ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein K6-linked ubiquitination (GO:0085020)	6.33218192
2	DNA deamination (GO:0045006)	5.25632732
3	behavioral response to nicotine (GO:0035095)	4.89515299
4	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.41220494
5	UDP-N-acetylglucosamine metabolic process (GO:0006047)	4.37587503
6	platelet dense granule organization (GO:0060155)	4.08829674
7	mannosylation (GO:0097502)	4.04420216
8	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.99355840
9	cytidine metabolic process (GO:0046087)	3.96723976
10	cytidine catabolic process (GO:0006216)	3.96723976
11	cytidine deamination (GO:0009972)	3.96723976
12	chaperone-mediated protein transport (GO:0072321)	3.84464427
13	regulation of centriole replication (GO:0046599)	3.70590347
14	protein neddylation (GO:0045116)	3.61547142
15	termination of RNA polymerase III transcription (GO:0006386)	3.49549059
16	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.49549059
17	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.47397279
18	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.47397279
19	negative regulation of heart rate (GO:0010459)	3.42168363
20	negative regulation of mast cell activation (GO:0033004)	3.30302336
21	sulfation (GO:0051923)	3.29843255
22	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	3.26447770
23	cellular response to ATP (GO:0071318)	3.25482021
24	negative regulation of glycogen biosynthetic process (GO:0045719)	3.20219986
25	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.19832437
26	ATP synthesis coupled proton transport (GO:0015986)	3.19832437
27	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.18787668
28	regulation of histone H3-K9 methylation (GO:0051570)	3.18582010
29	melanosome transport (GO:0032402)	3.15428709
30	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.08877444
31	endoderm formation (GO:0001706)	3.00583430
32	zinc ion homeostasis (GO:0055069)	2.98837295
33	regulation of regulatory T cell differentiation (GO:0045589)	2.98761213
34	pigment granule transport (GO:0051904)	2.98342303
35	protein polyglutamylation (GO:0018095)	2.98318732
36	establishment of melanosome localization (GO:0032401)	2.95663817
37	GPI anchor metabolic process (GO:0006505)	2.94612025
38	positive regulation of histone H3-K4 methylation (GO:0051571)	2.93554428
39	negative regulation of organelle assembly (GO:1902116)	2.91499784
40	iron-sulfur cluster assembly (GO:0016226)	2.90547793
41	metallo-sulfur cluster assembly (GO:0031163)	2.90547793
42	melanosome localization (GO:0032400)	2.89019291
43	lactate metabolic process (GO:0006089)	2.85789335
44	positive regulation of gastrulation (GO:2000543)	2.84208858
45	regulation of cholesterol esterification (GO:0010872)	2.80628525
46	drug catabolic process (GO:0042737)	2.80280993
47	establishment of pigment granule localization (GO:0051905)	2.80179642
48	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.75666767
49	electron transport chain (GO:0022900)	2.75373990
50	pigment granule localization (GO:0051875)	2.75039631
51	copper ion homeostasis (GO:0055070)	2.74919494
52	resolution of meiotic recombination intermediates (GO:0000712)	2.74665139
53	protein complex biogenesis (GO:0070271)	2.74616322
54	negative regulation of membrane potential (GO:0045837)	2.73007119
55	mast cell degranulation (GO:0043303)	2.72977094
56	mast cell activation involved in immune response (GO:0002279)	2.72977094
57	replication fork processing (GO:0031297)	2.72859791
58	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.70821321
59	anterograde synaptic vesicle transport (GO:0048490)	2.70245590
60	centriole replication (GO:0007099)	2.70164148
61	protein deneddylation (GO:0000338)	2.68776793
62	respiratory electron transport chain (GO:0022904)	2.67161782
63	regulation of cellular amino acid metabolic process (GO:0006521)	2.65815394
64	actin nucleation (GO:0045010)	2.65366754
65	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.62486573
66	S-adenosylmethionine metabolic process (GO:0046500)	2.60574473
67	cellular zinc ion homeostasis (GO:0006882)	2.60425691
68	sequestering of metal ion (GO:0051238)	2.56514527
69	proteasome assembly (GO:0043248)	2.55873318
70	response to pheromone (GO:0019236)	2.55095529
71	hydrogen ion transmembrane transport (GO:1902600)	2.54936859
72	water-soluble vitamin biosynthetic process (GO:0042364)	2.52596992
