

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 9.40768524 |
| 2 | regulation of acrosome reaction (GO:0060046) | 8.63973241 |
| 3 | regulation of protein glycosylation (GO:0060049) | 8.13645883 |
| 4 | sphingosine metabolic process (GO:0006670) | 8.06146784 |
| 5 | positive regulation of cAMP-mediated signaling (GO:0043950) | 7.93715598 |
| 6 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 7.80737909 |
| 7 | diol metabolic process (GO:0034311) | 7.32374329 |
| 8 | piRNA metabolic process (GO:0034587) | 7.20574539 |
| 9 | thrombin receptor signaling pathway (GO:0070493) | 6.90752481 |
| 10 | sphingoid metabolic process (GO:0046519) | 6.82724544 |
| 11 | negative regulation of glycoprotein biosynthetic process (GO:0010561) | 6.64355870 |
| 12 | glycerol ether metabolic process (GO:0006662) | 6.55460641 |
| 13 | notochord development (GO:0030903) | 6.48150693 |
| 14 | ether metabolic process (GO:0018904) | 6.06357274 |
| 15 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 5.84207990 |
| 16 | cellular response to ammonium ion (GO:0071242) | 5.67226927 |
| 17 | regulation of glutamate receptor signaling pathway (GO:1900449) | 5.66207826 |
| 18 | DNA replication-dependent nucleosome organization (GO:0034723) | 5.44539546 |
| 19 | DNA replication-dependent nucleosome assembly (GO:0006335) | 5.44539546 |
| 20 | signal complex assembly (GO:0007172) | 5.42514385 |
| 21 | mRNA cleavage (GO:0006379) | 5.17811790 |
| 22 | regulation of cAMP-mediated signaling (GO:0043949) | 5.09880797 |
| 23 | ncRNA catabolic process (GO:0034661) | 5.03474258 |
| 24 | pyrimidine dimer repair (GO:0006290) | 4.97773081 |
| 25 | negative regulation of glycoprotein metabolic process (GO:1903019) | 4.97261251 |
| 26 | cellular response to alkaloid (GO:0071312) | 4.34722115 |
| 27 | negative regulation of cell-matrix adhesion (GO:0001953) | 4.30170560 |
| 28 | regulation of ER to Golgi vesicle-mediated transport (GO:0060628) | 4.24087997 |
| 29 | regulation of female receptivity (GO:0045924) | 4.14751516 |
| 30 | negative regulation of adenylate cyclase activity (GO:0007194) | 4.13462108 |
| 31 | regulation of translational elongation (GO:0006448) | 4.13174208 |
| 32 | glomerular visceral epithelial cell development (GO:0072015) | 4.01826586 |
| 33 | negative regulation of exocytosis (GO:0045920) | 3.98906483 |
| 34 | negative regulation of cyclase activity (GO:0031280) | 3.94137047 |
| 35 | vitamin catabolic process (GO:0009111) | 3.90521902 |
| 36 | fat-soluble vitamin catabolic process (GO:0042363) | 3.90521902 |
| 37 | N-terminal protein amino acid acetylation (GO:0006474) | 3.78557921 |
| 38 | cell-cell junction maintenance (GO:0045217) | 3.77210484 |
| 39 | glycosphingolipid metabolic process (GO:0006687) | 3.74045634 |
| 40 | negative regulation of lyase activity (GO:0051350) | 3.72350865 |
| 41 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.65732000 |
| 42 | coenzyme catabolic process (GO:0009109) | 3.65263836 |
| 43 | female mating behavior (GO:0060180) | 3.63538024 |
| 44 | response to morphine (GO:0043278) | 3.57669532 |
| 45 | glomerular epithelial cell development (GO:0072310) | 3.52142237 |
| 46 | cornea development in camera-type eye (GO:0061303) | 3.40481294 |
| 47 | response to isoquinoline alkaloid (GO:0014072) | 3.40375416 |
| 48 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.39994571 |
| 49 | omega-hydroxylase P450 pathway (GO:0097267) | 3.38749973 |
| 50 | wound healing, spreading of epidermal cells (GO:0035313) | 3.37482695 |
| 51 | chemical homeostasis within a tissue (GO:0048875) | 3.32101896 |
| 52 | regulation of odontogenesis (GO:0042481) | 3.29091307 |
| 53 | dopamine receptor signaling pathway (GO:0007212) | 3.27377255 |
| 54 | positive regulation of nitric oxide biosynthetic process (GO:0045429) | 3.25972271 |
| 55 | DNA synthesis involved in DNA repair (GO:0000731) | 3.24027766 |
| 56 | positive regulation of cardiac muscle cell differentiation (GO:2000727) | 3.22424870 |
| 57 | thyroid hormone generation (GO:0006590) | 3.19619290 |
| 58 | detection of chemical stimulus involved in sensory perception of smell (GO:0050911) | 3.18045772 |
| 59 | viral mRNA export from host cell nucleus (GO:0046784) | 3.16255657 |
| 60 | regulation of memory T cell differentiation (GO:0043380) | 3.10230825 |
| 61 | neuronal action potential (GO:0019228) | 3.08318384 |
| 62 | positive regulation of icosanoid secretion (GO:0032305) | 3.01341474 |
