PSMC1P11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine ribonucleoside catabolic process (GO:0046133)9.47220084
2DNA deamination (GO:0045006)9.21089707
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.54566401
4positive regulation of interleukin-8 secretion (GO:2000484)4.88955204
5negative regulation by host of viral transcription (GO:0043922)4.86593139
6Arp2/3 complex-mediated actin nucleation (GO:0034314)4.76932482
7eosinophil chemotaxis (GO:0048245)4.76257124
8pyrimidine nucleoside catabolic process (GO:0046135)4.48996200
9sequestering of actin monomers (GO:0042989)4.47243604
10protein neddylation (GO:0045116)4.34749088
11positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.29032899
12eosinophil migration (GO:0072677)4.28690009
13actin nucleation (GO:0045010)4.19039681
14positive T cell selection (GO:0043368)4.12043007
15positive regulation of natural killer cell mediated immunity (GO:0002717)4.11868952
16positive thymic T cell selection (GO:0045059)4.11570798
17T cell migration (GO:0072678)4.08505377
18cytolysis (GO:0019835)4.07172784
19iron-sulfur cluster assembly (GO:0016226)4.00858286
20metallo-sulfur cluster assembly (GO:0031163)4.00858286
21negative regulation of T cell apoptotic process (GO:0070233)3.96630906
22regulation of lymphocyte chemotaxis (GO:1901623)3.94145113
23regulation of cellular amino acid metabolic process (GO:0006521)3.90214212
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.89688959
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.81938600
26establishment of protein localization to mitochondrial membrane (GO:0090151)3.80638194
27proteasome assembly (GO:0043248)3.75452450
28negative regulation of viral genome replication (GO:0045071)3.72635634
29positive regulation of calcium-mediated signaling (GO:0050850)3.71795509
30macrophage chemotaxis (GO:0048246)3.70485318
31positive regulation of T cell chemotaxis (GO:0010820)3.67041166
32regulation of T cell chemotaxis (GO:0010819)3.67041166
33DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.65767858
34DNA demethylation (GO:0080111)3.60771822
35negative regulation of ligase activity (GO:0051352)3.59720937
36negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.59720937
37regulation of regulatory T cell differentiation (GO:0045589)3.59327425
38energy coupled proton transport, down electrochemical gradient (GO:0015985)3.58627665
39ATP synthesis coupled proton transport (GO:0015986)3.58627665
40mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.55516313
41signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.55414840
42signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.55414840
43signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.55414840
44signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.54628130
45intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.54628130
46regulation of interleukin-8 secretion (GO:2000482)3.50189363
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.45881453
48respiratory electron transport chain (GO:0022904)3.45828023
49NIK/NF-kappaB signaling (GO:0038061)3.41840121
50electron transport chain (GO:0022900)3.40665453
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.38851661
52lymphocyte chemotaxis (GO:0048247)3.37999700
53signal transduction involved in DNA damage checkpoint (GO:0072422)3.37697298
54signal transduction involved in DNA integrity checkpoint (GO:0072401)3.37697298
55positive regulation of monocyte chemotaxis (GO:0090026)3.36842413
56signal transduction involved in cell cycle checkpoint (GO:0072395)3.35166477
57positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.34425454
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.33830439
59regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.29322382
60regulation of natural killer cell mediated immunity (GO:0002715)3.29322382
61positive regulation of tolerance induction (GO:0002645)3.26320502
62pyrimidine-containing compound catabolic process (GO:0072529)3.17326261
63positive regulation of lymphocyte migration (GO:2000403)3.17214186
64chaperone-mediated protein transport (GO:0072321)3.16680960
65regulation of T cell tolerance induction (GO:0002664)3.13555172
66RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.13482827
67tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.13482827
68antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.11302406
69negative regulation of viral transcription (GO:0032897)3.11187654
70DNA dealkylation (GO:0035510)3.09496564
71monocyte chemotaxis (GO:0002548)3.04597862
72platelet dense granule organization (GO:0060155)3.03246185
73piRNA metabolic process (GO:0034587)3.01264589
74male meiosis I (GO:0007141)3.00307280
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.99225437
76positive regulation of cell killing (GO:0031343)2.96693165
77positive regulation of translational initiation (GO:0045948)2.96108133
78regulation of chronic inflammatory response (GO:0002676)2.94663569
79positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.91032395
80nucleoside diphosphate catabolic process (GO:0009134)2.89631674
81protein complex biogenesis (GO:0070271)2.88988386
82transcription elongation from RNA polymerase III promoter (GO:0006385)2.88704968
83termination of RNA polymerase III transcription (GO:0006386)2.88704968
84regulation of leukocyte mediated cytotoxicity (GO:0001910)2.86222356
85regulation of cellular amine metabolic process (GO:0033238)2.86062533
86negative T cell selection (GO:0043383)2.85825897
87regulation of activation of Janus kinase activity (GO:0010533)2.83584989
88positive regulation of ligase activity (GO:0051351)2.83302437
89modulation by host of viral transcription (GO:0043921)2.81979439
90modulation by host of symbiont transcription (GO:0052472)2.81979439
91positive regulation of cell cycle arrest (GO:0071158)2.81024314
92positive regulation of T cell apoptotic process (GO:0070234)2.79481281
93positive regulation of interleukin-1 beta secretion (GO:0050718)2.78669062
94pyrimidine ribonucleoside metabolic process (GO:0046131)2.75853735
95regulation of calcium-mediated signaling (GO:0050848)2.74304846
96negative regulation of lymphocyte apoptotic process (GO:0070229)2.71446590
97DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.71410334
98cytidine metabolic process (GO:0046087)10.5215224
99cytidine catabolic process (GO:0006216)10.5215224
100cytidine deamination (GO:0009972)10.5215224

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.11952841
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.55244840
3ELF1_17652178_ChIP-ChIP_JURKAT_Human4.37129381
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.27333777
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.80908837
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.54937823
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.52592426
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90717290
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.69519920
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.65449143
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.61127349
12VDR_23849224_ChIP-Seq_CD4+_Human2.31272641
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.22756527
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.14104798
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13354443
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07136641
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01903562
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.97536170
19VDR_22108803_ChIP-Seq_LS180_Human1.94057507
20FOXP3_21729870_ChIP-Seq_TREG_Human1.93866352
21IGF1R_20145208_ChIP-Seq_DFB_Human1.90792363
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78364948
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73503760
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68134752
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67805524
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66278914
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.65944869
28MYB_26560356_Chip-Seq_TH2_Human1.60803924
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60735829
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.56560481
31HTT_18923047_ChIP-ChIP_STHdh_Human1.54406237
32RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.53982736
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.50858875
34EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.48008233
