PSMC1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.76618165
2cytidine metabolic process (GO:0046087)6.23285319
3cytidine catabolic process (GO:0006216)6.23285319
4cytidine deamination (GO:0009972)6.23285319
5pyrimidine ribonucleoside catabolic process (GO:0046133)5.43175061
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.21427901
7positive regulation of interleukin-8 secretion (GO:2000484)4.29115548
8regulation of cellular amino acid metabolic process (GO:0006521)4.14765777
9negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.10779038
10regulation of regulatory T cell differentiation (GO:0045589)4.08535905
11sequestering of actin monomers (GO:0042989)3.90178447
12DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.87897789
13proteasome assembly (GO:0043248)3.85689111
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.83523993
15regulation of interleukin-8 secretion (GO:2000482)3.78244496
16signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.78099427
17signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.78099427
18signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.78099427
19regulation of chronic inflammatory response (GO:0002676)3.77597302
20negative regulation of T cell apoptotic process (GO:0070233)3.76778417
21intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.75206512
22signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.75206512
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.73201519
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.73201519
25positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.68414350
26negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.66683375
27negative regulation of ligase activity (GO:0051352)3.66683375
28signal transduction involved in DNA damage checkpoint (GO:0072422)3.57916973
29signal transduction involved in DNA integrity checkpoint (GO:0072401)3.57916973
30iron-sulfur cluster assembly (GO:0016226)3.56868049
31metallo-sulfur cluster assembly (GO:0031163)3.56868049
32antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.56633759
33positive thymic T cell selection (GO:0045059)3.54396797
34signal transduction involved in cell cycle checkpoint (GO:0072395)3.52775293
35Arp2/3 complex-mediated actin nucleation (GO:0034314)3.51029866
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.49257512
37negative regulation by host of viral transcription (GO:0043922)3.48951595
38L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.45429900
39positive regulation of prostaglandin secretion (GO:0032308)3.40638514
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.37328346
41positive regulation of calcium-mediated signaling (GO:0050850)3.36709902
42mast cell activation involved in immune response (GO:0002279)3.36375410
43mast cell degranulation (GO:0043303)3.36375410
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.31924583
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.31311230
46ATP synthesis coupled proton transport (GO:0015986)3.29823111
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.29823111
48positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.26592427
49positive T cell selection (GO:0043368)3.26288228
50mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.26009057
51RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.25377767
52eosinophil chemotaxis (GO:0048245)3.24933078
53rRNA modification (GO:0000154)3.21919210
54positive regulation of T cell mediated cytotoxicity (GO:0001916)3.21278213
55anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.20485009
56regulation of T cell mediated cytotoxicity (GO:0001914)3.19660497
57actin nucleation (GO:0045010)3.15334473
58positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.10810328
59positive regulation of cell cycle arrest (GO:0071158)3.10767129
60antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.07049206
61regulation of leukocyte mediated cytotoxicity (GO:0001910)3.05017668
62positive regulation of ligase activity (GO:0051351)3.04277395
63T cell migration (GO:0072678)3.02434507
64positive regulation of natural killer cell mediated immunity (GO:0002717)3.00154696
65positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.99836376
