PSMA6P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.12000392
2proteasome assembly (GO:0043248)4.94276328
3rRNA modification (GO:0000154)4.71205595
4rRNA methylation (GO:0031167)4.61121225
5negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.14541284
6regulation of chronic inflammatory response (GO:0002676)4.13951087
7regulation of cellular amino acid metabolic process (GO:0006521)3.95617988
8somatic hypermutation of immunoglobulin genes (GO:0016446)3.89559373
9somatic diversification of immune receptors via somatic mutation (GO:0002566)3.89559373
10positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.77850907
11DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.71826929
12pseudouridine synthesis (GO:0001522)3.62120324
13negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.61954253
14negative regulation of ligase activity (GO:0051352)3.61954253
15signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.60719101
16intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.60719101
17water-soluble vitamin biosynthetic process (GO:0042364)3.59785039
18signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.59092031
19signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.59092031
20signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.59092031
21female mating behavior (GO:0060180)3.58639567
22regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.57865406
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.53854903
24NADH dehydrogenase complex assembly (GO:0010257)3.53854903
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.53854903
26ether lipid metabolic process (GO:0046485)3.50612306
27ATP synthesis coupled proton transport (GO:0015986)3.49020843
28energy coupled proton transport, down electrochemical gradient (GO:0015985)3.49020843
29protein neddylation (GO:0045116)3.48764795
30signal transduction involved in cell cycle checkpoint (GO:0072395)3.48298003
31regulation of female receptivity (GO:0045924)3.47009214
32respiratory chain complex IV assembly (GO:0008535)3.43253324
33signal transduction involved in DNA integrity checkpoint (GO:0072401)3.42601117
34signal transduction involved in DNA damage checkpoint (GO:0072422)3.42601117
35protein complex biogenesis (GO:0070271)3.36619272
36DNA damage response, detection of DNA damage (GO:0042769)3.35323317
37anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.34261932
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.32445665
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32407604
40positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.31120383
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.30713462
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.30713462
43establishment of protein localization to mitochondrial membrane (GO:0090151)3.28964541
44mitochondrial respiratory chain complex assembly (GO:0033108)3.23593837
45tRNA modification (GO:0006400)3.22017400
46positive regulation of prostaglandin secretion (GO:0032308)3.19295601
47positive regulation of cellular response to oxidative stress (GO:1900409)3.19084075
48positive regulation of response to oxidative stress (GO:1902884)3.19084075
49preassembly of GPI anchor in ER membrane (GO:0016254)3.16638386
50regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.13968651
51positive regulation of ligase activity (GO:0051351)3.11826252
52DNA strand renaturation (GO:0000733)3.05576722
53cellular response to ATP (GO:0071318)3.04155201
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.04094945
55meiotic chromosome segregation (GO:0045132)3.03122008
56myoblast migration (GO:0051451)3.00350639
57iron ion import (GO:0097286)2.95976467
58purine deoxyribonucleotide catabolic process (GO:0009155)2.94097779
59negative regulation of T-helper cell differentiation (GO:0045623)2.93670768
60negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.93670768
61mismatch repair (GO:0006298)2.91878320
62GTP biosynthetic process (GO:0006183)2.90750700
63tRNA processing (GO:0008033)2.87878591
64DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.87521320
65regulation of cellular amine metabolic process (GO:0033238)2.85695190
66base-excision repair, AP site formation (GO:0006285)2.85195437
