PSMB11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1superoxide anion generation (GO:0042554)4.60391658
2dendritic cell chemotaxis (GO:0002407)3.53165211
3negative regulation of mast cell activation (GO:0033004)3.45524714
4polyketide metabolic process (GO:0030638)3.44125325
5doxorubicin metabolic process (GO:0044598)3.44125325
6daunorubicin metabolic process (GO:0044597)3.44125325
7energy homeostasis (GO:0097009)3.32978670
8regulation of activation of Janus kinase activity (GO:0010533)3.30125286
9detection of other organism (GO:0098543)3.15182033
10tRNA methylation (GO:0030488)3.13864946
11regulation of dendritic cell antigen processing and presentation (GO:0002604)3.10777714
12dendritic cell migration (GO:0036336)3.10707476
13centriole assembly (GO:0098534)3.08591904
14positive regulation of antigen processing and presentation (GO:0002579)3.07816379
15histamine secretion (GO:0001821)3.00633928
16interferon-gamma production (GO:0032609)2.99376178
17positive regulation of cellular amide metabolic process (GO:0034250)2.95715888
18regulation of antigen processing and presentation (GO:0002577)2.94631782
19positive regulation of interleukin-1 beta secretion (GO:0050718)2.93483510
20detection of bacterium (GO:0016045)2.93085651
21G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.84873592
22DNA integration (GO:0015074)2.82566526
23negative regulation of DNA-dependent DNA replication (GO:2000104)2.79216972
24regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.72027476
25mesenchymal cell differentiation involved in kidney development (GO:0072161)2.71608062
26mesenchymal cell differentiation involved in renal system development (GO:2001012)2.71608062
27positive regulation of interleukin-1 secretion (GO:0050716)2.66430837
28regulation of nuclear cell cycle DNA replication (GO:0033262)2.62818493
29replicative senescence (GO:0090399)2.61643330
30positive regulation of chemokine secretion (GO:0090197)2.60237958
31superoxide metabolic process (GO:0006801)2.59303083
32neutrophil activation involved in immune response (GO:0002283)2.58736509
33regulation of interleukin-1 beta secretion (GO:0050706)2.58011611
34G-protein coupled receptor internalization (GO:0002031)2.57118783
35response to peptidoglycan (GO:0032494)2.56173953
36cytochrome complex assembly (GO:0017004)2.55636994
37positive regulation of protein homodimerization activity (GO:0090073)2.53687799
38neutrophil activation (GO:0042119)2.53644883
39positive regulation of T cell migration (GO:2000406)2.53093410
40regulation of interleukin-8 secretion (GO:2000482)2.52947133
41dentate gyrus development (GO:0021542)2.50862131
42poly(A)+ mRNA export from nucleus (GO:0016973)2.50193260
43cell differentiation involved in metanephros development (GO:0072202)2.50141585
44myeloid dendritic cell activation (GO:0001773)2.49429972
45startle response (GO:0001964)2.48908092
46histamine transport (GO:0051608)2.48077408
47cellular response to gamma radiation (GO:0071480)2.48031902
48DNA synthesis involved in DNA repair (GO:0000731)2.47703134
49meiotic chromosome segregation (GO:0045132)2.45871376
50purinergic nucleotide receptor signaling pathway (GO:0035590)2.44695341
51lipoxygenase pathway (GO:0019372)2.42160571
52positive regulation of lymphocyte migration (GO:2000403)2.41534570
53positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.41282224
54monocyte chemotaxis (GO:0002548)2.40815219
55developmental pigmentation (GO:0048066)2.39431750
56negative regulation of viral genome replication (GO:0045071)2.38228575
57positive regulation of interleukin-10 production (GO:0032733)2.37938915
58positive regulation of uterine smooth muscle contraction (GO:0070474)2.37540322
