ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.78242311
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.25569720
3	ATP synthesis coupled proton transport (GO:0015986)	6.25569720
4	ribosomal small subunit biogenesis (GO:0042274)	5.99582636
5	proteasome assembly (GO:0043248)	5.64868101
6	viral transcription (GO:0019083)	5.56866786
7	ribosomal small subunit assembly (GO:0000028)	5.54791028
8	translational termination (GO:0006415)	5.42364797
9	maturation of SSU-rRNA (GO:0030490)	5.11837253
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.90349343
11	cotranslational protein targeting to membrane (GO:0006613)	4.89276420
12	protein targeting to ER (GO:0045047)	4.83555002
13	* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	4.79672983
14	translational elongation (GO:0006414)	4.75725382
15	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.72108874
16	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.67937735
17	ribosomal large subunit biogenesis (GO:0042273)	4.62748606
18	protein localization to endoplasmic reticulum (GO:0070972)	4.62150200
19	DNA deamination (GO:0045006)	4.59447297
20	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.58768398
21	respiratory electron transport chain (GO:0022904)	4.48745882
22	translational initiation (GO:0006413)	4.45700580
23	* regulation of cellular amino acid metabolic process (GO:0006521)	4.44225446
24	* negative regulation of ubiquitin-protein transferase activity (GO:0051444)	4.43323220
25	* negative regulation of ligase activity (GO:0051352)	4.43323220
26	termination of RNA polymerase III transcription (GO:0006386)	4.43166367
27	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.43166367
28	* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	4.42080361
29	protein neddylation (GO:0045116)	4.40065693
30	electron transport chain (GO:0022900)	4.39590315
31	cellular protein complex disassembly (GO:0043624)	4.38565973
32	viral life cycle (GO:0019058)	4.36626210
33	* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	4.33728313
34	* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	4.31292765
35	translation (GO:0006412)	4.30434686
36	chaperone-mediated protein transport (GO:0072321)	4.30093182
37	* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	4.25277473
38	* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	4.25277473
39	* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	4.24663913
40	cullin deneddylation (GO:0010388)	4.24033489
41	* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	4.22353471
42	* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	4.22353471
43	* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	4.22353471
44	formation of translation preinitiation complex (GO:0001731)	4.15973932
45	* signal transduction involved in DNA damage checkpoint (GO:0072422)	4.15722357
46	* signal transduction involved in DNA integrity checkpoint (GO:0072401)	4.15722357
47	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.15188681
48	establishment of integrated proviral latency (GO:0075713)	4.12964073
49	* signal transduction involved in cell cycle checkpoint (GO:0072395)	4.10718864
50	ribonucleoprotein complex biogenesis (GO:0022613)	4.10156418
51	* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	4.07747367
52	protein deneddylation (GO:0000338)	4.01714687
53	7-methylguanosine mRNA capping (GO:0006370)	3.92269931
54	RNA capping (GO:0036260)	3.86569388
55	7-methylguanosine RNA capping (GO:0009452)	3.86569388
56	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.82116072
57	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.82116072
58	NADH dehydrogenase complex assembly (GO:0010257)	3.82116072
59	* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.78889107
60	* positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.76837821
61	rRNA modification (GO:0000154)	3.76750128
62	cellular component biogenesis (GO:0044085)	3.75937303
63	protein complex disassembly (GO:0043241)	3.72449561
64	establishment of protein localization to mitochondrion (GO:0072655)	3.71859062
65	rRNA processing (GO:0006364)	3.71288013
66	* negative regulation of protein ubiquitination (GO:0031397)	3.69218127
67	GTP biosynthetic process (GO:0006183)	3.67536404
68	oxidative phosphorylation (GO:0006119)	3.65882056
69	spliceosomal snRNP assembly (GO:0000387)	3.65563223
70	protein targeting to mitochondrion (GO:0006626)	3.65210363
71	protein complex biogenesis (GO:0070271)	3.65055853
72	respiratory chain complex IV assembly (GO:0008535)	3.65051073
73	* positive regulation of ligase activity (GO:0051351)	3.63345351
74	regulation of mitochondrial translation (GO:0070129)	3.57111053
75	establishment of viral latency (GO:0019043)	3.56751318
76	macromolecular complex disassembly (GO:0032984)	3.56595484
77	rRNA metabolic process (GO:0016072)	3.55821542
78	DNA strand elongation involved in DNA replication (GO:0006271)	3.52973815
79	cytochrome complex assembly (GO:0017004)	3.51841161
80	* negative regulation of protein modification by small protein conjugation or removal (GO:1903321)	3.50780421
81	telomere maintenance via semi-conservative replication (GO:0032201)	3.47166614
