

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 6.76618165 |
| 2 | cytidine deamination (GO:0009972) | 6.23285319 |
| 3 | cytidine metabolic process (GO:0046087) | 6.23285319 |
| 4 | cytidine catabolic process (GO:0006216) | 6.23285319 |
| 5 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 5.43175061 |
| 6 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 5.21427901 |
| 7 | positive regulation of interleukin-8 secretion (GO:2000484) | 4.29115548 |
| 8 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.14765777 |
| 9 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.10779038 |
| 10 | regulation of regulatory T cell differentiation (GO:0045589) | 4.08535905 |
| 11 | sequestering of actin monomers (GO:0042989) | 3.90178447 |
| 12 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.87897789 |
| 13 | proteasome assembly (GO:0043248) | 3.85689111 |
| 14 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.83523993 |
| 15 | regulation of interleukin-8 secretion (GO:2000482) | 3.78244496 |
| 16 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.78099427 |
| 17 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.78099427 |
| 18 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.78099427 |
| 19 | regulation of chronic inflammatory response (GO:0002676) | 3.77597302 |
| 20 | negative regulation of T cell apoptotic process (GO:0070233) | 3.76778417 |
| 21 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.75206512 |
| 22 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.75206512 |
| 23 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.73201519 |
| 24 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.73201519 |
| 25 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.68414350 |
| 26 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.66683375 |
| 27 | negative regulation of ligase activity (GO:0051352) | 3.66683375 |
| 28 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.57916973 |
| 29 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.57916973 |
| 30 | iron-sulfur cluster assembly (GO:0016226) | 3.56868049 |
| 31 | metallo-sulfur cluster assembly (GO:0031163) | 3.56868049 |
| 32 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.56633759 |
| 33 | positive thymic T cell selection (GO:0045059) | 3.54396797 |
| 34 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.52775293 |
| 35 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.51029866 |
| 36 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.49257512 |
| 37 | negative regulation by host of viral transcription (GO:0043922) | 3.48951595 |
| 38 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.45429900 |
| 39 | positive regulation of prostaglandin secretion (GO:0032308) | 3.40638514 |
| 40 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.37328346 |
| 41 | positive regulation of calcium-mediated signaling (GO:0050850) | 3.36709902 |
| 42 | mast cell activation involved in immune response (GO:0002279) | 3.36375410 |
| 43 | mast cell degranulation (GO:0043303) | 3.36375410 |
| 44 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.31924583 |
| 45 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.31311230 |
| 46 | ATP synthesis coupled proton transport (GO:0015986) | 3.29823111 |
| 47 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.29823111 |
| 48 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.26592427 |
| 49 | positive T cell selection (GO:0043368) | 3.26288228 |
| 50 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.26009057 |
| 51 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.25377767 |
| 52 | eosinophil chemotaxis (GO:0048245) | 3.24933078 |
| 53 | rRNA modification (GO:0000154) | 3.21919210 |
| 54 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.21278213 |
| 55 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.20485009 |
| 56 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.19660497 |
| 57 | actin nucleation (GO:0045010) | 3.15334473 |
| 58 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.10810328 |
| 59 | positive regulation of cell cycle arrest (GO:0071158) | 3.10767129 |
| 60 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 3.07049206 |
| 61 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.05017668 |
| 62 | positive regulation of ligase activity (GO:0051351) | 3.04277395 |
| 63 | T cell migration (GO:0072678) | 3.02434507 |