| 63 | glycolipid metabolic process (GO:0006664) | 3.01092253 |
| 64 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 3.00862635 |
| 65 | positive regulation of fatty acid transport (GO:2000193) | 2.99203960 |
| 66 | membrane lipid metabolic process (GO:0006643) | 2.98974901 |
| 67 | positive regulation of cholesterol efflux (GO:0010875) | 2.98655043 |
| 68 | positive regulation of protein complex disassembly (GO:0043243) | 2.96923965 |
| 69 | smooth muscle tissue development (GO:0048745) | 2.96669234 |
| 70 | left/right axis specification (GO:0070986) | 2.94893080 |
| 71 | membrane depolarization during action potential (GO:0086010) | 2.94668464 |
| 72 | surfactant homeostasis (GO:0043129) | 2.94453896 |
| 73 | negative regulation of cAMP biosynthetic process (GO:0030818) | 2.92878856 |
| 74 | regulation of cytokine production involved in inflammatory response (GO:1900015) | 2.88994998 |
| 75 | sensory perception of pain (GO:0019233) | 2.87603979 |
| 76 | cell junction maintenance (GO:0034331) | 2.87062888 |
| 77 | thyroid hormone metabolic process (GO:0042403) | 2.86574471 |
| 78 | response to caffeine (GO:0031000) | 2.82520635 |
| 79 | negative regulation of cyclic nucleotide biosynthetic process (GO:0030803) | 2.82153287 |
| 80 | liposaccharide metabolic process (GO:1903509) | 2.81886110 |
| 81 | polyol biosynthetic process (GO:0046173) | 2.80502191 |
| 82 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.74747862 |
| 83 | glomerular basement membrane development (GO:0032836) | 2.72876545 |
| 84 | positive regulation of sterol transport (GO:0032373) | 2.70989184 |
| 85 | positive regulation of cholesterol transport (GO:0032376) | 2.70989184 |
| 86 | ribonucleoprotein complex disassembly (GO:0032988) | 2.70975427 |
| 87 | glycerophospholipid catabolic process (GO:0046475) | 2.69901291 |
| 88 | regulation of glycoprotein biosynthetic process (GO:0010559) | 2.67029900 |
| 89 | negative regulation of nucleotide biosynthetic process (GO:0030809) | 2.65459631 |
| 90 | negative regulation of purine nucleotide biosynthetic process (GO:1900372) | 2.65459631 |
| 91 | protein localization to synapse (GO:0035418) | 2.64205747 |
| 92 | spermatid development (GO:0007286) | 2.63059937 |
| 93 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 16.3030404 |
| 94 | negative regulation of cAMP-mediated signaling (GO:0043951) | 13.6405979 |
| 95 | opioid receptor signaling pathway (GO:0038003) | 12.5203365 |
| 96 | ether lipid metabolic process (GO:0046485) | 11.4857832 |
| 97 | regulation of translational termination (GO:0006449) | 11.0457551 |
| 98 | behavioral response to ethanol (GO:0048149) | 11.0395962 |
| 99 | negative regulation of calcium ion-dependent exocytosis (GO:0045955) | 10.8153743 |
| 100 | adult feeding behavior (GO:0008343) | 10.3740763 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 4.49685342 |
| 2 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 4.29787758 |
| 3 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 4.09911385 |
| 4 | VDR_22108803_ChIP-Seq_LS180_Human | 3.95127382 |
| 5 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 3.37050466 |
| 6 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 3.37050466 |
| 7 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.18739274 |
| 8 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 3.18232714 |
| 9 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 3.03626731 |
| 10 | RXR_22108803_ChIP-Seq_LS180_Human | 2.90790394 |
| 11 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.81456951 |
| 12 | EGR1_19032775_ChIP-ChIP_M12_Human | 2.60768559 |
| 13 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.56046039 |
| 14 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.14475264 |
| 15 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.12686273 |
| 16 | HTT_18923047_ChIP-ChIP_STHdh_Human | 2.08476533 |
| 17 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 2.04102518 |
| 18 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.97806268 |
| 19 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.96912034 |
| 20 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.96100842 |
| 21 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.96100842 |
| 22 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.86092258 |
| 23 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.84572054 |
