PSMC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.36371784
2* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.96647660
3purine nucleobase biosynthetic process (GO:0009113)4.69662882
4* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.68188317
5nucleobase biosynthetic process (GO:0046112)4.63671461
6* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.60945353
7formation of translation preinitiation complex (GO:0001731)4.57509839
8* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.56862177
9* negative regulation of ligase activity (GO:0051352)4.52223881
10* negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.52223881
11DNA deamination (GO:0045006)4.43129234
12cullin deneddylation (GO:0010388)4.42479726
13* regulation of cellular amino acid metabolic process (GO:0006521)4.39709915
14DNA strand elongation involved in DNA replication (GO:0006271)4.38016892
15maturation of SSU-rRNA (GO:0030490)4.34832017
16* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.26713201
17protein deneddylation (GO:0000338)4.25508611
18ribosomal small subunit assembly (GO:0000028)4.25058621
19telomere maintenance via semi-conservative replication (GO:0032201)4.22551651
20* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.19016480
21* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.19016480
22* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.17923652
23* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.17923652
24* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.17923652
25DNA strand elongation (GO:0022616)4.17812638
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.15776413
27L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.12129027
28* signal transduction involved in DNA integrity checkpoint (GO:0072401)4.10229192
29* signal transduction involved in DNA damage checkpoint (GO:0072422)4.10229192
30* positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.06501835
31* signal transduction involved in cell cycle checkpoint (GO:0072395)4.05850621
32DNA replication initiation (GO:0006270)4.04443438
33transcription elongation from RNA polymerase III promoter (GO:0006385)4.01216202
34termination of RNA polymerase III transcription (GO:0006386)4.01216202
357-methylguanosine mRNA capping (GO:0006370)3.96311316
36* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.93466015
37spliceosomal snRNP assembly (GO:0000387)3.92447198
38RNA capping (GO:0036260)3.87110323
397-methylguanosine RNA capping (GO:0009452)3.87110323
40ribosome biogenesis (GO:0042254)3.86885477
41* positive regulation of ligase activity (GO:0051351)3.85864672
42* negative regulation of protein ubiquitination (GO:0031397)3.84602102
43rRNA modification (GO:0000154)3.80858718
44ribosomal large subunit biogenesis (GO:0042273)3.80610325
45ATP synthesis coupled proton transport (GO:0015986)3.76730280
46energy coupled proton transport, down electrochemical gradient (GO:0015985)3.76730280
47establishment of viral latency (GO:0019043)3.76676863
48ribonucleoprotein complex biogenesis (GO:0022613)3.75767894
49ribosome assembly (GO:0042255)3.75511526
50telomere maintenance via recombination (GO:0000722)3.72105071
51chaperone-mediated protein transport (GO:0072321)3.68461934
52regulation of translational termination (GO:0006449)3.67765418
53DNA replication checkpoint (GO:0000076)3.67396097
54protein maturation by protein folding (GO:0022417)3.65993870
55* negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.64907162
56* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.64581522
57ribosomal small subunit biogenesis (GO:0042274)3.63064474
58* regulation of ubiquitin-protein transferase activity (GO:0051438)3.61382910
59amino acid salvage (GO:0043102)3.60440333
60L-methionine salvage (GO:0071267)3.60440333
61L-methionine biosynthetic process (GO:0071265)3.60440333
62deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.55938787
63transcription-coupled nucleotide-excision repair (GO:0006283)3.55405283
64CENP-A containing nucleosome assembly (GO:0034080)3.52631328
65* cell cycle G1/S phase transition (GO:0044843)3.52571317
66* G1/S transition of mitotic cell cycle (GO:0000082)3.52571317
67pseudouridine synthesis (GO:0001522)3.50776653
68rRNA processing (GO:0006364)3.50656042
69viral mRNA export from host cell nucleus (GO:0046784)3.49954660
70* regulation of ligase activity (GO:0051340)3.46038978
71establishment of protein localization to mitochondrial membrane (GO:0090151)3.45021846
72IMP biosynthetic process (GO:0006188)3.43842187
73* signal transduction in response to DNA damage (GO:0042770)3.43518488
74mitotic recombination (GO:0006312)3.42843265
75* positive regulation of cell cycle arrest (GO:0071158)3.39214487