| 64 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 3.00154696 |
| 65 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 2.99836376 |
| 66 | mannosylation (GO:0097502) | 2.99235815 |
| 67 | negative regulation of lymphocyte apoptotic process (GO:0070229) | 2.97636273 |
| 68 | L-methionine salvage (GO:0071267) | 2.97628908 |
| 69 | L-methionine biosynthetic process (GO:0071265) | 2.97628908 |
| 70 | amino acid salvage (GO:0043102) | 2.97628908 |
| 71 | respiratory electron transport chain (GO:0022904) | 2.96113870 |
| 72 | electron transport chain (GO:0022900) | 2.94643616 |
| 73 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.93832367 |
| 74 | eosinophil migration (GO:0072677) | 2.92963363 |
| 75 | regulation of cellular amine metabolic process (GO:0033238) | 2.91530580 |
| 76 | negative regulation of viral genome replication (GO:0045071) | 2.88234334 |
| 77 | termination of RNA polymerase III transcription (GO:0006386) | 2.86146221 |
| 78 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.86146221 |
| 79 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.83524383 |
| 80 | response to interferon-beta (GO:0035456) | 2.82763566 |
| 81 | adenosine metabolic process (GO:0046085) | 2.80941988 |
| 82 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.80805742 |
| 83 | DNA dealkylation (GO:0035510) | 2.80693235 |
| 84 | respiratory chain complex IV assembly (GO:0008535) | 2.77990064 |
| 85 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.77772451 |
| 86 | NADH dehydrogenase complex assembly (GO:0010257) | 2.77772451 |
| 87 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.77772451 |
| 88 | regulation of T cell apoptotic process (GO:0070232) | 2.76529264 |
| 89 | mast cell activation (GO:0045576) | 2.74963931 |
| 90 | positive regulation of tolerance induction (GO:0002645) | 2.74575499 |
| 91 | cytolysis (GO:0019835) | 2.74297883 |
| 92 | regulation of calcium-mediated signaling (GO:0050848) | 2.73076018 |
| 93 | nucleotide transmembrane transport (GO:1901679) | 2.71646502 |
| 94 | positive regulation of uterine smooth muscle contraction (GO:0070474) | 2.71570442 |
| 95 | regulation of activation of Janus kinase activity (GO:0010533) | 2.71177562 |
| 96 | protein complex biogenesis (GO:0070271) | 2.71095549 |
| 97 | cellular response to interleukin-15 (GO:0071350) | 2.69990347 |
| 98 | pyrimidine nucleoside catabolic process (GO:0046135) | 2.69612960 |
| 99 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 2.66962934 |
| 100 | positive regulation of cell killing (GO:0031343) | 2.66058943 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 5.57940290 |
| 2 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 4.30121090 |
| 3 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.99464130 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.76631925 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.73781967 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.37967627 |
| 7 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.12801126 |
| 8 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.12057946 |
| 9 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.10570042 |
| 10 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.90930380 |
| 11 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.78532933 |
| 12 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.67368783 |
| 13 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.61315685 |
| 14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.45687947 |
| 15 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.31475163 |
| 16 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.23350519 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.11083829 |
| 18 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.05732767 |
| 19 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.01447727 |
| 20 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.00390805 |
| 21 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.95353781 |
| 22 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.90353580 |
| 23 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.86385083 |
| 24 | VDR_22108803_ChIP-Seq_LS180_Human | 1.83726933 |
| 25 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.80784469 |
| 26 | GATA3_26560356_Chip-Seq_TH2_Human | 1.76300844 |
| 27 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.76001803 |