| 24 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.84431873 |
| 25 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.80695054 |
| 26 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.79934571 |
| 27 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.79934571 |
| 28 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.70067906 |
| 29 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.62736593 |
| 30 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.61168685 |
| 31 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.53406364 |
| 32 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.52224133 |
| 33 | TCF4_23295773_ChIP-Seq_U87_Human | 1.51210968 |
| 34 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.51151732 |
| 35 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.44745758 |
| 36 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.41017566 |
| 37 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.38735021 |
| 38 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.38445233 |
| 39 | STAT3_23295773_ChIP-Seq_U87_Human | 1.37843301 |
| 40 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.35577315 |
| 41 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.34885364 |
| 42 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.34130547 |
| 43 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.33453368 |
| 44 | SOX9_26525672_Chip-Seq_Limbbuds_Mouse | 1.31199685 |
| 45 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.29538504 |
| 46 | CDX2_22108803_ChIP-Seq_LS180_Human | 1.27299592 |
| 47 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.24970514 |
| 48 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.23712255 |
| 49 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 1.23234121 |
| 50 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.21224621 |
| 51 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.20718348 |
| 52 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.20406710 |
| 53 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.20044590 |
| 54 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.19900538 |
| 55 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.19298146 |
| 56 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.19148329 |
| 57 | CEBPB_22108803_ChIP-Seq_LS180_Human | 1.18947657 |
| 58 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.16724429 |
| 59 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.15497783 |
| 60 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.15205954 |
| 61 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.15025404 |
| 62 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.12700986 |
| 63 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.11704381 |
| 64 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.11010295 |
| 65 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 1.08173639 |
| 66 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.04581494 |
| 67 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.04514986 |
| 68 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.03303944 |
| 69 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.02850498 |
| 70 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.01853860 |
| 71 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 1.01641670 |
| 72 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.01626487 |
| 73 | P300_19829295_ChIP-Seq_ESCs_Human | 1.01281004 |
| 74 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.00631591 |
| 75 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.99515731 |
| 76 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.98851403 |
| 77 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.98247526 |
| 78 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 0.97968455 |
| 79 | TP53_16413492_ChIP-PET_HCT116_Human | 0.96998438 |
| 80 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.96924491 |
| 81 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 0.95602413 |
| 82 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.95465364 |
| 83 | AR_25329375_ChIP-Seq_VCAP_Human | 0.95065973 |
| 84 | GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.94369965 |
| 85 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.93810846 |
| 86 | OCT1_27270436_Chip-Seq_PROSTATE_Human | 0.93406779 |
| 87 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.92498368 |
