

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 8.09773567 |
| 2 | regulation of immunoglobulin secretion (GO:0051023) | 5.70908243 |
| 3 | regulation of regulatory T cell differentiation (GO:0045589) | 5.61351767 |
| 4 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 5.25633155 |
| 5 | cytidine deamination (GO:0009972) | 5.21867767 |
| 6 | cytidine metabolic process (GO:0046087) | 5.21867767 |
| 7 | cytidine catabolic process (GO:0006216) | 5.21867767 |
| 8 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 4.92088932 |
| 9 | rRNA modification (GO:0000154) | 4.73384812 |
| 10 | rRNA methylation (GO:0031167) | 4.72793842 |
| 11 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 4.54283118 |
| 12 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 4.28379044 |
| 13 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 4.26269671 |
| 14 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 4.26269671 |
| 15 | isotype switching (GO:0045190) | 4.26269671 |
| 16 | regulation of isotype switching to IgG isotypes (GO:0048302) | 4.15449616 |
| 17 | proteasome assembly (GO:0043248) | 3.84123751 |
| 18 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.83694938 |
| 19 | NADH dehydrogenase complex assembly (GO:0010257) | 3.83694938 |
| 20 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.83694938 |
| 21 | chaperone-mediated protein transport (GO:0072321) | 3.80288363 |
| 22 | regulation of chronic inflammatory response (GO:0002676) | 3.72938290 |
| 23 | respiratory chain complex IV assembly (GO:0008535) | 3.70944615 |
| 24 | maturation of 5.8S rRNA (GO:0000460) | 3.67003820 |
| 25 | positive regulation of defense response to virus by host (GO:0002230) | 3.66372661 |
| 26 | protein neddylation (GO:0045116) | 3.63357422 |
| 27 | protein complex biogenesis (GO:0070271) | 3.58910960 |
| 28 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.54959556 |
| 29 | positive regulation of prostaglandin secretion (GO:0032308) | 3.52168959 |
| 30 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.51057264 |
| 31 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.49413211 |
| 32 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 3.44125231 |
| 33 | negative regulation of T-helper cell differentiation (GO:0045623) | 3.44125231 |
| 34 | positive regulation of interleukin-17 production (GO:0032740) | 3.41528765 |
| 35 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.40130548 |
| 36 | protein-cofactor linkage (GO:0018065) | 3.36777469 |
| 37 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.33908125 |
| 38 | ATP synthesis coupled proton transport (GO:0015986) | 3.32472458 |
| 39 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.32472458 |
| 40 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.28482028 |
| 41 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.28482028 |
| 42 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.28482028 |
| 43 | GTP biosynthetic process (GO:0006183) | 3.26714717 |
| 44 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.23516456 |
| 45 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.22810996 |
| 46 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.22810996 |
| 47 | transcription from mitochondrial promoter (GO:0006390) | 3.20636211 |
| 48 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.14191180 |
| 49 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.11081337 |
| 50 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.10571622 |
| 51 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.10571622 |
| 52 | UTP metabolic process (GO:0046051) | 3.08408319 |
| 53 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.08202822 |
| 54 | termination of RNA polymerase I transcription (GO:0006363) | 3.08076555 |
| 55 | cytochrome complex assembly (GO:0017004) | 3.06653789 |
| 56 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.04919464 |
| 57 | UTP biosynthetic process (GO:0006228) | 2.99034438 |
| 58 | regulation of cytokine production involved in inflammatory response (GO:1900015) | 2.97411719 |
| 59 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 2.95178209 |
| 60 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.94849859 |
| 61 | negative regulation of B cell apoptotic process (GO:0002903) | 2.94544650 |
| 62 | ether lipid metabolic process (GO:0046485) | 2.94423413 |
| 63 | T-helper cell differentiation (GO:0042093) | 2.88974461 |
