PSMC1P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)8.56059941
2cytidine metabolic process (GO:0046087)8.56059941
3cytidine catabolic process (GO:0006216)8.56059941
4DNA deamination (GO:0045006)8.24459173
5pyrimidine ribonucleoside catabolic process (GO:0046133)7.60440408
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.49446078
7regulation of RIG-I signaling pathway (GO:0039535)4.64299576
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.52273080
9preassembly of GPI anchor in ER membrane (GO:0016254)4.32132804
10regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.31011926
11mannosylation (GO:0097502)4.16534168
12negative regulation by host of viral transcription (GO:0043922)4.14939037
13protein neddylation (GO:0045116)4.00184030
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.96180153
15regulation of regulatory T cell differentiation (GO:0045589)3.93557449
16regulation of cellular amino acid metabolic process (GO:0006521)3.93108949
17pyrimidine nucleoside catabolic process (GO:0046135)3.77908799
18energy coupled proton transport, down electrochemical gradient (GO:0015985)3.77825233
19ATP synthesis coupled proton transport (GO:0015986)3.77825233
20eosinophil chemotaxis (GO:0048245)3.77663205
21negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.76867022
22positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.65917704
23DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.64122355
24proteasome assembly (GO:0043248)3.63163462
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.58487656
26signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.56784110
27signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.56784110
28signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.56784110
29positive regulation of T cell chemotaxis (GO:0010820)3.53390514
30regulation of T cell chemotaxis (GO:0010819)3.53390514
31signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.52638718
32intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.52638718
33positive regulation of natural killer cell mediated immunity (GO:0002717)3.49173783
34signal transduction involved in cell cycle checkpoint (GO:0072395)3.47421734
35DNA demethylation (GO:0080111)3.46651716
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.45443860
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.45443860
38positive regulation of interleukin-8 secretion (GO:2000484)3.44142369
39eosinophil migration (GO:0072677)3.42180547
40electron transport chain (GO:0022900)3.40814938
41respiratory electron transport chain (GO:0022904)3.39923855
42cytolysis (GO:0019835)3.37708181
43negative regulation of ligase activity (GO:0051352)3.37260102
44negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37260102
45negative regulation of T cell apoptotic process (GO:0070233)3.36025528
46signal transduction involved in DNA damage checkpoint (GO:0072422)3.34296437
47signal transduction involved in DNA integrity checkpoint (GO:0072401)3.34296437
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.33544625
49DNA dealkylation (GO:0035510)3.31055366
50positive regulation of monocyte chemotaxis (GO:0090026)3.28777726
51regulation of activation of Janus kinase activity (GO:0010533)3.26135744
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.22268159
53GPI anchor biosynthetic process (GO:0006506)3.19924895
54regulation of chronic inflammatory response (GO:0002676)3.16405493
55regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16340455
56nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.14295910
57iron-sulfur cluster assembly (GO:0016226)3.10914376
58metallo-sulfur cluster assembly (GO:0031163)3.10914376
59Arp2/3 complex-mediated actin nucleation (GO:0034314)3.08430115
60GPI anchor metabolic process (GO:0006505)3.07084017
61exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05773289
62negative regulation of viral genome replication (GO:0045071)3.04350241
63chaperone-mediated protein transport (GO:0072321)3.03804048
64C-terminal protein lipidation (GO:0006501)3.02789458
65positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.01696488
66water-soluble vitamin biosynthetic process (GO:0042364)3.01265518
67protein deneddylation (GO:0000338)2.97745409
