PSMB10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.11953754
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.11953754
3antigen processing and presentation of endogenous antigen (GO:0019883)5.92785912
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.99477402
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.59845432
6negative regulation of cell killing (GO:0031342)4.59845432
7cellular response to type I interferon (GO:0071357)4.44358857
8type I interferon signaling pathway (GO:0060337)4.44358857
9response to type I interferon (GO:0034340)4.44219418
10response to interferon-beta (GO:0035456)4.29200736
11positive thymic T cell selection (GO:0045059)4.27676720
12cellular response to interferon-beta (GO:0035458)4.19388006
13ribosomal small subunit assembly (GO:0000028)4.12208199
14regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.08602050
15positive regulation of gamma-delta T cell activation (GO:0046645)4.08586202
16immunoglobulin mediated immune response (GO:0016064)3.98393393
17positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.86789657
18positive regulation of antigen processing and presentation (GO:0002579)3.76417010
19detection of bacterium (GO:0016045)3.75151806
20positive regulation of interferon-alpha production (GO:0032727)3.68893884
21detection of other organism (GO:0098543)3.61590686
22positive T cell selection (GO:0043368)3.52607604
23interferon-gamma-mediated signaling pathway (GO:0060333)3.50458756
24neutrophil activation involved in immune response (GO:0002283)3.49989126
25cellular response to zinc ion (GO:0071294)3.49447048
26cytidine deamination (GO:0009972)3.48143161
27cytidine metabolic process (GO:0046087)3.48143161
28cytidine catabolic process (GO:0006216)3.48143161
29regulation of interferon-alpha production (GO:0032647)3.46376422
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.40976638
31defense response to protozoan (GO:0042832)3.40355202
32negative regulation of interleukin-12 production (GO:0032695)3.40037511
33antigen processing and presentation via MHC class Ib (GO:0002475)3.39520571
34B cell mediated immunity (GO:0019724)3.38362197
35regulation of antigen processing and presentation (GO:0002577)3.33884969
36DNA deamination (GO:0045006)3.33871222
37response to interferon-alpha (GO:0035455)3.31933523
38respiratory burst (GO:0045730)3.28143250
39NIK/NF-kappaB signaling (GO:0038061)3.27303983
40viral transcription (GO:0019083)3.19992911
41Arp2/3 complex-mediated actin nucleation (GO:0034314)3.19871647
42myeloid dendritic cell activation (GO:0001773)3.18906353
43purine deoxyribonucleotide catabolic process (GO:0009155)3.17321467
44positive regulation of T cell mediated cytotoxicity (GO:0001916)3.16338354
45thymic T cell selection (GO:0045061)3.16171541
46regulation of T cell mediated cytotoxicity (GO:0001914)3.14931317
47regulation of B cell receptor signaling pathway (GO:0050855)3.14318895
48cellular response to interleukin-15 (GO:0071350)3.14054220
49cellular response to exogenous dsRNA (GO:0071360)3.12625017
50T cell migration (GO:0072678)3.12360000
51T cell selection (GO:0045058)3.09300289
52regulation of interferon-beta biosynthetic process (GO:0045357)3.08855202
53negative regulation of viral genome replication (GO:0045071)3.08749529
54regulation of type I interferon-mediated signaling pathway (GO:0060338)3.08658077
55response to peptidoglycan (GO:0032494)3.08102589
56response to protozoan (GO:0001562)3.07549267
57mature B cell differentiation involved in immune response (GO:0002313)3.06349048
58response to interleukin-15 (GO:0070672)3.05763395
59regulation of RIG-I signaling pathway (GO:0039535)3.02981583
60sequestering of actin monomers (GO:0042989)3.02869134
61translational termination (GO:0006415)3.02504312
62myeloid dendritic cell differentiation (GO:0043011)3.00929032
63pyrimidine ribonucleoside catabolic process (GO:0046133)3.00031145
64regulation of gamma-delta T cell differentiation (GO:0045586)2.97944369
65negative regulation of B cell apoptotic process (GO:0002903)2.96722504
66regulation of response to interferon-gamma (GO:0060330)2.93462988
67modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.90525241
68positive regulation by organism of defense response of other organism involved in symbiotic interact2.90525241
69modulation by symbiont of host immune response (GO:0052553)2.90525241
70positive regulation by symbiont of host defense response (GO:0052509)2.90525241
71modulation by symbiont of host defense response (GO:0052031)2.90525241
72modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.90525241
73regulation of T cell tolerance induction (GO:0002664)2.90095467
74regulation of gamma-delta T cell activation (GO:0046643)2.88920913