35ELK1_19687146_ChIP-ChIP_HELA_Human1.47744090
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46248670
37GATA3_27048872_Chip-Seq_THYMUS_Human1.43331033
38ZNF274_21170338_ChIP-Seq_K562_Hela1.39137538
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38116955
40TAF2_19829295_ChIP-Seq_ESCs_Human1.35122145
41GATA3_26560356_Chip-Seq_TH2_Human1.35087210
42TP53_22573176_ChIP-Seq_HFKS_Human1.34071109
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33764678
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.33017193
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32890746
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29165131
47EZH2_22144423_ChIP-Seq_EOC_Human1.26114576
48PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.24755420
49YY1_22570637_ChIP-Seq_MALME-3M_Human1.19900758
50BCL6_27268052_Chip-Seq_Bcells_Human1.19662187
51CIITA_25753668_ChIP-Seq_RAJI_Human1.18192367
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.17609823
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16260310
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.16260310
55NANOG_20526341_ChIP-Seq_ESCs_Human1.16225105
56PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15940691
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15019818
58AR_20517297_ChIP-Seq_VCAP_Human1.14896488
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12501260
60MYC_19829295_ChIP-Seq_ESCs_Human1.11816928
61GABP_19822575_ChIP-Seq_HepG2_Human1.11807849
62MYC_18940864_ChIP-ChIP_HL60_Human1.11804230
63ERG_20517297_ChIP-Seq_VCAP_Human1.11698726
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.10910971
65ERA_21632823_ChIP-Seq_H3396_Human1.10575361
66TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09314705
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08855861
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08483198
69FOXH1_21741376_ChIP-Seq_EPCs_Human1.06682186
70FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06648668
71DCP1A_22483619_ChIP-Seq_HELA_Human1.06617603
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05700732
73P300_27268052_Chip-Seq_Bcells_Human1.02149189
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01943767
75GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01424458
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01121779
77SOX2_19829295_ChIP-Seq_ESCs_Human1.00874391
78NANOG_19829295_ChIP-Seq_ESCs_Human1.00874391
79AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99792631
80ELF1_20517297_ChIP-Seq_JURKAT_Human0.99768527
81ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98910168
82HOXB7_26014856_ChIP-Seq_BT474_Human0.98209375
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97747311
84GATA6_21074721_ChIP-Seq_CACO-2_Human0.97439982
85CTCF_20526341_ChIP-Seq_ESCs_Human0.96883449
86FLI1_27457419_Chip-Seq_LIVER_Mouse0.94705453
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93889371
88GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93774717
89E2F4_17652178_ChIP-ChIP_JURKAT_Human0.93735879
90RBPJ_21746931_ChIP-Seq_IB4_Human0.93379207
91P53_21459846_ChIP-Seq_SAOS-2_Human0.92968685
92UTX_26944678_Chip-Seq_JUKART_Human0.92950253
93RUNX_20019798_ChIP-Seq_JUKART_Human0.92738376
94NCOR_22424771_ChIP-Seq_293T_Human0.92715569
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92288881
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91738517
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91345776
98OCT4_20526341_ChIP-Seq_ESCs_Human0.91329910
99MAF_26560356_Chip-Seq_TH2_Human0.89908469
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89706871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.69634624
2MP0003878_abnormal_ear_physiology3.41074056
3MP0005377_hearing/vestibular/ear_phenot3.41074056
4MP0009333_abnormal_splenocyte_physiolog3.35728794
5MP0009785_altered_susceptibility_to2.89435395
6MP0006082_CNS_inflammation2.80619393
7MP0003763_abnormal_thymus_physiology2.44043782
8MP0002163_abnormal_gland_morphology2.16614440
9MP0008877_abnormal_DNA_methylation2.15090601
10MP0002102_abnormal_ear_morphology2.11941528
11MP0001905_abnormal_dopamine_level2.11175387
12MP0005410_abnormal_fertilization2.05172147
13MP0002148_abnormal_hypersensitivity_rea2.02470295
