PSMB7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)5.09715037
2formation of translation preinitiation complex (GO:0001731)4.68165988
3respiratory electron transport chain (GO:0022904)4.61023433
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.59973660
5electron transport chain (GO:0022900)4.48768855
6ribosomal small subunit assembly (GO:0000028)4.41680457
7regulation of mitochondrial translation (GO:0070129)4.40926821
8purine nucleobase biosynthetic process (GO:0009113)4.39634009
9nucleobase biosynthetic process (GO:0046112)4.39413994
10ribosomal small subunit biogenesis (GO:0042274)4.37482372
11ribosome assembly (GO:0042255)4.34731852
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.15895383
13folic acid-containing compound biosynthetic process (GO:0009396)4.15879243
14cotranslational protein targeting to membrane (GO:0006613)4.11049888
15protein targeting to ER (GO:0045047)4.05929594
16* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.98844784
17establishment of protein localization to endoplasmic reticulum (GO:0072599)3.89070303
18* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.88866566
19* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.87210484
20protein localization to endoplasmic reticulum (GO:0070972)3.86778040
21establishment of viral latency (GO:0019043)3.84049142
22* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.80715006
23protein complex biogenesis (GO:0070271)3.80322833
24protein targeting to mitochondrion (GO:0006626)3.76111201
25mitotic metaphase plate congression (GO:0007080)3.70016978
26mitochondrial respiratory chain complex assembly (GO:0033108)3.69399409
27maturation of SSU-rRNA (GO:0030490)3.69119887
28DNA unwinding involved in DNA replication (GO:0006268)3.67716838
29proteasome assembly (GO:0043248)3.65909200
30protein neddylation (GO:0045116)3.65459979
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.65434772
32NADH dehydrogenase complex assembly (GO:0010257)3.65434772
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.65434772
34IMP biosynthetic process (GO:0006188)3.63783609
35folic acid metabolic process (GO:0046655)3.61711598
36* negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.61087922
37* negative regulation of ligase activity (GO:0051352)3.61087922
38cullin deneddylation (GO:0010388)3.59680747
39DNA replication-dependent nucleosome assembly (GO:0006335)3.58457592
40DNA replication-dependent nucleosome organization (GO:0034723)3.58457592
41ribosome biogenesis (GO:0042254)3.56882507
42glycine metabolic process (GO:0006544)3.56391648
43* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.56197534
44DNA replication initiation (GO:0006270)3.55656705
45DNA strand elongation involved in DNA replication (GO:0006271)3.54561293
46establishment of protein localization to mitochondrion (GO:0072655)3.50879918
47protein localization to mitochondrion (GO:0070585)3.50498749
48* regulation of cellular amino acid metabolic process (GO:0006521)3.48748940
49viral life cycle (GO:0019058)3.48393934
50nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.47527643
51chaperone-mediated protein complex assembly (GO:0051131)3.47315412
52regulation of translational termination (GO:0006449)3.44380752
53cellular component biogenesis (GO:0044085)3.43549779
54cellular protein complex disassembly (GO:0043624)3.41939145
55IMP metabolic process (GO:0046040)3.40177350
56mitotic nuclear envelope disassembly (GO:0007077)3.39624860
57DNA damage response, detection of DNA damage (GO:0042769)3.39591507
58protein deneddylation (GO:0000338)3.35269412
59* positive regulation of ligase activity (GO:0051351)3.35078539
60spliceosomal snRNP assembly (GO:0000387)3.32590852
61serine family amino acid biosynthetic process (GO:0009070)3.31529140
62* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.31118671
63* regulation of cellular amine metabolic process (GO:0033238)3.30270851
64DNA strand elongation (GO:0022616)3.29997404
65inner mitochondrial membrane organization (GO:0007007)3.29280858
66* signal transduction involved in DNA integrity checkpoint (GO:0072401)3.27232634
67* signal transduction involved in DNA damage checkpoint (GO:0072422)3.27232634
68protein localization to kinetochore (GO:0034501)3.26157948
69* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.25862538
70* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.25862538
71establishment of protein localization to mitochondrial membrane (GO:0090151)3.25238996
72* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.22833648
73* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.22833648
74* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.22833648
75* DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.22170567
76mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.21774105
77* signal transduction involved in cell cycle checkpoint (GO:0072395)3.21773430
78* negative regulation of protein ubiquitination (GO:0031397)3.20615452
79L-serine metabolic process (GO:0006563)3.20300511