| 64 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 2.88974461 |
| 65 | lymph node development (GO:0048535) | 2.86218018 |
| 66 | somatic recombination of immunoglobulin gene segments (GO:0016447) | 2.85525845 |
| 67 | somatic diversification of immunoglobulins (GO:0016445) | 2.85410082 |
| 68 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.84818217 |
| 69 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.84818217 |
| 70 | ribosome assembly (GO:0042255) | 2.83772772 |
| 71 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.80305578 |
| 72 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.79058509 |
| 73 | positive regulation of isotype switching (GO:0045830) | 2.77260036 |
| 74 | alpha-beta T cell differentiation involved in immune response (GO:0002293) | 2.76881634 |
| 75 | alpha-beta T cell activation involved in immune response (GO:0002287) | 2.76881634 |
| 76 | T cell differentiation involved in immune response (GO:0002292) | 2.76881634 |
| 77 | positive regulation of T-helper 1 type immune response (GO:0002827) | 2.76733852 |
| 78 | pyrimidine ribonucleoside metabolic process (GO:0046131) | 2.76243819 |
| 79 | L-fucose catabolic process (GO:0042355) | 2.75153428 |
| 80 | fucose catabolic process (GO:0019317) | 2.75153428 |
| 81 | L-fucose metabolic process (GO:0042354) | 2.75153428 |
| 82 | regulation of prostaglandin secretion (GO:0032306) | 2.72302051 |
| 83 | mitochondrial RNA metabolic process (GO:0000959) | 2.72026435 |
| 84 | alpha-beta T cell differentiation (GO:0046632) | 2.71588398 |
| 85 | negative regulation of thymocyte apoptotic process (GO:0070244) | 2.69582455 |
| 86 | cellular response to interleukin-15 (GO:0071350) | 2.69096066 |
| 87 | positive regulation of T cell migration (GO:2000406) | 2.67329840 |
| 88 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.67117482 |
| 89 | negative regulation of ligase activity (GO:0051352) | 2.67117482 |
| 90 | electron transport chain (GO:0022900) | 2.67070208 |
| 91 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.65462353 |
| 92 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.65462353 |
| 93 | negative regulation of alpha-beta T cell differentiation (GO:0046639) | 2.63766364 |
| 94 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO | 2.63673720 |
| 95 | respiratory electron transport chain (GO:0022904) | 2.62934107 |
| 96 | regulation of thymocyte apoptotic process (GO:0070243) | 2.62537331 |
| 97 | ribosomal small subunit assembly (GO:0000028) | 2.61570403 |
| 98 | positive regulation of fatty acid transport (GO:2000193) | 2.60577878 |
| 99 | regulation of T-helper 1 cell differentiation (GO:0045625) | 2.60270588 |
| 100 | positive regulation of cell cycle arrest (GO:0071158) | 2.59754919 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.75701143 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.52515632 |
| 3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.19639306 |
| 4 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.61065258 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.50839320 |
| 6 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.07172121 |
| 7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.02638714 |
| 8 | VDR_22108803_ChIP-Seq_LS180_Human | 2.85043911 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.82893637 |
| 10 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.68472095 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.60853752 |
| 12 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.54042005 |
| 13 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.51575273 |
| 14 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.47184124 |
| 15 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.43667106 |
| 16 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.38875721 |
| 17 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.36330056 |
| 18 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.17293832 |
| 19 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.15598625 |
| 20 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.11843529 |
| 21 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.10211370 |
| 22 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.04108435 |
| 23 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.01885462 |
| 24 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.96611405 |
