

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.67970169 |
| 2 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 5.33222863 |
| 3 | cullin deneddylation (GO:0010388) | 5.03843331 |
| 4 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.98519171 |
| 5 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.97703954 |
| 6 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.97553083 |
| 7 | protein deneddylation (GO:0000338) | 4.85781356 |
| 8 | negative regulation of ligase activity (GO:0051352) | 4.81571212 |
| 9 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.81571212 |
| 10 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.73160967 |
| 11 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.70564432 |
| 12 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 4.64474255 |
| 13 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 4.64474255 |
| 14 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 4.64474255 |
| 15 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 4.62894328 |
| 16 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 4.62894328 |
| 17 | establishment of integrated proviral latency (GO:0075713) | 4.51352939 |
| 18 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 4.47715605 |
| 19 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 4.45075289 |
| 20 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 4.45075289 |
| 21 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 4.23373573 |
| 22 | positive regulation of ligase activity (GO:0051351) | 4.04419842 |
| 23 | DNA ligation (GO:0006266) | 4.00945888 |
| 24 | establishment of viral latency (GO:0019043) | 3.98375155 |
| 25 | ribosome assembly (GO:0042255) | 3.89713101 |
| 26 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.77820894 |
| 27 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.69095737 |
| 28 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.67974246 |
| 29 | regulation of ligase activity (GO:0051340) | 3.63829996 |
| 30 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.57120922 |
| 31 | regulation of cellular amine metabolic process (GO:0033238) | 3.54206607 |
| 32 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.52281877 |
| 33 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.47895053 |
| 34 | positive regulation of cell cycle arrest (GO:0071158) | 3.43686302 |
| 35 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.42777189 |
| 36 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.42777189 |
| 37 | DNA double-strand break processing (GO:0000729) | 3.42185547 |
| 38 | CENP-A containing nucleosome assembly (GO:0034080) | 3.39727642 |
| 39 | spliceosomal snRNP assembly (GO:0000387) | 3.39434307 |
| 40 | negative regulation of protein ubiquitination (GO:0031397) | 3.39295578 |
| 41 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.37860866 |
| 42 | chromatin remodeling at centromere (GO:0031055) | 3.35538621 |
| 43 | DNA deamination (GO:0045006) | 3.33342230 |
| 44 | histone H2A acetylation (GO:0043968) | 3.31723601 |
| 45 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.28832184 |
| 46 | respiratory chain complex IV assembly (GO:0008535) | 3.28541947 |
| 47 | protein K6-linked ubiquitination (GO:0085020) | 3.27264110 |
| 48 | negative regulation of protein modification by small protein conjugation or removal (GO:1903321) | 3.20835458 |
| 49 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.20696072 |
| 50 | mitotic metaphase plate congression (GO:0007080) | 3.17569769 |
| 51 | iron-sulfur cluster assembly (GO:0016226) | 3.17252313 |
| 52 | metallo-sulfur cluster assembly (GO:0031163) | 3.17252313 |
| 53 | protein neddylation (GO:0045116) | 3.12453585 |
| 54 | DNA damage response, detection of DNA damage (GO:0042769) | 3.12039020 |
| 55 | L-methionine salvage (GO:0071267) | 3.10683371 |
| 56 | L-methionine biosynthetic process (GO:0071265) | 3.10683371 |
| 57 | amino acid salvage (GO:0043102) | 3.10683371 |
| 58 | branched-chain amino acid catabolic process (GO:0009083) | 3.09458061 |
| 59 | protein complex biogenesis (GO:0070271) | 3.08495069 |
| 60 | signal transduction in response to DNA damage (GO:0042770) | 3.08407442 |
| 61 | chaperone-mediated protein transport (GO:0072321) | 3.07805185 |
| 62 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.07391956 |
| 63 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.07391956 |
