo sapiens_hsa04146 | 0.89855608 |
55 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.83630974 |
56 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.82241959 |
57 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.81267145 |
58 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.79879341 |
59 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.79774495 |
60 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.77969922 |
61 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.76486394 |
62 | Metabolic pathways_Homo sapiens_hsa01100 | 0.76329646 |
63 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.75035038 |
64 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.69916235 |
65 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.69004694 |
66 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.68085194 |
67 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.61756997 |
68 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.60008257 |
69 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.59135758 |
70 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.56900667 |
71 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.56706001 |
72 | Nicotine addiction_Homo sapiens_hsa05033 | 0.55820173 |
73 | Morphine addiction_Homo sapiens_hsa05032 | 0.53759761 |
74 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.52765740 |
75 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.51920562 |
76 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.51717129 |
77 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.48503585 |
78 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.46206728 |
79 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.45995283 |
80 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.44523110 |
81 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.43791286 |
82 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.43221371 |
83 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.40907976 |
84 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.40705085 |
85 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.39956296 |
86 | Carbon metabolism_Homo sapiens_hsa01200 | 0.39188308 |
87 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.38925841 |
88 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.37846885 |
89 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.37291641 |
90 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.29313619 |
91 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.27295830 |
92 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.26809467 |
93 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.25230413 |
94 | Retinol metabolism_Homo sapiens_hsa00830 | 0.24362171 |
95 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.23473888 |
96 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.22828272 |
97 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.22587679 |
98 | Cell cycle_Homo sapiens_hsa04110 | 0.22145341 |
99 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.21040991 |
100 | GABAergic synapse_Homo sapiens_hsa04727 | 0.20543748 |