| 28 | MYB_26560356_Chip-Seq_TH2_Human | 1.75112040 |
| 29 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.69546311 |
| 30 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.69468098 |
| 31 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.69147082 |
| 32 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.67071269 |
| 33 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.65701489 |
| 34 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.61574140 |
| 35 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.61088596 |
| 36 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.59801561 |
| 37 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.58912712 |
| 38 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.58185869 |
| 39 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.47258780 |
| 40 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.46624313 |
| 41 | AR_20517297_ChIP-Seq_VCAP_Human | 1.42463236 |
| 42 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.42341685 |
| 43 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.42281741 |
| 44 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.40132605 |
| 45 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.40080155 |
| 46 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.39534255 |
| 47 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.38597351 |
| 48 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.36166898 |
| 49 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.35987253 |
| 50 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.32976074 |
| 51 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.30028728 |
| 52 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.26934043 |
| 53 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.22687429 |
| 54 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.22687429 |
| 55 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.20994154 |
| 56 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.20359781 |
| 57 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.19672208 |
| 58 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.17811144 |
| 59 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.17717771 |
| 60 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.16299637 |
| 61 | GATA1_22025678_ChIP-Seq_K562_Human | 1.14764435 |
| 62 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.13624154 |
| 63 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.13598566 |
| 64 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.13499685 |
| 65 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.13323321 |
| 66 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.12624402 |
| 67 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.11909340 |
| 68 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.11635022 |
| 69 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.08861897 |
| 70 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.07580702 |
| 71 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.07030367 |
| 72 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.05294031 |
| 73 | MYB_26560356_Chip-Seq_TH1_Human | 1.03549595 |
| 74 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.03083931 |
| 75 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.02247851 |
| 76 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.01553316 |
| 77 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.99252067 |
| 78 | GATA3_26560356_Chip-Seq_TH1_Human | 0.98297624 |
| 79 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.98266972 |
| 80 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.97497968 |
| 81 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.97466723 |
| 82 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.97016340 |
| 83 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.95579081 |
| 84 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.95110594 |
| 85 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.93766696 |
| 86 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.93553967 |
| 87 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.93553967 |
| 88 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.92212529 |
| 89 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.92192797 |
| 90 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.91213858 |
| 91 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.90852027 |