82	* antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	3.45961987
83	pseudouridine synthesis (GO:0001522)	3.45034242
84	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.43863084
85	UTP biosynthetic process (GO:0006228)	3.43257418
86	mitochondrial respiratory chain complex assembly (GO:0033108)	3.42893039
87	ribosome assembly (GO:0042255)	3.41455082
88	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.41051299
89	* signal transduction in response to DNA damage (GO:0042770)	3.38506725
90	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.37616167
91	transcription-coupled nucleotide-excision repair (GO:0006283)	3.36700768
92	* regulation of ubiquitin-protein transferase activity (GO:0051438)	3.36433595
93	protein localization to mitochondrion (GO:0070585)	3.36217652
94	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.35465482
95	nucleobase biosynthetic process (GO:0046112)	3.35155125
96	* DNA damage response, signal transduction by p53 class mediator (GO:0030330)	3.34317059
97	* positive regulation of cell cycle arrest (GO:0071158)	3.34302515
98	spliceosomal complex assembly (GO:0000245)	3.33942337
99	DNA strand elongation (GO:0022616)	3.33800042
100	* regulation of cellular amine metabolic process (GO:0033238)	3.32760408
101	guanosine-containing compound biosynthetic process (GO:1901070)	3.29549622
102	* regulation of cell cycle arrest (GO:0071156)	3.29364253
103	* regulation of ligase activity (GO:0051340)	3.26921132
104	protein maturation by protein folding (GO:0022417)	3.22897538
105	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.21969365
106	DNA replication initiation (GO:0006270)	3.21689766
107	transcription from RNA polymerase I promoter (GO:0006360)	3.21323271
108	ribosome biogenesis (GO:0042254)	3.20712905
109	* G1/S transition of mitotic cell cycle (GO:0000082)	3.20285819
110	* cell cycle G1/S phase transition (GO:0044843)	3.20285819
111	* negative regulation of cell cycle G1/S phase transition (GO:1902807)	3.20250234
112	* negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)	3.20250234
113	purine nucleobase biosynthetic process (GO:0009113)	3.20075053
114	DNA catabolic process, exonucleolytic (GO:0000738)	3.04230116
115	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.04120663
116	nucleobase-containing small molecule interconversion (GO:0015949)	3.01614757
117	inner mitochondrial membrane organization (GO:0007007)	2.97087550
118	* positive regulation of protein ubiquitination (GO:0031398)	2.95451266
119	nucleoside salvage (GO:0043174)	2.91190657
120	maturation of 5.8S rRNA (GO:0000460)	2.90788073
121	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.85744924
122	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.85744924
123	telomere maintenance via recombination (GO:0000722)	2.82038119
124	rRNA methylation (GO:0031167)	2.80651089
125	GDP-mannose metabolic process (GO:0019673)	2.78369444
126	mitochondrial transport (GO:0006839)	2.78084758
127	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.77597743
128	pteridine-containing compound biosynthetic process (GO:0042559)	2.73564684
129	* positive regulation of protein modification by small protein conjugation or removal (GO:1903322)	2.73379419
130	DNA replication checkpoint (GO:0000076)	2.73002022
131	* regulation of G1/S transition of mitotic cell cycle (GO:2000045)	2.71560282
132	DNA double-strand break processing (GO:0000729)	2.68442509

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.71319078
2	E2F7_22180533_ChIP-Seq_HELA_Human	4.47198009
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.38806596
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.30684403
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.26640545
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.17602445
7	* JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.98533188
8	* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.92204040
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.77382844
10	* ETS1_20019798_ChIP-Seq_JURKAT_Human	3.72443565
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.55444110
12	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.32610186
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.31297348
14	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	3.20159265
15	* CHD1_19587682_ChIP-ChIP_MESCs_Mouse	3.15577509
16	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.06426319
17	MYC_19079543_ChIP-ChIP_MESCs_Mouse	3.05045747
18	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.90512299
19	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.89765492
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.63053290
21	XRN2_22483619_ChIP-Seq_HELA_Human	2.54131264
22	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.53396217
23	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.51827070
24	DCP1A_22483619_ChIP-Seq_HELA_Human	2.42247182
25	* E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.40574542
26	* THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.34977214
27	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.27658085