| 88 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.92258086 |
| 89 | KDM2B_26808549_Chip-Seq_REH_Human | 0.90769882 |
| 90 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.89390444 |
| 91 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 0.89139851 |
| 92 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.88949927 |
| 93 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.87091480 |
| 94 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.86893380 |
| 95 | TP63_23658742_ChIP-Seq_EP156T_Human | 0.86005235 |
| 96 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.85873485 |
| 97 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.85798033 |
| 98 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.85357874 |
| 99 | GATA3_21867929_ChIP-Seq_TH1_Mouse | 0.84732622 |
| 100 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.83787285 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009278_abnormal_bone_marrow | 7.04243624 |
| 2 | MP0009780_abnormal_chondrocyte_physiolo | 6.55793688 |
| 3 | MP0002876_abnormal_thyroid_physiology | 5.67414516 |
| 4 | MP0005360_urolithiasis | 4.27054197 |
| 5 | MP0005503_abnormal_tendon_morphology | 4.19133867 |
| 6 | MP0001968_abnormal_touch/_nociception | 3.93765345 |
| 7 | MP0000678_abnormal_parathyroid_gland | 3.74861448 |
| 8 | MP0003941_abnormal_skin_development | 3.36837845 |
| 9 | MP0009764_decreased_sensitivity_to | 2.89908470 |
| 10 | MP0000681_abnormal_thyroid_gland | 2.73772734 |
| 11 | MP0003880_abnormal_central_pattern | 2.73154029 |
| 12 | MP0001545_abnormal_hematopoietic_system | 2.67365426 |
| 13 | MP0005397_hematopoietic_system_phenotyp | 2.67365426 |
| 14 | MP0009333_abnormal_splenocyte_physiolog | 2.30670547 |
| 15 | MP0001501_abnormal_sleep_pattern | 2.29111308 |
| 16 | MP0003045_fibrosis | 2.26926906 |
| 17 | MP0006035_abnormal_mitochondrial_morpho | 2.21391853 |
| 18 | MP0005646_abnormal_pituitary_gland | 2.20899197 |
| 19 | MP0003183_abnormal_peptide_metabolism | 2.19853740 |
| 20 | MP0001664_abnormal_digestion | 2.18781352 |
| 21 | MP0003191_abnormal_cellular_cholesterol | 2.04511219 |
| 22 | MP0005551_abnormal_eye_electrophysiolog | 2.02219181 |
| 23 | MP0003950_abnormal_plasma_membrane | 1.87755687 |
| 24 | MP0002249_abnormal_larynx_morphology | 1.87160941 |
| 25 | MP0010234_abnormal_vibrissa_follicle | 1.78269636 |
| 26 | MP0008057_abnormal_DNA_replication | 1.77854581 |
| 27 | MP0003633_abnormal_nervous_system | 1.72955437 |
| 28 | MP0002796_impaired_skin_barrier | 1.62119056 |
| 29 | MP0003879_abnormal_hair_cell | 1.61688215 |
| 30 | MP0003638_abnormal_response/metabolism_ | 1.52116623 |
| 31 | MP0003959_abnormal_lean_body | 1.50899779 |
| 32 | MP0004858_abnormal_nervous_system | 1.50391186 |
| 33 | MP0005645_abnormal_hypothalamus_physiol | 1.50213343 |
| 34 | MP0003195_calcinosis | 1.44553673 |
| 35 | MP0002733_abnormal_thermal_nociception | 1.41416914 |
| 36 | MP0009046_muscle_twitch | 1.30153554 |
| 37 | MP0002971_abnormal_brown_adipose | 1.24268678 |
| 38 | MP0003567_abnormal_fetal_cardiomyocyte | 1.22325734 |
| 39 | MP0003646_muscle_fatigue | 1.22182271 |
| 40 | MP0004782_abnormal_surfactant_physiolog | 1.18300315 |
| 41 | MP0009745_abnormal_behavioral_response | 1.16264135 |
| 42 | MP0001881_abnormal_mammary_gland | 1.14836422 |
| 43 | MP0002272_abnormal_nervous_system | 1.07628128 |
| 44 | MP0000015_abnormal_ear_pigmentation | 1.07242270 |
| 45 | MP0009765_abnormal_xenobiotic_induced | 1.03434000 |
| 46 | MP0004147_increased_porphyrin_level | 0.94883973 |
| 47 | MP0005501_abnormal_skin_physiology | 0.94715147 |
| 48 | MP0001270_distended_abdomen | 0.93115255 |
| 49 | MP0002148_abnormal_hypersensitivity_rea | 0.92867744 |
| 50 | MP0003631_nervous_system_phenotype | 0.92037809 |
| 51 | MP0000749_muscle_degeneration | 0.91619351 |
| 52 | MP0002168_other_aberrant_phenotype | 0.91316778 |
| 53 | MP0001486_abnormal_startle_reflex | 0.88435929 |
| 54 | MP0000230_abnormal_systemic_arterial | 0.86269393 |
| 55 | MP0005670_abnormal_white_adipose | 0.84567431 |
| 56 | MP0010771_integument_phenotype | 0.83955241 |
| 57 | MP0001970_abnormal_pain_threshold | 0.83519997 |
| 58 | MP0002693_abnormal_pancreas_physiology | 0.81345262 |
| 59 | MP0005334_abnormal_fat_pad | 0.77795497 |
| 60 | MP0002108_abnormal_muscle_morphology | 0.75412557 |
| 61 | MP0008775_abnormal_heart_ventricle | 0.74870502 |
| 62 | MP0008874_decreased_physiological_sensi | 0.74170297 |