66mannosylation (GO:0097502)2.99235815
67negative regulation of lymphocyte apoptotic process (GO:0070229)2.97636273
68L-methionine salvage (GO:0071267)2.97628908
69L-methionine biosynthetic process (GO:0071265)2.97628908
70amino acid salvage (GO:0043102)2.97628908
71respiratory electron transport chain (GO:0022904)2.96113870
72electron transport chain (GO:0022900)2.94643616
73DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.93832367
74eosinophil migration (GO:0072677)2.92963363
75regulation of cellular amine metabolic process (GO:0033238)2.91530580
76negative regulation of viral genome replication (GO:0045071)2.88234334
77termination of RNA polymerase III transcription (GO:0006386)2.86146221
78transcription elongation from RNA polymerase III promoter (GO:0006385)2.86146221
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83524383
80response to interferon-beta (GO:0035456)2.82763566
81adenosine metabolic process (GO:0046085)2.80941988
82deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.80805742
83DNA dealkylation (GO:0035510)2.80693235
84respiratory chain complex IV assembly (GO:0008535)2.77990064
85mitochondrial respiratory chain complex I assembly (GO:0032981)2.77772451
86NADH dehydrogenase complex assembly (GO:0010257)2.77772451
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.77772451
88regulation of T cell apoptotic process (GO:0070232)2.76529264
89mast cell activation (GO:0045576)2.74963931
90positive regulation of tolerance induction (GO:0002645)2.74575499
91cytolysis (GO:0019835)2.74297883
92regulation of calcium-mediated signaling (GO:0050848)2.73076018
93nucleotide transmembrane transport (GO:1901679)2.71646502
94positive regulation of uterine smooth muscle contraction (GO:0070474)2.71570442
95regulation of activation of Janus kinase activity (GO:0010533)2.71177562
96protein complex biogenesis (GO:0070271)2.71095549
97cellular response to interleukin-15 (GO:0071350)2.69990347
98pyrimidine nucleoside catabolic process (GO:0046135)2.69612960
99positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.66962934
100positive regulation of cell killing (GO:0031343)2.66058943

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.57940290
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.30121090
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.99464130
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.76631925
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.73781967
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.37967627
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.12801126
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.12057946
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.10570042
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.90930380
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.78532933
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.67368783
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.61315685
14VDR_23849224_ChIP-Seq_CD4+_Human2.45687947
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31475163
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.23350519
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11083829
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05732767
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.01447727
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.00390805
21IRF8_21731497_ChIP-ChIP_J774_Mouse1.95353781
22FOXP3_21729870_ChIP-Seq_TREG_Human1.90353580
23ELK1_19687146_ChIP-ChIP_HELA_Human1.86385083
24VDR_22108803_ChIP-Seq_LS180_Human1.83726933
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.80784469
26GATA3_26560356_Chip-Seq_TH2_Human1.76300844
27HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76001803
28MYB_26560356_Chip-Seq_TH2_Human1.75112040
29ZNF274_21170338_ChIP-Seq_K562_Hela1.69546311
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69468098
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69147082
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.67071269
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65701489
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61574140
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61088596
