PSMB3P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)8.09773567
2regulation of immunoglobulin secretion (GO:0051023)5.70908243
3regulation of regulatory T cell differentiation (GO:0045589)5.61351767
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.25633155
5cytidine deamination (GO:0009972)5.21867767
6cytidine metabolic process (GO:0046087)5.21867767
7cytidine catabolic process (GO:0006216)5.21867767
8positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.92088932
9rRNA modification (GO:0000154)4.73384812
10rRNA methylation (GO:0031167)4.72793842
11pyrimidine ribonucleoside catabolic process (GO:0046133)4.54283118
12regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.28379044
13somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)4.26269671
14somatic diversification of immunoglobulins involved in immune response (GO:0002208)4.26269671
15isotype switching (GO:0045190)4.26269671
16regulation of isotype switching to IgG isotypes (GO:0048302)4.15449616
17proteasome assembly (GO:0043248)3.84123751
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.83694938
19NADH dehydrogenase complex assembly (GO:0010257)3.83694938
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.83694938
21chaperone-mediated protein transport (GO:0072321)3.80288363
22regulation of chronic inflammatory response (GO:0002676)3.72938290
23respiratory chain complex IV assembly (GO:0008535)3.70944615
24maturation of 5.8S rRNA (GO:0000460)3.67003820
25positive regulation of defense response to virus by host (GO:0002230)3.66372661
26protein neddylation (GO:0045116)3.63357422
27protein complex biogenesis (GO:0070271)3.58910960
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.54959556
29positive regulation of prostaglandin secretion (GO:0032308)3.52168959
30mitochondrial respiratory chain complex assembly (GO:0033108)3.51057264
31exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.49413211
32negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.44125231
33negative regulation of T-helper cell differentiation (GO:0045623)3.44125231
34positive regulation of interleukin-17 production (GO:0032740)3.41528765
35nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.40130548
36protein-cofactor linkage (GO:0018065)3.36777469
37DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.33908125
38ATP synthesis coupled proton transport (GO:0015986)3.32472458
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.32472458
40signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.28482028
41signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.28482028
42signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.28482028
43GTP biosynthetic process (GO:0006183)3.26714717
44regulation of cellular amino acid metabolic process (GO:0006521)3.23516456
45signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.22810996
46intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.22810996
47transcription from mitochondrial promoter (GO:0006390)3.20636211
48transcription elongation from RNA polymerase I promoter (GO:0006362)3.14191180
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.11081337
50signal transduction involved in DNA integrity checkpoint (GO:0072401)3.10571622
51signal transduction involved in DNA damage checkpoint (GO:0072422)3.10571622
52UTP metabolic process (GO:0046051)3.08408319
53signal transduction involved in cell cycle checkpoint (GO:0072395)3.08202822
54termination of RNA polymerase I transcription (GO:0006363)3.08076555
55cytochrome complex assembly (GO:0017004)3.06653789
56mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.04919464
57UTP biosynthetic process (GO:0006228)2.99034438
58regulation of cytokine production involved in inflammatory response (GO:1900015)2.97411719
59negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95178209
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.94849859
61negative regulation of B cell apoptotic process (GO:0002903)2.94544650
62ether lipid metabolic process (GO:0046485)2.94423413
63T-helper cell differentiation (GO:0042093)2.88974461
64CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.88974461
65lymph node development (GO:0048535)2.86218018
66somatic recombination of immunoglobulin gene segments (GO:0016447)2.85525845