| 64 | NADH dehydrogenase complex assembly (GO:0010257) | 3.07391956 |
| 65 | mannosylation (GO:0097502) | 3.06078970 |
| 66 | tRNA aminoacylation for protein translation (GO:0006418) | 3.04640310 |
| 67 | purine nucleobase biosynthetic process (GO:0009113) | 3.04178983 |
| 68 | ubiquinone biosynthetic process (GO:0006744) | 3.01842204 |
| 69 | negative regulation of G1/S transition of mitotic cell cycle (GO:2000134) | 3.01670553 |
| 70 | negative regulation of cell cycle G1/S phase transition (GO:1902807) | 3.01670553 |
| 71 | termination of RNA polymerase III transcription (GO:0006386) | 3.00267870 |
| 72 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.00267870 |
| 73 | metaphase plate congression (GO:0051310) | 2.99983012 |
| 74 | protein targeting to mitochondrion (GO:0006626) | 2.99175480 |
| 75 | ubiquinone metabolic process (GO:0006743) | 2.98820173 |
| 76 | maturation of 5.8S rRNA (GO:0000460) | 2.98489737 |
| 77 | cell cycle G1/S phase transition (GO:0044843) | 2.97967197 |
| 78 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.97967197 |
| 79 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.97766300 |
| 80 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.96984100 |
| 81 | tRNA aminoacylation (GO:0043039) | 2.96717330 |
| 82 | amino acid activation (GO:0043038) | 2.96717330 |
| 83 | double-strand break repair via nonhomologous end joining (GO:0006303) | 2.96185215 |
| 84 | non-recombinational repair (GO:0000726) | 2.96185215 |
| 85 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.94921946 |
| 86 | DNA strand elongation involved in DNA replication (GO:0006271) | 2.94435409 |
| 87 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.93505212 |
| 88 | rRNA modification (GO:0000154) | 2.92871971 |
| 89 | peptidyl-histidine modification (GO:0018202) | 2.92317672 |
| 90 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.91817272 |
| 91 | ATP synthesis coupled proton transport (GO:0015986) | 2.91817272 |
| 92 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.86611269 |
| 93 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.86611269 |
| 94 | protein localization to mitochondrion (GO:0070585) | 2.86278514 |
| 95 | regulation of cell cycle arrest (GO:0071156) | 2.84750825 |
| 96 | DNA strand elongation (GO:0022616) | 2.84115606 |
| 97 | peptidyl-arginine omega-N-methylation (GO:0035247) | 2.83723465 |
| 98 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.83368912 |
| 99 | histone mRNA metabolic process (GO:0008334) | 2.82807446 |
| 100 | tricarboxylic acid cycle (GO:0006099) | 2.82563383 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.48688716 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.57402314 |
| 3 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 4.42538452 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.94289329 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.73502493 |
| 6 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.43196095 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.14602716 |
| 8 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.13541912 |
| 9 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.11372666 |
| 10 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.05389861 |
| 11 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.03969301 |
| 12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.00024859 |
| 13 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.98945004 |
| 14 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.96213750 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.81388144 |
| 16 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.76412563 |
| 17 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.52272908 |
| 18 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.51220241 |
| 19 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.49355082 |
| 20 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.44274145 |
| 21 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.43693154 |
| 22 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.41511137 |
| 23 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.32079404 |
| 24 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.23650185 |
| 25 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.20424057 |
| 26 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.19876827 |
| 27 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 2.19113921 |