68regulation of chemokine-mediated signaling pathway (GO:0070099)2.96610899
69antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.95730582
70C-terminal protein amino acid modification (GO:0018410)2.93891407
71programmed necrotic cell death (GO:0097300)2.92284319
72positive T cell selection (GO:0043368)2.92138004
73sequestering of actin monomers (GO:0042989)2.88513855
74positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.86271038
75transcription elongation from RNA polymerase III promoter (GO:0006385)2.85356724
76termination of RNA polymerase III transcription (GO:0006386)2.85356724
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.82754091
78regulation of cellular amine metabolic process (GO:0033238)2.80005750
79regulation of natural killer cell mediated immunity (GO:0002715)2.79693744
80regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.79693744
81actin nucleation (GO:0045010)2.78387126
82rRNA modification (GO:0000154)2.78166974
83RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.76700910
84regulation of mononuclear cell migration (GO:0071675)2.76523103
85maturation of 5.8S rRNA (GO:0000460)2.76382571
86positive regulation of cell cycle arrest (GO:0071158)2.73591879
87cullin deneddylation (GO:0010388)2.72086485
88regulation of lymphocyte chemotaxis (GO:1901623)2.71296587
89DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.69871318
90positive regulation of ligase activity (GO:0051351)2.69864835
91cornea development in camera-type eye (GO:0061303)2.69772824
92regulation of interleukin-8 secretion (GO:2000482)2.69582044
93meiotic chromosome segregation (GO:0045132)2.64314833
94positive regulation of translational initiation (GO:0045948)2.63380406
95tryptophan metabolic process (GO:0006568)2.61966454
96pyrimidine ribonucleoside metabolic process (GO:0046131)2.59488411
97protein peptidyl-prolyl isomerization (GO:0000413)2.57517535
98intracellular protein transmembrane import (GO:0044743)2.57488151
99modulation by host of viral transcription (GO:0043921)2.57468421
100modulation by host of symbiont transcription (GO:0052472)2.57468421

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.80106129
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.11816451
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.09672819
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.92134893
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.75071420
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.08017652
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.98566641
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80839625
9ZNF274_21170338_ChIP-Seq_K562_Hela2.72707035
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.66605646
11VDR_23849224_ChIP-Seq_CD4+_Human2.55469332
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.53915156
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.52988293
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44530447
15VDR_22108803_ChIP-Seq_LS180_Human2.33577404
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.30838876
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26736465
18ELK1_19687146_ChIP-ChIP_HELA_Human2.13042417
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.10742098
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.08779331
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02815159
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.95792828
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.94117921
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.93738540
25IGF1R_20145208_ChIP-Seq_DFB_Human1.83224167
26FOXP3_21729870_ChIP-Seq_TREG_Human1.80787413
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66064542
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65933218
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.62705518
30HTT_18923047_ChIP-ChIP_STHdh_Human1.55877117
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49361556
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46815465
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46319489
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45578167
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44765554
36FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44627800