80ribonucleoprotein complex biogenesis (GO:0022613)3.19586230
81membrane disassembly (GO:0030397)3.19413147
82nuclear envelope disassembly (GO:0051081)3.19413147
83* regulation of ubiquitin-protein transferase activity (GO:0051438)3.17788529
84ribosomal large subunit biogenesis (GO:0042273)3.17350762
85pseudouridine synthesis (GO:0001522)3.14249098
86DNA replication checkpoint (GO:0000076)3.14210136
87protein maturation by protein folding (GO:0022417)3.13306275
88translational initiation (GO:0006413)3.12585146
89ATP biosynthetic process (GO:0006754)3.08772221
90purine nucleoside triphosphate biosynthetic process (GO:0009145)3.07168406
91nucleobase-containing small molecule interconversion (GO:0015949)3.04754866
92purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.03477309
93rRNA metabolic process (GO:0016072)3.02609699
94* negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.02244674
95* regulation of ligase activity (GO:0051340)3.01716667
96oxidative phosphorylation (GO:0006119)3.00703833
97protein complex disassembly (GO:0043241)2.99280273
98deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.98651636
99* cell cycle G1/S phase transition (GO:0044843)2.97693574
100* G1/S transition of mitotic cell cycle (GO:0000082)2.97693574
101* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.96309209
102establishment of integrated proviral latency (GO:0075713)2.95842566
103telomere maintenance via semi-conservative replication (GO:0032201)2.94899380
104translational elongation (GO:0006414)2.93657825
105metaphase plate congression (GO:0051310)2.93028531
106pteridine-containing compound biosynthetic process (GO:0042559)2.91551047
107translational termination (GO:0006415)2.89807755
108rRNA modification (GO:0000154)2.87617862
109* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.87190247
110L-methionine salvage (GO:0071267)2.86971115
111L-methionine biosynthetic process (GO:0071265)2.86971115
112amino acid salvage (GO:0043102)2.86971115
113regulation of spindle organization (GO:0090224)2.86604312
114regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.86281547
115spliceosomal complex assembly (GO:0000245)2.85845138
116viral transcription (GO:0019083)2.85724108
117nuclear pore organization (GO:0006999)2.85275407
118tRNA aminoacylation for protein translation (GO:0006418)2.84301916
119tetrahydrofolate metabolic process (GO:0046653)2.84113415
120L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.83678135
1217-methylguanosine mRNA capping (GO:0006370)2.83136618
122rRNA processing (GO:0006364)2.81462549
123energy coupled proton transport, down electrochemical gradient (GO:0015985)2.81169454
124ATP synthesis coupled proton transport (GO:0015986)2.81169454
125regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80235336
126CENP-A containing nucleosome assembly (GO:0034080)2.79575746
127chromatin remodeling at centromere (GO:0031055)2.78732920
128* positive regulation of cell cycle arrest (GO:0071158)2.78614721
129serine family amino acid metabolic process (GO:0009069)2.78264849
130termination of RNA polymerase III transcription (GO:0006386)2.76698847
131transcription elongation from RNA polymerase III promoter (GO:0006385)2.76698847
132tRNA aminoacylation (GO:0043039)2.75379017
133amino acid activation (GO:0043038)2.75379017
134translation (GO:0006412)2.75333772
135mitotic spindle assembly checkpoint (GO:0007094)2.73312486
136negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.73223317
137negative regulation of sister chromatid segregation (GO:0033046)2.73223317
138negative regulation of mitotic sister chromatid separation (GO:2000816)2.73223317
139negative regulation of mitotic sister chromatid segregation (GO:0033048)2.73223317
140negative regulation of chromosome segregation (GO:0051985)2.72970483
141transcription-coupled nucleotide-excision repair (GO:0006283)2.72376524

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.74554860
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.26341057
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.04545826
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31318938
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.15518203
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.10713147
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.05929193
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.01819636
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.99089499
10* GABP_17652178_ChIP-ChIP_JURKAT_Human2.95995364
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93549474
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86533323
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82130738
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.72598456
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50758952
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48275077
17XRN2_22483619_ChIP-Seq_HELA_Human2.39478741
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37157900
19* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35812531
20* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23246951
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.22349498
22AR_21909140_ChIP-Seq_LNCAP_Human2.19959249
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.12264499
24* VDR_23849224_ChIP-Seq_CD4+_Human2.01887081
25DCP1A_22483619_ChIP-Seq_HELA_Human2.01206007
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93333281
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.91326214
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91324914
29* GABP_19822575_ChIP-Seq_HepG2_Human1.89931874
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.89743297
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88802920
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88079602
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.85703868
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82107903
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76622487
36* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75841185
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70601347
38FOXP3_21729870_ChIP-Seq_TREG_Human1.70302373
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69624287
40TTF2_22483619_ChIP-Seq_HELA_Human1.68656842
41* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68467932
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63318777
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62784344
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59620778
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.55740800
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51558492
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.48836465
48ELK1_19687146_ChIP-ChIP_HELA_Human1.47781795
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47067264
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46116333
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.44449266
52ZNF263_19887448_ChIP-Seq_K562_Human1.43694962
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.43145946
54KDM5A_27292631_Chip-Seq_BREAST_Human1.40287256
55* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38865491
56* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38811734
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36122933
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35827455
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35220820
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34390707
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30873376
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28701572
63MYC_18940864_ChIP-ChIP_HL60_Human1.28701085
64* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25888221
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.25814409
66CIITA_25753668_ChIP-Seq_RAJI_Human1.25749338
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24707167
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23019435
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22378156
70* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22141067
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19926219
72TFEB_21752829_ChIP-Seq_HELA_Human1.17496890
73OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17321739
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15720315
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14623797
76SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12651349
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11911357
78* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.11417408
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10802332
80* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09779928
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09735942
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09555785
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09521887
84PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08000269
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07499409
86ELK1_22589737_ChIP-Seq_MCF10A_Human1.05242044
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04436037
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04393113
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04259366
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03491581
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03177559
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01612626
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01160904
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00697242
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00449499
96NANOG_21062744_ChIP-ChIP_HESCs_Human0.99757493
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99513120
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99052932
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98754960
100CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98213057
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97305880
102RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95926574