76viral transcription (GO:0019083)3.39072553
77* DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.38305166
78translational termination (GO:0006415)3.37645947
79* regulation of cell cycle arrest (GO:0071156)3.37594614
80spliceosomal complex assembly (GO:0000245)3.35546582
81chromatin remodeling at centromere (GO:0031055)3.35354781
82rRNA metabolic process (GO:0016072)3.34690000
83telomere maintenance via telomere lengthening (GO:0010833)3.34206672
84translation (GO:0006412)3.34088343
85establishment of integrated proviral latency (GO:0075713)3.33228047
86cellular component biogenesis (GO:0044085)3.32406384
87translational initiation (GO:0006413)3.31017863
88* negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)3.30770960
89* negative regulation of cell cycle G1/S phase transition (GO:1902807)3.30770960
90regulation of mitochondrial translation (GO:0070129)3.30674967
91tRNA aminoacylation for protein translation (GO:0006418)3.30547206
92nucleotide-excision repair, DNA gap filling (GO:0006297)3.28502036
93protein localization to mitochondrion (GO:0070585)3.28483236
94DNA unwinding involved in DNA replication (GO:0006268)3.26517957
95mitotic metaphase plate congression (GO:0007080)3.26219210
96transcription elongation from RNA polymerase I promoter (GO:0006362)3.25061774
97tRNA aminoacylation (GO:0043039)3.24894094
98amino acid activation (GO:0043038)3.24894094
99RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.23719244
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.23719244
101translational elongation (GO:0006414)3.21360464
102mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.21004926
103DNA damage response, detection of DNA damage (GO:0042769)3.20869548
104* regulation of cellular amine metabolic process (GO:0033238)3.20289030
105protein neddylation (GO:0045116)3.19898178
106transcription from RNA polymerase I promoter (GO:0006360)3.18576480
107termination of RNA polymerase I transcription (GO:0006363)3.16380930
108peptidyl-histidine modification (GO:0018202)3.15588986
109mitotic sister chromatid segregation (GO:0000070)3.14040686
110establishment of protein localization to mitochondrion (GO:0072655)3.13507999
111guanosine-containing compound biosynthetic process (GO:1901070)3.12656430
112DNA replication-dependent nucleosome organization (GO:0034723)3.10728943
113DNA replication-dependent nucleosome assembly (GO:0006335)3.10728943
114maturation of 5.8S rRNA (GO:0000460)3.09278133
115deoxyribonucleotide biosynthetic process (GO:0009263)3.07432507
116SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.06396391
117metaphase plate congression (GO:0051310)3.06021618
118nucleobase-containing small molecule interconversion (GO:0015949)3.05711453
119* positive regulation of protein ubiquitination (GO:0031398)3.05146900
120de novo protein folding (GO:0006458)3.04446038
121protein targeting to mitochondrion (GO:0006626)3.04113466
122respiratory electron transport chain (GO:0022904)3.03798564
123oxidative phosphorylation (GO:0006119)3.03704142
124* antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.02703963
125inner mitochondrial membrane organization (GO:0007007)2.96758994
126de novo posttranslational protein folding (GO:0051084)2.95740501
127electron transport chain (GO:0022900)2.94672737
128peptidyl-arginine omega-N-methylation (GO:0035247)2.89918851
129* positive regulation of protein modification by small protein conjugation or removal (GO:1903322)2.89753574
130pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.88883043
131regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88021240
132mitochondrial respiratory chain complex assembly (GO:0033108)2.83151256

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.07351667
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.44800160
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.41498155
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.02519232
5* EST1_17652178_ChIP-ChIP_JURKAT_Human3.96671349
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.90023238
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.89268371
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.59930973
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.53092364
10* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.30697690
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.23453199
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.20228117
13MYC_19079543_ChIP-ChIP_MESCs_Mouse3.02375170
14MYC_19030024_ChIP-ChIP_MESCs_Mouse3.01346086
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.93596109
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91613704
