PSMB5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.09230482
2ribosomal small subunit assembly (GO:0000028)5.66460373
3viral transcription (GO:0019083)5.22377547
4translational termination (GO:0006415)5.07589773
5proteasome assembly (GO:0043248)4.88385533
6maturation of SSU-rRNA (GO:0030490)4.71124859
7translational elongation (GO:0006414)4.68682124
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.64909825
9ribosomal small subunit biogenesis (GO:0042274)4.61763706
10formation of translation preinitiation complex (GO:0001731)4.60085355
11cotranslational protein targeting to membrane (GO:0006613)4.52345722
12protein targeting to ER (GO:0045047)4.51017723
13deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.46383259
14ribosomal large subunit biogenesis (GO:0042273)4.39473349
15translational initiation (GO:0006413)4.36165523
16protein localization to endoplasmic reticulum (GO:0070972)4.34190109
17DNA strand elongation involved in DNA replication (GO:0006271)4.31534856
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.25905794
19* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.24776730
20telomere maintenance via semi-conservative replication (GO:0032201)4.20887724
21DNA strand elongation (GO:0022616)4.09959495
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.07914830
23viral life cycle (GO:0019058)4.07437977
24nucleobase biosynthetic process (GO:0046112)4.02331657
25ribonucleoprotein complex biogenesis (GO:0022613)4.00305715
26cellular protein complex disassembly (GO:0043624)3.98807182
27translation (GO:0006412)3.97732858
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.97334300
29* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.94532614
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.93219894
31* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.92121343
32purine nucleobase biosynthetic process (GO:0009113)3.88024277
33respiratory chain complex IV assembly (GO:0008535)3.85670019
34chromatin remodeling at centromere (GO:0031055)3.85243293
35* negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.84448061
36* negative regulation of ligase activity (GO:0051352)3.84448061
37* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.83674177
38* regulation of cellular amino acid metabolic process (GO:0006521)3.83396513
39CENP-A containing nucleosome assembly (GO:0034080)3.78703944
40DNA replication initiation (GO:0006270)3.78121651
41* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.76270520
42* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.73439277
43energy coupled proton transport, down electrochemical gradient (GO:0015985)3.73401162
44ATP synthesis coupled proton transport (GO:0015986)3.73401162
45pseudouridine synthesis (GO:0001522)3.71592429
46spliceosomal snRNP assembly (GO:0000387)3.71239995
47ribosome biogenesis (GO:0042254)3.71093730
48* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.66563351
49* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.66563351
50* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.63177890
51* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.63177890
52* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.63177890
53respiratory electron transport chain (GO:0022904)3.61959791
54termination of RNA polymerase III transcription (GO:0006386)3.61627123
55transcription elongation from RNA polymerase III promoter (GO:0006385)3.61627123
56protein complex biogenesis (GO:0070271)3.61050265
57protein neddylation (GO:0045116)3.60537471
58telomere maintenance via recombination (GO:0000722)3.60257645
59* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.56025324
60* signal transduction involved in DNA integrity checkpoint (GO:0072401)3.54314906
61* signal transduction involved in DNA damage checkpoint (GO:0072422)3.54314906
62electron transport chain (GO:0022900)3.53574575
63L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.52830363
64mitochondrial respiratory chain complex assembly (GO:0033108)3.50952580
65cellular component biogenesis (GO:0044085)3.50167367
66* signal transduction involved in cell cycle checkpoint (GO:0072395)3.50012725
67protein complex disassembly (GO:0043241)3.49990470
68oxidative phosphorylation (GO:0006119)3.48876729
69cullin deneddylation (GO:0010388)3.48522312
70* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.45565363
71rRNA processing (GO:0006364)3.45130420
72nucleobase-containing small molecule interconversion (GO:0015949)3.45038969
73cytochrome complex assembly (GO:0017004)3.41225723
74establishment of viral latency (GO:0019043)3.40890279
75protein deneddylation (GO:0000338)3.40336211
76DNA double-strand break processing (GO:0000729)3.40098909
77regulation of mitochondrial translation (GO:0070129)3.38857520
78macromolecular complex disassembly (GO:0032984)3.36269300
79* positive regulation of ligase activity (GO:0051351)3.33723346
80ribosome assembly (GO:0042255)3.32405079
81rRNA metabolic process (GO:0016072)3.29488263
82DNA replication checkpoint (GO:0000076)3.29041839
83chaperone-mediated protein transport (GO:0072321)3.28453767
84histone exchange (GO:0043486)3.25303790
85protein targeting to mitochondrion (GO:0006626)3.24752046
86establishment of protein localization to mitochondrion (GO:0072655)3.23226558
87IMP biosynthetic process (GO:0006188)3.22443368
88mitotic metaphase plate congression (GO:0007080)3.22391550
89mitotic recombination (GO:0006312)3.20865445
