PSMC3IP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.12909478
2DNA replication checkpoint (GO:0000076)5.03518052
3DNA replication initiation (GO:0006270)4.90597972
4DNA strand elongation (GO:0022616)4.88751117
5telomere maintenance via semi-conservative replication (GO:0032201)4.88095106
6ribosomal small subunit assembly (GO:0000028)4.52252298
7telomere maintenance via recombination (GO:0000722)4.44069633
8viral transcription (GO:0019083)4.33807005
9maturation of SSU-rRNA (GO:0030490)4.31282148
10chromatin remodeling at centromere (GO:0031055)4.29217483
11DNA deamination (GO:0045006)4.26572213
12CENP-A containing nucleosome assembly (GO:0034080)4.24402066
13translational termination (GO:0006415)4.24285112
14establishment of integrated proviral latency (GO:0075713)4.22688161
15ribosomal small subunit biogenesis (GO:0042274)4.21994984
16mitotic recombination (GO:0006312)4.16266335
17ribosomal large subunit biogenesis (GO:0042273)4.09002616
18mitotic metaphase plate congression (GO:0007080)4.07936574
19establishment of protein localization to mitochondrial membrane (GO:0090151)3.93852345
20sister chromatid segregation (GO:0000819)3.92180439
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.90504371
22telomere maintenance via telomere lengthening (GO:0010833)3.90334247
23spliceosomal snRNP assembly (GO:0000387)3.88637874
24mitotic chromosome condensation (GO:0007076)3.86793143
25histone exchange (GO:0043486)3.82813755
26kinetochore organization (GO:0051383)3.80021809
27DNA replication-dependent nucleosome assembly (GO:0006335)3.78442658
28DNA replication-dependent nucleosome organization (GO:0034723)3.78442658
29DNA replication-independent nucleosome organization (GO:0034724)3.77532834
30DNA replication-independent nucleosome assembly (GO:0006336)3.77532834
31proteasome assembly (GO:0043248)3.75625128
32translational elongation (GO:0006414)3.75330481
33regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.73028713
34ribonucleoprotein complex biogenesis (GO:0022613)3.72842521
35nucleotide-excision repair, DNA gap filling (GO:0006297)3.69006413
36translational initiation (GO:0006413)3.67947088
37purine nucleobase biosynthetic process (GO:0009113)3.67251887
38DNA unwinding involved in DNA replication (GO:0006268)3.67237330
39SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.66825440
40kinetochore assembly (GO:0051382)3.66489471
41nucleobase biosynthetic process (GO:0046112)3.65640752
42cotranslational protein targeting to membrane (GO:0006613)3.58769235
43protein targeting to ER (GO:0045047)3.56695863
44deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.56542329
45nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.54286976
46metaphase plate congression (GO:0051310)3.54013783
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.50375197
48ATP synthesis coupled proton transport (GO:0015986)3.50375197
49protein localization to chromosome, centromeric region (GO:0071459)3.48215962
50cellular protein complex disassembly (GO:0043624)3.48092849
51establishment of viral latency (GO:0019043)3.47351661
52protein localization to kinetochore (GO:0034501)3.46376168
53DNA ligation (GO:0006266)3.45956726
54transcription-coupled nucleotide-excision repair (GO:0006283)3.45780595
55rRNA processing (GO:0006364)3.45177307
56ribosome biogenesis (GO:0042254)3.42628535
57termination of RNA polymerase III transcription (GO:0006386)3.42427668
58transcription elongation from RNA polymerase III promoter (GO:0006385)3.42427668
59L-serine metabolic process (GO:0006563)3.40525451
60spliceosomal complex assembly (GO:0000245)3.39353054
61chaperone-mediated protein transport (GO:0072321)3.38273609
62regulation of mitochondrial translation (GO:0070129)3.37892204
63protein localization to endoplasmic reticulum (GO:0070972)3.37461357
64establishment of protein localization to endoplasmic reticulum (GO:0072599)3.36224851
65rRNA metabolic process (GO:0016072)3.35040971
66maturation of 5.8S rRNA (GO:0000460)3.34621900
67regulation of double-strand break repair via homologous recombination (GO:0010569)3.33047114
68viral life cycle (GO:0019058)3.32543566
69formation of translation preinitiation complex (GO:0001731)3.28736103
70rRNA modification (GO:0000154)3.28632597
71cullin deneddylation (GO:0010388)3.24257508
72heterochromatin organization (GO:0070828)3.24158125
73microtubule depolymerization (GO:0007019)3.22731999
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.22688360
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22333267
76somatic hypermutation of immunoglobulin genes (GO:0016446)3.21793131
77somatic diversification of immune receptors via somatic mutation (GO:0002566)3.21793131
78chromatin assembly or disassembly (GO:0006333)3.19780170
79translation (GO:0006412)3.19129625
