PSMC1P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine ribonucleoside catabolic process (GO:0046133)9.20258420
2DNA deamination (GO:0045006)8.74570463
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.37132927
4pyrimidine nucleoside catabolic process (GO:0046135)4.62917142
5positive regulation of defense response to virus by host (GO:0002230)4.58178363
6chaperone-mediated protein transport (GO:0072321)4.53017352
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.42273945
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.38370249
9negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.17564014
10L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.12707785
11T cell migration (GO:0072678)4.08375887
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.00635975
13ATP synthesis coupled proton transport (GO:0015986)4.00635975
14protein deneddylation (GO:0000338)3.97184504
15regulation of cellular amino acid metabolic process (GO:0006521)3.93288896
16negative regulation of calcium ion transport into cytosol (GO:0010523)3.77519277
17DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.76659144
18negative regulation of ligase activity (GO:0051352)3.71912724
19negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.71912724
20positive regulation of calcium-mediated signaling (GO:0050850)3.66886660
21signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.64621349
22signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.64621349
23signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.64621349
24intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.64118254
25signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.64118254
26negative regulation by host of viral transcription (GO:0043922)3.60263741
27DNA demethylation (GO:0080111)3.54521550
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.50787006
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.48493039
30L-methionine salvage (GO:0071267)3.48055275
31L-methionine biosynthetic process (GO:0071265)3.48055275
32amino acid salvage (GO:0043102)3.48055275
33positive regulation of interleukin-8 secretion (GO:2000484)3.45334838
34signal transduction involved in DNA damage checkpoint (GO:0072422)3.44287832
35signal transduction involved in DNA integrity checkpoint (GO:0072401)3.44287832
36maturation of 5.8S rRNA (GO:0000460)3.41080221
37signal transduction involved in cell cycle checkpoint (GO:0072395)3.39148426
38pyrimidine ribonucleoside metabolic process (GO:0046131)3.38696090
39proteasome assembly (GO:0043248)3.38293877
40respiratory electron transport chain (GO:0022904)3.36110070
41electron transport chain (GO:0022900)3.32812138
42pyrimidine-containing compound catabolic process (GO:0072529)3.31979087
43negative regulation of T cell apoptotic process (GO:0070233)3.31547238
44DNA dealkylation (GO:0035510)3.30428730
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.29017113
46cullin deneddylation (GO:0010388)3.28172935
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.26920922
48protein complex biogenesis (GO:0070271)3.21265847
49deoxyribose phosphate biosynthetic process (GO:0046385)3.20929702
502-deoxyribonucleotide biosynthetic process (GO:0009265)3.20929702
51negative regulation of heart rate (GO:0010459)3.20183688
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.19292777
53NADH dehydrogenase complex assembly (GO:0010257)3.19292777
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19292777
55kynurenine metabolic process (GO:0070189)3.18888085
56rRNA catabolic process (GO:0016075)3.17499715
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15604149
58lymphocyte chemotaxis (GO:0048247)3.09736853
59protein-cofactor linkage (GO:0018065)3.08936153
60nucleoside diphosphate catabolic process (GO:0009134)3.07751215
61antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.06316166
62behavioral response to nicotine (GO:0035095)2.97347219
63mitochondrial respiratory chain complex assembly (GO:0033108)2.95290731
64response to pheromone (GO:0019236)2.94412555
65cytolysis (GO:0019835)2.93146581
66positive regulation of cell cycle arrest (GO:0071158)2.92535968
67regulation of calcium-mediated signaling (GO:0050848)2.91530865
68positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.89763015
69DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.88512325
70eosinophil chemotaxis (GO:0048245)2.87000860
71deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.85300536
72positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.82737974
73negative regulation of viral genome replication (GO:0045071)2.82707754
74positive T cell selection (GO:0043368)2.81280284
75cellular response to interferon-beta (GO:0035458)2.80960718
76regulation of regulatory T cell differentiation (GO:0045589)2.79379144
77platelet dense granule organization (GO:0060155)2.78365899
78positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.73898884
79regulation of cellular amine metabolic process (GO:0033238)2.73248339
80positive regulation of ligase activity (GO:0051351)2.70401338
81positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.67216973
82regulation of T cell mediated cytotoxicity (GO:0001914)2.65339832
83positive regulation of T cell mediated cytotoxicity (GO:0001916)2.64735087
84pyrimidine nucleoside metabolic process (GO:0006213)2.64361481
85tryptophan metabolic process (GO:0006568)2.63108845
86response to interferon-beta (GO:0035456)2.60652715
87eosinophil migration (GO:0072677)2.60316867
88indole-containing compound catabolic process (GO:0042436)2.60189661
89indolalkylamine catabolic process (GO:0046218)2.60189661
90tryptophan catabolic process (GO:0006569)2.60189661
91negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.60145650
92regulation of cell cycle arrest (GO:0071156)2.58927271
93positive regulation of T-helper 1 type immune response (GO:0002827)2.58807554
94regulation of interleukin-8 secretion (GO:2000482)2.57726443
95regulation of ubiquitin-protein transferase activity (GO:0051438)2.56365664
96positive regulation of monocyte chemotaxis (GO:0090026)2.55643565
97regulation of leukocyte mediated cytotoxicity (GO:0001910)2.55463175
98cytidine metabolic process (GO:0046087)10.2152637
99cytidine catabolic process (GO:0006216)10.2152637
100cytidine deamination (GO:0009972)10.2152637

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.65067464
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.01300991
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.87241630
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.81104475
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.56327427
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.24660403
7ZNF274_21170338_ChIP-Seq_K562_Hela3.05499369
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.03468169
9VDR_22108803_ChIP-Seq_LS180_Human2.68937520
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63701369
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.36518421
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.35622877
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.32195774
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30110044
15VDR_23849224_ChIP-Seq_CD4+_Human2.29273607
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.28402309
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21208704
18GBX2_23144817_ChIP-Seq_PC3_Human2.17678912
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.09116957
20TP53_22573176_ChIP-Seq_HFKS_Human2.03877992
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.98464524
22IGF1R_20145208_ChIP-Seq_DFB_Human1.96626069
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87616746
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80166569
25EZH2_22144423_ChIP-Seq_EOC_Human1.79668675
26FOXP3_21729870_ChIP-Seq_TREG_Human1.78950776
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76204612
28MYB_26560356_Chip-Seq_TH2_Human1.67013255
29GATA3_26560356_Chip-Seq_TH2_Human1.65956671
30ELK1_19687146_ChIP-ChIP_HELA_Human1.62609655
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61013196
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.59614611
33TAF15_26573619_Chip-Seq_HEK293_Human1.57048845
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48820737
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48624026
36GATA1_22025678_ChIP-Seq_K562_Human1.48337740
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.46826146
