PSMA6P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)9.40768524
2regulation of acrosome reaction (GO:0060046)8.63973241
3regulation of protein glycosylation (GO:0060049)8.13645883
4sphingosine metabolic process (GO:0006670)8.06146784
5positive regulation of cAMP-mediated signaling (GO:0043950)7.93715598
6negative regulation of nitric oxide biosynthetic process (GO:0045019)7.80737909
7diol metabolic process (GO:0034311)7.32374329
8piRNA metabolic process (GO:0034587)7.20574539
9thrombin receptor signaling pathway (GO:0070493)6.90752481
10sphingoid metabolic process (GO:0046519)6.82724544
11negative regulation of glycoprotein biosynthetic process (GO:0010561)6.64355870
12glycerol ether metabolic process (GO:0006662)6.55460641
13notochord development (GO:0030903)6.48150693
14ether metabolic process (GO:0018904)6.06357274
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.84207990
16cellular response to ammonium ion (GO:0071242)5.67226927
17regulation of glutamate receptor signaling pathway (GO:1900449)5.66207826
18DNA replication-dependent nucleosome organization (GO:0034723)5.44539546
19DNA replication-dependent nucleosome assembly (GO:0006335)5.44539546
20signal complex assembly (GO:0007172)5.42514385
21mRNA cleavage (GO:0006379)5.17811790
22regulation of cAMP-mediated signaling (GO:0043949)5.09880797
23ncRNA catabolic process (GO:0034661)5.03474258
24pyrimidine dimer repair (GO:0006290)4.97773081
25negative regulation of glycoprotein metabolic process (GO:1903019)4.97261251
26cellular response to alkaloid (GO:0071312)4.34722115
27negative regulation of cell-matrix adhesion (GO:0001953)4.30170560
28regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.24087997
29regulation of female receptivity (GO:0045924)4.14751516
30negative regulation of adenylate cyclase activity (GO:0007194)4.13462108
31regulation of translational elongation (GO:0006448)4.13174208
32glomerular visceral epithelial cell development (GO:0072015)4.01826586
33negative regulation of exocytosis (GO:0045920)3.98906483
34negative regulation of cyclase activity (GO:0031280)3.94137047
35vitamin catabolic process (GO:0009111)3.90521902
36fat-soluble vitamin catabolic process (GO:0042363)3.90521902
37N-terminal protein amino acid acetylation (GO:0006474)3.78557921
38cell-cell junction maintenance (GO:0045217)3.77210484
39glycosphingolipid metabolic process (GO:0006687)3.74045634
40negative regulation of lyase activity (GO:0051350)3.72350865
41regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.65732000
42coenzyme catabolic process (GO:0009109)3.65263836
43female mating behavior (GO:0060180)3.63538024
44response to morphine (GO:0043278)3.57669532
45glomerular epithelial cell development (GO:0072310)3.52142237
46cornea development in camera-type eye (GO:0061303)3.40481294
47response to isoquinoline alkaloid (GO:0014072)3.40375416
48RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.39994571
49omega-hydroxylase P450 pathway (GO:0097267)3.38749973
50wound healing, spreading of epidermal cells (GO:0035313)3.37482695
51chemical homeostasis within a tissue (GO:0048875)3.32101896
52regulation of odontogenesis (GO:0042481)3.29091307
53dopamine receptor signaling pathway (GO:0007212)3.27377255
54positive regulation of nitric oxide biosynthetic process (GO:0045429)3.25972271
55DNA synthesis involved in DNA repair (GO:0000731)3.24027766
56positive regulation of cardiac muscle cell differentiation (GO:2000727)3.22424870
57thyroid hormone generation (GO:0006590)3.19619290
58detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.18045772
59viral mRNA export from host cell nucleus (GO:0046784)3.16255657
60regulation of memory T cell differentiation (GO:0043380)3.10230825
61neuronal action potential (GO:0019228)3.08318384
62positive regulation of icosanoid secretion (GO:0032305)3.01341474
63glycolipid metabolic process (GO:0006664)3.01092253
64regulation of calcium ion-dependent exocytosis (GO:0017158)3.00862635
65positive regulation of fatty acid transport (GO:2000193)2.99203960
66membrane lipid metabolic process (GO:0006643)2.98974901
67positive regulation of cholesterol efflux (GO:0010875)2.98655043