59regulation of chemokine secretion (GO:0090196)2.37538542
60regulation of timing of cell differentiation (GO:0048505)2.35029085
61natural killer cell activation involved in immune response (GO:0002323)2.34955249
62regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.33447075
63negative regulation of keratinocyte proliferation (GO:0010839)2.32649173
64regulation of mast cell activation (GO:0033003)2.32597673
65extracellular negative regulation of signal transduction (GO:1900116)2.30714916
66extracellular regulation of signal transduction (GO:1900115)2.30714916
67DNA double-strand break processing (GO:0000729)2.29852347
68detection of molecule of bacterial origin (GO:0032490)2.29631020
69regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.29476572
70microtubule depolymerization (GO:0007019)2.29311242
71adenosine metabolic process (GO:0046085)2.27788566
72kinetochore assembly (GO:0051382)2.25932678
73female gonad development (GO:0008585)2.25513759
74regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.25459247
75regulation of mitotic spindle checkpoint (GO:1903504)2.25459247
76DNA ligation (GO:0006266)2.25244197
77granulocyte activation (GO:0036230)2.25147877
78modulation by virus of host process (GO:0019054)2.23082233
79detection of external biotic stimulus (GO:0098581)2.22183411
80regulation of cellular extravasation (GO:0002691)2.20830612
81centriole replication (GO:0007099)2.20098752
82positive regulation of interleukin-1 beta production (GO:0032731)2.19082451
83negative regulation of phagocytosis (GO:0050765)2.18953833
84protein K6-linked ubiquitination (GO:0085020)2.17702477
85germinal center formation (GO:0002467)2.17338182
86positive regulation of T cell chemotaxis (GO:0010820)2.17261002
87regulation of T cell chemotaxis (GO:0010819)2.17261002
88DNA strand renaturation (GO:0000733)2.17068175
89positive regulation of heat generation (GO:0031652)2.16318794
90DNA catabolic process, exonucleolytic (GO:0000738)2.15455504
91respiratory chain complex IV assembly (GO:0008535)2.15430332
92regulation of mast cell degranulation (GO:0043304)2.13243115
93regulation of interleukin-1 secretion (GO:0050704)2.11942375
94regulation of T cell migration (GO:2000404)2.09995883
95eosinophil chemotaxis (GO:0048245)2.09516475
96ceramide catabolic process (GO:0046514)2.09194098
97RNA-dependent DNA replication (GO:0006278)2.09054492
98DNA dealkylation (GO:0035510)2.08709051
99negative regulation of systemic arterial blood pressure (GO:0003085)2.07899444
100regulation of male gonad development (GO:2000018)2.07640010

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.52082528
2GBX2_23144817_ChIP-Seq_PC3_Human3.36988449
3PCGF2_27294783_Chip-Seq_ESCs_Mouse2.95499007
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.81585098
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.78638610
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72932196
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.72229600
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.42641179
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.40491505
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.40390125
11SUZ12_27294783_Chip-Seq_NPCs_Mouse2.40294022
12NFE2_27457419_Chip-Seq_LIVER_Mouse2.35412845
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.33328271
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.15787938
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.10323911
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08633254
17TP63_19390658_ChIP-ChIP_HaCaT_Human1.99551924
18BMI1_23680149_ChIP-Seq_NPCS_Mouse1.98288715