80establishment of chromosome localization (GO:0051303)3.18408723
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.17641575
82protein complex disassembly (GO:0043241)3.17530809
83attachment of spindle microtubules to kinetochore (GO:0008608)3.13911738
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.12751202
85DNA catabolic process, exonucleolytic (GO:0000738)3.11662887
86regulation of DNA endoreduplication (GO:0032875)3.11350590
87deoxyribonucleotide biosynthetic process (GO:0009263)3.08758647
88mitotic nuclear envelope disassembly (GO:0007077)3.08119437
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07317816
90protein deneddylation (GO:0000338)3.07041001
91pseudouridine synthesis (GO:0001522)3.06787748
92meiotic chromosome segregation (GO:0045132)3.05431076
93regulation of centriole replication (GO:0046599)3.04623246
94translesion synthesis (GO:0019985)3.04488183
95regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.03516814
96protein K6-linked ubiquitination (GO:0085020)3.02353900
97ribosome assembly (GO:0042255)3.02335584
98intra-S DNA damage checkpoint (GO:0031573)3.02218136
99macromolecular complex disassembly (GO:0032984)3.01761043
100replication fork processing (GO:0031297)3.01331397
101cell cycle G1/S phase transition (GO:0044843)3.01305921
102G1/S transition of mitotic cell cycle (GO:0000082)3.01305921
103positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.99898397
104nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99810596
105mitotic sister chromatid segregation (GO:0000070)2.98745613
106chromosome segregation (GO:0007059)2.98127676
1077-methylguanosine mRNA capping (GO:0006370)2.97884661
108mitotic cell cycle (GO:0000278)2.97320791
109spindle checkpoint (GO:0031577)2.97167602
110DNA damage response, detection of DNA damage (GO:0042769)2.97012733
111base-excision repair (GO:0006284)2.96711495
112RNA capping (GO:0036260)2.96689697
1137-methylguanosine RNA capping (GO:0009452)2.96689697
114DNA topological change (GO:0006265)2.96377592
115negative regulation of ligase activity (GO:0051352)2.95944107
116negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.95944107
117termination of RNA polymerase II transcription (GO:0006369)2.95585883
118DNA double-strand break processing (GO:0000729)2.95533520
119mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.95375422
120viral mRNA export from host cell nucleus (GO:0046784)2.95118355
121mismatch repair (GO:0006298)2.94552090
122negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.93715473
123negative regulation of sister chromatid segregation (GO:0033046)2.93715473
124negative regulation of mitotic sister chromatid separation (GO:2000816)2.93715473
125negative regulation of mitotic sister chromatid segregation (GO:0033048)2.93715473
126ATP-dependent chromatin remodeling (GO:0043044)2.92757698
127IMP biosynthetic process (GO:0006188)2.92131780
128nuclear pore organization (GO:0006999)2.91953033
129negative regulation of chromosome segregation (GO:0051985)2.91756792
130cellular component biogenesis (GO:0044085)2.91527862
131postreplication repair (GO:0006301)2.91344342
132telomere maintenance (GO:0000723)2.90531992
133telomere organization (GO:0032200)2.89937210
134maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89386460
135nuclear-transcribed mRNA catabolic process (GO:0000956)2.88490176
136DNA replication (GO:0006260)2.88212159

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.00523357
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.34688060
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.87603920
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.85382192
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.80662408
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.68055053
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.48281952
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.36305992
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.29112534
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.22520324
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.15459727
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.08405514
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.96492114
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94904036
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.88998246
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85488084
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.78091818
18XRN2_22483619_ChIP-Seq_HELA_Human2.47900826
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.42423911
20VDR_23849224_ChIP-Seq_CD4+_Human2.42386488
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41247845
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.40909052