90NADH dehydrogenase complex assembly (GO:0010257)3.20025398
91mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.20025398
92mitochondrial respiratory chain complex I assembly (GO:0032981)3.20025398
93DNA unwinding involved in DNA replication (GO:0006268)3.17732718
94rRNA modification (GO:0000154)3.17042168
95DNA damage response, detection of DNA damage (GO:0042769)3.16065245
96folic acid metabolic process (GO:0046655)3.15415074
97nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15312264
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14787949
99establishment of integrated proviral latency (GO:0075713)3.13950844
100telomere maintenance via telomere lengthening (GO:0010833)3.13592731
101pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.13066914
1022-deoxyribonucleotide biosynthetic process (GO:0009265)3.12886579
103deoxyribose phosphate biosynthetic process (GO:0046385)3.12886579
1047-methylguanosine mRNA capping (GO:0006370)3.11321641
105* G1/S transition of mitotic cell cycle (GO:0000082)3.11284873
106* cell cycle G1/S phase transition (GO:0044843)3.11284873
107folic acid-containing compound biosynthetic process (GO:0009396)3.10321915
108transcription-coupled nucleotide-excision repair (GO:0006283)3.08594868
109* regulation of ubiquitin-protein transferase activity (GO:0051438)3.06147254
110nuclear-transcribed mRNA catabolic process (GO:0000956)3.05745291
111* regulation of cellular amine metabolic process (GO:0033238)3.04846593
112lactate metabolic process (GO:0006089)3.04005525
113RNA capping (GO:0036260)3.03090881
1147-methylguanosine RNA capping (GO:0009452)3.03090881
115water-soluble vitamin biosynthetic process (GO:0042364)3.01715756
116* positive regulation of cell cycle arrest (GO:0071158)2.99184068
117protein targeting to membrane (GO:0006612)2.98281638
118tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.98167449
119RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.98167449
120* regulation of ligase activity (GO:0051340)2.97986788
121deoxyribonucleotide biosynthetic process (GO:0009263)2.97324099
122establishment of protein localization to mitochondrial membrane (GO:0090151)2.96788827
123DNA replication-independent nucleosome organization (GO:0034724)2.96229500
124DNA replication-independent nucleosome assembly (GO:0006336)2.96229500
125metaphase plate congression (GO:0051310)2.95820189
126DNA catabolic process, exonucleolytic (GO:0000738)2.95603164
127nucleotide-excision repair, DNA gap filling (GO:0006297)2.95253933
128inner mitochondrial membrane organization (GO:0007007)2.95151780
129protein localization to mitochondrion (GO:0070585)2.95109282
130peptidyl-histidine modification (GO:0018202)2.94837834
131L-methionine biosynthetic process (GO:0071265)2.94797435
132amino acid salvage (GO:0043102)2.94797435
133regulation of mitotic spindle checkpoint (GO:1903504)2.94701224
134regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.94701224
135* negative regulation of protein ubiquitination (GO:0031397)2.94459149
136L-serine metabolic process (GO:0006563)2.92869984
137DNA ligation (GO:0006266)2.91519787
138pteridine-containing compound biosynthetic process (GO:0042559)2.84259167
139rRNA methylation (GO:0031167)2.83200370
140* DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.82397781
141spindle checkpoint (GO:0031577)2.81099477
142protein localization to kinetochore (GO:0034501)2.78229274
143* negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.73753979
144DNA replication-dependent nucleosome assembly (GO:0006335)2.70965332
145DNA replication-dependent nucleosome organization (GO:0034723)2.70965332
146mitotic spindle checkpoint (GO:0071174)2.70573814
147double-strand break repair via nonhomologous end joining (GO:0006303)2.70300925
148non-recombinational repair (GO:0000726)2.70300925
149IMP metabolic process (GO:0046040)2.70264937
150aldehyde catabolic process (GO:0046185)2.70057326
151replication fork processing (GO:0031297)2.68394085

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.47478403
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.40705566
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.31473827
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.68589198
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.54260575
6* GABP_17652178_ChIP-ChIP_JURKAT_Human3.49102740
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.31041849
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.27015710
9MYC_18358816_ChIP-ChIP_MESCs_Mouse3.16029500
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.13154760
11* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.97654054
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86494771
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81208039
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80501628
15XRN2_22483619_ChIP-Seq_HELA_Human2.46169020
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.44246150
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.38719335
18* VDR_23849224_ChIP-Seq_CD4+_Human2.34761178
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31281922
20* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.31246572
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.30664897
22DCP1A_22483619_ChIP-Seq_HELA_Human2.25239614
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20769653
24* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19029421
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.12210992