19STAT3_18555785_Chip-Seq_ESCs_Mouse1.97781575
20EZH2_27294783_Chip-Seq_NPCs_Mouse1.96685460
21EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.95572235
22E2F1_18555785_Chip-Seq_ESCs_Mouse1.92802521
23SUZ12_18555785_Chip-Seq_ESCs_Mouse1.91914578
24P53_22387025_ChIP-Seq_ESCs_Mouse1.90111827
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89461645
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88654956
27NMYC_18555785_Chip-Seq_ESCs_Mouse1.86134057
28TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.84458867
29EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.81790000
30NANOG_18555785_Chip-Seq_ESCs_Mouse1.81066304
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79839792
32P300_18555785_Chip-Seq_ESCs_Mouse1.74046148
33TAF15_26573619_Chip-Seq_HEK293_Human1.71700683
34P300_19829295_ChIP-Seq_ESCs_Human1.71267375
35RUNX1_27457419_Chip-Seq_LIVER_Mouse1.69461038
36ZFX_18555785_Chip-Seq_ESCs_Mouse1.68629304
37CMYC_18555785_Chip-Seq_ESCs_Mouse1.66653819
38EWS_26573619_Chip-Seq_HEK293_Human1.66614469
39SOX2_18555785_Chip-Seq_ESCs_Mouse1.65015757
40OCT4_18555785_Chip-Seq_ESCs_Mouse1.64786404
41E2F7_22180533_ChIP-Seq_HELA_Human1.64682492
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63301446
43PU1_27457419_Chip-Seq_LIVER_Mouse1.63060382
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57683970
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.57143300
46RNF2_27304074_Chip-Seq_NSC_Mouse1.56493051
47KLF4_18555785_Chip-Seq_ESCs_Mouse1.53375441
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52603691
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.49889548
50ESRRB_18555785_Chip-Seq_ESCs_Mouse1.49298263
51SMAD1_18555785_Chip-Seq_ESCs_Mouse1.47591039
52EZH2_22144423_ChIP-Seq_EOC_Human1.45888083
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45841031
54CTCF_18555785_Chip-Seq_ESCs_Mouse1.44675737
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44600329
56IGF1R_20145208_ChIP-Seq_DFB_Human1.44170797
57CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43941329
58FUS_26573619_Chip-Seq_HEK293_Human1.40381758
59VDR_22108803_ChIP-Seq_LS180_Human1.37416679
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36737499
61ER_23166858_ChIP-Seq_MCF-7_Human1.36367184
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36363486
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35925631
64CRX_20693478_ChIP-Seq_RETINA_Mouse1.32857152
65IRF1_19129219_ChIP-ChIP_H3396_Human1.32238157
66STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30012013
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29544982
68OCT4_21477851_ChIP-Seq_ESCs_Mouse1.29189126
69TAL1_26923725_Chip-Seq_HPCs_Mouse1.28124638
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26869515
71SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.23310725
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19038484
73SMAD4_21799915_ChIP-Seq_A2780_Human1.17653616
74EED_16625203_ChIP-ChIP_MESCs_Mouse1.17306865
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16849820
76TP53_18474530_ChIP-ChIP_U2OS_Human1.14171256
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10444403
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10444403
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.10057779
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07793355
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.05617313
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04594923
83LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04526195
84KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02128070
85CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01922729
