PSMB9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.35716158
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.35716158
3antigen processing and presentation of endogenous antigen (GO:0019883)7.02175353
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.50666361
5negative regulation of cell killing (GO:0031342)5.31880686
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.31880686
7ribosomal small subunit assembly (GO:0000028)4.90200737
8cytidine metabolic process (GO:0046087)4.87056794
9cytidine catabolic process (GO:0006216)4.87056794
10cytidine deamination (GO:0009972)4.87056794
11positive regulation of gamma-delta T cell activation (GO:0046645)4.83902330
12pyrimidine ribonucleoside catabolic process (GO:0046133)4.30693230
13type I interferon signaling pathway (GO:0060337)4.26824147
14cellular response to type I interferon (GO:0071357)4.26824147
15response to type I interferon (GO:0034340)4.26482953
16antigen processing and presentation via MHC class Ib (GO:0002475)4.20377720
17regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.16872926
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.13271619
19response to interferon-beta (GO:0035456)3.98195199
20cellular response to interferon-beta (GO:0035458)3.87011500
21positive T cell selection (GO:0043368)3.83269481
22regulation of B cell receptor signaling pathway (GO:0050855)3.80354137
23viral transcription (GO:0019083)3.79196554
24positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.74354261
25detection of bacterium (GO:0016045)3.73740928
26regulation of natural killer cell mediated immunity (GO:0002715)3.67081223
27regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.67081223
28immunoglobulin mediated immune response (GO:0016064)3.65159331
29positive regulation of B cell differentiation (GO:0045579)3.63005898
30detection of other organism (GO:0098543)3.61002264
31translational termination (GO:0006415)3.57208313
32negative thymic T cell selection (GO:0045060)3.50168746
33regulation of gamma-delta T cell differentiation (GO:0045586)3.50110776
34regulation of leukocyte mediated cytotoxicity (GO:0001910)3.49313512
35NIK/NF-kappaB signaling (GO:0038061)3.48903604
36positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.48332787
37regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.47561466
38regulation of B cell differentiation (GO:0045577)3.45532086
39defense response to protozoan (GO:0042832)3.45283078
40negative T cell selection (GO:0043383)3.43903022
41interferon-gamma-mediated signaling pathway (GO:0060333)3.43758484
42Arp2/3 complex-mediated actin nucleation (GO:0034314)3.43058992
43cellular response to zinc ion (GO:0071294)3.40406179
44DNA deamination (GO:0045006)3.40045381
45positive regulation of antigen processing and presentation (GO:0002579)3.38607999
46regulation of gamma-delta T cell activation (GO:0046643)3.31890282
47negative regulation of lymphocyte mediated immunity (GO:0002707)3.31662859
48response to interferon-alpha (GO:0035455)3.29934229
49myeloid dendritic cell activation (GO:0001773)3.29063583
50regulation of interleukin-12 biosynthetic process (GO:0045075)3.28893513
51response to protozoan (GO:0001562)3.28585959
52positive regulation by symbiont of host defense response (GO:0052509)3.27659004
53modulation by symbiont of host defense response (GO:0052031)3.27659004
54modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.27659004
55modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.27659004
56positive regulation by organism of defense response of other organism involved in symbiotic interact3.27659004
57modulation by symbiont of host immune response (GO:0052553)3.27659004
58regulation of cell killing (GO:0031341)3.26384273
59regulation of tolerance induction (GO:0002643)3.26022431
60regulation of dendritic cell antigen processing and presentation (GO:0002604)3.25567917
61T cell migration (GO:0072678)3.23953169
62positive regulation of cell killing (GO:0031343)3.22461005
63antigen receptor-mediated signaling pathway (GO:0050851)3.22419459
64leukocyte aggregation (GO:0070486)3.21435988
65B cell receptor signaling pathway (GO:0050853)3.20207983
66mast cell activation (GO:0045576)3.19786706
67negative regulation of leukocyte mediated immunity (GO:0002704)3.17092754
68SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.16433291
69actin nucleation (GO:0045010)3.15268603
70T cell receptor signaling pathway (GO:0050852)3.14631393
71positive regulation of interferon-alpha production (GO:0032727)3.13000902
72regulation of type I interferon-mediated signaling pathway (GO:0060338)3.11193546
73B cell mediated immunity (GO:0019724)3.11004088
74negative regulation of interleukin-12 production (GO:0032695)3.09321855
75ribosomal small subunit biogenesis (GO:0042274)3.08833620