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.10659752
27GABP_19822575_ChIP-Seq_HepG2_Human2.10117822
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.09056847
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01508320
30FOXP3_21729870_ChIP-Seq_TREG_Human2.01296650
31* SRF_21415370_ChIP-Seq_HL-1_Mouse1.95533262
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.86821379
33TTF2_22483619_ChIP-Seq_HELA_Human1.86723389
34* YY1_21170310_ChIP-Seq_MESCs_Mouse1.86682777
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83073835
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81041976
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.73187006
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66251731
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65642116
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65477651
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.64303349
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61616854
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59054850
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58648057
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57581564
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57180380
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53213771
48* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52811195
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50104956
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49807335
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49485678
52ELK1_19687146_ChIP-ChIP_HELA_Human1.49274240
53* NANOG_16153702_ChIP-ChIP_HESCs_Human1.46318837
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43934037
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43562260
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41052146
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.40855725
58ZNF274_21170338_ChIP-Seq_K562_Hela1.39827346
59* CIITA_25753668_ChIP-Seq_RAJI_Human1.39312588
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38716584
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38159401
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.34564176
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32889556
64AR_21909140_ChIP-Seq_LNCAP_Human1.30058525
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29760122
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28047776
67* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27275138
68KDM5A_27292631_Chip-Seq_BREAST_Human1.25707661
69EWS_26573619_Chip-Seq_HEK293_Human1.25550422
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.23672299
71FUS_26573619_Chip-Seq_HEK293_Human1.22739550
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22227104
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21981538
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.21691389
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.21571335
76MYC_22102868_ChIP-Seq_BL_Human1.21532583
77TFEB_21752829_ChIP-Seq_HELA_Human1.20240288
78VDR_22108803_ChIP-Seq_LS180_Human1.18558137
79PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14454640
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.13442211
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13367061
82* SOX17_20123909_ChIP-Seq_XEN_Mouse1.12172739
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11117731
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10778128
85VDR_21846776_ChIP-Seq_THP-1_Human1.09244088
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08980097
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08141868
88* SPI1_23547873_ChIP-Seq_NB4_Human1.07751681
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.07473922
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06277242
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05047879
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04956085
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04806568
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04791118
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04701849
96* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.04065185
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03026069
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02083723
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02079116
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01922802
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01642721
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01501818
103CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01410738
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97015842
105PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96626926
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96077051
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95436310
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93959519
109IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93639578
110NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92873228
111MYC_18940864_ChIP-ChIP_HL60_Human0.92785549
112OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92484403
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91993058
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91343410
115EOMES_21245162_ChIP-Seq_HESCs_Human0.89772849
116P300_19829295_ChIP-Seq_ESCs_Human0.89743817
117EGR1_19374776_ChIP-ChIP_THP-1_Human0.87650037
118ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87333487
119EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87140506
120* YY1_22570637_ChIP-Seq_MALME-3M_Human0.86035595
121POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85229952
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83830157
123SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83675892
124* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83389503
125RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81561025
126* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.81549709
127FOXP1_21924763_ChIP-Seq_HESCs_Human0.81163087
128GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.80482521
129ZFP57_27257070_Chip-Seq_ESCs_Mouse0.75780821
130TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75514304
131CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.75272087
132HTT_18923047_ChIP-ChIP_STHdh_Human0.73316469
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.70039508
134NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.69179299
135IGF1R_20145208_ChIP-Seq_DFB_Human0.65429118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.81328473
2MP0004957_abnormal_blastocyst_morpholog4.29605291
3MP0003806_abnormal_nucleotide_metabolis3.41883578
4MP0003111_abnormal_nucleus_morphology3.39783375
5MP0010094_abnormal_chromosome_stability3.37936409
6MP0003077_abnormal_cell_cycle3.37840952
7MP0008058_abnormal_DNA_repair3.05655753
8MP0003186_abnormal_redox_activity2.92595913
9MP0002938_white_spotting2.58532948
10MP0003941_abnormal_skin_development2.56214340
11MP0008932_abnormal_embryonic_tissue2.55677624
12MP0008007_abnormal_cellular_replicative2.41994276
13MP0006036_abnormal_mitochondrial_physio2.41247287
14MP0009379_abnormal_foot_pigmentation2.25717087
15MP0008057_abnormal_DNA_replication2.24372182
16MP0002396_abnormal_hematopoietic_system2.12122413
17MP0009333_abnormal_splenocyte_physiolog2.10232255
18MP0001529_abnormal_vocalization2.07686966
19MP0003195_calcinosis2.04523330
20MP0003136_yellow_coat_color2.00706942
21MP0001853_heart_inflammation1.99839126
22MP0002102_abnormal_ear_morphology1.98116957
23MP0000490_abnormal_crypts_of1.90404421
24MP0006035_abnormal_mitochondrial_morpho1.88935638
25MP0001730_embryonic_growth_arrest1.88568791
26MP0009785_altered_susceptibility_to1.81618842
27MP0009697_abnormal_copulation1.78079758
28MP0005397_hematopoietic_system_phenotyp1.73867070
29MP0001545_abnormal_hematopoietic_system1.73867070
30MP0003786_premature_aging1.72312983
31MP0003122_maternal_imprinting1.69334944
32MP0008789_abnormal_olfactory_epithelium1.68934528
33MP0003890_abnormal_embryonic-extraembry1.67989600
34MP0000358_abnormal_cell_content/1.66895371
35MP0000350_abnormal_cell_proliferation1.66343228
36MP0006072_abnormal_retinal_apoptosis1.65921329
37MP0003436_decreased_susceptibility_to1.65849299
38MP0003718_maternal_effect1.61969370
39MP0001293_anophthalmia1.61294500
40MP0002736_abnormal_nociception_after1.57486908
41MP0001835_abnormal_antigen_presentation1.54291444
42MP0003121_genomic_imprinting1.54144254
43MP0003123_paternal_imprinting1.53310363
44MP0000313_abnormal_cell_death1.49559082
45MP0000858_altered_metastatic_potential1.49479369
46MP0002019_abnormal_tumor_incidence1.48585642
47MP0005408_hypopigmentation1.44677979
48MP0003646_muscle_fatigue1.43495626
49MP0002132_abnormal_respiratory_system1.41365052
50MP0003011_delayed_dark_adaptation1.38188798
51MP0005075_abnormal_melanosome_morpholog1.37298299
52MP0009840_abnormal_foam_cell1.36657520
53MP0003656_abnormal_erythrocyte_physiolo1.35672194
54MP0002837_dystrophic_cardiac_calcinosis1.35047959
55MP0003763_abnormal_thymus_physiology1.32474188
56MP0005499_abnormal_olfactory_system1.31729636
57MP0005394_taste/olfaction_phenotype1.31729636
58MP0002398_abnormal_bone_marrow1.31010706
59MP0001764_abnormal_homeostasis1.30981978
60MP0005025_abnormal_response_to1.30669086
61MP0002722_abnormal_immune_system1.29117738
62MP0006054_spinal_hemorrhage1.28648849
63MP0000689_abnormal_spleen_morphology1.28223078
64MP0003937_abnormal_limbs/digits/tail_de1.26823508
65MP0002080_prenatal_lethality1.26780901
66MP0002148_abnormal_hypersensitivity_rea1.25924535
67MP0004147_increased_porphyrin_level1.25789913
68MP0003119_abnormal_digestive_system1.25085284
69MP0006292_abnormal_olfactory_placode1.20633494
70MP0001697_abnormal_embryo_size1.19932700
71MP0004808_abnormal_hematopoietic_stem1.19450702
72MP0002429_abnormal_blood_cell1.19179568
73MP0005671_abnormal_response_to1.18725502
74MP0010352_gastrointestinal_tract_polyps1.18052323
75MP0001984_abnormal_olfaction1.17757592
76MP0002233_abnormal_nose_morphology1.17307380
77MP0000750_abnormal_muscle_regeneration1.16843842
78MP0002254_reproductive_system_inflammat1.14819026
79MP0002090_abnormal_vision1.14599773
80MP0002751_abnormal_autonomic_nervous1.12618588
81MP0000516_abnormal_urinary_system1.09681855
82MP0005367_renal/urinary_system_phenotyp1.09681855
83MP0005253_abnormal_eye_physiology1.05067948
84MP0000647_abnormal_sebaceous_gland1.04765413
85MP0000716_abnormal_immune_system1.03598310
86MP0003221_abnormal_cardiomyocyte_apopto1.02767772
87MP0003283_abnormal_digestive_organ1.00972094
88MP0008995_early_reproductive_senescence1.00928855
89MP0005000_abnormal_immune_tolerance1.00614599
90MP0002163_abnormal_gland_morphology0.99938749
91MP0003567_abnormal_fetal_cardiomyocyte0.99367132
92MP0002420_abnormal_adaptive_immunity0.98100674