67somatic diversification of immunoglobulins (GO:0016445)2.85410082
68regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84818217
69regulation of mitotic spindle checkpoint (GO:1903504)2.84818217
70ribosome assembly (GO:0042255)2.83772772
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.80305578
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.79058509
73positive regulation of isotype switching (GO:0045830)2.77260036
74alpha-beta T cell differentiation involved in immune response (GO:0002293)2.76881634
75alpha-beta T cell activation involved in immune response (GO:0002287)2.76881634
76T cell differentiation involved in immune response (GO:0002292)2.76881634
77positive regulation of T-helper 1 type immune response (GO:0002827)2.76733852
78pyrimidine ribonucleoside metabolic process (GO:0046131)2.76243819
79L-fucose catabolic process (GO:0042355)2.75153428
80fucose catabolic process (GO:0019317)2.75153428
81L-fucose metabolic process (GO:0042354)2.75153428
82regulation of prostaglandin secretion (GO:0032306)2.72302051
83mitochondrial RNA metabolic process (GO:0000959)2.72026435
84alpha-beta T cell differentiation (GO:0046632)2.71588398
85negative regulation of thymocyte apoptotic process (GO:0070244)2.69582455
86cellular response to interleukin-15 (GO:0071350)2.69096066
87positive regulation of T cell migration (GO:2000406)2.67329840
88negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.67117482
89negative regulation of ligase activity (GO:0051352)2.67117482
90electron transport chain (GO:0022900)2.67070208
91tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.65462353
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.65462353
93negative regulation of alpha-beta T cell differentiation (GO:0046639)2.63766364
94activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.63673720
95respiratory electron transport chain (GO:0022904)2.62934107
96regulation of thymocyte apoptotic process (GO:0070243)2.62537331
97ribosomal small subunit assembly (GO:0000028)2.61570403
98positive regulation of fatty acid transport (GO:2000193)2.60577878
99regulation of T-helper 1 cell differentiation (GO:0045625)2.60270588
100positive regulation of cell cycle arrest (GO:0071158)2.59754919

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.75701143
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.52515632
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.19639306
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.61065258
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.50839320
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.07172121
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.02638714
8VDR_22108803_ChIP-Seq_LS180_Human2.85043911
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.82893637
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.68472095
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.60853752
12VDR_23849224_ChIP-Seq_CD4+_Human2.54042005
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.51575273
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47184124
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.43667106
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.38875721
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.36330056
18FOXP3_21729870_ChIP-Seq_TREG_Human2.17293832
19ELK1_19687146_ChIP-ChIP_HELA_Human2.15598625
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11843529
21ZNF274_21170338_ChIP-Seq_K562_Hela2.10211370
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.04108435
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01885462
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.96611405
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.87992595
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87968272
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.80230650
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.78523289
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.76777801
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76045558
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.69089881
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65545877
33EWS_26573619_Chip-Seq_HEK293_Human1.65322631