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.46749584
39BCAT_22108803_ChIP-Seq_LS180_Human1.45658303
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.44124945
41GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37163869
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37032332
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.36544888
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36544888
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34615787
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34129608
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33724102
48MYC_18940864_ChIP-ChIP_HL60_Human1.33316533
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32186565
50P300_19829295_ChIP-Seq_ESCs_Human1.27054270
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.24982787
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23399851
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22955211
54PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.22488105
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22470037
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20885417
57CBP_20019798_ChIP-Seq_JUKART_Human1.20885417
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.19564481
59TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18949278
60AR_20517297_ChIP-Seq_VCAP_Human1.17751983
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.17531407
62HTT_18923047_ChIP-ChIP_STHdh_Human1.17144242
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17035016
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15034446
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14653458
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.13869027
67ERG_20517297_ChIP-Seq_VCAP_Human1.12732595
68FOXH1_21741376_ChIP-Seq_EPCs_Human1.12491248
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11880321
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10952499
71MYC_19829295_ChIP-Seq_ESCs_Human1.10617152
72MYB_26560356_Chip-Seq_TH1_Human1.09402838
73TAF2_19829295_ChIP-Seq_ESCs_Human1.09290968
74NANOG_19829295_ChIP-Seq_ESCs_Human1.08885740
75SOX2_19829295_ChIP-Seq_ESCs_Human1.08885740
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07496890
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06874438
78NCOR_22424771_ChIP-Seq_293T_Human1.06564161
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04374372
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03169329
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02943735
82ER_23166858_ChIP-Seq_MCF-7_Human1.00261501
83CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99906707
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98248873
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97884522
86EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97682570
87POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97447266
88NANOG_20526341_ChIP-Seq_ESCs_Human0.96509244
89BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95780741
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95450045
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94791793
92GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94384221
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92319446
94GABP_19822575_ChIP-Seq_HepG2_Human0.91978383
95RNF2_27304074_Chip-Seq_NSC_Mouse0.91268718
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90926729
97IRF8_22096565_ChIP-ChIP_GC-B_Human0.90622670
98GATA3_27048872_Chip-Seq_THYMUS_Human0.90355459
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90339611
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89481312

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.11328063
2MP0004145_abnormal_muscle_electrophysio2.91681467
3MP0001986_abnormal_taste_sensitivity2.88403422
4MP0009785_altered_susceptibility_to2.62375265
5MP0008877_abnormal_DNA_methylation2.49565878
6MP0002102_abnormal_ear_morphology2.44892263
7MP0002163_abnormal_gland_morphology2.44178542
8MP0005645_abnormal_hypothalamus_physiol2.42216600
9MP0002006_tumorigenesis2.26568420
10MP0006292_abnormal_olfactory_placode2.22017825
11MP0001835_abnormal_antigen_presentation2.15959865
12MP0001984_abnormal_olfaction2.05195569