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.44627800
38MYC_18940864_ChIP-ChIP_HL60_Human1.44586421
39AR_20517297_ChIP-Seq_VCAP_Human1.42628673
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.38876586
41GATA3_26560356_Chip-Seq_TH2_Human1.38382230
42ELK1_22589737_ChIP-Seq_MCF10A_Human1.37322716
43TP53_22573176_ChIP-Seq_HFKS_Human1.35811415
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33324758
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33239154
46SOX2_19829295_ChIP-Seq_ESCs_Human1.33183678
47NANOG_19829295_ChIP-Seq_ESCs_Human1.33183678
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31135597
49EWS_26573619_Chip-Seq_HEK293_Human1.30385605
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29146580
51CBP_20019798_ChIP-Seq_JUKART_Human1.28753609
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28753609
53GATA3_27048872_Chip-Seq_THYMUS_Human1.28199339
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24708425
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23190180
56GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.21567329
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20775595
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20017478
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17774838
60GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.16029624
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14506493
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13145025
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.12417401
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11460892
65DCP1A_22483619_ChIP-Seq_HELA_Human1.10912689
66NCOR_22424771_ChIP-Seq_293T_Human1.09350306
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09084645
68GABP_19822575_ChIP-Seq_HepG2_Human1.09073538
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.08906350
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08618530
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08578576
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07616812
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07374330
74RBPJ_21746931_ChIP-Seq_IB4_Human1.06444233
75GATA6_21074721_ChIP-Seq_CACO-2_Human1.05962640
76P300_19829295_ChIP-Seq_ESCs_Human1.05854260
77EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05581868
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05446091
79NANOG_20526341_ChIP-Seq_ESCs_Human1.05038036
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04896519
81RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04837881
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04761971
83FOXH1_21741376_ChIP-Seq_EPCs_Human1.04480768
84TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02893093
85FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02663038
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02359676
87FUS_26573619_Chip-Seq_HEK293_Human1.02103470
88MYC_18555785_ChIP-Seq_MESCs_Mouse1.01479663
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00986579
90GATA3_26560356_Chip-Seq_TH1_Human1.00841534
91PHF8_20622853_ChIP-Seq_HELA_Human1.00124905
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99199431
93TAF15_26573619_Chip-Seq_HEK293_Human0.98627272
94MYB_26560356_Chip-Seq_TH2_Human0.98497378
95STAT1_20625510_ChIP-Seq_HELA_Human0.98427976
96CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.97863029
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.95931371
98ERG_20517297_ChIP-Seq_VCAP_Human0.93745299
99BCAT_22108803_ChIP-Seq_LS180_Human0.93592101
100TAF2_19829295_ChIP-Seq_ESCs_Human0.93383452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.68597320
2MP0000372_irregular_coat_pigmentation3.86110893
3MP0003195_calcinosis2.63588008
4MP0003011_delayed_dark_adaptation2.38459824
5MP0002837_dystrophic_cardiac_calcinosis2.28719012
6MP0008877_abnormal_DNA_methylation2.28109537
7MP0009785_altered_susceptibility_to2.22673384
8MP0002138_abnormal_hepatobiliary_system2.22635658
9MP0002102_abnormal_ear_morphology2.21876290
10MP0001188_hyperpigmentation2.11598582
11MP0001905_abnormal_dopamine_level2.09527218
12MP0006082_CNS_inflammation1.96701169
13MP0003786_premature_aging1.94027001
14MP0002148_abnormal_hypersensitivity_rea1.89628835