28	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.24937826
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.24582742
30	* NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.24055505
31	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.16220223
32	FOXP3_21729870_ChIP-Seq_TREG_Human	2.13263256
33	TTF2_22483619_ChIP-Seq_HELA_Human	2.06115879
34	* ELK1_19687146_ChIP-ChIP_HELA_Human	2.02178731
35	GABP_19822575_ChIP-Seq_HepG2_Human	2.00289294
36	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.96909504
37	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.86712743
38	* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.78815978
39	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.75473084
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.64899613
41	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.59949636
42	* ELK1_22589737_ChIP-Seq_MCF10A_Human	1.56301981
43	* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.54218480
44	* HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.53204593
45	* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.51479900
46	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.50066244
47	* MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.49004333
48	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.45904193
49	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.45755599
50	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.45609711
51	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.45431211
52	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.36711517
53	* FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.34748436
54	* TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.33399190
55	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.30551819
56	* ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.25696553
57	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.24650598
58	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.24241149
59	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.22623135
60	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.21674910
61	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.20708904
62	AR_21909140_ChIP-Seq_LNCAP_Human	1.19873447
63	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.19713234
64	* MYC_18940864_ChIP-ChIP_HL60_Human	1.18093693
65	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.17704524
66	* CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.17364586
67	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.16001312
68	* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.14252242
69	KDM5A_27292631_Chip-Seq_BREAST_Human	1.14113904
70	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.11165878
71	IRF1_19129219_ChIP-ChIP_H3396_Human	1.10145431
72	CIITA_25753668_ChIP-Seq_RAJI_Human	1.08662282
73	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.06860718
74	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.01504294
75	* OCT4_18692474_ChIP-Seq_MEFs_Mouse	1.00466446
76	* SOX17_20123909_ChIP-Seq_XEN_Mouse	0.98966069
77	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.98116470
78	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.97279369
79	ELF5_23300383_ChIP-Seq_T47D_Human	0.95405977
80	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.95266134
81	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.93624259
82	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.92356408
83	* SPI1_23547873_ChIP-Seq_NB4_Human	0.91856860
84	* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.91573861
85	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.90906271
86	* SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.89236284
87	* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.89002861
88	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.88735358
89	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.88588501
90	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.88436543
91	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.86487269
92	* NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.86034450
93	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.85942186
94	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.85309356
95	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.85289058
96	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.83763985
97	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.83747954
98	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.82822657
99	* HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.82207816
100	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.81843027
101	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.81795450
102	* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.81223924
103	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.80512284
104	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.79936932
105	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.79737943
106	TFEB_21752829_ChIP-Seq_HELA_Human	0.78752087
107	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.78202350
108	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.78166358