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.34656797
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21805624
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.20800535
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20475308
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19303644
28DCP1A_22483619_ChIP-Seq_HELA_Human2.15460404
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13274339
30FOXP3_21729870_ChIP-Seq_TREG_Human2.07816209
31TTF2_22483619_ChIP-Seq_HELA_Human2.02718581
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02655667
33* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99306282
34* GABP_19822575_ChIP-Seq_HepG2_Human1.96248556
35AR_21909140_ChIP-Seq_LNCAP_Human1.93851505
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91954384
37* E2F1_21310950_ChIP-Seq_MCF-7_Human1.86947940
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.82815854
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82595783
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79364345
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77409663
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72340162
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72217718
44ELK1_19687146_ChIP-ChIP_HELA_Human1.64304828
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.64075814
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63904529
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61875775
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53583757
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48310695
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44517501
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41981342
52CIITA_25753668_ChIP-Seq_RAJI_Human1.37598196
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36597984
54KDM5A_27292631_Chip-Seq_BREAST_Human1.36228734
55* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35961226
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35352670
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30112127
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26749313
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26653717
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25873228
61MYC_18940864_ChIP-ChIP_HL60_Human1.21222280
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.20969953
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17318168
64* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14847762
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.14298285
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14083406
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13336583
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12110631
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11257045
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11242034
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10257920
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10128350
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06745104
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.02291823
75* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01485153
76ELK1_22589737_ChIP-Seq_MCF10A_Human1.00983188
77KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97998322
78NANOG_16153702_ChIP-ChIP_HESCs_Human0.96852081
79EWS_26573619_Chip-Seq_HEK293_Human0.95425039
80SOX2_16153702_ChIP-ChIP_HESCs_Human0.91472487
81POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91367773
82STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91000234
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88172853
84SOX17_20123909_ChIP-Seq_XEN_Mouse0.88104004
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88098849
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87749160
87* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87686895
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86525781
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84218035
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84074209
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83514296
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80504334
93TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80275511
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78702388
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77218826
96* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76092646
97MYC_22102868_ChIP-Seq_BL_Human0.75132197
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73428383
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72934861
100FOXP1_21924763_ChIP-Seq_HESCs_Human0.72004843
101NANOG_21062744_ChIP-ChIP_HESCs_Human0.71573583
102FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71006624
103* SPI1_23547873_ChIP-Seq_NB4_Human0.70507366