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.59801561
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58912712
38GATA3_27048872_Chip-Seq_THYMUS_Human1.58185869
39MYC_18940864_ChIP-ChIP_HL60_Human1.47258780
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46624313
41AR_20517297_ChIP-Seq_VCAP_Human1.42463236
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42341685
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42281741
44RUNX_20019798_ChIP-Seq_JUKART_Human1.40132605
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40080155
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39534255
47DCP1A_22483619_ChIP-Seq_HELA_Human1.38597351
48CIITA_25753668_ChIP-Seq_RAJI_Human1.36166898
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35987253
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32976074
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30028728
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26934043
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22687429
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.22687429
55PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20994154
56TAF15_26573619_Chip-Seq_HEK293_Human1.20359781
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.19672208
58RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.17811144
59TP53_22573176_ChIP-Seq_HFKS_Human1.17717771
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16299637
61GATA1_22025678_ChIP-Seq_K562_Human1.14764435
62FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13624154
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13598566
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13499685
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13323321
66TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.12624402
67EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11909340
68SPI1_23547873_ChIP-Seq_NB4_Human1.11635022
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08861897
70EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07580702
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07030367
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05294031
73MYB_26560356_Chip-Seq_TH1_Human1.03549595
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03083931
75TAF2_19829295_ChIP-Seq_ESCs_Human1.02247851
76GABP_19822575_ChIP-Seq_HepG2_Human1.01553316
77FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99252067
78GATA3_26560356_Chip-Seq_TH1_Human0.98297624
79EZH2_27294783_Chip-Seq_NPCs_Mouse0.98266972
80ER_23166858_ChIP-Seq_MCF-7_Human0.97497968
81GATA3_21878914_ChIP-Seq_MCF-7_Human0.97466723
82PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97016340
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.95579081
84ELK1_22589737_ChIP-Seq_MCF10A_Human0.95110594
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93766696
86SOX2_19829295_ChIP-Seq_ESCs_Human0.93553967
87NANOG_19829295_ChIP-Seq_ESCs_Human0.93553967
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92212529
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92192797
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.91213858
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.90852027
92STAT1_20625510_ChIP-Seq_HELA_Human0.87700186
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87315336
94E2F1_18555785_ChIP-Seq_MESCs_Mouse0.86459595
95MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.85863171
96SALL4_22934838_ChIP-ChIP_CD34+_Human0.85669616
97STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.85108801
98MYC_19030024_ChIP-ChIP_MESCs_Mouse0.83405067
99CRX_20693478_ChIP-Seq_RETINA_Mouse0.83243940
100NANOG_20526341_ChIP-Seq_ESCs_Human0.82606263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.49500948
2MP0002138_abnormal_hepatobiliary_system3.83054567
3MP0002102_abnormal_ear_morphology3.68026714
4MP0009785_altered_susceptibility_to2.82497445
5MP0003878_abnormal_ear_physiology2.71384977
6MP0005377_hearing/vestibular/ear_phenot2.71384977
7MP0001835_abnormal_antigen_presentation2.53855670
8MP0002148_abnormal_hypersensitivity_rea2.37526432
9MP0000372_irregular_coat_pigmentation2.35378520
10MP0005000_abnormal_immune_tolerance2.19838249
11MP0009333_abnormal_splenocyte_physiolog2.18299845