67cytochrome complex assembly (GO:0017004)2.83917121
68folic acid-containing compound biosynthetic process (GO:0009396)2.82196631
69mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.79500421
70cullin deneddylation (GO:0010388)2.78563453
71piRNA metabolic process (GO:0034587)2.76857056
72protein peptidyl-prolyl isomerization (GO:0000413)2.74582858
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.74499002
74ribosomal small subunit assembly (GO:0000028)2.72350190
75glycerol ether metabolic process (GO:0006662)2.71714602
76positive regulation of cell cycle arrest (GO:0071158)2.71597137
77behavioral response to nicotine (GO:0035095)2.71285870
78regulation of ubiquitin-protein transferase activity (GO:0051438)2.71182038
79electron transport chain (GO:0022900)2.70481797
80positive regulation of defense response to virus by host (GO:0002230)2.66717847
81respiratory electron transport chain (GO:0022904)2.66231206
82regulation of prostaglandin secretion (GO:0032306)2.66086220
83regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.60761288
84L-fucose catabolic process (GO:0042355)2.59899677
85fucose catabolic process (GO:0019317)2.59899677
86L-fucose metabolic process (GO:0042354)2.59899677
87negative regulation of digestive system process (GO:0060457)2.58113973
88regulation of ligase activity (GO:0051340)2.57573868
89tolerance induction (GO:0002507)2.56682576
90regulation of meiosis I (GO:0060631)2.56629518
91negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.56430743
92tRNA metabolic process (GO:0006399)2.55652092
93hydrogen ion transmembrane transport (GO:1902600)2.54102110
94ether metabolic process (GO:0018904)2.53330822
95negative regulation of protein ubiquitination (GO:0031397)2.52676323
96antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.52641248
97peptidyl-histidine modification (GO:0018202)2.50049901
98regulation of nuclear cell cycle DNA replication (GO:0033262)2.47797981
99deoxyribonucleotide catabolic process (GO:0009264)2.47712990
100termination of RNA polymerase I transcription (GO:0006363)2.47321896

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.04574003
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.55918032
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.92901004
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.81415440
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.52742964
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.16071074
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.09256645
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.03563461
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.02230233
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.00741264
11VDR_23849224_ChIP-Seq_CD4+_Human2.89064897
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.39053283
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35159930
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19544462
15IRF1_19129219_ChIP-ChIP_H3396_Human2.12821305
16FOXP3_21729870_ChIP-Seq_TREG_Human2.06954479
17DCP1A_22483619_ChIP-Seq_HELA_Human1.98504994
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95577415
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.95151076
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.95064638
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94022183
22ELK1_19687146_ChIP-ChIP_HELA_Human1.90821711
23VDR_22108803_ChIP-Seq_LS180_Human1.89776734
24ZNF274_21170338_ChIP-Seq_K562_Hela1.89729325
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89277514
26XRN2_22483619_ChIP-Seq_HELA_Human1.87799809
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84264545
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84216635
29TP53_22573176_ChIP-Seq_HFKS_Human1.83243076
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.78285383
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.77406997
32MYC_18940864_ChIP-ChIP_HL60_Human1.74970489
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63103768
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61479373
35GABP_19822575_ChIP-Seq_HepG2_Human1.60829118
36EWS_26573619_Chip-Seq_HEK293_Human1.58344348
37EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.57625083