68positive regulation of protein complex disassembly (GO:0043243)2.96923965
69smooth muscle tissue development (GO:0048745)2.96669234
70left/right axis specification (GO:0070986)2.94893080
71membrane depolarization during action potential (GO:0086010)2.94668464
72surfactant homeostasis (GO:0043129)2.94453896
73negative regulation of cAMP biosynthetic process (GO:0030818)2.92878856
74regulation of cytokine production involved in inflammatory response (GO:1900015)2.88994998
75sensory perception of pain (GO:0019233)2.87603979
76cell junction maintenance (GO:0034331)2.87062888
77thyroid hormone metabolic process (GO:0042403)2.86574471
78response to caffeine (GO:0031000)2.82520635
79negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.82153287
80liposaccharide metabolic process (GO:1903509)2.81886110
81polyol biosynthetic process (GO:0046173)2.80502191
82nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.74747862
83glomerular basement membrane development (GO:0032836)2.72876545
84positive regulation of sterol transport (GO:0032373)2.70989184
85positive regulation of cholesterol transport (GO:0032376)2.70989184
86ribonucleoprotein complex disassembly (GO:0032988)2.70975427
87glycerophospholipid catabolic process (GO:0046475)2.69901291
88regulation of glycoprotein biosynthetic process (GO:0010559)2.67029900
89negative regulation of nucleotide biosynthetic process (GO:0030809)2.65459631
90negative regulation of purine nucleotide biosynthetic process (GO:1900372)2.65459631
91protein localization to synapse (GO:0035418)2.64205747
92spermatid development (GO:0007286)2.63059937
93negative regulation of cytosolic calcium ion concentration (GO:0051481)16.3030404
94negative regulation of cAMP-mediated signaling (GO:0043951)13.6405979
95opioid receptor signaling pathway (GO:0038003)12.5203365
96ether lipid metabolic process (GO:0046485)11.4857832
97regulation of translational termination (GO:0006449)11.0457551
98behavioral response to ethanol (GO:0048149)11.0395962
99negative regulation of calcium ion-dependent exocytosis (GO:0045955)10.8153743
100adult feeding behavior (GO:0008343)10.3740763

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.49685342
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.29787758
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse4.09911385
4VDR_22108803_ChIP-Seq_LS180_Human3.95127382
5TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.37050466
6POU5F1_26923725_Chip-Seq_MESODERM_Mouse3.37050466
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.18739274
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.18232714
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.03626731
10RXR_22108803_ChIP-Seq_LS180_Human2.90790394
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.81456951
12EGR1_19032775_ChIP-ChIP_M12_Human2.60768559
13TAF15_26573619_Chip-Seq_HEK293_Human2.56046039
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.14475264
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12686273
16HTT_18923047_ChIP-ChIP_STHdh_Human2.08476533
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.04102518
18PCGF2_27294783_Chip-Seq_NPCs_Mouse1.97806268
19GBX2_23144817_ChIP-Seq_PC3_Human1.96912034
20NANOG_19829295_ChIP-Seq_ESCs_Human1.96100842
21SOX2_19829295_ChIP-Seq_ESCs_Human1.96100842
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.86092258
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84572054
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.84431873
25ZNF274_21170338_ChIP-Seq_K562_Hela1.80695054
26CBP_20019798_ChIP-Seq_JUKART_Human1.79934571
27IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.79934571
28BCAT_22108803_ChIP-Seq_LS180_Human1.70067906
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.62736593
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61168685
31TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.53406364
32CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52224133
33TCF4_23295773_ChIP-Seq_U87_Human1.51210968
34NANOG_20526341_ChIP-Seq_ESCs_Human1.51151732
35IRF1_19129219_ChIP-ChIP_H3396_Human1.44745758
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.41017566
37DROSHA_22980978_ChIP-Seq_HELA_Human1.38735021