12MP0006082_CNS_inflammation2.16092270
13MP0004147_increased_porphyrin_level2.14375586
14MP0001800_abnormal_humoral_immune2.14107703
15MP0003763_abnormal_thymus_physiology2.11198861
16MP0003011_delayed_dark_adaptation1.97684536
17MP0002723_abnormal_immune_serum1.96248518
18MP0003786_premature_aging1.91891659
19MP0001790_abnormal_immune_system1.88035871
20MP0005387_immune_system_phenotype1.88035871
21MP0003866_abnormal_defecation1.85394197
22MP0002420_abnormal_adaptive_immunity1.84629479
23MP0001485_abnormal_pinna_reflex1.81895525
24MP0001819_abnormal_immune_cell1.81165305
25MP0004145_abnormal_muscle_electrophysio1.79510330
26MP0005075_abnormal_melanosome_morpholog1.68856409
27MP0000685_abnormal_immune_system1.65219613
28MP0001905_abnormal_dopamine_level1.64293119
29MP0003436_decreased_susceptibility_to1.61324432
30MP0005464_abnormal_platelet_physiology1.61317017
31MP0002452_abnormal_antigen_presenting1.60645464
32MP0002006_tumorigenesis1.60168105
33MP0003806_abnormal_nucleotide_metabolis1.58058737
34MP0006072_abnormal_retinal_apoptosis1.56002945
35MP0005025_abnormal_response_to1.54246468
36MP0002166_altered_tumor_susceptibility1.50246073
37MP0003045_fibrosis1.47445513
38MP0002405_respiratory_system_inflammati1.43821657
39MP0002933_joint_inflammation1.43632661
40MP0006036_abnormal_mitochondrial_physio1.41528625
41MP0002398_abnormal_bone_marrow1.41522966
42MP0000716_abnormal_immune_system1.39960256
43MP0003724_increased_susceptibility_to1.39503780
44MP0006035_abnormal_mitochondrial_morpho1.38840529
45MP0008058_abnormal_DNA_repair1.36379220
46MP0000689_abnormal_spleen_morphology1.28075220
47MP0001968_abnormal_touch/_nociception1.21508938
48MP0008872_abnormal_physiological_respon1.21186494
49MP0010155_abnormal_intestine_physiology1.18548107
50MP0005551_abnormal_eye_electrophysiolog1.17231153
51MP0001845_abnormal_inflammatory_respons1.16991504
52MP0001853_heart_inflammation1.13444917
53MP0001501_abnormal_sleep_pattern1.12086387
54MP0002429_abnormal_blood_cell1.11659087
55MP0002722_abnormal_immune_system1.10831344
56MP0002837_dystrophic_cardiac_calcinosis1.08703362
57MP0002876_abnormal_thyroid_physiology1.05459641
58MP0009764_decreased_sensitivity_to1.05073000
59MP0005645_abnormal_hypothalamus_physiol1.03875801
60MP0001919_abnormal_reproductive_system1.02663154
61MP0000703_abnormal_thymus_morphology1.02320515
62MP0002733_abnormal_thermal_nociception1.01871535
63MP0008877_abnormal_DNA_methylation1.01729962
64MP0005379_endocrine/exocrine_gland_phen1.00454719
65MP0005084_abnormal_gallbladder_morpholo0.98538777
66MP0000569_abnormal_digit_pigmentation0.96611245
67MP0005085_abnormal_gallbladder_physiolo0.95487217
68MP0003567_abnormal_fetal_cardiomyocyte0.94215150
69MP0002419_abnormal_innate_immunity0.94068957
70MP0004957_abnormal_blastocyst_morpholog0.93777907
71MP0003646_muscle_fatigue0.93421600
72MP0001661_extended_life_span0.92528096
73MP0008875_abnormal_xenobiotic_pharmacok0.92508411
74MP0008469_abnormal_protein_level0.91582999
75MP0006276_abnormal_autonomic_nervous0.91395373
76MP0005253_abnormal_eye_physiology0.90894287
77MP0003448_altered_tumor_morphology0.89037847
78MP0001881_abnormal_mammary_gland0.88728090
79MP0003137_abnormal_impulse_conducting0.87348648
80MP0003172_abnormal_lysosome_physiology0.87167464
81MP0009763_increased_sensitivity_to0.85385406
82MP0000230_abnormal_systemic_arterial0.83443050
83MP0003252_abnormal_bile_duct0.81978353
84MP0003693_abnormal_embryo_hatching0.81880219
85MP0005167_abnormal_blood-brain_barrier0.81390468
86MP0002163_abnormal_gland_morphology0.78031185
87MP0002019_abnormal_tumor_incidence0.77729071
88MP0009643_abnormal_urine_homeostasis0.77633155
89MP0000613_abnormal_salivary_gland0.76672742
90MP0008873_increased_physiological_sensi0.76301729
91MP0005636_abnormal_mineral_homeostasis0.75184422
92MP0005389_reproductive_system_phenotype0.74534415
93MP0003195_calcinosis0.73870583
94MP0001764_abnormal_homeostasis0.72634398
95MP0001873_stomach_inflammation0.71697730
96MP0002736_abnormal_nociception_after0.71589308
97MP0004142_abnormal_muscle_tone0.69742523
98MP0001970_abnormal_pain_threshold0.69343027
99MP0003638_abnormal_response/metabolism_0.69251205
100MP0005646_abnormal_pituitary_gland0.69097953