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.80936272
18* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.57778710
19* VDR_23849224_ChIP-Seq_CD4+_Human2.53885413
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.48525043
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.47149322
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46612031
23* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.46169822
24XRN2_22483619_ChIP-Seq_HELA_Human2.45200351
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.43426633
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.43090513
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42990489
28DCP1A_22483619_ChIP-Seq_HELA_Human2.35132876
29FOXP3_21729870_ChIP-Seq_TREG_Human2.19829318
30YY1_21170310_ChIP-Seq_MESCs_Mouse2.18573117
31GABP_19822575_ChIP-Seq_HepG2_Human2.17357746
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.14746202
33FOXM1_23109430_ChIP-Seq_U2OS_Human2.11142539
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02853256
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.95830316
36TTF2_22483619_ChIP-Seq_HELA_Human1.95183034
37* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.92599140
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.90780614
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86267117
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85013910
41ELK1_19687146_ChIP-ChIP_HELA_Human1.83451741
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79693127
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78755877
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76011335
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75426880
46AR_21909140_ChIP-Seq_LNCAP_Human1.69135373
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59059869
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58498290
49CIITA_25753668_ChIP-Seq_RAJI_Human1.50477580
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48317708
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46449135
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44301365
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43982191
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.40677087
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39648925
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39334444
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39257234
58KDM5A_27292631_Chip-Seq_BREAST_Human1.33984214
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31020952
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29432621
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.24746984
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23430997
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23200548
64* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19314088
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18248253
66KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16990696
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15009091
68* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14589388
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11785470
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11351927
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11109923
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07961006
73TFEB_21752829_ChIP-Seq_HELA_Human1.07629514
74MYC_18940864_ChIP-ChIP_HL60_Human1.06832494
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04890556
76* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04460404
77* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04166851
78* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03732241
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03346784
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99460355
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99332785
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98854921
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98028188
84KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97709336
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97019789
86OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96415299
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95558514
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95542266
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94144876
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93663444
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93208632
92TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92152699
93SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91798184
94* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90698287