| 25 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.87992595 |
| 26 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.87968272 |
| 27 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.80230650 |
| 28 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.78523289 |
| 29 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.76777801 |
| 30 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.76045558 |
| 31 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.69089881 |
| 32 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.65545877 |
| 33 | EWS_26573619_Chip-Seq_HEK293_Human | 1.65322631 |
| 34 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.60446507 |
| 35 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.59297483 |
| 36 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.55194234 |
| 37 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.50257027 |
| 38 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.50063982 |
| 39 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.49933923 |
| 40 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.47849397 |
| 41 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.47507451 |
| 42 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.46642251 |
| 43 | GATA3_26560356_Chip-Seq_TH2_Human | 1.44608079 |
| 44 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.43137139 |
| 45 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.43137139 |
| 46 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.41336834 |
| 47 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.38384720 |
| 48 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.37604234 |
| 49 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.36584787 |
| 50 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.35748397 |
| 51 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.31535429 |
| 52 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.30862765 |
| 53 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.28548963 |
| 54 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.22193051 |
| 55 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.21346009 |
| 56 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.20266982 |
| 57 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.20178157 |
| 58 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.19219968 |
| 59 | MYB_26560356_Chip-Seq_TH2_Human | 1.18492855 |
| 60 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.15801011 |
| 61 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.15590360 |
| 62 | P300_19829295_ChIP-Seq_ESCs_Human | 1.14448138 |
| 63 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.12364869 |
| 64 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.11201715 |
| 65 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.11201715 |
| 66 | GATA3_26560356_Chip-Seq_TH1_Human | 1.10577217 |
| 67 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.09973064 |
| 68 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.09918191 |
| 69 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.09723786 |
| 70 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.08044001 |
| 71 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.07875006 |
| 72 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.06915337 |
| 73 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.04434600 |
| 74 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.03323136 |
| 75 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.02310718 |
| 76 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.00725362 |
| 77 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.99004780 |
| 78 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.97666960 |
| 79 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.97221091 |
| 80 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.97157967 |
| 81 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 0.96631460 |
| 82 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.95863290 |
| 83 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.95070106 |
| 84 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.94976357 |
| 85 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 0.94284412 |
| 86 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.94249198 |
| 87 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.94215193 |
| 88 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.93842394 |