73	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.52420458
74	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.52019969
75	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.52019969
76	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.51580347
77	GPI anchor biosynthetic process (GO:0006506)	2.50382432
78	proton transport (GO:0015992)	2.49763664
79	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.48548915
80	hydrogen transport (GO:0006818)	2.48430643
81	dopamine transport (GO:0015872)	2.48330307
82	postreplication repair (GO:0006301)	2.48175972
83	multicellular organism reproduction (GO:0032504)	2.47855681
84	peroxisome fission (GO:0016559)	2.47419350
85	dicarboxylic acid catabolic process (GO:0043649)	2.46967533
86	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.46626031
87	piRNA metabolic process (GO:0034587)	2.46515470
88	T-helper cell differentiation (GO:0042093)	2.44149717
89	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	2.44149717
90	negative regulation of glycogen metabolic process (GO:0070874)	2.42092431
91	adaptation of signaling pathway (GO:0023058)	2.41608822
92	NADH dehydrogenase complex assembly (GO:0010257)	2.41298271
93	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.41298271
94	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.41298271
95	lens fiber cell differentiation (GO:0070306)	2.40776235
96	regulation of glucokinase activity (GO:0033131)	2.40648056
97	regulation of hexokinase activity (GO:1903299)	2.40648056
98	copper ion transport (GO:0006825)	2.40075760
99	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.40062011
100	cullin deneddylation (GO:0010388)	2.38273384

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.45813301
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.10768283
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.71419283
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.44620250
5	VDR_22108803_ChIP-Seq_LS180_Human	3.13778690
6	IRF1_19129219_ChIP-ChIP_H3396_Human	2.91412211
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.77075674
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.67773030
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.55136382
10	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.24547594
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.20662656
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.20550756
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.19823145
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.13240876
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.06193600
16	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.04874586
17	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.83991387
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.72064389
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.69819596
20	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.69477969
21	TP53_22573176_ChIP-Seq_HFKS_Human	1.68342868
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.67360250
23	P300_19829295_ChIP-Seq_ESCs_Human	1.62638263
24	HTT_18923047_ChIP-ChIP_STHdh_Human	1.60786163
25	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.60247324
26	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.60247324
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57081979
28	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57058705
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.55650038
30	VDR_23849224_ChIP-Seq_CD4+_Human	1.53943152
31	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.53221892
32	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.52846988
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.52705538
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.52664341
35	EWS_26573619_Chip-Seq_HEK293_Human	1.50381116
36	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.50342043
37	NANOG_19829295_ChIP-Seq_ESCs_Human	1.50158172
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.50158172
39	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.50088095
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43726936
41	AR_20517297_ChIP-Seq_VCAP_Human	1.42988723
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41741827
43	FOXP3_21729870_ChIP-Seq_TREG_Human	1.34593904
44	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.32989524
45	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.31723668