103SOX17_20123909_ChIP-Seq_XEN_Mouse0.95476965
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93221975
105ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91689980
106CLOCK_20551151_ChIP-Seq_293T_Human0.91630961
107RXR_22158963_ChIP-Seq_LIVER_Mouse0.91457172
108* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90772227
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88438141
110NANOG_16153702_ChIP-ChIP_HESCs_Human0.86819194
111CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86502198
112CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85130639
113* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83376868
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81846359
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81714237
116* FOXP1_21924763_ChIP-Seq_HESCs_Human0.81486963
117SOX2_16153702_ChIP-ChIP_HESCs_Human0.78503754

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.21736713
2MP0003693_abnormal_embryo_hatching4.81183369
3MP0004957_abnormal_blastocyst_morpholog4.14336918
4MP0003111_abnormal_nucleus_morphology3.32049497
5MP0003077_abnormal_cell_cycle3.19513009
6MP0010094_abnormal_chromosome_stability3.13676913
7MP0009379_abnormal_foot_pigmentation2.94411308
8MP0001730_embryonic_growth_arrest2.69568492
9MP0008932_abnormal_embryonic_tissue2.64745590
10MP0002139_abnormal_hepatobiliary_system2.46525453
11MP0003705_abnormal_hypodermis_morpholog2.43795614
12MP0001529_abnormal_vocalization2.33847709
13MP0003123_paternal_imprinting2.29408930
14MP0005360_urolithiasis2.29225990
15MP0003718_maternal_effect2.25717800
16MP0003186_abnormal_redox_activity2.17420859
17MP0002938_white_spotting2.14056896
18MP0000372_irregular_coat_pigmentation2.12725758
19MP0008789_abnormal_olfactory_epithelium2.12001023
20MP0006292_abnormal_olfactory_placode2.07189853
21MP0009840_abnormal_foam_cell2.02151867
22MP0010352_gastrointestinal_tract_polyps1.99159514
23MP0006036_abnormal_mitochondrial_physio1.92690149
24MP0008058_abnormal_DNA_repair1.90022784
25MP0000350_abnormal_cell_proliferation1.86963943
26MP0008007_abnormal_cellular_replicative1.85345147
27MP0003221_abnormal_cardiomyocyte_apopto1.82668037
28MP0005085_abnormal_gallbladder_physiolo1.78028057
29MP0003136_yellow_coat_color1.72097063
30MP0008057_abnormal_DNA_replication1.70085356
31MP0000750_abnormal_muscle_regeneration1.69885963
32MP0004084_abnormal_cardiac_muscle1.68988125
33MP0001672_abnormal_embryogenesis/_devel1.68548457
34MP0005380_embryogenesis_phenotype1.68548457
35MP0001697_abnormal_embryo_size1.67819988
36MP0002269_muscular_atrophy1.65978318
37MP0002080_prenatal_lethality1.59696915
38MP0003646_muscle_fatigue1.59656492
39MP0003941_abnormal_skin_development1.59416083
40MP0005499_abnormal_olfactory_system1.57978531
41MP0005394_taste/olfaction_phenotype1.57978531
42MP0006035_abnormal_mitochondrial_morpho1.57580119
43MP0003984_embryonic_growth_retardation1.54458439
44MP0003567_abnormal_fetal_cardiomyocyte1.52237219
45MP0002088_abnormal_embryonic_growth/wei1.51788452
46MP0009053_abnormal_anal_canal1.47995117
47MP0000358_abnormal_cell_content/1.43546373
48MP0004197_abnormal_fetal_growth/weight/1.40930562
49MP0000747_muscle_weakness1.38857770
50MP0010030_abnormal_orbit_morphology1.38225185
51MP0002102_abnormal_ear_morphology1.37103972
52MP0002085_abnormal_embryonic_tissue1.36668878
53MP0010307_abnormal_tumor_latency1.33729498
54MP0000749_muscle_degeneration1.31948400
55MP0002084_abnormal_developmental_patter1.30104087
56MP0005332_abnormal_amino_acid1.25169018
57MP0005365_abnormal_bile_salt1.23413417
58MP0005266_abnormal_metabolism1.22537245
59MP0002086_abnormal_extraembryonic_tissu1.22149647
60MP0009672_abnormal_birth_weight1.22111764
61MP0008995_early_reproductive_senescence1.21466174
62MP0000647_abnormal_sebaceous_gland1.21010077
63MP0008877_abnormal_DNA_methylation1.17285906
64MP0000537_abnormal_urethra_morphology1.17103386
65MP0003786_premature_aging1.15996465
66MP0003011_delayed_dark_adaptation1.11724300
67MP0005330_cardiomyopathy1.08179903
68MP0006072_abnormal_retinal_apoptosis1.08154568
69MP0003315_abnormal_perineum_morphology1.07740623
70MP0001905_abnormal_dopamine_level1.06594251
71MP0002653_abnormal_ependyma_morphology1.05581381
72MP0005083_abnormal_biliary_tract1.04910914
73MP0004133_heterotaxia1.04525544
74MP0005408_hypopigmentation1.03636316
75MP0002234_abnormal_pharynx_morphology1.03066703
76MP0005319_abnormal_enzyme/_coenzyme1.00677735
77MP0004087_abnormal_muscle_fiber0.99632453
78MP0000049_abnormal_middle_ear0.99198301
79MP0003937_abnormal_limbs/digits/tail_de0.98860173
80MP0004036_abnormal_muscle_relaxation0.98741458
81MP0000313_abnormal_cell_death0.98700535
82MP0002095_abnormal_skin_pigmentation0.96790617
83MP0004147_increased_porphyrin_level0.96755886
84MP0005084_abnormal_gallbladder_morpholo0.96347368
85MP0002837_dystrophic_cardiac_calcinosis0.95352387
86MP0008875_abnormal_xenobiotic_pharmacok0.94721061
87MP0002160_abnormal_reproductive_system0.94248863
88MP0002736_abnormal_nociception_after0.93463492