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.53288564
39DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.51813673
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49944586
41CIITA_25753668_ChIP-Seq_RAJI_Human1.48096571
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45102001
43NCOR_22424771_ChIP-Seq_293T_Human1.33356421
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31630416
45GATA3_21878914_ChIP-Seq_MCF-7_Human1.31295370
46RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30312650
47PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.26125492
48TAF2_19829295_ChIP-Seq_ESCs_Human1.25091875
49TTF2_22483619_ChIP-Seq_HELA_Human1.24727700
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24666970
51NANOG_20526341_ChIP-Seq_ESCs_Human1.21118709
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18030287
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17525504
54EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.14950033
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.14182423
56BCL6_27268052_Chip-Seq_Bcells_Human1.13145335
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12648545
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12512927
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10828699
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10479579
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.10448238
62P53_21459846_ChIP-Seq_SAOS-2_Human1.10144317
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09787020
64YY1_22570637_ChIP-Seq_MALME-3M_Human1.08965758
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06918393
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.06918393
67KDM5A_27292631_Chip-Seq_BREAST_Human1.06526633
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05922389
69E2F1_20622854_ChIP-Seq_HELA_Human1.05210900
70MYC_19829295_ChIP-Seq_ESCs_Human1.04493896
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02815163
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01049251
73AR_20517297_ChIP-Seq_VCAP_Human0.99056187
74CBP_20019798_ChIP-Seq_JUKART_Human0.97911475
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97911475
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97074492
77IRF8_22096565_ChIP-ChIP_GC-B_Human0.95440460
78P300_27268052_Chip-Seq_Bcells_Human0.95373638
79SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94701295
80IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94633692
81FOXP1_21924763_ChIP-Seq_HESCs_Human0.94376021
82ERA_21632823_ChIP-Seq_H3396_Human0.94358991
83HOXB7_26014856_ChIP-Seq_BT474_Human0.94272492
84OCT4_20526341_ChIP-Seq_ESCs_Human0.93844951
85TP63_19390658_ChIP-ChIP_HaCaT_Human0.93340942
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93054192
87ERG_20517297_ChIP-Seq_VCAP_Human0.92372138
88RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92184340
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92025148
90CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91430193
91E2F7_22180533_ChIP-Seq_HELA_Human0.91007490
92GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.88414162
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.87827829
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87651293
95GATA6_21074721_ChIP-Seq_CACO-2_Human0.85807601
96FOXH1_21741376_ChIP-Seq_ESCs_Human0.85408687
97MYC_19079543_ChIP-ChIP_MESCs_Mouse0.84859400
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84584307
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84122390
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83612806

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level5.49989573
2MP0002138_abnormal_hepatobiliary_system3.29050837
3MP0001986_abnormal_taste_sensitivity3.17155347
4MP0005171_absent_coat_pigmentation3.09134175
5MP0001968_abnormal_touch/_nociception3.03695162
6MP0008875_abnormal_xenobiotic_pharmacok2.82607353
7MP0005084_abnormal_gallbladder_morpholo2.70439744
8MP0002736_abnormal_nociception_after2.50184738
9MP0005423_abnormal_somatic_nervous2.29662270
10MP0003806_abnormal_nucleotide_metabolis2.25073107
11MP0003011_delayed_dark_adaptation2.19786749
12MP0006292_abnormal_olfactory_placode2.14633653
13MP0006276_abnormal_autonomic_nervous2.12056712