46	FUS_26573619_Chip-Seq_HEK293_Human	1.31616090
47	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.31046576
48	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.29953541
49	ER_23166858_ChIP-Seq_MCF-7_Human	1.28203670
50	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.27552130
51	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.26551749
52	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.26088047
53	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.22729589
54	CBP_20019798_ChIP-Seq_JUKART_Human	1.22002919
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.22002919
56	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.21532562
57	HOXB7_26014856_ChIP-Seq_BT474_Human	1.17659359
58	NCOR_22424771_ChIP-Seq_293T_Human	1.16648861
59	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.15417539
60	TAF2_19829295_ChIP-Seq_ESCs_Human	1.15266217
61	AR_25329375_ChIP-Seq_VCAP_Human	1.15130597
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14317433
63	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.13453023
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12668769
65	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12412680
66	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.12049053
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11277212
68	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.10810343
69	MYC_19829295_ChIP-Seq_ESCs_Human	1.10614164
70	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.09647582
71	BCAT_22108803_ChIP-Seq_LS180_Human	1.09374239
72	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.08570086
73	CDX2_22108803_ChIP-Seq_LS180_Human	1.08140678
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07235730
75	TCF4_23295773_ChIP-Seq_U87_Human	1.07196045
76	GATA3_26560356_Chip-Seq_TH2_Human	1.03966383
77	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.03736061
78	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.02552924
79	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.02406645
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01860562
81	ERA_21632823_ChIP-Seq_H3396_Human	1.01609465
82	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.01283564
83	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.99993797
84	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99016601
85	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.97636861
86	NANOG_20526341_ChIP-Seq_ESCs_Human	0.97441874
87	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.96434733
88	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.96248821
89	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.95883144
90	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.95175540
91	GATA3_26560356_Chip-Seq_TH1_Human	0.92795209
92	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.92719430
93	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.92567205
94	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.92247823
95	RUNX2_22187159_ChIP-Seq_PCA_Human	0.91877543
96	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.91501963
97	TCF4_22108803_ChIP-Seq_LS180_Human	0.91320670
98	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.91230322
99	ERG_20517297_ChIP-Seq_VCAP_Human	0.90640725
100	SOX2_21211035_ChIP-Seq_LN229_Human	0.88752370

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005408_hypopigmentation	3.95080898
2	MP0003724_increased_susceptibility_to	3.75489221
3	MP0002102_abnormal_ear_morphology	3.32513595
4	MP0005075_abnormal_melanosome_morpholog	2.96692136
5	MP0005671_abnormal_response_to	2.84872007
6	MP0000372_irregular_coat_pigmentation	2.84203643
7	MP0003718_maternal_effect	2.61442270
8	MP0005645_abnormal_hypothalamus_physiol	2.38008227
9	MP0003786_premature_aging	2.37193521
10	MP0004145_abnormal_muscle_electrophysio	2.34853023
11	MP0003646_muscle_fatigue	2.31953654
12	MP0001905_abnormal_dopamine_level	2.22174581
13	MP0002837_dystrophic_cardiac_calcinosis	2.18656448
14	MP0002138_abnormal_hepatobiliary_system	2.15030460
15	MP0002638_abnormal_pupillary_reflex	2.07497944
16	MP0004142_abnormal_muscle_tone	2.06975089
17	MP0006292_abnormal_olfactory_placode	1.91356855
18	MP0003880_abnormal_central_pattern	1.90773244
19	MP0006072_abnormal_retinal_apoptosis	1.90397967
20	MP0005551_abnormal_eye_electrophysiolog	1.84860853
21	MP0005646_abnormal_pituitary_gland	1.77331819
22	MP0008872_abnormal_physiological_respon	1.71746855