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38445233
39STAT3_23295773_ChIP-Seq_U87_Human1.37843301
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.35577315
41PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.34885364
42FLI1_21867929_ChIP-Seq_TH2_Mouse1.34130547
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33453368
44SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.31199685
45TP53_18474530_ChIP-ChIP_U2OS_Human1.29538504
46CDX2_22108803_ChIP-Seq_LS180_Human1.27299592
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24970514
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23712255
49FOXH1_21741376_ChIP-Seq_ESCs_Human1.23234121
50CRX_20693478_ChIP-Seq_RETINA_Mouse1.21224621
51MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20718348
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20406710
53TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.20044590
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19900538
55SCL_19346495_ChIP-Seq_HPC-7_Human1.19298146
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.19148329
57CEBPB_22108803_ChIP-Seq_LS180_Human1.18947657
58RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.16724429
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15497783
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.15205954
61VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15025404
62RUNX_20019798_ChIP-Seq_JUKART_Human1.12700986
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11704381
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11010295
65OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08173639
66TP53_22573176_ChIP-Seq_HFKS_Human1.04581494
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.04514986
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.03303944
69PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02850498
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01853860
71SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01641670
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01626487
73P300_19829295_ChIP-Seq_ESCs_Human1.01281004
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00631591
75FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99515731
76LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98851403
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98247526
78SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97968455
79TP53_16413492_ChIP-PET_HCT116_Human0.96998438
80RAC3_21632823_ChIP-Seq_H3396_Human0.96924491
81TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95602413
82CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95465364
83AR_25329375_ChIP-Seq_VCAP_Human0.95065973
84GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.94369965
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93810846
86OCT1_27270436_Chip-Seq_PROSTATE_Human0.93406779
87CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92498368
88IGF1R_20145208_ChIP-Seq_DFB_Human0.92258086
89KDM2B_26808549_Chip-Seq_REH_Human0.90769882
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89390444
91EP300_21415370_ChIP-Seq_HL-1_Mouse0.89139851
92PIAS1_25552417_ChIP-Seq_VCAP_Human0.88949927
93EGR1_23403033_ChIP-Seq_LIVER_Mouse0.87091480
94RNF2_27304074_Chip-Seq_NSC_Mouse0.86893380
95TP63_23658742_ChIP-Seq_EP156T_Human0.86005235
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85873485
97TCF4_22108803_ChIP-Seq_LS180_Human0.85798033
98ESR1_20079471_ChIP-ChIP_T-47D_Human0.85357874
99GATA3_21867929_ChIP-Seq_TH1_Mouse0.84732622
100AR_21572438_ChIP-Seq_LNCaP_Human0.83787285

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow7.04243624
2MP0009780_abnormal_chondrocyte_physiolo6.55793688
3MP0002876_abnormal_thyroid_physiology5.67414516
4MP0005360_urolithiasis4.27054197
5MP0005503_abnormal_tendon_morphology4.19133867
6MP0001968_abnormal_touch/_nociception3.93765345
7MP0000678_abnormal_parathyroid_gland3.74861448
8MP0003941_abnormal_skin_development3.36837845
9MP0009764_decreased_sensitivity_to2.89908470
10MP0000681_abnormal_thyroid_gland2.73772734
11MP0003880_abnormal_central_pattern2.73154029
12MP0001545_abnormal_hematopoietic_system2.67365426