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.07631247
2Abnormality of alanine metabolism (HP:0010916)4.00784703
3Hyperalaninemia (HP:0003348)4.00784703
4Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.00784703
5Aplastic anemia (HP:0001915)3.95915460
6IgG deficiency (HP:0004315)3.93602610
7Severe combined immunodeficiency (HP:0004430)3.92583228
8Hypoproteinemia (HP:0003075)3.92135532
9Acute necrotizing encephalopathy (HP:0006965)3.86492520
10Abnormality of T cell number (HP:0011839)3.84950403
11Mitochondrial inheritance (HP:0001427)3.77372381
12Abnormal mitochondria in muscle tissue (HP:0008316)3.76885550
13Molar tooth sign on MRI (HP:0002419)3.62336758
14Abnormality of midbrain morphology (HP:0002418)3.62336758
15Hepatocellular necrosis (HP:0001404)3.55323291
16Absent rod-and cone-mediated responses on ERG (HP:0007688)3.53141466
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.48349718
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.48349718
19Stomatitis (HP:0010280)3.47844125
20Increased CSF lactate (HP:0002490)3.37369039
21Hepatic necrosis (HP:0002605)3.35111754
22Acute encephalopathy (HP:0006846)3.29871462
233-Methylglutaconic aciduria (HP:0003535)3.13200694
24Cerebral edema (HP:0002181)3.12714833
25Progressive macrocephaly (HP:0004481)3.09596623
26Abnormality of T cells (HP:0002843)3.02929826
27Combined immunodeficiency (HP:0005387)2.99866106
28Increased intramyocellular lipid droplets (HP:0012240)2.99394739
29Agammaglobulinemia (HP:0004432)2.82858237
30Decreased central vision (HP:0007663)2.82482878
31Thyroiditis (HP:0100646)2.79427049
32Generalized aminoaciduria (HP:0002909)2.72463331
33Type I transferrin isoform profile (HP:0003642)2.71448234
34Abnormality of eosinophils (HP:0001879)2.68323559
35Increased serum lactate (HP:0002151)2.66867651
36Pancreatic cysts (HP:0001737)2.65632527
37Abnormality of the prostate (HP:0008775)2.65442336
38Abolished electroretinogram (ERG) (HP:0000550)2.61357255
39Abnormal rod and cone electroretinograms (HP:0008323)2.55143312
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.54995930
41Lactic acidosis (HP:0003128)2.54131983
42Increased muscle lipid content (HP:0009058)2.51092096
43Retinal dysplasia (HP:0007973)2.47848250
44Elevated erythrocyte sedimentation rate (HP:0003565)2.43495911
45Renal cortical cysts (HP:0000803)2.42038807
46Hypoalbuminemia (HP:0003073)2.36984136
47Abnormal albumin level (HP:0012116)2.36984136
48Bifid tongue (HP:0010297)2.36348050
49Increased hepatocellular lipid droplets (HP:0006565)2.35900392
50Eosinophilia (HP:0001880)2.35465789
51Abnormal protein glycosylation (HP:0012346)2.34755664
52Abnormal glycosylation (HP:0012345)2.34755664
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.34755664
54Abnormal protein N-linked glycosylation (HP:0012347)2.34755664
55Abnormality of T cell physiology (HP:0011840)2.32519211
56Tongue fasciculations (HP:0001308)2.32206416
57Panhypogammaglobulinemia (HP:0003139)2.30949926
58Lipid accumulation in hepatocytes (HP:0006561)2.25202677
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.21215390
60Nephronophthisis (HP:0000090)2.17895762
61Abnormality of serum amino acid levels (HP:0003112)2.17432117
62Optic disc pallor (HP:0000543)2.10480397
63CNS demyelination (HP:0007305)2.09374542
64Renal Fanconi syndrome (HP:0001994)2.08671340
65Increased IgM level (HP:0003496)2.07944761
66Meningitis (HP:0001287)2.07846623
67Granulocytopenia (HP:0001913)2.07751032
68Respiratory failure (HP:0002878)2.07273895
69Hypothermia (HP:0002045)2.06981178
70Pancreatic fibrosis (HP:0100732)2.05561098
71Abnormality of the renal cortex (HP:0011035)2.04632016
72IgM deficiency (HP:0002850)2.03757129
73Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.03536696
74Attenuation of retinal blood vessels (HP:0007843)2.03422403
75Recurrent corneal erosions (HP:0000495)2.02568074
76Pustule (HP:0200039)2.02429499
77Cerebral hypomyelination (HP:0006808)2.01020656
78True hermaphroditism (HP:0010459)1.99714090
79Spastic paraparesis (HP:0002313)1.98329163
80Encephalitis (HP:0002383)1.95895042
81Constricted visual fields (HP:0001133)1.95589957
82Reduced antithrombin III activity (HP:0001976)1.93171735
83Abnormality of the anterior horn cell (HP:0006802)1.92180564
