PSMC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)6.11088160
2* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.84426994
3cullin deneddylation (GO:0010388)4.82608435
4* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.72094292
5* regulation of cellular amino acid metabolic process (GO:0006521)4.65218540
6* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.58053871
7* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.53208726
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.52774674
9establishment of integrated proviral latency (GO:0075713)4.52624673
10* negative regulation of ligase activity (GO:0051352)4.41439572
11* negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.41439572
12protein deneddylation (GO:0000338)4.36523339
13* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.30013432
14* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.27033661
15* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.27033661
16* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.27033661
17* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.23727004
18* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.23727004
19purine nucleobase biosynthetic process (GO:0009113)4.22434105
20regulation of mitochondrial translation (GO:0070129)4.20775089
21* signal transduction involved in DNA integrity checkpoint (GO:0072401)4.20298201
22* signal transduction involved in DNA damage checkpoint (GO:0072422)4.20298201
23* signal transduction involved in cell cycle checkpoint (GO:0072395)4.15402693
24rRNA modification (GO:0000154)4.09662975
25* positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.09250797
267-methylguanosine mRNA capping (GO:0006370)4.08652874
27nucleobase biosynthetic process (GO:0046112)4.06563578
28energy coupled proton transport, down electrochemical gradient (GO:0015985)4.04367389
29ATP synthesis coupled proton transport (GO:0015986)4.04367389
30L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.03841081
31transcription elongation from RNA polymerase III promoter (GO:0006385)4.02127005
32termination of RNA polymerase III transcription (GO:0006386)4.02127005
337-methylguanosine RNA capping (GO:0009452)4.00501341
34RNA capping (GO:0036260)4.00501341
35protein neddylation (GO:0045116)3.99613950
36* positive regulation of ligase activity (GO:0051351)3.90513696
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.89169936
38formation of translation preinitiation complex (GO:0001731)3.85801919
39ribosome assembly (GO:0042255)3.82779072
40establishment of viral latency (GO:0019043)3.80792736
41L-methionine salvage (GO:0071267)3.79887994
42L-methionine biosynthetic process (GO:0071265)3.79887994
43amino acid salvage (GO:0043102)3.79887994
44DNA strand elongation (GO:0022616)3.75522447
45* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.71723390
46telomere maintenance via semi-conservative replication (GO:0032201)3.70523279
47transcription elongation from RNA polymerase I promoter (GO:0006362)3.61682083
48deoxyribonucleotide biosynthetic process (GO:0009263)3.60090731
49* regulation of ubiquitin-protein transferase activity (GO:0051438)3.58734379
50termination of RNA polymerase I transcription (GO:0006363)3.51337570
51respiratory electron transport chain (GO:0022904)3.49873139
52metaphase plate congression (GO:0051310)3.48722433
53* regulation of cellular amine metabolic process (GO:0033238)3.47308557
54mitotic metaphase plate congression (GO:0007080)3.45513247
55ribosome biogenesis (GO:0042254)3.45318624
56* regulation of ligase activity (GO:0051340)3.45257999
57* positive regulation of cell cycle arrest (GO:0071158)3.40547397
58IMP biosynthetic process (GO:0006188)3.40517881
59electron transport chain (GO:0022900)3.40144957
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.39425903
61rRNA methylation (GO:0031167)3.38799930
62* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.38572669
63* negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.36976974
64transcription from RNA polymerase I promoter (GO:0006360)3.32074096
65maturation of 5.8S rRNA (GO:0000460)3.30672470
66* DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.30283517
67microtubule depolymerization (GO:0007019)3.28966450
68CENP-A containing nucleosome assembly (GO:0034080)3.26369488
69DNA replication checkpoint (GO:0000076)3.25850949
70guanosine-containing compound biosynthetic process (GO:1901070)3.24060761
71* G1/S transition of mitotic cell cycle (GO:0000082)3.23217292
72* cell cycle G1/S phase transition (GO:0044843)3.23217292
73spliceosomal snRNP assembly (GO:0000387)3.21119043
74maturation of SSU-rRNA (GO:0030490)3.18733570
75transcription-coupled nucleotide-excision repair (GO:0006283)3.18389956
76ribosomal large subunit biogenesis (GO:0042273)3.18123105
77chromatin remodeling at centromere (GO:0031055)3.17173554
78protein-cofactor linkage (GO:0018065)3.17083478