75negative regulation of lymphocyte mediated immunity (GO:0002707)2.88438393
76negative regulation of leukocyte mediated immunity (GO:0002704)2.86505985
77actin nucleation (GO:0045010)2.86396957
78leukocyte aggregation (GO:0070486)2.85797965
79negative regulation of myeloid cell apoptotic process (GO:0033033)2.85554899
80SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.85043746
81macrophage activation involved in immune response (GO:0002281)2.84834086
82* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.84521684
83negative regulation of innate immune response (GO:0045824)2.82637656
84positive regulation of B cell differentiation (GO:0045579)2.82027157
85regulation of dendritic cell antigen processing and presentation (GO:0002604)2.80515625
86T cell costimulation (GO:0031295)2.80345233
87lipopolysaccharide-mediated signaling pathway (GO:0031663)2.79592698
88ribosomal small subunit biogenesis (GO:0042274)2.79347543
89positive regulation of natural killer cell differentiation (GO:0032825)2.78367418
90regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.78271084
91regulation of natural killer cell mediated immunity (GO:0002715)2.78271084
92lymphocyte costimulation (GO:0031294)2.76534883
93regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.76499592
94cotranslational protein targeting to membrane (GO:0006613)2.76151032
95protein targeting to ER (GO:0045047)2.75947199
96negative regulation of T cell mediated immunity (GO:0002710)2.75661479
97regulation of T-helper 1 cell differentiation (GO:0045625)2.74538589
98regulation of interleukin-12 biosynthetic process (GO:0045075)2.74379722
99cellular response to interferon-gamma (GO:0071346)2.74180849
100* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.73985584
101regulation of regulatory T cell differentiation (GO:0045589)2.73615151
102detection of external biotic stimulus (GO:0098581)2.73296425
103leukocyte degranulation (GO:0043299)2.71930840
104regulation of leukocyte mediated cytotoxicity (GO:0001910)2.70871456
105Peyers patch development (GO:0048541)2.70352195
106mucosal-associated lymphoid tissue development (GO:0048537)2.70352195
107regulation of B cell apoptotic process (GO:0002902)2.68950644
108positive regulation of lymphocyte migration (GO:2000403)2.68873566
109regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.68464448
110translational elongation (GO:0006414)2.67519404
111positive regulation of interferon-beta production (GO:0032728)2.67500414
112antigen receptor-mediated signaling pathway (GO:0050851)2.67279018
113mast cell activation (GO:0045576)2.66852828
114regulation of B cell differentiation (GO:0045577)2.66250753
115regulation of tolerance induction (GO:0002643)2.66132281
116positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.65658283
117negative thymic T cell selection (GO:0045060)2.64232376
118protein localization to endoplasmic reticulum (GO:0070972)2.63593836
119dendritic cell differentiation (GO:0097028)2.63314643
120lymphocyte chemotaxis (GO:0048247)2.62933118
121response to interferon-gamma (GO:0034341)2.61951206
122negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.61648570
123negative regulation of leukocyte apoptotic process (GO:2000107)2.61488522
124natural killer cell mediated immunity (GO:0002228)2.59706976
125natural killer cell mediated cytotoxicity (GO:0042267)2.59706976
126neutrophil activation (GO:0042119)2.59108275
127establishment of protein localization to endoplasmic reticulum (GO:0072599)2.58971552
128negative T cell selection (GO:0043383)2.58328656
129regulation of chemokine biosynthetic process (GO:0045073)2.57563376
130cellular response to virus (GO:0098586)2.57419084
131regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.57127626
132positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.54654574
133regulation of alpha-beta T cell proliferation (GO:0046640)2.53733655
134regulation of T cell receptor signaling pathway (GO:0050856)2.53317161
135granulocyte activation (GO:0036230)2.52803878
136leukocyte mediated cytotoxicity (GO:0001909)2.49348295
137myeloid cell activation involved in immune response (GO:0002275)2.48282633
138regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.48070852
139positive regulation of chemokine biosynthetic process (GO:0045080)2.46644623
140defense response to virus (GO:0051607)2.46230686
141B cell receptor signaling pathway (GO:0050853)2.45744695
142positive regulation of interleukin-12 production (GO:0032735)2.45635042
143positive regulation of alpha-beta T cell proliferation (GO:0046641)2.45359361
144natural killer cell activation (GO:0030101)2.44913590
145reactive oxygen species biosynthetic process (GO:1903409)2.43446084