76neutrophil activation involved in immune response (GO:0002283)3.08571293
77positive regulation of tolerance induction (GO:0002645)3.08376189
78cotranslational protein targeting to membrane (GO:0006613)3.07158580
79protein targeting to ER (GO:0045047)3.06757025
80translational elongation (GO:0006414)3.05231512
81regulation of alpha-beta T cell proliferation (GO:0046640)3.04020192
82regulation of antigen processing and presentation (GO:0002577)3.02156797
83regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.02035330
84negative regulation of T cell mediated immunity (GO:0002710)2.99254348
85positive regulation of natural killer cell mediated immunity (GO:0002717)2.98573314
86regulation of RIG-I signaling pathway (GO:0039535)2.98500268
87response to interleukin-15 (GO:0070672)2.96906991
88interferon-gamma production (GO:0032609)2.96687964
89regulation of interferon-alpha production (GO:0032647)2.96588265
90regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.95073871
91tolerance induction (GO:0002507)2.95017428
92macrophage activation involved in immune response (GO:0002281)2.94675251
93myeloid dendritic cell differentiation (GO:0043011)2.92199976
94dendritic cell chemotaxis (GO:0002407)2.91649593
95protein localization to endoplasmic reticulum (GO:0070972)2.91117318
96positive thymic T cell selection (GO:0045059)2.91093648
97myeloid cell activation involved in immune response (GO:0002275)2.90587944
98establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90359001
99negative regulation of T cell apoptotic process (GO:0070233)2.88801559
100regulation of T cell receptor signaling pathway (GO:0050856)2.88715803
101negative regulation of innate immune response (GO:0045824)2.87968435
102cellular response to exogenous dsRNA (GO:0071360)2.87173272
103positive regulation of natural killer cell differentiation (GO:0032825)2.86795084
104positive regulation of T cell mediated immunity (GO:0002711)2.86114152
105detection of external biotic stimulus (GO:0098581)2.85015311
106response to interferon-gamma (GO:0034341)2.84973323
107lymphocyte chemotaxis (GO:0048247)2.84638574
108negative regulation of phagocytosis (GO:0050765)2.84231997
109respiratory burst (GO:0045730)2.83379435
110T cell homeostasis (GO:0043029)2.83330855
111granulocyte activation (GO:0036230)2.83238222
112regulation of response to interferon-gamma (GO:0060330)2.81559508
113positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.78209127
114viral life cycle (GO:0019058)2.77930261
115thymic T cell selection (GO:0045061)2.76408190
116mature B cell differentiation (GO:0002335)2.75408860
117cellular response to interleukin-15 (GO:0071350)2.71125561
118telomere maintenance via semi-conservative replication (GO:0032201)2.70398323
119nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.70036666
120negative regulation of viral genome replication (GO:0045071)2.69289037
121positive regulation of defense response to virus by host (GO:0002230)2.68667653
122mature B cell differentiation involved in immune response (GO:0002313)2.68567615
123positive regulation of alpha-beta T cell proliferation (GO:0046641)2.68219178
124natural killer cell activation (GO:0030101)2.67148884
125positive regulation of isotype switching (GO:0045830)2.66219087
126regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.64447238
127regulation of interferon-beta biosynthetic process (GO:0045357)2.62963438
128T cell selection (GO:0045058)2.61330605
129cellular protein complex disassembly (GO:0043624)2.60642151
130positive regulation of T cell mediated cytotoxicity (GO:0001916)2.60512371
131neutrophil activation (GO:0042119)2.59280645
132regulation of hypersensitivity (GO:0002883)2.58613470
133negative regulation of B cell apoptotic process (GO:0002903)2.58503456
134cellular response to interferon-gamma (GO:0071346)2.57479724
135regulation of T cell mediated cytotoxicity (GO:0001914)2.54963526
136T cell costimulation (GO:0031295)2.54551790
137JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.53409713
138regulation of T cell tolerance induction (GO:0002664)2.53363575
139regulation of regulatory T cell differentiation (GO:0045589)2.53102753
140natural killer cell mediated cytotoxicity (GO:0042267)2.51874753
141natural killer cell mediated immunity (GO:0002228)2.51874753
142regulation of necroptotic process (GO:0060544)2.51254637
143lymphocyte costimulation (GO:0031294)2.50948383
144positive regulation of macrophage differentiation (GO:0045651)2.49245509

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human5.39852061
2E2F7_22180533_ChIP-Seq_HELA_Human4.87170635
3* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.27999610
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.03296414
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.64324101
6* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.56412841