104IRF1_19129219_ChIP-ChIP_H3396_Human0.70299595
105TFEB_21752829_ChIP-Seq_HELA_Human0.70161130
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.70030101
107NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.69801175
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.68825003
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.68003894
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.67644861
111SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.67612086
112* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.67584846
113CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.67069310
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.66718734
115SOX2_18692474_ChIP-Seq_MEFs_Mouse0.65566558
116ESR1_15608294_ChIP-ChIP_MCF-7_Human0.64206979

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.78468308
2MP0010094_abnormal_chromosome_stability4.77050922
3MP0003111_abnormal_nucleus_morphology4.50346464
4MP0004957_abnormal_blastocyst_morpholog4.26993942
5MP0008057_abnormal_DNA_replication4.13532585
6MP0003077_abnormal_cell_cycle4.01788547
7MP0008058_abnormal_DNA_repair3.96471485
8MP0008877_abnormal_DNA_methylation3.12996381
9MP0008007_abnormal_cellular_replicative3.03373342
10MP0008932_abnormal_embryonic_tissue3.02191824
11MP0009379_abnormal_foot_pigmentation2.88225183
12MP0006292_abnormal_olfactory_placode2.31578309
13MP0005410_abnormal_fertilization2.28650884
14MP0010030_abnormal_orbit_morphology2.17495785
15MP0003786_premature_aging2.09173352
16MP0003806_abnormal_nucleotide_metabolis2.00997665
17* MP0002210_abnormal_sex_determination2.00829352
18* MP0001929_abnormal_gametogenesis1.98285547
19MP0003123_paternal_imprinting1.97640116
20MP0002396_abnormal_hematopoietic_system1.96107126
21MP0009697_abnormal_copulation1.95473143
22MP0001730_embryonic_growth_arrest1.95397747
23MP0000350_abnormal_cell_proliferation1.94154461
24MP0003718_maternal_effect1.89524765
25MP0003315_abnormal_perineum_morphology1.75667928
26MP0003136_yellow_coat_color1.74422791
27* MP0001145_abnormal_male_reproductive1.64325700
28MP0003698_abnormal_male_reproductive1.57709096
29MP0005499_abnormal_olfactory_system1.51847690
30MP0005394_taste/olfaction_phenotype1.51847690
31MP0000490_abnormal_crypts_of1.51360015
32MP0002160_abnormal_reproductive_system1.50098271
33MP0001672_abnormal_embryogenesis/_devel1.42896097
34MP0005380_embryogenesis_phenotype1.42896097
35* MP0000653_abnormal_sex_gland1.42546691
36MP0001697_abnormal_embryo_size1.41214964
37MP0000313_abnormal_cell_death1.40633676
38MP0005171_absent_coat_pigmentation1.36219072
39MP0002085_abnormal_embryonic_tissue1.34718413
40MP0002080_prenatal_lethality1.33231358
41MP0000566_synostosis1.32715982
42MP0002102_abnormal_ear_morphology1.27770196
43MP0004133_heterotaxia1.23211645
44MP0003984_embryonic_growth_retardation1.22720259
45MP0002019_abnormal_tumor_incidence1.22466354
46MP0002697_abnormal_eye_size1.22414744
47MP0002163_abnormal_gland_morphology1.18173921
48MP0002088_abnormal_embryonic_growth/wei1.17114465
49MP0002653_abnormal_ependyma_morphology1.16521086
50MP0000372_irregular_coat_pigmentation1.16101893
51MP0001293_anophthalmia1.15971083
52MP0001188_hyperpigmentation1.12793798
53MP0006072_abnormal_retinal_apoptosis1.12225999
54MP0009333_abnormal_splenocyte_physiolog1.11099860
55MP0003763_abnormal_thymus_physiology1.07031634
56MP0002233_abnormal_nose_morphology1.06731938
57MP0005389_reproductive_system_phenotype1.04638477
58MP0002084_abnormal_developmental_patter1.04345582
59MP0000049_abnormal_middle_ear1.03763514
60MP0003121_genomic_imprinting1.02207528
61MP0001346_abnormal_lacrimal_gland1.01793679
62MP0002132_abnormal_respiratory_system0.98356113
63MP0004808_abnormal_hematopoietic_stem0.97326867
64MP0005174_abnormal_tail_pigmentation0.95985049
65* MP0002161_abnormal_fertility/fecundity0.95861701
66MP0003937_abnormal_limbs/digits/tail_de0.95333266
67MP0006036_abnormal_mitochondrial_physio0.95205890
68MP0002095_abnormal_skin_pigmentation0.94582359
69MP0010307_abnormal_tumor_latency0.93190312
70MP0003567_abnormal_fetal_cardiomyocyte0.92704739
71MP0005075_abnormal_melanosome_morpholog0.91837416
72MP0001529_abnormal_vocalization0.89421407
73MP0000703_abnormal_thymus_morphology0.88574261
74MP0003755_abnormal_palate_morphology0.88488070
75MP0003119_abnormal_digestive_system0.88210416
76* MP0001119_abnormal_female_reproductive0.85887870
77MP0000358_abnormal_cell_content/0.85150241
78MP0002736_abnormal_nociception_after0.84909543
79MP0002638_abnormal_pupillary_reflex0.84540106
80MP0003122_maternal_imprinting0.82541837
81MP0000647_abnormal_sebaceous_gland0.80341953
82MP0002086_abnormal_extraembryonic_tissu0.78827423
83MP0001286_abnormal_eye_development0.78440520
84MP0003938_abnormal_ear_development0.77766860