23	MP0001919_abnormal_reproductive_system	1.70254882
24	MP0009379_abnormal_foot_pigmentation	1.64729091
25	MP0004381_abnormal_hair_follicle	1.55427600
26	MP0005389_reproductive_system_phenotype	1.49931877
27	MP0005379_endocrine/exocrine_gland_phen	1.48775443
28	MP0002095_abnormal_skin_pigmentation	1.47020060
29	MP0005464_abnormal_platelet_physiology	1.42479905
30	MP0006276_abnormal_autonomic_nervous	1.40663957
31	MP0003693_abnormal_embryo_hatching	1.39236704
32	MP0000631_abnormal_neuroendocrine_gland	1.36292983
33	MP0005174_abnormal_tail_pigmentation	1.36060472
34	MP0002006_tumorigenesis	1.34849281
35	MP0009046_muscle_twitch	1.33709759
36	MP0003011_delayed_dark_adaptation	1.32127128
37	MP0008877_abnormal_DNA_methylation	1.28433648
38	MP0008775_abnormal_heart_ventricle	1.27963022
39	MP0009745_abnormal_behavioral_response	1.27961395
40	MP0009785_altered_susceptibility_to	1.21809079
41	MP0002272_abnormal_nervous_system	1.21470221
42	MP0006036_abnormal_mitochondrial_physio	1.20222575
43	MP0000371_diluted_coat_color	1.19895543
44	MP0008875_abnormal_xenobiotic_pharmacok	1.14550073
45	MP0005084_abnormal_gallbladder_morpholo	1.12702364
46	MP0003567_abnormal_fetal_cardiomyocyte	1.12539927
47	MP0002166_altered_tumor_susceptibility	1.12531931
48	MP0003638_abnormal_response/metabolism_	1.11042639
49	MP0005410_abnormal_fertilization	1.10208697
50	MP0003890_abnormal_embryonic-extraembry	1.10111489
51	MP0001119_abnormal_female_reproductive	1.09720399
52	MP0005423_abnormal_somatic_nervous	1.06407430
53	MP0005167_abnormal_blood-brain_barrier	1.05741064
54	MP0002751_abnormal_autonomic_nervous	1.05274581
55	MP0002160_abnormal_reproductive_system	1.04145560
56	MP0000427_abnormal_hair_cycle	1.03763625
57	MP0004133_heterotaxia	1.03474479
58	MP0002653_abnormal_ependyma_morphology	1.03120914
59	MP0001984_abnormal_olfaction	1.00696507
60	MP0005000_abnormal_immune_tolerance	0.98707454
61	MP0003866_abnormal_defecation	0.97940925
62	MP0005636_abnormal_mineral_homeostasis	0.95262846
63	MP0008057_abnormal_DNA_replication	0.93093616
64	MP0008995_early_reproductive_senescence	0.92752194
65	MP0003878_abnormal_ear_physiology	0.92445420
66	MP0005377_hearing/vestibular/ear_phenot	0.92445420
67	MP0002075_abnormal_coat/hair_pigmentati	0.92361368
68	MP0001970_abnormal_pain_threshold	0.91449505
69	MP0005332_abnormal_amino_acid	0.91315026
70	MP0001485_abnormal_pinna_reflex	0.90348212
71	MP0005253_abnormal_eye_physiology	0.90291100
72	MP0002064_seizures	0.89691721
73	MP0009333_abnormal_splenocyte_physiolog	0.88766891
74	MP0000569_abnormal_digit_pigmentation	0.88331923
75	MP0003937_abnormal_limbs/digits/tail_de	0.87399903
76	MP0002210_abnormal_sex_determination	0.85952611
77	MP0000015_abnormal_ear_pigmentation	0.85605421
78	MP0001186_pigmentation_phenotype	0.85583144
79	MP0003045_fibrosis	0.85308195
80	MP0004134_abnormal_chest_morphology	0.84215095
81	MP0002282_abnormal_trachea_morphology	0.84163694
82	MP0004885_abnormal_endolymph	0.82799728
83	MP0001324_abnormal_eye_pigmentation	0.82556664
84	MP0002234_abnormal_pharynx_morphology	0.82040535
85	MP0002277_abnormal_respiratory_mucosa	0.80569366
86	MP0002736_abnormal_nociception_after	0.80047642
87	MP0000230_abnormal_systemic_arterial	0.77042654
88	MP0001853_heart_inflammation	0.76160151
89	MP0005395_other_phenotype	0.75923686
90	MP0002572_abnormal_emotion/affect_behav	0.75787782
91	MP0001188_hyperpigmentation	0.75753148
92	MP0002139_abnormal_hepatobiliary_system	0.75726967
93	MP0008058_abnormal_DNA_repair	0.75034679
94	MP0000653_abnormal_sex_gland	0.73505708
95	MP0000049_abnormal_middle_ear	0.72780709
96	MP0001765_abnormal_ion_homeostasis	0.72304637
97	MP0001968_abnormal_touch/_nociception	0.71349100
98	MP0001756_abnormal_urination	0.71038399
99	MP0005083_abnormal_biliary_tract	0.69615127
100	MP0001929_abnormal_gametogenesis	0.69547704

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Decreased central vision (HP:0007663)	3.78938545
2	Congenital stationary night blindness (HP:0007642)	3.61416641
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.47705802
4	Abnormality of alanine metabolism (HP:0010916)	3.47705802
5	Hyperalaninemia (HP:0003348)	3.47705802
6	Osteomalacia (HP:0002749)	3.10075865
7	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.06333153
8	Abnormality of the nasal septum (HP:0000419)	2.92476225
9	Abnormal mitochondria in muscle tissue (HP:0008316)	2.89844203