93MP0009672_abnormal_birth_weight0.97981554
94MP0003315_abnormal_perineum_morphology0.97731626
95MP0001819_abnormal_immune_cell0.97712370
96MP0000703_abnormal_thymus_morphology0.96738632
97MP0002723_abnormal_immune_serum0.95798916
98MP0001286_abnormal_eye_development0.95223626
99MP0003880_abnormal_central_pattern0.94662994
100MP0002084_abnormal_developmental_patter0.94654762
101MP0008469_abnormal_protein_level0.93964746
102MP0001672_abnormal_embryogenesis/_devel0.93147121
103MP0005380_embryogenesis_phenotype0.93147121
104MP0005266_abnormal_metabolism0.92817497
105MP0000685_abnormal_immune_system0.92698641
106MP0002405_respiratory_system_inflammati0.92479890
107MP0002452_abnormal_antigen_presenting0.92326581
108MP0005379_endocrine/exocrine_gland_phen0.91966137
109MP0008260_abnormal_autophagy0.91163624
110MP0002697_abnormal_eye_size0.89652923
111MP0005319_abnormal_enzyme/_coenzyme0.89645131
112MP0002210_abnormal_sex_determination0.88694130
113MP0005551_abnormal_eye_electrophysiolog0.87131826
114MP0002160_abnormal_reproductive_system0.86864607
115MP0000343_altered_response_to0.86670349
116MP0003984_embryonic_growth_retardation0.86644769
117MP0000749_muscle_degeneration0.86582916
118MP0005395_other_phenotype0.85595655
119MP0010307_abnormal_tumor_latency0.83864134
120MP0003755_abnormal_palate_morphology0.83833849
121MP0003787_abnormal_imprinting0.83634542
122MP0005636_abnormal_mineral_homeostasis0.83452702
123MP0001929_abnormal_gametogenesis0.83293139
124MP0002111_abnormal_tail_morphology0.83096965
125MP0002088_abnormal_embryonic_growth/wei0.82919607
126MP0004133_heterotaxia0.82492164
127MP0004215_abnormal_myocardial_fiber0.81690493
128MP0002419_abnormal_innate_immunity0.81307652
129MP0001800_abnormal_humoral_immune0.81160410
130MP0008875_abnormal_xenobiotic_pharmacok0.80402820
131MP0001845_abnormal_inflammatory_respons0.80175256
132MP0000049_abnormal_middle_ear0.79951511
133MP0000653_abnormal_sex_gland0.79817435
134MP0009780_abnormal_chondrocyte_physiolo0.79456118
135MP0010030_abnormal_orbit_morphology0.78466424
136MP0003724_increased_susceptibility_to0.76996776
137MP0001299_abnormal_eye_distance/0.76843138
138MP0002234_abnormal_pharynx_morphology0.76630740
139MP0000372_irregular_coat_pigmentation0.74849379
140MP0001485_abnormal_pinna_reflex0.74728052
141MP0001145_abnormal_male_reproductive0.74401106
142MP0005389_reproductive_system_phenotype0.74226566
143MP0002638_abnormal_pupillary_reflex0.74005847
144MP0005464_abnormal_platelet_physiology0.73787588
145MP0001727_abnormal_embryo_implantation0.71494276
146MP0000598_abnormal_liver_morphology0.71484529
147MP0005391_vision/eye_phenotype0.70671758
148MP0001324_abnormal_eye_pigmentation0.69848895
149MP0005332_abnormal_amino_acid0.69799418
150MP0005174_abnormal_tail_pigmentation0.69389132
151MP0005171_absent_coat_pigmentation0.69301097
152MP0005084_abnormal_gallbladder_morpholo0.69107752
153MP0008877_abnormal_DNA_methylation0.68818263
154MP0002282_abnormal_trachea_morphology0.68785397
155MP0000631_abnormal_neuroendocrine_gland0.67549135
156MP0005376_homeostasis/metabolism_phenot0.67132141
157MP0001968_abnormal_touch/_nociception0.67124687
158MP0005330_cardiomyopathy0.67067975
159MP0008873_increased_physiological_sensi0.66022116
160MP0001542_abnormal_bone_strength0.65586097
161MP0005384_cellular_phenotype0.65277834
162MP0002085_abnormal_embryonic_tissue0.65168821
163MP0005023_abnormal_wound_healing0.62806332

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.48913023
2Abnormal number of erythroid precursors (HP:0012131)5.31273423
3Reticulocytopenia (HP:0001896)4.50845290
4Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.48861521
5Decreased activity of mitochondrial respiratory chain (HP:0008972)4.48861521
6Acute necrotizing encephalopathy (HP:0006965)4.34452360
7Hepatocellular necrosis (HP:0001404)4.32592420
8Mitochondrial inheritance (HP:0001427)4.21916926
9Abnormal mitochondria in muscle tissue (HP:0008316)4.16157429
10Hepatic necrosis (HP:0002605)4.15698621
11Increased CSF lactate (HP:0002490)3.98342540
12Acute encephalopathy (HP:0006846)3.69307348
13Aplastic anemia (HP:0001915)3.64427108
14Oral leukoplakia (HP:0002745)3.62726025
15Increased serum lactate (HP:0002151)3.62064629
16Macrocytic anemia (HP:0001972)3.60298854
17Type I transferrin isoform profile (HP:0003642)3.45583590
18Pallor (HP:0000980)3.42148672
19Abnormality of the labia minora (HP:0012880)3.39400880
20Multiple enchondromatosis (HP:0005701)3.33544613
21Birth length less than 3rd percentile (HP:0003561)3.29795403
22Increased hepatocellular lipid droplets (HP:0006565)3.29760262
233-Methylglutaconic aciduria (HP:0003535)3.25043371
24Progressive macrocephaly (HP:0004481)3.24326489
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.24274123
26Lipid accumulation in hepatocytes (HP:0006561)3.11065601
27Lactic acidosis (HP:0003128)3.10375394
28Increased intramyocellular lipid droplets (HP:0012240)3.03034890
29Rough bone trabeculation (HP:0100670)3.00645244
30Exertional dyspnea (HP:0002875)2.93483599
31Microretrognathia (HP:0000308)2.93019478
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.90176888
33Exercise intolerance (HP:0003546)2.90166604
34Reduced antithrombin III activity (HP:0001976)2.85761516
35Cerebral hypomyelination (HP:0006808)2.83943643
36Poor head control (HP:0002421)2.81827045
37Respiratory failure (HP:0002878)2.80268645
38Abnormality of glycolysis (HP:0004366)2.76531970
39Increased serum pyruvate (HP:0003542)2.76531970