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90664759
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90603651
97* SOX17_20123909_ChIP-Seq_XEN_Mouse0.89949724
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89530588
99ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88826765
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88656329
101NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87594514
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86622579
103SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85381533
104ZNF263_19887448_ChIP-Seq_K562_Human0.85166998
105CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84954241
106* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83440587
107NOTCH1_21737748_ChIP-Seq_TLL_Human0.83016791
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80661928
109SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79274992
110* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77169574
111NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.76737665
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75953918
113NANOG_16153702_ChIP-ChIP_HESCs_Human0.75112993
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.74887659
115TCF3_18692474_ChIP-Seq_MEFs_Mouse0.74767541
116FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73688363

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.94020280
2MP0004957_abnormal_blastocyst_morpholog4.91297863
3MP0010094_abnormal_chromosome_stability4.37837011
4MP0003111_abnormal_nucleus_morphology4.37734582
5MP0003077_abnormal_cell_cycle4.01145308
6MP0008058_abnormal_DNA_repair3.79117229
7MP0003806_abnormal_nucleotide_metabolis3.54515764
8MP0008057_abnormal_DNA_replication3.30593997
9MP0008932_abnormal_embryonic_tissue3.20246564
10MP0008007_abnormal_cellular_replicative3.02598455
11MP0003718_maternal_effect2.94447386
12MP0003123_paternal_imprinting2.60244205
13MP0003786_premature_aging2.46796888
14MP0009379_abnormal_foot_pigmentation2.30094111
15* MP0001730_embryonic_growth_arrest2.15768814
16MP0008877_abnormal_DNA_methylation2.06554646
17MP0003186_abnormal_redox_activity2.06222031
18MP0004185_abnormal_adipocyte_glucose2.01688967
19MP0000350_abnormal_cell_proliferation1.95139506
20MP0006035_abnormal_mitochondrial_morpho1.85283485
21MP0006036_abnormal_mitochondrial_physio1.81287496
22MP0001529_abnormal_vocalization1.79223724
23MP0003315_abnormal_perineum_morphology1.74843710
24MP0000749_muscle_degeneration1.72428375
25MP0008260_abnormal_autophagy1.59426512
26MP0001697_abnormal_embryo_size1.50126746
27MP0009333_abnormal_splenocyte_physiolog1.49686467
28MP0004233_abnormal_muscle_weight1.48608849
29MP0002160_abnormal_reproductive_system1.47831000
30* MP0002080_prenatal_lethality1.46468747
31MP0004133_heterotaxia1.44115686
32MP0001672_abnormal_embryogenesis/_devel1.37782312
33MP0005380_embryogenesis_phenotype1.37782312
34MP0000313_abnormal_cell_death1.37012944
35MP0005501_abnormal_skin_physiology1.35813238
36MP0003121_genomic_imprinting1.35310996
37MP0005075_abnormal_melanosome_morpholog1.34290565
38MP0000358_abnormal_cell_content/1.33405981
39MP0002396_abnormal_hematopoietic_system1.31703109
40MP0003984_embryonic_growth_retardation1.23830445
41MP0001661_extended_life_span1.22677002
42MP0010030_abnormal_orbit_morphology1.21708920
43MP0002088_abnormal_embryonic_growth/wei1.19774421
44MP0001764_abnormal_homeostasis1.19428629
45MP0005499_abnormal_olfactory_system1.18996858
46MP0005394_taste/olfaction_phenotype1.18996858
47MP0003567_abnormal_fetal_cardiomyocyte1.17413285
48MP0009697_abnormal_copulation1.16808287
49MP0003221_abnormal_cardiomyocyte_apopto1.16786100
50MP0006292_abnormal_olfactory_placode1.16561401
51MP0002085_abnormal_embryonic_tissue1.15707852
52MP0004147_increased_porphyrin_level1.15166776
53MP0002132_abnormal_respiratory_system1.10351162
54MP0000372_irregular_coat_pigmentation1.09738952
55MP0002019_abnormal_tumor_incidence1.08790813
56MP0001905_abnormal_dopamine_level1.07288088
57MP0005389_reproductive_system_phenotype1.07164017
58MP0002751_abnormal_autonomic_nervous1.04577170
59MP0000490_abnormal_crypts_of1.04240741
60MP0003890_abnormal_embryonic-extraembry1.03806209
61MP0002269_muscular_atrophy1.01710178
62MP0000678_abnormal_parathyroid_gland1.00694325
63MP0005266_abnormal_metabolism0.98610588
64MP0008875_abnormal_xenobiotic_pharmacok0.97672213
65MP0002796_impaired_skin_barrier0.96814379
66MP0002163_abnormal_gland_morphology0.92404384
67MP0002210_abnormal_sex_determination0.91573033
68MP0002102_abnormal_ear_morphology0.90459275
69MP0001542_abnormal_bone_strength0.89773244
70MP0002084_abnormal_developmental_patter0.88105123
71MP0002736_abnormal_nociception_after0.87197053