15MP0009333_abnormal_splenocyte_physiolog1.87242789
16MP0002006_tumorigenesis1.83856543
17MP0002166_altered_tumor_susceptibility1.82811745
18MP0006035_abnormal_mitochondrial_morpho1.77057148
19MP0006276_abnormal_autonomic_nervous1.76680754
20MP0002909_abnormal_adrenal_gland1.76555805
21MP0006072_abnormal_retinal_apoptosis1.73674719
22MP0008872_abnormal_physiological_respon1.72711216
23MP0001835_abnormal_antigen_presentation1.72424491
24MP0005084_abnormal_gallbladder_morpholo1.69719762
25MP0004145_abnormal_muscle_electrophysio1.66881650
26MP0006036_abnormal_mitochondrial_physio1.61954639
27MP0005075_abnormal_melanosome_morpholog1.61417786
28MP0006292_abnormal_olfactory_placode1.46104533
29MP0002163_abnormal_gland_morphology1.45413792
30MP0005253_abnormal_eye_physiology1.45095133
31MP0003866_abnormal_defecation1.44597792
32MP0005000_abnormal_immune_tolerance1.41294660
33MP0005387_immune_system_phenotype1.38998968
34MP0001790_abnormal_immune_system1.38998968
35MP0001800_abnormal_humoral_immune1.38878730
36MP0002234_abnormal_pharynx_morphology1.33215093
37MP0003880_abnormal_central_pattern1.32620369
38MP0003448_altered_tumor_morphology1.31465904
39MP0002876_abnormal_thyroid_physiology1.30440304
40MP0003878_abnormal_ear_physiology1.30255618
41MP0005377_hearing/vestibular/ear_phenot1.30255618
42MP0002723_abnormal_immune_serum1.27223625
43MP0003567_abnormal_fetal_cardiomyocyte1.27087649
44MP0005645_abnormal_hypothalamus_physiol1.26698173
45MP0001485_abnormal_pinna_reflex1.26492199
46MP0002420_abnormal_adaptive_immunity1.26031011
47MP0005551_abnormal_eye_electrophysiolog1.25120043
48MP0003137_abnormal_impulse_conducting1.22672188
49MP0009764_decreased_sensitivity_to1.22319396
50MP0003763_abnormal_thymus_physiology1.20470641
51MP0001819_abnormal_immune_cell1.18906781
52MP0001873_stomach_inflammation1.16348724
53MP0005670_abnormal_white_adipose1.15037537
54MP0000631_abnormal_neuroendocrine_gland1.13096662
55MP0001968_abnormal_touch/_nociception1.11981902
56MP0001529_abnormal_vocalization1.11947380
57MP0008875_abnormal_xenobiotic_pharmacok1.11345436
58MP0004782_abnormal_surfactant_physiolog1.10900931
59MP0009046_muscle_twitch1.10731487
60MP0001501_abnormal_sleep_pattern1.09733594
61MP0001984_abnormal_olfaction1.05888806
62MP0003718_maternal_effect1.03415228
63MP0000689_abnormal_spleen_morphology1.03035710
64MP0005389_reproductive_system_phenotype1.00970680
65MP0008873_increased_physiological_sensi0.97967517
66MP0005379_endocrine/exocrine_gland_phen0.97633866
67MP0000716_abnormal_immune_system0.97537078
68MP0005025_abnormal_response_to0.96912606
69MP0004215_abnormal_myocardial_fiber0.95409367
70MP0002277_abnormal_respiratory_mucosa0.93845255
71MP0005167_abnormal_blood-brain_barrier0.92878698
72MP0008995_early_reproductive_senescence0.91968628
73MP0002822_catalepsy0.91819091
74MP0001919_abnormal_reproductive_system0.91615107
75MP0009763_increased_sensitivity_to0.91043322
76MP0001845_abnormal_inflammatory_respons0.90482359
77MP0002693_abnormal_pancreas_physiology0.90264334
78MP0004142_abnormal_muscle_tone0.89007698
79MP0002452_abnormal_antigen_presenting0.87841184
80MP0001764_abnormal_homeostasis0.85905752
81MP0008007_abnormal_cellular_replicative0.85457214
82MP0002398_abnormal_bone_marrow0.84650058
83MP0002733_abnormal_thermal_nociception0.83295899
84MP0002751_abnormal_autonomic_nervous0.80392950
85MP0009745_abnormal_behavioral_response0.80368565
86MP0001986_abnormal_taste_sensitivity0.78350318
87MP0001970_abnormal_pain_threshold0.78107204
88MP0010155_abnormal_intestine_physiology0.77651543
89MP0005332_abnormal_amino_acid0.76531220
90MP0005410_abnormal_fertilization0.75339177
91MP0002938_white_spotting0.75223162
92MP0008469_abnormal_protein_level0.74980339
93MP0000703_abnormal_thymus_morphology0.74039107
94MP0003646_muscle_fatigue0.73902789
95MP0001881_abnormal_mammary_gland0.73807076
96MP0002429_abnormal_blood_cell0.73583335
97MP0005085_abnormal_gallbladder_physiolo0.72402947
98MP0005636_abnormal_mineral_homeostasis0.71891474
99MP0002933_joint_inflammation0.71792743
100MP0003172_abnormal_lysosome_physiology0.71184811

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.20014848
2Molar tooth sign on MRI (HP:0002419)4.07276509
3Abnormality of midbrain morphology (HP:0002418)4.07276509