| 89 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.93640159 |
| 90 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.91591309 |
| 91 | GATA3_27048872_Chip-Seq_THYMUS_Human | 0.90977638 |
| 92 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.90782962 |
| 93 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.90774580 |
| 94 | AR_20517297_ChIP-Seq_VCAP_Human | 0.89711445 |
| 95 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.88311674 |
| 96 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.87374745 |
| 97 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.87135682 |
| 98 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.85783484 |
| 99 | SMAD1_18555785_Chip-Seq_ESCs_Mouse | 0.84222658 |
| 100 | NCOR_22424771_ChIP-Seq_293T_Human | 0.82894732 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 3.98961472 |
| 2 | MP0002102_abnormal_ear_morphology | 3.82344940 |
| 3 | MP0005671_abnormal_response_to | 3.34952941 |
| 4 | MP0000685_abnormal_immune_system | 3.05161453 |
| 5 | MP0008875_abnormal_xenobiotic_pharmacok | 3.03362325 |
| 6 | MP0005387_immune_system_phenotype | 2.87391675 |
| 7 | MP0001790_abnormal_immune_system | 2.87391675 |
| 8 | MP0009785_altered_susceptibility_to | 2.83680025 |
| 9 | MP0002148_abnormal_hypersensitivity_rea | 2.48575640 |
| 10 | MP0003011_delayed_dark_adaptation | 2.46067286 |
| 11 | MP0001529_abnormal_vocalization | 2.39602426 |
| 12 | MP0004147_increased_porphyrin_level | 2.29822276 |
| 13 | MP0003786_premature_aging | 2.18187296 |
| 14 | MP0002138_abnormal_hepatobiliary_system | 2.15668970 |
| 15 | MP0001800_abnormal_humoral_immune | 2.08236053 |
| 16 | MP0003436_decreased_susceptibility_to | 1.89499196 |
| 17 | MP0005075_abnormal_melanosome_morpholog | 1.76084958 |
| 18 | MP0005000_abnormal_immune_tolerance | 1.74719763 |
| 19 | MP0001348_abnormal_lacrimal_gland | 1.73390535 |
| 20 | MP0005645_abnormal_hypothalamus_physiol | 1.72967901 |
| 21 | MP0002933_joint_inflammation | 1.70986102 |
| 22 | MP0001873_stomach_inflammation | 1.66503411 |
| 23 | MP0001968_abnormal_touch/_nociception | 1.63995502 |
| 24 | MP0001501_abnormal_sleep_pattern | 1.63318455 |
| 25 | MP0005083_abnormal_biliary_tract | 1.61243533 |
| 26 | MP0004145_abnormal_muscle_electrophysio | 1.61137209 |
| 27 | MP0000604_amyloidosis | 1.60967849 |
| 28 | MP0002736_abnormal_nociception_after | 1.60211090 |
| 29 | MP0003724_increased_susceptibility_to | 1.59145592 |
| 30 | MP0008995_early_reproductive_senescence | 1.58742526 |
| 31 | MP0005084_abnormal_gallbladder_morpholo | 1.58252827 |
| 32 | MP0001853_heart_inflammation | 1.56131145 |
| 33 | MP0002723_abnormal_immune_serum | 1.54546711 |
| 34 | MP0001905_abnormal_dopamine_level | 1.50586053 |
| 35 | MP0006292_abnormal_olfactory_placode | 1.49190455 |
| 36 | MP0003646_muscle_fatigue | 1.45770585 |
| 37 | MP0002837_dystrophic_cardiac_calcinosis | 1.44972086 |
| 38 | MP0008872_abnormal_physiological_respon | 1.44075580 |
| 39 | MP0001661_extended_life_span | 1.42182127 |
| 40 | MP0009333_abnormal_splenocyte_physiolog | 1.41194793 |
| 41 | MP0000372_irregular_coat_pigmentation | 1.37780426 |
| 42 | MP0003866_abnormal_defecation | 1.33484931 |
| 43 | MP0002876_abnormal_thyroid_physiology | 1.32251326 |
| 44 | MP0005379_endocrine/exocrine_gland_phen | 1.29751939 |
| 45 | MP0002420_abnormal_adaptive_immunity | 1.26913317 |
| 46 | MP0005025_abnormal_response_to | 1.24930725 |
| 47 | MP0005551_abnormal_eye_electrophysiolog | 1.24901675 |
| 48 | MP0004142_abnormal_muscle_tone | 1.24325599 |
| 49 | MP0001819_abnormal_immune_cell | 1.23390954 |
| 50 | MP0010155_abnormal_intestine_physiology | 1.23344097 |
| 51 | MP0006072_abnormal_retinal_apoptosis | 1.21909748 |
| 52 | MP0002452_abnormal_antigen_presenting | 1.21529011 |
| 53 | MP0002638_abnormal_pupillary_reflex | 1.18492640 |
| 54 | MP0002405_respiratory_system_inflammati | 1.15115398 |
| 55 | MP0002751_abnormal_autonomic_nervous | 1.13994153 |
| 56 | MP0005646_abnormal_pituitary_gland | 1.12190103 |
| 57 | MP0003718_maternal_effect | 1.11912715 |
| 58 | MP0008058_abnormal_DNA_repair | 1.10017080 |
| 59 | MP0003045_fibrosis | 1.09338964 |
| 60 | MP0005253_abnormal_eye_physiology | 1.07929081 |
| 61 | MP0006082_CNS_inflammation | 1.05387784 |
| 62 | MP0008775_abnormal_heart_ventricle | 1.00031608 |
| 63 | MP0000689_abnormal_spleen_morphology | 0.99814116 |
| 64 | MP0001502_abnormal_circadian_rhythm | 0.98063934 |