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human5.81724457
2* IRF8_21731497_ChIP-ChIP_J774_Mouse4.44519914
3* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.16636253
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.98903752
5SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.94354310
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.93683336
7E2F7_22180533_ChIP-Seq_HELA_Human2.90323648
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.87629684
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.79567452
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.70338068
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.55612125
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.45315149
13* IRF8_27001747_Chip-Seq_BMDM_Mouse2.44579761
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.38592430
15* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.37086644
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.35639174
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18564256
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15836911
19* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12579358
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.10865600
21SPI1_23547873_ChIP-Seq_NB4_Human2.10668394
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10615661
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09731312
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.95772282
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95278898
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89574422
27MYB_26560356_Chip-Seq_TH2_Human1.81480103
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.79324297
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.78139887
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.76400096
31VDR_21846776_ChIP-Seq_THP-1_Human1.74731970
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73995722
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.73624027
34MAF_26560356_Chip-Seq_TH1_Human1.71742354
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70240822
36* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60905386
37CIITA_25753668_ChIP-Seq_RAJI_Human1.60836828
38MYC_22102868_ChIP-Seq_BL_Human1.60118582
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60031563
40GATA1_22025678_ChIP-Seq_K562_Human1.59244689
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.59033932
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.56936711
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55946270
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55762352
45SCL_19346495_ChIP-Seq_HPC-7_Human1.54058639
46MYB_26560356_Chip-Seq_TH1_Human1.53974947
47* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.53431976
48* VDR_23849224_ChIP-Seq_CD4+_Human1.52484383
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.50280753
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.47700200
51VDR_24763502_ChIP-Seq_THP-1_Human1.47171631
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46528380
53ELF1_20517297_ChIP-Seq_JURKAT_Human1.46222815
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45852070
55* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45690650
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45085643
57LXR_22292898_ChIP-Seq_THP-1_Human1.44149436
58BCOR_27268052_Chip-Seq_Bcells_Human1.43972161
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40847563
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39101983
61* UTX_26944678_Chip-Seq_JUKART_Human1.38295487
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.37637774
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37607936
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36504471
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35940496
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33318585
67* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.33030656
68FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.31617894
69GATA3_26560356_Chip-Seq_TH2_Human1.31199932
70RUNX_20019798_ChIP-Seq_JUKART_Human1.28259091
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27955127
72* MAF_26560356_Chip-Seq_TH2_Human1.27414519
73FOXP3_21729870_ChIP-Seq_TREG_Human1.26618463
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26523729
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26499919
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23928505
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22321173
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20287004
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19755841
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17565320
81* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17465439
82DCP1A_22483619_ChIP-Seq_HELA_Human1.15742239
83CTCF_26484167_Chip-Seq_Bcells_Mouse1.15402088
84CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13517086
85P68_20966046_ChIP-Seq_HELA_Human1.13199424
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13009412
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12783152
88XRN2_22483619_ChIP-Seq_HELA_Human1.10126577
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09680911
90P300_27268052_Chip-Seq_Bcells_Human1.09448009
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09058203
92E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07823964
93* ELK3_25401928_ChIP-Seq_HUVEC_Human1.07648262
94* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.07283432
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06545643
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06204170
97CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05894892
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04259690
99SPI1_23127762_ChIP-Seq_K562_Human1.03420160
100SPI1_20517297_ChIP-Seq_HL60_Human1.03392194
101YY1_22570637_ChIP-Seq_MALME-3M_Human1.02958927
102E2F1_20622854_ChIP-Seq_HELA_Human1.02911413
103HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02829670
104MYC_19079543_ChIP-ChIP_MESCs_Mouse1.02791005
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02766415
106STAT1_20625510_ChIP-Seq_HELA_Human1.02693367
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02674868
108GATA3_27048872_Chip-Seq_THYMUS_Human1.01751178
109TCF7_22412390_ChIP-Seq_EML_Mouse1.01120902
110PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00747467
111PU_27001747_Chip-Seq_BMDM_Mouse1.00318751
112PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99595024
113SA1_27219007_Chip-Seq_ERYTHROID_Human0.99486324
114SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98663713
115KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98257268
116TET1_21451524_ChIP-Seq_MESCs_Mouse0.97658349
117RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97365066
118GABP_19822575_ChIP-Seq_HepG2_Human0.97151866
119KDM2B_26808549_Chip-Seq_DND41_Human0.96903069
120BCL6_27268052_Chip-Seq_Bcells_Human0.96808831
121GATA1_19941827_ChIP-Seq_MEL_Mouse0.96670780
122Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96203395
123PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95832226
124SA1_27219007_Chip-Seq_Bcells_Human0.95725852
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95600677
126* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95291175
127CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95019654
128YY1_21170310_ChIP-Seq_MESCs_Mouse0.93593524

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.89351869
2MP0009785_altered_susceptibility_to3.83105505
3MP0005671_abnormal_response_to3.56203102
4MP0000685_abnormal_immune_system3.52672594
5MP0005025_abnormal_response_to3.00852373
6MP0002148_abnormal_hypersensitivity_rea3.00539154
7MP0003724_increased_susceptibility_to2.94818000
8MP0003436_decreased_susceptibility_to2.89938585
9MP0001790_abnormal_immune_system2.89404980
10MP0005387_immune_system_phenotype2.89404980
11MP0005000_abnormal_immune_tolerance2.86558206
12MP0001800_abnormal_humoral_immune2.78471386
13MP0006082_CNS_inflammation2.66535550
14MP0002723_abnormal_immune_serum2.56820417
15MP0002452_abnormal_antigen_presenting2.56650367
16MP0003763_abnormal_thymus_physiology2.54725551
17MP0002419_abnormal_innate_immunity2.51125120
18* MP0001819_abnormal_immune_cell2.41799112
19* MP0002420_abnormal_adaptive_immunity2.41203084
20MP0003806_abnormal_nucleotide_metabolis2.39253525
21MP0002166_altered_tumor_susceptibility2.30916692
22MP0001853_heart_inflammation2.19469927
23MP0001873_stomach_inflammation2.16524930
24MP0010155_abnormal_intestine_physiology2.14659842
25MP0004510_myositis2.13646576
26MP0009333_abnormal_splenocyte_physiolog2.07386317
27MP0002006_tumorigenesis2.06630274
28* MP0002398_abnormal_bone_marrow2.00484184
29MP0001845_abnormal_inflammatory_respons1.96064375
30* MP0000716_abnormal_immune_system1.95464810
31MP0002405_respiratory_system_inflammati1.93954835
32MP0005464_abnormal_platelet_physiology1.90047683
33MP0008469_abnormal_protein_level1.78336619
34MP0000689_abnormal_spleen_morphology1.71553612
35MP0002722_abnormal_immune_system1.67427382
36MP0004947_skin_inflammation1.67411883
37* MP0002429_abnormal_blood_cell1.66647844
38MP0003191_abnormal_cellular_cholesterol1.66015498
39MP0003303_peritoneal_inflammation1.65821699
40MP0002396_abnormal_hematopoietic_system1.65086746
41MP0005310_abnormal_salivary_gland1.56947628
42MP0003866_abnormal_defecation1.47225641
43MP0009764_decreased_sensitivity_to1.44151237