89MP0003119_abnormal_digestive_system0.91579618
90MP0003890_abnormal_embryonic-extraembry0.91019019
91MP0004233_abnormal_muscle_weight0.90703404
92MP0002163_abnormal_gland_morphology0.89846833
93MP0005171_absent_coat_pigmentation0.89767453
94MP0002090_abnormal_vision0.88146429
95MP0003950_abnormal_plasma_membrane0.87534707
96MP0008260_abnormal_autophagy0.87082449
97MP0002233_abnormal_nose_morphology0.86457325
98MP0005395_other_phenotype0.84476363
99MP0005187_abnormal_penis_morphology0.83791498
100MP0002019_abnormal_tumor_incidence0.83702685
101MP0001849_ear_inflammation0.82683135
102MP0002111_abnormal_tail_morphology0.82480125
103MP0003656_abnormal_erythrocyte_physiolo0.82133992
104MP0005023_abnormal_wound_healing0.81788972
105MP0000598_abnormal_liver_morphology0.81168534
106MP0000759_abnormal_skeletal_muscle0.80161855
107MP0001929_abnormal_gametogenesis0.79970019
108MP0002751_abnormal_autonomic_nervous0.79732360
109MP0005389_reproductive_system_phenotype0.78401729
110MP0001727_abnormal_embryo_implantation0.78324273
111MP0001764_abnormal_homeostasis0.77696460
112MP0002106_abnormal_muscle_physiology0.77626392
113MP0001293_anophthalmia0.77190362
114MP0002697_abnormal_eye_size0.77009145
115MP0005501_abnormal_skin_physiology0.76910828
116MP0003566_abnormal_cell_adhesion0.76155189
117MP0010329_abnormal_lipoprotein_level0.75955178
118MP0000733_abnormal_muscle_development0.75262361
119MP0002210_abnormal_sex_determination0.74737315
120MP0009697_abnormal_copulation0.74361752
121MP0000762_abnormal_tongue_morphology0.74221287
122MP0001286_abnormal_eye_development0.73777036
123MP0002332_abnormal_exercise_endurance0.73529220
124MP0003195_calcinosis0.73430615
125MP0000609_abnormal_liver_physiology0.72778711
126MP0000751_myopathy0.72115748
127MP0000653_abnormal_sex_gland0.71524936
128MP0003755_abnormal_palate_morphology0.71333548
129MP0003385_abnormal_body_wall0.70938905
130MP0005384_cellular_phenotype0.70652378
131MP0001346_abnormal_lacrimal_gland0.70595437
132MP0001881_abnormal_mammary_gland0.70452800
133MP0005075_abnormal_melanosome_morpholog0.70075903
134MP0001145_abnormal_male_reproductive0.68621859
135MP0003121_genomic_imprinting0.67973080
136MP0008438_abnormal_cutaneous_collagen0.66531038
137MP0002127_abnormal_cardiovascular_syste0.66346936
138MP0010630_abnormal_cardiac_muscle0.65570579
139MP0002177_abnormal_outer_ear0.65277619
140MP0005391_vision/eye_phenotype0.64370257
141MP0000566_synostosis0.63856728
142MP0001544_abnormal_cardiovascular_syste0.63083702
143MP0005385_cardiovascular_system_phenoty0.63083702
144MP0005253_abnormal_eye_physiology0.61971484
145MP0003942_abnormal_urinary_system0.60742490
146MP0005197_abnormal_uvea_morphology0.60016713
147MP0003938_abnormal_ear_development0.58357072
148MP0001299_abnormal_eye_distance/0.58049381
149MP0002282_abnormal_trachea_morphology0.57634102
150MP0001324_abnormal_eye_pigmentation0.57367854

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.41630969
2Abnormality of glycolysis (HP:0004366)4.06933139
3Increased serum pyruvate (HP:0003542)4.06933139
4Lipid accumulation in hepatocytes (HP:0006561)3.96592685
5Cerebral hypomyelination (HP:0006808)3.87141134
6Multiple enchondromatosis (HP:0005701)3.81925217
7Renal Fanconi syndrome (HP:0001994)3.76045907
8Birth length less than 3rd percentile (HP:0003561)3.56369457
9Increased intramyocellular lipid droplets (HP:0012240)3.47425887
10Hyperglycinemia (HP:0002154)3.45260603
11Breast hypoplasia (HP:0003187)3.43244735
12Abnormality of the anterior horn cell (HP:0006802)3.14970372
13Degeneration of anterior horn cells (HP:0002398)3.14970372
14Hypobetalipoproteinemia (HP:0003563)3.10780104
15Rhabdomyolysis (HP:0003201)3.07393903
16Microvesicular hepatic steatosis (HP:0001414)3.03206920
17Carpal bone hypoplasia (HP:0001498)3.01866225
18Oral leukoplakia (HP:0002745)2.97589367
193-Methylglutaconic aciduria (HP:0003535)2.93357562
20Hyperglycinuria (HP:0003108)2.88396897
21Abnormality of serine family amino acid metabolism (HP:0010894)2.88337456
22Abnormality of glycine metabolism (HP:0010895)2.88337456
23Increased muscle lipid content (HP:0009058)2.81827639
24Exercise-induced muscle cramps (HP:0003710)2.79983841
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.79690772
26Aplasia/Hypoplasia of the sacrum (HP:0008517)2.78809335
27Type I transferrin isoform profile (HP:0003642)2.75585854
28Cerebral edema (HP:0002181)2.74277795
29Respiratory difficulties (HP:0002880)2.72606497
30Trismus (HP:0000211)2.71283874
31Aplastic anemia (HP:0001915)2.66190957
32Abnormality of monocarboxylic acid metabolism (HP:0010996)2.65101952
33Abnormality of serum amino acid levels (HP:0003112)2.64420211
34Progressive muscle weakness (HP:0003323)2.63777400
35Exertional dyspnea (HP:0002875)2.62740815
36Myoglobinuria (HP:0002913)2.62078267
37Hyperammonemia (HP:0001987)2.61083131
38Acute necrotizing encephalopathy (HP:0006965)2.57710429
39Acute encephalopathy (HP:0006846)2.54226508
40Hepatic necrosis (HP:0002605)2.53598933
41CNS demyelination (HP:0007305)2.50934789