10	Erythroderma (HP:0001019)	2.87750674
11	Hepatocellular necrosis (HP:0001404)	2.82582245
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.81124993
13	Abnormality of midbrain morphology (HP:0002418)	2.77102071
14	Molar tooth sign on MRI (HP:0002419)	2.77102071
15	Acute necrotizing encephalopathy (HP:0006965)	2.76222176
16	Abnormal rod and cone electroretinograms (HP:0008323)	2.72962295
17	Aplastic anemia (HP:0001915)	2.71683332
18	Congenital ichthyosiform erythroderma (HP:0007431)	2.63104618
19	Type I transferrin isoform profile (HP:0003642)	2.61910872
20	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.61852253
21	Pancreatic cysts (HP:0001737)	2.59951273
22	Medial flaring of the eyebrow (HP:0010747)	2.56272372
23	Hepatic necrosis (HP:0002605)	2.54943917
24	Type 2 muscle fiber atrophy (HP:0003554)	2.54001576
25	Acute encephalopathy (HP:0006846)	2.49578969
26	Aqueductal stenosis (HP:0002410)	2.46528402
27	Progressive macrocephaly (HP:0004481)	2.45553382
28	Hypoplasia of the uterus (HP:0000013)	2.43397483
29	Abnormality of urine glucose concentration (HP:0011016)	2.42944800
30	Glycosuria (HP:0003076)	2.42944800
31	IgG deficiency (HP:0004315)	2.41721152
32	Increased CSF lactate (HP:0002490)	2.41382012
33	True hermaphroditism (HP:0010459)	2.41125889
34	Meckel diverticulum (HP:0002245)	2.39069801
35	Abolished electroretinogram (ERG) (HP:0000550)	2.38792500
36	Mitochondrial inheritance (HP:0001427)	2.36244536
37	Pancreatic fibrosis (HP:0100732)	2.32825810
38	Abnormality of the labia minora (HP:0012880)	2.32262647
39	Pigmentary retinal degeneration (HP:0001146)	2.28867958
40	Abnormality of dental color (HP:0011073)	2.28555613
41	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.26782150
42	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.25628315
43	Alveolar cell carcinoma (HP:0006519)	2.23090303
44	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.23017071
45	Abnormality of the ileum (HP:0001549)	2.22242550
46	Increased serum lactate (HP:0002151)	2.20857103
47	Gait imbalance (HP:0002141)	2.20840882
48	Congenital primary aphakia (HP:0007707)	2.19850372
49	Short tibia (HP:0005736)	2.18684952
50	Abnormality of the neuromuscular junction (HP:0003398)	2.17073802
51	Fatigable weakness (HP:0003473)	2.17073802
52	Short hallux (HP:0010109)	2.16896927
53	Pendular nystagmus (HP:0012043)	2.16343918
54	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.15920140
55	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.14637610
56	Muscle fiber atrophy (HP:0100295)	2.10921576
57	Clubbing of toes (HP:0100760)	2.10374682
58	Abnormal pancreas size (HP:0012094)	2.09824699
59	Anencephaly (HP:0002323)	2.08607442
60	Abnormal protein glycosylation (HP:0012346)	2.06391436
61	Abnormal glycosylation (HP:0012345)	2.06391436
62	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.06391436
63	Abnormal protein N-linked glycosylation (HP:0012347)	2.06391436
64	Aplasia/hypoplasia of the uterus (HP:0008684)	2.05188831
65	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.04000904
66	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.01950574
67	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.01950574
68	Sparse eyelashes (HP:0000653)	2.01602383
69	Bundle branch block (HP:0011710)	1.99294502
70	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.98870604
71	Abnormality of the prostate (HP:0008775)	1.98691175
72	Failure to thrive in infancy (HP:0001531)	1.98540373
73	3-Methylglutaconic aciduria (HP:0003535)	1.97236371
74	Abnormality of transition element cation homeostasis (HP:0011030)	1.94983077
75	Generalized aminoaciduria (HP:0002909)	1.94550325
76	Renal cortical cysts (HP:0000803)	1.94533124
77	Recurrent corneal erosions (HP:0000495)	1.93463198
78	Stomach cancer (HP:0012126)	1.92289636
79	Congenital sensorineural hearing impairment (HP:0008527)	1.90354367
80	Parakeratosis (HP:0001036)	1.90294573
81	Chorioretinal atrophy (HP:0000533)	1.89129134
82	Attenuation of retinal blood vessels (HP:0007843)	1.88445823
83	Absent thumb (HP:0009777)	1.88076768
84	Hypoproteinemia (HP:0003075)	1.86092978
85	Oligohydramnios (HP:0001562)	1.84198387
86	Neoplasm of the tracheobronchial system (HP:0100552)	1.83998815
87	Nephrogenic diabetes insipidus (HP:0009806)	1.83401046
88	Drooling (HP:0002307)	1.83242554
89	Increased corneal curvature (HP:0100692)	1.79775768
90	Keratoconus (HP:0000563)	1.79775768