14MP0003195_calcinosis1.97978849
15MP0003718_maternal_effect1.92613734
16MP0005645_abnormal_hypothalamus_physiol1.92389109
17MP0008058_abnormal_DNA_repair1.88604733
18MP0005083_abnormal_biliary_tract1.84805426
19MP0001873_stomach_inflammation1.77709103
20MP0010094_abnormal_chromosome_stability1.77314638
21MP0005174_abnormal_tail_pigmentation1.77312936
22MP0008877_abnormal_DNA_methylation1.76601062
23MP0008872_abnormal_physiological_respon1.71794345
24MP0002102_abnormal_ear_morphology1.65635211
25MP0003252_abnormal_bile_duct1.65325777
26MP0003122_maternal_imprinting1.63928830
27MP0006036_abnormal_mitochondrial_physio1.60318513
28MP0003646_muscle_fatigue1.57199876
29MP0000685_abnormal_immune_system1.55011826
30MP0003693_abnormal_embryo_hatching1.52781616
31MP0005410_abnormal_fertilization1.48037880
32MP0004043_abnormal_pH_regulation1.47368770
33MP0003121_genomic_imprinting1.42316080
34MP0003111_abnormal_nucleus_morphology1.40970263
35MP0003136_yellow_coat_color1.40479926
36MP0002638_abnormal_pupillary_reflex1.38580047
37MP0002148_abnormal_hypersensitivity_rea1.37856985
38MP0005551_abnormal_eye_electrophysiolog1.36572890
39MP0001970_abnormal_pain_threshold1.32699671
40MP0009764_decreased_sensitivity_to1.31936259
41MP0001919_abnormal_reproductive_system1.31399155
42MP0009333_abnormal_splenocyte_physiolog1.28397516
43MP0002163_abnormal_gland_morphology1.24127191
44MP0002733_abnormal_thermal_nociception1.22136073
45MP0005167_abnormal_blood-brain_barrier1.13374774
46MP0005085_abnormal_gallbladder_physiolo1.11371138
47MP0005365_abnormal_bile_salt1.10915561
48MP0001835_abnormal_antigen_presentation1.10484684
49MP0005379_endocrine/exocrine_gland_phen1.10214340
50MP0001502_abnormal_circadian_rhythm1.09548374
51MP0005389_reproductive_system_phenotype1.07266804
52MP0004145_abnormal_muscle_electrophysio1.07196377
53MP0002277_abnormal_respiratory_mucosa1.05565711
54MP0001188_hyperpigmentation1.03531463
55MP0002210_abnormal_sex_determination1.02937092
56MP0001293_anophthalmia1.02166461
57MP0003787_abnormal_imprinting1.01956559
58MP0000230_abnormal_systemic_arterial1.01717030
59MP0003786_premature_aging1.01137950
60MP0005636_abnormal_mineral_homeostasis0.99831164
61MP0004782_abnormal_surfactant_physiolog0.99778216
62MP0003880_abnormal_central_pattern0.99119173
63MP0001501_abnormal_sleep_pattern0.95472812
64MP0004957_abnormal_blastocyst_morpholog0.92515250
65MP0001929_abnormal_gametogenesis0.89430247
66MP0005671_abnormal_response_to0.87080109
67MP0002909_abnormal_adrenal_gland0.86253691
68MP0002160_abnormal_reproductive_system0.84480244
69MP0001800_abnormal_humoral_immune0.83794040
70MP0002653_abnormal_ependyma_morphology0.83297217
71MP0004381_abnormal_hair_follicle0.82423792
72MP0004142_abnormal_muscle_tone0.82041397
73MP0003763_abnormal_thymus_physiology0.81531174
74MP0001790_abnormal_immune_system0.81292718
75MP0005387_immune_system_phenotype0.81292718
76MP0008057_abnormal_DNA_replication0.80114443
77MP0000653_abnormal_sex_gland0.79401876
78MP0002006_tumorigenesis0.79068662
79MP0001145_abnormal_male_reproductive0.78569964
80MP0005332_abnormal_amino_acid0.77606085
81MP0001756_abnormal_urination0.76798972
82MP0001905_abnormal_dopamine_level0.76642779
83MP0009745_abnormal_behavioral_response0.76607780
84MP0003866_abnormal_defecation0.74803667
85MP0002254_reproductive_system_inflammat0.74688427
86MP0003656_abnormal_erythrocyte_physiolo0.73687542
87MP0001764_abnormal_homeostasis0.73178341
88MP0003698_abnormal_male_reproductive0.72492539
89MP0006035_abnormal_mitochondrial_morpho0.72042000
90MP0009785_altered_susceptibility_to0.71108052
91MP0001661_extended_life_span0.70830355
92MP0004133_heterotaxia0.69108154
93MP0002876_abnormal_thyroid_physiology0.67111980
94MP0004742_abnormal_vestibular_system0.67039521
95MP0000689_abnormal_spleen_morphology0.66579177
96MP0001765_abnormal_ion_homeostasis0.66120526
97MP0003936_abnormal_reproductive_system0.65203067
98MP0003077_abnormal_cell_cycle0.64605148
99MP0000372_irregular_coat_pigmentation0.64083273
100MP0002837_dystrophic_cardiac_calcinosis0.63407186

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.26108758
2Lipid accumulation in hepatocytes (HP:0006561)3.85092641
3Mitochondrial inheritance (HP:0001427)3.81093975
4Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.78554202
5Acute necrotizing encephalopathy (HP:0006965)3.75558136
6Attenuation of retinal blood vessels (HP:0007843)3.66716219
7Congenital stationary night blindness (HP:0007642)3.64509347
8Increased CSF lactate (HP:0002490)3.63921415
9Acute encephalopathy (HP:0006846)3.57580612
10Abnormality of the pons (HP:0007361)3.52780798
11Hepatocellular necrosis (HP:0001404)3.39252920
12Hypoplasia of the pons (HP:0012110)3.25795023
13Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.22709761
14Pendular nystagmus (HP:0012043)3.16853249
15Increased serum lactate (HP:0002151)3.11234923
16Abnormal mitochondria in muscle tissue (HP:0008316)3.11143264
17Renal Fanconi syndrome (HP:0001994)3.08923352
18Hepatic necrosis (HP:0002605)3.03626719
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.99396665
20Testicular atrophy (HP:0000029)2.98675005
21Progressive macrocephaly (HP:0004481)2.94936525
22Colon cancer (HP:0003003)2.91863655
23Exertional dyspnea (HP:0002875)2.77417994
24Increased intramyocellular lipid droplets (HP:0012240)2.69139562
25Mesangial abnormality (HP:0001966)2.67400047
26Nephronophthisis (HP:0000090)2.63842915
27Aplasia/hypoplasia of the humerus (HP:0006507)2.56231191
28Aplasia/Hypoplasia of the patella (HP:0006498)2.55949257
29Small hand (HP:0200055)2.50940292
30Patellar aplasia (HP:0006443)2.50561801
31Optic disc pallor (HP:0000543)2.48669893
32Type 2 muscle fiber atrophy (HP:0003554)2.45059025
33Bony spicule pigmentary retinopathy (HP:0007737)2.43357427
34Absent thumb (HP:0009777)2.40485669
35Cerebellar dysplasia (HP:0007033)2.38031876
36Abnormal rod and cone electroretinograms (HP:0008323)2.37642844
37Rib fusion (HP:0000902)2.37380993
38Autoimmune hemolytic anemia (HP:0001890)2.35612194
39Lactic acidosis (HP:0003128)2.33723286
40Type II lissencephaly (HP:0007260)2.33609814
413-Methylglutaconic aciduria (HP:0003535)2.31516687
42Carpal bone hypoplasia (HP:0001498)2.31280295
43Pancreatic cysts (HP:0001737)2.29185881
44Panhypogammaglobulinemia (HP:0003139)2.28579757
45Facial diplegia (HP:0001349)2.25769754
46Progressive microcephaly (HP:0000253)2.25315582
47Abnormal albumin level (HP:0012116)2.23927320
48Hypoalbuminemia (HP:0003073)2.23927320
49Severe muscular hypotonia (HP:0006829)2.22836690
50Dyschromatopsia (HP:0007641)2.21610339
51Abnormality of midbrain morphology (HP:0002418)2.16629925
52Molar tooth sign on MRI (HP:0002419)2.16629925
53Abnormality of renal resorption (HP:0011038)2.16422378
54Delayed CNS myelination (HP:0002188)2.16005677
55Cerebral edema (HP:0002181)2.15545139
56Polydipsia (HP:0001959)2.14812519
57Abnormal drinking behavior (HP:0030082)2.14812519
58Congenital, generalized hypertrichosis (HP:0004540)2.13694623
59Abolished electroretinogram (ERG) (HP:0000550)2.13133728
60Increased muscle lipid content (HP:0009058)2.12768127
61Elevated erythrocyte sedimentation rate (HP:0003565)2.11635041
62Methylmalonic aciduria (HP:0012120)2.10991091
63Methylmalonic acidemia (HP:0002912)2.07587388
64Ependymoma (HP:0002888)2.06704753
65Increased serum pyruvate (HP:0003542)2.06663253
66Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04274303
67Exercise intolerance (HP:0003546)2.02530640
68Short humerus (HP:0005792)1.99145186
69Chorioretinal atrophy (HP:0000533)1.99115069
70Glycosuria (HP:0003076)1.98851792
71Abnormality of urine glucose concentration (HP:0011016)1.98851792
72Microvesicular hepatic steatosis (HP:0001414)1.98738488
73Fibular aplasia (HP:0002990)1.98035867
74Tubular atrophy (HP:0000092)1.97427868
75Meckel diverticulum (HP:0002245)1.97399304
76Muscle fiber atrophy (HP:0100295)1.94415882
77Abnormal number of erythroid precursors (HP:0012131)1.94271715
78Abnormality of the anterior horn cell (HP:0006802)1.94199993
79Degeneration of anterior horn cells (HP:0002398)1.94199993
80Decreased electroretinogram (ERG) amplitude (HP:0000654)1.93651833
81Abnormality of the ileum (HP:0001549)1.91663929
82Polyuria (HP:0000103)1.90383476
83Abnormality of B cell number (HP:0010975)1.89085890
84Abnormal delayed hypersensitivity skin test (HP:0002963)1.88310291
85Opisthotonus (HP:0002179)1.88039904
86IgG deficiency (HP:0004315)1.86309768