| 92 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.87700186 |
| 93 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.87315336 |
| 94 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 0.86459595 |
| 95 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 0.85863171 |
| 96 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.85669616 |
| 97 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 0.85108801 |
| 98 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.83405067 |
| 99 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.83243940 |
| 100 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.82606263 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005671_abnormal_response_to | 5.49500948 |
| 2 | MP0002138_abnormal_hepatobiliary_system | 3.83054567 |
| 3 | MP0002102_abnormal_ear_morphology | 3.68026714 |
| 4 | MP0009785_altered_susceptibility_to | 2.82497445 |
| 5 | MP0005377_hearing/vestibular/ear_phenot | 2.71384977 |
| 6 | MP0003878_abnormal_ear_physiology | 2.71384977 |
| 7 | MP0001835_abnormal_antigen_presentation | 2.53855670 |
| 8 | MP0002148_abnormal_hypersensitivity_rea | 2.37526432 |
| 9 | MP0000372_irregular_coat_pigmentation | 2.35378520 |
| 10 | MP0005000_abnormal_immune_tolerance | 2.19838249 |
| 11 | MP0009333_abnormal_splenocyte_physiolog | 2.18299845 |
| 12 | MP0006082_CNS_inflammation | 2.16092270 |
| 13 | MP0004147_increased_porphyrin_level | 2.14375586 |
| 14 | MP0001800_abnormal_humoral_immune | 2.14107703 |
| 15 | MP0003763_abnormal_thymus_physiology | 2.11198861 |
| 16 | MP0003011_delayed_dark_adaptation | 1.97684536 |
| 17 | MP0002723_abnormal_immune_serum | 1.96248518 |
| 18 | MP0003786_premature_aging | 1.91891659 |
| 19 | MP0005387_immune_system_phenotype | 1.88035871 |
| 20 | MP0001790_abnormal_immune_system | 1.88035871 |
| 21 | MP0003866_abnormal_defecation | 1.85394197 |
| 22 | MP0002420_abnormal_adaptive_immunity | 1.84629479 |
| 23 | MP0001485_abnormal_pinna_reflex | 1.81895525 |
| 24 | MP0001819_abnormal_immune_cell | 1.81165305 |
| 25 | MP0004145_abnormal_muscle_electrophysio | 1.79510330 |
| 26 | MP0005075_abnormal_melanosome_morpholog | 1.68856409 |
| 27 | MP0000685_abnormal_immune_system | 1.65219613 |
| 28 | MP0001905_abnormal_dopamine_level | 1.64293119 |
| 29 | MP0003436_decreased_susceptibility_to | 1.61324432 |
| 30 | MP0005464_abnormal_platelet_physiology | 1.61317017 |
| 31 | MP0002452_abnormal_antigen_presenting | 1.60645464 |
| 32 | MP0002006_tumorigenesis | 1.60168105 |
| 33 | MP0003806_abnormal_nucleotide_metabolis | 1.58058737 |
| 34 | MP0006072_abnormal_retinal_apoptosis | 1.56002945 |
| 35 | MP0005025_abnormal_response_to | 1.54246468 |
| 36 | MP0002166_altered_tumor_susceptibility | 1.50246073 |
| 37 | MP0003045_fibrosis | 1.47445513 |
| 38 | MP0002405_respiratory_system_inflammati | 1.43821657 |
| 39 | MP0002933_joint_inflammation | 1.43632661 |
| 40 | MP0006036_abnormal_mitochondrial_physio | 1.41528625 |
| 41 | MP0002398_abnormal_bone_marrow | 1.41522966 |
| 42 | MP0000716_abnormal_immune_system | 1.39960256 |
| 43 | MP0003724_increased_susceptibility_to | 1.39503780 |
| 44 | MP0006035_abnormal_mitochondrial_morpho | 1.38840529 |
| 45 | MP0008058_abnormal_DNA_repair | 1.36379220 |
| 46 | MP0000689_abnormal_spleen_morphology | 1.28075220 |
| 47 | MP0001968_abnormal_touch/_nociception | 1.21508938 |
| 48 | MP0008872_abnormal_physiological_respon | 1.21186494 |
| 49 | MP0010155_abnormal_intestine_physiology | 1.18548107 |
| 50 | MP0005551_abnormal_eye_electrophysiolog | 1.17231153 |
| 51 | MP0001845_abnormal_inflammatory_respons | 1.16991504 |
| 52 | MP0001853_heart_inflammation | 1.13444917 |
| 53 | MP0001501_abnormal_sleep_pattern | 1.12086387 |
| 54 | MP0002429_abnormal_blood_cell | 1.11659087 |
| 55 | MP0002722_abnormal_immune_system | 1.10831344 |
| 56 | MP0002837_dystrophic_cardiac_calcinosis | 1.08703362 |
| 57 | MP0002876_abnormal_thyroid_physiology | 1.05459641 |
| 58 | MP0009764_decreased_sensitivity_to | 1.05073000 |
| 59 | MP0005645_abnormal_hypothalamus_physiol | 1.03875801 |
| 60 | MP0001919_abnormal_reproductive_system | 1.02663154 |
| 61 | MP0000703_abnormal_thymus_morphology | 1.02320515 |
| 62 | MP0002733_abnormal_thermal_nociception | 1.01871535 |
| 63 | MP0008877_abnormal_DNA_methylation | 1.01729962 |
| 64 | MP0005379_endocrine/exocrine_gland_phen | 1.00454719 |