14MP0003866_abnormal_defecation1.98999232
15MP0005000_abnormal_immune_tolerance1.82796198
16MP0001800_abnormal_humoral_immune1.77774766
17MP0002138_abnormal_hepatobiliary_system1.75591318
18MP0001835_abnormal_antigen_presentation1.73765510
19MP0005645_abnormal_hypothalamus_physiol1.72993197
20MP0002420_abnormal_adaptive_immunity1.68320189
21MP0002723_abnormal_immune_serum1.67936524
22MP0005025_abnormal_response_to1.67047287
23MP0001819_abnormal_immune_cell1.61083209
24MP0003448_altered_tumor_morphology1.58977589
25MP0003786_premature_aging1.58413694
26MP0001188_hyperpigmentation1.56496940
27MP0004145_abnormal_muscle_electrophysio1.51200311
28MP0001968_abnormal_touch/_nociception1.51004917
29MP0002166_altered_tumor_susceptibility1.47634327
30MP0008789_abnormal_olfactory_epithelium1.46623777
31MP0001485_abnormal_pinna_reflex1.38329802
32MP0006035_abnormal_mitochondrial_morpho1.34815571
33MP0001790_abnormal_immune_system1.34359546
34MP0005387_immune_system_phenotype1.34359546
35MP0005379_endocrine/exocrine_gland_phen1.34203108
36MP0003787_abnormal_imprinting1.34058850
37MP0002837_dystrophic_cardiac_calcinosis1.30383162
38MP0002006_tumorigenesis1.29781220
39MP0005075_abnormal_melanosome_morpholog1.27472374
40MP0002638_abnormal_pupillary_reflex1.26737267
41MP0002405_respiratory_system_inflammati1.26396052
42MP0000716_abnormal_immune_system1.26160755
43MP0000372_irregular_coat_pigmentation1.26051687
44MP0006292_abnormal_olfactory_placode1.25891544
45MP0009764_decreased_sensitivity_to1.24356746
46MP0001873_stomach_inflammation1.21939807
47MP0002452_abnormal_antigen_presenting1.20862658
48MP0000703_abnormal_thymus_morphology1.20057798
49MP0005389_reproductive_system_phenotype1.19833445
50MP0002398_abnormal_bone_marrow1.18163015
51MP0001919_abnormal_reproductive_system1.17646250
52MP0003045_fibrosis1.17514090
53MP0010155_abnormal_intestine_physiology1.16948876
54MP0003567_abnormal_fetal_cardiomyocyte1.14616199
55MP0002933_joint_inflammation1.10077777
56MP0002722_abnormal_immune_system1.08329183
57MP0002876_abnormal_thyroid_physiology1.07000016
58MP0005551_abnormal_eye_electrophysiolog1.06673439
59MP0000689_abnormal_spleen_morphology1.06055230
60MP0001929_abnormal_gametogenesis1.05264317
61MP0008872_abnormal_physiological_respon1.05172303
62MP0009763_increased_sensitivity_to1.04009811
63MP0004147_increased_porphyrin_level1.03531436
64MP0001845_abnormal_inflammatory_respons1.03229632
65MP0002909_abnormal_adrenal_gland1.00908695
66MP0006036_abnormal_mitochondrial_physio1.00275006
67MP0005670_abnormal_white_adipose0.98768056
68MP0003137_abnormal_impulse_conducting0.96302621
69MP0001984_abnormal_olfaction0.94679113
70MP0000685_abnormal_immune_system0.93601569
71MP0002210_abnormal_sex_determination0.93107615
72MP0002429_abnormal_blood_cell0.92654102
73MP0002234_abnormal_pharynx_morphology0.92473506
74MP0005394_taste/olfaction_phenotype0.91814690
75MP0005499_abnormal_olfactory_system0.91814690
76MP0002160_abnormal_reproductive_system0.91157668
77MP0001119_abnormal_female_reproductive0.91044206
78MP0009765_abnormal_xenobiotic_induced0.90008522
79MP0000013_abnormal_adipose_tissue0.89791950
80MP0001529_abnormal_vocalization0.89426450
81MP0005310_abnormal_salivary_gland0.89032014
82MP0009745_abnormal_behavioral_response0.86198608
83MP0005253_abnormal_eye_physiology0.85867958
84MP0010307_abnormal_tumor_latency0.85164449
85MP0003693_abnormal_embryo_hatching0.83467346
86MP0006276_abnormal_autonomic_nervous0.83392470
87MP0002736_abnormal_nociception_after0.83310987
88MP0003136_yellow_coat_color0.83248106
89MP0002095_abnormal_skin_pigmentation0.82209797
90MP0009379_abnormal_foot_pigmentation0.81616152
91MP0008873_increased_physiological_sensi0.81381954
92MP0003283_abnormal_digestive_organ0.81209962
93MP0003718_maternal_effect0.79669826
94MP0006054_spinal_hemorrhage0.78926336
95MP0003698_abnormal_male_reproductive0.78216131
96MP0001986_abnormal_taste_sensitivity0.77870895
97MP0008469_abnormal_protein_level0.77084244
98MP0008875_abnormal_xenobiotic_pharmacok0.76925824
99MP0001881_abnormal_mammary_gland0.72383155
100MP0004957_abnormal_blastocyst_morpholog0.70968229

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.93691857
2Abnormality of T cell number (HP:0011839)4.79292292