34TP53_22573176_ChIP-Seq_HFKS_Human1.60446507
35IGF1R_20145208_ChIP-Seq_DFB_Human1.59297483
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55194234
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50257027
38MYC_18940864_ChIP-ChIP_HL60_Human1.50063982
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49933923
40IRF1_19129219_ChIP-ChIP_H3396_Human1.47849397
41TAF15_26573619_Chip-Seq_HEK293_Human1.47507451
42DCP1A_22483619_ChIP-Seq_HELA_Human1.46642251
43GATA3_26560356_Chip-Seq_TH2_Human1.44608079
44NANOG_19829295_ChIP-Seq_ESCs_Human1.43137139
45SOX2_19829295_ChIP-Seq_ESCs_Human1.43137139
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.41336834
47RUNX_20019798_ChIP-Seq_JUKART_Human1.38384720
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37604234
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36584787
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35748397
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31535429
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.30862765
53GABP_19822575_ChIP-Seq_HepG2_Human1.28548963
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.22193051
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21346009
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20266982
57MYC_18555785_ChIP-Seq_MESCs_Mouse1.20178157
58TTF2_22483619_ChIP-Seq_HELA_Human1.19219968
59MYB_26560356_Chip-Seq_TH2_Human1.18492855
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.15801011
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15590360
62P300_19829295_ChIP-Seq_ESCs_Human1.14448138
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12364869
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.11201715
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11201715
66GATA3_26560356_Chip-Seq_TH1_Human1.10577217
67TAF2_19829295_ChIP-Seq_ESCs_Human1.09973064
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09918191
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09723786
70TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08044001
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07875006
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06915337
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04434600
74ER_23166858_ChIP-Seq_MCF-7_Human1.03323136
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.02310718
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00725362
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99004780
78AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97666960
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97221091
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97157967
81THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96631460
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95863290
83MYC_19829295_ChIP-Seq_ESCs_Human0.95070106
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94976357
85E2F4_17652178_ChIP-ChIP_JURKAT_Human0.94284412
86SALL4_22934838_ChIP-ChIP_CD34+_Human0.94249198
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94215193
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93842394
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93640159
90CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91591309
91GATA3_27048872_Chip-Seq_THYMUS_Human0.90977638
92HOXB7_26014856_ChIP-Seq_BT474_Human0.90782962
93MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90774580
94AR_20517297_ChIP-Seq_VCAP_Human0.89711445
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88311674
96HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.87374745
97GATA3_21878914_ChIP-Seq_MCF-7_Human0.87135682
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85783484
99SMAD1_18555785_Chip-Seq_ESCs_Mouse0.84222658
100NCOR_22424771_ChIP-Seq_293T_Human0.82894732

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.98961472
2MP0002102_abnormal_ear_morphology3.82344940
3MP0005671_abnormal_response_to3.34952941
4MP0000685_abnormal_immune_system3.05161453
5MP0008875_abnormal_xenobiotic_pharmacok3.03362325
6MP0005387_immune_system_phenotype2.87391675
7MP0001790_abnormal_immune_system2.87391675
8MP0009785_altered_susceptibility_to2.83680025
9MP0002148_abnormal_hypersensitivity_rea2.48575640