85MP0003221_abnormal_cardiomyocyte_apopto0.76842244
86MP0005408_hypopigmentation0.76567779
87MP0005409_darkened_coat_color0.76130335
88MP0000858_altered_metastatic_potential0.76076055
89MP0002234_abnormal_pharynx_morphology0.76062455
90MP0000015_abnormal_ear_pigmentation0.75802916
91MP0008789_abnormal_olfactory_epithelium0.75742186
92MP0000631_abnormal_neuroendocrine_gland0.75526361
93MP0001545_abnormal_hematopoietic_system0.74773594
94MP0005397_hematopoietic_system_phenotyp0.74773594
95MP0002398_abnormal_bone_marrow0.74194349
96MP0003186_abnormal_redox_activity0.74088109
97MP0004197_abnormal_fetal_growth/weight/0.73682133
98MP0003942_abnormal_urinary_system0.71498899
99MP0001919_abnormal_reproductive_system0.70970899
100MP0003941_abnormal_skin_development0.70093680
101MP0006035_abnormal_mitochondrial_morpho0.70030758
102MP0002177_abnormal_outer_ear0.67637964
103MP0001299_abnormal_eye_distance/0.67519027
104MP0005187_abnormal_penis_morphology0.66882791
105MP0002722_abnormal_immune_system0.66564809
106MP0000689_abnormal_spleen_morphology0.66301524
107MP0001485_abnormal_pinna_reflex0.66292391
108MP0000428_abnormal_craniofacial_morphol0.64153580
109MP0009672_abnormal_birth_weight0.63741032
110MP0004147_increased_porphyrin_level0.63662154
111MP0003385_abnormal_body_wall0.63426948
112MP0003890_abnormal_embryonic-extraembry0.63425227
113MP0002249_abnormal_larynx_morphology0.63008533
114MP0002092_abnormal_eye_morphology0.62671157
115MP0000750_abnormal_muscle_regeneration0.62463695
116MP0003878_abnormal_ear_physiology0.62115235
117MP0005377_hearing/vestibular/ear_phenot0.62115235
118MP0009053_abnormal_anal_canal0.61581880
119MP0002429_abnormal_blood_cell0.60339815
120MP0002751_abnormal_autonomic_nervous0.60311074
121MP0002938_white_spotting0.59460317
122MP0008995_early_reproductive_senescence0.58854628
123MP0003861_abnormal_nervous_system0.58653820
124MP0003011_delayed_dark_adaptation0.55624657
125MP0005076_abnormal_cell_differentiation0.55295325
126MP0002111_abnormal_tail_morphology0.55101153
127MP0010352_gastrointestinal_tract_polyps0.54930109
128MP0005391_vision/eye_phenotype0.54246770
129MP0003646_muscle_fatigue0.53468982

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.98668563
2Reticulocytopenia (HP:0001896)4.77403540
3Abnormality of cells of the erythroid lineage (HP:0012130)4.33082727
4Abnormal number of erythroid precursors (HP:0012131)4.26405414
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.91365738
6Breast hypoplasia (HP:0003187)3.85041551
7Chromsome breakage (HP:0040012)3.64424124
8Oral leukoplakia (HP:0002745)3.52708950
9Patellar aplasia (HP:0006443)3.47760924
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.42514803
11Meckel diverticulum (HP:0002245)3.37956508
12Acute encephalopathy (HP:0006846)3.37280517
13Aplastic anemia (HP:0001915)3.33402027
14Aplasia/Hypoplasia of the patella (HP:0006498)3.32501556
15Macrocytic anemia (HP:0001972)3.22412186
16Abnormality of the ileum (HP:0001549)3.19382587
17Aplasia/Hypoplasia of the sacrum (HP:0008517)3.17723766
18Abnormality of the preputium (HP:0100587)3.15500543
19Abnormality of the heme biosynthetic pathway (HP:0010472)3.11623900
20Pallor (HP:0000980)3.02053368
2111 pairs of ribs (HP:0000878)2.99722429
22Carpal bone hypoplasia (HP:0001498)2.98262905
23Abnormality of chromosome stability (HP:0003220)2.96492343
24Absent thumb (HP:0009777)2.90584503
25Dynein arm defect of respiratory motile cilia (HP:0012255)2.89786926
26Absent/shortened dynein arms (HP:0200106)2.89786926
27Abnormal respiratory epithelium morphology (HP:0012253)2.87947573
28Abnormal respiratory motile cilium morphology (HP:0005938)2.87947573
29Impulsivity (HP:0100710)2.86172592
30Abnormality of the labia minora (HP:0012880)2.84971927
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.83797009
32Abnormality of the carotid arteries (HP:0005344)2.82053015
33Degeneration of anterior horn cells (HP:0002398)2.71330439
34Abnormality of the anterior horn cell (HP:0006802)2.71330439
35Progressive macrocephaly (HP:0004481)2.71069820
36Colon cancer (HP:0003003)2.68597892
37Rough bone trabeculation (HP:0100670)2.67454767
38Abnormal respiratory motile cilium physiology (HP:0012261)2.65083162
39Hypoplasia of the capital femoral epiphysis (HP:0003090)2.59948607
40Cerebral edema (HP:0002181)2.53721308
41Cleft eyelid (HP:0000625)2.52057580
42Supernumerary spleens (HP:0009799)2.50620947
43Triphalangeal thumb (HP:0001199)2.50483587
44Renal Fanconi syndrome (HP:0001994)2.50148592
45Cerebral hypomyelination (HP:0006808)2.49125577
46Duodenal stenosis (HP:0100867)2.43130320
47Small intestinal stenosis (HP:0012848)2.43130320
48Abnormality of cochlea (HP:0000375)2.42786132
49Horseshoe kidney (HP:0000085)2.42669027
50Microretrognathia (HP:0000308)2.42186213