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01137684
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.00389315
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99979558
89STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99695181
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99601161
91SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98884587
92SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98679720
93CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97067787
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96995773
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.96940234
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95522514
97SCL_19346495_ChIP-Seq_HPC-7_Human0.95228469
98CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92590373
99AR_25329375_ChIP-Seq_VCAP_Human0.91484965
100TCF4_23295773_ChIP-Seq_U87_Human0.91178651

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.91918511
2MP0001188_hyperpigmentation3.73460547
3MP0000566_synostosis3.34730616
4MP0001835_abnormal_antigen_presentation2.93661014
5MP0003136_yellow_coat_color2.85890552
6MP0005171_absent_coat_pigmentation2.59224043
7MP0002277_abnormal_respiratory_mucosa2.58606851
8MP0002148_abnormal_hypersensitivity_rea2.49610697
9MP0003941_abnormal_skin_development2.42142267
10MP0005671_abnormal_response_to2.21328699
11MP0002132_abnormal_respiratory_system2.19245679
12MP0000015_abnormal_ear_pigmentation2.13528930
13MP0009785_altered_susceptibility_to2.09554618
14MP0005646_abnormal_pituitary_gland2.09192053
15MP0004381_abnormal_hair_follicle2.04354480
16MP0003787_abnormal_imprinting2.02661731
17MP0008058_abnormal_DNA_repair2.01522825
18MP0005174_abnormal_tail_pigmentation1.94235587
19MP0001986_abnormal_taste_sensitivity1.86801896
20MP0002102_abnormal_ear_morphology1.81623795
21MP0005645_abnormal_hypothalamus_physiol1.80850194
22MP0004782_abnormal_surfactant_physiolog1.78174816
23MP0005409_darkened_coat_color1.77796366
24MP0008057_abnormal_DNA_replication1.76348548
25MP0003724_increased_susceptibility_to1.75134955
26MP0009697_abnormal_copulation1.73250844
27MP0002396_abnormal_hematopoietic_system1.67673912
28MP0005387_immune_system_phenotype1.66597781
29MP0001790_abnormal_immune_system1.66597781
30MP0002419_abnormal_innate_immunity1.65481616
31MP0001984_abnormal_olfaction1.62222397
32MP0005075_abnormal_melanosome_morpholog1.57978024
33MP0003763_abnormal_thymus_physiology1.52245939
34MP0005000_abnormal_immune_tolerance1.49443523
35MP0002095_abnormal_skin_pigmentation1.47608523
36MP0000372_irregular_coat_pigmentation1.45691372
37MP0002638_abnormal_pupillary_reflex1.41975758
38MP0002452_abnormal_antigen_presenting1.41634906
39MP0005025_abnormal_response_to1.40795228
40MP0008007_abnormal_cellular_replicative1.40530718
41MP0002163_abnormal_gland_morphology1.40301928
42MP0002938_white_spotting1.35866427
43MP0010386_abnormal_urinary_bladder1.35670385
44MP0009764_decreased_sensitivity_to1.33013852
45MP0002876_abnormal_thyroid_physiology1.31990986
46MP0002723_abnormal_immune_serum1.27623450
47MP0001819_abnormal_immune_cell1.27347653
48MP0001800_abnormal_humoral_immune1.27199868
49MP0002420_abnormal_adaptive_immunity1.26695166
50MP0008004_abnormal_stomach_pH1.22313507
51MP0010094_abnormal_chromosome_stability1.21698472
52MP0008789_abnormal_olfactory_epithelium1.19463225
53MP0005379_endocrine/exocrine_gland_phen1.17684939
54MP0000681_abnormal_thyroid_gland1.12622443
55MP0003436_decreased_susceptibility_to1.11161754
56MP0008995_early_reproductive_senescence1.08810727
57MP0000516_abnormal_urinary_system1.08429484
58MP0005367_renal/urinary_system_phenotyp1.08429484
59MP0003786_premature_aging1.08141409