40Increased muscle lipid content (HP:0009058)2.74595701
41Degeneration of anterior horn cells (HP:0002398)2.73324316
42Abnormality of the anterior horn cell (HP:0006802)2.73324316
43Cerebral edema (HP:0002181)2.73312302
44Breast hypoplasia (HP:0003187)2.72441213
45Meckel diverticulum (HP:0002245)2.65189671
46Thrombocytosis (HP:0001894)2.61373377
47Abnormality of methionine metabolism (HP:0010901)2.60778852
48Trismus (HP:0000211)2.56105696
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.55992134
50Methylmalonic acidemia (HP:0002912)2.55741007
51Abnormality of the ileum (HP:0001549)2.52938736
52Renal Fanconi syndrome (HP:0001994)2.45069013
53Abnormal protein glycosylation (HP:0012346)2.44329058
54Abnormal glycosylation (HP:0012345)2.44329058
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.44329058
56Abnormal protein N-linked glycosylation (HP:0012347)2.44329058
57CNS demyelination (HP:0007305)2.43093747
58Carpal bone hypoplasia (HP:0001498)2.41309179
59Hypoglycemic coma (HP:0001325)2.40295826
60Hyperglycinemia (HP:0002154)2.40291356
61Elevated erythrocyte sedimentation rate (HP:0003565)2.40026851
62Progressive muscle weakness (HP:0003323)2.39540791
63Hyperinsulinemic hypoglycemia (HP:0000825)2.39466734
64Pancreatic islet-cell hyperplasia (HP:0004510)2.37922351
65Methylmalonic aciduria (HP:0012120)2.37327755
66Leukodystrophy (HP:0002415)2.37161454
67Abnormality of the heme biosynthetic pathway (HP:0010472)2.36414922
68Emotional lability (HP:0000712)2.36004600
69Abnormal lung lobation (HP:0002101)2.35379561
70Nausea (HP:0002018)2.34823957
71Microvesicular hepatic steatosis (HP:0001414)2.33395007
72Respiratory difficulties (HP:0002880)2.30997854
73Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30265870
74Pancytopenia (HP:0001876)2.29535253
75Aplasia/Hypoplasia of the uvula (HP:0010293)2.26481271
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25639865
77Abnormality of alanine metabolism (HP:0010916)2.25639865
78Hyperalaninemia (HP:0003348)2.25639865
79Abnormality of serum amino acid levels (HP:0003112)2.22340698
80Hypoglycemic seizures (HP:0002173)2.21726577
81Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20845519
82Optic disc pallor (HP:0000543)2.19609096
83Abnormality of the preputium (HP:0100587)2.19115047
84Chromsome breakage (HP:0040012)2.16322400
85Premature ovarian failure (HP:0008209)2.14510296
86Agnosia (HP:0010524)2.11609776
87Hypoplastic pelvis (HP:0008839)2.10988084
88Premature graying of hair (HP:0002216)2.10748782
89Megaloblastic anemia (HP:0001889)2.09765783
90Ependymoma (HP:0002888)2.09630542
91Abnormal trabecular bone morphology (HP:0100671)2.08790917
92Petechiae (HP:0000967)2.08242713
93Bifid tongue (HP:0010297)2.07647685
94Muscle fiber atrophy (HP:0100295)2.06908905
95Selective tooth agenesis (HP:0001592)2.06129205
96Patellar aplasia (HP:0006443)2.06070958
97Abnormality of chromosome stability (HP:0003220)2.05478643
98Intestinal atresia (HP:0011100)2.05224295
99Lethargy (HP:0001254)2.02278620
100Colon cancer (HP:0003003)2.01989122
101Secondary amenorrhea (HP:0000869)2.01430720
102Neoplasm of the adrenal gland (HP:0100631)2.00962892
103Abnormality of reticulocytes (HP:0004312)1.98968387
104Death in infancy (HP:0001522)1.97986715
105Aplasia/Hypoplasia of the patella (HP:0006498)1.97740372
106Cleft eyelid (HP:0000625)1.95903268
107Sparse eyelashes (HP:0000653)1.95586307
108Absent thumb (HP:0009777)1.93825947
109Unsteady gait (HP:0002317)1.93512747
110Ragged-red muscle fibers (HP:0003200)1.92949658
111Abnormality of glycine metabolism (HP:0010895)1.90891583
112Abnormality of serine family amino acid metabolism (HP:0010894)1.90891583
113IgM deficiency (HP:0002850)1.90325008
114Poor suck (HP:0002033)1.89720462
115Abnormality of aromatic amino acid family metabolism (HP:0004338)1.89623591
116Dicarboxylic aciduria (HP:0003215)1.89528922
117Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89528922
118Abnormality of pyrimidine metabolism (HP:0004353)1.87639382
119Rhabdomyolysis (HP:0003201)1.86764942
120Cellular immunodeficiency (HP:0005374)1.86464129
121Septo-optic dysplasia (HP:0100842)1.84374647
122Type 2 muscle fiber atrophy (HP:0003554)1.83225994
123Pancreatic cysts (HP:0001737)1.82835599
124Amniotic constriction ring (HP:0009775)1.82790478
125Abnormality of placental membranes (HP:0011409)1.82790478
126Hypothermia (HP:0002045)1.82762390
127X-linked dominant inheritance (HP:0001423)1.82369542
128True hermaphroditism (HP:0010459)1.80467777
129Prominent metopic ridge (HP:0005487)1.80165006
13011 pairs of ribs (HP:0000878)1.77984002
131Abnormality of the duodenum (HP:0002246)1.77421711
132Pancreatic fibrosis (HP:0100732)1.77264457
133Abnormality of urine glucose concentration (HP:0011016)1.76549131
134Glycosuria (HP:0003076)1.76549131
135Bone marrow hypocellularity (HP:0005528)1.75879493
136Esophageal neoplasm (HP:0100751)1.75618801
137Neoplasm of head and neck (HP:0012288)1.75618801
138Hypoplasia of the pons (HP:0012110)1.74700103
139Horseshoe kidney (HP:0000085)1.74552802
140Small intestinal stenosis (HP:0012848)1.74002755
141Duodenal stenosis (HP:0100867)1.74002755
142Neoplasm of the pancreas (HP:0002894)1.73655412
143Hyperglycinuria (HP:0003108)1.71809162
144Abnormality of renal resorption (HP:0011038)1.71158829
145Facial cleft (HP:0002006)1.70814609
146Abnormality of the pancreatic islet cells (HP:0006476)1.70352718
147Abnormality of endocrine pancreas physiology (HP:0012093)1.70352718