51Selective tooth agenesis (HP:0001592)2.41521685
52Bone marrow hypocellularity (HP:0005528)2.39198127
53Hypoplastic pelvis (HP:0008839)2.35577925
54Medulloblastoma (HP:0002885)2.32952225
55Absent radius (HP:0003974)2.31823253
56Rhinitis (HP:0012384)2.30792050
57Abnormal lung lobation (HP:0002101)2.30278100
58Abnormal ciliary motility (HP:0012262)2.26802793
59Hepatocellular necrosis (HP:0001404)2.25558997
60Sloping forehead (HP:0000340)2.25540710
61Acute necrotizing encephalopathy (HP:0006965)2.23821747
62Myelodysplasia (HP:0002863)2.23029119
63Pancytopenia (HP:0001876)2.21452749
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20323581
65Duplication of thumb phalanx (HP:0009942)2.19847556
66Neoplasm of the pancreas (HP:0002894)2.18833679
67Mitochondrial inheritance (HP:0001427)2.18213066
68Facial cleft (HP:0002006)2.17344428
69Abnormal spermatogenesis (HP:0008669)2.15862909
70Aplasia involving forearm bones (HP:0009822)2.15814621
71Absent forearm bone (HP:0003953)2.15814621
72Chronic bronchitis (HP:0004469)2.13957431
73Increased hepatocellular lipid droplets (HP:0006565)2.12412917
74Premature graying of hair (HP:0002216)2.09808801
75Increased serum pyruvate (HP:0003542)2.08217704
76Pancreatic cysts (HP:0001737)2.07803276
77Decreased activity of mitochondrial respiratory chain (HP:0008972)2.06234500
78Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.06234500
79Hyperglycinemia (HP:0002154)2.06214605
80Hypoplasia of the radius (HP:0002984)2.05437977
81Increased serum lactate (HP:0002151)2.05354444
82Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.04672872
83Increased nuchal translucency (HP:0010880)2.03936621
84Optic nerve coloboma (HP:0000588)2.02118838
85Duplicated collecting system (HP:0000081)2.01662173
86Nephroblastoma (Wilms tumor) (HP:0002667)2.01577991
87Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01547979
88Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.01169581
89Absent epiphyses (HP:0010577)2.01169581
90Increased intramyocellular lipid droplets (HP:0012240)2.00771195
91Increased CSF lactate (HP:0002490)2.00291115
92Ectopic kidney (HP:0000086)1.99671713
93Morphological abnormality of the inner ear (HP:0011390)1.99037196
94Abnormal number of incisors (HP:0011064)1.98680426
95Abnormality of glycolysis (HP:0004366)1.98659501
96Cortical dysplasia (HP:0002539)1.98315885
97Abnormal mitochondria in muscle tissue (HP:0008316)1.97182073
98Hypoplasia of the pons (HP:0012110)1.96925733
99Oligodactyly (hands) (HP:0001180)1.96364989
100Abnormality of the duodenum (HP:0002246)1.96180914
101Pancreatic fibrosis (HP:0100732)1.95903919
102Atresia of the external auditory canal (HP:0000413)1.95743982
103Cellular immunodeficiency (HP:0005374)1.95709533
104Oligodactyly (HP:0012165)1.94390983
105Tracheoesophageal fistula (HP:0002575)1.92808617
106Rib fusion (HP:0000902)1.89481946
107Absent septum pellucidum (HP:0001331)1.88937464
108Abnormality of DNA repair (HP:0003254)1.88134785
109Septo-optic dysplasia (HP:0100842)1.87709387
110Volvulus (HP:0002580)1.87452009
111Squamous cell carcinoma (HP:0002860)1.86696291
112Lactic acidosis (HP:0003128)1.86395564
113Respiratory difficulties (HP:0002880)1.85708235
114Microvesicular hepatic steatosis (HP:0001414)1.85396937
115Clubbing of toes (HP:0100760)1.84884916
116Type I transferrin isoform profile (HP:0003642)1.84606917
117Exercise intolerance (HP:0003546)1.83814682
118Embryonal renal neoplasm (HP:0011794)1.83634086
119Aplasia/Hypoplasia of the sternum (HP:0006714)1.83569201
120* Secondary amenorrhea (HP:0000869)1.83043036
121Exertional dyspnea (HP:0002875)1.82701813
122Hepatic necrosis (HP:0002605)1.80790898
123Short thumb (HP:0009778)1.80067202
124Lipid accumulation in hepatocytes (HP:0006561)1.79771163
125Abnormal trabecular bone morphology (HP:0100671)1.79357435
126Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79252142
127Abnormality of alanine metabolism (HP:0010916)1.79252142
128Hyperalaninemia (HP:0003348)1.79252142
129Ependymoma (HP:0002888)1.77974383
130Leukodystrophy (HP:0002415)1.77959124
131Trismus (HP:0000211)1.77850400
132Abdominal situs inversus (HP:0003363)1.77390973
133Abnormality of abdominal situs (HP:0011620)1.77390973
134Abnormality of the pons (HP:0007361)1.76938950
135Abnormality of the renal collecting system (HP:0004742)1.75658942
136Testicular atrophy (HP:0000029)1.74993130
137Methylmalonic acidemia (HP:0002912)1.74263259
138Preaxial hand polydactyly (HP:0001177)1.69878810

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.72755948
2WEE14.39983175
3CDC73.91236622
4SRPK13.59898097
5STK163.24521350
6EIF2AK13.18335721
7VRK22.99071274
8TLK12.79326163
9TTK2.52022951
10NME22.42297073
11VRK12.40646826
12PLK42.31644875
13BRSK22.30987681
14NEK22.30688881
15DYRK32.14259262
16PLK12.01421646