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.20065945
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.17132754
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.05973324
10* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.72119736
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.64011595
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.58244644
13SCL_19346495_ChIP-Seq_HPC-7_Human2.46280668
14* IRF8_27001747_Chip-Seq_BMDM_Mouse2.45825519
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41095526
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.39608465
17MYC_22102868_ChIP-Seq_BL_Human2.34212914
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.29828810
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.29542708
20VDR_21846776_ChIP-Seq_THP-1_Human2.27747168
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.27440511
22SPI1_23547873_ChIP-Seq_NB4_Human2.26147465
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25343996
24* MYB_26560356_Chip-Seq_TH2_Human2.25296452
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.24690241
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24162616
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24135333
28MAF_26560356_Chip-Seq_TH1_Human2.18150398
29MYB_26560356_Chip-Seq_TH1_Human1.99632403
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.95746347
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.90244733
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.89935988
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.87183730
34VDR_24763502_ChIP-Seq_THP-1_Human1.84118930
35GATA1_22025678_ChIP-Seq_K562_Human1.80881034
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.79874319
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76651112
38RUNX_20019798_ChIP-Seq_JUKART_Human1.74875435
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73502044
40UTX_26944678_Chip-Seq_JUKART_Human1.73083839
41SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.69010584
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.65548883
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58473395
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.57293886
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53295228
46* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52085666
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50031671
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.49494607
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49164901
50MAF_26560356_Chip-Seq_TH2_Human1.47018826
51BCL6_27268052_Chip-Seq_Bcells_Human1.46482648
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44919104
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44835976
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44559657
55VDR_23849224_ChIP-Seq_CD4+_Human1.43346483
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41608463
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40783990
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.38013578
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35500375
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.34652406
61TCF7_22412390_ChIP-Seq_EML_Mouse1.31290006
62GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.31134684
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.30987010
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30846354
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26467373
66GATA3_27048872_Chip-Seq_THYMUS_Human1.26351475
67FOXP3_21729870_ChIP-Seq_TREG_Human1.25684940
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25544388
69SPI1_23127762_ChIP-Seq_K562_Human1.24382001
70EST1_17652178_ChIP-ChIP_JURKAT_Human1.23115474
71VDR_24787735_ChIP-Seq_THP-1_Human1.22399046
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21913879
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20714412
74FOXM1_23109430_ChIP-Seq_U2OS_Human1.20673896
75PU_27001747_Chip-Seq_BMDM_Mouse1.18202596
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16542794
77BCOR_27268052_Chip-Seq_Bcells_Human1.12431610
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11852871
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11251529
80* CIITA_25753668_ChIP-Seq_RAJI_Human1.11080312
81MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10904282
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10505787
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10098329
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08716072
85P300_27268052_Chip-Seq_Bcells_Human1.07256938
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.06946868
87EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05841209
88GATA3_26560356_Chip-Seq_TH2_Human1.05630373
89PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04342509