| 28 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.17704553 |
| 29 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.16776205 |
| 30 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.16534437 |
| 31 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.12074758 |
| 32 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.10164765 |
| 33 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.06623379 |
| 34 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.03000988 |
| 35 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.01966389 |
| 36 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.00775838 |
| 37 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.95486694 |
| 38 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.83220036 |
| 39 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.73055162 |
| 40 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.72732703 |
| 41 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.68242203 |
| 42 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.62058278 |
| 43 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.61400584 |
| 44 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.56954954 |
| 45 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.54605598 |
| 46 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.52286528 |
| 47 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.50250987 |
| 48 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.41499352 |
| 49 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.40904715 |
| 50 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.29789961 |
| 51 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.29072448 |
| 52 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.29062263 |
| 53 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.28050422 |
| 54 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.27423982 |
| 55 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.25711866 |
| 56 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.25576064 |
| 57 | EWS_26573619_Chip-Seq_HEK293_Human | 1.24949025 |
| 58 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.21949310 |
| 59 | VDR_22108803_ChIP-Seq_LS180_Human | 1.18307092 |
| 60 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.18075988 |
| 61 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.18022899 |
| 62 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.16420931 |
| 63 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.15960300 |
| 64 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.15703437 |
| 65 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.15227497 |
| 66 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.13859696 |
| 67 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.12739370 |
| 68 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.12136377 |
| 69 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.11771049 |
| 70 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.11416208 |
| 71 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.10936565 |
| 72 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.10211292 |
| 73 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.08139687 |
| 74 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.08118946 |
| 75 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.07641813 |
| 76 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.07593330 |
| 77 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.02048008 |
| 78 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.01336063 |
| 79 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.01084485 |
| 80 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.00321165 |
| 81 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.98751096 |
| 82 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.95466702 |
| 83 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.90515639 |
| 84 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.88368131 |
| 85 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.88211792 |
| 86 | FUS_26573619_Chip-Seq_HEK293_Human | 0.87620347 |
| 87 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.86165467 |
| 88 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.85905675 |
| 89 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.84750276 |
| 90 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.84419440 |
| 91 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.82739053 |