44MP0001533_abnormal_skeleton_physiology1.43693701
45MP0003186_abnormal_redox_activity1.43466087
46MP0005058_abnormal_lysosome_morphology1.39210707
47MP0000490_abnormal_crypts_of1.35903811
48MP0002138_abnormal_hepatobiliary_system1.33129553
49MP0000858_altered_metastatic_potential1.32836626
50MP0003183_abnormal_peptide_metabolism1.29501670
51MP0009840_abnormal_foam_cell1.27714594
52MP0001545_abnormal_hematopoietic_system1.26630294
53MP0005397_hematopoietic_system_phenotyp1.26630294
54MP0000343_altered_response_to1.24768929
55MP0000703_abnormal_thymus_morphology1.20029305
56MP0005083_abnormal_biliary_tract1.19888798
57MP0002254_reproductive_system_inflammat1.18257089
58MP0001666_abnormal_nutrient_absorption1.14811329
59MP0003448_altered_tumor_morphology1.11642249
60MP0001764_abnormal_homeostasis1.07376968
61MP0001663_abnormal_digestive_system1.05296751
62MP0009763_increased_sensitivity_to1.02736351
63MP0008260_abnormal_autophagy1.01887022
64MP0004782_abnormal_surfactant_physiolog1.01403072
65MP0004808_abnormal_hematopoietic_stem1.01145327
66MP0005360_urolithiasis0.98568299
67MP0003693_abnormal_embryo_hatching0.95498113
68MP0003172_abnormal_lysosome_physiology0.94229795
69MP0003300_gastrointestinal_ulcer0.93353468
70MP0003075_altered_response_to0.90502307
71MP0005174_abnormal_tail_pigmentation0.88529714
72MP0002139_abnormal_hepatobiliary_system0.87978214
73MP0002933_joint_inflammation0.87751526
74MP0000604_amyloidosis0.87179883
75MP0001348_abnormal_lacrimal_gland0.86138595
76MP0005166_decreased_susceptibility_to0.85916382
77MP0005451_abnormal_body_composition0.84772397
78MP0000465_gastrointestinal_hemorrhage0.84744867
79MP0002277_abnormal_respiratory_mucosa0.83286845
80MP0002019_abnormal_tumor_incidence0.82706835
81MP0005319_abnormal_enzyme/_coenzyme0.82355840
82MP0009379_abnormal_foot_pigmentation0.82016588
83MP0005365_abnormal_bile_salt0.79821855
84MP0002132_abnormal_respiratory_system0.78835216
85MP0005075_abnormal_melanosome_morpholog0.78128654
86MP0002693_abnormal_pancreas_physiology0.76611785
87MP0001986_abnormal_taste_sensitivity0.75205708
88MP0006036_abnormal_mitochondrial_physio0.73276789
89MP0009643_abnormal_urine_homeostasis0.72643850
90MP0005584_abnormal_enzyme/coenzyme_acti0.72168680
91MP0000609_abnormal_liver_physiology0.70756416
92MP0005390_skeleton_phenotype0.70741289
93MP0009278_abnormal_bone_marrow0.68758967
94MP0010307_abnormal_tumor_latency0.67375804
95MP0002876_abnormal_thyroid_physiology0.67010307
96MP0003656_abnormal_erythrocyte_physiolo0.66782851
97MP0009765_abnormal_xenobiotic_induced0.66587711
98MP0002998_abnormal_bone_remodeling0.65888339
99MP0002136_abnormal_kidney_physiology0.64646600
100MP0004883_abnormal_blood_vessel0.64601307
101MP0001851_eye_inflammation0.63735146
102MP0005084_abnormal_gallbladder_morpholo0.62801842
103MP0003828_pulmonary_edema0.61621345
104MP0000249_abnormal_blood_vessel0.61043601
105MP0005085_abnormal_gallbladder_physiolo0.60667680
106MP0000598_abnormal_liver_morphology0.60624887
107MP0008873_increased_physiological_sensi0.59099518
108MP0004381_abnormal_hair_follicle0.58483034
109MP0000015_abnormal_ear_pigmentation0.56945335
110MP0003638_abnormal_response/metabolism_0.56739489
111MP0008874_decreased_physiological_sensi0.56461785
112MP0005165_increased_susceptibility_to0.56234712
113MP0003045_fibrosis0.56044755
114MP0008875_abnormal_xenobiotic_pharmacok0.54478531
115MP0003795_abnormal_bone_structure0.52180276
116MP0005381_digestive/alimentary_phenotyp0.51212955
117MP0008004_abnormal_stomach_pH0.49262929
118MP0005164_abnormal_response_to0.49113249
119MP0005535_abnormal_body_temperature0.48212473

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.30465917
2Recurrent abscess formation (HP:0002722)4.88765220
3Eczematoid dermatitis (HP:0000976)4.73471229
4Recurrent bacterial skin infections (HP:0005406)4.46914848
5Chronic otitis media (HP:0000389)4.11822475
6Myositis (HP:0100614)3.89200202
7Recurrent bronchitis (HP:0002837)3.77439903
8Recurrent fungal infections (HP:0002841)3.77194984
9Recurrent cutaneous fungal infections (HP:0011370)3.69070823
10Chronic mucocutaneous candidiasis (HP:0002728)3.69070823
11Autoimmune thrombocytopenia (HP:0001973)3.58318891
12Recurrent gram-negative bacterial infections (HP:0005420)3.54661599
13Recurrent skin infections (HP:0001581)3.52856488
14Recurrent viral infections (HP:0004429)3.39109258
15Abnormality of macrophages (HP:0004311)3.37920693
16Mediastinal lymphadenopathy (HP:0100721)3.33227759
17Increased IgM level (HP:0003496)3.32268159
18IgM deficiency (HP:0002850)3.31283448
19Thrombocytosis (HP:0001894)3.30102485
20Nasal polyposis (HP:0100582)3.16065496
21Abnormality of T cell number (HP:0011839)3.15607272