13MP0005397_hematopoietic_system_phenotyp2.67365426
14MP0009333_abnormal_splenocyte_physiolog2.30670547
15MP0001501_abnormal_sleep_pattern2.29111308
16MP0003045_fibrosis2.26926906
17MP0006035_abnormal_mitochondrial_morpho2.21391853
18MP0005646_abnormal_pituitary_gland2.20899197
19MP0003183_abnormal_peptide_metabolism2.19853740
20MP0001664_abnormal_digestion2.18781352
21MP0003191_abnormal_cellular_cholesterol2.04511219
22MP0005551_abnormal_eye_electrophysiolog2.02219181
23MP0003950_abnormal_plasma_membrane1.87755687
24MP0002249_abnormal_larynx_morphology1.87160941
25MP0010234_abnormal_vibrissa_follicle1.78269636
26MP0008057_abnormal_DNA_replication1.77854581
27MP0003633_abnormal_nervous_system1.72955437
28MP0002796_impaired_skin_barrier1.62119056
29MP0003879_abnormal_hair_cell1.61688215
30MP0003638_abnormal_response/metabolism_1.52116623
31MP0003959_abnormal_lean_body1.50899779
32MP0004858_abnormal_nervous_system1.50391186
33MP0005645_abnormal_hypothalamus_physiol1.50213343
34MP0003195_calcinosis1.44553673
35MP0002733_abnormal_thermal_nociception1.41416914
36MP0009046_muscle_twitch1.30153554
37MP0002971_abnormal_brown_adipose1.24268678
38MP0003567_abnormal_fetal_cardiomyocyte1.22325734
39MP0003646_muscle_fatigue1.22182271
40MP0004782_abnormal_surfactant_physiolog1.18300315
41MP0009745_abnormal_behavioral_response1.16264135
42MP0001881_abnormal_mammary_gland1.14836422
43MP0002272_abnormal_nervous_system1.07628128
44MP0000015_abnormal_ear_pigmentation1.07242270
45MP0009765_abnormal_xenobiotic_induced1.03434000
46MP0004147_increased_porphyrin_level0.94883973
47MP0005501_abnormal_skin_physiology0.94715147
48MP0001270_distended_abdomen0.93115255
49MP0002148_abnormal_hypersensitivity_rea0.92867744
50MP0003631_nervous_system_phenotype0.92037809
51MP0000749_muscle_degeneration0.91619351
52MP0002168_other_aberrant_phenotype0.91316778
53MP0001486_abnormal_startle_reflex0.88435929
54MP0000230_abnormal_systemic_arterial0.86269393
55MP0005670_abnormal_white_adipose0.84567431
56MP0010771_integument_phenotype0.83955241
57MP0001970_abnormal_pain_threshold0.83519997
58MP0002693_abnormal_pancreas_physiology0.81345262
59MP0005334_abnormal_fat_pad0.77795497
60MP0002108_abnormal_muscle_morphology0.75412557
61MP0008775_abnormal_heart_ventricle0.74870502
62MP0008874_decreased_physiological_sensi0.74170297
63MP0005310_abnormal_salivary_gland0.73699133
64MP0003937_abnormal_limbs/digits/tail_de0.72623709
65MP0003868_abnormal_feces_composition0.70696574
66MP0009384_cardiac_valve_regurgitation0.70685856
67MP0004859_abnormal_synaptic_plasticity0.67994620
68MP0004264_abnormal_extraembryonic_tissu0.67533220
69MP0000049_abnormal_middle_ear0.67329442
70MP0004130_abnormal_muscle_cell0.67135635
71MP0005195_abnormal_posterior_eye0.65876031
72MP0005167_abnormal_blood-brain_barrier0.63505762
73MP0000358_abnormal_cell_content/0.62252725
74MP0001919_abnormal_reproductive_system0.60798676
75MP0000569_abnormal_digit_pigmentation0.58120944
76MP0002229_neurodegeneration0.57126550
77MP0009672_abnormal_birth_weight0.56617945
78MP0008872_abnormal_physiological_respon0.56515919
79MP0006054_spinal_hemorrhage0.52459240
80MP0002557_abnormal_social/conspecific_i0.50948483
81MP0009053_abnormal_anal_canal0.50279325
82MP0004084_abnormal_cardiac_muscle0.47063887
83MP0005452_abnormal_adipose_tissue0.45996450
84MP0000685_abnormal_immune_system0.44588092
85MP0001324_abnormal_eye_pigmentation0.43536002
86MP0002069_abnormal_eating/drinking_beha0.43482662
87MP0003936_abnormal_reproductive_system0.42886114
88MP0002998_abnormal_bone_remodeling0.42425351
89MP0003635_abnormal_synaptic_transmissio0.42011384
90MP0009643_abnormal_urine_homeostasis0.41874745
91MP0002063_abnormal_learning/memory/cond0.41355219
92MP0004085_abnormal_heartbeat0.40852764
93MP0006072_abnormal_retinal_apoptosis0.39786256
94MP0002064_seizures0.39118404
95MP0000751_myopathy0.38895605
96MP0005390_skeleton_phenotype0.38798350
97MP0005369_muscle_phenotype0.37971750
98MP0001756_abnormal_urination0.37226565
99MP0010678_abnormal_skin_adnexa0.36338832
100MP0002067_abnormal_sensory_capabilities0.36070041

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)7.85865774
2Intestinal atresia (HP:0011100)7.10004650