79transcription initiation from RNA polymerase I promoter (GO:0006361)3.14228454
80DNA replication initiation (GO:0006270)3.12868357
81telomere maintenance via recombination (GO:0000722)3.12139719
82* signal transduction in response to DNA damage (GO:0042770)3.12010395
83pseudouridine synthesis (GO:0001522)3.12002248
84methionine biosynthetic process (GO:0009086)3.11749785
85protein maturation by protein folding (GO:0022417)3.10858599
86tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.10435012
87RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.10435012
88establishment of protein localization to mitochondrion (GO:0072655)3.09084766
89tRNA aminoacylation for protein translation (GO:0006418)3.07083122
90tricarboxylic acid cycle (GO:0006099)3.06994595
91protein localization to mitochondrion (GO:0070585)3.06168348
92mitotic recombination (GO:0006312)3.06104469
93nucleobase-containing small molecule interconversion (GO:0015949)3.05657995
94blastocyst development (GO:0001824)3.04321896
95oxidative phosphorylation (GO:0006119)3.03553337
96chaperone-mediated protein transport (GO:0072321)3.02477373
97DNA damage response, detection of DNA damage (GO:0042769)3.02199879
98ribonucleoprotein complex biogenesis (GO:0022613)3.01874716
99tRNA aminoacylation (GO:0043039)3.01573326
100amino acid activation (GO:0043038)3.01573326
101transcription elongation from RNA polymerase II promoter (GO:0006368)3.01541168
102* antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.01210221
103de novo protein folding (GO:0006458)3.00638932
104IMP metabolic process (GO:0046040)3.00367327
105* negative regulation of cell cycle G1/S phase transition (GO:1902807)2.99928966
106* negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.99928966
107mitotic sister chromatid segregation (GO:0000070)2.99836001
108pteridine-containing compound biosynthetic process (GO:0042559)2.99619797
109mitochondrial respiratory chain complex I assembly (GO:0032981)2.99283486
110NADH dehydrogenase complex assembly (GO:0010257)2.99283486
111mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99283486
112GTP biosynthetic process (GO:0006183)2.99160339
113protein targeting to mitochondrion (GO:0006626)2.98425680
114rRNA processing (GO:0006364)2.97706571
115* negative regulation of protein ubiquitination (GO:0031397)2.97240473
116* regulation of cell cycle arrest (GO:0071156)2.97001534
117DNA catabolic process, exonucleolytic (GO:0000738)2.96949052
118protein complex biogenesis (GO:0070271)2.96526982
119regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.95733331
120mitochondrial respiratory chain complex assembly (GO:0033108)2.94831027
121de novo posttranslational protein folding (GO:0051084)2.93549362
122inner mitochondrial membrane organization (GO:0007007)2.93235818
123deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.93122019
124DNA strand elongation involved in DNA replication (GO:0006271)2.90027101
125DNA ligation (GO:0006266)2.89593789
126histone exchange (GO:0043486)2.89241814
127DNA-templated transcription, elongation (GO:0006354)2.89032065
128telomere maintenance via telomere lengthening (GO:0010833)2.88898892
129* positive regulation of protein ubiquitination (GO:0031398)2.86040196

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.97244064
2E2F7_22180533_ChIP-Seq_HELA_Human4.36441097
3* GABP_17652178_ChIP-ChIP_JURKAT_Human4.06207557
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.03430177
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.00076517
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.76173736
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.63657162
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.59383562
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.52254321
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.36945570
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.27932441
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.97596791
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86056946
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.85034062
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.84030364
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.77187981
17* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69201911
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.63638494
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58687908
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51086049
21* VDR_23849224_ChIP-Seq_CD4+_Human2.38527375
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.30200676
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.27300969
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.25151587
25DCP1A_22483619_ChIP-Seq_HELA_Human2.20339915
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.19442593
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11767574
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10452434