13MP0003787_abnormal_imprinting2.04583245
14MP0003045_fibrosis2.00163765
15MP0002166_altered_tumor_susceptibility1.92400753
16MP0006082_CNS_inflammation1.90226357
17MP0000372_irregular_coat_pigmentation1.81870793
18MP0005377_hearing/vestibular/ear_phenot1.79977242
19MP0003878_abnormal_ear_physiology1.79977242
20MP0008875_abnormal_xenobiotic_pharmacok1.72266857
21MP0005075_abnormal_melanosome_morpholog1.68601497
22MP0002148_abnormal_hypersensitivity_rea1.67609949
23MP0001529_abnormal_vocalization1.65252330
24MP0001501_abnormal_sleep_pattern1.63142238
25MP0001485_abnormal_pinna_reflex1.61393496
26MP0009764_decreased_sensitivity_to1.51949370
27MP0003763_abnormal_thymus_physiology1.50633968
28MP0006072_abnormal_retinal_apoptosis1.49614076
29MP0003448_altered_tumor_morphology1.49000320
30MP0001800_abnormal_humoral_immune1.44799282
31MP0005025_abnormal_response_to1.41785801
32MP0005551_abnormal_eye_electrophysiolog1.40546653
33MP0002723_abnormal_immune_serum1.40510894
34MP0003806_abnormal_nucleotide_metabolis1.39908434
35MP0005379_endocrine/exocrine_gland_phen1.39693913
36MP0005253_abnormal_eye_physiology1.39104576
37MP0001905_abnormal_dopamine_level1.37117924
38MP0003195_calcinosis1.34918455
39MP0002420_abnormal_adaptive_immunity1.34765331
40MP0009333_abnormal_splenocyte_physiolog1.32466406
41MP0001819_abnormal_immune_cell1.29777315
42MP0002638_abnormal_pupillary_reflex1.28804073
43MP0008789_abnormal_olfactory_epithelium1.28059577
44MP0002735_abnormal_chemical_nociception1.27012288
45MP0003567_abnormal_fetal_cardiomyocyte1.26888760
46MP0001853_heart_inflammation1.24439687
47MP0005000_abnormal_immune_tolerance1.22683041
48MP0005248_abnormal_Harderian_gland1.21365872
49MP0004885_abnormal_endolymph1.20260470
50MP0004924_abnormal_behavior1.19255033
51MP0005386_behavior/neurological_phenoty1.19255033
52MP0009745_abnormal_behavioral_response1.18814736
53MP0001486_abnormal_startle_reflex1.15970609
54MP0003866_abnormal_defecation1.14879004
55MP0001790_abnormal_immune_system1.14387199
56MP0005387_immune_system_phenotype1.14387199
57MP0003718_maternal_effect1.12428268
58MP0002277_abnormal_respiratory_mucosa1.10808011
59MP0003786_premature_aging1.10700268
60MP0000647_abnormal_sebaceous_gland1.08650690
61MP0002090_abnormal_vision1.07487552
62MP0005165_increased_susceptibility_to1.06651887
63MP0003879_abnormal_hair_cell1.04648842
64MP0002272_abnormal_nervous_system1.03282159
65MP0002452_abnormal_antigen_presenting1.03117760
66MP0001346_abnormal_lacrimal_gland1.00444298
67MP0001970_abnormal_pain_threshold0.97177928
68MP0000631_abnormal_neuroendocrine_gland0.96955532
69MP0001188_hyperpigmentation0.96775299
70MP0008873_increased_physiological_sensi0.96544723
71MP0004484_altered_response_of0.95982528
72MP0006036_abnormal_mitochondrial_physio0.95825211
73MP0001968_abnormal_touch/_nociception0.95460868
74MP0002138_abnormal_hepatobiliary_system0.95085930
75MP0001542_abnormal_bone_strength0.93723704
76MP0009046_muscle_twitch0.93513837
77MP0005423_abnormal_somatic_nervous0.93363485
78MP0000716_abnormal_immune_system0.92219332
79MP0002733_abnormal_thermal_nociception0.91876017
80MP0008872_abnormal_physiological_respon0.90005915
81MP0002736_abnormal_nociception_after0.89377721
82MP0008007_abnormal_cellular_replicative0.89069898
83MP0002837_dystrophic_cardiac_calcinosis0.88042460
84MP0002398_abnormal_bone_marrow0.87410518
85MP0001919_abnormal_reproductive_system0.86690859
86MP0005389_reproductive_system_phenotype0.85609685
87MP0003436_decreased_susceptibility_to0.81848921
88MP0005646_abnormal_pituitary_gland0.79587915
89MP0009763_increased_sensitivity_to0.79233391
90MP0004142_abnormal_muscle_tone0.77784312
91MP0001764_abnormal_homeostasis0.77531654
92MP0002752_abnormal_somatic_nervous0.77271517
93MP0000689_abnormal_spleen_morphology0.77097031
94MP0002419_abnormal_innate_immunity0.76604238
95MP0001440_abnormal_grooming_behavior0.75824059
96MP0002909_abnormal_adrenal_gland0.75670007
97MP0001845_abnormal_inflammatory_respons0.75448981
98MP0005332_abnormal_amino_acid0.75199864
99MP0003011_delayed_dark_adaptation0.74647895
100MP0000858_altered_metastatic_potential0.74188803

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)7.14791888
2T lymphocytopenia (HP:0005403)4.42331518