| 92 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.82491096 |
| 93 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.80708508 |
| 94 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.80623478 |
| 95 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.80043166 |
| 96 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.79919360 |
| 97 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.78932378 |
| 98 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.77102532 |
| 99 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.76757383 |
| 100 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.74248506 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008058_abnormal_DNA_repair | 4.16232786 |
| 2 | MP0002102_abnormal_ear_morphology | 3.95371116 |
| 3 | MP0010094_abnormal_chromosome_stability | 3.89151150 |
| 4 | MP0003693_abnormal_embryo_hatching | 3.76434709 |
| 5 | MP0000372_irregular_coat_pigmentation | 3.15925228 |
| 6 | MP0004957_abnormal_blastocyst_morpholog | 2.95985645 |
| 7 | MP0003806_abnormal_nucleotide_metabolis | 2.73158365 |
| 8 | MP0003111_abnormal_nucleus_morphology | 2.67789466 |
| 9 | MP0008932_abnormal_embryonic_tissue | 2.67604133 |
| 10 | MP0009697_abnormal_copulation | 2.60871645 |
| 11 | MP0003786_premature_aging | 2.58001643 |
| 12 | MP0005075_abnormal_melanosome_morpholog | 2.52438475 |
| 13 | MP0008007_abnormal_cellular_replicative | 2.50861664 |
| 14 | MP0001529_abnormal_vocalization | 2.47780777 |
| 15 | MP0003077_abnormal_cell_cycle | 2.42801778 |
| 16 | MP0006035_abnormal_mitochondrial_morpho | 2.39703518 |
| 17 | MP0006036_abnormal_mitochondrial_physio | 2.32882802 |
| 18 | MP0000749_muscle_degeneration | 2.29027399 |
| 19 | MP0008789_abnormal_olfactory_epithelium | 2.26556754 |
| 20 | MP0006072_abnormal_retinal_apoptosis | 2.23571218 |
| 21 | MP0003718_maternal_effect | 2.14992362 |
| 22 | MP0008877_abnormal_DNA_methylation | 1.97576121 |
| 23 | MP0003221_abnormal_cardiomyocyte_apopto | 1.88562172 |
| 24 | MP0000751_myopathy | 1.71974729 |
| 25 | MP0004147_increased_porphyrin_level | 1.68371077 |
| 26 | MP0003011_delayed_dark_adaptation | 1.63268870 |
| 27 | MP0005253_abnormal_eye_physiology | 1.62011922 |
| 28 | MP0003186_abnormal_redox_activity | 1.55635938 |
| 29 | MP0005499_abnormal_olfactory_system | 1.50941056 |
| 30 | MP0005394_taste/olfaction_phenotype | 1.50941056 |
| 31 | MP0000358_abnormal_cell_content/ | 1.50472985 |
| 32 | MP0002751_abnormal_autonomic_nervous | 1.47049900 |
| 33 | MP0005084_abnormal_gallbladder_morpholo | 1.46431081 |
| 34 | MP0001764_abnormal_homeostasis | 1.39124820 |
| 35 | MP0008995_early_reproductive_senescence | 1.38614418 |
| 36 | MP0001727_abnormal_embryo_implantation | 1.35001201 |
| 37 | MP0004145_abnormal_muscle_electrophysio | 1.33923142 |
| 38 | MP0002938_white_spotting | 1.28895653 |
| 39 | MP0003567_abnormal_fetal_cardiomyocyte | 1.24058228 |
| 40 | MP0006276_abnormal_autonomic_nervous | 1.19741604 |
| 41 | MP0000647_abnormal_sebaceous_gland | 1.19379263 |
| 42 | MP0001730_embryonic_growth_arrest | 1.16880742 |
| 43 | MP0004215_abnormal_myocardial_fiber | 1.16753302 |
| 44 | MP0005645_abnormal_hypothalamus_physiol | 1.14524624 |
| 45 | MP0006054_spinal_hemorrhage | 1.09516062 |
| 46 | MP0008260_abnormal_autophagy | 1.08507046 |
| 47 | MP0002269_muscular_atrophy | 1.08048309 |
| 48 | MP0005330_cardiomyopathy | 1.07688356 |
| 49 | MP0002254_reproductive_system_inflammat | 1.07360590 |
| 50 | MP0001984_abnormal_olfaction | 1.04300189 |
| 51 | MP0003646_muscle_fatigue | 1.03859037 |
| 52 | MP0002234_abnormal_pharynx_morphology | 1.01791261 |
| 53 | MP0000516_abnormal_urinary_system | 1.01679286 |
| 54 | MP0005367_renal/urinary_system_phenotyp | 1.01679286 |
| 55 | MP0002090_abnormal_vision | 1.01391454 |
| 56 | MP0001293_anophthalmia | 1.00191994 |
| 57 | MP0003195_calcinosis | 0.99649598 |
| 58 | MP0002736_abnormal_nociception_after | 0.98199453 |
| 59 | MP0005171_absent_coat_pigmentation | 0.96955288 |
| 60 | MP0003137_abnormal_impulse_conducting | 0.94136715 |
| 61 | MP0001905_abnormal_dopamine_level | 0.92580696 |
| 62 | MP0002282_abnormal_trachea_morphology | 0.90465858 |
| 63 | MP0003121_genomic_imprinting | 0.89038331 |
| 64 | MP0001243_abnormal_dermal_layer | 0.85652550 |
| 65 | MP0001929_abnormal_gametogenesis | 0.84938015 |
| 66 | MP0001697_abnormal_embryo_size | 0.83815514 |
| 67 | MP0002080_prenatal_lethality | 0.82955311 |