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09156521
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05512055
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01395617
32* FOXP3_21729870_ChIP-Seq_TREG_Human1.97302526
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94761282
34* ELK1_19687146_ChIP-ChIP_HELA_Human1.93695002
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92354339
36GABP_19822575_ChIP-Seq_HepG2_Human1.87309519
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86361528
38XRN2_22483619_ChIP-Seq_HELA_Human1.80829029
39TTF2_22483619_ChIP-Seq_HELA_Human1.77714632
40AR_21909140_ChIP-Seq_LNCAP_Human1.73048523
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72567137
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72554258
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70027515
44* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67672363
45* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55624336
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54829858
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52387730
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.49432198
49* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45936452
50* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44108579
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.42053249
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40510831
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38179405
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.32367296
55ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.31505823
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.22195580
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21523008
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17397635
59IRF1_19129219_ChIP-ChIP_H3396_Human1.16255686
60MYC_18940864_ChIP-ChIP_HL60_Human1.12112965
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10975116
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09838397
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07311706
64FUS_26573619_Chip-Seq_HEK293_Human1.07163017
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06066371
66SOX17_20123909_ChIP-Seq_XEN_Mouse1.04527237
67VDR_22108803_ChIP-Seq_LS180_Human1.04274919
68DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03146026
69* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02182906
70KDM5A_27292631_Chip-Seq_BREAST_Human1.01483445
71KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98865649
72ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98792630
73ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97714157
74E2F1_21310950_ChIP-Seq_MCF-7_Human0.97125644
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94269367
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93558495
77PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92840181
78NFE2_27457419_Chip-Seq_LIVER_Mouse0.92768229
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92082409
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91587882
81NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91283929
82SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90798803
83* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89675975
84SALL1_21062744_ChIP-ChIP_HESCs_Human0.88396649
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87976095
86SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87972611
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86994330
88KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85988223
89CIITA_25753668_ChIP-Seq_RAJI_Human0.85513040
90ELF5_23300383_ChIP-Seq_T47D_Human0.84925592
91CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84654695
92EWS_26573619_Chip-Seq_HEK293_Human0.83558270
93ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.83517695
94TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82951668
95ZNF263_19887448_ChIP-Seq_K562_Human0.82590108
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81947749
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.81723463
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81488854
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81324738
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.79320379
101CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.78862285
102TFEB_21752829_ChIP-Seq_HELA_Human0.78519144
103PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.77962685
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77492793
105* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.75348341
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.74838075
107BMI1_23680149_ChIP-Seq_NPCS_Mouse0.73913563
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73392471
109POU5F1_16153702_ChIP-ChIP_HESCs_Human0.73346815
110HTT_18923047_ChIP-ChIP_STHdh_Human0.72542950
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.71504492