22Abnormality of T cells (HP:0002843)3.10363270
23Abnormality of the nasal mucosa (HP:0000433)3.10249199
24Petechiae (HP:0000967)3.06748130
25Pustule (HP:0200039)3.02225368
26Vasculitis (HP:0002633)3.01263600
27T lymphocytopenia (HP:0005403)3.00388607
28Abnormality of T cell physiology (HP:0011840)2.94218834
29Orchitis (HP:0100796)2.93026528
30Agammaglobulinemia (HP:0004432)2.87478330
31Hypergammaglobulinemia (HP:0010702)2.84540230
32Chronic obstructive pulmonary disease (HP:0006510)2.82944768
33Obstructive lung disease (HP:0006536)2.82944768
34Meningitis (HP:0001287)2.81032381
35Vacuolated lymphocytes (HP:0001922)2.80472852
36Interstitial pulmonary disease (HP:0006530)2.78111712
37Abnormality of cells of the erythroid lineage (HP:0012130)2.74741632
38IgG deficiency (HP:0004315)2.72791093
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.71025429
40Gastrointestinal infarctions (HP:0005244)2.66390528
41Abnormal number of erythroid precursors (HP:0012131)2.65892825
42Basal ganglia calcification (HP:0002135)2.64900644
43Gingivitis (HP:0000230)2.64225084
44Combined immunodeficiency (HP:0005387)2.62639143
45Stomatitis (HP:0010280)2.61357384
46Severe combined immunodeficiency (HP:0004430)2.61134994
47Urticaria (HP:0001025)2.60320469
48Abnormality of the prostate (HP:0008775)2.58518793
49Autoimmune hemolytic anemia (HP:0001890)2.57881041
50Systemic lupus erythematosus (HP:0002725)2.57407220
51Abnormality of liposaccharide metabolism (HP:0010968)2.55411131
52Abnormality of glycosphingolipid metabolism (HP:0004343)2.55411131
53Abnormality of glycolipid metabolism (HP:0010969)2.55411131
54Abnormality of cells of the lymphoid lineage (HP:0012140)2.51793983
55Chronic sinusitis (HP:0011109)2.50499882
56Optic neuritis (HP:0100653)2.50401647
57Retrobulbar optic neuritis (HP:0100654)2.50401647
58Lymphopenia (HP:0001888)2.50354146
59Chest pain (HP:0100749)2.48877062
60Cellulitis (HP:0100658)2.48559699
61Periodontitis (HP:0000704)2.46792317
62Panhypogammaglobulinemia (HP:0003139)2.45157291
63Recurrent sinusitis (HP:0011108)2.42252589
64Keratoconjunctivitis sicca (HP:0001097)2.39059448
65Inflammation of the large intestine (HP:0002037)2.37228855
66Hepatosplenomegaly (HP:0001433)2.36451537
67Granulocytopenia (HP:0001913)2.32812630
68Gastrointestinal inflammation (HP:0004386)2.32154278
69Leukocytosis (HP:0001974)2.31675115
70Increased cerebral lipofuscin (HP:0011813)2.30808896
71Abnormality of eosinophils (HP:0001879)2.28820538
72Abnormality of the pleura (HP:0002103)2.26827532
73Chronic diarrhea (HP:0002028)2.26421256
74Spontaneous hematomas (HP:0007420)2.26151334
75Purpura (HP:0000979)2.25966991
76Pulmonary infiltrates (HP:0002113)2.25789902
77Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.25777777
78Decreased activity of mitochondrial respiratory chain (HP:0008972)2.25777777
79Hemoptysis (HP:0002105)2.25617769
80Eosinophilia (HP:0001880)2.23732668
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.23515066
82Reticulocytopenia (HP:0001896)2.23347753
83Hypoplasia of the thymus (HP:0000778)2.22653387
84Gastrointestinal stroma tumor (HP:0100723)2.21220303
85Thyroiditis (HP:0100646)2.20470232
86Hypertensive crisis (HP:0100735)2.18081940
87Reduced antithrombin III activity (HP:0001976)2.17410704
88Sepsis (HP:0100806)2.17206875
89Increased serum ferritin (HP:0003281)2.16970138
90Gingival bleeding (HP:0000225)2.16431764
91Hepatic necrosis (HP:0002605)2.15914457
92Epistaxis (HP:0000421)2.13124590
93Hepatocellular necrosis (HP:0001404)2.12750467
94Joint swelling (HP:0001386)2.11499629
95Pallor (HP:0000980)2.09661443
96Recurrent pneumonia (HP:0006532)2.09131915
97Prolonged bleeding time (HP:0003010)2.08176313
98Colitis (HP:0002583)2.07373671
99Encephalitis (HP:0002383)2.07298878
100Bronchitis (HP:0012387)2.06949942
101Mitochondrial inheritance (HP:0001427)2.06808684
102Increased IgE level (HP:0003212)2.05349697
103Skin ulcer (HP:0200042)2.04638097
104Skin rash (HP:0000988)2.03851990
105Gangrene (HP:0100758)2.03625322
106Anorexia (HP:0002039)2.03492542
107Acute hepatic failure (HP:0006554)2.03320946
108Recurrent lower respiratory tract infections (HP:0002783)2.03083177
109Verrucae (HP:0200043)2.02241396
110Papilloma (HP:0012740)2.02241396
111Increased muscle lipid content (HP:0009058)2.01301669
112Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.00037457
113Osteomyelitis (HP:0002754)1.99674879
114B lymphocytopenia (HP:0010976)1.99394743
115Abnormality of B cell number (HP:0010975)1.99394743
116Keratoconjunctivitis (HP:0001096)1.98581994
117Neutropenia (HP:0001875)1.98093990
118Increased intramyocellular lipid droplets (HP:0012240)1.96465027
119Microcytic anemia (HP:0001935)1.95483090
120Nausea (HP:0002018)1.94355470