4Acute necrotizing encephalopathy (HP:0006965)3.97214693
5Decreased activity of mitochondrial respiratory chain (HP:0008972)3.94419536
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.94419536
7Hepatocellular necrosis (HP:0001404)3.86028467
8Mitochondrial inheritance (HP:0001427)3.79384900
93-Methylglutaconic aciduria (HP:0003535)3.70485845
10Hepatic necrosis (HP:0002605)3.69064697
11Abnormal mitochondria in muscle tissue (HP:0008316)3.66694459
12Acute encephalopathy (HP:0006846)3.66350162
13Increased CSF lactate (HP:0002490)3.57935707
14Pancreatic cysts (HP:0001737)3.41103006
15Decreased central vision (HP:0007663)3.38127396
16T lymphocytopenia (HP:0005403)3.34358241
17Progressive macrocephaly (HP:0004481)3.19529795
18Cerebral edema (HP:0002181)3.17498105
19Abnormality of T cell number (HP:0011839)3.17423862
20Pancreatic fibrosis (HP:0100732)3.16431906
21IgG deficiency (HP:0004315)3.13702463
22Hypoproteinemia (HP:0003075)3.04515271
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.88644515
24Severe combined immunodeficiency (HP:0004430)2.86319307
25True hermaphroditism (HP:0010459)2.63864468
26Abolished electroretinogram (ERG) (HP:0000550)2.63217997
27Increased hepatocellular lipid droplets (HP:0006565)2.57981492
28Increased serum lactate (HP:0002151)2.57350226
29Nephronophthisis (HP:0000090)2.53353293
30Lactic acidosis (HP:0003128)2.52804881
31Increased intramyocellular lipid droplets (HP:0012240)2.45512605
32Abnormal albumin level (HP:0012116)2.44109045
33Hypoalbuminemia (HP:0003073)2.44109045
34Generalized aminoaciduria (HP:0002909)2.41775694
35Amniotic constriction ring (HP:0009775)2.41716784
36Abnormality of placental membranes (HP:0011409)2.41716784
37Decreased electroretinogram (ERG) amplitude (HP:0000654)2.39068542
38Lipid accumulation in hepatocytes (HP:0006561)2.38803370
39Autoimmune hemolytic anemia (HP:0001890)2.38317929
40Type I transferrin isoform profile (HP:0003642)2.34565541
41Elevated erythrocyte sedimentation rate (HP:0003565)2.33030820
42Hypothermia (HP:0002045)2.32902658
43Optic disc pallor (HP:0000543)2.27623318
44Parakeratosis (HP:0001036)2.26562672
45Aplasia/hypoplasia of the uterus (HP:0008684)2.26366496
46Attenuation of retinal blood vessels (HP:0007843)2.23886320
47Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23231210
48Abnormal protein N-linked glycosylation (HP:0012347)2.23231210
49Abnormal protein glycosylation (HP:0012346)2.23231210
50Abnormal glycosylation (HP:0012345)2.23231210
51Spastic paraparesis (HP:0002313)2.21122734
52Abnormality of T cells (HP:0002843)2.20807168
53Respiratory failure (HP:0002878)2.19021446
54Large for gestational age (HP:0001520)2.18727556
55Increased IgM level (HP:0003496)2.13473005
56Abnormality of eosinophils (HP:0001879)2.12667823
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12543191
58Prominent metopic ridge (HP:0005487)2.12329609
59Lethargy (HP:0001254)2.11744995
60Cerebral palsy (HP:0100021)2.11243252
61Thyroiditis (HP:0100646)2.10854358
62Combined immunodeficiency (HP:0005387)2.10201469
63Exercise intolerance (HP:0003546)2.08410297
64Hyperinsulinemic hypoglycemia (HP:0000825)2.06023012
65Median cleft lip (HP:0000161)2.03938414
66Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.03338498
67Dicarboxylic aciduria (HP:0003215)2.00903412
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00903412
69Congenital ichthyosiform erythroderma (HP:0007431)1.99791363
70Bile duct proliferation (HP:0001408)1.99298390
71Abnormal biliary tract physiology (HP:0012439)1.99298390
72Abnormality of the renal medulla (HP:0100957)1.96253997
73Eosinophilia (HP:0001880)1.95847167
74Increased muscle lipid content (HP:0009058)1.95153174
75Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94146178
76Renal cortical cysts (HP:0000803)1.89557875
77Ketosis (HP:0001946)1.89026384
78Pancytopenia (HP:0001876)1.88404228
79Abnormality of the renal cortex (HP:0011035)1.87923193
80Stomatitis (HP:0010280)1.87794384
81Hypoglycemic seizures (HP:0002173)1.87754307
82Abnormality of alanine metabolism (HP:0010916)1.87449624
83Hyperalaninemia (HP:0003348)1.87449624
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87449624
85Renal Fanconi syndrome (HP:0001994)1.87177283