90XRN2_22483619_ChIP-Seq_HELA_Human1.03259992
91JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02832613
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99850181
93STAT1_20625510_ChIP-Seq_HELA_Human0.99268559
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98096269
95ETS1_20019798_ChIP-Seq_JURKAT_Human0.97775693
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97615152
97SRF_21415370_ChIP-Seq_HL-1_Mouse0.96752112
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96597254
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95888573
100CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94894790
101FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94744329
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94456451
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93960993
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93172077
105PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92334134
106MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91074573
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91029369
108RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90968740
109ELK3_25401928_ChIP-Seq_HUVEC_Human0.90652177
110SPI1_20517297_ChIP-Seq_HL60_Human0.89687260
111* ELK1_19687146_ChIP-ChIP_HELA_Human0.89304616
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.89084588
113EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88737829
114MYC_19079543_ChIP-ChIP_MESCs_Mouse0.88713125
115E2F1_21310950_ChIP-Seq_MCF-7_Human0.88634661
116KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88311308
117Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87231876
118PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86982461
119CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85482356
120DCP1A_22483619_ChIP-Seq_HELA_Human0.85461164
121NANOG_20526341_ChIP-Seq_ESCs_Human0.85031689
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81499506
123PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80835082
124E2F1_20622854_ChIP-Seq_HELA_Human0.80623173
125TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80142583
126CTCF_26484167_Chip-Seq_Bcells_Mouse0.78708428
127* GATA3_26560356_Chip-Seq_TH1_Human0.78501278
128IKZF1_21737484_ChIP-ChIP_HCT116_Human0.77462267
129CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.76335583
130SMRT_27268052_Chip-Seq_Bcells_Human0.74979885

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.94636626
2MP0005671_abnormal_response_to3.60356305
3MP0000685_abnormal_immune_system3.56989160
4MP0009785_altered_susceptibility_to3.44253874
5MP0001800_abnormal_humoral_immune3.02170795
6MP0003763_abnormal_thymus_physiology2.94138246
7* MP0001790_abnormal_immune_system2.86887780
8* MP0005387_immune_system_phenotype2.86887780
9* MP0005025_abnormal_response_to2.86833962
10MP0005000_abnormal_immune_tolerance2.82275792
11MP0003436_decreased_susceptibility_to2.79234306
12MP0002396_abnormal_hematopoietic_system2.76857227
13MP0002166_altered_tumor_susceptibility2.76407204
14MP0002148_abnormal_hypersensitivity_rea2.75680231
15MP0002452_abnormal_antigen_presenting2.72147301
16MP0002723_abnormal_immune_serum2.67211247
17MP0002420_abnormal_adaptive_immunity2.60378842
18MP0001819_abnormal_immune_cell2.59499508
19MP0003724_increased_susceptibility_to2.58179862
20MP0002419_abnormal_innate_immunity2.40561013
21MP0002398_abnormal_bone_marrow2.39467699
22MP0002006_tumorigenesis2.29689915
23* MP0000716_abnormal_immune_system2.19173486
24MP0001853_heart_inflammation2.14820638
25MP0005464_abnormal_platelet_physiology2.06262073
26MP0010155_abnormal_intestine_physiology2.05066241
27MP0009333_abnormal_splenocyte_physiolog1.97142326
28MP0000689_abnormal_spleen_morphology1.96849234
29MP0002405_respiratory_system_inflammati1.96728482
30MP0006082_CNS_inflammation1.94495848
31MP0002722_abnormal_immune_system1.91528900
32MP0001873_stomach_inflammation1.88800352
33* MP0002429_abnormal_blood_cell1.87300763
34MP0001545_abnormal_hematopoietic_system1.80724481
35MP0005397_hematopoietic_system_phenotyp1.80724481
36MP0001845_abnormal_inflammatory_respons1.77817298
37MP0004510_myositis1.76881287
38MP0004947_skin_inflammation1.67190290
39MP0004808_abnormal_hematopoietic_stem1.66279082
40MP0003303_peritoneal_inflammation1.66041666
41MP0005174_abnormal_tail_pigmentation1.60221724
42MP0000703_abnormal_thymus_morphology1.55751648
43MP0003866_abnormal_defecation1.53891159
44MP0008469_abnormal_protein_level1.50882299
45MP0003806_abnormal_nucleotide_metabolis1.49004296
46MP0000465_gastrointestinal_hemorrhage1.44614611
47MP0000490_abnormal_crypts_of1.43088422
48MP0003300_gastrointestinal_ulcer1.38005002
49MP0000858_altered_metastatic_potential1.34897890
50MP0001533_abnormal_skeleton_physiology1.29280388
51MP0005310_abnormal_salivary_gland1.28971104