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.71465519
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.70321814
114CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.70048252
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.69010833
116* NANOG_16153702_ChIP-ChIP_HESCs_Human0.66738716
117CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.66044037
118* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.64661440
119SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.64597374
120* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.63801191
121NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.63745146
122STAT3_1855785_ChIP-Seq_MESCs_Mouse0.62676753
123ERG_20887958_ChIP-Seq_HPC-7_Mouse0.62255614
124TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.61344301

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.85318578
2MP0008058_abnormal_DNA_repair3.68715264
3MP0003111_abnormal_nucleus_morphology3.57325971
4MP0004957_abnormal_blastocyst_morpholog3.53094555
5MP0010094_abnormal_chromosome_stability3.43113038
6MP0008877_abnormal_DNA_methylation3.19582643
7MP0003718_maternal_effect2.98443662
8MP0008932_abnormal_embryonic_tissue2.73352462
9MP0008057_abnormal_DNA_replication2.72198297
10MP0008260_abnormal_autophagy2.72123875
11MP0003077_abnormal_cell_cycle2.64113892
12MP0003806_abnormal_nucleotide_metabolis2.62704890
13MP0003786_premature_aging2.49145204
14MP0001529_abnormal_vocalization2.24367029
15MP0005410_abnormal_fertilization2.11539198
16MP0009697_abnormal_copulation2.03387884
17MP0002877_abnormal_melanocyte_morpholog1.98239569
18MP0001188_hyperpigmentation1.92598829
19MP0003123_paternal_imprinting1.79023276
20MP0002160_abnormal_reproductive_system1.71622244
21MP0006036_abnormal_mitochondrial_physio1.69863845
22MP0006035_abnormal_mitochondrial_morpho1.69592512
23MP0008007_abnormal_cellular_replicative1.68574251
24MP0005408_hypopigmentation1.65333340
25MP0002210_abnormal_sex_determination1.64638456
26MP0006276_abnormal_autonomic_nervous1.64406224
27MP0002653_abnormal_ependyma_morphology1.61125567
28MP0001542_abnormal_bone_strength1.59342942
29MP0001929_abnormal_gametogenesis1.56972138
30MP0002163_abnormal_gland_morphology1.55878292
31MP0001905_abnormal_dopamine_level1.53613712
32MP0001727_abnormal_embryo_implantation1.48913489
33MP0001853_heart_inflammation1.46713367
34MP0002876_abnormal_thyroid_physiology1.44255772
35MP0003698_abnormal_male_reproductive1.43394866
36MP0003186_abnormal_redox_activity1.41769093
37MP0003195_calcinosis1.38099989
38MP0005389_reproductive_system_phenotype1.37549901
39MP0002102_abnormal_ear_morphology1.35662360
40MP0001986_abnormal_taste_sensitivity1.34892844
41MP0001145_abnormal_male_reproductive1.33057175
42MP0003315_abnormal_perineum_morphology1.30113976
43MP0002735_abnormal_chemical_nociception1.29515776
44MP0001661_extended_life_span1.29075756
45MP0002638_abnormal_pupillary_reflex1.25979719
46MP0004147_increased_porphyrin_level1.25876543
47MP0001730_embryonic_growth_arrest1.25160774
48MP0000647_abnormal_sebaceous_gland1.21918897
49MP0010307_abnormal_tumor_latency1.20049680
50MP0010234_abnormal_vibrissa_follicle1.17001338
51MP0003136_yellow_coat_color1.16764769
52MP0000653_abnormal_sex_gland1.15569031
53MP0006292_abnormal_olfactory_placode1.13807894
54MP0003941_abnormal_skin_development1.12230275
55MP0001764_abnormal_homeostasis1.11366535
56MP0002736_abnormal_nociception_after1.11321597
57MP0001881_abnormal_mammary_gland1.11069341
58MP0005395_other_phenotype1.09694769
59MP0003950_abnormal_plasma_membrane1.09660097
60MP0002090_abnormal_vision1.06434083
61MP0005075_abnormal_melanosome_morpholog1.05454970
62MP0000749_muscle_degeneration1.04745712
63MP0000358_abnormal_cell_content/1.04503618
64MP0004142_abnormal_muscle_tone1.03165755
65MP0005171_absent_coat_pigmentation1.03121111
66MP0005332_abnormal_amino_acid1.01565048
67MP0002019_abnormal_tumor_incidence1.01512297
68MP0002751_abnormal_autonomic_nervous1.01292264
69MP0001919_abnormal_reproductive_system1.01112067
70MP0005451_abnormal_body_composition1.01079140
71MP0004233_abnormal_muscle_weight1.00979334
72MP0008789_abnormal_olfactory_epithelium1.00164168
73MP0005330_cardiomyopathy0.96404887
74MP0002837_dystrophic_cardiac_calcinosis0.96310705
75MP0001243_abnormal_dermal_layer0.95348246
76MP0002132_abnormal_respiratory_system0.92594253
77MP0008875_abnormal_xenobiotic_pharmacok0.92435133
78MP0000350_abnormal_cell_proliferation0.91423962
79MP0005501_abnormal_skin_physiology0.89284688
80MP0003646_muscle_fatigue0.88190013
81MP0010352_gastrointestinal_tract_polyps0.87809782
82MP0006054_spinal_hemorrhage0.87338667
83MP0003984_embryonic_growth_retardation0.86966440
84MP0000566_synostosis0.86570251
85MP0005084_abnormal_gallbladder_morpholo0.86337776
86MP0000750_abnormal_muscle_regeneration0.86282911
87MP0002095_abnormal_skin_pigmentation0.84499021
88MP0002277_abnormal_respiratory_mucosa0.83575691
89MP0002088_abnormal_embryonic_growth/wei0.83554795