| 65 | MP0005084_abnormal_gallbladder_morpholo | 0.98538777 |
| 66 | MP0000569_abnormal_digit_pigmentation | 0.96611245 |
| 67 | MP0005085_abnormal_gallbladder_physiolo | 0.95487217 |
| 68 | MP0003567_abnormal_fetal_cardiomyocyte | 0.94215150 |
| 69 | MP0002419_abnormal_innate_immunity | 0.94068957 |
| 70 | MP0004957_abnormal_blastocyst_morpholog | 0.93777907 |
| 71 | MP0003646_muscle_fatigue | 0.93421600 |
| 72 | MP0001661_extended_life_span | 0.92528096 |
| 73 | MP0008875_abnormal_xenobiotic_pharmacok | 0.92508411 |
| 74 | MP0008469_abnormal_protein_level | 0.91582999 |
| 75 | MP0006276_abnormal_autonomic_nervous | 0.91395373 |
| 76 | MP0005253_abnormal_eye_physiology | 0.90894287 |
| 77 | MP0003448_altered_tumor_morphology | 0.89037847 |
| 78 | MP0001881_abnormal_mammary_gland | 0.88728090 |
| 79 | MP0003137_abnormal_impulse_conducting | 0.87348648 |
| 80 | MP0003172_abnormal_lysosome_physiology | 0.87167464 |
| 81 | MP0009763_increased_sensitivity_to | 0.85385406 |
| 82 | MP0000230_abnormal_systemic_arterial | 0.83443050 |
| 83 | MP0003252_abnormal_bile_duct | 0.81978353 |
| 84 | MP0003693_abnormal_embryo_hatching | 0.81880219 |
| 85 | MP0005167_abnormal_blood-brain_barrier | 0.81390468 |
| 86 | MP0002163_abnormal_gland_morphology | 0.78031185 |
| 87 | MP0002019_abnormal_tumor_incidence | 0.77729071 |
| 88 | MP0009643_abnormal_urine_homeostasis | 0.77633155 |
| 89 | MP0000613_abnormal_salivary_gland | 0.76672742 |
| 90 | MP0008873_increased_physiological_sensi | 0.76301729 |
| 91 | MP0005636_abnormal_mineral_homeostasis | 0.75184422 |
| 92 | MP0005389_reproductive_system_phenotype | 0.74534415 |
| 93 | MP0003195_calcinosis | 0.73870583 |
| 94 | MP0001764_abnormal_homeostasis | 0.72634398 |
| 95 | MP0001873_stomach_inflammation | 0.71697730 |
| 96 | MP0002736_abnormal_nociception_after | 0.71589308 |
| 97 | MP0004142_abnormal_muscle_tone | 0.69742523 |
| 98 | MP0001970_abnormal_pain_threshold | 0.69343027 |
| 99 | MP0003638_abnormal_response/metabolism_ | 0.69251205 |
| 100 | MP0005646_abnormal_pituitary_gland | 0.69097953 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 4.07631247 |
| 2 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 4.00784703 |
| 3 | Abnormality of alanine metabolism (HP:0010916) | 4.00784703 |
| 4 | Hyperalaninemia (HP:0003348) | 4.00784703 |
| 5 | Aplastic anemia (HP:0001915) | 3.95915460 |
| 6 | IgG deficiency (HP:0004315) | 3.93602610 |
| 7 | Severe combined immunodeficiency (HP:0004430) | 3.92583228 |
| 8 | Hypoproteinemia (HP:0003075) | 3.92135532 |
| 9 | Acute necrotizing encephalopathy (HP:0006965) | 3.86492520 |
| 10 | Abnormality of T cell number (HP:0011839) | 3.84950403 |
| 11 | Mitochondrial inheritance (HP:0001427) | 3.77372381 |
| 12 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.76885550 |
| 13 | Molar tooth sign on MRI (HP:0002419) | 3.62336758 |
| 14 | Abnormality of midbrain morphology (HP:0002418) | 3.62336758 |
| 15 | Hepatocellular necrosis (HP:0001404) | 3.55323291 |
| 16 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 3.53141466 |
| 17 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.48349718 |
| 18 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.48349718 |
| 19 | Stomatitis (HP:0010280) | 3.47844125 |
| 20 | Increased CSF lactate (HP:0002490) | 3.37369039 |
| 21 | Hepatic necrosis (HP:0002605) | 3.35111754 |
| 22 | Acute encephalopathy (HP:0006846) | 3.29871462 |
| 23 | 3-Methylglutaconic aciduria (HP:0003535) | 3.13200694 |
| 24 | Cerebral edema (HP:0002181) | 3.12714833 |
| 25 | Progressive macrocephaly (HP:0004481) | 3.09596623 |
| 26 | Abnormality of T cells (HP:0002843) | 3.02929826 |
| 27 | Combined immunodeficiency (HP:0005387) | 2.99866106 |
| 28 | Increased intramyocellular lipid droplets (HP:0012240) | 2.99394739 |
| 29 | Agammaglobulinemia (HP:0004432) | 2.82858237 |
| 30 | Decreased central vision (HP:0007663) | 2.82482878 |
| 31 | Thyroiditis (HP:0100646) | 2.79427049 |
| 32 | Generalized aminoaciduria (HP:0002909) | 2.72463331 |
| 33 | Type I transferrin isoform profile (HP:0003642) | 2.71448234 |
| 34 | Abnormality of eosinophils (HP:0001879) | 2.68323559 |
| 35 | Increased serum lactate (HP:0002151) | 2.66867651 |
| 36 | Pancreatic cysts (HP:0001737) | 2.65632527 |
| 37 | Abnormality of the prostate (HP:0008775) | 2.65442336 |
| 38 | Abolished electroretinogram (ERG) (HP:0000550) | 2.61357255 |