3Abnormality of T cell number (HP:0011839)4.11625115
4Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.07043270
5Decreased activity of mitochondrial respiratory chain (HP:0008972)4.07043270
6Hepatocellular necrosis (HP:0001404)4.00254179
7Acute necrotizing encephalopathy (HP:0006965)3.84880215
8Severe combined immunodeficiency (HP:0004430)3.75746565
9Hepatic necrosis (HP:0002605)3.70196701
10Mitochondrial inheritance (HP:0001427)3.66770973
11IgG deficiency (HP:0004315)3.61091839
12Renal cortical cysts (HP:0000803)3.59824928
13Abnormal mitochondria in muscle tissue (HP:0008316)3.59216774
143-Methylglutaconic aciduria (HP:0003535)3.51941974
15Elevated erythrocyte sedimentation rate (HP:0003565)3.50107219
16Combined immunodeficiency (HP:0005387)3.29376453
17Adrenal hypoplasia (HP:0000835)3.25635045
18Pancreatic cysts (HP:0001737)3.23167832
19Decreased central vision (HP:0007663)3.18972346
20Increased IgM level (HP:0003496)3.13336901
21Increased CSF lactate (HP:0002490)3.12490642
22Recurrent bronchitis (HP:0002837)3.02812599
23Progressive macrocephaly (HP:0004481)2.96133514
24Acute encephalopathy (HP:0006846)2.93647668
25Abnormality of T cells (HP:0002843)2.89235994
26Thyroiditis (HP:0100646)2.85035515
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.84281855
28Abnormality of eosinophils (HP:0001879)2.83868089
29Abnormality of midbrain morphology (HP:0002418)2.83585186
30Molar tooth sign on MRI (HP:0002419)2.83585186
31Cerebral edema (HP:0002181)2.62930069
32Abolished electroretinogram (ERG) (HP:0000550)2.59368127
33Type 2 muscle fiber atrophy (HP:0003554)2.54566108
34Generalized aminoaciduria (HP:0002909)2.51480351
35Abnormal rod and cone electroretinograms (HP:0008323)2.49651796
36Septo-optic dysplasia (HP:0100842)2.45282078
37Increased intramyocellular lipid droplets (HP:0012240)2.45007666
38Absent septum pellucidum (HP:0001331)2.39361816
39Cerebral hypomyelination (HP:0006808)2.38605723
40Muscle fiber atrophy (HP:0100295)2.36677227
41Optic disc pallor (HP:0000543)2.36516019
42True hermaphroditism (HP:0010459)2.35970895
43Autoimmune hemolytic anemia (HP:0001890)2.35968192
44Congenital, generalized hypertrichosis (HP:0004540)2.34064301
45Methylmalonic aciduria (HP:0012120)2.33808381
46Eosinophilia (HP:0001880)2.32552364
47Type I transferrin isoform profile (HP:0003642)2.30184464
48Congenital stationary night blindness (HP:0007642)2.29434601
49Hypoproteinemia (HP:0003075)2.28081350
50Nephronophthisis (HP:0000090)2.27247967
51Methylmalonic acidemia (HP:0002912)2.26935320
52Pancreatic fibrosis (HP:0100732)2.25327328
53Increased serum lactate (HP:0002151)2.23127820
54Abnormality of the renal cortex (HP:0011035)2.21649922
55Abnormality of B cell number (HP:0010975)2.20712336
56Chronic sinusitis (HP:0011109)2.18737671
57Pancytopenia (HP:0001876)2.13628893
58Dicarboxylic aciduria (HP:0003215)2.12187187
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.12187187
60Bronchitis (HP:0012387)2.11531456
61Aplasia/hypoplasia of the uterus (HP:0008684)2.10015517
62B lymphocytopenia (HP:0010976)2.08658852
63Respiratory failure (HP:0002878)2.06866847
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.06653808
65CNS demyelination (HP:0007305)2.06030209
66Autoimmune thrombocytopenia (HP:0001973)2.01144734
67Sclerocornea (HP:0000647)2.00655812
68Lactic acidosis (HP:0003128)1.98232320
69Abnormality of the alveolar ridges (HP:0006477)1.97683257
70Abnormality of the pons (HP:0007361)1.94569776
71Hypoplasia of the uterus (HP:0000013)1.92656132
72Hypergammaglobulinemia (HP:0010702)1.90886029
73Neuroendocrine neoplasm (HP:0100634)1.88399765
74Encephalitis (HP:0002383)1.87972304
75Abnormality of the septum pellucidum (HP:0007375)1.86701617
76Leukocytosis (HP:0001974)1.86192829
77Submucous cleft hard palate (HP:0000176)1.85991450
78Constricted visual fields (HP:0001133)1.85967565
79Increased muscle lipid content (HP:0009058)1.85451900
80Reduced antithrombin III activity (HP:0001976)1.85280463
81Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85046225
82Emotional lability (HP:0000712)1.84957118
83Type II lissencephaly (HP:0007260)1.84245964
84Parakeratosis (HP:0001036)1.83562913
85Increased neuronal autofluorescent lipopigment (HP:0002074)1.79793508