| 63 | MP0005310_abnormal_salivary_gland | 0.73699133 |
| 64 | MP0003937_abnormal_limbs/digits/tail_de | 0.72623709 |
| 65 | MP0003868_abnormal_feces_composition | 0.70696574 |
| 66 | MP0009384_cardiac_valve_regurgitation | 0.70685856 |
| 67 | MP0004859_abnormal_synaptic_plasticity | 0.67994620 |
| 68 | MP0004264_abnormal_extraembryonic_tissu | 0.67533220 |
| 69 | MP0000049_abnormal_middle_ear | 0.67329442 |
| 70 | MP0004130_abnormal_muscle_cell | 0.67135635 |
| 71 | MP0005195_abnormal_posterior_eye | 0.65876031 |
| 72 | MP0005167_abnormal_blood-brain_barrier | 0.63505762 |
| 73 | MP0000358_abnormal_cell_content/ | 0.62252725 |
| 74 | MP0001919_abnormal_reproductive_system | 0.60798676 |
| 75 | MP0000569_abnormal_digit_pigmentation | 0.58120944 |
| 76 | MP0002229_neurodegeneration | 0.57126550 |
| 77 | MP0009672_abnormal_birth_weight | 0.56617945 |
| 78 | MP0008872_abnormal_physiological_respon | 0.56515919 |
| 79 | MP0006054_spinal_hemorrhage | 0.52459240 |
| 80 | MP0002557_abnormal_social/conspecific_i | 0.50948483 |
| 81 | MP0009053_abnormal_anal_canal | 0.50279325 |
| 82 | MP0004084_abnormal_cardiac_muscle | 0.47063887 |
| 83 | MP0005452_abnormal_adipose_tissue | 0.45996450 |
| 84 | MP0000685_abnormal_immune_system | 0.44588092 |
| 85 | MP0001324_abnormal_eye_pigmentation | 0.43536002 |
| 86 | MP0002069_abnormal_eating/drinking_beha | 0.43482662 |
| 87 | MP0003936_abnormal_reproductive_system | 0.42886114 |
| 88 | MP0002998_abnormal_bone_remodeling | 0.42425351 |
| 89 | MP0003635_abnormal_synaptic_transmissio | 0.42011384 |
| 90 | MP0009643_abnormal_urine_homeostasis | 0.41874745 |
| 91 | MP0002063_abnormal_learning/memory/cond | 0.41355219 |
| 92 | MP0004085_abnormal_heartbeat | 0.40852764 |
| 93 | MP0006072_abnormal_retinal_apoptosis | 0.39786256 |
| 94 | MP0002064_seizures | 0.39118404 |
| 95 | MP0000751_myopathy | 0.38895605 |
| 96 | MP0005390_skeleton_phenotype | 0.38798350 |
| 97 | MP0005369_muscle_phenotype | 0.37971750 |
| 98 | MP0001756_abnormal_urination | 0.37226565 |
| 99 | MP0010678_abnormal_skin_adnexa | 0.36338832 |
| 100 | MP0002067_abnormal_sensory_capabilities | 0.36070041 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Volvulus (HP:0002580) | 7.85865774 |
| 2 | Intestinal atresia (HP:0011100) | 7.10004650 |
| 3 | Abnormality of the aortic arch (HP:0012303) | 6.62675161 |
| 4 | Pancreatic islet-cell hyperplasia (HP:0004510) | 6.55719061 |
| 5 | Broad alveolar ridges (HP:0000187) | 6.15519697 |
| 6 | Thickened helices (HP:0000391) | 5.80245883 |
| 7 | Large for gestational age (HP:0001520) | 5.47559554 |
| 8 | Poor head control (HP:0002421) | 5.40535691 |
| 9 | Oligodontia (HP:0000677) | 5.25705211 |
| 10 | Agitation (HP:0000713) | 4.69183485 |
| 11 | Congenital ichthyosiform erythroderma (HP:0007431) | 4.65346734 |
| 12 | Focal motor seizures (HP:0011153) | 4.57264875 |
| 13 | Mesangial abnormality (HP:0001966) | 4.46147230 |
| 14 | Abnormality of endocrine pancreas physiology (HP:0012093) | 4.36859922 |
| 15 | Abnormality of the pancreatic islet cells (HP:0006476) | 4.36859922 |
| 16 | Gaze-evoked nystagmus (HP:0000640) | 4.09581360 |
| 17 | Abnormality of the ileum (HP:0001549) | 3.86895436 |
| 18 | Large eyes (HP:0001090) | 3.85607759 |
| 19 | Tented upper lip vermilion (HP:0010804) | 3.62575858 |
| 20 | Myositis (HP:0100614) | 3.56918332 |
| 21 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.50226458 |
| 22 | Gastrointestinal atresia (HP:0002589) | 3.41954845 |
| 23 | Tubular atrophy (HP:0000092) | 3.31667125 |
| 24 | Hypoproteinemia (HP:0003075) | 3.24694899 |
| 25 | Abnormality of the alveolar ridges (HP:0006477) | 3.13755716 |
| 26 | Hyperpituitarism (HP:0010514) | 3.11903434 |
| 27 | Chromsome breakage (HP:0040012) | 3.06936012 |
| 28 | Orchitis (HP:0100796) | 3.01956384 |
| 29 | Cerebellar dysplasia (HP:0007033) | 2.84552836 |
| 30 | Poor speech (HP:0002465) | 2.82882934 |
| 31 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.80790266 |
| 32 | Hyperthyroidism (HP:0000836) | 2.80481862 |
| 33 | Type II lissencephaly (HP:0007260) | 2.76949749 |
| 34 | Neonatal respiratory distress (HP:0002643) | 2.69181149 |
| 35 | Embryonal renal neoplasm (HP:0011794) | 2.64619652 |
| 36 | Ectropion (HP:0000656) | 2.61377570 |
| 37 | Optic nerve hypoplasia (HP:0000609) | 2.56447902 |
| 38 | Dialeptic seizures (HP:0011146) | 2.53462040 |
| 39 | Focal seizures (HP:0007359) | 2.52306792 |