52MP0003693_abnormal_embryo_hatching1.23566964
53MP0003191_abnormal_cellular_cholesterol1.22346610
54MP0009764_decreased_sensitivity_to1.22161695
55MP0002277_abnormal_respiratory_mucosa1.21420710
56MP0005075_abnormal_melanosome_morpholog1.20126623
57MP0009278_abnormal_bone_marrow1.19097123
58MP0008057_abnormal_DNA_replication1.17776823
59MP0010094_abnormal_chromosome_stability1.12108131
60MP0003448_altered_tumor_morphology1.10110262
61MP0002933_joint_inflammation1.09877730
62* MP0002019_abnormal_tumor_incidence1.08131755
63MP0002138_abnormal_hepatobiliary_system1.04475192
64MP0005058_abnormal_lysosome_morphology1.03392505
65MP0002095_abnormal_skin_pigmentation1.00596817
66MP0008007_abnormal_cellular_replicative0.96310721
67MP0009763_increased_sensitivity_to0.92488590
68MP0003045_fibrosis0.90672864
69MP0000343_altered_response_to0.89927582
70MP0003077_abnormal_cell_cycle0.86129954
71MP0009840_abnormal_foam_cell0.84941137
72MP0003186_abnormal_redox_activity0.84889196
73MP0002132_abnormal_respiratory_system0.83377731
74MP0001348_abnormal_lacrimal_gland0.81529542
75MP0003172_abnormal_lysosome_physiology0.80096177
76MP0008058_abnormal_DNA_repair0.78029641
77MP0009379_abnormal_foot_pigmentation0.75140759
78MP0003183_abnormal_peptide_metabolism0.74555963
79MP0001986_abnormal_taste_sensitivity0.74061238
80MP0000015_abnormal_ear_pigmentation0.73088229
81MP0004883_abnormal_blood_vessel0.72557363
82MP0004381_abnormal_hair_follicle0.71966704
83MP0002693_abnormal_pancreas_physiology0.71833258
84MP0005390_skeleton_phenotype0.71444775
85MP0004957_abnormal_blastocyst_morpholog0.71246763
86MP0006054_spinal_hemorrhage0.70778530
87MP0003252_abnormal_bile_duct0.69987850
88MP0010352_gastrointestinal_tract_polyps0.69742717
89MP0002254_reproductive_system_inflammat0.69082285
90MP0002998_abnormal_bone_remodeling0.68785525
91MP0008872_abnormal_physiological_respon0.66443315
92MP0001851_eye_inflammation0.66116408
93MP0003075_altered_response_to0.65496768
94MP0001663_abnormal_digestive_system0.65332554
95MP0000604_amyloidosis0.65186492
96MP0005645_abnormal_hypothalamus_physiol0.64650934
97MP0000313_abnormal_cell_death0.64131537
98MP0009765_abnormal_xenobiotic_induced0.62963000
99MP0004782_abnormal_surfactant_physiolog0.62193761
100MP0010307_abnormal_tumor_latency0.62170421
101MP0009643_abnormal_urine_homeostasis0.62148372
102MP0000609_abnormal_liver_physiology0.61274374
103MP0005164_abnormal_response_to0.60143453
104MP0003656_abnormal_erythrocyte_physiolo0.58432631
105MP0002876_abnormal_thyroid_physiology0.58168712
106MP0002136_abnormal_kidney_physiology0.58028384
107MP0003646_muscle_fatigue0.57389680
108MP0002163_abnormal_gland_morphology0.57098367
109MP0005084_abnormal_gallbladder_morpholo0.57070095
110MP0003943_abnormal_hepatobiliary_system0.57021032
111MP0005360_urolithiasis0.56358675
112MP0000598_abnormal_liver_morphology0.56031623
113MP0000249_abnormal_blood_vessel0.55679624
114MP0005319_abnormal_enzyme/_coenzyme0.53954812
115MP0005166_decreased_susceptibility_to0.53640931
116MP0003111_abnormal_nucleus_morphology0.53042531
117MP0001191_abnormal_skin_condition0.52758547
118MP0005584_abnormal_enzyme/coenzyme_acti0.52149034
119MP0005023_abnormal_wound_healing0.52009664
120MP0005381_digestive/alimentary_phenotyp0.51822216
121MP0008873_increased_physiological_sensi0.51190314
122MP0008875_abnormal_xenobiotic_pharmacok0.51125125
123MP0001919_abnormal_reproductive_system0.49901072
124MP0003795_abnormal_bone_structure0.48793136
125MP0008874_decreased_physiological_sensi0.48417279
126MP0001765_abnormal_ion_homeostasis0.47963762
127MP0006036_abnormal_mitochondrial_physio0.47946755
128MP0008260_abnormal_autophagy0.47339266

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)5.72778284
2Elevated erythrocyte sedimentation rate (HP:0003565)5.47126182
3Recurrent abscess formation (HP:0002722)4.75098025
4Recurrent bronchitis (HP:0002837)4.67731087
5Eczematoid dermatitis (HP:0000976)4.54839430
6Myositis (HP:0100614)4.50389765
7Recurrent bacterial skin infections (HP:0005406)4.33106931
8IgM deficiency (HP:0002850)4.28796766
9Thrombocytosis (HP:0001894)4.22590087
10Nasal polyposis (HP:0100582)4.12079138
11Recurrent viral infections (HP:0004429)4.09757429
12Recurrent fungal infections (HP:0002841)3.98069322
13Abnormality of the nasal mucosa (HP:0000433)3.72822177
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.72481823
15Agammaglobulinemia (HP:0004432)3.68665428
16Panhypogammaglobulinemia (HP:0003139)3.65156473
17Chronic mucocutaneous candidiasis (HP:0002728)3.54991850
18Recurrent cutaneous fungal infections (HP:0011370)3.54991850
19Abnormality of T cell physiology (HP:0011840)3.51437508
20Abnormality of T cells (HP:0002843)3.47993849
21Meningitis (HP:0001287)3.47307242
22Recurrent skin infections (HP:0001581)3.42955631
23Mediastinal lymphadenopathy (HP:0100721)3.29540861