90MP0002161_abnormal_fertility/fecundity0.83050678
91MP0002060_abnormal_skin_morphology0.82151295
92MP0002080_prenatal_lethality0.81023918
93MP0009333_abnormal_splenocyte_physiolog0.80139456
94MP0001440_abnormal_grooming_behavior0.79791226
95MP0001968_abnormal_touch/_nociception0.78989390
96MP0005384_cellular_phenotype0.78755559
97MP0004133_heterotaxia0.77968978
98MP0002269_muscular_atrophy0.77632487
99MP0004215_abnormal_myocardial_fiber0.76964891
100MP0002084_abnormal_developmental_patter0.76745227
101MP0009046_muscle_twitch0.76737679
102MP0003221_abnormal_cardiomyocyte_apopto0.76604599
103MP0001672_abnormal_embryogenesis/_devel0.76431584
104MP0005380_embryogenesis_phenotype0.76431584
105MP0002938_white_spotting0.76218296
106MP0001697_abnormal_embryo_size0.75156980
107MP0003121_genomic_imprinting0.74787264
108MP0005379_endocrine/exocrine_gland_phen0.74372533
109MP0005503_abnormal_tendon_morphology0.73921425
110MP0000372_irregular_coat_pigmentation0.73734861
111MP0001293_anophthalmia0.72342970
112MP0001984_abnormal_olfaction0.72245788
113MP0000627_abnormal_mammary_gland0.71539372
114MP0010030_abnormal_orbit_morphology0.71156334
115MP0005636_abnormal_mineral_homeostasis0.69864786
116MP0000313_abnormal_cell_death0.69154145
117MP0010386_abnormal_urinary_bladder0.68277188
118MP0008873_increased_physiological_sensi0.67028014
119MP0005266_abnormal_metabolism0.66817974
120MP0002734_abnormal_mechanical_nocicepti0.66773804
121MP0005670_abnormal_white_adipose0.65991905
122MP0006072_abnormal_retinal_apoptosis0.65891993
123MP0005646_abnormal_pituitary_gland0.64784697
124MP0002177_abnormal_outer_ear0.64536355
125MP0005165_increased_susceptibility_to0.64474492
126MP0003937_abnormal_limbs/digits/tail_de0.63063748
127MP0003890_abnormal_embryonic-extraembry0.62651407
128MP0009672_abnormal_birth_weight0.61642843
129MP0000427_abnormal_hair_cycle0.61491049
130MP0002085_abnormal_embryonic_tissue0.61378958
131MP0008004_abnormal_stomach_pH0.60839023
132MP0002086_abnormal_extraembryonic_tissu0.60266632
133MP0005319_abnormal_enzyme/_coenzyme0.59826494
134MP0002111_abnormal_tail_morphology0.59731728
135MP0001216_abnormal_epidermal_layer0.58881976
136MP0001963_abnormal_hearing_physiology0.58754294
137MP0003011_delayed_dark_adaptation0.55879578
138MP0001119_abnormal_female_reproductive0.54591559
139MP0003656_abnormal_erythrocyte_physiolo0.53986000
140MP0005253_abnormal_eye_physiology0.53646490
141MP0001186_pigmentation_phenotype0.53284231
142MP0002796_impaired_skin_barrier0.51468469

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.90104134
2Abnormal mitochondria in muscle tissue (HP:0008316)4.37905408
3Increased serum pyruvate (HP:0003542)4.26441434
4Abnormality of glycolysis (HP:0004366)4.26441434
5Birth length less than 3rd percentile (HP:0003561)4.20013004
6Cerebral hypomyelination (HP:0006808)4.01331514
7Mitochondrial inheritance (HP:0001427)3.94252495
8Progressive macrocephaly (HP:0004481)3.90824233
9Increased CSF lactate (HP:0002490)3.84175996
10Acute encephalopathy (HP:0006846)3.78466762
11Microvesicular hepatic steatosis (HP:0001414)3.58591880
12Abnormality of methionine metabolism (HP:0010901)3.44784110
13Hepatocellular necrosis (HP:0001404)3.25353614
14Increased intramyocellular lipid droplets (HP:0012240)3.17887259
15Abnormal protein glycosylation (HP:0012346)3.15060201
16Abnormal glycosylation (HP:0012345)3.15060201
17Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.15060201
18Abnormal protein N-linked glycosylation (HP:0012347)3.15060201
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.11521413
20Breast hypoplasia (HP:0003187)3.06842647
21Reduced antithrombin III activity (HP:0001976)3.00739128
22Hepatic necrosis (HP:0002605)3.00718206
23Increased serum lactate (HP:0002151)3.00578815
24Increased hepatocellular lipid droplets (HP:0006565)2.97974954
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.93580893
26Abnormality of alanine metabolism (HP:0010916)2.93580893
27Hyperalaninemia (HP:0003348)2.93580893
28Cerebral edema (HP:0002181)2.93523675
29Chromsome breakage (HP:0040012)2.89623145
30Upper limb muscle weakness (HP:0003484)2.79823537
31Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.75402807
32Carpal bone hypoplasia (HP:0001498)2.73403470
33Hypoplasia of the capital femoral epiphysis (HP:0003090)2.71891864
34Exercise intolerance (HP:0003546)2.71398872
353-Methylglutaconic aciduria (HP:0003535)2.69018355
36Lactic acidosis (HP:0003128)2.65671937
37Lipid accumulation in hepatocytes (HP:0006561)2.59793697
38Abnormality of aspartate family amino acid metabolism (HP:0010899)2.56594855
39Increased muscle lipid content (HP:0009058)2.56190283
40Sparse eyelashes (HP:0000653)2.55419843
41Methylmalonic acidemia (HP:0002912)2.53753999
42Rough bone trabeculation (HP:0100670)2.52523441
43Aplastic anemia (HP:0001915)2.51484882
44Hypokinesia (HP:0002375)2.49170938
45Multiple enchondromatosis (HP:0005701)2.47337270