3Abnormality of the aortic arch (HP:0012303)6.62675161
4Pancreatic islet-cell hyperplasia (HP:0004510)6.55719061
5Broad alveolar ridges (HP:0000187)6.15519697
6Thickened helices (HP:0000391)5.80245883
7Large for gestational age (HP:0001520)5.47559554
8Poor head control (HP:0002421)5.40535691
9Oligodontia (HP:0000677)5.25705211
10Agitation (HP:0000713)4.69183485
11Congenital ichthyosiform erythroderma (HP:0007431)4.65346734
12Focal motor seizures (HP:0011153)4.57264875
13Mesangial abnormality (HP:0001966)4.46147230
14Abnormality of endocrine pancreas physiology (HP:0012093)4.36859922
15Abnormality of the pancreatic islet cells (HP:0006476)4.36859922
16Gaze-evoked nystagmus (HP:0000640)4.09581360
17Abnormality of the ileum (HP:0001549)3.86895436
18Large eyes (HP:0001090)3.85607759
19Tented upper lip vermilion (HP:0010804)3.62575858
20Myositis (HP:0100614)3.56918332
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.50226458
22Gastrointestinal atresia (HP:0002589)3.41954845
23Tubular atrophy (HP:0000092)3.31667125
24Hypoproteinemia (HP:0003075)3.24694899
25Abnormality of the alveolar ridges (HP:0006477)3.13755716
26Hyperpituitarism (HP:0010514)3.11903434
27Chromsome breakage (HP:0040012)3.06936012
28Orchitis (HP:0100796)3.01956384
29Cerebellar dysplasia (HP:0007033)2.84552836
30Poor speech (HP:0002465)2.82882934
31Nephroblastoma (Wilms tumor) (HP:0002667)2.80790266
32Hyperthyroidism (HP:0000836)2.80481862
33Type II lissencephaly (HP:0007260)2.76949749
34Neonatal respiratory distress (HP:0002643)2.69181149
35Embryonal renal neoplasm (HP:0011794)2.64619652
36Ectropion (HP:0000656)2.61377570
37Optic nerve hypoplasia (HP:0000609)2.56447902
38Dialeptic seizures (HP:0011146)2.53462040
39Focal seizures (HP:0007359)2.52306792
40Elevated erythrocyte sedimentation rate (HP:0003565)2.47450037
41Nonprogressive disorder (HP:0003680)2.47359672
42Long nose (HP:0003189)2.47056355
43Broad-based gait (HP:0002136)2.46617276
44Restlessness (HP:0000711)2.38275207
45Hypoplasia of the brainstem (HP:0002365)2.38035847
46Aplasia/Hypoplasia of the brainstem (HP:0007362)2.38035847
47High anterior hairline (HP:0009890)2.36343867
48Striae distensae (HP:0001065)2.35835041
49Goiter (HP:0000853)2.28922869
50Entropion (HP:0000621)2.27429331
51Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.26811760
52Abnormality of macular pigmentation (HP:0008002)2.25607263
53Progressive inability to walk (HP:0002505)2.23899120
54Lissencephaly (HP:0001339)2.23229353
55Generalized tonic-clonic seizures (HP:0002069)2.22571636
56Pili torti (HP:0003777)2.22021740
57Abnormality of nail color (HP:0100643)2.15766731
58Impulsivity (HP:0100710)2.14242473
59Amelogenesis imperfecta (HP:0000705)2.12820545
60Keratoconus (HP:0000563)2.10934157
61Increased corneal curvature (HP:0100692)2.10934157
62Poikiloderma (HP:0001029)2.10619065
63Dysdiadochokinesis (HP:0002075)2.10569908
64Abnormality of the vitreous humor (HP:0004327)2.10565679
65Hypercortisolism (HP:0001578)2.04417543
66Abnormality of proline metabolism (HP:0010907)2.03183903
67Hydroxyprolinuria (HP:0003080)2.03183903
68Peritonitis (HP:0002586)2.01322105
69Thyroid-stimulating hormone excess (HP:0002925)14.9771061
70Hypohidrosis (HP:0000966)1.99477624
71Abnormal hair laboratory examination (HP:0003328)1.97296491
72Hypoplasia of the pons (HP:0012110)1.96502021
73Abnormality of the columella (HP:0009929)1.95864781
74Attenuation of retinal blood vessels (HP:0007843)1.95191296
75Muscular dystrophy (HP:0003560)1.93159132
76Pendular nystagmus (HP:0012043)1.93032393
77Ileus (HP:0002595)1.92224113
78Central scotoma (HP:0000603)1.89526357
79Congenital stationary night blindness (HP:0007642)1.86709836
80Testicular neoplasm (HP:0010788)1.84844502
81Autoimmune hemolytic anemia (HP:0001890)1.84000958
82Lack of skin elasticity (HP:0100679)1.82223120
83Hamartoma (HP:0010566)1.80881191
84Cutaneous melanoma (HP:0012056)1.79258886
85Abnormality of glycolipid metabolism (HP:0010969)1.78523869
86Abnormality of liposaccharide metabolism (HP:0010968)1.78523869
87Abnormality of glycosphingolipid metabolism (HP:0004343)1.78523869
88Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77083551