84Degeneration of anterior horn cells (HP:0002398)1.92180564
85Type 2 muscle fiber atrophy (HP:0003554)1.92172159
86Exercise intolerance (HP:0003546)1.91550639
87Lethargy (HP:0001254)1.91290404
88Muscle fibrillation (HP:0010546)1.90420106
89Congenital stationary night blindness (HP:0007642)1.89288300
90Pancytopenia (HP:0001876)1.88485440
91Pulmonary fibrosis (HP:0002206)1.87091025
92Nausea (HP:0002018)1.85914699
93Autoamputation (HP:0001218)1.85657583
94Autoimmune hemolytic anemia (HP:0001890)1.84227792
95Microretrognathia (HP:0000308)1.83443603
96Recurrent bronchitis (HP:0002837)1.83402962
97Abnormality of B cell number (HP:0010975)1.82593482
98Leukocytosis (HP:0001974)1.81928366
99Emotional lability (HP:0000712)1.81027012
100Prostate neoplasm (HP:0100787)1.76184369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.21875788
2KDR4.09516060
3BCKDK3.24692380
4BMPR1B3.18324078
5MAP3K122.94540998
6TESK22.73958035
7VRK22.64736349
8BUB12.53672045
9MAP4K12.28003357
10ADRBK22.24416560
11MAPKAPK32.21353113
12ZAK2.10733495
13TRIM282.05482305
14ITK2.02816066
15TIE12.01296632
16SRPK11.95787332
17TAOK31.95435378
18TLK11.91509176
19TEC1.75938695
20STK161.73924021
21SCYL21.67906545
22PDK21.54364310
23VRK11.54165688
24MST41.45651751
25NUAK11.45598129
26MYLK1.44336091
27DAPK11.43164555
28SYK1.34497393
29GRK11.28857346
30FES1.28170657
31LIMK11.27872284
32ERBB31.26858086
33CSNK1G31.24811252
34MAP4K21.13365137
35ZAP701.13287645
36CDK81.09212781
37GRK61.08485980
38RPS6KA41.07088130
39BCR1.07051273
40EIF2AK31.03172010
41CSNK1G20.92772026
42KIT0.92348658
43TGFBR10.92113766
44TSSK60.90312297
45TESK10.89149721
46LCK0.88676788
47PIK3CG0.88143190
48CSNK1A1L0.85507107
49FRK0.85447045
50CSNK1G10.85046724
51PINK10.83780658
52BTK0.83764100
53CSF1R0.81588791
54MAP3K110.78325663
55PRKCQ0.77928689
56TRPM70.77249310
57INSRR0.74135131
58GRK70.72636932
59PLK30.72168561
60LYN0.69871058
61MATK0.68478456
62RPS6KA50.64839685
63MAP2K60.63674567
64JAK30.62707353
65PLK20.60446963
66IGF1R0.58440720
67NME10.57333439
68CSK0.53872853
69CSNK1A10.53790416
70HCK0.48557186
71IKBKB0.47823640
72SIK30.47333337
73IKBKE0.45495001
74PRKCE0.44176148
75PIK3CA0.41386320
76PIM10.39494334
77MINK10.39146204
78PHKG20.38289236
79PHKG10.38289236
80MAP3K50.38142652
81MAPK130.37792048
82WNK30.37735957
83ABL10.37411694
84ATR0.36765343
85ADRBK10.36066440
86PRKCA0.36024091
87CAMK2A0.34738834
88CSNK2A10.34667399
89OBSCN0.34303255
90OXSR10.34180031
91ALK0.32829159
92DAPK30.32640675
93PTK2B0.32524812
94RIPK40.32514759
95NTRK10.30910203
96FLT30.29894925
97EIF2AK10.29236490
98BLK0.28032594
99PRKACA0.26949974
100ROCK10.26902640

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.38346023
2Primary immunodeficiency_Homo sapiens_hsa053404.47723036
3Graft-versus-host disease_Homo sapiens_hsa053323.23127890
4Autoimmune thyroid disease_Homo sapiens_hsa053202.90435342
5Oxidative phosphorylation_Homo sapiens_hsa001902.87129670
6Allograft rejection_Homo sapiens_hsa053302.82984198
7Parkinsons disease_Homo sapiens_hsa050122.47925852
8Antigen processing and presentation_Homo sapiens_hsa046122.47152708
9Type I diabetes mellitus_Homo sapiens_hsa049402.39889628
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09823110
11RNA polymerase_Homo sapiens_hsa030202.07818536
12Protein export_Homo sapiens_hsa030602.00319213
13Sulfur metabolism_Homo sapiens_hsa009201.97876396
14Hematopoietic cell lineage_Homo sapiens_hsa046401.95223237
15Asthma_Homo sapiens_hsa053101.93475504
16Rheumatoid arthritis_Homo sapiens_hsa053231.74711862
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.58131833
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43695744
19Mismatch repair_Homo sapiens_hsa034301.43359262
20Alzheimers disease_Homo sapiens_hsa050101.42048349
21Base excision repair_Homo sapiens_hsa034101.41801238
22Huntingtons disease_Homo sapiens_hsa050161.40920279
23Peroxisome_Homo sapiens_hsa041461.30964681
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26270181
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.25601949
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24872610
27DNA replication_Homo sapiens_hsa030301.24112516
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18210923
29One carbon pool by folate_Homo sapiens_hsa006701.12877106