72MP0000647_abnormal_sebaceous_gland0.86443606
73MP0002938_white_spotting0.83458465
74MP0000566_synostosis0.82511226
75MP0005330_cardiomyopathy0.81856022
76MP0001145_abnormal_male_reproductive0.81428990
77MP0001881_abnormal_mammary_gland0.79910770
78MP0005332_abnormal_amino_acid0.77938835
79MP0002653_abnormal_ependyma_morphology0.77273814
80MP0002086_abnormal_extraembryonic_tissu0.76412805
81MP0004197_abnormal_fetal_growth/weight/0.76396448
82MP0004084_abnormal_cardiac_muscle0.76247783
83MP0000747_muscle_weakness0.75346550
84MP0002111_abnormal_tail_morphology0.75227056
85MP0008789_abnormal_olfactory_epithelium0.74602288
86MP0003119_abnormal_digestive_system0.74231634
87MP0000627_abnormal_mammary_gland0.73673787
88MP0005384_cellular_phenotype0.73507064
89MP0001293_anophthalmia0.73284874
90MP0005408_hypopigmentation0.72926514
91MP0005451_abnormal_body_composition0.71015208
92MP0010307_abnormal_tumor_latency0.70843882
93MP0005395_other_phenotype0.69337535
94MP0002722_abnormal_immune_system0.69201617
95MP0010352_gastrointestinal_tract_polyps0.69106833
96MP0000750_abnormal_muscle_regeneration0.68905340
97MP0005319_abnormal_enzyme/_coenzyme0.68779849
98MP0008873_increased_physiological_sensi0.68659652
99MP0000537_abnormal_urethra_morphology0.67087978
100MP0003937_abnormal_limbs/digits/tail_de0.64929528
101MP0000015_abnormal_ear_pigmentation0.64197919
102MP0001919_abnormal_reproductive_system0.63973712
103MP0000689_abnormal_spleen_morphology0.63828522
104MP0000653_abnormal_sex_gland0.63745184
105MP0001853_heart_inflammation0.63365980
106MP0002822_catalepsy0.63058105
107MP0003122_maternal_imprinting0.62846589
108MP0002876_abnormal_thyroid_physiology0.62751885
109MP0001216_abnormal_epidermal_layer0.62531721
110* MP0001727_abnormal_embryo_implantation0.62156986
111MP0001929_abnormal_gametogenesis0.60903395
112MP0000467_abnormal_esophagus_morphology0.60364557
113MP0005376_homeostasis/metabolism_phenot0.59892381
114MP0002877_abnormal_melanocyte_morpholog0.59267487
115MP0000049_abnormal_middle_ear0.59174482
116MP0001119_abnormal_female_reproductive0.58315135
117MP0001188_hyperpigmentation0.57800945
118MP0002098_abnormal_vibrissa_morphology0.57687803
119MP0002177_abnormal_outer_ear0.56620757
120MP0000703_abnormal_thymus_morphology0.56530272
121MP0003646_muscle_fatigue0.56407330
122MP0000858_altered_metastatic_potential0.55436186
123MP0001849_ear_inflammation0.55397641
124MP0001243_abnormal_dermal_layer0.55296862
125MP0002095_abnormal_skin_pigmentation0.55244273
126MP0002429_abnormal_blood_cell0.54768901
127MP0002398_abnormal_bone_marrow0.54282481
128MP0000751_myopathy0.54210747
129MP0001286_abnormal_eye_development0.54148116
130MP0009672_abnormal_birth_weight0.53664406
131MP0003763_abnormal_thymus_physiology0.53517166
132MP0005670_abnormal_white_adipose0.53256609
133MP0010771_integument_phenotype0.53251619
134MP0003941_abnormal_skin_development0.52549393
135MP0003566_abnormal_cell_adhesion0.51103198
136MP0002090_abnormal_vision0.51072965

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.75977127
2Abnormality of glycolysis (HP:0004366)4.70181892
3Increased serum pyruvate (HP:0003542)4.70181892
4Acute necrotizing encephalopathy (HP:0006965)4.57001050
5Cerebral hypomyelination (HP:0006808)4.50620995
6Abnormal mitochondria in muscle tissue (HP:0008316)4.22506298
7Hepatocellular necrosis (HP:0001404)4.20428864
8Mitochondrial inheritance (HP:0001427)4.14689327
9Increased CSF lactate (HP:0002490)4.00789441
10Breast hypoplasia (HP:0003187)3.81993045
11Hepatic necrosis (HP:0002605)3.74024624
12Acute encephalopathy (HP:0006846)3.67240971
13Abnormality of cells of the erythroid lineage (HP:0012130)3.63050837
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.55786422
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.55786422
16Increased serum lactate (HP:0002151)3.47479644
17Rough bone trabeculation (HP:0100670)3.46414335
18Progressive macrocephaly (HP:0004481)3.45593864
19Carpal bone hypoplasia (HP:0001498)3.43322800
20Abnormal number of erythroid precursors (HP:0012131)3.42657830
21Reticulocytopenia (HP:0001896)3.41768098
22Oral leukoplakia (HP:0002745)3.40827069
23Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.32773132
24Abnormal protein N-linked glycosylation (HP:0012347)3.32773132
25Abnormal protein glycosylation (HP:0012346)3.32773132
26Abnormal glycosylation (HP:0012345)3.32773132
27Aplastic anemia (HP:0001915)3.08080611
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.06854883
293-Methylglutaconic aciduria (HP:0003535)3.06320908
30Cholecystitis (HP:0001082)3.05344488
31Abnormal gallbladder physiology (HP:0012438)3.05344488
32Degeneration of anterior horn cells (HP:0002398)3.02716852