10MP0003011_delayed_dark_adaptation2.46067286
11MP0001529_abnormal_vocalization2.39602426
12MP0004147_increased_porphyrin_level2.29822276
13MP0003786_premature_aging2.18187296
14MP0002138_abnormal_hepatobiliary_system2.15668970
15MP0001800_abnormal_humoral_immune2.08236053
16MP0003436_decreased_susceptibility_to1.89499196
17MP0005075_abnormal_melanosome_morpholog1.76084958
18MP0005000_abnormal_immune_tolerance1.74719763
19MP0001348_abnormal_lacrimal_gland1.73390535
20MP0005645_abnormal_hypothalamus_physiol1.72967901
21MP0002933_joint_inflammation1.70986102
22MP0001873_stomach_inflammation1.66503411
23MP0001968_abnormal_touch/_nociception1.63995502
24MP0001501_abnormal_sleep_pattern1.63318455
25MP0005083_abnormal_biliary_tract1.61243533
26MP0004145_abnormal_muscle_electrophysio1.61137209
27MP0000604_amyloidosis1.60967849
28MP0002736_abnormal_nociception_after1.60211090
29MP0003724_increased_susceptibility_to1.59145592
30MP0008995_early_reproductive_senescence1.58742526
31MP0005084_abnormal_gallbladder_morpholo1.58252827
32MP0001853_heart_inflammation1.56131145
33MP0002723_abnormal_immune_serum1.54546711
34MP0001905_abnormal_dopamine_level1.50586053
35MP0006292_abnormal_olfactory_placode1.49190455
36MP0003646_muscle_fatigue1.45770585
37MP0002837_dystrophic_cardiac_calcinosis1.44972086
38MP0008872_abnormal_physiological_respon1.44075580
39MP0001661_extended_life_span1.42182127
40MP0009333_abnormal_splenocyte_physiolog1.41194793
41MP0000372_irregular_coat_pigmentation1.37780426
42MP0003866_abnormal_defecation1.33484931
43MP0002876_abnormal_thyroid_physiology1.32251326
44MP0005379_endocrine/exocrine_gland_phen1.29751939
45MP0002420_abnormal_adaptive_immunity1.26913317
46MP0005025_abnormal_response_to1.24930725
47MP0005551_abnormal_eye_electrophysiolog1.24901675
48MP0004142_abnormal_muscle_tone1.24325599
49MP0001819_abnormal_immune_cell1.23390954
50MP0010155_abnormal_intestine_physiology1.23344097
51MP0006072_abnormal_retinal_apoptosis1.21909748
52MP0002452_abnormal_antigen_presenting1.21529011
53MP0002638_abnormal_pupillary_reflex1.18492640
54MP0002405_respiratory_system_inflammati1.15115398
55MP0002751_abnormal_autonomic_nervous1.13994153
56MP0005646_abnormal_pituitary_gland1.12190103
57MP0003718_maternal_effect1.11912715
58MP0008058_abnormal_DNA_repair1.10017080
59MP0003045_fibrosis1.09338964
60MP0005253_abnormal_eye_physiology1.07929081
61MP0006082_CNS_inflammation1.05387784
62MP0008775_abnormal_heart_ventricle1.00031608
63MP0000689_abnormal_spleen_morphology0.99814116
64MP0001502_abnormal_circadian_rhythm0.98063934
65MP0009764_decreased_sensitivity_to0.97584834
66MP0003252_abnormal_bile_duct0.97401376
67MP0004381_abnormal_hair_follicle0.96483199
68MP0001984_abnormal_olfaction0.95984618
69MP0002095_abnormal_skin_pigmentation0.95328199
70MP0005167_abnormal_blood-brain_barrier0.95201738
71MP0000465_gastrointestinal_hemorrhage0.94357103
72MP0002277_abnormal_respiratory_mucosa0.92899968
73MP0003195_calcinosis0.92710433
74MP0006276_abnormal_autonomic_nervous0.92322692
75MP0001845_abnormal_inflammatory_respons0.91204419
76MP0005636_abnormal_mineral_homeostasis0.91011363
77MP0006036_abnormal_mitochondrial_physio0.90733098
78MP0002234_abnormal_pharynx_morphology0.88885680
79MP0001919_abnormal_reproductive_system0.88413330
80MP0004084_abnormal_cardiac_muscle0.86232752
81MP0004885_abnormal_endolymph0.85445892
82MP0000716_abnormal_immune_system0.84664753
83MP0002722_abnormal_immune_system0.84628476
84MP0002398_abnormal_bone_marrow0.83508425
85MP0008873_increased_physiological_sensi0.81965051
86MP0003329_amyloid_beta_deposits0.77756710
87MP0003186_abnormal_redox_activity0.77268384
88MP0009697_abnormal_copulation0.76621426
89MP0002272_abnormal_nervous_system0.74907656
90MP0000703_abnormal_thymus_morphology0.74410597
91MP0009046_muscle_twitch0.73471499
92MP0005085_abnormal_gallbladder_physiolo0.72495877
93MP0001663_abnormal_digestive_system0.71790198
94MP0006035_abnormal_mitochondrial_morpho0.70733562
95MP0003300_gastrointestinal_ulcer0.70705214
96MP0001533_abnormal_skeleton_physiology0.69351502
97MP0001765_abnormal_ion_homeostasis0.67667913
98MP0003763_abnormal_thymus_physiology0.66297338
99MP0000647_abnormal_sebaceous_gland0.66185680