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10237643
31Pyrimidine metabolism_Homo sapiens_hsa002401.09513303
32Homologous recombination_Homo sapiens_hsa034401.08563005
33RNA degradation_Homo sapiens_hsa030181.07686844
34Phototransduction_Homo sapiens_hsa047441.03104129
35Non-homologous end-joining_Homo sapiens_hsa034501.02786636
36Purine metabolism_Homo sapiens_hsa002301.02558407
37Viral myocarditis_Homo sapiens_hsa054161.00274353
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99200009
39Basal transcription factors_Homo sapiens_hsa030220.98523677
40Selenocompound metabolism_Homo sapiens_hsa004500.96296574
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95845603
42Nucleotide excision repair_Homo sapiens_hsa034200.95653714
43T cell receptor signaling pathway_Homo sapiens_hsa046600.94711447
44Ribosome_Homo sapiens_hsa030100.94491088
45Cardiac muscle contraction_Homo sapiens_hsa042600.93952069
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91422185
47Butanoate metabolism_Homo sapiens_hsa006500.90374385
48Propanoate metabolism_Homo sapiens_hsa006400.89541044
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88445169
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87669022
51Caffeine metabolism_Homo sapiens_hsa002320.87028647
52Spliceosome_Homo sapiens_hsa030400.86816945
53Retinol metabolism_Homo sapiens_hsa008300.85550106
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.83970388
55Fatty acid elongation_Homo sapiens_hsa000620.83716088
56Collecting duct acid secretion_Homo sapiens_hsa049660.80245339
57Systemic lupus erythematosus_Homo sapiens_hsa053220.76618516
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73990413
59Nitrogen metabolism_Homo sapiens_hsa009100.72931931
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72615313
61Chemical carcinogenesis_Homo sapiens_hsa052040.70138565
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.66196343
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64084289
64Linoleic acid metabolism_Homo sapiens_hsa005910.63306907
65Epstein-Barr virus infection_Homo sapiens_hsa051690.62467583
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60355977
67Herpes simplex infection_Homo sapiens_hsa051680.60019604
68RNA transport_Homo sapiens_hsa030130.59731985
69Measles_Homo sapiens_hsa051620.59690888
70Salmonella infection_Homo sapiens_hsa051320.55513215
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55143039
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54122947
73Fanconi anemia pathway_Homo sapiens_hsa034600.53565442
74Renin-angiotensin system_Homo sapiens_hsa046140.52125932
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49516557
76Tryptophan metabolism_Homo sapiens_hsa003800.49387499
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.48124843
78Arachidonic acid metabolism_Homo sapiens_hsa005900.47570152
79Staphylococcus aureus infection_Homo sapiens_hsa051500.47434169
80Metabolic pathways_Homo sapiens_hsa011000.47401447
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46223307
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46008902
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45811450
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42714967
85Shigellosis_Homo sapiens_hsa051310.42157744
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.41237843
87Glutathione metabolism_Homo sapiens_hsa004800.39028864
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.36952248
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33270356
90N-Glycan biosynthesis_Homo sapiens_hsa005100.32202538
91Olfactory transduction_Homo sapiens_hsa047400.28675150
92Fatty acid metabolism_Homo sapiens_hsa012120.28168703
93Fatty acid degradation_Homo sapiens_hsa000710.28110577
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27944174
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26473979
96Taste transduction_Homo sapiens_hsa047420.26368151
97Fat digestion and absorption_Homo sapiens_hsa049750.26279344
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24368328
99Regulation of autophagy_Homo sapiens_hsa041400.24050736
100Malaria_Homo sapiens_hsa051440.24018481

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