121Aplastic anemia (HP:0001915)1.93003879
122Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92414347

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.87891818
2TBK13.41810153
3TYK23.08709100
4BLK3.07202419
5IKBKE3.01794714
6MAP3K142.96169736
7NME22.93923097
8TXK2.72295060
9ERN12.69754822
10VRK22.61775473
11KIT2.59254026
12JAK32.42371459
13IRAK42.39443187
14ZAP702.27989664
15KDR2.20442523
16PIM22.15926366
17IRAK31.86843012
18IKBKB1.84516996
19EIF2AK11.80288631
20SYK1.77750009
21TEC1.77297505
22BTK1.69965448
23MST41.66132932
24FGFR41.65941412
25RIPK41.64198966
26JAK11.56413174
27MAP3K121.48360387
28GRK61.46177486
29BCKDK1.39109383
30STK161.32581585
31MAP3K131.31529057
32FLT31.30258627
33LCK1.17420035
34LYN1.16488666
35EIF2AK31.16439549
36CSF1R1.14219830
37RPS6KA41.09873476
38PRPF4B1.06620674
39CSK1.05720152
40GRK71.01085597
41MAP2K31.00894479
42TAOK21.00430073
43MAP3K110.99527618
44PBK0.99178577
45TGFBR10.98175653
46MYLK0.98086568
47NME10.97558576
48TAOK30.95897278
49NEK90.95752494
50ARAF0.95594813
51TESK20.94460027
52SMG10.91391648
53PIM10.90432387
54NLK0.88018148
55SCYL20.87593143
56ITK0.86425381
57LRRK20.86157570
58HCK0.85488107
59STK100.82275821
60CHUK0.80323010
61MST1R0.78377088
62FES0.77238725
63TGFBR20.74120766
64MATK0.73195263
65VRK10.73062625
66MARK30.71377359
67JAK20.69950483
68MAP2K60.69404108
69PIK3CG0.68496925
70ZAK0.67497574
71FGR0.67313118
72MAP3K10.67052768
73TAOK10.66387089
74CDK190.64575987
75BUB10.62384145
76NUAK10.61722278
77ABL20.61639230
78PKN20.60950333
79FGFR30.60057553
80TESK10.57776643
81MAP2K20.57663703
82ADRBK20.57212719
83ACVR1B0.57111095
84PRKCD0.54778284
85HIPK20.54705801
86EIF2AK20.53095562
87STK40.50227492
88PRKG20.50021351
89DAPK30.49562485
90TAF10.48665077
91PDK10.46698979
92DAPK10.44910102
93TLK10.44352776
94MAP3K100.43107690
95TIE10.42921886
96PRKCQ0.42368229
97CDK40.42268256
98MAPK110.42192217
99FYN0.41864662
100EPHB10.41803042
101MAPK120.40332504
102GRK50.39587404
103ILK0.38897552
104RPS6KB20.38511740
105RPS6KA60.38242197
106BMPR20.37342477
107TSSK60.36682775
108MAPKAPK30.36094637
109MAPK40.36041639
110RAF10.35560361
111MAP3K30.34393155
112MAP3K50.33996293
113MAP3K80.33462793
114TNK20.33018935
115EPHA30.33018825
116MAPKAPK20.32994789
117RPS6KA50.31900840
118SIK30.31370335
119IRAK10.30803089
120LIMK10.27882183
121RPS6KC10.27743516
122RPS6KL10.27743516
123ABL10.25717430
124PAK10.25605519
125PDPK10.24706948
126MAPK70.19816223
127MAPK30.19426157

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.23763960
2Primary immunodeficiency_Homo sapiens_hsa053403.14530505
3Ribosome_Homo sapiens_hsa030103.02105874
4Leishmaniasis_Homo sapiens_hsa051402.61049239
5* Proteasome_Homo sapiens_hsa030502.60104429
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.58978914
7Graft-versus-host disease_Homo sapiens_hsa053322.51330087
8Antigen processing and presentation_Homo sapiens_hsa046122.43062380
9Allograft rejection_Homo sapiens_hsa053302.39301188
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.28414446
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.22417711
12Measles_Homo sapiens_hsa051622.15584187
13Legionellosis_Homo sapiens_hsa051342.01159302
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96125089
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94066784
16DNA replication_Homo sapiens_hsa030301.93411211
17Staphylococcus aureus infection_Homo sapiens_hsa051501.83102583
18Pertussis_Homo sapiens_hsa051331.71587297
19Herpes simplex infection_Homo sapiens_hsa051681.69642672
20Influenza A_Homo sapiens_hsa051641.64974101
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.64100845
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.57347176
23Osteoclast differentiation_Homo sapiens_hsa043801.52323627
24Asthma_Homo sapiens_hsa053101.50782945
25Hematopoietic cell lineage_Homo sapiens_hsa046401.49785424
26Systemic lupus erythematosus_Homo sapiens_hsa053221.48919480
27Other glycan degradation_Homo sapiens_hsa005111.41429105
28Tuberculosis_Homo sapiens_hsa051521.29633469
29Malaria_Homo sapiens_hsa051441.29418691
30Oxidative phosphorylation_Homo sapiens_hsa001901.27436464
31Type I diabetes mellitus_Homo sapiens_hsa049401.26560532
32B cell receptor signaling pathway_Homo sapiens_hsa046621.22556401
33Pyrimidine metabolism_Homo sapiens_hsa002401.22530702
34Parkinsons disease_Homo sapiens_hsa050121.22472462
35Mismatch repair_Homo sapiens_hsa034301.22073867
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16253276
37Apoptosis_Homo sapiens_hsa042101.13354879
38African trypanosomiasis_Homo sapiens_hsa051431.12962885
39Base excision repair_Homo sapiens_hsa034101.12909219
40Toxoplasmosis_Homo sapiens_hsa051451.12749945