100MP0005389_reproductive_system_phenotype0.66055439

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.05848085
2Increased IgM level (HP:0003496)5.04497831
3IgG deficiency (HP:0004315)4.44913973
4Acute necrotizing encephalopathy (HP:0006965)4.42595686
5Increased CSF lactate (HP:0002490)4.13199900
6Mitochondrial inheritance (HP:0001427)4.06216722
7Acute encephalopathy (HP:0006846)3.88808457
8Abnormal mitochondria in muscle tissue (HP:0008316)3.83249330
9Hepatocellular necrosis (HP:0001404)3.80409376
10Molar tooth sign on MRI (HP:0002419)3.68217061
11Abnormality of midbrain morphology (HP:0002418)3.68217061
12Progressive macrocephaly (HP:0004481)3.63459386
13Hepatic necrosis (HP:0002605)3.63286128
14Retinal dysplasia (HP:0007973)3.36959284
15Type II lissencephaly (HP:0007260)3.29146186
16Renal cortical cysts (HP:0000803)3.27005985
17Abnormality of T cell physiology (HP:0011840)3.25472956
18Increased hepatocellular lipid droplets (HP:0006565)3.13680440
19Lipid accumulation in hepatocytes (HP:0006561)3.13523368
20Congenital stationary night blindness (HP:0007642)3.12685438
213-Methylglutaconic aciduria (HP:0003535)3.07280068
22Cerebral edema (HP:0002181)3.00412438
23Abnormality of T cells (HP:0002843)2.92112705
24Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.85267037
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.75523543
26Abnormality of alanine metabolism (HP:0010916)2.75523543
27Hyperalaninemia (HP:0003348)2.75523543
28Abnormality of the renal cortex (HP:0011035)2.74901157
29IgA deficiency (HP:0002720)2.71560408
30Nephronophthisis (HP:0000090)2.66272398
31Abnormality of T cell number (HP:0011839)2.59385406
32Increased serum lactate (HP:0002151)2.58808871
33Optic disc pallor (HP:0000543)2.50325319
34Metaphyseal dysplasia (HP:0100255)2.50266960
35T lymphocytopenia (HP:0005403)2.49291221
36Elevated erythrocyte sedimentation rate (HP:0003565)2.46986105
37Abolished electroretinogram (ERG) (HP:0000550)2.44835601
38Hypoplasia of the pons (HP:0012110)2.41739917
39Pancreatic cysts (HP:0001737)2.38680222
40Parakeratosis (HP:0001036)2.38514467
41Aplastic anemia (HP:0001915)2.38081741
42Abnormality of the pons (HP:0007361)2.31824596
43Lactic acidosis (HP:0003128)2.31479017
44Severe combined immunodeficiency (HP:0004430)2.31237823
45Methylmalonic aciduria (HP:0012120)2.31027487
46Methylmalonic acidemia (HP:0002912)2.27157538
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.24790740
48Hypoproteinemia (HP:0003075)2.23596819
49Thyroiditis (HP:0100646)2.18203876
50Myositis (HP:0100614)2.14463365
51Progressive microcephaly (HP:0000253)2.14261217
52Congenital, generalized hypertrichosis (HP:0004540)2.12614646
53Respiratory failure (HP:0002878)2.10438821
54Renal Fanconi syndrome (HP:0001994)2.09039340
55Lethargy (HP:0001254)2.08565285
56Abnormality of the renal medulla (HP:0100957)2.08081729
57Leukodystrophy (HP:0002415)2.05833142
58Generalized aminoaciduria (HP:0002909)2.03359079
59Abnormality of the fovea (HP:0000493)2.02907349
60Abnormal rod and cone electroretinograms (HP:0008323)2.00361736
61Hypoplasia of the fovea (HP:0007750)2.00050592
62Aplasia/Hypoplasia of the fovea (HP:0008060)2.00050592
63Abnormality of the prostate (HP:0008775)1.96989446
64Abnormality of eosinophils (HP:0001879)1.94526590
65Erythroderma (HP:0001019)1.93904872
66CNS demyelination (HP:0007305)1.92121833
67Chronic hepatic failure (HP:0100626)1.91136341
68Autoimmune thrombocytopenia (HP:0001973)1.88242196
69Exertional dyspnea (HP:0002875)1.86781479
70Median cleft lip (HP:0000161)1.85943181
71Cerebellar dysplasia (HP:0007033)1.85611703
72Cleft eyelid (HP:0000625)1.85556886
73Pendular nystagmus (HP:0012043)1.84298534
74Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83988752
75Retrobulbar optic neuritis (HP:0100654)1.83975114
76Optic neuritis (HP:0100653)1.83975114
77Recurrent cutaneous fungal infections (HP:0011370)1.83010269
78Chronic mucocutaneous candidiasis (HP:0002728)1.83010269
79Dicarboxylic aciduria (HP:0003215)1.82049539
80Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82049539
81Abnormality of B cell number (HP:0010975)1.81616541
82Abnormality of the nasal septum (HP:0000419)1.81575813
83Exercise intolerance (HP:0003546)1.78632191
84Neutropenia (HP:0001875)1.78332705