148Gliosis (HP:0002171)1.70169237
149Generalized aminoaciduria (HP:0002909)1.69950380
150Medial flaring of the eyebrow (HP:0010747)1.69597833
151Postnatal microcephaly (HP:0005484)1.69416365
152Adrenal hypoplasia (HP:0000835)1.68058952

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.59544766
2NME24.47189958
3WEE14.21667324
4EIF2AK13.98474929
5VRK23.63512135
6STK163.25333337
7EIF2AK32.78860326
8PIM22.74726073
9TRIM282.67498658
10MST42.66089802
11TESK22.49698070
12ACVR1B2.23341157
13VRK12.06297587
14SRPK12.01120700
15MAP3K112.00814453
16BCKDK1.96993517
17TNIK1.93525743
18WNK31.90926592
19NEK11.81946084
20KDR1.81658801
21CDC71.79308438
22RPS6KA41.71910501
23NUAK11.66760977
24NME11.64988008
25BMPR1B1.60503939
26ARAF1.60401092
27TSSK61.59869791
28TESK11.54745467
29DYRK31.48010586
30BRSK21.46041802
31TAF11.45815541
32PDK21.45144260
33BRSK11.30530380
34NEK21.30295720
35MAP4K21.28450004
36PLK41.28217176
37PLK21.26465118
38PLK11.26162858
39TLK11.25347015
40PAK41.23853327
41BRAF1.23107389
42AURKA1.23053782
43PBK1.20309499
44SCYL21.19691828
45CDK71.19089853
46CDK191.18213156
47CCNB11.12666392
48MAPKAPK31.07585596
49ABL21.07511144
50MAP3K121.06748300
51RPS6KB21.05921964
52FLT31.05794295
53MAP4K11.05700819
54AURKB1.05547870
55CSNK1G11.03640640
56TGFBR10.97027842
57TAOK20.95852049
58CSNK1G30.92710479
59MAP3K80.90496195
60DAPK10.90072988
61BCR0.88349914
62FRK0.88007354
63ATR0.86589092
64ZAP700.85360750
65ERBB40.85230792
66GRK10.83395986
67MAP2K30.82824521
68LRRK20.82418334
69ERBB30.82316715
70CSNK1G20.82126962
71TBK10.81297498
72ERN10.81092563
73EPHA20.79409900
74EIF2AK20.79392490
75MKNK10.78800452
76LIMK10.77781031
77BLK0.76318735
78CASK0.76175710
79MYLK0.74939539
80STK38L0.73737266
81CDK40.73358424
82FGFR10.72584380
83MUSK0.71253763
84TTK0.71198800
85PASK0.70618034
86CDK80.70436231
87CSNK2A10.70086679
88PAK10.69183116
89KIT0.68978753
90IRAK30.68698529
91ILK0.68659703
92MAP3K40.65968012
93CSNK2A20.65108734
94BTK0.64871897
95CSNK1A1L0.63551790
96PIM10.63228300
97TYK20.61473481
98TEC0.61106998
99INSRR0.59819978
100FGFR20.58692104
101CHEK20.58445471
102PNCK0.58001535
103PLK30.57391644
104ZAK0.55581499
105MAP2K70.55227045
106PAK30.55122053
107EPHA40.54032986
108ATM0.53597971
109DAPK30.52769728
110RAF10.52069167
111PRKCG0.52044820
112DYRK20.50959263
113ALK0.50801755
114MINK10.48129937
115OXSR10.47688934
116IKBKB0.47462119
117FER0.47297736
118ADRBK20.47216343
119SYK0.45433855
120STK390.44853746
121TIE10.44512758
122MAP2K60.44268206
123CAMKK20.43181372
124MAP3K50.42219039
125PHKG20.41224979
126PHKG10.41224979
127MKNK20.40836443
128CSNK1E0.40301037
129IRAK40.40290881
130STK30.39746939
131NEK90.39440015
132STK40.39356509
133MATK0.38961220
134PINK10.38146933
135PRKCE0.37944565
136RPS6KA50.37595645
137PRKCI0.37066764
138GRK60.35508219
139CHEK10.34709821
140MAP3K30.33011745
141RPS6KC10.32813449
142RPS6KL10.32813449
143LYN0.32758788
144RPS6KA60.32712986
145STK100.29059036
146SIK30.28844226
147CSNK1A10.28531981
148WNK40.27397487
149PRKDC0.26244310
150CDK10.25553266

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.89072573
2* Proteasome_Homo sapiens_hsa030504.72046808
3DNA replication_Homo sapiens_hsa030304.26312351
4RNA polymerase_Homo sapiens_hsa030203.40269837
5Mismatch repair_Homo sapiens_hsa034303.39382231
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.89081703
7Pyrimidine metabolism_Homo sapiens_hsa002402.74922698
8Spliceosome_Homo sapiens_hsa030402.65623980
9Base excision repair_Homo sapiens_hsa034102.58296509
10Oxidative phosphorylation_Homo sapiens_hsa001902.52615870
11Parkinsons disease_Homo sapiens_hsa050122.41220042
12Nucleotide excision repair_Homo sapiens_hsa034202.25891242
13RNA transport_Homo sapiens_hsa030132.19433556
14Homologous recombination_Homo sapiens_hsa034402.18595613
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.98554137
16One carbon pool by folate_Homo sapiens_hsa006701.92402479
17Fatty acid elongation_Homo sapiens_hsa000621.88608748
18Huntingtons disease_Homo sapiens_hsa050161.83088023
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75640495
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74248864
21Protein export_Homo sapiens_hsa030601.73590937
22Folate biosynthesis_Homo sapiens_hsa007901.71896570
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.67496493
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63631050
25Sulfur relay system_Homo sapiens_hsa041221.58100429
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56650732
27Cell cycle_Homo sapiens_hsa041101.49748369
28Steroid biosynthesis_Homo sapiens_hsa001001.48529521
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43758242
30Pentose phosphate pathway_Homo sapiens_hsa000301.37028831
31Alzheimers disease_Homo sapiens_hsa050101.36594106
32Purine metabolism_Homo sapiens_hsa002301.34657745
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29354510
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.25980177
35RNA degradation_Homo sapiens_hsa030181.23015377
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21701541
37Biosynthesis of amino acids_Homo sapiens_hsa012301.14934292
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14922588
39Non-homologous end-joining_Homo sapiens_hsa034501.13315638
40Carbon metabolism_Homo sapiens_hsa012001.11434632
41Fanconi anemia pathway_Homo sapiens_hsa034601.11364321
42Basal transcription factors_Homo sapiens_hsa030221.06826105