86Chronic sinusitis (HP:0011109)1.86275059
87Methylmalonic aciduria (HP:0012120)1.85927818
88Hypoglycemic coma (HP:0001325)1.85339566
89Degeneration of anterior horn cells (HP:0002398)1.85314422
90Abnormality of the anterior horn cell (HP:0006802)1.85314422
91Ketoacidosis (HP:0001993)1.85138361
92Aplasia/Hypoplasia involving the musculature (HP:0001460)1.85018284
93Tetraplegia (HP:0002445)1.84723088
94Type 2 muscle fiber atrophy (HP:0003554)1.84220877
95CNS demyelination (HP:0007305)1.84161240
96Cystic liver disease (HP:0006706)1.83913872
97Progressive inability to walk (HP:0002505)1.83637830
98Global brain atrophy (HP:0002283)1.83399508
99Medial flaring of the eyebrow (HP:0010747)1.83071541
100Leukodystrophy (HP:0002415)1.83006104

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE13.43506536
2ZAK3.24062206
3TXK3.15076121
4KDR3.13835187
5TRIM282.90829947
6BUB12.61263817
7BCKDK2.48228603
8EIF2AK32.47550368
9ADRBK22.47499270
10MAP4K22.35899667
11MST42.32878122
12MAPKAPK32.19700488
13STK162.16965934
14GRK12.03648702
15PDK22.00871016
16MAP3K121.91745743
17VRK21.85944411
18TESK21.84192989
19MAP2K71.82347043
20NUAK11.71796687
21SRPK11.63455619
22FES1.58928331
23DAPK11.58262454
24FRK1.57000077
25TLK11.51683168
26DAPK21.51447346
27ITK1.45629076
28LIMK11.36641299
29PIK3CG1.35752514
30VRK11.31676263
31TEC1.28359055
32MAP4K11.25454032
33MUSK1.22726136
34PIK3CA1.21978117
35MAP3K41.20214993
36PLK21.19158813
37TAOK31.19115692
38WNK31.09250316
39TSSK61.05082879
40MYLK1.03611061
41ERBB30.99297457
42BMPR1B0.95342603
43TESK10.93785675
44CSNK1G30.92847281
45AKT30.91866154
46KIT0.90267428
47MAP3K60.89270963
48GRK70.88070053
49PHKG20.87557028
50PHKG10.87557028
51PRKCQ0.80379402
52MAP3K50.79744662
53CSNK1A1L0.79679545
54PLK30.79669374
55CSF1R0.79021803
56EIF2AK10.78229724
57CSNK1G10.77456279
58IKBKB0.76416614
59LCK0.76365129
60OXSR10.70096428
61MAPK130.69557028
62FLT30.68888336
63SYK0.66560375
64WNK40.66299262
65MAP2K60.65438800
66INSRR0.64330062
67BCR0.63319258
68CSNK1G20.59758220
69LYN0.54103579
70PIM20.53883570
71CSK0.52907348
72NEK10.51965226
73PRKCE0.49328242
74CSNK2A10.49187566
75CAMK2D0.48999974
76RPS6KA50.48990143
77OBSCN0.46986603
78DYRK20.46742936
79IGF1R0.46469519
80MAP3K110.45575527
81BTK0.45486483
82CAMK2A0.45283068
83NME10.45023038
84ATR0.44665209
85PASK0.42452841
86PRKCA0.40644331
87ADRBK10.39918368
88CSNK1A10.38821858
89EIF2AK20.38335236
90TAF10.38326319
91PRKCG0.37645854
92CAMK2G0.36016853
93SIK30.35583080
94TRPM70.35568386
95MATK0.34896918
96CSNK2A20.34315868
97PIM10.33878228
98PRKACA0.32992214
99IKBKE0.32945577
100SCYL20.30427841

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.24665496
2Oxidative phosphorylation_Homo sapiens_hsa001903.50127604
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.09173328
4Primary immunodeficiency_Homo sapiens_hsa053402.97514915
5Parkinsons disease_Homo sapiens_hsa050122.97440205
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.96679404
7Protein export_Homo sapiens_hsa030602.72450856
8RNA polymerase_Homo sapiens_hsa030202.14996637
9Propanoate metabolism_Homo sapiens_hsa006402.10821877
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.04539945
11Type I diabetes mellitus_Homo sapiens_hsa049402.02183446
12Butanoate metabolism_Homo sapiens_hsa006501.87360396
13Graft-versus-host disease_Homo sapiens_hsa053321.86332335
14Autoimmune thyroid disease_Homo sapiens_hsa053201.81277406
15Allograft rejection_Homo sapiens_hsa053301.81153668
16Fatty acid elongation_Homo sapiens_hsa000621.77469769
17Alzheimers disease_Homo sapiens_hsa050101.75941732
18Steroid biosynthesis_Homo sapiens_hsa001001.73069178
19Huntingtons disease_Homo sapiens_hsa050161.71552505
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71031440
21Caffeine metabolism_Homo sapiens_hsa002321.59320146
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57854851
23Antigen processing and presentation_Homo sapiens_hsa046121.57373798
24Sulfur metabolism_Homo sapiens_hsa009201.52931020
25Rheumatoid arthritis_Homo sapiens_hsa053231.47644727
26Tryptophan metabolism_Homo sapiens_hsa003801.39623585
27RNA degradation_Homo sapiens_hsa030181.38646487
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35242467
29Mismatch repair_Homo sapiens_hsa034301.33377833