60MP0000026_abnormal_inner_ear1.07922916
61MP0002405_respiratory_system_inflammati1.06978329
62MP0001853_heart_inflammation1.01742401
63MP0001346_abnormal_lacrimal_gland0.96964417
64MP0008877_abnormal_DNA_methylation0.95629498
65MP0001119_abnormal_female_reproductive0.94991102
66MP0008260_abnormal_autophagy0.92237270
67MP0002735_abnormal_chemical_nociception0.90395424
68MP0000490_abnormal_crypts_of0.89494850
69MP0010155_abnormal_intestine_physiology0.88418007
70MP0000613_abnormal_salivary_gland0.87141797
71MP0001186_pigmentation_phenotype0.86354073
72MP0001919_abnormal_reproductive_system0.86258629
73MP0000685_abnormal_immune_system0.86164685
74MP0005389_reproductive_system_phenotype0.85968235
75MP0000049_abnormal_middle_ear0.85750239
76MP0004147_increased_porphyrin_level0.85305373
77MP0005310_abnormal_salivary_gland0.84378883
78MP0002160_abnormal_reproductive_system0.82850302
79MP0002006_tumorigenesis0.82104589
80MP0005394_taste/olfaction_phenotype0.81965785
81MP0005499_abnormal_olfactory_system0.81965785
82* MP0000716_abnormal_immune_system0.81960141
83MP0002398_abnormal_bone_marrow0.79652086
84MP0002009_preneoplasia0.79454945
85MP0001963_abnormal_hearing_physiology0.75919052
86MP0001873_stomach_inflammation0.73205800
87MP0003111_abnormal_nucleus_morphology0.73015430
88MP0002138_abnormal_hepatobiliary_system0.72210374
89MP0003828_pulmonary_edema0.71994128
90MP0002177_abnormal_outer_ear0.71930052
91MP0002998_abnormal_bone_remodeling0.70655925
92MP0000678_abnormal_parathyroid_gland0.69521838
93MP0003943_abnormal_hepatobiliary_system0.69244301
94MP0005084_abnormal_gallbladder_morpholo0.67725258
95MP0006082_CNS_inflammation0.66737349
96MP0002075_abnormal_coat/hair_pigmentati0.65675239
97MP0009333_abnormal_splenocyte_physiolog0.64160810
98MP0002933_joint_inflammation0.64103612
99MP0001502_abnormal_circadian_rhythm0.64102434
100MP0002736_abnormal_nociception_after0.63074863

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.42822744
2Chromsome breakage (HP:0040012)5.04400829
3Duplicated collecting system (HP:0000081)3.59607486
4Abnormality of the renal collecting system (HP:0004742)3.56622849
5Optic neuritis (HP:0100653)3.54864114
6Retrobulbar optic neuritis (HP:0100654)3.54864114
7Prostate neoplasm (HP:0100787)3.16447884
8Recurrent abscess formation (HP:0002722)2.92845298
9Orchitis (HP:0100796)2.82593876
10Abnormality of the preputium (HP:0100587)2.81867060
11White forelock (HP:0002211)2.79806049
12Clubbing of toes (HP:0100760)2.74954840
13Ectopic kidney (HP:0000086)2.74424139
14Abnormality of DNA repair (HP:0003254)2.70647640
15Stomach cancer (HP:0012126)2.65073957
16True hermaphroditism (HP:0010459)2.64503063
17Abnormality of incisor morphology (HP:0011063)2.63499838
18Aplasia/Hypoplasia of the uvula (HP:0010293)2.62890560
19Patchy hypopigmentation of hair (HP:0011365)2.61189619
20Febrile seizures (HP:0002373)2.58237516
21Septo-optic dysplasia (HP:0100842)2.57454695
22Abnormal hair whorl (HP:0010721)2.57045086
23Myositis (HP:0100614)2.54781870
24Alveolar cell carcinoma (HP:0006519)2.46040538
25Meckel diverticulum (HP:0002245)2.44483203
26Type I transferrin isoform profile (HP:0003642)2.41251535
27Eczematoid dermatitis (HP:0000976)2.40059872
28Congenital sensorineural hearing impairment (HP:0008527)2.37758304
29Recurrent pneumonia (HP:0006532)2.36149037
30Abnormality of chromosome stability (HP:0003220)2.30336412
31Abnormality of the ileum (HP:0001549)2.28741815
32Aplasia/Hypoplasia of the fovea (HP:0008060)2.27793703
33Hypoplasia of the fovea (HP:0007750)2.27793703
34Abnormal respiratory epithelium morphology (HP:0012253)2.25537780