| 68 | MP0004084_abnormal_cardiac_muscle | 0.82740603 |
| 69 | MP0002332_abnormal_exercise_endurance | 0.81013696 |
| 70 | MP0002019_abnormal_tumor_incidence | 0.79026911 |
| 71 | MP0002210_abnormal_sex_determination | 0.78214062 |
| 72 | MP0002233_abnormal_nose_morphology | 0.77902507 |
| 73 | MP0008872_abnormal_physiological_respon | 0.77876134 |
| 74 | MP0004133_heterotaxia | 0.77635613 |
| 75 | MP0006292_abnormal_olfactory_placode | 0.75820538 |
| 76 | MP0005266_abnormal_metabolism | 0.75452509 |
| 77 | MP0003950_abnormal_plasma_membrane | 0.73910932 |
| 78 | MP0000653_abnormal_sex_gland | 0.72753005 |
| 79 | MP0004197_abnormal_fetal_growth/weight/ | 0.72380910 |
| 80 | MP0000747_muscle_weakness | 0.72269584 |
| 81 | MP0000049_abnormal_middle_ear | 0.72041366 |
| 82 | MP0000350_abnormal_cell_proliferation | 0.71912696 |
| 83 | MP0001145_abnormal_male_reproductive | 0.69651292 |
| 84 | MP0001119_abnormal_female_reproductive | 0.69585884 |
| 85 | MP0003937_abnormal_limbs/digits/tail_de | 0.68470609 |
| 86 | MP0005408_hypopigmentation | 0.68040558 |
| 87 | MP0002837_dystrophic_cardiac_calcinosis | 0.67059450 |
| 88 | MP0005391_vision/eye_phenotype | 0.65311355 |
| 89 | MP0008873_increased_physiological_sensi | 0.65012128 |
| 90 | MP0000313_abnormal_cell_death | 0.64534248 |
| 91 | MP0002106_abnormal_muscle_physiology | 0.64512411 |
| 92 | MP0001672_abnormal_embryogenesis/_devel | 0.64488016 |
| 93 | MP0005380_embryogenesis_phenotype | 0.64488016 |
| 94 | MP0003880_abnormal_central_pattern | 0.63824475 |
| 95 | MP0008057_abnormal_DNA_replication | 0.63719468 |
| 96 | MP0005551_abnormal_eye_electrophysiolog | 0.60822963 |
| 97 | MP0002177_abnormal_outer_ear | 0.60678429 |
| 98 | MP0002972_abnormal_cardiac_muscle | 0.58107404 |
| 99 | MP0001324_abnormal_eye_pigmentation | 0.57924837 |
| 100 | MP0000013_abnormal_adipose_tissue | 0.56858191 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.15491654 |
| 2 | Hepatocellular necrosis (HP:0001404) | 4.05538413 |
| 3 | Acute encephalopathy (HP:0006846) | 3.97647932 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.97381779 |
| 5 | Increased serum pyruvate (HP:0003542) | 3.84709670 |
| 6 | Mitochondrial inheritance (HP:0001427) | 3.84201281 |
| 7 | Increased CSF lactate (HP:0002490) | 3.81398867 |
| 8 | Abnormality of glycolysis (HP:0004366) | 3.77068658 |
| 9 | Hepatic necrosis (HP:0002605) | 3.71097682 |
| 10 | Progressive macrocephaly (HP:0004481) | 3.33742406 |
| 11 | Abnormality of the anterior horn cell (HP:0006802) | 3.14866932 |
| 12 | Degeneration of anterior horn cells (HP:0002398) | 3.14866932 |
| 13 | Type I transferrin isoform profile (HP:0003642) | 3.12153511 |
| 14 | Increased serum lactate (HP:0002151) | 3.10810784 |
| 15 | Cerebral edema (HP:0002181) | 3.06555395 |
| 16 | Lactic acidosis (HP:0003128) | 2.96313648 |
| 17 | Increased hepatocellular lipid droplets (HP:0006565) | 2.94366192 |
| 18 | Abnormal protein glycosylation (HP:0012346) | 2.92486096 |
| 19 | Abnormal glycosylation (HP:0012345) | 2.92486096 |
| 20 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.92486096 |
| 21 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.92486096 |
| 22 | Lipid accumulation in hepatocytes (HP:0006561) | 2.89499639 |
| 23 | Microvesicular hepatic steatosis (HP:0001414) | 2.89266847 |
| 24 | Exercise-induced muscle cramps (HP:0003710) | 2.84628521 |
| 25 | Type 2 muscle fiber atrophy (HP:0003554) | 2.78570515 |
| 26 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.76070575 |
| 27 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.76070575 |
| 28 | Exercise intolerance (HP:0003546) | 2.70048093 |
| 29 | Abnormality of the labia minora (HP:0012880) | 2.66816860 |
| 30 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.62085857 |
| 31 | True hermaphroditism (HP:0010459) | 2.57764153 |
| 32 | Pancreatic cysts (HP:0001737) | 2.57236760 |
| 33 | Hyperglycinemia (HP:0002154) | 2.56101592 |
| 34 | Increased intramyocellular lipid droplets (HP:0012240) | 2.56005552 |
| 35 | Short tibia (HP:0005736) | 2.53223426 |
| 36 | Medial flaring of the eyebrow (HP:0010747) | 2.48880349 |
| 37 | Muscle fiber atrophy (HP:0100295) | 2.46607294 |
| 38 | Nemaline bodies (HP:0003798) | 2.46346782 |
| 39 | Reduced antithrombin III activity (HP:0001976) | 2.45588999 |
| 40 | Respiratory failure (HP:0002878) | 2.44564878 |
| 41 | Pancreatic fibrosis (HP:0100732) | 2.44429982 |