| 40 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.47450037 |
| 41 | Nonprogressive disorder (HP:0003680) | 2.47359672 |
| 42 | Long nose (HP:0003189) | 2.47056355 |
| 43 | Broad-based gait (HP:0002136) | 2.46617276 |
| 44 | Restlessness (HP:0000711) | 2.38275207 |
| 45 | Hypoplasia of the brainstem (HP:0002365) | 2.38035847 |
| 46 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.38035847 |
| 47 | High anterior hairline (HP:0009890) | 2.36343867 |
| 48 | Striae distensae (HP:0001065) | 2.35835041 |
| 49 | Goiter (HP:0000853) | 2.28922869 |
| 50 | Entropion (HP:0000621) | 2.27429331 |
| 51 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.26811760 |
| 52 | Abnormality of macular pigmentation (HP:0008002) | 2.25607263 |
| 53 | Progressive inability to walk (HP:0002505) | 2.23899120 |
| 54 | Lissencephaly (HP:0001339) | 2.23229353 |
| 55 | Generalized tonic-clonic seizures (HP:0002069) | 2.22571636 |
| 56 | Pili torti (HP:0003777) | 2.22021740 |
| 57 | Abnormality of nail color (HP:0100643) | 2.15766731 |
| 58 | Impulsivity (HP:0100710) | 2.14242473 |
| 59 | Amelogenesis imperfecta (HP:0000705) | 2.12820545 |
| 60 | Keratoconus (HP:0000563) | 2.10934157 |
| 61 | Increased corneal curvature (HP:0100692) | 2.10934157 |
| 62 | Poikiloderma (HP:0001029) | 2.10619065 |
| 63 | Dysdiadochokinesis (HP:0002075) | 2.10569908 |
| 64 | Abnormality of the vitreous humor (HP:0004327) | 2.10565679 |
| 65 | Hypercortisolism (HP:0001578) | 2.04417543 |
| 66 | Abnormality of proline metabolism (HP:0010907) | 2.03183903 |
| 67 | Hydroxyprolinuria (HP:0003080) | 2.03183903 |
| 68 | Peritonitis (HP:0002586) | 2.01322105 |
| 69 | Thyroid-stimulating hormone excess (HP:0002925) | 14.9771061 |
| 70 | Hypohidrosis (HP:0000966) | 1.99477624 |
| 71 | Abnormal hair laboratory examination (HP:0003328) | 1.97296491 |
| 72 | Hypoplasia of the pons (HP:0012110) | 1.96502021 |
| 73 | Abnormality of the columella (HP:0009929) | 1.95864781 |
| 74 | Attenuation of retinal blood vessels (HP:0007843) | 1.95191296 |
| 75 | Muscular dystrophy (HP:0003560) | 1.93159132 |
| 76 | Pendular nystagmus (HP:0012043) | 1.93032393 |
| 77 | Ileus (HP:0002595) | 1.92224113 |
| 78 | Central scotoma (HP:0000603) | 1.89526357 |
| 79 | Congenital stationary night blindness (HP:0007642) | 1.86709836 |
| 80 | Testicular neoplasm (HP:0010788) | 1.84844502 |
| 81 | Autoimmune hemolytic anemia (HP:0001890) | 1.84000958 |
| 82 | Lack of skin elasticity (HP:0100679) | 1.82223120 |
| 83 | Hamartoma (HP:0010566) | 1.80881191 |
| 84 | Cutaneous melanoma (HP:0012056) | 1.79258886 |
| 85 | Abnormality of glycolipid metabolism (HP:0010969) | 1.78523869 |
| 86 | Abnormality of liposaccharide metabolism (HP:0010968) | 1.78523869 |
| 87 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 1.78523869 |
| 88 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.77083551 |
| 89 | Non-midline cleft lip (HP:0100335) | 1.75694754 |
| 90 | Scotoma (HP:0000575) | 1.75338736 |
| 91 | Abnormality of the pons (HP:0007361) | 1.70752592 |
| 92 | Episodic fever (HP:0001954) | 1.66538664 |
| 93 | Atonic seizures (HP:0010819) | 1.65983133 |
| 94 | Round face (HP:0000311) | 1.65959802 |
| 95 | Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318) | 1.64884842 |
| 96 | Neoplasm of the lung (HP:0100526) | 1.64821564 |
| 97 | Aplasia/Hypoplasia affecting the fundus (HP:0008057) | 1.62029800 |
| 98 | Severe visual impairment (HP:0001141) | 1.61894329 |
| 99 | 3-Methylglutaconic aciduria (HP:0003535) | 1.59906602 |
| 100 | Retrobulbar optic neuritis (HP:0100654) | 1.59330069 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ERN1 | 5.60909461 |
| 2 | FRK | 5.45940182 |
| 3 | PINK1 | 3.73774862 |
| 4 | IRAK3 | 3.29007758 |
| 5 | ADRBK1 | 2.95823279 |
| 6 | PNCK | 2.14678460 |
| 7 | IRAK1 | 2.02755094 |
| 8 | TYRO3 | 2.02400676 |
| 9 | ADRBK2 | 11.5724897 |
| 10 | PRKCG | 1.95865579 |
| 11 | RIPK1 | 1.83313658 |
| 12 | PRKCE | 1.73933562 |
| 13 | TGFBR1 | 1.72301071 |
| 14 | ACVR1B | 1.71911071 |
| 15 | DYRK3 | 1.70978739 |
| 16 | MAPK11 | 1.51842769 |
| 17 | CLK1 | 1.33335162 |
| 18 | PLK2 | 1.08978327 |
| 19 | GRK1 | 1.04432203 |
| 20 | NEK9 | 1.04213019 |
| 21 | BMPR1B | 0.99279854 |
| 22 | CAMK2A | 0.85917846 |
| 23 | PRKCI | 0.81073189 |
| 24 | CAMK1G | 0.79694696 |
| 25 | BRSK1 | 0.69530839 |
| 26 | ERBB2 | 0.64207213 |
| 27 | GRK7 | 0.62730697 |
| 28 | STK38L | 0.59097778 |
| 29 | EIF2AK3 | 0.58646592 |