| 39 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.55143312 |
| 40 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.54995930 |
| 41 | Lactic acidosis (HP:0003128) | 2.54131983 |
| 42 | Increased muscle lipid content (HP:0009058) | 2.51092096 |
| 43 | Retinal dysplasia (HP:0007973) | 2.47848250 |
| 44 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.43495911 |
| 45 | Renal cortical cysts (HP:0000803) | 2.42038807 |
| 46 | Hypoalbuminemia (HP:0003073) | 2.36984136 |
| 47 | Abnormal albumin level (HP:0012116) | 2.36984136 |
| 48 | Bifid tongue (HP:0010297) | 2.36348050 |
| 49 | Increased hepatocellular lipid droplets (HP:0006565) | 2.35900392 |
| 50 | Eosinophilia (HP:0001880) | 2.35465789 |
| 51 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.34755664 |
| 52 | Abnormal protein glycosylation (HP:0012346) | 2.34755664 |
| 53 | Abnormal glycosylation (HP:0012345) | 2.34755664 |
| 54 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.34755664 |
| 55 | Abnormality of T cell physiology (HP:0011840) | 2.32519211 |
| 56 | Tongue fasciculations (HP:0001308) | 2.32206416 |
| 57 | Panhypogammaglobulinemia (HP:0003139) | 2.30949926 |
| 58 | Lipid accumulation in hepatocytes (HP:0006561) | 2.25202677 |
| 59 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.21215390 |
| 60 | Nephronophthisis (HP:0000090) | 2.17895762 |
| 61 | Abnormality of serum amino acid levels (HP:0003112) | 2.17432117 |
| 62 | Optic disc pallor (HP:0000543) | 2.10480397 |
| 63 | CNS demyelination (HP:0007305) | 2.09374542 |
| 64 | Renal Fanconi syndrome (HP:0001994) | 2.08671340 |
| 65 | Increased IgM level (HP:0003496) | 2.07944761 |
| 66 | Meningitis (HP:0001287) | 2.07846623 |
| 67 | Granulocytopenia (HP:0001913) | 2.07751032 |
| 68 | Respiratory failure (HP:0002878) | 2.07273895 |
| 69 | Hypothermia (HP:0002045) | 2.06981178 |
| 70 | Pancreatic fibrosis (HP:0100732) | 2.05561098 |
| 71 | Abnormality of the renal cortex (HP:0011035) | 2.04632016 |
| 72 | IgM deficiency (HP:0002850) | 2.03757129 |
| 73 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.03536696 |
| 74 | Attenuation of retinal blood vessels (HP:0007843) | 2.03422403 |
| 75 | Recurrent corneal erosions (HP:0000495) | 2.02568074 |
| 76 | Pustule (HP:0200039) | 2.02429499 |
| 77 | Cerebral hypomyelination (HP:0006808) | 2.01020656 |
| 78 | True hermaphroditism (HP:0010459) | 1.99714090 |
| 79 | Spastic paraparesis (HP:0002313) | 1.98329163 |
| 80 | Encephalitis (HP:0002383) | 1.95895042 |
| 81 | Constricted visual fields (HP:0001133) | 1.95589957 |
| 82 | Reduced antithrombin III activity (HP:0001976) | 1.93171735 |
| 83 | Degeneration of anterior horn cells (HP:0002398) | 1.92180564 |
| 84 | Abnormality of the anterior horn cell (HP:0006802) | 1.92180564 |
| 85 | Type 2 muscle fiber atrophy (HP:0003554) | 1.92172159 |
| 86 | Exercise intolerance (HP:0003546) | 1.91550639 |
| 87 | Lethargy (HP:0001254) | 1.91290404 |
| 88 | Muscle fibrillation (HP:0010546) | 1.90420106 |
| 89 | Congenital stationary night blindness (HP:0007642) | 1.89288300 |
| 90 | Pancytopenia (HP:0001876) | 1.88485440 |
| 91 | Pulmonary fibrosis (HP:0002206) | 1.87091025 |
| 92 | Nausea (HP:0002018) | 1.85914699 |
| 93 | Autoamputation (HP:0001218) | 1.85657583 |
| 94 | Autoimmune hemolytic anemia (HP:0001890) | 1.84227792 |
| 95 | Microretrognathia (HP:0000308) | 1.83443603 |
| 96 | Recurrent bronchitis (HP:0002837) | 1.83402962 |
| 97 | Abnormality of B cell number (HP:0010975) | 1.82593482 |
| 98 | Leukocytosis (HP:0001974) | 1.81928366 |
| 99 | Emotional lability (HP:0000712) | 1.81027012 |
| 100 | Prostate neoplasm (HP:0100787) | 1.76184369 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 4.21875788 |
| 2 | KDR | 4.09516060 |
| 3 | BCKDK | 3.24692380 |
| 4 | BMPR1B | 3.18324078 |
| 5 | MAP3K12 | 2.94540998 |
| 6 | TESK2 | 2.73958035 |
| 7 | VRK2 | 2.64736349 |
| 8 | BUB1 | 2.53672045 |
| 9 | MAP4K1 | 2.28003357 |
| 10 | ADRBK2 | 2.24416560 |
| 11 | MAPKAPK3 | 2.21353113 |
| 12 | ZAK | 2.10733495 |
| 13 | TRIM28 | 2.05482305 |
| 14 | ITK | 2.02816066 |
| 15 | TIE1 | 2.01296632 |
| 16 | SRPK1 | 1.95787332 |
| 17 | TAOK3 | 1.95435378 |
| 18 | TLK1 | 1.91509176 |
| 19 | TEC | 1.75938695 |
| 20 | STK16 | 1.73924021 |
| 21 | SCYL2 | 1.67906545 |
| 22 | PDK2 | 1.54364310 |
| 23 | VRK1 | 1.54165688 |
| 24 | MST4 | 1.45651751 |
| 25 | NUAK1 | 1.45598129 |
| 26 | MYLK | 1.44336091 |
| 27 | DAPK1 | 1.43164555 |