87Aplasia/Hypoplasia involving the musculature (HP:0001460)1.85543961
88Aplastic anemia (HP:0001915)1.85458200
89Decreased circulating renin level (HP:0003351)1.83478845
90Cerebral hypomyelination (HP:0006808)1.82939171
91Decreased activity of mitochondrial respiratory chain (HP:0008972)1.82702311
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.82702311
93Abnormality of T cell physiology (HP:0011840)1.80775052
94Decreased central vision (HP:0007663)1.80125821
95Duplicated collecting system (HP:0000081)1.79868526
96Abnormality of the renal medulla (HP:0100957)1.79606145
97Respiratory difficulties (HP:0002880)1.79147329
98Abnormality of cells of the erythroid lineage (HP:0012130)1.78302517
99B lymphocytopenia (HP:0010976)1.77451241
100Agitation (HP:0000713)1.77405234

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK13.54582519
2WNK43.22920834
3VRK23.22692781
4TSSK62.98713465
5ADRBK22.81019271
6EIF2AK32.75923883
7TLK12.72696399
8NUAK12.60658804
9BUB12.53624992
10EPHA42.30891166
11PLK42.26003038
12SRPK12.24310007
13TNIK2.11859451
14CDK82.07207338
15TRIM282.01651670
16GRK11.93903409
17VRK11.91604830
18PBK1.91496302
19WNK31.82812208
20MST41.79149724
21IRAK21.77830502
22MAP3K41.72494820
23MAPK151.56966062
24TXK1.55183032
25BMPR1B1.48313171
26MAPKAPK31.47425964
27PLK21.39798360
28NME11.39357620
29DYRK21.33016515
30MUSK1.30431102
31CAMKK21.20724466
32PINK11.18725222
33ACVR1B1.18038184
34PLK31.15621160
35CSNK1G31.14890867
36CDK191.09590190
37PHKG11.09432331
38PHKG21.09432331
39CSNK1G21.07004365
40EIF2AK11.05324507
41MAP4K21.02270708
42PRKCG1.00019363
43CSNK1G10.91578671
44ZAK0.91339823
45BCR0.88696768
46CCNB10.88016509
47TAOK30.87528550
48MKNK10.87283603
49DAPK10.86642663
50BCKDK0.86346139
51EIF2AK20.86175151
52TAF10.84916461
53OXSR10.83636256
54ADRBK10.79369870
55TGFBR10.78714017
56MAPK130.76103020
57CSNK1A1L0.73478536
58CAMK10.72580201
59INSRR0.71094941
60SIK30.69220001
61MKNK20.68782217
62TIE10.67833929
63IRAK40.64622535
64KIT0.63479567
65FLT30.63292979
66WNK10.61781093
67TEC0.61775751
68MARK30.61268981
69NME20.58657186
70PLK10.58250518
71SCYL20.54873251
72GRK60.51594947
73MAPKAPK50.51409885
74FRK0.51296264
75STK390.49813504
76PRKCH0.48506414
77ATR0.46720629
78SYK0.45659070
79MAP2K70.44864276
80TTK0.44804930
81PRKCI0.43979324
82ITK0.42118642
83CAMK40.41447919
84PKN20.41384788
85MAP2K60.40981924
86PRKCE0.40544998
87CSNK1D0.40102317
88DAPK20.39491084
89MINK10.39307340
90RPS6KA50.37849572
91PDK20.36440890
92STK160.36430090
93RPS6KA60.35626974
94PAK60.34578884
95RPS6KB10.32570509
96STK38L0.31953153
97PRKCQ0.31921576
98MAP4K10.31348770
99CSNK2A20.29139323
100PASK0.28013646

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.88720060
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.48918296
3Oxidative phosphorylation_Homo sapiens_hsa001902.85674560
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.60934301
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.58584116
6One carbon pool by folate_Homo sapiens_hsa006702.52222190
7Parkinsons disease_Homo sapiens_hsa050122.39941910
8Ribosome_Homo sapiens_hsa030102.17811939
9RNA polymerase_Homo sapiens_hsa030202.12618444
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09539673
11Base excision repair_Homo sapiens_hsa034102.04270020
12Sulfur relay system_Homo sapiens_hsa041222.03563427
13Fanconi anemia pathway_Homo sapiens_hsa034602.00605723
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95999212
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.94862680
16Mismatch repair_Homo sapiens_hsa034301.93942305
17Asthma_Homo sapiens_hsa053101.89125157
18Basal transcription factors_Homo sapiens_hsa030221.87555396
19Primary immunodeficiency_Homo sapiens_hsa053401.86431454
20Protein export_Homo sapiens_hsa030601.68255210
21Homologous recombination_Homo sapiens_hsa034401.67500551
22Alzheimers disease_Homo sapiens_hsa050101.65564734
23Huntingtons disease_Homo sapiens_hsa050161.65543724
24Propanoate metabolism_Homo sapiens_hsa006401.56901483
25DNA replication_Homo sapiens_hsa030301.54408397
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45643451
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42056206
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40529589
29Phototransduction_Homo sapiens_hsa047441.35624039