41Rheumatoid arthritis_Homo sapiens_hsa053231.11772079
42Folate biosynthesis_Homo sapiens_hsa007901.10276635
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10002980
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09692563
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.08560722
46Protein export_Homo sapiens_hsa030601.07690679
47Sulfur relay system_Homo sapiens_hsa041221.07434928
48TNF signaling pathway_Homo sapiens_hsa046681.06053137
49Autoimmune thyroid disease_Homo sapiens_hsa053201.04752376
50RNA polymerase_Homo sapiens_hsa030201.02059688
51Salmonella infection_Homo sapiens_hsa051321.01390691
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00097682
53Shigellosis_Homo sapiens_hsa051310.98772185
54Viral myocarditis_Homo sapiens_hsa054160.96154814
55Caffeine metabolism_Homo sapiens_hsa002320.94260545
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93588038
57Pentose phosphate pathway_Homo sapiens_hsa000300.91578571
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89911658
59T cell receptor signaling pathway_Homo sapiens_hsa046600.88201059
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84614574
61Hepatitis C_Homo sapiens_hsa051600.79306720
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77859094
63Epstein-Barr virus infection_Homo sapiens_hsa051690.76260077
64Homologous recombination_Homo sapiens_hsa034400.76186096
65Hepatitis B_Homo sapiens_hsa051610.75396552
66Lysosome_Homo sapiens_hsa041420.75366974
67Alzheimers disease_Homo sapiens_hsa050100.74237327
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68824940
69Chemokine signaling pathway_Homo sapiens_hsa040620.67252954
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66070709
71Nucleotide excision repair_Homo sapiens_hsa034200.65507180
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.62844591
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61713199
74Huntingtons disease_Homo sapiens_hsa050160.60304360
75One carbon pool by folate_Homo sapiens_hsa006700.58303245
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.57931593
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57307540
78Phagosome_Homo sapiens_hsa041450.56815995
79Galactose metabolism_Homo sapiens_hsa000520.55750551
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55457441
81Sulfur metabolism_Homo sapiens_hsa009200.53215888
82Fat digestion and absorption_Homo sapiens_hsa049750.52196398
83HTLV-I infection_Homo sapiens_hsa051660.51810986
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51418842
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.50763819
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47510082
87Arachidonic acid metabolism_Homo sapiens_hsa005900.46395711
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45295052
89Spliceosome_Homo sapiens_hsa030400.45091483
90Acute myeloid leukemia_Homo sapiens_hsa052210.43371790
91Platelet activation_Homo sapiens_hsa046110.41750585
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.40576564
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38011944
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37813540
95p53 signaling pathway_Homo sapiens_hsa041150.36554244
96Glutathione metabolism_Homo sapiens_hsa004800.36473411
97Peroxisome_Homo sapiens_hsa041460.35868840
98Renin-angiotensin system_Homo sapiens_hsa046140.34489685
99Purine metabolism_Homo sapiens_hsa002300.33874603
100Non-homologous end-joining_Homo sapiens_hsa034500.32717741
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31967460
102Viral carcinogenesis_Homo sapiens_hsa052030.31918233
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30537172
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30502501
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30410005
106Fructose and mannose metabolism_Homo sapiens_hsa000510.29725250
107Carbon metabolism_Homo sapiens_hsa012000.29265968
108Complement and coagulation cascades_Homo sapiens_hsa046100.29201346
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28396164
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26131616
111Histidine metabolism_Homo sapiens_hsa003400.26043627
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.25479215
113Collecting duct acid secretion_Homo sapiens_hsa049660.23597477
114Regulation of autophagy_Homo sapiens_hsa041400.19326944
115Endocytosis_Homo sapiens_hsa041440.19083846
116Fatty acid elongation_Homo sapiens_hsa000620.18303035
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.13301056
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.12251893
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.10296795
120Chemical carcinogenesis_Homo sapiens_hsa052040.09600502

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