24Vasculitis (HP:0002633)3.27191647
25Abnormality of T cell number (HP:0011839)3.27091208
26IgG deficiency (HP:0004315)3.24478526
27Autoimmune thrombocytopenia (HP:0001973)3.20160642
28Cellulitis (HP:0100658)3.18895953
29T lymphocytopenia (HP:0005403)3.17456802
30Orchitis (HP:0100796)3.14740754
31Petechiae (HP:0000967)3.14130261
32Chronic sinusitis (HP:0011109)3.11333180
33Abnormality of cells of the erythroid lineage (HP:0012130)3.09051714
34Abnormal number of erythroid precursors (HP:0012131)3.06274719
35Recurrent gram-negative bacterial infections (HP:0005420)3.00844351
36Reticulocytopenia (HP:0001896)2.96665671
37Retrobulbar optic neuritis (HP:0100654)2.95322110
38Optic neuritis (HP:0100653)2.95322110
39Inflammation of the large intestine (HP:0002037)2.92194357
40Abnormality of cells of the lymphoid lineage (HP:0012140)2.89530589
41Lymphopenia (HP:0001888)2.88510466
42Gastrointestinal inflammation (HP:0004386)2.84848251
43Pustule (HP:0200039)2.84806457
44Interstitial pulmonary disease (HP:0006530)2.84550350
45Abnormality of macrophages (HP:0004311)2.84500716
46B lymphocytopenia (HP:0010976)2.83994451
47Abnormality of B cell number (HP:0010975)2.83994451
48Obstructive lung disease (HP:0006536)2.80276499
49Chronic obstructive pulmonary disease (HP:0006510)2.80276499
50Colitis (HP:0002583)2.78945501
51Hypergammaglobulinemia (HP:0010702)2.77884340
52Gastrointestinal stroma tumor (HP:0100723)2.71272743
53Abnormality of the pleura (HP:0002103)2.67126691
54Severe combined immunodeficiency (HP:0004430)2.66949710
55Recurrent sinusitis (HP:0011108)2.63951674
56Encephalitis (HP:0002383)2.63415750
57Bronchitis (HP:0012387)2.62274743
58Increased IgE level (HP:0003212)2.60703071
59Autoimmune hemolytic anemia (HP:0001890)2.60487293
60Combined immunodeficiency (HP:0005387)2.59572327
61Thyroiditis (HP:0100646)2.59060443
62Stomatitis (HP:0010280)2.57067554
63Hypoproteinemia (HP:0003075)2.56361803
64Eosinophilia (HP:0001880)2.53182611
65Gangrene (HP:0100758)2.52679032
66Leukocytosis (HP:0001974)2.50025916
67Granulocytopenia (HP:0001913)2.48941364
68Increased IgM level (HP:0003496)2.47957595
69Joint swelling (HP:0001386)2.47587210
70IgA deficiency (HP:0002720)2.47110616
71Spontaneous hematomas (HP:0007420)2.46142315
72Pulmonary embolism (HP:0002204)2.44273234
73Abnormality of eosinophils (HP:0001879)2.43625586
74Prolonged bleeding time (HP:0003010)2.42462201
75Chronic diarrhea (HP:0002028)2.41076227
76Hypoplasia of the thymus (HP:0000778)2.38775755
77Basal ganglia calcification (HP:0002135)2.38049770
78Epistaxis (HP:0000421)2.37385388
79Pulmonary infiltrates (HP:0002113)2.37181342
80Lymphoma (HP:0002665)2.37136434
81Hemoptysis (HP:0002105)2.37009143
82Abnormality of the prostate (HP:0008775)2.36275685
83Periodontitis (HP:0000704)2.32408940
84Anorexia (HP:0002039)2.29568394
85Vacuolated lymphocytes (HP:0001922)2.28470220
86Keratoconjunctivitis sicca (HP:0001097)2.25821316
87Emphysema (HP:0002097)2.25213484
88Gingivitis (HP:0000230)2.24491865
89Gingival bleeding (HP:0000225)2.24199646
90Hypochromic anemia (HP:0001931)2.23973472
91Recurrent lower respiratory tract infections (HP:0002783)2.23019792
92Osteomyelitis (HP:0002754)2.22970414
93Gastrointestinal infarctions (HP:0005244)2.21823959
94Pallor (HP:0000980)2.21752675
95Recurrent pneumonia (HP:0006532)2.21523162
96Skin ulcer (HP:0200042)2.21342413
97Poikiloderma (HP:0001029)2.21228455
98Arterial thrombosis (HP:0004420)2.19026733
99Aplastic anemia (HP:0001915)2.17258837
100Abnormality of the fingertips (HP:0001211)2.15347107
101Keratoconjunctivitis (HP:0001096)2.13487945
102Skin rash (HP:0000988)2.13105162
103Urticaria (HP:0001025)2.09501211
104Pulmonary fibrosis (HP:0002206)2.09378849
105Acute hepatic failure (HP:0006554)2.09244493
106Sepsis (HP:0100806)2.08086422
107Neutropenia (HP:0001875)2.08018722
108Papilloma (HP:0012740)2.05025983
109Verrucae (HP:0200043)2.05025983
110Chest pain (HP:0100749)2.03712520
111Purpura (HP:0000979)2.03471418
112Abnormal platelet function (HP:0011869)2.01099325
113Glomerulopathy (HP:0100820)1.98708993
114Arthralgia (HP:0002829)1.96561685
115Polyneuropathy (HP:0001271)1.96275260
116Systemic lupus erythematosus (HP:0002725)1.95446957
117Abnormality of the pericardium (HP:0001697)1.95091840
118Prostate neoplasm (HP:0100787)1.92261771
119Restrictive lung disease (HP:0002091)1.91818622

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.49457959
2TYK23.05850405
3KIT3.00547130
4JAK32.74455232
5TBK12.68121721
6MAP3K142.64397189
7IKBKE2.62842934
8BLK2.60727678
9TXK2.51286466
10NME22.37889078
11IRAK42.35684741
12TEC2.30217487
13BTK2.24223144
14ZAP702.15740788
15CSF1R1.90483603
16SYK1.87849773
17FGFR41.85287251
18FLT31.82188998
19IKBKB1.76813544
20ERN11.73347573
21JAK11.72188390
22PIM21.69182324
23VRK21.58889806
24KDR1.58506221