89Non-midline cleft lip (HP:0100335)1.75694754
90Scotoma (HP:0000575)1.75338736
91Abnormality of the pons (HP:0007361)1.70752592
92Episodic fever (HP:0001954)1.66538664
93Atonic seizures (HP:0010819)1.65983133
94Round face (HP:0000311)1.65959802
95Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.64884842
96Neoplasm of the lung (HP:0100526)1.64821564
97Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.62029800
98Severe visual impairment (HP:0001141)1.61894329
993-Methylglutaconic aciduria (HP:0003535)1.59906602
100Retrobulbar optic neuritis (HP:0100654)1.59330069

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.60909461
2FRK5.45940182
3PINK13.73774862
4IRAK33.29007758
5ADRBK12.95823279
6PNCK2.14678460
7IRAK12.02755094
8TYRO32.02400676
9ADRBK211.5724897
10PRKCG1.95865579
11RIPK11.83313658
12PRKCE1.73933562
13TGFBR11.72301071
14ACVR1B1.71911071
15DYRK31.70978739
16MAPK111.51842769
17CLK11.33335162
18PLK21.08978327
19GRK11.04432203
20NEK91.04213019
21BMPR1B0.99279854
22CAMK2A0.85917846
23PRKCI0.81073189
24CAMK1G0.79694696
25BRSK10.69530839
26ERBB20.64207213
27GRK70.62730697
28STK38L0.59097778
29EIF2AK30.58646592
30STK30.55753307
31MKNK10.54293036
32MAPKAPK50.53201174
33TAOK30.51635972
34STK380.49383862
35GRK50.49304366
36PRKCB0.45367950
37CAMK10.45173565
38FLT30.43869915
39SGK10.42465756
40MELK0.41313617
41PKN20.40982517
42DYRK1A0.40287700
43NEK20.39106201
44SIK20.37678812
45PRKCA0.36751178
46PIK3CG0.34218558
47MAPK10.34187556
48PTK2B0.33493331
49TEC0.33332969
50CAMK40.32975234
51ABL10.31782410
52BRAF0.30925255
53OXSR10.30561112
54RPS6KA30.29535026
55CSNK1E0.29489512
56CSNK2A20.28594394
57MAPK30.28435490
58MOS0.28340100
59AKT10.27389841
60TXK0.26164326
61TGFBR20.23901153
62MAP2K20.23839986
63TIE10.23142000
64PRKACG0.22015155
65ZAK0.20040042
66WEE10.19533696
67PRKCH0.19280759
68STK390.18592819
69CSF1R0.17965903
70MARK30.17612731
71CSNK1A10.17521271
72PRKACA0.17079998
73NTRK20.16581300
74AURKB0.15996968
75MKNK20.15980534
76STK100.15741691
77PDK10.15703360
78CDC42BPA0.15664202
79WNK30.13443889
80GSK3B0.12778230
81PKN10.12536046
82ATM0.11845285
83MAPKAPK30.11542204
84EIF2AK20.11510204
85IGF1R0.11131741
86ATR0.10815553
87PRKG10.10488711
88ITK0.10044291
89KIT0.08991670
90CSNK1A1L0.08349517
91IKBKB0.08148382
92NME20.08079313
93BRSK20.07969444
94PAK60.07552872
95OBSCN0.06522020
96PRKAA10.06329050
97MAP2K10.06228405
98TRPM70.06081471
99CSNK2A10.05589863
100BLK0.05015061

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043204.46793952
2Cyanoamino acid metabolism_Homo sapiens_hsa004604.10940128
3Olfactory transduction_Homo sapiens_hsa047403.51083959
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.14381514
5Steroid hormone biosynthesis_Homo sapiens_hsa001403.13307931
6Sphingolipid metabolism_Homo sapiens_hsa006002.87928234
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.78754879
8ABC transporters_Homo sapiens_hsa020102.62394220
9Phototransduction_Homo sapiens_hsa047442.61617276
10Morphine addiction_Homo sapiens_hsa050322.47098911
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.39551169
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.39521370
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.38461027
14Pentose phosphate pathway_Homo sapiens_hsa000302.21723231
15Sulfur relay system_Homo sapiens_hsa041222.07529348
16Glycerolipid metabolism_Homo sapiens_hsa005611.92823657
17Ovarian steroidogenesis_Homo sapiens_hsa049131.86991394
18Fanconi anemia pathway_Homo sapiens_hsa034601.79152050
19Arachidonic acid metabolism_Homo sapiens_hsa005901.76758770
20Butanoate metabolism_Homo sapiens_hsa006501.59257096
21Linoleic acid metabolism_Homo sapiens_hsa005911.55143283
22Complement and coagulation cascades_Homo sapiens_hsa046101.53680687
23Taste transduction_Homo sapiens_hsa047421.53149302
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51948027
25Starch and sucrose metabolism_Homo sapiens_hsa005001.50418591
26Tryptophan metabolism_Homo sapiens_hsa003801.49365809
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41587416
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40323767
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32225621