42Amniotic constriction ring (HP:0009775)2.49252720
43Abnormality of placental membranes (HP:0011409)2.49252720
44Optic disc pallor (HP:0000543)2.49161289
45Abnormal mitochondria in muscle tissue (HP:0008316)2.48690925
46Abnormality of pyrimidine metabolism (HP:0004353)2.47074865
47Rough bone trabeculation (HP:0100670)2.45044233
48Muscle fiber splitting (HP:0003555)2.41408713
49Nausea (HP:0002018)2.39959337
50Lethargy (HP:0001254)2.39439070
51Selective tooth agenesis (HP:0001592)2.38288033
52Abnormality of aromatic amino acid family metabolism (HP:0004338)2.38269035
53Generalized aminoaciduria (HP:0002909)2.37929087
54Increased serum lactate (HP:0002151)2.37073292
55Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.36845345
56Calcaneovalgus deformity (HP:0001848)2.36765042
57Increased CSF lactate (HP:0002490)2.35772492
58Muscle fiber inclusion bodies (HP:0100299)2.35748881
59Megaloblastic anemia (HP:0001889)2.35607779
60Abnormality of cells of the erythroid lineage (HP:0012130)2.34525429
61Nemaline bodies (HP:0003798)2.33235862
62Colon cancer (HP:0003003)2.33132206
63CNS hypomyelination (HP:0003429)2.32846772
64Impulsivity (HP:0100710)2.29864136
65Angiofibromas (HP:0010615)2.28877531
66Adenoma sebaceum (HP:0009720)2.28877531
67Sparse eyelashes (HP:0000653)2.28874035
68Hepatocellular necrosis (HP:0001404)2.26479615
69Secondary amenorrhea (HP:0000869)2.25285073
70Spastic diplegia (HP:0001264)2.23795462
71Patellar aplasia (HP:0006443)2.21218124
72Pelvic girdle muscle weakness (HP:0003749)2.20872889
73Abnormal protein glycosylation (HP:0012346)2.20334235
74Abnormal glycosylation (HP:0012345)2.20334235
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.20334235
76Abnormal protein N-linked glycosylation (HP:0012347)2.20334235
77Premature ovarian failure (HP:0008209)2.19970507
78Aplasia/Hypoplasia of the patella (HP:0006498)2.19740009
79Pallor (HP:0000980)2.18929652
80Deformed tarsal bones (HP:0008119)2.16940760
81Abnormal cartilage morphology (HP:0002763)2.16680105
82Decreased activity of mitochondrial respiratory chain (HP:0008972)2.15249692
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.15249692
84Abnormality of the labia minora (HP:0012880)2.15214097
85Macrocytic anemia (HP:0001972)2.13295823
86Hypolipoproteinemia (HP:0010981)2.11286995
87Pancytopenia (HP:0001876)2.10976953
88Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.09009019
89Reduced antithrombin III activity (HP:0001976)2.08584502
90Abnormal lung lobation (HP:0002101)2.08417148
91Abnormality of the umbilical cord (HP:0010881)2.08343229
92Abnormality of renal resorption (HP:0011038)2.07358457
93Dicarboxylic aciduria (HP:0003215)2.06664523
94Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06664523
95Mitochondrial inheritance (HP:0001427)2.06513355
96Abnormality of the calcaneus (HP:0008364)2.05717092
97Meckel diverticulum (HP:0002245)2.05678916
98Shoulder girdle muscle weakness (HP:0003547)2.05495669
99X-linked dominant inheritance (HP:0001423)2.05316386
100Reticulocytopenia (HP:0001896)2.03181385
101Glossoptosis (HP:0000162)2.02136589
102Lactic acidosis (HP:0003128)2.01956566
103Microretrognathia (HP:0000308)2.01541865
104Abnormality of fatty-acid metabolism (HP:0004359)2.00814510
105Intrahepatic cholestasis (HP:0001406)1.99558337
106Testicular atrophy (HP:0000029)1.98817984
107Difficulty climbing stairs (HP:0003551)1.96987498
108Respiratory failure (HP:0002878)1.96742873
109Postnatal microcephaly (HP:0005484)1.96298262
110Ependymoma (HP:0002888)1.96049901
111Abnormal number of erythroid precursors (HP:0012131)1.94129551
112Abnormality of the ileum (HP:0001549)1.93876305
113Abnormality of the preputium (HP:0100587)1.93459565
114Hypoglycemic coma (HP:0001325)1.93421754
115Abnormality of methionine metabolism (HP:0010901)1.93236385
116Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92833618
117Abnormality of alanine metabolism (HP:0010916)1.92833618
118Emotional lability (HP:0000712)1.92811136
119Abnormality of sulfur amino acid metabolism (HP:0004339)1.92661004
120Areflexia of lower limbs (HP:0002522)1.91576603
121Distal arthrogryposis (HP:0005684)1.90990673
122Palpitations (HP:0001962)1.90358171
123Abnormality of the hip-girdle musculature (HP:0001445)1.90197075
124Abnormality of the musculature of the pelvis (HP:0001469)1.90197075
125Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.90071871
126Facial cleft (HP:0002006)1.89895435
127Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87802384
128Progressive macrocephaly (HP:0004481)1.86912847
129Leukodystrophy (HP:0002415)1.84181372
130Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.82694939
131Horseshoe kidney (HP:0000085)1.82275524
132Cortical dysplasia (HP:0002539)1.81170128
133Atrophy/Degeneration involving motor neurons (HP:0007373)1.80866116
134Opisthotonus (HP:0002179)1.79886814
135Spastic paraparesis (HP:0002313)1.79760055
136Aplasia/Hypoplasia of the uvula (HP:0010293)1.78757413
137Neoplasm of the pancreas (HP:0002894)1.77905942