109	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.78028319
110	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.76824144
111	* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.75501043
112	NANOG_18692474_ChIP-Seq_MEFs_Mouse	0.75229451
113	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.75173159
114	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.73604020
115	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.73604020
116	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.71191639
117	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.70513957
118	ZNF263_19887448_ChIP-Seq_K562_Human	0.69701050

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	5.06487653
2	MP0004957_abnormal_blastocyst_morpholog	4.54377602
3	MP0009379_abnormal_foot_pigmentation	4.04731576
4	MP0003806_abnormal_nucleotide_metabolis	3.96086764
5	MP0010094_abnormal_chromosome_stability	3.28782806
6	MP0003077_abnormal_cell_cycle	3.21668534
7	MP0008932_abnormal_embryonic_tissue	3.15327345
8	MP0008057_abnormal_DNA_replication	3.12536271
9	MP0003111_abnormal_nucleus_morphology	3.07403071
10	MP0001529_abnormal_vocalization	3.02438278
11	MP0003718_maternal_effect	2.88483479
12	MP0008058_abnormal_DNA_repair	2.80189979
13	MP0003186_abnormal_redox_activity	2.67856487
14	MP0009697_abnormal_copulation	2.55094752
15	MP0003786_premature_aging	2.52875206
16	MP0001905_abnormal_dopamine_level	2.44011006
17	MP0006035_abnormal_mitochondrial_morpho	2.28980203
18	MP0006036_abnormal_mitochondrial_physio	2.28476095
19	MP0003136_yellow_coat_color	2.18517522
20	MP0008007_abnormal_cellular_replicative	2.06452245
21	MP0008875_abnormal_xenobiotic_pharmacok	2.02697539
22	MP0003315_abnormal_perineum_morphology	1.94214997
23	MP0005671_abnormal_response_to	1.69423772
24	MP0000372_irregular_coat_pigmentation	1.62152039
25	MP0001730_embryonic_growth_arrest	1.60508546
26	MP0009333_abnormal_splenocyte_physiolog	1.58637501
27	MP0003123_paternal_imprinting	1.58548978
28	MP0005408_hypopigmentation	1.57474235
29	MP0002132_abnormal_respiratory_system	1.56652790
30	MP0005075_abnormal_melanosome_morpholog	1.53608449
31	MP0001727_abnormal_embryo_implantation	1.50737063
32	MP0001835_abnormal_antigen_presentation	1.49693782
33	MP0008995_early_reproductive_senescence	1.49279538
34	MP0003191_abnormal_cellular_cholesterol	1.41839592
35	MP0004133_heterotaxia	1.41756400
36	MP0006292_abnormal_olfactory_placode	1.39674760
37	MP0003195_calcinosis	1.37316451
38	MP0000350_abnormal_cell_proliferation	1.35854003
39	MP0003011_delayed_dark_adaptation	1.32836409
40	MP0005084_abnormal_gallbladder_morpholo	1.32148907
41	MP0000358_abnormal_cell_content/	1.30504452
42	MP0004381_abnormal_hair_follicle	1.29576265
43	MP0006276_abnormal_autonomic_nervous	1.24728387
44	MP0005645_abnormal_hypothalamus_physiol	1.20924044
45	MP0002751_abnormal_autonomic_nervous	1.19990273
46	MP0002938_white_spotting	1.19917407
47	MP0004142_abnormal_muscle_tone	1.19225146
48	MP0002163_abnormal_gland_morphology	1.16029789
49	MP0002837_dystrophic_cardiac_calcinosis	1.15885730
50	MP0005266_abnormal_metabolism	1.14338476
51	MP0001542_abnormal_bone_strength	1.12300382
52	MP0005332_abnormal_amino_acid	1.11169387
53	MP0000313_abnormal_cell_death	1.08608301
54	MP0001881_abnormal_mammary_gland	1.08522235
55	MP0008789_abnormal_olfactory_epithelium	1.05644374
56	MP0005379_endocrine/exocrine_gland_phen	1.04622024
57	MP0001764_abnormal_homeostasis	1.03573242
58	MP0002160_abnormal_reproductive_system	1.03236019
59	MP0002166_altered_tumor_susceptibility	1.00989457
60	MP0000490_abnormal_crypts_of	1.00958950
61	MP0008260_abnormal_autophagy	1.00712540
62	MP0002638_abnormal_pupillary_reflex	0.99585441
63	MP0003880_abnormal_central_pattern	0.99226237
64	MP0002006_tumorigenesis	0.98680391
65	MP0002080_prenatal_lethality	0.98024289
66	MP0005319_abnormal_enzyme/_coenzyme	0.97876487
67	MP0005451_abnormal_body_composition	0.97338208
68	MP0006072_abnormal_retinal_apoptosis	0.97098817
69	MP0010307_abnormal_tumor_latency	0.96836161
70	MP0001697_abnormal_embryo_size	0.95664972
71	MP0001853_heart_inflammation	0.95300339
72	MP0000015_abnormal_ear_pigmentation	0.94408238
73	MP0010030_abnormal_orbit_morphology	0.94305148
74	MP0006082_CNS_inflammation	0.92897083
75	MP0005646_abnormal_pituitary_gland	0.92789784
76	MP0001873_stomach_inflammation	0.92595719
77	MP0005025_abnormal_response_to	0.92228456
78	MP0002254_reproductive_system_inflammat	0.90978502
79	MP0008877_abnormal_DNA_methylation	0.90830688
80	MP0005410_abnormal_fertilization	0.90700884
81	MP0000750_abnormal_muscle_regeneration	0.90427365
82	MP0005330_cardiomyopathy	0.87538457
83	MP0005000_abnormal_immune_tolerance	0.86919812
84	MP0005584_abnormal_enzyme/coenzyme_acti	0.86617026
85	MP0002090_abnormal_vision	0.85861047
86	MP0002102_abnormal_ear_morphology	0.85396457
87	MP0008469_abnormal_protein_level	0.85352008
88	MP0002282_abnormal_trachea_morphology	0.85252394
89	MP0000343_altered_response_to	0.85238637
90	MP0006054_spinal_hemorrhage	0.84906473
91	MP0001845_abnormal_inflammatory_respons	0.84863965
92	MP0005083_abnormal_biliary_tract	0.84656176