| 42 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.42010800 |
| 43 | Abnormality of alanine metabolism (HP:0010916) | 2.42010800 |
| 44 | Hyperalaninemia (HP:0003348) | 2.42010800 |
| 45 | Abnormality of placental membranes (HP:0011409) | 2.37984196 |
| 46 | Amniotic constriction ring (HP:0009775) | 2.37984196 |
| 47 | Methylmalonic acidemia (HP:0002912) | 2.35251211 |
| 48 | 3-Methylglutaconic aciduria (HP:0003535) | 2.26897016 |
| 49 | Abnormality of serum amino acid levels (HP:0003112) | 2.26684537 |
| 50 | CNS demyelination (HP:0007305) | 2.25316201 |
| 51 | Postnatal microcephaly (HP:0005484) | 2.20938874 |
| 52 | Abnormality of glycine metabolism (HP:0010895) | 2.20675751 |
| 53 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.20675751 |
| 54 | Methylmalonic aciduria (HP:0012120) | 2.17896122 |
| 55 | Lethargy (HP:0001254) | 2.17886499 |
| 56 | Multiple enchondromatosis (HP:0005701) | 2.16776966 |
| 57 | Increased muscle lipid content (HP:0009058) | 2.16748915 |
| 58 | Abnormality of midbrain morphology (HP:0002418) | 2.14838224 |
| 59 | Molar tooth sign on MRI (HP:0002419) | 2.14838224 |
| 60 | Emotional lability (HP:0000712) | 2.14813211 |
| 61 | Congenital primary aphakia (HP:0007707) | 2.14492499 |
| 62 | Meckel diverticulum (HP:0002245) | 2.13708481 |
| 63 | Cerebral hypomyelination (HP:0006808) | 2.13065069 |
| 64 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.09968209 |
| 65 | Abnormal gallbladder physiology (HP:0012438) | 2.08772127 |
| 66 | Cholecystitis (HP:0001082) | 2.08772127 |
| 67 | Renal Fanconi syndrome (HP:0001994) | 2.07729039 |
| 68 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 2.06650313 |
| 69 | Nephrogenic diabetes insipidus (HP:0009806) | 2.05911952 |
| 70 | Abnormality of the ileum (HP:0001549) | 2.05093986 |
| 71 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.02525667 |
| 72 | Hyperglycinuria (HP:0003108) | 2.01229507 |
| 73 | Optic disc pallor (HP:0000543) | 1.97838626 |
| 74 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.97504089 |
| 75 | Muscle fiber inclusion bodies (HP:0100299) | 1.97157827 |
| 76 | Gait imbalance (HP:0002141) | 1.95661670 |
| 77 | Retinal dysplasia (HP:0007973) | 1.92845830 |
| 78 | Neoplasm of the adrenal gland (HP:0100631) | 1.92245671 |
| 79 | Abnormality of the preputium (HP:0100587) | 1.92196298 |
| 80 | Dicarboxylic aciduria (HP:0003215) | 1.90902650 |
| 81 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.90902650 |
| 82 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.90901304 |
| 83 | Colon cancer (HP:0003003) | 1.90642796 |
| 84 | Neonatal respiratory distress (HP:0002643) | 1.89438096 |
| 85 | Abnormal lung lobation (HP:0002101) | 1.89166150 |
| 86 | Shoulder girdle muscle weakness (HP:0003547) | 1.88613558 |
| 87 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.87237937 |
| 88 | Limb-girdle muscle atrophy (HP:0003797) | 1.87133379 |
| 89 | Bifid tongue (HP:0010297) | 1.85776595 |
| 90 | Progressive inability to walk (HP:0002505) | 1.84764894 |
| 91 | Rhabdomyolysis (HP:0003201) | 1.82505826 |
| 92 | Sclerocornea (HP:0000647) | 1.81541129 |
| 93 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.80639302 |
| 94 | Generalized aminoaciduria (HP:0002909) | 1.80580654 |
| 95 | Autoamputation (HP:0001218) | 1.80066089 |
| 96 | Aplastic anemia (HP:0001915) | 1.79222450 |
| 97 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.78056890 |
| 98 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.78056890 |
| 99 | Prominent metopic ridge (HP:0005487) | 1.77179315 |
| 100 | Pancytopenia (HP:0001876) | 1.76741454 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRIM28 | 4.00744135 |
| 2 | BUB1 | 3.74154478 |
| 3 | SRPK1 | 3.20098329 |
| 4 | VRK2 | 3.14998420 |
| 5 | MAP4K2 | 2.64166992 |
| 6 | BCR | 2.49144235 |
| 7 | NEK1 | 2.47260795 |
| 8 | EIF2AK1 | 2.41676769 |
| 9 | TSSK6 | 2.40786901 |
| 10 | EIF2AK3 | 2.34892673 |
| 11 | BCKDK | 2.22338846 |
| 12 | STK16 | 2.20794741 |
| 13 | MST4 | 2.10496340 |
| 14 | ERBB3 | 2.07817696 |
| 15 | LIMK1 | 2.00189362 |
| 16 | TESK2 | 1.92299999 |
| 17 | PLK3 | 1.90456998 |
| 18 | SIK3 | 1.85500027 |
| 19 | ZAK | 1.79132539 |
| 20 | NUAK1 | 1.75892568 |
| 21 | CCNB1 | 1.75839648 |
| 22 | PBK | 1.71516953 |
| 23 | WNK3 | 1.70137559 |
| 24 | CSNK1G3 | 1.66596523 |
| 25 | VRK1 | 1.65408083 |
| 26 | BMPR1B | 1.62065057 |
| 27 | KDR | 1.61281555 |