85Carpal bone hypoplasia (HP:0001498)1.77879188
86Hypergammaglobulinemia (HP:0010702)1.74228053
87Adactyly (HP:0009776)1.73811335
88Panhypogammaglobulinemia (HP:0003139)1.73515961
89Opisthotonus (HP:0002179)1.71259766
90Pancytopenia (HP:0001876)1.71007706
91True hermaphroditism (HP:0010459)1.70152494
92Increased intramyocellular lipid droplets (HP:0012240)1.69672919
93Increased serum pyruvate (HP:0003542)1.67170073
94Increased corneal curvature (HP:0100692)1.66481212
95Keratoconus (HP:0000563)1.66481212
96Chronic sinusitis (HP:0011109)1.66352799
97Muscle fiber atrophy (HP:0100295)1.65242117
98Reduced antithrombin III activity (HP:0001976)1.64248157
99Attenuation of retinal blood vessels (HP:0007843)1.63421740
100Respiratory difficulties (HP:0002880)1.62604661

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME13.63648736
2MST43.32115683
3ZAK3.25412718
4ADRBK23.12412652
5BCKDK2.97075064
6TXK2.75904391
7VRK22.61001102
8MAP4K22.45024339
9TSSK62.38078364
10EIF2AK32.35481285
11TIE12.33375687
12NUAK12.29990820
13TLK12.19493928
14BMPR1B2.15524874
15GRK11.96825325
16NEK11.85904888
17TAF11.80632159
18INSRR1.79866707
19DAPK21.79455939
20DAPK11.71818157
21VRK11.65887875
22DYRK21.60503187
23WNK41.57960143
24TRIM281.54686957
25FRK1.53421845
26MAPKAPK31.51512830
27ACVR1B1.44066552
28PHKG21.39722495
29PHKG11.39722495
30TAOK31.37962534
31CSNK1A1L1.34681079
32CSNK1G31.21768638
33PLK31.15201554
34MAP4K11.14560009
35PINK11.13202390
36SRPK11.12685870
37CSNK1G21.12072107
38OXSR11.08303477
39PLK21.06405912
40EIF2AK21.06244937
41TEC1.03412074
42IKBKB0.97498220
43MAP2K60.96976184
44KIT0.92329059
45FLT30.89660557
46CSNK1G10.88214885
47PAK30.83737550
48LCK0.80919210
49PAK60.80337251
50ITK0.75646588
51WNK30.74882161
52SYK0.74700463
53MKNK10.73948417
54GRK50.71635121
55KDR0.68094205
56IKBKE0.67480279
57PRKCQ0.65943642
58BCR0.63462253
59EPHA30.62930992
60CASK0.62917754
61EIF2AK10.62178592
62RPS6KA50.59669865
63CSF1R0.58860759
64MAPKAPK50.58331971
65GRK70.58013557
66LYN0.57438099
67CDK190.56574355
68MAP3K120.56402946
69TBK10.55957175
70TGFBR10.55150390
71FES0.53873159
72STK390.52607797
73BTK0.51358604
74MATK0.48049201
75DAPK30.47951979
76PLK40.46977691
77ADRBK10.46748725
78CHUK0.46197541
79MKNK20.44948755
80SIK30.44041585
81MAP2K20.43730805
82IGF1R0.40963681
83STK160.40878396
84PDK20.39754378
85RPS6KA40.38582014
86ERBB30.36842935
87PRKCG0.36443804
88PRKCH0.36382542
89ALK0.36097903
90GRK60.35317027
91ATR0.35163864
92STK40.34337769
93CSNK1D0.31558083
94CSNK2A20.31238578
95JAK30.30985990
96CSNK1A10.30614224
97OBSCN0.30128167
98MAP3K40.29717696
99CSNK2A10.29691132
100EGFR0.29682715

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.77558877
2Primary immunodeficiency_Homo sapiens_hsa053403.23434652
3Protein export_Homo sapiens_hsa030602.93442596
4Asthma_Homo sapiens_hsa053102.85253387
5Oxidative phosphorylation_Homo sapiens_hsa001902.78536414
6Autoimmune thyroid disease_Homo sapiens_hsa053202.66064260
7Allograft rejection_Homo sapiens_hsa053302.61455350
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.56042763
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.42379636
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.38152754
11Parkinsons disease_Homo sapiens_hsa050122.37992099
12Caffeine metabolism_Homo sapiens_hsa002322.35356453
13Ribosome_Homo sapiens_hsa030102.25964461
14RNA polymerase_Homo sapiens_hsa030202.25250382
15Basal transcription factors_Homo sapiens_hsa030222.23917401
16RNA degradation_Homo sapiens_hsa030181.90915556
17Type I diabetes mellitus_Homo sapiens_hsa049401.83116063
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.75467571
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64854776
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63786312
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63702849
22Graft-versus-host disease_Homo sapiens_hsa053321.59940463
23Homologous recombination_Homo sapiens_hsa034401.58417655
24Alzheimers disease_Homo sapiens_hsa050101.54236622
25Huntingtons disease_Homo sapiens_hsa050161.53784634
26Nucleotide excision repair_Homo sapiens_hsa034201.37536710
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35453198
28Rheumatoid arthritis_Homo sapiens_hsa053231.35318288