93	MP0002277_abnormal_respiratory_mucosa	0.84419370
94	MP0005058_abnormal_lysosome_morphology	0.83060309
95	MP0005389_reproductive_system_phenotype	0.81710043
96	MP0002019_abnormal_tumor_incidence	0.81055662
97	MP0001986_abnormal_taste_sensitivity	0.78843825
98	MP0002736_abnormal_nociception_after	0.78199117
99	MP0001661_extended_life_span	0.78020810
100	MP0005165_increased_susceptibility_to	0.77901053
101	MP0002420_abnormal_adaptive_immunity	0.77599108
102	MP0003567_abnormal_fetal_cardiomyocyte	0.76766425
103	MP0001819_abnormal_immune_cell	0.76299097
104	MP0002452_abnormal_antigen_presenting	0.75048015
105	MP0004147_increased_porphyrin_level	0.75018417
106	MP0005376_homeostasis/metabolism_phenot	0.74889964
107	MP0003938_abnormal_ear_development	0.74531297
108	MP0000685_abnormal_immune_system	0.74499712
109	MP0001790_abnormal_immune_system	0.74331036
110	MP0005387_immune_system_phenotype	0.74331036
111	MP0002095_abnormal_skin_pigmentation	0.73760612
112	MP0001672_abnormal_embryogenesis/_devel	0.73497173
113	MP0005380_embryogenesis_phenotype	0.73497173
114	MP0002723_abnormal_immune_serum	0.73082956
115	MP0002139_abnormal_hepatobiliary_system	0.72899195
116	MP0002085_abnormal_embryonic_tissue	0.71854082
117	MP0001929_abnormal_gametogenesis	0.71465717
118	MP0005499_abnormal_olfactory_system	0.71176549
119	MP0005394_taste/olfaction_phenotype	0.71176549
120	MP0001485_abnormal_pinna_reflex	0.70276154
121	MP0002398_abnormal_bone_marrow	0.70205232
122	MP0002877_abnormal_melanocyte_morpholog	0.69689485
123	MP0002148_abnormal_hypersensitivity_rea	0.69628487
124	MP0002210_abnormal_sex_determination	0.69192338
125	MP0000647_abnormal_sebaceous_gland	0.68440676
126	MP0000762_abnormal_tongue_morphology	0.68385647
127	MP0002396_abnormal_hematopoietic_system	0.67538931
128	MP0000516_abnormal_urinary_system	0.67521845
129	MP0005367_renal/urinary_system_phenotyp	0.67521845
130	MP0003950_abnormal_plasma_membrane	0.67444030
131	MP0009763_increased_sensitivity_to	0.67267015
132	MP0005395_other_phenotype	0.67189765
133	MP0005171_absent_coat_pigmentation	0.65844783
134	MP0002332_abnormal_exercise_endurance	0.65835950
135	MP0000049_abnormal_middle_ear	0.65658317
136	MP0002722_abnormal_immune_system	0.64883154
137	MP0001145_abnormal_male_reproductive	0.64078877
138	MP0000689_abnormal_spleen_morphology	0.63030342
139	MP0005409_darkened_coat_color	0.60613130
140	MP0005636_abnormal_mineral_homeostasis	0.60453295
141	MP0003763_abnormal_thymus_physiology	0.59631889
142	MP0002653_abnormal_ependyma_morphology	0.58259312
143	MP0003984_embryonic_growth_retardation	0.57591012
144	MP0008873_increased_physiological_sensi	0.57039491
145	MP0000749_muscle_degeneration	0.54651200
146	MP0002088_abnormal_embryonic_growth/wei	0.54630943
147	MP0000858_altered_metastatic_potential	0.53411839
148	MP0009785_altered_susceptibility_to	0.52458666
149	MP0000703_abnormal_thymus_morphology	0.51241985
150	MP0003890_abnormal_embryonic-extraembry	0.50917671
151	MP0002429_abnormal_blood_cell	0.50829806
152	MP0008872_abnormal_physiological_respon	0.50554953
153	MP0001919_abnormal_reproductive_system	0.49787801

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.83361391
2	Mitochondrial inheritance (HP:0001427)	5.40567761
3	Abnormal mitochondria in muscle tissue (HP:0008316)	5.25095933
4	Abnormality of cells of the erythroid lineage (HP:0012130)	5.22053628
5	Hepatocellular necrosis (HP:0001404)	4.84856061
6	Increased CSF lactate (HP:0002490)	4.78695140
7	Abnormal number of erythroid precursors (HP:0012131)	4.70711101
8	Acute encephalopathy (HP:0006846)	4.67379457
9	Progressive macrocephaly (HP:0004481)	4.65953804
10	Increased hepatocellular lipid droplets (HP:0006565)	4.63535513
11	Increased serum pyruvate (HP:0003542)	4.38853142
12	Abnormality of glycolysis (HP:0004366)	4.38853142
13	Reticulocytopenia (HP:0001896)	4.28670415
14	Hepatic necrosis (HP:0002605)	4.26895448
15	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	4.23011833
16	3-Methylglutaconic aciduria (HP:0003535)	4.13060738
17	Lipid accumulation in hepatocytes (HP:0006561)	4.06186539
18	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	4.00221416
19	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.91432998
20	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.91432998
21	Macrocytic anemia (HP:0001972)	3.78672570
22	Renal Fanconi syndrome (HP:0001994)	3.76201330
23	Increased serum lactate (HP:0002151)	3.65658644
24	Cerebral hypomyelination (HP:0006808)	3.59658631
25	Respiratory failure (HP:0002878)	3.39333400
26	Exercise intolerance (HP:0003546)	3.37765137
27	Cerebral edema (HP:0002181)	3.27759984
28	Increased intramyocellular lipid droplets (HP:0012240)	3.27753881
29	Birth length less than 3rd percentile (HP:0003561)	3.26017037
30	Exertional dyspnea (HP:0002875)	3.25341897
31	Breast hypoplasia (HP:0003187)	3.21443561
32	Lactic acidosis (HP:0003128)	3.12878431
33	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.11702786
34	Abnormal protein N-linked glycosylation (HP:0012347)	3.11702786
35	Abnormal protein glycosylation (HP:0012346)	3.11702786
36	Abnormal glycosylation (HP:0012345)	3.11702786