| 65 | MP0009764_decreased_sensitivity_to | 0.97584834 |
| 66 | MP0003252_abnormal_bile_duct | 0.97401376 |
| 67 | MP0004381_abnormal_hair_follicle | 0.96483199 |
| 68 | MP0001984_abnormal_olfaction | 0.95984618 |
| 69 | MP0002095_abnormal_skin_pigmentation | 0.95328199 |
| 70 | MP0005167_abnormal_blood-brain_barrier | 0.95201738 |
| 71 | MP0000465_gastrointestinal_hemorrhage | 0.94357103 |
| 72 | MP0002277_abnormal_respiratory_mucosa | 0.92899968 |
| 73 | MP0003195_calcinosis | 0.92710433 |
| 74 | MP0006276_abnormal_autonomic_nervous | 0.92322692 |
| 75 | MP0001845_abnormal_inflammatory_respons | 0.91204419 |
| 76 | MP0005636_abnormal_mineral_homeostasis | 0.91011363 |
| 77 | MP0006036_abnormal_mitochondrial_physio | 0.90733098 |
| 78 | MP0002234_abnormal_pharynx_morphology | 0.88885680 |
| 79 | MP0001919_abnormal_reproductive_system | 0.88413330 |
| 80 | MP0004084_abnormal_cardiac_muscle | 0.86232752 |
| 81 | MP0004885_abnormal_endolymph | 0.85445892 |
| 82 | MP0000716_abnormal_immune_system | 0.84664753 |
| 83 | MP0002722_abnormal_immune_system | 0.84628476 |
| 84 | MP0002398_abnormal_bone_marrow | 0.83508425 |
| 85 | MP0008873_increased_physiological_sensi | 0.81965051 |
| 86 | MP0003329_amyloid_beta_deposits | 0.77756710 |
| 87 | MP0003186_abnormal_redox_activity | 0.77268384 |
| 88 | MP0009697_abnormal_copulation | 0.76621426 |
| 89 | MP0002272_abnormal_nervous_system | 0.74907656 |
| 90 | MP0000703_abnormal_thymus_morphology | 0.74410597 |
| 91 | MP0009046_muscle_twitch | 0.73471499 |
| 92 | MP0005085_abnormal_gallbladder_physiolo | 0.72495877 |
| 93 | MP0001663_abnormal_digestive_system | 0.71790198 |
| 94 | MP0006035_abnormal_mitochondrial_morpho | 0.70733562 |
| 95 | MP0003300_gastrointestinal_ulcer | 0.70705214 |
| 96 | MP0001533_abnormal_skeleton_physiology | 0.69351502 |
| 97 | MP0001765_abnormal_ion_homeostasis | 0.67667913 |
| 98 | MP0003763_abnormal_thymus_physiology | 0.66297338 |
| 99 | MP0000647_abnormal_sebaceous_gland | 0.66185680 |
| 100 | MP0005389_reproductive_system_phenotype | 0.66055439 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Stomatitis (HP:0010280) | 6.05848085 |
| 2 | Increased IgM level (HP:0003496) | 5.04497831 |
| 3 | IgG deficiency (HP:0004315) | 4.44913973 |
| 4 | Acute necrotizing encephalopathy (HP:0006965) | 4.42595686 |
| 5 | Increased CSF lactate (HP:0002490) | 4.13199900 |
| 6 | Mitochondrial inheritance (HP:0001427) | 4.06216722 |
| 7 | Acute encephalopathy (HP:0006846) | 3.88808457 |
| 8 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.83249330 |
| 9 | Hepatocellular necrosis (HP:0001404) | 3.80409376 |
| 10 | Molar tooth sign on MRI (HP:0002419) | 3.68217061 |
| 11 | Abnormality of midbrain morphology (HP:0002418) | 3.68217061 |
| 12 | Progressive macrocephaly (HP:0004481) | 3.63459386 |
| 13 | Hepatic necrosis (HP:0002605) | 3.63286128 |
| 14 | Retinal dysplasia (HP:0007973) | 3.36959284 |
| 15 | Type II lissencephaly (HP:0007260) | 3.29146186 |
| 16 | Renal cortical cysts (HP:0000803) | 3.27005985 |
| 17 | Abnormality of T cell physiology (HP:0011840) | 3.25472956 |
| 18 | Increased hepatocellular lipid droplets (HP:0006565) | 3.13680440 |
| 19 | Lipid accumulation in hepatocytes (HP:0006561) | 3.13523368 |
| 20 | Congenital stationary night blindness (HP:0007642) | 3.12685438 |
| 21 | 3-Methylglutaconic aciduria (HP:0003535) | 3.07280068 |
| 22 | Cerebral edema (HP:0002181) | 3.00412438 |
| 23 | Abnormality of T cells (HP:0002843) | 2.92112705 |
| 24 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.85267037 |
| 25 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.75523543 |
| 26 | Abnormality of alanine metabolism (HP:0010916) | 2.75523543 |
| 27 | Hyperalaninemia (HP:0003348) | 2.75523543 |
| 28 | Abnormality of the renal cortex (HP:0011035) | 2.74901157 |
| 29 | IgA deficiency (HP:0002720) | 2.71560408 |
| 30 | Nephronophthisis (HP:0000090) | 2.66272398 |
| 31 | Abnormality of T cell number (HP:0011839) | 2.59385406 |
| 32 | Increased serum lactate (HP:0002151) | 2.58808871 |
| 33 | Optic disc pallor (HP:0000543) | 2.50325319 |
| 34 | Metaphyseal dysplasia (HP:0100255) | 2.50266960 |
| 35 | T lymphocytopenia (HP:0005403) | 2.49291221 |
| 36 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.46986105 |
| 37 | Abolished electroretinogram (ERG) (HP:0000550) | 2.44835601 |
| 38 | Hypoplasia of the pons (HP:0012110) | 2.41739917 |