86Lethargy (HP:0001254)1.77266041
87Abnormality of the prostate (HP:0008775)1.76259048
88Abnormality of the renal medulla (HP:0100957)1.73585321
89Recurrent corneal erosions (HP:0000495)1.73384536
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72318076
91Abnormal albumin level (HP:0012116)1.72307834
92Hypoalbuminemia (HP:0003073)1.72307834
93Recurrent gram-negative bacterial infections (HP:0005420)1.71958718
94Sparse eyelashes (HP:0000653)1.71126813
95Conical tooth (HP:0000698)1.70618885
96Lymphoma (HP:0002665)1.70312895
97Congenital ichthyosiform erythroderma (HP:0007431)1.66981777
98Palpitations (HP:0001962)1.66060009
99Nonprogressive disorder (HP:0003680)1.65715840
100Neonatal respiratory distress (HP:0002643)1.65382667

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.74843307
2TXK3.73907070
3EIF2AK33.36997099
4STK163.31789519
5BUB13.17567285
6KDR2.95653537
7ZAK2.82130339
8TAOK12.76827649
9SCYL22.68501410
10MAP4K22.66198291
11ADRBK22.64245282
12BMPR22.43746565
13EIF2AK12.19724364
14TESK22.19315328
15SRPK12.15660785
16MST42.07653973
17LIMK12.02544221
18TLK11.82369357
19VRK21.81330201
20CDK191.71850988
21TSSK61.71499742
22NUAK11.60164916
23VRK11.57102777
24WNK31.55055171
25ITK1.44380827
26PRKD31.36664276
27NME11.36375829
28TRIM281.34896418
29KIT1.25084498
30MAP2K71.16327071
31AKT31.13550578
32GRK11.13362633
33FRK1.09421685
34BCKDK1.06694305
35PDK20.97484119
36RIPK40.94240441
37PINK10.93874587
38PIM20.93847748
39BMPR1B0.81148499
40EIF2AK20.80823921
41SYK0.79359773
42IKBKB0.78544521
43PLK30.77128648
44TESK10.74971408
45TIE10.72720262
46PHKG20.72656897
47PHKG10.72656897
48PLK10.68031189
49PRKCQ0.63910361
50NEK60.63384623
51LCK0.62636561
52CAMKK20.62401905
53ROCK10.62027017
54CSNK1G30.60023722
55RPS6KA50.59883344
56MAPK130.58353823
57PIK3CG0.57494725
58TYRO30.56467872
59DYRK20.56368136
60CAMK2A0.55872017
61GRK70.55391380
62CSNK1A1L0.52495798
63TAF10.52276776
64RPS6KA40.49447501
65MAP3K40.46424991
66DYRK1B0.46083431
67PIM10.43172316
68PAK10.41970937
69NEK10.41841197
70INSRR0.41604554
71FES0.41567629
72OBSCN0.40367117
73PRKCA0.39847642
74MKNK20.39673570
75CSNK1A10.39088851
76PRKACA0.38547240
77MAP4K10.38217438
78TEC0.37517713
79CDC70.37308988
80ADRBK10.36887512
81AURKB0.36745112
82MAP3K140.36350966
83ILK0.35834926
84MARK10.35414760
85IKBKE0.35261316
86FYN0.34788547
87CSNK1G10.34070704
88MYLK0.33006335
89CHUK0.32755686
90ACVR1B0.31043083
91DAPK10.30932729
92PRKCD0.30680757
93BTK0.30325706
94BRSK20.29737756
95CSNK1G20.29486339
96ATR0.27575555
97IRAK30.27531416
98FGFR10.27202727
99LYN0.27018979
100CDK60.26285941

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.75186161
2Primary immunodeficiency_Homo sapiens_hsa053403.76164026
3Oxidative phosphorylation_Homo sapiens_hsa001903.59068307
4Parkinsons disease_Homo sapiens_hsa050123.23559067
5Protein export_Homo sapiens_hsa030602.40915363
6RNA polymerase_Homo sapiens_hsa030202.28184848
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.14649764
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10909266
9Alzheimers disease_Homo sapiens_hsa050102.06865340
10Huntingtons disease_Homo sapiens_hsa050161.97768230
11Antigen processing and presentation_Homo sapiens_hsa046121.93168515
12Cardiac muscle contraction_Homo sapiens_hsa042601.88920467
13Sulfur metabolism_Homo sapiens_hsa009201.87431815
14Autoimmune thyroid disease_Homo sapiens_hsa053201.84362432
15Allograft rejection_Homo sapiens_hsa053301.78911692
16Graft-versus-host disease_Homo sapiens_hsa053321.77607163
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.72211332
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72009175
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.67863629
20Type I diabetes mellitus_Homo sapiens_hsa049401.66216637
21Ribosome_Homo sapiens_hsa030101.60005704
22Mismatch repair_Homo sapiens_hsa034301.39593212
23Linoleic acid metabolism_Homo sapiens_hsa005911.32458388
24Homologous recombination_Homo sapiens_hsa034401.32054939
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28137134
26Fatty acid elongation_Homo sapiens_hsa000621.24512713
27Basal transcription factors_Homo sapiens_hsa030221.19905113
28Hematopoietic cell lineage_Homo sapiens_hsa046401.19811686