| 30 | STK3 | 0.55753307 |
| 31 | MKNK1 | 0.54293036 |
| 32 | MAPKAPK5 | 0.53201174 |
| 33 | TAOK3 | 0.51635972 |
| 34 | STK38 | 0.49383862 |
| 35 | GRK5 | 0.49304366 |
| 36 | PRKCB | 0.45367950 |
| 37 | CAMK1 | 0.45173565 |
| 38 | FLT3 | 0.43869915 |
| 39 | SGK1 | 0.42465756 |
| 40 | MELK | 0.41313617 |
| 41 | PKN2 | 0.40982517 |
| 42 | DYRK1A | 0.40287700 |
| 43 | NEK2 | 0.39106201 |
| 44 | SIK2 | 0.37678812 |
| 45 | PRKCA | 0.36751178 |
| 46 | PIK3CG | 0.34218558 |
| 47 | MAPK1 | 0.34187556 |
| 48 | PTK2B | 0.33493331 |
| 49 | TEC | 0.33332969 |
| 50 | CAMK4 | 0.32975234 |
| 51 | ABL1 | 0.31782410 |
| 52 | BRAF | 0.30925255 |
| 53 | OXSR1 | 0.30561112 |
| 54 | RPS6KA3 | 0.29535026 |
| 55 | CSNK1E | 0.29489512 |
| 56 | CSNK2A2 | 0.28594394 |
| 57 | MAPK3 | 0.28435490 |
| 58 | MOS | 0.28340100 |
| 59 | AKT1 | 0.27389841 |
| 60 | TXK | 0.26164326 |
| 61 | TGFBR2 | 0.23901153 |
| 62 | MAP2K2 | 0.23839986 |
| 63 | TIE1 | 0.23142000 |
| 64 | PRKACG | 0.22015155 |
| 65 | ZAK | 0.20040042 |
| 66 | WEE1 | 0.19533696 |
| 67 | PRKCH | 0.19280759 |
| 68 | STK39 | 0.18592819 |
| 69 | CSF1R | 0.17965903 |
| 70 | MARK3 | 0.17612731 |
| 71 | CSNK1A1 | 0.17521271 |
| 72 | PRKACA | 0.17079998 |
| 73 | NTRK2 | 0.16581300 |
| 74 | AURKB | 0.15996968 |
| 75 | MKNK2 | 0.15980534 |
| 76 | STK10 | 0.15741691 |
| 77 | PDK1 | 0.15703360 |
| 78 | CDC42BPA | 0.15664202 |
| 79 | WNK3 | 0.13443889 |
| 80 | GSK3B | 0.12778230 |
| 81 | PKN1 | 0.12536046 |
| 82 | ATM | 0.11845285 |
| 83 | MAPKAPK3 | 0.11542204 |
| 84 | EIF2AK2 | 0.11510204 |
| 85 | IGF1R | 0.11131741 |
| 86 | ATR | 0.10815553 |
| 87 | PRKG1 | 0.10488711 |
| 88 | ITK | 0.10044291 |
| 89 | KIT | 0.08991670 |
| 90 | CSNK1A1L | 0.08349517 |
| 91 | IKBKB | 0.08148382 |
| 92 | NME2 | 0.08079313 |
| 93 | BRSK2 | 0.07969444 |
| 94 | PAK6 | 0.07552872 |
| 95 | OBSCN | 0.06522020 |
| 96 | PRKAA1 | 0.06329050 |
| 97 | MAP2K1 | 0.06228405 |
| 98 | TRPM7 | 0.06081471 |
| 99 | CSNK2A1 | 0.05589863 |
| 100 | BLK | 0.05015061 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 4.46793952 |
| 2 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 4.10940128 |
| 3 | Olfactory transduction_Homo sapiens_hsa04740 | 3.51083959 |
| 4 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 3.14381514 |
| 5 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 3.13307931 |
| 6 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 2.87928234 |
| 7 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.78754879 |
| 8 | ABC transporters_Homo sapiens_hsa02010 | 2.62394220 |
| 9 | Phototransduction_Homo sapiens_hsa04744 | 2.61617276 |
| 10 | Morphine addiction_Homo sapiens_hsa05032 | 2.47098911 |
| 11 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.39551169 |
| 12 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 2.39521370 |
| 13 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 2.38461027 |
| 14 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 2.21723231 |
| 15 | Sulfur relay system_Homo sapiens_hsa04122 | 2.07529348 |
| 16 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.92823657 |
| 17 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 1.86991394 |
| 18 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.79152050 |
| 19 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.76758770 |
| 20 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.59257096 |
| 21 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.55143283 |
| 22 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.53680687 |
| 23 | Taste transduction_Homo sapiens_hsa04742 | 1.53149302 |
| 24 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.51948027 |
| 25 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.50418591 |
| 26 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.49365809 |
| 27 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.41587416 |
| 28 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.40323767 |
| 29 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.32225621 |
| 30 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.30388471 |
| 31 | Asthma_Homo sapiens_hsa05310 | 1.23374420 |
| 32 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.21495771 |
| 33 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.14963093 |
| 34 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.13618201 |
| 35 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.13474553 |