| 39 | Pancreatic cysts (HP:0001737) | 2.38680222 |
| 40 | Parakeratosis (HP:0001036) | 2.38514467 |
| 41 | Aplastic anemia (HP:0001915) | 2.38081741 |
| 42 | Abnormality of the pons (HP:0007361) | 2.31824596 |
| 43 | Lactic acidosis (HP:0003128) | 2.31479017 |
| 44 | Severe combined immunodeficiency (HP:0004430) | 2.31237823 |
| 45 | Methylmalonic aciduria (HP:0012120) | 2.31027487 |
| 46 | Methylmalonic acidemia (HP:0002912) | 2.27157538 |
| 47 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.24790740 |
| 48 | Hypoproteinemia (HP:0003075) | 2.23596819 |
| 49 | Thyroiditis (HP:0100646) | 2.18203876 |
| 50 | Myositis (HP:0100614) | 2.14463365 |
| 51 | Progressive microcephaly (HP:0000253) | 2.14261217 |
| 52 | Congenital, generalized hypertrichosis (HP:0004540) | 2.12614646 |
| 53 | Respiratory failure (HP:0002878) | 2.10438821 |
| 54 | Renal Fanconi syndrome (HP:0001994) | 2.09039340 |
| 55 | Lethargy (HP:0001254) | 2.08565285 |
| 56 | Abnormality of the renal medulla (HP:0100957) | 2.08081729 |
| 57 | Leukodystrophy (HP:0002415) | 2.05833142 |
| 58 | Generalized aminoaciduria (HP:0002909) | 2.03359079 |
| 59 | Abnormality of the fovea (HP:0000493) | 2.02907349 |
| 60 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.00361736 |
| 61 | Hypoplasia of the fovea (HP:0007750) | 2.00050592 |
| 62 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 2.00050592 |
| 63 | Abnormality of the prostate (HP:0008775) | 1.96989446 |
| 64 | Abnormality of eosinophils (HP:0001879) | 1.94526590 |
| 65 | Erythroderma (HP:0001019) | 1.93904872 |
| 66 | CNS demyelination (HP:0007305) | 1.92121833 |
| 67 | Chronic hepatic failure (HP:0100626) | 1.91136341 |
| 68 | Autoimmune thrombocytopenia (HP:0001973) | 1.88242196 |
| 69 | Exertional dyspnea (HP:0002875) | 1.86781479 |
| 70 | Median cleft lip (HP:0000161) | 1.85943181 |
| 71 | Cerebellar dysplasia (HP:0007033) | 1.85611703 |
| 72 | Cleft eyelid (HP:0000625) | 1.85556886 |
| 73 | Pendular nystagmus (HP:0012043) | 1.84298534 |
| 74 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.83988752 |
| 75 | Retrobulbar optic neuritis (HP:0100654) | 1.83975114 |
| 76 | Optic neuritis (HP:0100653) | 1.83975114 |
| 77 | Recurrent cutaneous fungal infections (HP:0011370) | 1.83010269 |
| 78 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.83010269 |
| 79 | Dicarboxylic aciduria (HP:0003215) | 1.82049539 |
| 80 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.82049539 |
| 81 | Abnormality of B cell number (HP:0010975) | 1.81616541 |
| 82 | Abnormality of the nasal septum (HP:0000419) | 1.81575813 |
| 83 | Exercise intolerance (HP:0003546) | 1.78632191 |
| 84 | Neutropenia (HP:0001875) | 1.78332705 |
| 85 | Carpal bone hypoplasia (HP:0001498) | 1.77879188 |
| 86 | Hypergammaglobulinemia (HP:0010702) | 1.74228053 |
| 87 | Adactyly (HP:0009776) | 1.73811335 |
| 88 | Panhypogammaglobulinemia (HP:0003139) | 1.73515961 |
| 89 | Opisthotonus (HP:0002179) | 1.71259766 |
| 90 | Pancytopenia (HP:0001876) | 1.71007706 |
| 91 | True hermaphroditism (HP:0010459) | 1.70152494 |
| 92 | Increased intramyocellular lipid droplets (HP:0012240) | 1.69672919 |
| 93 | Increased serum pyruvate (HP:0003542) | 1.67170073 |
| 94 | Increased corneal curvature (HP:0100692) | 1.66481212 |
| 95 | Keratoconus (HP:0000563) | 1.66481212 |
| 96 | Chronic sinusitis (HP:0011109) | 1.66352799 |
| 97 | Muscle fiber atrophy (HP:0100295) | 1.65242117 |
| 98 | Reduced antithrombin III activity (HP:0001976) | 1.64248157 |
| 99 | Attenuation of retinal blood vessels (HP:0007843) | 1.63421740 |
| 100 | Respiratory difficulties (HP:0002880) | 1.62604661 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NME1 | 3.63648736 |
| 2 | MST4 | 3.32115683 |
| 3 | ZAK | 3.25412718 |
| 4 | ADRBK2 | 3.12412652 |
| 5 | BCKDK | 2.97075064 |
| 6 | TXK | 2.75904391 |
| 7 | VRK2 | 2.61001102 |
| 8 | MAP4K2 | 2.45024339 |
| 9 | TSSK6 | 2.38078364 |
| 10 | EIF2AK3 | 2.35481285 |
| 11 | TIE1 | 2.33375687 |
| 12 | NUAK1 | 2.29990820 |
| 13 | TLK1 | 2.19493928 |
| 14 | BMPR1B | 2.15524874 |
| 15 | GRK1 | 1.96825325 |
| 16 | NEK1 | 1.85904888 |
| 17 | TAF1 | 1.80632159 |
| 18 | INSRR | 1.79866707 |
| 19 | DAPK2 | 1.79455939 |
| 20 | DAPK1 | 1.71818157 |
| 21 | VRK1 | 1.65887875 |
| 22 | DYRK2 | 1.60503187 |
| 23 | WNK4 | 1.57960143 |
| 24 | TRIM28 | 1.54686957 |
| 25 | FRK | 1.53421845 |
| 26 | MAPKAPK3 | 1.51512830 |