29Steroid biosynthesis_Homo sapiens_hsa001001.15040169
30Propanoate metabolism_Homo sapiens_hsa006401.14771859
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13000256
32Pyrimidine metabolism_Homo sapiens_hsa002401.11942199
33DNA replication_Homo sapiens_hsa030301.10646502
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.10366555
35Rheumatoid arthritis_Homo sapiens_hsa053231.09466311
36Phototransduction_Homo sapiens_hsa047441.09463183
37Tryptophan metabolism_Homo sapiens_hsa003801.08883040
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07231149
39Nicotine addiction_Homo sapiens_hsa050331.05106844
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01192159
41RNA degradation_Homo sapiens_hsa030180.98067009
42Purine metabolism_Homo sapiens_hsa002300.97592234
43Spliceosome_Homo sapiens_hsa030400.89143269
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88244743
45Asthma_Homo sapiens_hsa053100.87624571
46Caffeine metabolism_Homo sapiens_hsa002320.86638105
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81481979
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.80669420
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80231653
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71102402
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70170912
52Shigellosis_Homo sapiens_hsa051310.70012726
53Nucleotide excision repair_Homo sapiens_hsa034200.69458706
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.69331475
55T cell receptor signaling pathway_Homo sapiens_hsa046600.68226608
56RNA transport_Homo sapiens_hsa030130.67919713
57Chemical carcinogenesis_Homo sapiens_hsa052040.67860319
58Regulation of autophagy_Homo sapiens_hsa041400.66836009
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65574542
60Butanoate metabolism_Homo sapiens_hsa006500.65152036
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.64884490
62Peroxisome_Homo sapiens_hsa041460.63978304
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62974486
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61881547
65beta-Alanine metabolism_Homo sapiens_hsa004100.61488067
66Retinol metabolism_Homo sapiens_hsa008300.60649400
67GABAergic synapse_Homo sapiens_hsa047270.59891910
68Arachidonic acid metabolism_Homo sapiens_hsa005900.57226586
69Epstein-Barr virus infection_Homo sapiens_hsa051690.56616780
70Collecting duct acid secretion_Homo sapiens_hsa049660.55526873
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55065511
72Olfactory transduction_Homo sapiens_hsa047400.54530844
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53643118
74Non-homologous end-joining_Homo sapiens_hsa034500.53430282
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53031709
76Viral myocarditis_Homo sapiens_hsa054160.52726616
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52369869
78Nitrogen metabolism_Homo sapiens_hsa009100.51638649
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50739728
80Taste transduction_Homo sapiens_hsa047420.50376400
81Morphine addiction_Homo sapiens_hsa050320.48992656
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48749360
83Fat digestion and absorption_Homo sapiens_hsa049750.46798375
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46118399
85Selenocompound metabolism_Homo sapiens_hsa004500.45417868
86One carbon pool by folate_Homo sapiens_hsa006700.44833989
87Fanconi anemia pathway_Homo sapiens_hsa034600.43604076
88Oocyte meiosis_Homo sapiens_hsa041140.42831492
89Metabolic pathways_Homo sapiens_hsa011000.42300548
90Measles_Homo sapiens_hsa051620.39266593
91Systemic lupus erythematosus_Homo sapiens_hsa053220.38423067
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38147284
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36717988
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.35339792
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33893889
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32383298
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.29599417
98Glutathione metabolism_Homo sapiens_hsa004800.28855760
99Ether lipid metabolism_Homo sapiens_hsa005650.26543661
100Salmonella infection_Homo sapiens_hsa051320.25734006

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