| 36 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.11558574 |
| 37 | Retinol metabolism_Homo sapiens_hsa00830 | 1.10415412 |
| 38 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.07347796 |
| 39 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.07122329 |
| 40 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.04763280 |
| 41 | Mineral absorption_Homo sapiens_hsa04978 | 1.04013409 |
| 42 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.90500474 |
| 43 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.90444603 |
| 44 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.88522658 |
| 45 | Legionellosis_Homo sapiens_hsa05134 | 0.83375595 |
| 46 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.82369083 |
| 47 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.78106846 |
| 48 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.75603763 |
| 49 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.74947782 |
| 50 | Salivary secretion_Homo sapiens_hsa04970 | 0.72819331 |
| 51 | Basal transcription factors_Homo sapiens_hsa03022 | 0.72564928 |
| 52 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.72474559 |
| 53 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.72029373 |
| 54 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.71278620 |
| 55 | Allograft rejection_Homo sapiens_hsa05330 | 0.67864755 |
| 56 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.64994964 |
| 57 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.62849284 |
| 58 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.62431953 |
| 59 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.60211735 |
| 60 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.59084504 |
| 61 | Histidine metabolism_Homo sapiens_hsa00340 | 0.57401648 |
| 62 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.56943057 |
| 63 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.56381295 |
| 64 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.54447134 |
| 65 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.52150281 |
| 66 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.50499537 |
| 67 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.49263151 |
| 68 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.48942771 |
| 69 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.48472974 |
| 70 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.48348721 |
| 71 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.47576996 |
| 72 | Metabolic pathways_Homo sapiens_hsa01100 | 0.47503456 |
| 73 | Circadian entrainment_Homo sapiens_hsa04713 | 0.45822961 |
| 74 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.45439486 |
| 75 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.44270030 |
| 76 | Homologous recombination_Homo sapiens_hsa03440 | 0.43898752 |
| 77 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.42097859 |
| 78 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.39743936 |
| 79 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.39108052 |
| 80 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.38577223 |
| 81 | Lysosome_Homo sapiens_hsa04142 | 0.35536055 |
| 82 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.35222251 |
| 83 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.34783385 |
| 84 | RNA degradation_Homo sapiens_hsa03018 | 0.32961300 |
| 85 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.32916312 |
| 86 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.31170689 |
| 87 | Purine metabolism_Homo sapiens_hsa00230 | 0.28159159 |
| 88 | Nicotine addiction_Homo sapiens_hsa05033 | 0.21944019 |
| 89 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.20760867 |
| 90 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.19516137 |
| 91 | Base excision repair_Homo sapiens_hsa03410 | 0.19367261 |
| 92 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.17839007 |
| 93 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.17337797 |
| 94 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.15843927 |
| 95 | Insulin secretion_Homo sapiens_hsa04911 | 0.15433313 |
| 96 | Peroxisome_Homo sapiens_hsa04146 | 0.14178687 |
| 97 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.13994450 |
| 98 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.13360166 |
| 99 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.12417893 |
| 100 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.10906059 |