| 28 | TESK1 | 1.57197887 |
| 29 | MAP3K12 | 1.56548673 |
| 30 | TTK | 1.48968109 |
| 31 | RPS6KA4 | 1.45202291 |
| 32 | CDC7 | 1.41152305 |
| 33 | PDK2 | 1.34325799 |
| 34 | CSNK1A1L | 1.33824385 |
| 35 | CSNK1G2 | 1.30726459 |
| 36 | CSNK1G1 | 1.30232267 |
| 37 | DAPK1 | 1.26889143 |
| 38 | MAP2K7 | 1.24994085 |
| 39 | MKNK1 | 1.24486029 |
| 40 | PLK1 | 1.14539464 |
| 41 | PLK4 | 1.11344421 |
| 42 | WEE1 | 1.07952411 |
| 43 | PLK2 | 1.07255176 |
| 44 | MAPKAPK3 | 1.05986958 |
| 45 | NME1 | 0.98944854 |
| 46 | BRSK2 | 0.98029824 |
| 47 | PAK4 | 0.96510358 |
| 48 | MKNK2 | 0.96024241 |
| 49 | OBSCN | 0.93716289 |
| 50 | CDK8 | 0.91508352 |
| 51 | CDK19 | 0.91308589 |
| 52 | DYRK2 | 0.86086554 |
| 53 | EIF2AK2 | 0.80995491 |
| 54 | AURKB | 0.78999812 |
| 55 | ATR | 0.78691171 |
| 56 | SCYL2 | 0.76404403 |
| 57 | BRSK1 | 0.73497048 |
| 58 | MAP3K4 | 0.72040043 |
| 59 | STK38L | 0.70138149 |
| 60 | TIE1 | 0.65629877 |
| 61 | MINK1 | 0.62836159 |
| 62 | PINK1 | 0.61801512 |
| 63 | FER | 0.59302428 |
| 64 | STK10 | 0.59183695 |
| 65 | MAP3K5 | 0.57789800 |
| 66 | GRK1 | 0.56482105 |
| 67 | MAPK13 | 0.56307932 |
| 68 | MUSK | 0.55705391 |
| 69 | DYRK3 | 0.55343705 |
| 70 | PIM2 | 0.52953112 |
| 71 | MYLK | 0.51777438 |
| 72 | RPS6KA5 | 0.50710827 |
| 73 | FLT3 | 0.50321188 |
| 74 | CSNK2A1 | 0.49960008 |
| 75 | AURKA | 0.49374027 |
| 76 | TAF1 | 0.48860477 |
| 77 | CDK7 | 0.46306406 |
| 78 | ADRBK2 | 0.43954940 |
| 79 | NME2 | 0.43549839 |
| 80 | CDK9 | 0.43158960 |
| 81 | CHEK2 | 0.40741230 |
| 82 | ATM | 0.39951535 |
| 83 | ERBB4 | 0.39662641 |
| 84 | TAOK3 | 0.38962742 |
| 85 | INSRR | 0.36478743 |
| 86 | CDK14 | 0.36406913 |
| 87 | PRKCE | 0.34269988 |
| 88 | EPHA2 | 0.33052961 |
| 89 | PHKG2 | 0.32514636 |
| 90 | PHKG1 | 0.32514636 |
| 91 | CSNK2A2 | 0.31912241 |
| 92 | CSNK1A1 | 0.31856975 |
| 93 | CHEK1 | 0.30132280 |
| 94 | CDK18 | 0.29242505 |
| 95 | PAK1 | 0.29237974 |
| 96 | EPHA3 | 0.28795311 |
| 97 | PRKCI | 0.23559676 |
| 98 | MST1R | 0.21812331 |
| 99 | OXSR1 | 0.20784174 |
| 100 | ALK | 0.18139615 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.70813713 |
| 2 | Protein export_Homo sapiens_hsa03060 | 2.82506522 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 2.69929601 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 2.55238824 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.46951897 |
| 6 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.38108635 |
| 7 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.33699176 |
| 8 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.32161305 |
| 9 | RNA polymerase_Homo sapiens_hsa03020 | 2.32043771 |
| 10 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.28836760 |
| 11 | Parkinsons disease_Homo sapiens_hsa05012 | 2.26064008 |
| 12 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.19369122 |
| 13 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.14175794 |
| 14 | Base excision repair_Homo sapiens_hsa03410 | 2.12703740 |
| 15 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.11231828 |
| 16 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.09385763 |
| 17 | Spliceosome_Homo sapiens_hsa03040 | 2.01986287 |
| 18 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.98042792 |
| 19 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.96831020 |
| 20 | RNA transport_Homo sapiens_hsa03013 | 1.84843720 |
| 21 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.81473073 |
| 22 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.79669363 |
| 23 | Homologous recombination_Homo sapiens_hsa03440 | 1.77378280 |
| 24 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.77187019 |
| 25 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.65840843 |
| 26 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.64626949 |
| 27 | RNA degradation_Homo sapiens_hsa03018 | 1.59940507 |
| 28 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.59728932 |
| 29 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.57587726 |
| 30 | Basal transcription factors_Homo sapiens_hsa03022 | 1.56612993 |
| 31 | Carbon metabolism_Homo sapiens_hsa01200 | 1.54864383 |
| 32 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.52047500 |
| 33 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.49403501 |
| 34 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.46844644 |
| 35 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.45477694 |
| 36 | Huntingtons disease_Homo sapiens_hsa05016 | 1.44577684 |