33Abnormality of the anterior horn cell (HP:0006802)3.02716852
34Increased hepatocellular lipid droplets (HP:0006565)3.01698252
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.91501664
36Exercise intolerance (HP:0003546)2.88140079
37Hypokinesia (HP:0002375)2.88084266
38Macrocytic anemia (HP:0001972)2.86491809
39Patellar aplasia (HP:0006443)2.81509707
40Lactic acidosis (HP:0003128)2.78564543
41Respiratory failure (HP:0002878)2.74285266
42Lipid accumulation in hepatocytes (HP:0006561)2.70890459
43Aplasia/Hypoplasia of the patella (HP:0006498)2.68817610
44Microvesicular hepatic steatosis (HP:0001414)2.68741271
45Colon cancer (HP:0003003)2.68515979
46Type I transferrin isoform profile (HP:0003642)2.67177774
47Emotional lability (HP:0000712)2.60553876
48Cerebral edema (HP:0002181)2.60396863
49Multiple enchondromatosis (HP:0005701)2.59606187
50CNS demyelination (HP:0007305)2.56447876
51Ependymoma (HP:0002888)2.55679428
52Abnormal trabecular bone morphology (HP:0100671)2.55200147
53Increased muscle lipid content (HP:0009058)2.52834015
54CNS hypomyelination (HP:0003429)2.52325893
55Microretrognathia (HP:0000308)2.51519999
56Abnormality of methionine metabolism (HP:0010901)2.50833534
57Secondary amenorrhea (HP:0000869)2.50072771
58Testicular atrophy (HP:0000029)2.47757655
59Postnatal microcephaly (HP:0005484)2.47639290
60Methylmalonic aciduria (HP:0012120)2.46800740
61Reduced antithrombin III activity (HP:0001976)2.44083220
62Trismus (HP:0000211)2.43718246
63Hypoplasia of the capital femoral epiphysis (HP:0003090)2.39363188
64Agnosia (HP:0010524)2.39101124
65Aplasia/Hypoplasia of the sacrum (HP:0008517)2.38757308
66Selective tooth agenesis (HP:0001592)2.36757806
67Facial cleft (HP:0002006)2.36277469
68Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.35441480
69Irregular epiphyses (HP:0010582)2.35437834
70Exertional dyspnea (HP:0002875)2.30805768
71Premature ovarian failure (HP:0008209)2.29610500
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.26229837
73Pallor (HP:0000980)2.23855442
74Renal Fanconi syndrome (HP:0001994)2.22372638
75Unsteady gait (HP:0002317)2.22139987
76Leukodystrophy (HP:0002415)2.20871743
77Absent radius (HP:0003974)2.20756987
78Meckel diverticulum (HP:0002245)2.20719461
79Respiratory difficulties (HP:0002880)2.20312804
80Poor head control (HP:0002421)2.19981699
81Premature graying of hair (HP:0002216)2.19494871
82Abnormality of the preputium (HP:0100587)2.19346260
83Chromsome breakage (HP:0040012)2.17502934
84Megaloblastic anemia (HP:0001889)2.17009175
85Absent thumb (HP:0009777)2.14101567
86Pancytopenia (HP:0001876)2.12527692
87Abnormality of the ileum (HP:0001549)2.11995864
88Abnormality of the labia minora (HP:0012880)2.11470724
89Bone marrow hypocellularity (HP:0005528)2.11276793
90Hypoplastic pelvis (HP:0008839)2.11176074
91Cellular immunodeficiency (HP:0005374)2.10579299
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08295611
93Abnormality of alanine metabolism (HP:0010916)2.08295611
94Hyperalaninemia (HP:0003348)2.08295611
95Increased intramyocellular lipid droplets (HP:0012240)2.06678708
9611 pairs of ribs (HP:0000878)2.05727639
97Large for gestational age (HP:0001520)2.05636283
98Delusions (HP:0000746)2.05127005
99Horseshoe kidney (HP:0000085)2.02904237
100Aplasia involving forearm bones (HP:0009822)2.02491407
101Absent forearm bone (HP:0003953)2.02491407
102Upper limb muscle weakness (HP:0003484)2.01471038
103Aplasia/Hypoplasia involving the musculature (HP:0001460)2.00001860
104Neoplasm of the adrenal gland (HP:0100631)1.99301066
105Glossoptosis (HP:0000162)1.99019756
106Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.98291370
107Absent epiphyses (HP:0010577)1.98291370
108Progressive muscle weakness (HP:0003323)1.97546537
109Optic disc pallor (HP:0000543)1.95814552
110Medulloblastoma (HP:0002885)1.95690459
111Ragged-red muscle fibers (HP:0003200)1.94314573
112Type 2 muscle fiber atrophy (HP:0003554)1.93625442
113Generalized aminoaciduria (HP:0002909)1.93473226
114Sparse eyelashes (HP:0000653)1.93406526
115Impulsivity (HP:0100710)1.93108375
116Opisthotonus (HP:0002179)1.92746396
117Abnormalities of placenta or umbilical cord (HP:0001194)1.91738387
118Atrophy/Degeneration involving motor neurons (HP:0007373)1.90431009
119Neoplasm of the pancreas (HP:0002894)1.89364080
120Muscle fiber atrophy (HP:0100295)1.86662557
121Lethargy (HP:0001254)1.86428879
122Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.85882593
123Stenosis of the external auditory canal (HP:0000402)1.85733827
124Aplasia/Hypoplasia of the uvula (HP:0010293)1.85660144
125Reduced subcutaneous adipose tissue (HP:0003758)1.84952602
126Triphalangeal thumb (HP:0001199)1.84505685