91	Abnormality of the middle phalanges of the toes (HP:0010183)	1.79039940
92	Hypoplasia of the pons (HP:0012110)	1.78791629
93	Maternal diabetes (HP:0009800)	1.78781213
94	Oligodactyly (hands) (HP:0001180)	1.78183695
95	Cerebral palsy (HP:0100021)	1.77777365
96	Epidermoid cyst (HP:0200040)	1.77461720
97	Abnormality of the preputium (HP:0100587)	1.77184942
98	Abnormality of serum amino acid levels (HP:0003112)	1.77022241
99	Male pseudohermaphroditism (HP:0000037)	1.73676599
100	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.73387058

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	3.93590849
2	MAPKAPK3	3.65591553
3	TEC	3.09542356
4	MST4	2.84376007
5	TAOK3	2.83494977
6	ADRBK2	2.53522749
7	GRK1	2.42841012
8	PLK4	2.21000582
9	PLK2	2.07601809
10	ZAK	2.06161497
11	BMPR2	2.03056261
12	NUAK1	1.98608778
13	MAP4K2	1.95862960
14	KDR	1.94862165
15	TRPM7	1.93857414
16	ITK	1.93590435
17	CDK19	1.80259630
18	TLK1	1.78157636
19	BCKDK	1.77071637
20	RPS6KA4	1.64107792
21	WNK3	1.60108042
22	OBSCN	1.57525702
23	VRK1	1.53462782
24	FRK	1.53357414
25	MATK	1.32846972
26	LIMK1	1.31207622
27	NME1	1.29878789
28	BMPR1B	1.29019729
29	OXSR1	1.22961693
30	STK24	1.22701471
31	VRK2	1.21531449
32	TRIM28	1.20761529
33	ERBB3	1.19521452
34	CSNK1G1	1.12921406
35	MAPK13	1.12680465
36	CSNK1G2	1.08703703
37	FLT3	0.99371824
38	FER	0.99121334
39	CSNK1G3	0.94325261
40	PRKCI	0.93729781
41	BUB1	0.91991087
42	IKBKB	0.91577905
43	WNK4	0.91240450
44	PIK3CG	0.90042281
45	TNIK	0.90019780
46	MYLK	0.89173171
47	DYRK3	0.88755168
48	TXK	0.88662121
49	PRKCQ	0.88279092
50	PTK2B	0.87869441
51	BTK	0.85753491
52	TESK2	0.76787081
53	INSRR	0.76421539
54	CDC7	0.75982137
55	DYRK2	0.75677484
56	AURKA	0.75451561
57	RPS6KA5	0.74633861
58	DAPK1	0.73301682
59	MAP3K12	0.69318811
60	SCYL2	0.68182470
61	FES	0.63407560
62	ADRBK1	0.62181380
63	GRK6	0.57130129
64	PLK3	0.56809632
65	CHEK2	0.56647871
66	CSNK1A1	0.56435952
67	PAK1	0.56161030
68	PRKCE	0.55583328
69	PRKD3	0.55429065
70	ROCK1	0.55426132
71	KIT	0.54869798
72	CAMK2A	0.54199068
73	PAK3	0.52668684
74	MARK1	0.52551822
75	PINK1	0.52206502
76	ILK	0.52165189
77	STK39	0.51521917
78	CHUK	0.51005684
79	PDK2	0.48897766
80	CSK	0.47371242
81	MAP4K1	0.46477861
82	IGF1R	0.46220551
83	MAP2K7	0.45900065
84	PRKG2	0.45169505
85	CASK	0.43811378
86	CSNK2A1	0.42656982
87	CSNK1A1L	0.42534837
88	TNK2	0.41862157
89	AKT3	0.40834626
90	ERBB2	0.39582429
91	PHKG2	0.39192848
92	PHKG1	0.39192848
93	CCNB1	0.38805664
94	LCK	0.37679833
95	ERBB4	0.36775804
96	CAMK2B	0.36166077
97	PRKCA	0.35953065
98	PRKACA	0.35532586
99	MAPKAPK5	0.33979450
100	DYRK1A	0.30301871

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.58784435
2	Protein export_Homo sapiens_hsa03060	3.36796385
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.94193295
4	RNA polymerase_Homo sapiens_hsa03020	2.58754076
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.57435650
6	Parkinsons disease_Homo sapiens_hsa05012	2.49625922
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.30195362
8	Phototransduction_Homo sapiens_hsa04744	2.23845494
9	Asthma_Homo sapiens_hsa05310	2.19896131
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.07887859
11	Allograft rejection_Homo sapiens_hsa05330	2.03959916
12	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.95599683
13	Homologous recombination_Homo sapiens_hsa03440	1.90741895
14	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.89392715
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.87983682
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.87786761
17	Type I diabetes mellitus_Homo sapiens_hsa04940	1.84775651
18	Sulfur metabolism_Homo sapiens_hsa00920	1.79356561
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.74324953
20	Antigen processing and presentation_Homo sapiens_hsa04612	1.73846908
21	One carbon pool by folate_Homo sapiens_hsa00670	1.68141393
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.65974936
23	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.60424993
24	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.58057015
25	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.57808573
26	Nicotine addiction_Homo sapiens_hsa05033	1.53243964
27	Mismatch repair_Homo sapiens_hsa03430	1.47285439
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.46318165
29	Chemical carcinogenesis_Homo sapiens_hsa05204	1.38141297
30	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.37384127
31	Ribosome_Homo sapiens_hsa03010	1.37311378
32	Alzheimers disease_Homo sapiens_hsa05010	1.37032251
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.33076502
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.28724199
35	Huntingtons disease_Homo sapiens_hsa05016	1.28359617
36	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.19842368
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.19642544
38	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.18498672
39	RNA degradation_Homo sapiens_hsa03018	1.13672671
40	Caffeine metabolism_Homo sapiens_hsa00232	1.13355275
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.09565648
42	Basal transcription factors_Homo sapiens_hsa03022	1.07609307
43	Rheumatoid arthritis_Homo sapiens_hsa05323	1.04009050
44	Tryptophan metabolism_Homo sapiens_hsa00380	1.00548974
45	Nitrogen metabolism_Homo sapiens_hsa00910	0.99750782
46	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.99411636
47	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.98571360
48	Olfactory transduction_Homo sapiens_hsa04740	0.96700612
49	Selenocompound metabolism_Homo sapiens_hsa00450	0.95912545
50	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.94201237
51	Linoleic acid metabolism_Homo sapiens_hsa00591	0.89528017
52	Retinol metabolism_Homo sapiens_hsa00830	0.85009157
53	DNA replication_Homo sapiens_hsa03030	0.84460396
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.84296025
55	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.83391028
56	Taste transduction_Homo sapiens_hsa04742	0.81461164
57	Purine metabolism_Homo sapiens_hsa00230	0.81280652
58	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.79877402
59	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.78465341
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.78008114
61	Peroxisome_Homo sapiens_hsa04146	0.74760334
62	Glutathione metabolism_Homo sapiens_hsa00480	0.73889771
63	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.73830228
64	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.72595686
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.72225916
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.72155063
67	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.71304997
68	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.69425380
69	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.68264258
70	Nucleotide excision repair_Homo sapiens_hsa03420	0.67709451
71	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.66859986
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.66631228
73	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.65678430
74	Pyrimidine metabolism_Homo sapiens_hsa00240	0.64279679
75	Morphine addiction_Homo sapiens_hsa05032	0.62272561
76	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.60897830
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.58521077
78	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.58119528
79	Propanoate metabolism_Homo sapiens_hsa00640	0.57760967
80	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.55977658
81	Vibrio cholerae infection_Homo sapiens_hsa05110	0.55338690
82	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.53790977
83	Metabolic pathways_Homo sapiens_hsa01100	0.53330217
84	Folate biosynthesis_Homo sapiens_hsa00790	0.52245327
85	Butanoate metabolism_Homo sapiens_hsa00650	0.48119610
86	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.47235702
87	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.43565159
88	Steroid biosynthesis_Homo sapiens_hsa00100	0.42419893
89	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.41181990
90	Sulfur relay system_Homo sapiens_hsa04122	0.37869680
91	Viral myocarditis_Homo sapiens_hsa05416	0.37644493
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.36858440
93	Pancreatic secretion_Homo sapiens_hsa04972	0.36785555
94	Circadian entrainment_Homo sapiens_hsa04713	0.36309152
95	Salivary secretion_Homo sapiens_hsa04970	0.36101897
96	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33358929
97	GABAergic synapse_Homo sapiens_hsa04727	0.32174752
98	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.29401393
99	Serotonergic synapse_Homo sapiens_hsa04726	0.27882956
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.25983767

PSMC1P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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