| 28 | SYK | 1.34497393 |
| 29 | GRK1 | 1.28857346 |
| 30 | FES | 1.28170657 |
| 31 | LIMK1 | 1.27872284 |
| 32 | ERBB3 | 1.26858086 |
| 33 | CSNK1G3 | 1.24811252 |
| 34 | MAP4K2 | 1.13365137 |
| 35 | ZAP70 | 1.13287645 |
| 36 | CDK8 | 1.09212781 |
| 37 | GRK6 | 1.08485980 |
| 38 | RPS6KA4 | 1.07088130 |
| 39 | BCR | 1.07051273 |
| 40 | EIF2AK3 | 1.03172010 |
| 41 | CSNK1G2 | 0.92772026 |
| 42 | KIT | 0.92348658 |
| 43 | TGFBR1 | 0.92113766 |
| 44 | TSSK6 | 0.90312297 |
| 45 | TESK1 | 0.89149721 |
| 46 | LCK | 0.88676788 |
| 47 | PIK3CG | 0.88143190 |
| 48 | CSNK1A1L | 0.85507107 |
| 49 | FRK | 0.85447045 |
| 50 | CSNK1G1 | 0.85046724 |
| 51 | PINK1 | 0.83780658 |
| 52 | BTK | 0.83764100 |
| 53 | CSF1R | 0.81588791 |
| 54 | MAP3K11 | 0.78325663 |
| 55 | PRKCQ | 0.77928689 |
| 56 | TRPM7 | 0.77249310 |
| 57 | INSRR | 0.74135131 |
| 58 | GRK7 | 0.72636932 |
| 59 | PLK3 | 0.72168561 |
| 60 | LYN | 0.69871058 |
| 61 | MATK | 0.68478456 |
| 62 | RPS6KA5 | 0.64839685 |
| 63 | MAP2K6 | 0.63674567 |
| 64 | JAK3 | 0.62707353 |
| 65 | PLK2 | 0.60446963 |
| 66 | IGF1R | 0.58440720 |
| 67 | NME1 | 0.57333439 |
| 68 | CSK | 0.53872853 |
| 69 | CSNK1A1 | 0.53790416 |
| 70 | HCK | 0.48557186 |
| 71 | IKBKB | 0.47823640 |
| 72 | SIK3 | 0.47333337 |
| 73 | IKBKE | 0.45495001 |
| 74 | PRKCE | 0.44176148 |
| 75 | PIK3CA | 0.41386320 |
| 76 | PIM1 | 0.39494334 |
| 77 | MINK1 | 0.39146204 |
| 78 | PHKG2 | 0.38289236 |
| 79 | PHKG1 | 0.38289236 |
| 80 | MAP3K5 | 0.38142652 |
| 81 | MAPK13 | 0.37792048 |
| 82 | WNK3 | 0.37735957 |
| 83 | ABL1 | 0.37411694 |
| 84 | ATR | 0.36765343 |
| 85 | ADRBK1 | 0.36066440 |
| 86 | PRKCA | 0.36024091 |
| 87 | CAMK2A | 0.34738834 |
| 88 | CSNK2A1 | 0.34667399 |
| 89 | OBSCN | 0.34303255 |
| 90 | OXSR1 | 0.34180031 |
| 91 | ALK | 0.32829159 |
| 92 | DAPK3 | 0.32640675 |
| 93 | PTK2B | 0.32524812 |
| 94 | RIPK4 | 0.32514759 |
| 95 | NTRK1 | 0.30910203 |
| 96 | FLT3 | 0.29894925 |
| 97 | EIF2AK1 | 0.29236490 |
| 98 | BLK | 0.28032594 |
| 99 | PRKACA | 0.26949974 |
| 100 | ROCK1 | 0.26902640 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.38346023 |
| 2 | Primary immunodeficiency_Homo sapiens_hsa05340 | 4.47723036 |
| 3 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.23127890 |
| 4 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.90435342 |
| 5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.87129670 |
| 6 | Allograft rejection_Homo sapiens_hsa05330 | 2.82984198 |
| 7 | Parkinsons disease_Homo sapiens_hsa05012 | 2.47925852 |
| 8 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.47152708 |
| 9 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.39889628 |
| 10 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.09823110 |
| 11 | RNA polymerase_Homo sapiens_hsa03020 | 2.07818536 |
| 12 | Protein export_Homo sapiens_hsa03060 | 2.00319213 |
| 13 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.97876396 |
| 14 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.95223237 |
| 15 | Asthma_Homo sapiens_hsa05310 | 1.93475504 |
| 16 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.74711862 |
| 17 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.58131833 |
| 18 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.43695744 |
| 19 | Mismatch repair_Homo sapiens_hsa03430 | 1.43359262 |
| 20 | Alzheimers disease_Homo sapiens_hsa05010 | 1.42048349 |
| 21 | Base excision repair_Homo sapiens_hsa03410 | 1.41801238 |
| 22 | Huntingtons disease_Homo sapiens_hsa05016 | 1.40920279 |
| 23 | Peroxisome_Homo sapiens_hsa04146 | 1.30964681 |
| 24 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.26270181 |
| 25 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.25601949 |
| 26 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.24872610 |
| 27 | DNA replication_Homo sapiens_hsa03030 | 1.24112516 |
| 28 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.18210923 |
| 29 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.12877106 |
| 30 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.10237643 |
| 31 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.09513303 |
| 32 | Homologous recombination_Homo sapiens_hsa03440 | 1.08563005 |
| 33 | RNA degradation_Homo sapiens_hsa03018 | 1.07686844 |
| 34 | Phototransduction_Homo sapiens_hsa04744 | 1.03104129 |
| 35 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.02786636 |
| 36 | Purine metabolism_Homo sapiens_hsa00230 | 1.02558407 |