35Abnormal respiratory motile cilium morphology (HP:0005938)2.25537780
36Obstructive lung disease (HP:0006536)2.21470210
37Chronic obstructive pulmonary disease (HP:0006510)2.21470210
38Recurrent bacterial skin infections (HP:0005406)2.19203282
39Abnormal ciliary motility (HP:0012262)2.18839512
40Renal cortical cysts (HP:0000803)2.18577046
41Abnormality of the prostate (HP:0008775)2.13442068
42Keratoconjunctivitis sicca (HP:0001097)2.12652250
43Pancreatic fibrosis (HP:0100732)2.11599766
44Conical tooth (HP:0000698)2.10226206
45Aplasia cutis congenita (HP:0001057)2.09526769
46Mediastinal lymphadenopathy (HP:0100721)2.07849268
47Recurrent cutaneous fungal infections (HP:0011370)2.05974946
48Chronic mucocutaneous candidiasis (HP:0002728)2.05974946
49Keratoconjunctivitis (HP:0001096)2.05248819
50Optic nerve hypoplasia (HP:0000609)2.02430374
51Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.02279072
52Absent/shortened dynein arms (HP:0200106)1.99387075
53Dynein arm defect of respiratory motile cilia (HP:0012255)1.99387075
54Duplication of thumb phalanx (HP:0009942)1.99089632
55Neoplasm of the tracheobronchial system (HP:0100552)1.98849308
56Hypothermia (HP:0002045)1.97979655
57Medial flaring of the eyebrow (HP:0010747)1.95448016
58Type 2 muscle fiber atrophy (HP:0003554)1.95246706
59Hypergonadotropic hypogonadism (HP:0000815)1.92874566
60Abnormality of the nasal septum (HP:0000419)1.91416625
61Reduced antithrombin III activity (HP:0001976)1.90057470
62Fair hair (HP:0002286)1.89783515
63Increased IgM level (HP:0003496)1.88047434
64Pancreatic cysts (HP:0001737)1.87045615
65Nephronophthisis (HP:0000090)1.85671267
66Submucous cleft hard palate (HP:0000176)1.84963177
67Bone marrow hypocellularity (HP:0005528)1.83404142
68Meningitis (HP:0001287)1.82773456
69Lip pit (HP:0100267)1.82699008
70Glomerulopathy (HP:0100820)1.79597201
71Protruding tongue (HP:0010808)1.79056384
72Recurrent lower respiratory tract infections (HP:0002783)1.78916647
73Nasolacrimal duct obstruction (HP:0000579)1.78583403
74Encephalitis (HP:0002383)1.77572606
75Abnormality of the fovea (HP:0000493)1.77348629
76Abnormality of the renal medulla (HP:0100957)1.76841424
77Xerostomia (HP:0000217)1.75982026
78Nephrogenic diabetes insipidus (HP:0009806)1.75504470
79Abnormality of the incisor (HP:0000676)1.75289214
80Abnormal respiratory motile cilium physiology (HP:0012261)1.75247348
81Chronic hepatic failure (HP:0100626)1.74832524
82Upper limb muscle weakness (HP:0003484)1.73965048
83Small intestinal stenosis (HP:0012848)1.73238589
84Duodenal stenosis (HP:0100867)1.73238589
85Abnormal delayed hypersensitivity skin test (HP:0002963)1.72339878
86Preaxial hand polydactyly (HP:0001177)1.72211290
87Postaxial foot polydactyly (HP:0001830)1.71815284
88Decreased central vision (HP:0007663)1.71667860
89Pulmonary infiltrates (HP:0002113)1.71109121
90Generalized hypopigmentation of hair (HP:0011358)1.70883751
91Tubulointerstitial nephritis (HP:0001970)1.70593709
92Male pseudohermaphroditism (HP:0000037)1.70158187
93Median cleft lip (HP:0000161)1.70095155
94Keratitis (HP:0000491)1.69898453
95Recurrent fungal infections (HP:0002841)1.67487231
96Prolonged neonatal jaundice (HP:0006579)1.67267062
97Osteomalacia (HP:0002749)1.65612999
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.64933278
99Elevated erythrocyte sedimentation rate (HP:0003565)1.64464692
100Congenital primary aphakia (HP:0007707)1.63916982

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.49682806
2ZAK3.24052872
3TXK2.89197683
4IRAK32.86849436
5SIK32.74865713
6CASK2.69214937
7IRAK42.57316597
8MKNK22.35906064
9BMPR22.23499030
10STK162.06092733
11PRPF4B2.04567240
12TNIK1.99496012