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05297948
44p53 signaling pathway_Homo sapiens_hsa041151.03539326
45Butanoate metabolism_Homo sapiens_hsa006501.00690471
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00429483
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.00139655
48Epstein-Barr virus infection_Homo sapiens_hsa051690.99817385
49Glutathione metabolism_Homo sapiens_hsa004800.98928521
50Sulfur metabolism_Homo sapiens_hsa009200.96469769
51Legionellosis_Homo sapiens_hsa051340.90798730
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.86010260
53Fatty acid metabolism_Homo sapiens_hsa012120.82381545
54Fructose and mannose metabolism_Homo sapiens_hsa000510.82124819
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81516635
56Fatty acid degradation_Homo sapiens_hsa000710.75120956
57Galactose metabolism_Homo sapiens_hsa000520.75033800
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75026940
59Selenocompound metabolism_Homo sapiens_hsa004500.72338349
60Tryptophan metabolism_Homo sapiens_hsa003800.70800214
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.69646828
62Herpes simplex infection_Homo sapiens_hsa051680.69524000
63beta-Alanine metabolism_Homo sapiens_hsa004100.67790259
64N-Glycan biosynthesis_Homo sapiens_hsa005100.66975155
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66883055
66Antigen processing and presentation_Homo sapiens_hsa046120.64870078
67Metabolic pathways_Homo sapiens_hsa011000.63341318
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61828404
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60544989
70Collecting duct acid secretion_Homo sapiens_hsa049660.56392788
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56127517
72Systemic lupus erythematosus_Homo sapiens_hsa053220.55159970
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53054434
74Cardiac muscle contraction_Homo sapiens_hsa042600.53026229
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.52996977
76Pyruvate metabolism_Homo sapiens_hsa006200.52732177
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51390574
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49548134
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49242309
80Vitamin digestion and absorption_Homo sapiens_hsa049770.46925015
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46794546
82Regulation of autophagy_Homo sapiens_hsa041400.46395372
83mRNA surveillance pathway_Homo sapiens_hsa030150.45917272
84Thyroid cancer_Homo sapiens_hsa052160.43412320
85Phototransduction_Homo sapiens_hsa047440.41990744
86Chemical carcinogenesis_Homo sapiens_hsa052040.41944258
87Shigellosis_Homo sapiens_hsa051310.41384861
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41276424
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40721463
90Fat digestion and absorption_Homo sapiens_hsa049750.40175166
91Caffeine metabolism_Homo sapiens_hsa002320.39911568
92Tyrosine metabolism_Homo sapiens_hsa003500.38386136
93Retinol metabolism_Homo sapiens_hsa008300.37464541
94Arginine and proline metabolism_Homo sapiens_hsa003300.37359404
95Other glycan degradation_Homo sapiens_hsa005110.37282496
96Basal cell carcinoma_Homo sapiens_hsa052170.34928802
97Viral carcinogenesis_Homo sapiens_hsa052030.34646146
98Renin-angiotensin system_Homo sapiens_hsa046140.33943043
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32686392
100Peroxisome_Homo sapiens_hsa041460.32457891
101Apoptosis_Homo sapiens_hsa042100.31359953
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30570142
103Arginine biosynthesis_Homo sapiens_hsa002200.30520132
104Leishmaniasis_Homo sapiens_hsa051400.29580874
105TGF-beta signaling pathway_Homo sapiens_hsa043500.29297373
106Asthma_Homo sapiens_hsa053100.28948226
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27574908
108Allograft rejection_Homo sapiens_hsa053300.26630392
109Hedgehog signaling pathway_Homo sapiens_hsa043400.26216487
110Vitamin B6 metabolism_Homo sapiens_hsa007500.26020816
111Nitrogen metabolism_Homo sapiens_hsa009100.25490445
112Primary immunodeficiency_Homo sapiens_hsa053400.25068933
113Hippo signaling pathway_Homo sapiens_hsa043900.23729703
114HTLV-I infection_Homo sapiens_hsa051660.23512982
115Measles_Homo sapiens_hsa051620.23498156
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23035987
117Arachidonic acid metabolism_Homo sapiens_hsa005900.20623997
118Oocyte meiosis_Homo sapiens_hsa041140.20595538
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19948856
120Phenylalanine metabolism_Homo sapiens_hsa003600.19917027
121Wnt signaling pathway_Homo sapiens_hsa043100.19182801
122Graft-versus-host disease_Homo sapiens_hsa053320.17781703
123Influenza A_Homo sapiens_hsa051640.15900240
124Pertussis_Homo sapiens_hsa051330.15183228
125Propanoate metabolism_Homo sapiens_hsa006400.14753950
126Vibrio cholerae infection_Homo sapiens_hsa051100.13759638
127HIF-1 signaling pathway_Homo sapiens_hsa040660.13441812
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12242148
129Hematopoietic cell lineage_Homo sapiens_hsa046400.11616315
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11433346
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.11255573
132Hepatitis B_Homo sapiens_hsa051610.11101935
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10740959
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.10543999
135Phagosome_Homo sapiens_hsa041450.09401073

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