17EIF2AK31.93497194
18ACVR1B1.91753656
19TESK21.84493699
20TSSK61.84188963
21MKNK21.82630239
22MKNK11.81070884
23TRIM281.80828833
24CHEK21.76667823
25AURKB1.73281330
26PLK31.69137215
27CCNB11.63194043
28ATR1.60837527
29RPS6KA41.49645926
30BRSK11.45816557
31CDK71.43380016
32AURKA1.35767877
33NEK11.32586909
34PDK41.30907779
35PDK31.30907779
36CLK11.15521185
37PASK1.09839484
38CHEK11.08803516
39CDK81.07565207
40TESK10.99863374
41NME10.97709167
42PBK0.97343697
43BCR0.96799594
44CDK40.91244192
45BCKDK0.91061105
46PLK20.87311383
47CSNK1G30.85041043
48TAF10.84645933
49MST40.84552416
50ATM0.83998851
51PIM20.83868793
52EIF2AK20.83324403
53ZAK0.82841576
54DYRK20.81620631
55BRAF0.80950548
56CSNK2A10.80636227
57TNIK0.80562781
58PNCK0.80015885
59IRAK40.75570488
60YES10.73317353
61CSNK1A1L0.73055693
62STK40.71796199
63MAP3K80.71344365
64CDK20.71280808
65CSNK2A20.70419640
66CSNK1G10.70268247
67NUAK10.70151350
68CSNK1G20.68078662
69STK390.66781097
70WNK40.66380581
71KDR0.65117911
72PIM10.64992291
73RPS6KB20.62148870
74MAP2K70.62054496
75RPS6KA50.60553444
76PAK10.58342198
77LIMK10.58156962
78CDK10.58038404
79MAP3K60.57749901
80MAP4K20.55603342
81WNK30.54693253
82PDK20.54461932
83TGFBR10.54076987
84CDK30.53584990
85EPHB20.52626689
86MAP3K120.52528222
87IRAK30.52139627
88EPHA20.51430027
89ERBB30.49881174
90DAPK10.48534078
91PAK40.47775923
92STK100.46437800
93ERBB40.44886121
94ABL20.43654329
95MINK10.43218010
96PRKCI0.42632464
97IRAK10.41397825
98ALK0.37521910
99BMPR1B0.37363879
100OXSR10.37050718
101MUSK0.34538666
102TEC0.33128816
103LRRK20.32582841
104AKT30.32529103
105CASK0.31870518
106STK30.31019878
107CDK190.30573543
108PRKDC0.29716935
109MAP3K100.28468979
110STK38L0.27567055
111MAPKAPK50.25913810
112MAP3K40.25019489
113KIT0.24949832
114ARAF0.24291829
115PRKCG0.23728778
116CSNK1E0.22873408
117MELK0.21506739
118PRKD20.21288974
119CDK60.20403797
120CDK11A0.20162144
121FLT30.19523277
122SCYL20.17303417
123CDK180.17158454
124LYN0.16650847
125BLK0.16601070
126MAPK150.16512548
127CDK150.16179377
128MARK30.13372856
129AKT20.13329477
130CDK140.12707891

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.31348484
2Ribosome_Homo sapiens_hsa030104.28224063
3Mismatch repair_Homo sapiens_hsa034304.16717505
4RNA polymerase_Homo sapiens_hsa030203.68510754
5Proteasome_Homo sapiens_hsa030503.51534517
6Spliceosome_Homo sapiens_hsa030403.48439417
7Homologous recombination_Homo sapiens_hsa034403.44337518
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.25749829
9Nucleotide excision repair_Homo sapiens_hsa034202.96580390
10Base excision repair_Homo sapiens_hsa034102.94435327
11RNA transport_Homo sapiens_hsa030132.86987212
12Pyrimidine metabolism_Homo sapiens_hsa002402.81087209
13Cell cycle_Homo sapiens_hsa041102.65038511
14Fanconi anemia pathway_Homo sapiens_hsa034602.63941187
15Basal transcription factors_Homo sapiens_hsa030222.25283640
16One carbon pool by folate_Homo sapiens_hsa006701.99509803
17Non-homologous end-joining_Homo sapiens_hsa034501.93227026
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91140767
19RNA degradation_Homo sapiens_hsa030181.90722607
20Purine metabolism_Homo sapiens_hsa002301.70007940
21mRNA surveillance pathway_Homo sapiens_hsa030151.59319384
22Huntingtons disease_Homo sapiens_hsa050161.56077452
23Parkinsons disease_Homo sapiens_hsa050121.39103797
24Oxidative phosphorylation_Homo sapiens_hsa001901.36880860
25Protein export_Homo sapiens_hsa030601.36743784
26p53 signaling pathway_Homo sapiens_hsa041151.34319149
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22743118
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15979220
29Systemic lupus erythematosus_Homo sapiens_hsa053221.15506336
30Epstein-Barr virus infection_Homo sapiens_hsa051691.12067478
31Oocyte meiosis_Homo sapiens_hsa041141.09894229
32Vitamin B6 metabolism_Homo sapiens_hsa007501.04632420
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03926911
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01625717
35Propanoate metabolism_Homo sapiens_hsa006401.00546293
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92228339
37Pentose phosphate pathway_Homo sapiens_hsa000300.85607733
38Antigen processing and presentation_Homo sapiens_hsa046120.84079991
39Fatty acid elongation_Homo sapiens_hsa000620.83914368
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82765200
41Steroid biosynthesis_Homo sapiens_hsa001000.82400259
42Alzheimers disease_Homo sapiens_hsa050100.77907104
43Herpes simplex infection_Homo sapiens_hsa051680.75674726
44Folate biosynthesis_Homo sapiens_hsa007900.70595445
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68525663
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67673842
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67420540