| 37 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.38156647 |
| 38 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.37488084 |
| 39 | Purine metabolism_Homo sapiens_hsa00230 | 1.17671003 |
| 40 | Alzheimers disease_Homo sapiens_hsa05010 | 1.16689907 |
| 41 | Cell cycle_Homo sapiens_hsa04110 | 1.12058078 |
| 42 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.09967451 |
| 43 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.08442027 |
| 44 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.07500117 |
| 45 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.06859881 |
| 46 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.05054336 |
| 47 | Peroxisome_Homo sapiens_hsa04146 | 1.01299001 |
| 48 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.95425205 |
| 49 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.87459708 |
| 50 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.86057894 |
| 51 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.82285684 |
| 52 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.79986997 |
| 53 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.77049539 |
| 54 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.75886616 |
| 55 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.74793502 |
| 56 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.73589795 |
| 57 | Metabolic pathways_Homo sapiens_hsa01100 | 0.73010662 |
| 58 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.71469431 |
| 59 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.70698699 |
| 60 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.67775992 |
| 61 | Sulfur relay system_Homo sapiens_hsa04122 | 0.65006616 |
| 62 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.62891431 |
| 63 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.60384543 |
| 64 | Phototransduction_Homo sapiens_hsa04744 | 0.60126538 |
| 65 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.58908383 |
| 66 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.58307147 |
| 67 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.57208646 |
| 68 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.56746666 |
| 69 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.55386172 |
| 70 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.53577689 |
| 71 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.53473349 |
| 72 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.50920958 |
| 73 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.48409978 |
| 74 | Shigellosis_Homo sapiens_hsa05131 | 0.48078270 |
| 75 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.46250437 |
| 76 | Legionellosis_Homo sapiens_hsa05134 | 0.46055667 |
| 77 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.43303913 |
| 78 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.39731168 |
| 79 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.36347737 |
| 80 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.35267757 |
| 81 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.34882794 |
| 82 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.34620865 |
| 83 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.33070616 |
| 84 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.29503350 |
| 85 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.25958202 |
| 86 | Galactose metabolism_Homo sapiens_hsa00052 | 0.25694029 |
| 87 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.25210535 |
| 88 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.21638695 |
| 89 | Viral myocarditis_Homo sapiens_hsa05416 | 0.20367649 |
| 90 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.18699315 |
| 91 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.18588280 |
| 92 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.16560834 |
| 93 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.16090952 |
| 94 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.15101993 |
| 95 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.10979191 |
| 96 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.10770203 |
| 97 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.10655368 |
| 98 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.10493242 |
| 99 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.08194089 |
| 100 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.07730728 |