127Abnormality of placental membranes (HP:0011409)1.83580088
128Amniotic constriction ring (HP:0009775)1.83580088
129Abnormal number of incisors (HP:0011064)1.83307220
130Congenital ichthyosiform erythroderma (HP:0007431)1.83022073
131Abnormality of the umbilical cord (HP:0010881)1.82327544
132Abnormal lung lobation (HP:0002101)1.80308522
133Cleft eyelid (HP:0000625)1.80204300
134Shoulder girdle muscle weakness (HP:0003547)1.76407599
135Death in infancy (HP:0001522)1.75861574
136Abnormality of the astrocytes (HP:0100707)1.69026282
137Astrocytoma (HP:0009592)1.69026282
138Late onset (HP:0003584)1.68063746
139Dicarboxylic aciduria (HP:0003215)1.67637405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.95050578
2WEE14.11353060
3VRK23.90419217
4STK163.73775660
5EIF2AK13.70312254
6TRIB33.34937379
7TSSK63.29520624
8SRPK12.65084767
9PLK42.50652772
10CDC72.42815508
11NME22.38284236
12EIF2AK32.38090645
13NEK12.23561608
14VRK12.03389507
15TESK21.99594461
16TRIM281.82935462
17NME11.82778551
18EPHA21.72905014
19PLK31.72214603
20CCNB11.70057355
21PLK11.60698538
22PIM21.59847839
23TTK1.48056754
24BRSK21.47549230
25PBK1.47057971
26ACVR1B1.44163117
27AURKA1.42197962
28MKNK11.41524184
29ZAK1.39315897
30NEK21.32641104
31TLK11.32135896
32BRAF1.28971562
33ARAF1.28959338
34RPS6KB21.24433797
35CDK91.24386473
36AURKB1.23356243
37KDR1.23116747
38PASK1.21922553
39SMG11.21718410
40BRSK11.19580421
41TESK11.12555210
42MAP3K121.06676485
43DYRK31.05108233
44ATR1.04575839
45CDK70.99880845
46PNCK0.99655558
47CSNK1A1L0.97943483
48AKT30.96761031
49TAF10.95980588
50LIMK10.94280884
51PAK40.94249354
52CHEK20.93397179
53MST1R0.92866926
54NUAK10.92171351
55DYRK20.89964627
56MAP3K80.88717712
57DAPK10.88265509
58MST40.86847441
59BCKDK0.86668224
60BCR0.85759488
61CSNK1G10.85225744
62MYLK0.83098784
63EIF2AK20.81600696
64PRKCI0.80168285
65MAP3K110.80133691
66MAPKAPK50.80087002
67CSNK2A10.79766252
68SCYL20.72456673
69CSNK2A20.72404420
70CSNK1G20.72396296
71STK38L0.71363762
72PAK10.70835153
73RPS6KA40.69843069
74PLK20.69775528
75STK100.69408230
76CHEK10.69255671
77MKNK20.67055202
78CDK80.61669996
79TAOK20.60294778
80PDK30.54624113
81PDK40.54624113
82CASK0.54013238
83TGFBR10.52426481
84MAP2K70.52420694
85MET0.50894324
86ABL20.50612804
87STK40.50455286
88MAPKAPK30.50440372
89OBSCN0.50187095
90ERBB40.49690926
91MAP4K20.49335974
92CDK40.49014776
93CSNK1G30.48209723
94SIK30.47733840
95MAP3K30.47220991
96PDK20.46982197
97ILK0.45560233
98LMTK20.44880469
99CDK190.44498729
100RPS6KA50.43475630
101YES10.43148635
102CDK20.42438584
103PIM10.42254201
104CAMK2G0.38570902
105BLK0.38126356
106IRAK30.37958340
107DAPK30.36358713
108ERBB30.35901940
109CDK10.34886953
110ATM0.31908240
111ALK0.31751705
112WNK30.29900519
113PTK20.29859618
114FLT30.29598530
115AKT20.27856775
116CLK10.27086025
117CDK180.25868717
118GRK60.25570654
119MAP2K60.25377070
120CDK140.25260490
121CSNK1E0.25134403
122ZAP700.24911945
123PAK60.24223375
124CDK150.24090363
125ADRBK20.24089573
126CDK11A0.24016379
127MAP2K30.23933796
128IRAK40.23878820

Predicted pathways (KEGG)

RankGene SetZ-score
1* Proteasome_Homo sapiens_hsa030505.44119296
2DNA replication_Homo sapiens_hsa030304.07306286
3RNA polymerase_Homo sapiens_hsa030203.81356367
4Ribosome_Homo sapiens_hsa030103.68207136
5Mismatch repair_Homo sapiens_hsa034303.64712338
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.28653748
7Spliceosome_Homo sapiens_hsa030402.95425725
8Pyrimidine metabolism_Homo sapiens_hsa002402.68126257
9RNA transport_Homo sapiens_hsa030132.59012400
10Homologous recombination_Homo sapiens_hsa034402.53880772
11Nucleotide excision repair_Homo sapiens_hsa034202.52363089
12Oxidative phosphorylation_Homo sapiens_hsa001902.49979153
13Base excision repair_Homo sapiens_hsa034102.49437468
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.43238969
15Parkinsons disease_Homo sapiens_hsa050122.23101153
16One carbon pool by folate_Homo sapiens_hsa006702.01206061
17Cell cycle_Homo sapiens_hsa041101.84675848
18Huntingtons disease_Homo sapiens_hsa050161.77040979
19Basal transcription factors_Homo sapiens_hsa030221.70481193
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61612367
21Fanconi anemia pathway_Homo sapiens_hsa034601.59277084
22Purine metabolism_Homo sapiens_hsa002301.53225276
23Sulfur metabolism_Homo sapiens_hsa009201.52415156
24Protein export_Homo sapiens_hsa030601.49852572
25RNA degradation_Homo sapiens_hsa030181.45160447
26Non-homologous end-joining_Homo sapiens_hsa034501.38089812
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.35425158
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31649772
29Alzheimers disease_Homo sapiens_hsa050101.28132711