30Linoleic acid metabolism_Homo sapiens_hsa005911.31977155
31Basal transcription factors_Homo sapiens_hsa030221.24711041
32Phototransduction_Homo sapiens_hsa047441.19588307
33Collecting duct acid secretion_Homo sapiens_hsa049661.17546611
34Peroxisome_Homo sapiens_hsa041461.17529640
35Hematopoietic cell lineage_Homo sapiens_hsa046401.14821233
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11764829
37Cardiac muscle contraction_Homo sapiens_hsa042601.08141381
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00748486
39Homologous recombination_Homo sapiens_hsa034400.97832050
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97417505
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97121624
42Pyrimidine metabolism_Homo sapiens_hsa002400.97083663
43Spliceosome_Homo sapiens_hsa030400.95365600
44Maturity onset diabetes of the young_Homo sapiens_hsa049500.92879980
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90991535
46Purine metabolism_Homo sapiens_hsa002300.90013482
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88513919
48One carbon pool by folate_Homo sapiens_hsa006700.83878047
49Nitrogen metabolism_Homo sapiens_hsa009100.83036016
50RNA transport_Homo sapiens_hsa030130.80227729
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79736001
52Nucleotide excision repair_Homo sapiens_hsa034200.79544080
53Pyruvate metabolism_Homo sapiens_hsa006200.78654482
54Regulation of autophagy_Homo sapiens_hsa041400.77937792
55Fatty acid degradation_Homo sapiens_hsa000710.77161346
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.74873238
57Retinol metabolism_Homo sapiens_hsa008300.72862900
58Ribosome_Homo sapiens_hsa030100.71181375
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68265772
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67599911
61DNA replication_Homo sapiens_hsa030300.67593056
62Fatty acid metabolism_Homo sapiens_hsa012120.66859333
63Chemical carcinogenesis_Homo sapiens_hsa052040.66607184
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66254406
65beta-Alanine metabolism_Homo sapiens_hsa004100.65959879
66T cell receptor signaling pathway_Homo sapiens_hsa046600.65684536
67Metabolic pathways_Homo sapiens_hsa011000.65678288
68Asthma_Homo sapiens_hsa053100.64678246
69Selenocompound metabolism_Homo sapiens_hsa004500.62616777
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.62608047
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59932485
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57355525
73Arachidonic acid metabolism_Homo sapiens_hsa005900.57300518
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56286212
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.53803945
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51041028
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.50068812
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.49672830
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49248214
80Taste transduction_Homo sapiens_hsa047420.48789525
81Fanconi anemia pathway_Homo sapiens_hsa034600.48596388
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48186540
83Ether lipid metabolism_Homo sapiens_hsa005650.48171962
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47286166
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46104552
86Non-homologous end-joining_Homo sapiens_hsa034500.46061811
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45901136
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45349958
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40935484
90Carbon metabolism_Homo sapiens_hsa012000.40502865
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39651277
92Salmonella infection_Homo sapiens_hsa051320.39046559
93Measles_Homo sapiens_hsa051620.36196932
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35280422
95Fat digestion and absorption_Homo sapiens_hsa049750.32563565
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31516153
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29555946
98Glutathione metabolism_Homo sapiens_hsa004800.28145764
99Viral myocarditis_Homo sapiens_hsa054160.27048411
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26012758

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