13EIF2AK21.96355909
14YES11.92398390
15INSRR1.89428933
16MKNK11.81002928
17BMPR1B1.71299307
18NUAK11.70500721
19ERBB31.64534701
20ADRBK21.62559472
21TEC1.59113047
22BRD41.50944740
23NEK61.48518395
24PLK41.43502894
25SRPK11.41907198
26GRK11.40273030
27TIE11.36656001
28MAP2K71.35421508
29IKBKB1.32422035
30GRK71.31171664
31VRK11.28624314
32IKBKE1.28451301
33PIM21.24446535
34STK38L1.23301005
35AKT31.21812074
36PBK1.19274108
37NLK1.18298111
38BLK1.16301598
39CDK31.15123889
40SGK21.05827902
41TRPM71.05045872
42MAPK131.04647655
43JAK31.01676220
44PINK11.00996353
45CDK80.98827421
46CLK10.97639707
47MST40.92286190
48CHUK0.91180194
49IRAK10.89525124
50TAOK20.84901825
51BTK0.84416233
52STK240.80410703
53BCR0.80098682
54MAPK150.80034095
55FRK0.77046358
56NEK90.76700494
57MUSK0.73778444
58TNK20.73715909
59ATR0.73635510
60MAP3K120.70674700
61KIT0.67767119
62LYN0.64282302
63PLK20.61594649
64PRKCE0.59592899
65TAOK30.59057888
66MAPK70.58970146
67PLK30.58244737
68MAP3K130.57579062
69IRAK20.56934308
70EPHA30.56696360
71PIM10.55934849
72BRAF0.54663382
73EPHB20.51387648
74RIPK40.48691653
75SIK20.45944083
76TBK10.44959849
77ACVR1B0.43714917
78SGK2230.43256123
79SGK4940.43256123
80SYK0.42425675
81PKN10.41314189
82TSSK60.40795679
83CCNB10.40192780
84PIK3CG0.38867825
85PIK3CA0.37506923
86PASK0.36840173
87PRKCD0.36689906
88RPS6KA50.36686722
89DYRK20.36409507
90TYK20.35795119
91LCK0.35377405
92SGK30.34721046
93RPS6KA60.34258504
94MARK30.32972555
95ATM0.32734599
96CDK70.32053536
97EIF2AK10.31006763
98PLK10.30079747
99CDK90.29672288
100TTK0.29419033

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.95734541
2Fanconi anemia pathway_Homo sapiens_hsa034602.78322646
3Graft-versus-host disease_Homo sapiens_hsa053322.60232630
4Allograft rejection_Homo sapiens_hsa053302.46926620
5Homologous recombination_Homo sapiens_hsa034402.40055119
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.25428597
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.23679748
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.18285041
9Autoimmune thyroid disease_Homo sapiens_hsa053201.97865515
10Non-homologous end-joining_Homo sapiens_hsa034501.77239829
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.71325132
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68446285
13Rheumatoid arthritis_Homo sapiens_hsa053231.65290617
14Base excision repair_Homo sapiens_hsa034101.60436665
15Measles_Homo sapiens_hsa051621.59201182
16Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.58898161
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58017472
18RNA polymerase_Homo sapiens_hsa030201.57219612
19DNA replication_Homo sapiens_hsa030301.55831650
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52365507
21Type I diabetes mellitus_Homo sapiens_hsa049401.52332777
22Hematopoietic cell lineage_Homo sapiens_hsa046401.50765079
23Mismatch repair_Homo sapiens_hsa034301.49551355
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47855239
25Leishmaniasis_Homo sapiens_hsa051401.47401982
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.46297489
27Primary immunodeficiency_Homo sapiens_hsa053401.46153067
28Basal transcription factors_Homo sapiens_hsa030221.42619312
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41513599
30Asthma_Homo sapiens_hsa053101.36946758
31Herpes simplex infection_Homo sapiens_hsa051681.36160817
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35350654
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31826903
34Arachidonic acid metabolism_Homo sapiens_hsa005901.30578609
35Influenza A_Homo sapiens_hsa051641.25633464
36Nucleotide excision repair_Homo sapiens_hsa034201.23417894