46Abnormality of the labia minora (HP:0012880)2.45644099
47Leukodystrophy (HP:0002415)2.44273777
48Absent radius (HP:0003974)2.41574076
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40986554
50Respiratory failure (HP:0002878)2.40043295
51Irregular epiphyses (HP:0010582)2.38860477
52Pancytopenia (HP:0001876)2.38032743
53Abnormal gallbladder physiology (HP:0012438)2.37713212
54Cholecystitis (HP:0001082)2.37713212
55CNS hypomyelination (HP:0003429)2.37175781
56Abnormality of the preputium (HP:0100587)2.36366264
57Optic disc pallor (HP:0000543)2.36015888
58Decreased activity of mitochondrial respiratory chain (HP:0008972)2.35796520
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.35796520
60Facial cleft (HP:0002006)2.35357448
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34785170
62CNS demyelination (HP:0007305)2.32587001
63Meckel diverticulum (HP:0002245)2.32074049
64Methylmalonic aciduria (HP:0012120)2.31078552
65Aplasia involving forearm bones (HP:0009822)2.28463498
66Absent forearm bone (HP:0003953)2.28463498
67Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.25010817
68Absent epiphyses (HP:0010577)2.25010817
69Impulsivity (HP:0100710)2.23795987
70Abnormality of serum amino acid levels (HP:0003112)2.21148742
71Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.19815291
72Respiratory difficulties (HP:0002880)2.18976731
73Abnormal spermatogenesis (HP:0008669)2.18798148
74Duplicated collecting system (HP:0000081)2.17317736
75Abnormality of the ileum (HP:0001549)2.16711887
76Secondary amenorrhea (HP:0000869)2.16170138
77Medial flaring of the eyebrow (HP:0010747)2.15425756
78Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15306365
79Abnormality of chromosome stability (HP:0003220)2.15115689
80Delusions (HP:0000746)2.14199446
81Prolonged neonatal jaundice (HP:0006579)2.13523880
82Oral leukoplakia (HP:0002745)2.13279686
83Exertional dyspnea (HP:0002875)2.13041883
84Ureteral duplication (HP:0000073)2.09444474
85Patellar aplasia (HP:0006443)2.07687187
86Hypoglycemic coma (HP:0001325)2.07539439
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.05936706
88Horseshoe kidney (HP:0000085)2.04397354
89Abnormal respiratory motile cilium morphology (HP:0005938)2.03398504
90Abnormal respiratory epithelium morphology (HP:0012253)2.03398504
91Pancreatic fibrosis (HP:0100732)2.03104101
92Generalized aminoaciduria (HP:0002909)2.01660612
93Congenital ichthyosiform erythroderma (HP:0007431)2.01181166
94Palpitations (HP:0001962)2.00389972
95Aplasia/Hypoplasia of the patella (HP:0006498)1.99297699
96Aplasia/Hypoplasia involving the musculature (HP:0001460)1.97820374
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.97462149
98Abnormal trabecular bone morphology (HP:0100671)1.97168145
99Neoplasm of the adrenal gland (HP:0100631)1.96590690
100Dynein arm defect of respiratory motile cilia (HP:0012255)1.95942378
101Absent/shortened dynein arms (HP:0200106)1.95942378
102Progressive muscle weakness (HP:0003323)1.95129337
103Autoamputation (HP:0001218)1.94438242
104Degeneration of anterior horn cells (HP:0002398)1.93708037
105Abnormality of the anterior horn cell (HP:0006802)1.93708037
106Abnormalities of placenta or umbilical cord (HP:0001194)1.92874742
107Adrenal hypoplasia (HP:0000835)1.92316212
108Renal Fanconi syndrome (HP:0001994)1.92198328
109Aplasia/hypoplasia of the uterus (HP:0008684)1.92129131
110Type I transferrin isoform profile (HP:0003642)1.92103320
111Nausea (HP:0002018)1.91757203
112Congenital primary aphakia (HP:0007707)1.90790709
113Amniotic constriction ring (HP:0009775)1.90672097
114Abnormality of placental membranes (HP:0011409)1.90672097
115Opisthotonus (HP:0002179)1.90137197
116Dicarboxylic aciduria (HP:0003215)1.89345209
117Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89345209
118Entropion (HP:0000621)1.89095226
119Abnormality of aromatic amino acid family metabolism (HP:0004338)1.88949102
120Reduced subcutaneous adipose tissue (HP:0003758)1.88692540
121Megaloblastic anemia (HP:0001889)1.87641821
122Lethargy (HP:0001254)1.87640595
123Unsteady gait (HP:0002317)1.87367852
124Pancreatic cysts (HP:0001737)1.86950760
125Postnatal microcephaly (HP:0005484)1.86095515
126Ependymoma (HP:0002888)1.85228115
127Emotional lability (HP:0000712)1.84335749
128Abnormality of the umbilical cord (HP:0010881)1.83839375
129Abnormality of the renal collecting system (HP:0004742)1.82551192
130Trismus (HP:0000211)1.81067223
131Macrocytic anemia (HP:0001972)1.81059334
132Poor head control (HP:0002421)1.81048127
133X-linked dominant inheritance (HP:0001423)1.80899414
134Nephrogenic diabetes insipidus (HP:0009806)1.80529304
135Hypothermia (HP:0002045)1.78869247
136Premature ovarian failure (HP:0008209)1.78554064
137Gait imbalance (HP:0002141)1.78530155
138Spastic paraparesis (HP:0002313)1.77149863
139Progressive external ophthalmoplegia (HP:0000590)1.76903692