37	Leukodystrophy (HP:0002415)	3.07455397
38	Pallor (HP:0000980)	3.06242479
39	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.04440995
40	Respiratory difficulties (HP:0002880)	2.87055273
41	Parakeratosis (HP:0001036)	2.80105638
42	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.78216264
43	Reduced antithrombin III activity (HP:0001976)	2.77987986
44	Optic disc pallor (HP:0000543)	2.71446649
45	Increased muscle lipid content (HP:0009058)	2.67606650
46	Oral leukoplakia (HP:0002745)	2.67076225
47	Carpal bone hypoplasia (HP:0001498)	2.58889262
48	Microvesicular hepatic steatosis (HP:0001414)	2.57104794
49	Abnormal gallbladder physiology (HP:0012438)	2.56957872
50	Cholecystitis (HP:0001082)	2.56957872
51	Rough bone trabeculation (HP:0100670)	2.56184975
52	CNS demyelination (HP:0007305)	2.55571209
53	Multiple enchondromatosis (HP:0005701)	2.52793515
54	Emotional lability (HP:0000712)	2.47453352
55	Congenital ichthyosiform erythroderma (HP:0007431)	2.43716980
56	Abnormality of methionine metabolism (HP:0010901)	2.38853791
57	Aplastic anemia (HP:0001915)	2.38538055
58	Type I transferrin isoform profile (HP:0003642)	2.37045963
59	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.35598687
60	Generalized aminoaciduria (HP:0002909)	2.32081239
61	Methylmalonic aciduria (HP:0012120)	2.30503259
62	Hypokinesia (HP:0002375)	2.20667325
63	Secondary amenorrhea (HP:0000869)	2.20499690
64	Trismus (HP:0000211)	2.18566802
65	Abnormality of renal resorption (HP:0011038)	2.17655624
66	Abnormality of placental membranes (HP:0011409)	2.15491176
67	Amniotic constriction ring (HP:0009775)	2.15491176
68	Nausea (HP:0002018)	2.12134604
69	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.11595740
70	Dicarboxylic aciduria (HP:0003215)	2.11595740
71	Abnormality of the preputium (HP:0100587)	2.07442940
72	Neuroendocrine neoplasm (HP:0100634)	2.06157852
73	CNS hypomyelination (HP:0003429)	2.05382556
74	Microretrognathia (HP:0000308)	2.02068638
75	Sparse eyelashes (HP:0000653)	1.97414250
76	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.96713454
77	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.96303461
78	Patellar aplasia (HP:0006443)	1.95501339
79	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.95261287
80	Opisthotonus (HP:0002179)	1.95189383
81	Irregular epiphyses (HP:0010582)	1.94980343
82	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.91962809
83	Premature graying of hair (HP:0002216)	1.91854229
84	Abnormal trabecular bone morphology (HP:0100671)	1.91759087
85	Methylmalonic acidemia (HP:0002912)	1.90360953
86	X-linked dominant inheritance (HP:0001423)	1.90230870
87	Lethargy (HP:0001254)	1.89142151
88	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.88239750
89	Stenosis of the external auditory canal (HP:0000402)	1.87824328
90	Aplasia/Hypoplasia of the patella (HP:0006498)	1.87366720
91	Poor head control (HP:0002421)	1.86942597
92	Ragged-red muscle fibers (HP:0003200)	1.85752955
93	Testicular atrophy (HP:0000029)	1.85564037
94	Abnormality of the axillary hair (HP:0100134)	1.85468826
95	Abnormality of secondary sexual hair (HP:0009888)	1.85468826
96	Absent radius (HP:0003974)	1.85251350
97	Delusions (HP:0000746)	1.85215138
98	Aplasia/hypoplasia of the uterus (HP:0008684)	1.85035812
99	Palpitations (HP:0001962)	1.84792451
100	Horseshoe kidney (HP:0000085)	1.84539707
101	Abnormality of the anterior horn cell (HP:0006802)	1.82423165
102	Degeneration of anterior horn cells (HP:0002398)	1.82423165
103	Abnormality of urine glucose concentration (HP:0011016)	1.82301115
104	Glycosuria (HP:0003076)	1.82301115
105	Petechiae (HP:0000967)	1.82169766
106	Glossoptosis (HP:0000162)	1.82044763
107	Premature ovarian failure (HP:0008209)	1.79937971
108	Absent thumb (HP:0009777)	1.79006987
109	Abnormality of the ileum (HP:0001549)	1.78866982
110	Posterior subcapsular cataract (HP:0007787)	1.77785215
111	Pancytopenia (HP:0001876)	1.77526341
112	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.77194311
113	Abnormality of alanine metabolism (HP:0010916)	1.77194311
114	Hyperalaninemia (HP:0003348)	1.77194311
115	Cleft eyelid (HP:0000625)	1.77160299
116	Congenital, generalized hypertrichosis (HP:0004540)	1.75990713
117	Cellular immunodeficiency (HP:0005374)	1.74907033
118	IgM deficiency (HP:0002850)	1.74485552
119	Aplasia involving forearm bones (HP:0009822)	1.73638394
120	Absent forearm bone (HP:0003953)	1.73638394
121	Progressive external ophthalmoplegia (HP:0000590)	1.73236686
122	Hyperphosphaturia (HP:0003109)	1.73217487
123	Neoplasm of the adrenal gland (HP:0100631)	1.71336165
124	Abnormality of the umbilical cord (HP:0010881)	1.70440806
125	Hepatosplenomegaly (HP:0001433)	1.69619480
126	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.69240791
127	11 pairs of ribs (HP:0000878)	1.68971627
128	Postnatal microcephaly (HP:0005484)	1.68763540
129	Gliosis (HP:0002171)	1.68009214
130	Abnormality of serum amino acid levels (HP:0003112)	1.67521013
131	Spastic paraparesis (HP:0002313)	1.66996317
132	Blindness (HP:0000618)	1.66342799
133	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.65561085