| 27 | ACVR1B | 1.44066552 |
| 28 | PHKG2 | 1.39722495 |
| 29 | PHKG1 | 1.39722495 |
| 30 | TAOK3 | 1.37962534 |
| 31 | CSNK1A1L | 1.34681079 |
| 32 | CSNK1G3 | 1.21768638 |
| 33 | PLK3 | 1.15201554 |
| 34 | MAP4K1 | 1.14560009 |
| 35 | PINK1 | 1.13202390 |
| 36 | SRPK1 | 1.12685870 |
| 37 | CSNK1G2 | 1.12072107 |
| 38 | OXSR1 | 1.08303477 |
| 39 | PLK2 | 1.06405912 |
| 40 | EIF2AK2 | 1.06244937 |
| 41 | TEC | 1.03412074 |
| 42 | IKBKB | 0.97498220 |
| 43 | MAP2K6 | 0.96976184 |
| 44 | KIT | 0.92329059 |
| 45 | FLT3 | 0.89660557 |
| 46 | CSNK1G1 | 0.88214885 |
| 47 | PAK3 | 0.83737550 |
| 48 | LCK | 0.80919210 |
| 49 | PAK6 | 0.80337251 |
| 50 | ITK | 0.75646588 |
| 51 | WNK3 | 0.74882161 |
| 52 | SYK | 0.74700463 |
| 53 | MKNK1 | 0.73948417 |
| 54 | GRK5 | 0.71635121 |
| 55 | KDR | 0.68094205 |
| 56 | IKBKE | 0.67480279 |
| 57 | PRKCQ | 0.65943642 |
| 58 | BCR | 0.63462253 |
| 59 | EPHA3 | 0.62930992 |
| 60 | CASK | 0.62917754 |
| 61 | EIF2AK1 | 0.62178592 |
| 62 | RPS6KA5 | 0.59669865 |
| 63 | CSF1R | 0.58860759 |
| 64 | MAPKAPK5 | 0.58331971 |
| 65 | GRK7 | 0.58013557 |
| 66 | LYN | 0.57438099 |
| 67 | CDK19 | 0.56574355 |
| 68 | MAP3K12 | 0.56402946 |
| 69 | TBK1 | 0.55957175 |
| 70 | TGFBR1 | 0.55150390 |
| 71 | FES | 0.53873159 |
| 72 | STK39 | 0.52607797 |
| 73 | BTK | 0.51358604 |
| 74 | MATK | 0.48049201 |
| 75 | DAPK3 | 0.47951979 |
| 76 | PLK4 | 0.46977691 |
| 77 | ADRBK1 | 0.46748725 |
| 78 | CHUK | 0.46197541 |
| 79 | MKNK2 | 0.44948755 |
| 80 | SIK3 | 0.44041585 |
| 81 | MAP2K2 | 0.43730805 |
| 82 | IGF1R | 0.40963681 |
| 83 | STK16 | 0.40878396 |
| 84 | PDK2 | 0.39754378 |
| 85 | RPS6KA4 | 0.38582014 |
| 86 | ERBB3 | 0.36842935 |
| 87 | PRKCG | 0.36443804 |
| 88 | PRKCH | 0.36382542 |
| 89 | ALK | 0.36097903 |
| 90 | GRK6 | 0.35317027 |
| 91 | ATR | 0.35163864 |
| 92 | STK4 | 0.34337769 |
| 93 | CSNK1D | 0.31558083 |
| 94 | CSNK2A2 | 0.31238578 |
| 95 | JAK3 | 0.30985990 |
| 96 | CSNK1A1 | 0.30614224 |
| 97 | OBSCN | 0.30128167 |
| 98 | MAP3K4 | 0.29717696 |
| 99 | CSNK2A1 | 0.29691132 |
| 100 | EGFR | 0.29682715 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.77558877 |
| 2 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.23434652 |
| 3 | Protein export_Homo sapiens_hsa03060 | 2.93442596 |
| 4 | Asthma_Homo sapiens_hsa05310 | 2.85253387 |
| 5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.78536414 |
| 6 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.66064260 |
| 7 | Allograft rejection_Homo sapiens_hsa05330 | 2.61455350 |
| 8 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.56042763 |
| 9 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.42379636 |
| 10 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.38152754 |
| 11 | Parkinsons disease_Homo sapiens_hsa05012 | 2.37992099 |
| 12 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.35356453 |
| 13 | Ribosome_Homo sapiens_hsa03010 | 2.25964461 |
| 14 | RNA polymerase_Homo sapiens_hsa03020 | 2.25250382 |
| 15 | Basal transcription factors_Homo sapiens_hsa03022 | 2.23917401 |
| 16 | RNA degradation_Homo sapiens_hsa03018 | 1.90915556 |
| 17 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.83116063 |
| 18 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.75467571 |
| 19 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.64854776 |
| 20 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.63786312 |
| 21 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.63702849 |
| 22 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.59940463 |
| 23 | Homologous recombination_Homo sapiens_hsa03440 | 1.58417655 |
| 24 | Alzheimers disease_Homo sapiens_hsa05010 | 1.54236622 |
| 25 | Huntingtons disease_Homo sapiens_hsa05016 | 1.53784634 |
| 26 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.37536710 |
| 27 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.35453198 |
| 28 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.35318288 |
| 29 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.34395841 |
| 30 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.33259762 |
| 31 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.22876642 |
| 32 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.22485269 |
| 33 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.21753164 |
| 34 | Base excision repair_Homo sapiens_hsa03410 | 1.20809679 |
| 35 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.18895626 |