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34560122
31Nucleotide excision repair_Homo sapiens_hsa034201.32612542
32RNA transport_Homo sapiens_hsa030131.29682491
33RNA degradation_Homo sapiens_hsa030181.26383758
34Pyrimidine metabolism_Homo sapiens_hsa002401.25106377
35Type I diabetes mellitus_Homo sapiens_hsa049401.20706034
36Pyruvate metabolism_Homo sapiens_hsa006201.20096391
37Linoleic acid metabolism_Homo sapiens_hsa005911.16108920
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11740541
39Cardiac muscle contraction_Homo sapiens_hsa042601.11243684
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09671266
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.07512023
42Butanoate metabolism_Homo sapiens_hsa006501.06123606
43Autoimmune thyroid disease_Homo sapiens_hsa053201.02298837
44Spliceosome_Homo sapiens_hsa030401.01698928
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01350275
46Sulfur metabolism_Homo sapiens_hsa009201.00649529
47Allograft rejection_Homo sapiens_hsa053300.95516422
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95236881
49Purine metabolism_Homo sapiens_hsa002300.94732829
50Steroid biosynthesis_Homo sapiens_hsa001000.93866263
51Taste transduction_Homo sapiens_hsa047420.92043803
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.91157574
53Fat digestion and absorption_Homo sapiens_hsa049750.90761097
54Peroxisome_Homo sapiens_hsa041460.89855608
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83630974
56Tryptophan metabolism_Homo sapiens_hsa003800.82241959
57Hematopoietic cell lineage_Homo sapiens_hsa046400.81267145
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79879341
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79774495
60Nitrogen metabolism_Homo sapiens_hsa009100.77969922
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76486394
62Metabolic pathways_Homo sapiens_hsa011000.76329646
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.75035038
64Ether lipid metabolism_Homo sapiens_hsa005650.69916235
65Non-homologous end-joining_Homo sapiens_hsa034500.69004694
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68085194
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61756997
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.60008257
69Graft-versus-host disease_Homo sapiens_hsa053320.59135758
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56900667
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56706001
72Nicotine addiction_Homo sapiens_hsa050330.55820173
73Morphine addiction_Homo sapiens_hsa050320.53759761
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52765740
75Folate biosynthesis_Homo sapiens_hsa007900.51920562
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.51717129
77Arachidonic acid metabolism_Homo sapiens_hsa005900.48503585
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.46206728
79Collecting duct acid secretion_Homo sapiens_hsa049660.45995283
80Antigen processing and presentation_Homo sapiens_hsa046120.44523110
81Chemical carcinogenesis_Homo sapiens_hsa052040.43791286
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43221371
83Fatty acid degradation_Homo sapiens_hsa000710.40907976
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40705085
85Ovarian steroidogenesis_Homo sapiens_hsa049130.39956296
86Carbon metabolism_Homo sapiens_hsa012000.39188308
87Serotonergic synapse_Homo sapiens_hsa047260.38925841
88Vitamin B6 metabolism_Homo sapiens_hsa007500.37846885
89beta-Alanine metabolism_Homo sapiens_hsa004100.37291641
90Caffeine metabolism_Homo sapiens_hsa002320.29313619
91Selenocompound metabolism_Homo sapiens_hsa004500.27295830
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.26809467
93Fatty acid elongation_Homo sapiens_hsa000620.25230413
94Retinol metabolism_Homo sapiens_hsa008300.24362171
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23473888
96Biosynthesis of amino acids_Homo sapiens_hsa012300.22828272
97Rheumatoid arthritis_Homo sapiens_hsa053230.22587679
98Cell cycle_Homo sapiens_hsa041100.22145341
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21040991
100GABAergic synapse_Homo sapiens_hsa047270.20543748

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