134	Vomiting (HP:0002013)	1.65376947
135	Meckel diverticulum (HP:0002245)	1.65242484
136	Triphalangeal thumb (HP:0001199)	1.64482528
137	Progressive microcephaly (HP:0000253)	1.64086142
138	Abnormality of the fetal cardiovascular system (HP:0010948)	1.63983779
139	Single umbilical artery (HP:0001195)	1.63983779
140	Abnormal pupillary function (HP:0007686)	1.62694582
141	Neutropenia (HP:0001875)	1.61739585

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BUB1	5.21914581
2	VRK2	4.60027047
3	STK16	3.72360077
4	NME2	3.58383396
5	WEE1	3.57084740
6	EIF2AK1	2.95306089
7	NME1	2.87125859
8	TESK2	2.81080055
9	SRPK1	2.64583154
10	TSSK6	2.56472133
11	VRK1	2.53197093
12	PBK	2.30661161
13	EIF2AK3	2.16926172
14	MST4	2.07035495
15	TLK1	1.98137676
16	PIM2	1.95004355
17	PLK4	1.89817779
18	ARAF	1.85893139
19	PNCK	1.65830098
20	LIMK1	1.63987027
21	PDK2	1.61315352
22	NUAK1	1.55860290
23	MAP3K12	1.55584650
24	KDR	1.47377248
25	EPHA2	1.46217777
26	CDC7	1.42981670
27	TRIM28	1.38190088
28	AURKA	1.34209467
29	RPS6KB2	1.32932267
30	TESK1	1.30115335
31	PLK1	1.26242541
32	MYLK	1.24235236
33	SCYL2	1.23806567
34	PLK3	1.22155197
35	MST1R	1.21254293
36	TTK	1.17873242
37	TXK	1.17465269
38	MAP4K2	1.16214497
39	DYRK2	1.15850603
40	BRAF	1.14526254
41	ZAK	1.09633604
42	AURKB	1.03983483
43	ABL2	1.01853651
44	BCR	1.00594942
45	BRSK2	0.99274076
46	ACVR1B	0.96213223
47	NEK1	0.93569913
48	GRK5	0.92338839
49	MKNK1	0.91078005
50	STK24	0.89632920
51	ILK	0.89038473
52	CDK7	0.88951921
53	CDK19	0.86831632
54	BCKDK	0.85604373
55	PAK1	0.83611499
56	GRK7	0.83007411
57	CCNB1	0.82672161
58	ADRBK2	0.81879475
59	MAP3K11	0.81268509
60	GRK6	0.80829313
61	CSNK1A1L	0.80467693
62	BMPR1B	0.79213639
63	TAF1	0.77676450
64	CSNK2A2	0.76512239
65	CSNK2A1	0.76259178
66	BLK	0.76160023
67	DYRK3	0.74432504
68	CHEK2	0.73666163
69	INSRR	0.73142185
70	STK39	0.70779911
71	EIF2AK2	0.70139671
72	PAK4	0.68168173
73	OBSCN	0.67613502
74	LRRK2	0.66712217
75	BRSK1	0.66541075
76	SIK3	0.63279176
77	MAPKAPK3	0.63160945
78	CSNK1G2	0.63114319
79	CASK	0.62753800
80	PRKCI	0.61425801
81	RPS6KA5	0.61189747
82	CSNK1G3	0.60362449
83	ATR	0.59070286
84	PASK	0.58901264
85	GRK1	0.57634791
86	MUSK	0.57617632
87	CDK8	0.57405734
88	ERBB3	0.56869029
89	OXSR1	0.55890180
90	MAP3K8	0.52123616
91	DAPK3	0.50949835
92	IKBKB	0.46127095
93	CLK1	0.43546110
94	MAPKAPK5	0.42506454
95	AKT3	0.41886950
96	IRAK3	0.40618917
97	ADRBK1	0.40188787
98	CHEK1	0.40081393
99	MKNK2	0.39284722
100	DAPK1	0.39019359
101	CAMK2B	0.37936640
102	CDK14	0.36832718
103	WNK3	0.36790187
104	RPS6KA4	0.36316364
105	PIM1	0.36268226
106	YES1	0.35886486
107	STK4	0.35052299
108	CDK11A	0.34906093
109	CDK18	0.34739540
110	FER	0.33656849
111	MAP3K3	0.33066230
112	CDK15	0.32970234
113	TBK1	0.31606793
114	ALK	0.31247270
115	TGFBR1	0.29890939
116	PIK3CG	0.29869359
117	IRAK4	0.26597280
118	TAOK2	0.26521694
119	ROCK2	0.26515492
120	BMPR2	0.26030843
121	CAMK2G	0.25900473
122	NEK2	0.25765802
123	PLK2	0.24973835
124	CSNK1G1	0.24638823
125	LYN	0.24615094
126	STK10	0.24330592
127	PRKCQ	0.23007629

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	* Proteasome_Homo sapiens_hsa03050	5.26756451
2	Ribosome_Homo sapiens_hsa03010	5.08672710
3	Oxidative phosphorylation_Homo sapiens_hsa00190	4.16612868
4	RNA polymerase_Homo sapiens_hsa03020	3.83659723
5	Parkinsons disease_Homo sapiens_hsa05012	3.64837979
6	DNA replication_Homo sapiens_hsa03030	3.07321092
7	Huntingtons disease_Homo sapiens_hsa05016	2.74240086
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.71260087
9	Mismatch repair_Homo sapiens_hsa03430	2.67292857
10	Spliceosome_Homo sapiens_hsa03040	2.52430120
11	Alzheimers disease_Homo sapiens_hsa05010	2.48827473
12	Pyrimidine metabolism_Homo sapiens_hsa00240	2.47843050
13	Protein export_Homo sapiens_hsa03060	2.22441627
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.16109832
15	Nucleotide excision repair_Homo sapiens_hsa03420	2.12840676
16	Homologous recombination_Homo sapiens_hsa03440	2.10928371
17	RNA transport_Homo sapiens_hsa03013	1.90008397
18	Base excision repair_Homo sapiens_hsa03410	1.72052437
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.60684681
20	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.59186948
21	Basal transcription factors_Homo sapiens_hsa03022	1.44776525
22	One carbon pool by folate_Homo sapiens_hsa00670	1.40403047
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.35099234
24	Non-homologous end-joining_Homo sapiens_hsa03450	1.32451938
25	Purine metabolism_Homo sapiens_hsa00230	1.31230684
26	RNA degradation_Homo sapiens_hsa03018	1.31167991
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.23387346
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.22281140
29	Cell cycle_Homo sapiens_hsa04110	1.15843135
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.12960462
31	Glutathione metabolism_Homo sapiens_hsa00480	1.11498062
32	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.05341696
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.04029253
34	Fatty acid elongation_Homo sapiens_hsa00062	0.95693937
35	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.92348583
36	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.91441724