138Abnormalities of placenta or umbilical cord (HP:0001194)1.76125547
139Gout (HP:0001997)1.75964348
140Exercise intolerance (HP:0003546)1.75255405
141Methylmalonic aciduria (HP:0012120)1.74865406
142Poor suck (HP:0002033)1.74820247
143Absent radius (HP:0003974)1.74338042
144Hyperalaninemia (HP:0003348)1.73349032
145Abnormal trabecular bone morphology (HP:0100671)1.73222653
146Abnormal gallbladder physiology (HP:0012438)1.68697011
147Cholecystitis (HP:0001082)1.68697011
148Congenital ichthyosiform erythroderma (HP:0007431)1.68334910
149Hypoplastic pelvis (HP:0008839)1.68107003
150Chromsome breakage (HP:0040012)1.67157569
151Blindness (HP:0000618)1.66928988
152Abnormality of urine glucose concentration (HP:0011016)1.66543948
153Glycosuria (HP:0003076)1.66543948
154Ragged-red muscle fibers (HP:0003200)1.66474919
155Hyperphosphaturia (HP:0003109)1.65374379
156Muscle fiber atrophy (HP:0100295)1.61809892
157Hypokinesia (HP:0002375)1.61605299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.22615192
2VRK24.50872308
3NEK13.96836689
4WEE13.80947493
5EIF2AK13.03944261
6TESK22.88401550
7CDC72.71617807
8NME22.37949376
9TESK12.28981281
10LIMK12.28382829
11TSSK62.25550736
12BCKDK2.18434645
13PLK42.00699770
14NEK21.99982464
15EPHA21.89607840
16MAP3K121.86477194
17SRPK11.81411092
18MST41.80301514
19TTK1.77090075
20PDK31.68760945
21PDK41.68760945
22ACVR1B1.62200416
23PLK11.61941379
24BRSK21.60801162
25PLK31.58535879
26SCYL21.57091842
27TRIM281.42307088
28LATS21.40209602
29MAP3K81.39224404
30AURKB1.36259192
31AURKA1.36076161
32EIF2AK31.34700775
33PKN21.33774054
34RPS6KB21.33098264
35TTN1.27666745
36STK161.21951426
37TRIB31.21817071
38BRSK11.20111525
39CSNK1G31.16731047
40OBSCN1.14587544
41PBK1.13895934
42NME11.11938415
43DYRK31.08592604
44PAK41.07777818
45BRAF1.05817642
46PASK1.03462629
47LRRK21.01169917
48PDK21.00705837
49VRK11.00051573
50RPS6KA40.99983300
51MAP3K110.99065006
52TAF10.98043577
53ARAF0.97115921
54CDK80.96211307
55STK38L0.95615554
56TLK10.95473959
57CDK70.94643223
58ZAK0.92062149
59CSNK1G10.91107179
60ILK0.89319929
61KDR0.88380029
62ATR0.88279888
63CSNK1A1L0.87719318
64DAPK10.87629154
65TGFBR10.86879553
66CSNK1G20.85626364
67MAPKAPK30.84585344
68PNCK0.83904528
69CHEK10.83315264
70PAK10.82375624
71CHEK20.81515781
72CDK40.79175473
73PIM20.78493863
74NUAK10.76852147
75MAP2K70.76261452
76MKNK10.73935349
77MST1R0.73030538
78ALK0.71830605
79ABL20.67928096
80CSNK2A20.65206346
81PLK20.64655322
82MINK10.63005249
83MAP4K20.62122307
84CLK10.62078928
85MYLK0.62006058
86MAP3K30.61853310
87MET0.61367627
88CSNK2A10.60660452
89MAP2K30.58347158
90KSR20.58021390
91DYRK20.56852497
92CDK20.56655835
93ERBB40.55544534
94CDK190.54771280
95PRKCI0.53488872
96WNK30.52770242
97DAPK30.52722207
98CCNB10.52715055
99EIF2AK20.52714791
100STK40.51896471
101MUSK0.50685047
102FGFR10.49972260
103EPHB20.49092595
104CSNK1E0.48803949
105STK100.48210058
106PHKG10.48023403
107PHKG20.48023403
108CDK180.45804798
109MKNK20.44281127
110CDK11A0.44275822
111ERBB30.44062980
112IRAK30.42960586
113NEK90.42754549
114CDK150.42556096
115MTOR0.41078986
116MELK0.39097843
117FLT30.38754721
118CDK10.38608015
119MAP2K20.38464681
120EEF2K0.36898641
121BMPR1B0.36823363
122AKT20.36413610
123MAP2K10.36202787
124CDK140.35994321
125ATM0.35982705
126CDK60.34882243
127RPS6KA50.33610847
128TAOK20.33231519
129MAP3K50.32668345
130MAP3K100.32582629
131MAPKAPK50.31991186
132BCR0.26320794

Predicted pathways (KEGG)

RankGene SetZ-score
1* Proteasome_Homo sapiens_hsa030504.23482763
2DNA replication_Homo sapiens_hsa030303.05565890
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86653679
4RNA polymerase_Homo sapiens_hsa030202.81565365
5Ribosome_Homo sapiens_hsa030102.63328973
6RNA transport_Homo sapiens_hsa030132.52900184
7Mismatch repair_Homo sapiens_hsa034302.48206892
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.47928458
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.43516708
10One carbon pool by folate_Homo sapiens_hsa006702.36257445
11Spliceosome_Homo sapiens_hsa030402.33079359
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.29615609
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.24906913
14Pyrimidine metabolism_Homo sapiens_hsa002402.01428273
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.00254799
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.97730726
17Biosynthesis of amino acids_Homo sapiens_hsa012301.94645433
18Carbon metabolism_Homo sapiens_hsa012001.93002778
19Nucleotide excision repair_Homo sapiens_hsa034201.87552021
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.81173552
21Cell cycle_Homo sapiens_hsa041101.70372327
22Base excision repair_Homo sapiens_hsa034101.65279659
23Pyruvate metabolism_Homo sapiens_hsa006201.53774160
24Vitamin B6 metabolism_Homo sapiens_hsa007501.52155320
25Parkinsons disease_Homo sapiens_hsa050121.51430185
26Folate biosynthesis_Homo sapiens_hsa007901.45695778
27Homologous recombination_Homo sapiens_hsa034401.40516742
28Selenocompound metabolism_Homo sapiens_hsa004501.40462230