25ITK1.53304033
26STK101.41606420
27LRRK21.39077554
28STK161.38720017
29BCKDK1.38223046
30LCK1.34916881
31BMPR21.31662007
32GRK61.30429969
33IRAK31.28542625
34EEF2K1.28113062
35TAOK31.26871727
36MAP3K121.26712003
37NLK1.20910500
38LYN1.18557179
39ACVR1B1.13770434
40GRK71.12093360
41CLK11.11902954
42MAP3K131.11677438
43RPS6KA41.11553061
44MAP3K101.10863331
45FGFR31.10751926
46HCK1.09706242
47PIM11.08866564
48TGFBR21.07467426
49CSK1.07103856
50MAP2K31.07041650
51RIPK41.04508423
52FES1.01712999
53MST40.98760123
54TESK10.95842919
55TGFBR10.95611328
56WEE10.94558827
57NEK90.91905753
58CHUK0.91663633
59PKN20.83642396
60FGR0.79050999
61JAK20.77926040
62RPS6KB20.77171339
63VRK10.75442758
64ZAK0.73708792
65FRK0.72089021
66EPHB10.71646999
67MATK0.70708302
68TESK20.70020221
69BRSK20.69393134
70NUAK10.68721349
71STK40.67494617
72CDK40.67371911
73NEK20.65683002
74SCYL20.64412804
75FYN0.63113653
76PDK10.62355529
77MAPK110.62176105
78EIF2AK10.62171104
79EIF2AK30.61909114
80PRKG20.59466453
81MAP3K30.57250067
82SIK30.56838159
83PIK3CG0.55585721
84EPHA30.53442854
85EIF2AK20.51949607
86SIK20.51740991
87PRKCQ0.51504090
88ATR0.49749750
89GRK50.49352459
90CDC70.49025242
91MARK30.48908063
92DAPK10.45933017
93HIPK20.45092355
94TNK20.45009755
95PRPF4B0.44285474
96GRK10.43327804
97IRAK10.41353417
98RPS6KA60.41146936
99MAP3K50.40826862
100ADRBK20.40669403
101PRKCD0.40325633
102MYLK0.40167305
103TLK10.40129053
104MAPK40.40112142
105TAOK20.39061685
106MAP2K60.38973768
107CCNB10.38610476
108MAP4K20.38072881
109TAOK10.37172999
110BUB10.36446448
111MAPKAPK20.35720598
112CAMKK20.35137140
113ABL10.34721981
114LIMK10.34271447
115MAP3K110.33915624
116CDK190.33607556
117PTK2B0.33562448
118CDK60.33356322
119IGF1R0.32816327
120MAP3K10.31518248
121ADRBK10.31330044
122RPS6KA50.30993946
123ILK0.30951533
124MAP3K80.30706963
125RAF10.29888549
126OXSR10.29729615
127MAPKAPK30.29625537
128DYRK30.29469341
129PASK0.28816773
130INSR0.27740215
131MAPK120.27608613
132PRKCH0.25124270
133MAP2K20.23320134
134PDPK10.21451819
135MAPK70.20576400

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.04068293
2Ribosome_Homo sapiens_hsa030102.98691429
3DNA replication_Homo sapiens_hsa030302.91388927
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.76817457
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.66432175
6Antigen processing and presentation_Homo sapiens_hsa046122.59654871
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.46217888
8Leishmaniasis_Homo sapiens_hsa051402.44872523
9Measles_Homo sapiens_hsa051622.43373767
10Allograft rejection_Homo sapiens_hsa053302.28149387
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.18309784
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11216256
13B cell receptor signaling pathway_Homo sapiens_hsa046622.06501720
14Graft-versus-host disease_Homo sapiens_hsa053322.05366214
15Mismatch repair_Homo sapiens_hsa034302.01805269
16Herpes simplex infection_Homo sapiens_hsa051681.99915716
17Base excision repair_Homo sapiens_hsa034101.94987740
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.92821911
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81113099
20Hematopoietic cell lineage_Homo sapiens_hsa046401.79239417
21Osteoclast differentiation_Homo sapiens_hsa043801.78963827
22Homologous recombination_Homo sapiens_hsa034401.57723208
23Influenza A_Homo sapiens_hsa051641.56264321
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.55782251
25Legionellosis_Homo sapiens_hsa051341.54302315
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.50693491
27T cell receptor signaling pathway_Homo sapiens_hsa046601.47136373
28Pertussis_Homo sapiens_hsa051331.43333268
29Staphylococcus aureus infection_Homo sapiens_hsa051501.36129151
30Toxoplasmosis_Homo sapiens_hsa051451.30807936
31* Proteasome_Homo sapiens_hsa030501.29720811
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.28791639
33Apoptosis_Homo sapiens_hsa042101.25142069
34Asthma_Homo sapiens_hsa053101.21137079
35Non-homologous end-joining_Homo sapiens_hsa034501.19801310
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18786087
37Nucleotide excision repair_Homo sapiens_hsa034201.17193095
38Malaria_Homo sapiens_hsa051441.17044202
39Autoimmune thyroid disease_Homo sapiens_hsa053201.16038641
40Tuberculosis_Homo sapiens_hsa051521.15372557
41Shigellosis_Homo sapiens_hsa051311.14739365
42Other glycan degradation_Homo sapiens_hsa005111.13669364
43TNF signaling pathway_Homo sapiens_hsa046681.11842605
44Hepatitis B_Homo sapiens_hsa051611.11415510
45Viral myocarditis_Homo sapiens_hsa054161.07986424
46Pyrimidine metabolism_Homo sapiens_hsa002401.07183602
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04914283
48Chemokine signaling pathway_Homo sapiens_hsa040621.04214682
49Caffeine metabolism_Homo sapiens_hsa002321.03964212