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.34395841
30Hematopoietic cell lineage_Homo sapiens_hsa046401.33259762
31Fanconi anemia pathway_Homo sapiens_hsa034601.22876642
32Propanoate metabolism_Homo sapiens_hsa006401.22485269
33One carbon pool by folate_Homo sapiens_hsa006701.21753164
34Base excision repair_Homo sapiens_hsa034101.20809679
35Tryptophan metabolism_Homo sapiens_hsa003801.18895626
36Peroxisome_Homo sapiens_hsa041461.17209301
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16767761
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.14307833
39Sulfur metabolism_Homo sapiens_hsa009201.08146544
40Pyrimidine metabolism_Homo sapiens_hsa002401.07717879
41T cell receptor signaling pathway_Homo sapiens_hsa046600.99523409
42RNA transport_Homo sapiens_hsa030130.98729011
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98435826
44Linoleic acid metabolism_Homo sapiens_hsa005910.97691874
45Mismatch repair_Homo sapiens_hsa034300.95211074
46Vitamin B6 metabolism_Homo sapiens_hsa007500.94593674
47Purine metabolism_Homo sapiens_hsa002300.93612894
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.92089038
49Phototransduction_Homo sapiens_hsa047440.88061318
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87027221
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86190606
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85784037
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85769582
54Spliceosome_Homo sapiens_hsa030400.85446972
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78440806
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77434869
57Folate biosynthesis_Homo sapiens_hsa007900.76948546
58Measles_Homo sapiens_hsa051620.73289108
59Cardiac muscle contraction_Homo sapiens_hsa042600.72303083
60Antigen processing and presentation_Homo sapiens_hsa046120.71846358
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70341718
62Retinol metabolism_Homo sapiens_hsa008300.67481255
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67034536
64Regulation of autophagy_Homo sapiens_hsa041400.66968476
65Sulfur relay system_Homo sapiens_hsa041220.65081293
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64405074
67Taste transduction_Homo sapiens_hsa047420.63866484
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63510209
69Nitrogen metabolism_Homo sapiens_hsa009100.59583960
70Arachidonic acid metabolism_Homo sapiens_hsa005900.56713638
71Viral myocarditis_Homo sapiens_hsa054160.55289887
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.54843535
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.54362322
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53810092
75Ether lipid metabolism_Homo sapiens_hsa005650.53337356
76Metabolic pathways_Homo sapiens_hsa011000.51866261
77Epstein-Barr virus infection_Homo sapiens_hsa051690.50716732
78Chemical carcinogenesis_Homo sapiens_hsa052040.49751780
79Collecting duct acid secretion_Homo sapiens_hsa049660.48262855
80Butanoate metabolism_Homo sapiens_hsa006500.46719609
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.46358742
82Apoptosis_Homo sapiens_hsa042100.43644597
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41549615
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40602193
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39824033
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38016943
87DNA replication_Homo sapiens_hsa030300.37997266
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35108434
89Selenocompound metabolism_Homo sapiens_hsa004500.34817972
90Olfactory transduction_Homo sapiens_hsa047400.33292663
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.32689196
92Systemic lupus erythematosus_Homo sapiens_hsa053220.31515094
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30970978
94Circadian rhythm_Homo sapiens_hsa047100.27087276
95Herpes simplex infection_Homo sapiens_hsa051680.26090019
96beta-Alanine metabolism_Homo sapiens_hsa004100.25832608
97Legionellosis_Homo sapiens_hsa051340.25150180
98Pyruvate metabolism_Homo sapiens_hsa006200.25118358
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.24741089
100Fatty acid degradation_Homo sapiens_hsa000710.24047022

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