29Oxidative phosphorylation_Homo sapiens_hsa001901.38717386
30Propanoate metabolism_Homo sapiens_hsa006401.38093843
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.37177194
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34044436
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28384858
34Pentose phosphate pathway_Homo sapiens_hsa000301.25882000
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20681375
36Fatty acid degradation_Homo sapiens_hsa000711.19039285
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.16407025
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16278646
39Huntingtons disease_Homo sapiens_hsa050161.15173889
40Glutathione metabolism_Homo sapiens_hsa004801.12442688
41Sulfur relay system_Homo sapiens_hsa041221.09326530
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08156763
43Phenylalanine metabolism_Homo sapiens_hsa003601.08064990
44Basal transcription factors_Homo sapiens_hsa030221.06771328
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06299689
46Arginine biosynthesis_Homo sapiens_hsa002201.05966508
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04467293
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.02673593
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00269775
50Tyrosine metabolism_Homo sapiens_hsa003500.96118849
51Purine metabolism_Homo sapiens_hsa002300.95187678
52RNA degradation_Homo sapiens_hsa030180.94455712
53Arginine and proline metabolism_Homo sapiens_hsa003300.92128136
54mRNA surveillance pathway_Homo sapiens_hsa030150.90701793
55Fructose and mannose metabolism_Homo sapiens_hsa000510.85417001
56Tryptophan metabolism_Homo sapiens_hsa003800.82541028
57Fatty acid metabolism_Homo sapiens_hsa012120.82443231
58Epstein-Barr virus infection_Homo sapiens_hsa051690.82075095
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81980847
60Systemic lupus erythematosus_Homo sapiens_hsa053220.81548636
61p53 signaling pathway_Homo sapiens_hsa041150.81014405
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81003668
63Butanoate metabolism_Homo sapiens_hsa006500.80154547
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77808455
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77068815
66Sulfur metabolism_Homo sapiens_hsa009200.74717943
67Collecting duct acid secretion_Homo sapiens_hsa049660.72254957
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70606640
69Peroxisome_Homo sapiens_hsa041460.69825810
70beta-Alanine metabolism_Homo sapiens_hsa004100.68290705
71Vibrio cholerae infection_Homo sapiens_hsa051100.68283874
72Nitrogen metabolism_Homo sapiens_hsa009100.66933929
73Oocyte meiosis_Homo sapiens_hsa041140.64054218
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64029514
75Non-homologous end-joining_Homo sapiens_hsa034500.63884145
76N-Glycan biosynthesis_Homo sapiens_hsa005100.60310303
77Alzheimers disease_Homo sapiens_hsa050100.60285166
78Fanconi anemia pathway_Homo sapiens_hsa034600.58878099
79Metabolic pathways_Homo sapiens_hsa011000.58295498
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54055243
81Fatty acid elongation_Homo sapiens_hsa000620.53873533
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51693331
83Chemical carcinogenesis_Homo sapiens_hsa052040.48551958
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48327074
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48171235
86Steroid biosynthesis_Homo sapiens_hsa001000.47114573
87Viral carcinogenesis_Homo sapiens_hsa052030.47049727
88Fat digestion and absorption_Homo sapiens_hsa049750.46715088
89Histidine metabolism_Homo sapiens_hsa003400.43031356
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42448407
91Legionellosis_Homo sapiens_hsa051340.40059444
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38633907
93Cardiac muscle contraction_Homo sapiens_hsa042600.37851434
94Thyroid cancer_Homo sapiens_hsa052160.37623117
95Galactose metabolism_Homo sapiens_hsa000520.37333509
96PPAR signaling pathway_Homo sapiens_hsa033200.36187812
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.35546679
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34298604
99Protein export_Homo sapiens_hsa030600.32669610
100Retinol metabolism_Homo sapiens_hsa008300.27971273
101Bladder cancer_Homo sapiens_hsa052190.26960433
102Regulation of autophagy_Homo sapiens_hsa041400.26278888
103Starch and sucrose metabolism_Homo sapiens_hsa005000.25320084
104Complement and coagulation cascades_Homo sapiens_hsa046100.24963510
105Caffeine metabolism_Homo sapiens_hsa002320.24709432
106Synaptic vesicle cycle_Homo sapiens_hsa047210.23664116
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20967812
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19214104
109Basal cell carcinoma_Homo sapiens_hsa052170.12905304
110Phototransduction_Homo sapiens_hsa047440.07011075
111Hippo signaling pathway_Homo sapiens_hsa043900.06644695
112Shigellosis_Homo sapiens_hsa051310.04280753
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.03723384

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