37	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.88884434
38	Folate biosynthesis_Homo sapiens_hsa00790	0.87361910
39	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.85593146
40	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.84140944
41	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.80991801
42	Collecting duct acid secretion_Homo sapiens_hsa04966	0.80661838
43	Pentose phosphate pathway_Homo sapiens_hsa00030	0.80334124
44	Metabolic pathways_Homo sapiens_hsa01100	0.77205377
45	Steroid biosynthesis_Homo sapiens_hsa00100	0.74756736
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.74047025
47	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.71956652
48	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.67776491
49	Sulfur relay system_Homo sapiens_hsa04122	0.67751937
50	Carbon metabolism_Homo sapiens_hsa01200	0.67670269
51	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.66617316
52	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.65687450
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.65031128
54	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.64483644
55	p53 signaling pathway_Homo sapiens_hsa04115	0.63540987
56	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.61771835
57	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.61529180
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.60534044
59	Phenylalanine metabolism_Homo sapiens_hsa00360	0.58599541
60	Tyrosine metabolism_Homo sapiens_hsa00350	0.57898942
61	Caffeine metabolism_Homo sapiens_hsa00232	0.57827495
62	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.55649809
63	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.55107577
64	Linoleic acid metabolism_Homo sapiens_hsa00591	0.53490906
65	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52767521
66	mRNA surveillance pathway_Homo sapiens_hsa03015	0.52057416
67	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51364097
68	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.51049238
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.50119527
70	Regulation of autophagy_Homo sapiens_hsa04140	0.49825700
71	Vibrio cholerae infection_Homo sapiens_hsa05110	0.48834740
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44448080
73	Graft-versus-host disease_Homo sapiens_hsa05332	0.44000174
74	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.43809772
75	Tryptophan metabolism_Homo sapiens_hsa00380	0.43805889
76	Arginine and proline metabolism_Homo sapiens_hsa00330	0.43355113
77	Selenocompound metabolism_Homo sapiens_hsa00450	0.43349167
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.43128773
79	Sulfur metabolism_Homo sapiens_hsa00920	0.40478552
80	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.40276743
81	Butanoate metabolism_Homo sapiens_hsa00650	0.39153291
82	Ether lipid metabolism_Homo sapiens_hsa00565	0.38595995
83	Type I diabetes mellitus_Homo sapiens_hsa04940	0.37166612
84	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.36343932
85	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.35346714
86	Fatty acid degradation_Homo sapiens_hsa00071	0.34879487
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.33201647
88	Antigen processing and presentation_Homo sapiens_hsa04612	0.33145889
89	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.30213050
90	Primary immunodeficiency_Homo sapiens_hsa05340	0.30049486
91	Allograft rejection_Homo sapiens_hsa05330	0.29967186
92	Rheumatoid arthritis_Homo sapiens_hsa05323	0.29780540
93	Chemical carcinogenesis_Homo sapiens_hsa05204	0.26270401
94	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.26059999
95	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.25974786
96	Oocyte meiosis_Homo sapiens_hsa04114	0.25113412
97	beta-Alanine metabolism_Homo sapiens_hsa00410	0.23948779
98	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.23716692
99	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.23428481
100	Asthma_Homo sapiens_hsa05310	0.22832013
101	Histidine metabolism_Homo sapiens_hsa00340	0.22276403
102	Galactose metabolism_Homo sapiens_hsa00052	0.20324731
103	Phagosome_Homo sapiens_hsa04145	0.20260533
104	Alcoholism_Homo sapiens_hsa05034	0.20195807
105	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.19862157
106	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.19800094
107	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.16772100
108	Viral carcinogenesis_Homo sapiens_hsa05203	0.16661087
109	Legionellosis_Homo sapiens_hsa05134	0.15195182
110	Peroxisome_Homo sapiens_hsa04146	0.12624332
111	Sphingolipid metabolism_Homo sapiens_hsa00600	0.11465403
112	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.09525433
113	Shigellosis_Homo sapiens_hsa05131	0.06789612
114	Propanoate metabolism_Homo sapiens_hsa00640	0.06705399
115	Herpes simplex infection_Homo sapiens_hsa05168	0.06634108
116	Other glycan degradation_Homo sapiens_hsa00511	0.05191902
117	Renin-angiotensin system_Homo sapiens_hsa04614	0.03506303

PSMB3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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