3Aplastic anemia (HP:0001915)4.66417388
4Severe combined immunodeficiency (HP:0004430)4.49175609
5Acute necrotizing encephalopathy (HP:0006965)4.41950529
6Mitochondrial inheritance (HP:0001427)4.30465628
7Abnormal mitochondria in muscle tissue (HP:0008316)4.04931141
8Autoimmune hemolytic anemia (HP:0001890)3.97778260
9IgG deficiency (HP:0004315)3.93267471
10Hepatocellular necrosis (HP:0001404)3.78454633
11Combined immunodeficiency (HP:0005387)3.67787645
12Acute encephalopathy (HP:0006846)3.66421749
13Increased IgM level (HP:0003496)3.62818719
14Abnormality of T cells (HP:0002843)3.56515668
15Increased CSF lactate (HP:0002490)3.53737758
16Abnormality of eosinophils (HP:0001879)3.52620827
17Progressive macrocephaly (HP:0004481)3.52304073
183-Methylglutaconic aciduria (HP:0003535)3.44382186
19Abnormality of midbrain morphology (HP:0002418)3.44145041
20Molar tooth sign on MRI (HP:0002419)3.44145041
21Hepatic necrosis (HP:0002605)3.38759561
22Hypoproteinemia (HP:0003075)3.30677773
23Thyroiditis (HP:0100646)3.27035526
24Decreased activity of mitochondrial respiratory chain (HP:0008972)3.18671800
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.18671800
26Elevated erythrocyte sedimentation rate (HP:0003565)3.16769731
27Pancreatic fibrosis (HP:0100732)3.14490843
28Pancreatic cysts (HP:0001737)3.13617533
29Eosinophilia (HP:0001880)3.09603113
30Cerebral edema (HP:0002181)3.08565691
31Type 2 muscle fiber atrophy (HP:0003554)2.88646145
32Increased intramyocellular lipid droplets (HP:0012240)2.88196030
33Increased hepatocellular lipid droplets (HP:0006565)2.88074881
34True hermaphroditism (HP:0010459)2.77212249
35Hypoplasia of the thymus (HP:0000778)2.72937910
36Renal Fanconi syndrome (HP:0001994)2.70214165
37Leukocytosis (HP:0001974)2.70153325
38Stomatitis (HP:0010280)2.63268178
39Autoimmune thrombocytopenia (HP:0001973)2.63069462
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.57190070
41Muscle fiber atrophy (HP:0100295)2.57175326
42Granulocytopenia (HP:0001913)2.53684976
43Recurrent bronchitis (HP:0002837)2.52927412
44Short tibia (HP:0005736)2.52831340
45Optic disc pallor (HP:0000543)2.45833637
46Lipid accumulation in hepatocytes (HP:0006561)2.38087741
47Lactic acidosis (HP:0003128)2.37109277
48Abnormal albumin level (HP:0012116)2.37051966
49Hypoalbuminemia (HP:0003073)2.37051966
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.34727039
51Abnormal biliary tract physiology (HP:0012439)2.33939299
52Bile duct proliferation (HP:0001408)2.33939299
53Generalized aminoaciduria (HP:0002909)2.31376114
54Recurrent cutaneous fungal infections (HP:0011370)2.26157121
55Chronic mucocutaneous candidiasis (HP:0002728)2.26157121
56Amyotrophic lateral sclerosis (HP:0007354)2.21756060
57Increased serum lactate (HP:0002151)2.20138239
58Chronic diarrhea (HP:0002028)2.19918457
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18434619
60Increased muscle lipid content (HP:0009058)2.14809651
61Abnormality of T cell physiology (HP:0011840)2.14510406
62Renal cortical cysts (HP:0000803)2.10381849
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.09715359
64Encephalitis (HP:0002383)2.09620896
65Pustule (HP:0200039)2.09294097
66Decreased central vision (HP:0007663)2.09091756
67Attenuation of retinal blood vessels (HP:0007843)2.07890884
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05992622
69Congenital stationary night blindness (HP:0007642)2.02244198
70Medial flaring of the eyebrow (HP:0010747)2.02118980
71Abnormal rod and cone electroretinograms (HP:0008323)2.01025925
72Type I transferrin isoform profile (HP:0003642)2.01012766
73Nephronophthisis (HP:0000090)2.00902630
74Colon cancer (HP:0003003)2.00014461
75Panhypogammaglobulinemia (HP:0003139)1.98059004
76Lymphopenia (HP:0001888)1.96106467
77Respiratory failure (HP:0002878)1.96032352
78Sclerocornea (HP:0000647)1.95870723
79Exercise intolerance (HP:0003546)1.94532781
80Abnormality of the prostate (HP:0008775)1.94407751
81Abnormality of B cell number (HP:0010975)1.94265960
82Cystic liver disease (HP:0006706)1.91562724
83Abnormality of cells of the lymphoid lineage (HP:0012140)1.88293619
84Abnormal protein glycosylation (HP:0012346)1.87289628
85Abnormal glycosylation (HP:0012345)1.87289628
86Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87289628
87Abnormal protein N-linked glycosylation (HP:0012347)1.87289628
88Cerebral hypomyelination (HP:0006808)1.86543123
89Hemiplegia (HP:0002301)1.86387235
90CNS demyelination (HP:0007305)1.84117844
91Aplasia/Hypoplasia of the tongue (HP:0010295)1.83335882
92Pancytopenia (HP:0001876)1.82947619
93Exertional dyspnea (HP:0002875)1.82249804
94Tetany (HP:0001281)1.82121200
95IgM deficiency (HP:0002850)1.79623852
96Abnormality of the renal cortex (HP:0011035)1.79345891
97Leukodystrophy (HP:0002415)1.79003546
98Nephrogenic diabetes insipidus (HP:0009806)1.73261833
99Abnormality of magnesium homeostasis (HP:0004921)1.72339364
100Abolished electroretinogram (ERG) (HP:0000550)1.70843804

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.50410814
2TESK25.00066606
3TXK4.09702228
4MAP4K24.02542756
5VRK22.98630221
6TESK12.85012660
7ADRBK22.38753340
8ZAK2.37111702
9WNK42.35526726
10BCKDK2.34880301
11BUB12.33112047
12LIMK12.05853110
13NUAK11.89601163
14TIE11.82211436
15VRK11.67198480
16MAP4K11.66134435
17TRIM281.64615977
18ITK1.63780525
19FES1.60963570
20STK161.58933118
21PIK3CA1.55476428
22OXSR11.50459580
23STK391.47133091
24SRPK11.38543650
25BMPR1B1.37850852
26PLK41.27535137
27EIF2AK31.25754225
28PRKCQ1.23439333
29GRK11.22857643
30MAP2K71.18559248
31MAPKAPK31.17367100
32GRK71.12381891
33IKBKE1.10544505
34TLK11.03129420
35MAP3K121.01475064
36TAOK31.00491115
37DAPK10.94138355
38BCR0.91885117
39LCK0.90631231
40CSK0.90525982
41INSRR0.85783285
42MAP3K110.85167830
43ARAF0.82595120
44SYK0.82380794
45WNK30.81799160
46FRK0.81569183
47ZAP700.79700874
48PINK10.79533470
49PIM20.79034672
50PIK3CG0.76131678
51TAF10.75293234
52PLK20.72658675
53TYRO30.66377728
54RPS6KA50.66130003
55IKBKB0.63566436
56GRK50.59404210
57LYN0.57503826
58MST40.57065468
59DYRK20.56216488
60TEC0.54223582
61EIF2AK20.51796707
62CSF1R0.47625854
63CSNK1G30.47539858
64AURKA0.46884140
65MAP2K60.44008523
66CSNK2A10.43711010
67MYLK0.41919906
68NEK10.40689526
69PRKCI0.40277438
70CSNK1A10.39848032
71PRKCE0.39126867
72BRSK20.38384898
73PDK20.37862268
74PRKCG0.37715747
75JAK30.37686286
76PLK10.36768757
77FYN0.36543019
78IGF1R0.36354856
79INSR0.36336500
80MAP3K40.34669347
81AURKB0.34213212
82MAPK130.34052980
83CSNK1A1L0.33922412
84CLK10.33844429
85BTK0.33221557
86PRKCA0.33015328
87BRAF0.32723014
88ROCK10.32667389
89ADRBK10.32156700
90RPS6KA40.31192469
91MARK30.30770855
92NEK60.29509389
93EPHB20.28806097
94NME10.27647182
95PLK30.27230476
96CSNK2A20.27173897
97PRKACA0.27037490
98TNIK0.26956490
99KIT0.26175961
100OBSCN0.25387713

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.33636936
2Primary immunodeficiency_Homo sapiens_hsa053404.94296989
3Oxidative phosphorylation_Homo sapiens_hsa001903.68540210
4Parkinsons disease_Homo sapiens_hsa050123.35240682
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.99358165
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.95769299
7Graft-versus-host disease_Homo sapiens_hsa053322.90633784
8RNA polymerase_Homo sapiens_hsa030202.46290971
9Antigen processing and presentation_Homo sapiens_hsa046122.39156781
10Autoimmune thyroid disease_Homo sapiens_hsa053202.35421546
11Allograft rejection_Homo sapiens_hsa053302.19131123
12Huntingtons disease_Homo sapiens_hsa050162.07059081
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.98898746
14Alzheimers disease_Homo sapiens_hsa050101.92205981
15Ribosome_Homo sapiens_hsa030101.90349519
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.86737946
17Type I diabetes mellitus_Homo sapiens_hsa049401.81991714
18Hematopoietic cell lineage_Homo sapiens_hsa046401.67716790
19Protein export_Homo sapiens_hsa030601.66586688
20Rheumatoid arthritis_Homo sapiens_hsa053231.63931178
21T cell receptor signaling pathway_Homo sapiens_hsa046601.62141111
22Homologous recombination_Homo sapiens_hsa034401.58254590
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54260666
24Butanoate metabolism_Homo sapiens_hsa006501.47489357
25Caffeine metabolism_Homo sapiens_hsa002321.34141768
26Cardiac muscle contraction_Homo sapiens_hsa042601.33620824
27Phototransduction_Homo sapiens_hsa047441.32251261
28Collecting duct acid secretion_Homo sapiens_hsa049661.28328806
29Sulfur relay system_Homo sapiens_hsa041221.18444629
30Pyrimidine metabolism_Homo sapiens_hsa002401.11873648
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08519722
32Propanoate metabolism_Homo sapiens_hsa006401.07139475
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01651227
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99045599
35Spliceosome_Homo sapiens_hsa030400.95337225
36Basal transcription factors_Homo sapiens_hsa030220.91544650
37Purine metabolism_Homo sapiens_hsa002300.91134709
38Peroxisome_Homo sapiens_hsa041460.90888743
39Salmonella infection_Homo sapiens_hsa051320.87851653
40Measles_Homo sapiens_hsa051620.85733480
41Fatty acid elongation_Homo sapiens_hsa000620.80180512
42Shigellosis_Homo sapiens_hsa051310.79827030
43RNA degradation_Homo sapiens_hsa030180.78678284
44Intestinal immune network for IgA production_Homo sapiens_hsa046720.74528690
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74347909
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73808929
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73171901
48RNA transport_Homo sapiens_hsa030130.72734974
49Regulation of autophagy_Homo sapiens_hsa041400.71951350
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.68803191
51Fatty acid biosynthesis_Homo sapiens_hsa000610.68221504
52Systemic lupus erythematosus_Homo sapiens_hsa053220.67147071
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66696529
54Selenocompound metabolism_Homo sapiens_hsa004500.65290571
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65286360
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63750442
57Nucleotide excision repair_Homo sapiens_hsa034200.62699560
58Mismatch repair_Homo sapiens_hsa034300.62435093
59Nitrogen metabolism_Homo sapiens_hsa009100.62418485
60Viral myocarditis_Homo sapiens_hsa054160.60644638
61Sulfur metabolism_Homo sapiens_hsa009200.58736778
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57083965
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.56401278
64Asthma_Homo sapiens_hsa053100.56097506
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55761120
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54898246
67Epstein-Barr virus infection_Homo sapiens_hsa051690.54776085
68Olfactory transduction_Homo sapiens_hsa047400.52051861
69Linoleic acid metabolism_Homo sapiens_hsa005910.51615690
70Base excision repair_Homo sapiens_hsa034100.47084811
71DNA replication_Homo sapiens_hsa030300.46444768
72Metabolic pathways_Homo sapiens_hsa011000.46100999
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45724006
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44125014
75Herpes simplex infection_Homo sapiens_hsa051680.43266562
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43222886
77beta-Alanine metabolism_Homo sapiens_hsa004100.42364452
78Fanconi anemia pathway_Homo sapiens_hsa034600.40950211
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40674899
80Fatty acid metabolism_Homo sapiens_hsa012120.37845035
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37338093
82Nicotine addiction_Homo sapiens_hsa050330.37020877
83Chemical carcinogenesis_Homo sapiens_hsa052040.34779156
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.31928476
85Synaptic vesicle cycle_Homo sapiens_hsa047210.31703145
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30880730
87Tryptophan metabolism_Homo sapiens_hsa003800.29978793
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29196400
89Chemokine signaling pathway_Homo sapiens_hsa040620.28850515
90mRNA surveillance pathway_Homo sapiens_hsa030150.27962322
91Fatty acid degradation_Homo sapiens_hsa000710.27139399
92Non-homologous end-joining_Homo sapiens_hsa034500.26105516
93Retinol metabolism_Homo sapiens_hsa008300.25908820
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25793135
95One carbon pool by folate_Homo sapiens_hsa006700.22201284
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.21866087
97Alcoholism_Homo sapiens_hsa050340.21340105
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21187229
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.18105089
100HTLV-I infection_Homo sapiens_hsa051660.17519162

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