| 37 | Viral myocarditis_Homo sapiens_hsa05416 | 1.00274353 |
| 38 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.99200009 |
| 39 | Basal transcription factors_Homo sapiens_hsa03022 | 0.98523677 |
| 40 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.96296574 |
| 41 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.95845603 |
| 42 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.95653714 |
| 43 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.94711447 |
| 44 | Ribosome_Homo sapiens_hsa03010 | 0.94491088 |
| 45 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.93952069 |
| 46 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.91422185 |
| 47 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.90374385 |
| 48 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.89541044 |
| 49 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.88445169 |
| 50 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.87669022 |
| 51 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.87028647 |
| 52 | Spliceosome_Homo sapiens_hsa03040 | 0.86816945 |
| 53 | Retinol metabolism_Homo sapiens_hsa00830 | 0.85550106 |
| 54 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.83970388 |
| 55 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.83716088 |
| 56 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.80245339 |
| 57 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.76618516 |
| 58 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.73990413 |
| 59 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.72931931 |
| 60 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.72615313 |
| 61 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.70138565 |
| 62 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.66196343 |
| 63 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.64084289 |
| 64 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.63306907 |
| 65 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.62467583 |
| 66 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.60355977 |
| 67 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.60019604 |
| 68 | RNA transport_Homo sapiens_hsa03013 | 0.59731985 |
| 69 | Measles_Homo sapiens_hsa05162 | 0.59690888 |
| 70 | Salmonella infection_Homo sapiens_hsa05132 | 0.55513215 |
| 71 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.55143039 |
| 72 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.54122947 |
| 73 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.53565442 |
| 74 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.52125932 |
| 75 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.49516557 |
| 76 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.49387499 |
| 77 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.48124843 |
| 78 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.47570152 |
| 79 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.47434169 |
| 80 | Metabolic pathways_Homo sapiens_hsa01100 | 0.47401447 |
| 81 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.46223307 |
| 82 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.46008902 |
| 83 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.45811450 |
| 84 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.42714967 |
| 85 | Shigellosis_Homo sapiens_hsa05131 | 0.42157744 |
| 86 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.41237843 |
| 87 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.39028864 |
| 88 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.36952248 |
| 89 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.33270356 |
| 90 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.32202538 |
| 91 | Olfactory transduction_Homo sapiens_hsa04740 | 0.28675150 |
| 92 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.28168703 |
| 93 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.28110577 |
| 94 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.27944174 |
| 95 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.26473979 |
| 96 | Taste transduction_Homo sapiens_hsa04742 | 0.26368151 |
| 97 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.26279344 |
| 98 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.24368328 |
| 99 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.24050736 |
| 100 | Malaria_Homo sapiens_hsa05144 | 0.24018481 |