37Sphingolipid metabolism_Homo sapiens_hsa006001.13055376
38Legionellosis_Homo sapiens_hsa051341.11239470
39TNF signaling pathway_Homo sapiens_hsa046681.09496857
40Malaria_Homo sapiens_hsa051441.07678283
41Phototransduction_Homo sapiens_hsa047441.07629307
42Pyrimidine metabolism_Homo sapiens_hsa002401.05600145
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02467298
44Pertussis_Homo sapiens_hsa051331.02342506
45RNA degradation_Homo sapiens_hsa030181.01493248
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.98806724
47Nicotine addiction_Homo sapiens_hsa050330.96412849
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91478137
49Purine metabolism_Homo sapiens_hsa002300.91366732
50Other glycan degradation_Homo sapiens_hsa005110.90903253
51African trypanosomiasis_Homo sapiens_hsa051430.87062764
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86658968
53Taste transduction_Homo sapiens_hsa047420.86371250
54Osteoclast differentiation_Homo sapiens_hsa043800.85745419
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84261324
56Protein export_Homo sapiens_hsa030600.83454306
57One carbon pool by folate_Homo sapiens_hsa006700.79111305
58Olfactory transduction_Homo sapiens_hsa047400.76455926
59Tuberculosis_Homo sapiens_hsa051520.74727942
60p53 signaling pathway_Homo sapiens_hsa041150.70810044
61Apoptosis_Homo sapiens_hsa042100.70772554
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69948402
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69210994
64Chemokine signaling pathway_Homo sapiens_hsa040620.68237703
65Vitamin digestion and absorption_Homo sapiens_hsa049770.67882002
66Hepatitis B_Homo sapiens_hsa051610.62968057
67Phagosome_Homo sapiens_hsa041450.62387224
68Serotonergic synapse_Homo sapiens_hsa047260.58585967
69Morphine addiction_Homo sapiens_hsa050320.57938725
70Salmonella infection_Homo sapiens_hsa051320.56731153
71Epstein-Barr virus infection_Homo sapiens_hsa051690.55795807
72Regulation of autophagy_Homo sapiens_hsa041400.54269644
73Hepatitis C_Homo sapiens_hsa051600.53871603
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53605320
75Spliceosome_Homo sapiens_hsa030400.53035305
76Toxoplasmosis_Homo sapiens_hsa051450.51463045
77Cell cycle_Homo sapiens_hsa041100.49796118
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48891100
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.48481681
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.46513832
81Melanoma_Homo sapiens_hsa052180.44491790
82Ether lipid metabolism_Homo sapiens_hsa005650.44309979
83T cell receptor signaling pathway_Homo sapiens_hsa046600.43734253
84Staphylococcus aureus infection_Homo sapiens_hsa051500.43668613
85HTLV-I infection_Homo sapiens_hsa051660.42605566
86Ovarian steroidogenesis_Homo sapiens_hsa049130.42259895
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40159326
88Antigen processing and presentation_Homo sapiens_hsa046120.38898125
89Basal cell carcinoma_Homo sapiens_hsa052170.38026675
90Retinol metabolism_Homo sapiens_hsa008300.36803974
91Collecting duct acid secretion_Homo sapiens_hsa049660.36405466
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36082630
93B cell receptor signaling pathway_Homo sapiens_hsa046620.36036487
94Notch signaling pathway_Homo sapiens_hsa043300.32565482
95Shigellosis_Homo sapiens_hsa051310.29719349
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29356572
97Calcium signaling pathway_Homo sapiens_hsa040200.29270391
98Linoleic acid metabolism_Homo sapiens_hsa005910.27100754
99* Proteasome_Homo sapiens_hsa030500.25791653
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24492038

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