| 36 | Peroxisome_Homo sapiens_hsa04146 | 1.17209301 |
| 37 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.16767761 |
| 38 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.14307833 |
| 39 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.08146544 |
| 40 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.07717879 |
| 41 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.99523409 |
| 42 | RNA transport_Homo sapiens_hsa03013 | 0.98729011 |
| 43 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.98435826 |
| 44 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.97691874 |
| 45 | Mismatch repair_Homo sapiens_hsa03430 | 0.95211074 |
| 46 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.94593674 |
| 47 | Purine metabolism_Homo sapiens_hsa00230 | 0.93612894 |
| 48 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.92089038 |
| 49 | Phototransduction_Homo sapiens_hsa04744 | 0.88061318 |
| 50 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.87027221 |
| 51 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.86190606 |
| 52 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.85784037 |
| 53 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.85769582 |
| 54 | Spliceosome_Homo sapiens_hsa03040 | 0.85446972 |
| 55 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.78440806 |
| 56 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.77434869 |
| 57 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.76948546 |
| 58 | Measles_Homo sapiens_hsa05162 | 0.73289108 |
| 59 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.72303083 |
| 60 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.71846358 |
| 61 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.70341718 |
| 62 | Retinol metabolism_Homo sapiens_hsa00830 | 0.67481255 |
| 63 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.67034536 |
| 64 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.66968476 |
| 65 | Sulfur relay system_Homo sapiens_hsa04122 | 0.65081293 |
| 66 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.64405074 |
| 67 | Taste transduction_Homo sapiens_hsa04742 | 0.63866484 |
| 68 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.63510209 |
| 69 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.59583960 |
| 70 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.56713638 |
| 71 | Viral myocarditis_Homo sapiens_hsa05416 | 0.55289887 |
| 72 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.54843535 |
| 73 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.54362322 |
| 74 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.53810092 |
| 75 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.53337356 |
| 76 | Metabolic pathways_Homo sapiens_hsa01100 | 0.51866261 |
| 77 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.50716732 |
| 78 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.49751780 |
| 79 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.48262855 |
| 80 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.46719609 |
| 81 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.46358742 |
| 82 | Apoptosis_Homo sapiens_hsa04210 | 0.43644597 |
| 83 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.41549615 |
| 84 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.40602193 |
| 85 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.39824033 |
| 86 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.38016943 |
| 87 | DNA replication_Homo sapiens_hsa03030 | 0.37997266 |
| 88 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.35108434 |
| 89 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.34817972 |
| 90 | Olfactory transduction_Homo sapiens_hsa04740 | 0.33292663 |
| 91 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.32689196 |
| 92 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.31515094 |
| 93 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.30970978 |
| 94 | Circadian rhythm_Homo sapiens_hsa04710 | 0.27087276 |
| 95 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.26090019 |
| 96 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.25832608 |
| 97 | Legionellosis_Homo sapiens_hsa05134 | 0.25150180 |
| 98 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.25118358 |
| 99 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.24741089 |
| 100 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.24047022 |