50Acute myeloid leukemia_Homo sapiens_hsa052211.00957215
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97402964
52African trypanosomiasis_Homo sapiens_hsa051430.94112362
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93095822
54Spliceosome_Homo sapiens_hsa030400.91464785
55Epstein-Barr virus infection_Homo sapiens_hsa051690.89727015
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.89500453
57Type I diabetes mellitus_Homo sapiens_hsa049400.88655462
58Hepatitis C_Homo sapiens_hsa051600.86979867
59p53 signaling pathway_Homo sapiens_hsa041150.82248321
60Salmonella infection_Homo sapiens_hsa051320.79278750
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78054963
62Platelet activation_Homo sapiens_hsa046110.76665117
63Pentose phosphate pathway_Homo sapiens_hsa000300.75425937
64One carbon pool by folate_Homo sapiens_hsa006700.73710289
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73599886
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.69013565
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68822754
68Viral carcinogenesis_Homo sapiens_hsa052030.68684145
69Oxidative phosphorylation_Homo sapiens_hsa001900.64604592
70HTLV-I infection_Homo sapiens_hsa051660.61455780
71Protein export_Homo sapiens_hsa030600.59887353
72RNA polymerase_Homo sapiens_hsa030200.58415573
73RNA degradation_Homo sapiens_hsa030180.56676554
74Parkinsons disease_Homo sapiens_hsa050120.55859613
75Sulfur relay system_Homo sapiens_hsa041220.55718882
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54547623
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54187514
78Pancreatic cancer_Homo sapiens_hsa052120.52306258
79Folate biosynthesis_Homo sapiens_hsa007900.49619253
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49237752
81Chronic myeloid leukemia_Homo sapiens_hsa052200.49169557
82Fanconi anemia pathway_Homo sapiens_hsa034600.48803146
83Cell cycle_Homo sapiens_hsa041100.48758842
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48488451
85Rheumatoid arthritis_Homo sapiens_hsa053230.47647264
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47308195
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.47190307
88Small cell lung cancer_Homo sapiens_hsa052220.47076152
89Lysosome_Homo sapiens_hsa041420.46639568
90Systemic lupus erythematosus_Homo sapiens_hsa053220.44989817
91N-Glycan biosynthesis_Homo sapiens_hsa005100.44774053
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44718385
93Arachidonic acid metabolism_Homo sapiens_hsa005900.44522613
94Linoleic acid metabolism_Homo sapiens_hsa005910.43022742
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42709676
96Prolactin signaling pathway_Homo sapiens_hsa049170.39343267
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38553407
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35596247
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34811191
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34516131
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32631902
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32376380
103ABC transporters_Homo sapiens_hsa020100.31169941
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31023732
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30574466
106Regulation of autophagy_Homo sapiens_hsa041400.28100964
107Sulfur metabolism_Homo sapiens_hsa009200.26334179
108Purine metabolism_Homo sapiens_hsa002300.25511119
109Alzheimers disease_Homo sapiens_hsa050100.23882002
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23286402
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23044096
112Phagosome_Homo sapiens_hsa041450.21516665
113Endocytosis_Homo sapiens_hsa041440.21334602
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21235663
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16887957
116Peroxisome_Homo sapiens_hsa041460.14990809
117Chemical carcinogenesis_Homo sapiens_hsa052040.14782301
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.11955276
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11667337
120Collecting duct acid secretion_Homo sapiens_hsa049660.10450040
121Nitrogen metabolism_Homo sapiens_hsa009100.08117375
122Renin-angiotensin system_Homo sapiens_hsa046140.07790569
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07717717
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07630811
125Ether lipid metabolism_Homo sapiens_hsa005650.07549293
126Phototransduction_Homo sapiens_hsa047440.07517336
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.05745555
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.04032902
129Glycerolipid metabolism_Homo sapiens_hsa005610.03655797
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.02710425
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.02667110

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