140Duodenal stenosis (HP:0100867)1.76761898
141Small intestinal stenosis (HP:0012848)1.76761898
142Shoulder girdle muscle weakness (HP:0003547)1.75858854
143Myelodysplasia (HP:0002863)1.75189731
144Parakeratosis (HP:0001036)1.74465996
145Abnormal lung lobation (HP:0002101)1.74069264
146Ragged-red muscle fibers (HP:0003200)1.73628094
147Rhabdomyolysis (HP:0003201)1.72872604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.75032673
2STK164.07965956
3EIF2AK13.73493075
4VRK23.24708819
5WEE13.09857913
6TSSK63.08615447
7PDK32.68904831
8PDK42.68904831
9PLK42.68050622
10CASK2.66986142
11SRPK12.53755214
12EPHA22.34241146
13EIF2AK32.33678690
14SCYL22.31570283
15PNCK2.17200664
16NME12.13020605
17PDK22.10591837
18TRIM282.08385848
19AKT31.88267956
20ZAK1.81579541
21PLK31.80690737
22CCNB11.78704948
23CDC71.69338368
24TTK1.64531559
25EIF2AK21.60663134
26NEK11.55711330
27BCR1.55267899
28BRSK21.52723500
29PLK11.50376042
30STK38L1.49200907
31NME21.37408238
32PBK1.37320003
33PAK41.36616379
34VRK11.32790658
35PLK21.32514879
36BRAF1.29907791
37NUAK11.22744740
38TESK21.16376317
39AURKA1.16354809
40MKNK11.16273749
41IRAK31.14248672
42MST1R1.14062764
43LIMK11.12466688
44MAP4K21.10296478
45TESK11.08878597
46CLK11.02044893
47DAPK10.97299081
48AURKB0.96437603
49MKNK20.95475137
50PASK0.93382132
51BRSK10.92324630
52MST40.91440513
53KDR0.87316641
54DYRK20.86147394
55DYRK30.86103618
56ATR0.85577857
57CHEK20.82125258
58ABL20.81071241
59TAF10.80552481
60ARAF0.79700370
61ACVR1B0.78189383
62NEK20.77753834
63GRK70.74056487
64STK100.73962192
65CSNK1G10.72238908
66CSNK2A10.67763986
67ALK0.66091397
68CSNK2A20.63668151
69CHEK10.61281552
70GRK10.61170766
71PIM20.60991811
72OBSCN0.60914423
73ADRBK20.60744029
74PRKCG0.60392010
75CSNK1A1L0.59899679
76YES10.58222076
77WNK30.58204979
78BMPR1B0.57704215
79PRKCI0.56223243
80TLK10.56182439
81STK40.55140379
82PAK10.55093981
83ILK0.54531690
84MAP3K80.54057053
85CSNK1G20.51120563
86PIK3CG0.50893864
87MAP3K120.50708547
88RPS6KB20.50395153
89MAP2K70.49175915
90ERBB40.48754569
91MET0.44441008
92OXSR10.44117985
93CDK70.43163139
94CDK80.39141465
95MYLK0.38063348
96ATM0.37599197
97CSNK1E0.37412597
98FLT30.37166091
99SIK30.36739382
100CDK10.35225299
101CDK30.35148203
102MAPKAPK30.34903976
103PHKG20.33078190
104PHKG10.33078190
105ERBB30.32849529
106CAMK2G0.32833049
107CAMK2B0.32460161
108IRAK20.32253425
109MARK10.30925532
110CAMKK20.30366433
111CSNK1G30.30252470
112AKT20.29636070
113TAOK20.29540328
114RPS6KA50.29173737
115BCKDK0.29165452
116IRAK10.28360524
117PRKCE0.28250815
118CDK20.28230343
119CDK180.27869710
120NEK60.26474379
121INSRR0.26403601
122DAPK30.26256674
123RPS6KA40.25155368
124RAF10.25072273
125CAMK2D0.23932080
126MAP3K40.23909277
127NTRK30.23704503
128MINK10.23608470
129CDK140.23447570
130FGFR10.23237966
131STK240.23006857
132ADRBK10.22957545
133CDK150.20966852

Predicted pathways (KEGG)

RankGene SetZ-score
1* Proteasome_Homo sapiens_hsa030505.69005229
2RNA polymerase_Homo sapiens_hsa030203.74208442
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.32085551
4Oxidative phosphorylation_Homo sapiens_hsa001903.22010137
5DNA replication_Homo sapiens_hsa030302.70538539
6Mismatch repair_Homo sapiens_hsa034302.66965428
7Parkinsons disease_Homo sapiens_hsa050122.62749977
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.59623611
9RNA transport_Homo sapiens_hsa030132.48159772
10Pyrimidine metabolism_Homo sapiens_hsa002402.41167645
11Ribosome_Homo sapiens_hsa030102.38786916
12Huntingtons disease_Homo sapiens_hsa050162.26625066
13Nucleotide excision repair_Homo sapiens_hsa034202.23885635
14Homologous recombination_Homo sapiens_hsa034402.22231857
15Vitamin B6 metabolism_Homo sapiens_hsa007502.18714989
16Spliceosome_Homo sapiens_hsa030402.15365095
17Basal transcription factors_Homo sapiens_hsa030222.10447540
18Protein export_Homo sapiens_hsa030601.90830683
19Fanconi anemia pathway_Homo sapiens_hsa034601.82562054
20Collecting duct acid secretion_Homo sapiens_hsa049661.74639199
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73874391
22One carbon pool by folate_Homo sapiens_hsa006701.68601873
23Alzheimers disease_Homo sapiens_hsa050101.67748197
24Base excision repair_Homo sapiens_hsa034101.63613309
25Purine metabolism_Homo sapiens_hsa002301.62596274
26Non-homologous end-joining_Homo sapiens_hsa034501.62368999
27Cell cycle_Homo sapiens_hsa041101.52955874
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.41949707
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39381972
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.34212459
31Regulation of autophagy_Homo sapiens_hsa041401.31861313
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23975190
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.21459415
34Sulfur metabolism_Homo sapiens_hsa009201.19884362
35Pyruvate metabolism_Homo sapiens_hsa006201.08049210
36RNA degradation_Homo sapiens_hsa030181.06993809
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05900819