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30388471
31Asthma_Homo sapiens_hsa053101.23374420
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21495771
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14963093
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13618201
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13474553
36Fatty acid degradation_Homo sapiens_hsa000711.11558574
37Retinol metabolism_Homo sapiens_hsa008301.10415412
38Graft-versus-host disease_Homo sapiens_hsa053321.07347796
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.07122329
40Estrogen signaling pathway_Homo sapiens_hsa049151.04763280
41Mineral absorption_Homo sapiens_hsa049781.04013409
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90500474
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90444603
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88522658
45Legionellosis_Homo sapiens_hsa051340.83375595
46Caffeine metabolism_Homo sapiens_hsa002320.82369083
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78106846
48Chemical carcinogenesis_Homo sapiens_hsa052040.75603763
49Nitrogen metabolism_Homo sapiens_hsa009100.74947782
50Salivary secretion_Homo sapiens_hsa049700.72819331
51Basal transcription factors_Homo sapiens_hsa030220.72564928
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72474559
53Calcium signaling pathway_Homo sapiens_hsa040200.72029373
54One carbon pool by folate_Homo sapiens_hsa006700.71278620
55Allograft rejection_Homo sapiens_hsa053300.67864755
56Glutathione metabolism_Homo sapiens_hsa004800.64994964
57Autoimmune thyroid disease_Homo sapiens_hsa053200.62849284
58Pancreatic secretion_Homo sapiens_hsa049720.62431953
59Ether lipid metabolism_Homo sapiens_hsa005650.60211735
60Staphylococcus aureus infection_Homo sapiens_hsa051500.59084504
61Histidine metabolism_Homo sapiens_hsa003400.57401648
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.56943057
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56381295
64MicroRNAs in cancer_Homo sapiens_hsa052060.54447134
65Glutamatergic synapse_Homo sapiens_hsa047240.52150281
66ECM-receptor interaction_Homo sapiens_hsa045120.50499537
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49263151
68mRNA surveillance pathway_Homo sapiens_hsa030150.48942771
69Arginine biosynthesis_Homo sapiens_hsa002200.48472974
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.48348721
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47576996
72Metabolic pathways_Homo sapiens_hsa011000.47503456
73Circadian entrainment_Homo sapiens_hsa047130.45822961
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.45439486
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44270030
76Homologous recombination_Homo sapiens_hsa034400.43898752
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42097859
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.39743936
79Serotonergic synapse_Homo sapiens_hsa047260.39108052
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38577223
81Lysosome_Homo sapiens_hsa041420.35536055
82Type I diabetes mellitus_Homo sapiens_hsa049400.35222251
83Hedgehog signaling pathway_Homo sapiens_hsa043400.34783385
84RNA degradation_Homo sapiens_hsa030180.32961300
85Protein digestion and absorption_Homo sapiens_hsa049740.32916312
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31170689
87Purine metabolism_Homo sapiens_hsa002300.28159159
88Nicotine addiction_Homo sapiens_hsa050330.21944019
89Oxytocin signaling pathway_Homo sapiens_hsa049210.20760867
90Basal cell carcinoma_Homo sapiens_hsa052170.19516137
91Base excision repair_Homo sapiens_hsa034100.19367261
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17839007
93Rheumatoid arthritis_Homo sapiens_hsa053230.17337797
94Glucagon signaling pathway_Homo sapiens_hsa049220.15843927
95Insulin secretion_Homo sapiens_hsa049110.15433313
96Peroxisome_Homo sapiens_hsa041460.14178687
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13994450
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.13360166
99Cardiac muscle contraction_Homo sapiens_hsa042600.12417893
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.10906059

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »