ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.34419927
2	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	5.85474499
3	cytidine catabolic process (GO:0006216)	5.70957299
4	cytidine deamination (GO:0009972)	5.70957299
5	cytidine metabolic process (GO:0046087)	5.70957299
6	behavioral response to nicotine (GO:0035095)	5.32873014
7	regulation of cilium movement (GO:0003352)	5.09778850
8	sequestering of actin monomers (GO:0042989)	5.07188685
9	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.02749547
10	antigen processing and presentation via MHC class Ib (GO:0002475)	4.65726630
11	regulation of microtubule-based movement (GO:0060632)	4.63279060
12	striatum development (GO:0021756)	4.55364548
13	kidney morphogenesis (GO:0060993)	4.51940251
14	negative regulation of organelle assembly (GO:1902116)	4.50582854
15	nonmotile primary cilium assembly (GO:0035058)	4.38808562
16	regulation of beta-amyloid formation (GO:1902003)	4.37415757
17	response to pheromone (GO:0019236)	4.27851879
18	negative regulation of interleukin-1 beta production (GO:0032691)	4.25936124
19	atrial cardiac muscle cell action potential (GO:0086014)	4.19218334
20	protein neddylation (GO:0045116)	4.05810716
21	urinary tract smooth muscle contraction (GO:0014848)	3.95884975
22	dendritic cell chemotaxis (GO:0002407)	3.93104638
23	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	3.91585738
24	negative regulation of response to food (GO:0032096)	3.86414427
25	negative regulation of appetite (GO:0032099)	3.86414427
26	positive regulation of CREB transcription factor activity (GO:0032793)	3.85347381
27	postsynaptic membrane organization (GO:0001941)	3.85025463
28	positive regulation of guanylate cyclase activity (GO:0031284)	3.83239564
29	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.76108385
30	positive regulation of synaptic transmission, GABAergic (GO:0032230)	3.74541435
31	sulfate transport (GO:0008272)	3.68254998
32	axoneme assembly (GO:0035082)	3.67739599
33	regulation of response to food (GO:0032095)	3.64407846
34	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	3.58699984
35	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.57128789
36	regulation of appetite (GO:0032098)	3.55545048
37	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.55364213
38	tachykinin receptor signaling pathway (GO:0007217)	3.45368102
39	regulation of guanylate cyclase activity (GO:0031282)	3.44687832
40	cellular response to leptin stimulus (GO:0044320)	3.43777125
41	negative regulation of interleukin-1 production (GO:0032692)	3.43553761
42	pseudouridine synthesis (GO:0001522)	3.42748093
43	regulation of respiratory system process (GO:0044065)	3.42086917
44	protein-cofactor linkage (GO:0018065)	3.41613281
45	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.41162485
46	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.41162485
47	NADH dehydrogenase complex assembly (GO:0010257)	3.41162485
48	ovulation cycle (GO:0042698)	3.36330290
49	negative regulation of lyase activity (GO:0051350)	3.33170436
50	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	3.31017403
51	negative regulation of adenylate cyclase activity (GO:0007194)	3.27081911
52	exogenous drug catabolic process (GO:0042738)	3.26177883
53	positive regulation of respiratory burst (GO:0060267)	3.21557139
54	artery smooth muscle contraction (GO:0014824)	3.18605563
55	regulation of amyloid precursor protein catabolic process (GO:1902991)	3.16659166
56	endoderm formation (GO:0001706)	3.14331461
57	DNA-dependent DNA replication (GO:0006261)	3.12431497
58	negative regulation of cyclase activity (GO:0031280)	3.10145947
59	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.09622369
60	neural tube formation (GO:0001841)	3.09468175
61	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.03927236
62	DNA demethylation (GO:0080111)	3.03605438
63	dendritic cell migration (GO:0036336)	3.02682871
64	synaptic transmission, cholinergic (GO:0007271)	2.98312943
65	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.96860496
66	termination of RNA polymerase III transcription (GO:0006386)	2.95771772
67	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.95771772
68	phasic smooth muscle contraction (GO:0014821)	2.94509615
69	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.92126939
70	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.92126939
71	peristalsis (GO:0030432)	2.88667512
72	positive regulation of mitochondrial fission (GO:0090141)	2.85815073
73	protein complex biogenesis (GO:0070271)	2.84123491
74	piRNA metabolic process (GO:0034587)	2.82906039
75	aldehyde catabolic process (GO:0046185)	2.82707651
76	ATP synthesis coupled proton transport (GO:0015986)	2.80833022
77	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.80833022
78	electron transport chain (GO:0022900)	2.77133959
79	drug catabolic process (GO:0042737)	2.76760891
80	respiratory electron transport chain (GO:0022904)	2.75131694
81	presynaptic membrane organization (GO:0097090)	2.74543755
82	negative regulation of mast cell activation (GO:0033004)	2.74192575
83	negative regulation of meiotic cell cycle (GO:0051447)	2.74054483
84	antigen processing and presentation of endogenous antigen (GO:0019883)	2.72935344
85	acrosome reaction (GO:0007340)	2.71783206
86	positive regulation of antigen processing and presentation (GO:0002579)	2.69769120
87	glial cell proliferation (GO:0014009)	2.68007368
88	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.66262019
89	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.65948167
90	response to leptin (GO:0044321)	2.65406964
91	ncRNA 3-end processing (GO:0043628)	2.64618022
92	epithelial cilium movement (GO:0003351)	2.64455453
93	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.60905208
94	tonic smooth muscle contraction (GO:0014820)	2.60671865
95	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.59597455
96	protein polyglutamylation (GO:0018095)	2.58321838
97	heparin metabolic process (GO:0030202)	2.55270135
98	heparin biosynthetic process (GO:0030210)	2.55270135
99	regulation of meiosis I (GO:0060631)	2.51512234
100	mitochondrial respiratory chain complex assembly (GO:0033108)	2.50132809

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	8.28563309
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.97205956
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.92255788
4	VDR_22108803_ChIP-Seq_LS180_Human	3.18239385
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.81380822
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.46419276
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.30345820
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.18300757
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.06147852
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.02397861
11	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.98192002
12	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.98192002
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.91127732
14	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.88909253
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.88304520
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.86418973
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.85158699
18	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.82682441
19	GBX2_23144817_ChIP-Seq_PC3_Human	1.73275813
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.72269194
21	FUS_26573619_Chip-Seq_HEK293_Human	1.69991649
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.57439069
23	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.55165333
24	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.52976985
25	RNF2_27304074_Chip-Seq_NSC_Mouse	1.52797844
26	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.51293187
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.48526482
28	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.48178602
29	ERA_21632823_ChIP-Seq_H3396_Human	1.48172043
30	VDR_23849224_ChIP-Seq_CD4+_Human	1.48048652
31	REST_21632747_ChIP-Seq_MESCs_Mouse	1.47705644
32	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.47379538
33	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.43082212
34	P300_19829295_ChIP-Seq_ESCs_Human	1.42938764
35	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.40661396
36	GATA1_22025678_ChIP-Seq_K562_Human	1.37299656
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.37211071
38	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.36718163
39	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.36662996
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.36568941
41	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.36457108
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36151773
43	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.34303047
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.27983039
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.27983039
46	EWS_26573619_Chip-Seq_HEK293_Human	1.27081662
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.22358176
48	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.22073125
49	TAF15_26573619_Chip-Seq_HEK293_Human	1.21786255
50	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.20584290
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.18503338
52	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18503338
53	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.17545299
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16703974
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16703974
56	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.15154706
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14046059
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.13585951
59	AR_25329375_ChIP-Seq_VCAP_Human	1.11836978
60	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.11462934
61	NCOR_22424771_ChIP-Seq_293T_Human	1.10092970
62	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.08826107
63	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.08782986
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.08086103
65	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.08054298
66	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.08010454
67	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.06345988
68	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05461072
69	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.04244509
70	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.03792072
71	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03223827
72	TCF4_23295773_ChIP-Seq_U87_Human	1.02890961
73	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.02693006
74	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.02447629
75	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01617750
76	AR_20517297_ChIP-Seq_VCAP_Human	1.00787189
77	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.00665471
78	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00083497
79	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.98882898
80	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.97521881
81	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.95996881
82	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.95834397
83	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.94436287
84	MYC_19829295_ChIP-Seq_ESCs_Human	0.94428226
85	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.94284890
86	RUNX2_22187159_ChIP-Seq_PCA_Human	0.93462398
87	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.92964464
88	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.91897087
89	HTT_18923047_ChIP-ChIP_STHdh_Human	0.91893360
90	HOXB7_26014856_ChIP-Seq_BT474_Human	0.90790392
91	SMAD4_21799915_ChIP-Seq_A2780_Human	0.90303064
92	DCP1A_22483619_ChIP-Seq_HELA_Human	0.89676606
93	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.89491237
94	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.89438052
95	ELK1_19687146_ChIP-ChIP_HELA_Human	0.88983484
96	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88909961
97	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.87680988
98	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.87121232
99	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.86890454
100	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.85453868

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	4.69168046
2	MP0005423_abnormal_somatic_nervous	3.76646018
3	MP0002822_catalepsy	3.36343677
4	MP0001984_abnormal_olfaction	2.77918231
5	MP0002736_abnormal_nociception_after	2.72082585
6	MP0008872_abnormal_physiological_respon	2.64745237
7	MP0005167_abnormal_blood-brain_barrier	2.63754830
8	MP0003880_abnormal_central_pattern	2.55656708
9	MP0002735_abnormal_chemical_nociception	2.51928679
10	MP0001968_abnormal_touch/_nociception	2.51885256
11	MP0005645_abnormal_hypothalamus_physiol	2.32488313
12	MP0002837_dystrophic_cardiac_calcinosis	2.31113807
13	MP0003646_muscle_fatigue	2.26278966
14	MP0001970_abnormal_pain_threshold	2.19319025
15	MP0005551_abnormal_eye_electrophysiolog	2.15833439
16	MP0004043_abnormal_pH_regulation	2.09728620
17	MP0002734_abnormal_mechanical_nocicepti	2.05503540
18	MP0003011_delayed_dark_adaptation	2.05031154
19	MP0004885_abnormal_endolymph	2.02549172
20	MP0002733_abnormal_thermal_nociception	1.99114171
21	MP0005377_hearing/vestibular/ear_phenot	1.97826499
22	MP0003878_abnormal_ear_physiology	1.97826499
23	MP0002272_abnormal_nervous_system	1.92620239
24	MP0006276_abnormal_autonomic_nervous	1.89712990
25	MP0008877_abnormal_DNA_methylation	1.88320022
26	MP0002653_abnormal_ependyma_morphology	1.75127325
27	MP0003195_calcinosis	1.72604085
28	MP0001486_abnormal_startle_reflex	1.71914661
29	MP0002638_abnormal_pupillary_reflex	1.70548531
30	MP0001348_abnormal_lacrimal_gland	1.69399246
31	MP0009745_abnormal_behavioral_response	1.61050440
32	MP0005253_abnormal_eye_physiology	1.59601213
33	MP0003137_abnormal_impulse_conducting	1.54630683
34	MP0005646_abnormal_pituitary_gland	1.52458619
35	MP0002102_abnormal_ear_morphology	1.49124416
36	MP0002572_abnormal_emotion/affect_behav	1.46316099
37	MP0004215_abnormal_myocardial_fiber	1.44244072
38	MP0008789_abnormal_olfactory_epithelium	1.44240709
39	MP0001501_abnormal_sleep_pattern	1.42688551
40	MP0001485_abnormal_pinna_reflex	1.41998132
41	MP0002063_abnormal_learning/memory/cond	1.39717257
42	MP0001905_abnormal_dopamine_level	1.38060405
43	MP0002557_abnormal_social/conspecific_i	1.27269165
44	MP0005310_abnormal_salivary_gland	1.22567554
45	MP0003329_amyloid_beta_deposits	1.21454029
46	MP0006072_abnormal_retinal_apoptosis	1.21344365
47	MP0001440_abnormal_grooming_behavior	1.20810120
48	MP0008875_abnormal_xenobiotic_pharmacok	1.19937575
49	MP0003635_abnormal_synaptic_transmissio	1.18478120
50	MP0005499_abnormal_olfactory_system	1.17605243
51	MP0005394_taste/olfaction_phenotype	1.17605243
52	MP0009785_altered_susceptibility_to	1.16426125
53	MP0004924_abnormal_behavior	1.07606411
54	MP0005386_behavior/neurological_phenoty	1.07606411
55	MP0000343_altered_response_to	1.05850718
56	MP0002138_abnormal_hepatobiliary_system	1.04726445
57	MP0005671_abnormal_response_to	1.04621474
58	MP0001529_abnormal_vocalization	1.03511845
59	MP0003787_abnormal_imprinting	1.03442953
60	MP0004084_abnormal_cardiac_muscle	1.02767409
61	MP0008775_abnormal_heart_ventricle	1.02582806
62	MP0003122_maternal_imprinting	1.02269293
63	MP0000230_abnormal_systemic_arterial	1.00294373
64	MP0001177_atelectasis	0.99798565
65	MP0003866_abnormal_defecation	0.96930188
66	MP0000569_abnormal_digit_pigmentation	0.96702189
67	MP0004133_heterotaxia	0.94985561
68	MP0009764_decreased_sensitivity_to	0.93964455
69	MP0003638_abnormal_response/metabolism_	0.93065052
70	MP0004142_abnormal_muscle_tone	0.91611098
71	MP0010329_abnormal_lipoprotein_level	0.88452507
72	MP0003436_decreased_susceptibility_to	0.88425163
73	MP0002067_abnormal_sensory_capabilities	0.86504750
74	MP0000604_amyloidosis	0.86045408
75	MP0002909_abnormal_adrenal_gland	0.84604446
76	MP0005195_abnormal_posterior_eye	0.83951213
77	MP0002148_abnormal_hypersensitivity_rea	0.80292043
78	MP0010386_abnormal_urinary_bladder	0.79968145
79	MP0002064_seizures	0.79666850
80	MP0002752_abnormal_somatic_nervous	0.74069574
81	MP0002229_neurodegeneration	0.73801880
82	MP0003724_increased_susceptibility_to	0.72850806
83	MP0005365_abnormal_bile_salt	0.72561983
84	MP0003183_abnormal_peptide_metabolism	0.71879315
85	MP0004130_abnormal_muscle_cell	0.70636487
86	MP0004085_abnormal_heartbeat	0.70608961
87	MP0002882_abnormal_neuron_morphology	0.69800673
88	MP0001765_abnormal_ion_homeostasis	0.68787679
89	MP0004145_abnormal_muscle_electrophysio	0.68786777
90	MP0000955_abnormal_spinal_cord	0.68515828
91	MP0004883_abnormal_blood_vessel	0.67580571
92	MP0001963_abnormal_hearing_physiology	0.67062957
93	MP0001919_abnormal_reproductive_system	0.64978139
94	MP0005636_abnormal_mineral_homeostasis	0.64778654
95	MP0001756_abnormal_urination	0.64401893
96	MP0006036_abnormal_mitochondrial_physio	0.63920478
97	MP0006292_abnormal_olfactory_placode	0.62806708
98	MP0009046_muscle_twitch	0.62652148
99	MP0002933_joint_inflammation	0.62146897
100	MP0004036_abnormal_muscle_relaxation	0.62145738

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Birth length less than 3rd percentile (HP:0003561)	7.18981884
2	Pancreatic cysts (HP:0001737)	4.47804679
3	Aplasia/Hypoplasia of the sternum (HP:0006714)	3.92351183
4	Breast hypoplasia (HP:0003187)	3.90938099
5	Pancreatic fibrosis (HP:0100732)	3.80261580
6	True hermaphroditism (HP:0010459)	3.78297333
7	Gait imbalance (HP:0002141)	3.73050560
8	Short tibia (HP:0005736)	3.68235754
9	Mitochondrial inheritance (HP:0001427)	3.67157272
10	Microretrognathia (HP:0000308)	3.62406368
11	Congenital primary aphakia (HP:0007707)	3.61851873
12	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.58650304
13	Medial flaring of the eyebrow (HP:0010747)	3.52463046
14	Acute necrotizing encephalopathy (HP:0006965)	3.49639320
15	Myokymia (HP:0002411)	3.44980296
16	Diastasis recti (HP:0001540)	3.41159324
17	Abnormality of midbrain morphology (HP:0002418)	3.39986650
18	Molar tooth sign on MRI (HP:0002419)	3.39986650
19	Renal cortical cysts (HP:0000803)	3.22351021
20	Nephrogenic diabetes insipidus (HP:0009806)	3.14682007
21	Patellar aplasia (HP:0006443)	3.11760308
22	Acute encephalopathy (HP:0006846)	3.10713543
23	Hyperventilation (HP:0002883)	3.05837127
24	Abnormal respiratory epithelium morphology (HP:0012253)	3.04254764
25	Abnormal respiratory motile cilium morphology (HP:0005938)	3.04254764
26	Abnormal mitochondria in muscle tissue (HP:0008316)	2.96085810
27	Congenital stationary night blindness (HP:0007642)	2.94761681
28	Abnormality of the renal cortex (HP:0011035)	2.91228085
29	Increased CSF lactate (HP:0002490)	2.89952482
30	Progressive macrocephaly (HP:0004481)	2.89346839
31	Stomach cancer (HP:0012126)	2.87871790
32	Aplasia/Hypoplasia of the patella (HP:0006498)	2.83120861
33	Abnormal ciliary motility (HP:0012262)	2.82144001
34	Hepatocellular necrosis (HP:0001404)	2.80108927
35	Hepatic necrosis (HP:0002605)	2.67831958
36	Supernumerary bones of the axial skeleton (HP:0009144)	2.65648323
37	Poor coordination (HP:0002370)	2.61703746
38	Genital tract atresia (HP:0001827)	2.58815149
39	Supernumerary ribs (HP:0005815)	2.57716066
40	Fibular hypoplasia (HP:0003038)	2.53451857
41	Retinal dysplasia (HP:0007973)	2.52182333
42	Increased hepatocellular lipid droplets (HP:0006565)	2.50354383
43	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.49071588
44	Type II lissencephaly (HP:0007260)	2.47624979
45	Vaginal atresia (HP:0000148)	2.46961210
46	Nasal speech (HP:0001611)	2.43363873
47	Poor speech (HP:0002465)	2.40686366
48	Nephronophthisis (HP:0000090)	2.39469453
49	Pendular nystagmus (HP:0012043)	2.38035552
50	Inability to walk (HP:0002540)	2.36364086
51	Optic disc pallor (HP:0000543)	2.34833556
52	Global brain atrophy (HP:0002283)	2.33734492
53	Anencephaly (HP:0002323)	2.31409446
54	Lipid accumulation in hepatocytes (HP:0006561)	2.25052666
55	Lissencephaly (HP:0001339)	2.22426373
56	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.20829912
57	Absent/shortened dynein arms (HP:0200106)	2.20829912
58	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.20576308
59	Broad-based gait (HP:0002136)	2.19740372
60	Cerebral edema (HP:0002181)	2.18019105
61	Sclerocornea (HP:0000647)	2.16377385
62	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.16247433
63	Absent thumb (HP:0009777)	2.11185518
64	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10426043
65	Cystic liver disease (HP:0006706)	2.09915820
66	Decreased central vision (HP:0007663)	2.08612004
67	Abnormal respiratory motile cilium physiology (HP:0012261)	2.08428842
68	Hypomagnesemia (HP:0002917)	2.08368824
69	Abolished electroretinogram (ERG) (HP:0000550)	2.04518812
70	Aplasia/Hypoplasia of the lens (HP:0008063)	2.03398272
71	Long foot (HP:0001833)	1.99130486
72	Respiratory failure (HP:0002878)	1.97551166
73	Optic nerve hypoplasia (HP:0000609)	1.95298036
74	Abnormality of the renal medulla (HP:0100957)	1.94244882
75	Type 2 muscle fiber atrophy (HP:0003554)	1.92371319
76	Furrowed tongue (HP:0000221)	1.91005761
77	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.90705344
78	Hypoplasia of the fovea (HP:0007750)	1.90705344
79	IgG deficiency (HP:0004315)	1.90375293
80	Renal Fanconi syndrome (HP:0001994)	1.90048208
81	Constricted visual fields (HP:0001133)	1.89887007
82	Postaxial foot polydactyly (HP:0001830)	1.89673826
83	Amelogenesis imperfecta (HP:0000705)	1.89323800
84	Increased intramyocellular lipid droplets (HP:0012240)	1.88067950
85	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.87776462
86	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.87776462
87	Poor head control (HP:0002421)	1.87028665
88	Male pseudohermaphroditism (HP:0000037)	1.86609385
89	Abnormality of magnesium homeostasis (HP:0004921)	1.84778008
90	Lactic acidosis (HP:0003128)	1.84455984
91	Genu varum (HP:0002970)	1.84336578
92	Scrotal hypoplasia (HP:0000046)	1.83546678
93	Supernumerary spleens (HP:0009799)	1.83056031
94	Attenuation of retinal blood vessels (HP:0007843)	1.79769194
95	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.79591269
96	Delayed CNS myelination (HP:0002188)	1.78880906
97	Abnormal rod and cone electroretinograms (HP:0008323)	1.76656728
98	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.75840804
99	Hypoplasia of the brainstem (HP:0002365)	1.75840804
100	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.75571844

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	6.35732253
2	TAOK3	4.95135022
3	ZAK	4.90389655
4	BMPR1B	4.81897875
5	ACVR1B	3.28659958
6	TGFBR1	2.73354016
7	DAPK2	2.29545733
8	MARK1	2.00755929
9	ADRBK2	1.91758125
10	WNK3	1.75517618
11	RPS6KA4	1.63628711
12	STK16	1.54040160
13	CAMKK1	1.53573308
14	MST4	1.52209415
15	SIK2	1.46100535
16	NTRK2	1.45762192
17	MELK	1.42919994
18	GRK5	1.42856989
19	TRIM28	1.39822649
20	GRK6	1.37369738
21	NEK9	1.34105294
22	TLK1	1.29241345
23	CDK8	1.25133113
24	GRK1	1.24806764
25	MAPK13	1.21685713
26	LIMK1	1.21458501
27	KDR	1.20594634
28	MAP2K2	1.15504077
29	SRPK1	1.12144453
30	MKNK2	1.09352552
31	GRK7	1.08017462
32	FRK	1.07509114
33	WNK4	1.06511132
34	CAMKK2	1.05280710
35	MAP3K4	1.02362743
36	DYRK2	0.98123972
37	MAP2K7	0.96111884
38	TXK	0.95435896
39	INSRR	0.87573973
40	NUAK1	0.84512048
41	TIE1	0.80999785
42	NME1	0.80483315
43	MAPKAPK3	0.80163889
44	BCR	0.79443050
45	CAMK1	0.77784518
46	CAMK4	0.77189140
47	ADRBK1	0.76648287
48	CSNK1G3	0.76433063
49	PNCK	0.73565848
50	CSNK1G2	0.69668944
51	PAK3	0.67027103
52	MAP3K7	0.64590642
53	CSNK1A1L	0.63688173
54	BCKDK	0.60989877
55	ERBB3	0.60727908
56	EIF2AK2	0.60496288
57	PHKG2	0.59972439
58	PHKG1	0.59972439
59	PKN1	0.59069288
60	ITK	0.58227591
61	CAMK2A	0.57895981
62	RPS6KA5	0.57302426
63	MAP2K1	0.56572830
64	CSNK1G1	0.56124193
65	PIM1	0.55037244
66	PRKCE	0.52600127
67	SYK	0.52156405
68	EPHA3	0.51206405
69	MAP3K14	0.50149676
70	CSNK1A1	0.48474207
71	ALK	0.47984448
72	MKNK1	0.47458138
73	STK38	0.46612509
74	PLK3	0.46090692
75	PRKCG	0.45321913
76	TEC	0.44809092
77	CHUK	0.40377970
78	IKBKB	0.40316571
79	VRK1	0.39490941
80	BUB1	0.38811121
81	ABL2	0.37690885
82	MAP2K6	0.35423665
83	DAPK1	0.34236679
84	MAP4K2	0.34028196
85	PRKCQ	0.33948502
86	PIK3CA	0.33754616
87	CAMK2D	0.32320115
88	CAMK1G	0.31532673
89	IGF1R	0.31231936
90	NEK1	0.31042728
91	TNK2	0.27420080
92	STK38L	0.26139675
93	PRKACA	0.23988863
94	OXSR1	0.22490310
95	LYN	0.22003232
96	LCK	0.21754992
97	OBSCN	0.20740214
98	PTK2B	0.20468625
99	PINK1	0.19874019
100	PRKACG	0.19164446

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.76146164
2	Parkinsons disease_Homo sapiens_hsa05012	3.16972671
3	RNA polymerase_Homo sapiens_hsa03020	2.95919100
4	Protein export_Homo sapiens_hsa03060	2.64753310
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.60426797
6	Alzheimers disease_Homo sapiens_hsa05010	2.36811727
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.14885067
8	Huntingtons disease_Homo sapiens_hsa05016	2.13954937
9	Nicotine addiction_Homo sapiens_hsa05033	2.09627860
10	Proteasome_Homo sapiens_hsa03050	2.02441372
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.99963145
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.97132641
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.86865784
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.83430980
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.78603225
16	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.77614777
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.73021701
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.57996713
19	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.54829691
20	Morphine addiction_Homo sapiens_hsa05032	1.52389256
21	Butanoate metabolism_Homo sapiens_hsa00650	1.45648552
22	GABAergic synapse_Homo sapiens_hsa04727	1.43783605
23	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.31140971
24	Caffeine metabolism_Homo sapiens_hsa00232	1.29925564
25	Propanoate metabolism_Homo sapiens_hsa00640	1.29797856
26	Primary immunodeficiency_Homo sapiens_hsa05340	1.29410533
27	Collecting duct acid secretion_Homo sapiens_hsa04966	1.29270432
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.24313346
29	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.22244635
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.21970336
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.21201580
32	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.18423408
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.17043236
34	Phototransduction_Homo sapiens_hsa04744	1.16366579
35	Retinol metabolism_Homo sapiens_hsa00830	1.16286919
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.14593062
37	Graft-versus-host disease_Homo sapiens_hsa05332	1.12690652
38	Serotonergic synapse_Homo sapiens_hsa04726	1.11708211
39	Fatty acid elongation_Homo sapiens_hsa00062	1.08574863
40	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.08532052
41	Rheumatoid arthritis_Homo sapiens_hsa05323	1.08146938
42	RNA degradation_Homo sapiens_hsa03018	0.99723458
43	beta-Alanine metabolism_Homo sapiens_hsa00410	0.98095783
44	Ether lipid metabolism_Homo sapiens_hsa00565	0.95829758
45	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.95620460
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.94853033
47	Peroxisome_Homo sapiens_hsa04146	0.94071821
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.93018758
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.91972398
50	Glycerolipid metabolism_Homo sapiens_hsa00561	0.89758910
51	Sulfur relay system_Homo sapiens_hsa04122	0.88467145
52	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.88006195
53	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.87960779
54	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.86983981
55	Sulfur metabolism_Homo sapiens_hsa00920	0.85523174
56	Circadian entrainment_Homo sapiens_hsa04713	0.82988387
57	Purine metabolism_Homo sapiens_hsa00230	0.82623907
58	ABC transporters_Homo sapiens_hsa02010	0.80939380
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.77013755
60	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.75706036
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.75669857
62	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.75049526
63	Salivary secretion_Homo sapiens_hsa04970	0.74331709
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.73821117
65	Pancreatic secretion_Homo sapiens_hsa04972	0.73109893
66	Insulin secretion_Homo sapiens_hsa04911	0.71103030
67	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.70656873
68	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.70222159
69	Mineral absorption_Homo sapiens_hsa04978	0.69368066
70	Taste transduction_Homo sapiens_hsa04742	0.67719170
71	Metabolic pathways_Homo sapiens_hsa01100	0.64034470
72	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.63013793
73	Allograft rejection_Homo sapiens_hsa05330	0.61275296
74	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.61202513
75	One carbon pool by folate_Homo sapiens_hsa00670	0.60711302
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.59460619
77	Mismatch repair_Homo sapiens_hsa03430	0.59304978
78	Bile secretion_Homo sapiens_hsa04976	0.58575176
79	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.58187412
80	Tyrosine metabolism_Homo sapiens_hsa00350	0.56689638
81	Histidine metabolism_Homo sapiens_hsa00340	0.55700271
82	DNA replication_Homo sapiens_hsa03030	0.55472939
83	Glutamatergic synapse_Homo sapiens_hsa04724	0.54731634
84	Arginine and proline metabolism_Homo sapiens_hsa00330	0.54400747
85	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.53058205
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.53016542
87	Nucleotide excision repair_Homo sapiens_hsa03420	0.50593830
88	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.49664948
89	Gastric acid secretion_Homo sapiens_hsa04971	0.46477150
90	Olfactory transduction_Homo sapiens_hsa04740	0.43371668
91	Selenocompound metabolism_Homo sapiens_hsa00450	0.43113091
92	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.41455218
93	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.39521182
94	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.38408032
95	Type I diabetes mellitus_Homo sapiens_hsa04940	0.38251670
96	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.36480632
97	Ribosome_Homo sapiens_hsa03010	0.35835636
98	cAMP signaling pathway_Homo sapiens_hsa04024	0.31646245
99	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.31385217
100	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.30284826

PSMC1P12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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