38* Epstein-Barr virus infection_Homo sapiens_hsa051691.02747181
39Vibrio cholerae infection_Homo sapiens_hsa051100.95762188
40Glutathione metabolism_Homo sapiens_hsa004800.94865482
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93911755
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92853086
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89891429
44Carbon metabolism_Homo sapiens_hsa012000.88767009
45Fructose and mannose metabolism_Homo sapiens_hsa000510.88508645
46Pentose phosphate pathway_Homo sapiens_hsa000300.87066837
47Fatty acid elongation_Homo sapiens_hsa000620.86775657
48N-Glycan biosynthesis_Homo sapiens_hsa005100.84233411
49mRNA surveillance pathway_Homo sapiens_hsa030150.84009967
50Metabolic pathways_Homo sapiens_hsa011000.81869085
51p53 signaling pathway_Homo sapiens_hsa041150.81072870
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78706530
53Cardiac muscle contraction_Homo sapiens_hsa042600.77466656
54Phenylalanine metabolism_Homo sapiens_hsa003600.76238870
55Steroid biosynthesis_Homo sapiens_hsa001000.75003466
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74932139
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73573240
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.72995009
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70618644
60Folate biosynthesis_Homo sapiens_hsa007900.70001996
61Biosynthesis of amino acids_Homo sapiens_hsa012300.69632318
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69089775
63Arachidonic acid metabolism_Homo sapiens_hsa005900.68579126
64Tyrosine metabolism_Homo sapiens_hsa003500.67236106
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66422378
66Oocyte meiosis_Homo sapiens_hsa041140.65312441
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64783005
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64410534
69Propanoate metabolism_Homo sapiens_hsa006400.64186767
70Fatty acid metabolism_Homo sapiens_hsa012120.62368958
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62345490
72Arginine and proline metabolism_Homo sapiens_hsa003300.59935450
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59129487
74Selenocompound metabolism_Homo sapiens_hsa004500.54525260
75Linoleic acid metabolism_Homo sapiens_hsa005910.52750819
76Synaptic vesicle cycle_Homo sapiens_hsa047210.52653861
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52193462
78Fatty acid degradation_Homo sapiens_hsa000710.52077490
79Galactose metabolism_Homo sapiens_hsa000520.51247017
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46144147
81Phagosome_Homo sapiens_hsa041450.43127511
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42238269
83Vitamin digestion and absorption_Homo sapiens_hsa049770.42118483
84Rheumatoid arthritis_Homo sapiens_hsa053230.41276761
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.41272487
86Tryptophan metabolism_Homo sapiens_hsa003800.35108817
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31889651
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30984147
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30741070
90Phototransduction_Homo sapiens_hsa047440.29981431
91Sphingolipid metabolism_Homo sapiens_hsa006000.29613153
92beta-Alanine metabolism_Homo sapiens_hsa004100.29344459
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.26625747
94Shigellosis_Homo sapiens_hsa051310.25853785
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25115194
96Arginine biosynthesis_Homo sapiens_hsa002200.24905411
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24396213
98Sulfur relay system_Homo sapiens_hsa041220.23342453
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21203126
100Autoimmune thyroid disease_Homo sapiens_hsa053200.20865811
101Nicotine addiction_Homo sapiens_hsa050330.19790836
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19094066
103Caffeine metabolism_Homo sapiens_hsa002320.19034342
104Histidine metabolism_Homo sapiens_hsa003400.18628704
105Butanoate metabolism_Homo sapiens_hsa006500.17375226
106Ether lipid metabolism_Homo sapiens_hsa005650.17162071
107Chemical carcinogenesis_Homo sapiens_hsa052040.16855765
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16370039
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.15897347
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.15128826
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13625444
112Systemic lupus erythematosus_Homo sapiens_hsa053220.13105377
113Antigen processing and presentation_Homo sapiens_hsa046120.12717837
114Peroxisome_Homo sapiens_hsa041460.12147823
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.11616210
116Viral carcinogenesis_Homo sapiens_hsa052030.11206607
117Legionellosis_Homo sapiens_hsa051340.10832686
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.10650441
119Retinol metabolism_Homo sapiens_hsa008300.08931310

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