48Viral carcinogenesis_Homo sapiens_hsa052030.65152836
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62811506
50Sulfur relay system_Homo sapiens_hsa041220.61080347
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.58395244
52HTLV-I infection_Homo sapiens_hsa051660.56035462
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55473899
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49989258
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.49274112
56Biosynthesis of amino acids_Homo sapiens_hsa012300.48688521
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46535158
58Alcoholism_Homo sapiens_hsa050340.45190585
59Glutathione metabolism_Homo sapiens_hsa004800.44320012
60Primary immunodeficiency_Homo sapiens_hsa053400.42465862
61Selenocompound metabolism_Homo sapiens_hsa004500.40955130
62Metabolic pathways_Homo sapiens_hsa011000.39016983
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36169659
64Thyroid cancer_Homo sapiens_hsa052160.35796468
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34169293
66Basal cell carcinoma_Homo sapiens_hsa052170.32578794
67Carbon metabolism_Homo sapiens_hsa012000.30792173
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29700850
69Cardiac muscle contraction_Homo sapiens_hsa042600.29607609
70N-Glycan biosynthesis_Homo sapiens_hsa005100.29458203
71MicroRNAs in cancer_Homo sapiens_hsa052060.28119014
72Hedgehog signaling pathway_Homo sapiens_hsa043400.28008881
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27420124
74Arachidonic acid metabolism_Homo sapiens_hsa005900.26322868
75Fatty acid metabolism_Homo sapiens_hsa012120.25683656
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25660722
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23951080
78Arginine and proline metabolism_Homo sapiens_hsa003300.23725256
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23587636
80beta-Alanine metabolism_Homo sapiens_hsa004100.23238953
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23143765
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.22373870
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22005342
84Small cell lung cancer_Homo sapiens_hsa052220.21789269
85Wnt signaling pathway_Homo sapiens_hsa043100.21659722
86Butanoate metabolism_Homo sapiens_hsa006500.21461854
87Legionellosis_Homo sapiens_hsa051340.20740369
88Lysine degradation_Homo sapiens_hsa003100.18714721
89Peroxisome_Homo sapiens_hsa041460.18375285
90Measles_Homo sapiens_hsa051620.17305968
91Hepatitis B_Homo sapiens_hsa051610.15855836
92TGF-beta signaling pathway_Homo sapiens_hsa043500.15644383
93Hippo signaling pathway_Homo sapiens_hsa043900.15626470
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15486643
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14714535
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14068491
97Pyruvate metabolism_Homo sapiens_hsa006200.12872609
98Sulfur metabolism_Homo sapiens_hsa009200.12757287
99Renin-angiotensin system_Homo sapiens_hsa046140.12452044
100Fructose and mannose metabolism_Homo sapiens_hsa000510.10858713
101Colorectal cancer_Homo sapiens_hsa052100.10822124
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.10814078
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10504675
104Linoleic acid metabolism_Homo sapiens_hsa005910.10481755
105Shigellosis_Homo sapiens_hsa051310.10454713
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.10094091
107Apoptosis_Homo sapiens_hsa042100.09758433
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09402819
109Pathways in cancer_Homo sapiens_hsa052000.08716689
110Fatty acid degradation_Homo sapiens_hsa000710.08094478
111Phototransduction_Homo sapiens_hsa047440.08073446
112Galactose metabolism_Homo sapiens_hsa000520.06780818
113Asthma_Homo sapiens_hsa053100.06253373
114Nicotine addiction_Homo sapiens_hsa050330.06141929
115Allograft rejection_Homo sapiens_hsa053300.05307979
116Notch signaling pathway_Homo sapiens_hsa043300.05024237
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.04875999
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.04791100
119Regulation of autophagy_Homo sapiens_hsa041400.04568424
120Vitamin digestion and absorption_Homo sapiens_hsa049770.04531173
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.04466674
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.03661966
123Bladder cancer_Homo sapiens_hsa052190.03355683
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.03091429
125Hematopoietic cell lineage_Homo sapiens_hsa046400.03088663
126Tyrosine metabolism_Homo sapiens_hsa003500.02913942
127Melanoma_Homo sapiens_hsa052180.02888855
128Autoimmune thyroid disease_Homo sapiens_hsa053200.02199335
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.02001857

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