30Folate biosynthesis_Homo sapiens_hsa007901.23561284
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22870215
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17601230
33Biosynthesis of amino acids_Homo sapiens_hsa012301.16536812
34* Epstein-Barr virus infection_Homo sapiens_hsa051691.16104541
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14339756
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13225307
37Vitamin B6 metabolism_Homo sapiens_hsa007501.12868753
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10888366
39Pentose phosphate pathway_Homo sapiens_hsa000301.04376094
40Carbon metabolism_Homo sapiens_hsa012001.00929482
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.98621263
42mRNA surveillance pathway_Homo sapiens_hsa030150.90672179
43Glutathione metabolism_Homo sapiens_hsa004800.87660350
44p53 signaling pathway_Homo sapiens_hsa041150.87659694
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85146024
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83559602
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83017661
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79066185
49Fructose and mannose metabolism_Homo sapiens_hsa000510.76259946
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75728452
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71491978
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.71034495
53Systemic lupus erythematosus_Homo sapiens_hsa053220.70683030
54Pyruvate metabolism_Homo sapiens_hsa006200.69946319
55Collecting duct acid secretion_Homo sapiens_hsa049660.68931624
56Metabolic pathways_Homo sapiens_hsa011000.65139485
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63675709
58Sulfur relay system_Homo sapiens_hsa041220.60526666
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58570405
60Regulation of autophagy_Homo sapiens_hsa041400.57630233
61Oocyte meiosis_Homo sapiens_hsa041140.57437396
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53437667
63Vibrio cholerae infection_Homo sapiens_hsa051100.50407363
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49341928
65Antigen processing and presentation_Homo sapiens_hsa046120.46703454
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43782557
67Cardiac muscle contraction_Homo sapiens_hsa042600.43005302
68Viral carcinogenesis_Homo sapiens_hsa052030.42696671
69Fatty acid elongation_Homo sapiens_hsa000620.41740039
70Legionellosis_Homo sapiens_hsa051340.41276459
71Fatty acid metabolism_Homo sapiens_hsa012120.40557414
72Arginine and proline metabolism_Homo sapiens_hsa003300.39638361
73Selenocompound metabolism_Homo sapiens_hsa004500.38589687
74Phenylalanine metabolism_Homo sapiens_hsa003600.33266053
75Galactose metabolism_Homo sapiens_hsa000520.33174263
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32726217
77Herpes simplex infection_Homo sapiens_hsa051680.32085054
78Arachidonic acid metabolism_Homo sapiens_hsa005900.29061875
79beta-Alanine metabolism_Homo sapiens_hsa004100.28518734
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28274590
81N-Glycan biosynthesis_Homo sapiens_hsa005100.27295969
82Steroid biosynthesis_Homo sapiens_hsa001000.27122098
83Tyrosine metabolism_Homo sapiens_hsa003500.24772159
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24555562
85Arginine biosynthesis_Homo sapiens_hsa002200.24402277
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23871547
87HTLV-I infection_Homo sapiens_hsa051660.18955007
88Phagosome_Homo sapiens_hsa041450.17585272
89Alcoholism_Homo sapiens_hsa050340.16153405
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.15722632
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.14563716
92Rheumatoid arthritis_Homo sapiens_hsa053230.14264556
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13070721
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12939421
95Shigellosis_Homo sapiens_hsa051310.11809972
96Allograft rejection_Homo sapiens_hsa053300.10587137
97Vitamin digestion and absorption_Homo sapiens_hsa049770.10345554
98Primary immunodeficiency_Homo sapiens_hsa053400.07931124
99Type I diabetes mellitus_Homo sapiens_hsa049400.06999425
100Peroxisome_Homo sapiens_hsa041460.06042746
101Graft-versus-host disease_Homo sapiens_hsa053320.06019060
102Propanoate metabolism_Homo sapiens_hsa006400.05800533
103Thyroid cancer_Homo sapiens_hsa052160.05352062
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.04723943
105Fatty acid degradation_Homo sapiens_hsa000710.03629314
106Autoimmune thyroid disease_Homo sapiens_hsa053200.03224114
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.02710869
108Tryptophan metabolism_Homo sapiens_hsa003800.02265552
109Renin-angiotensin system_Homo sapiens_hsa046140.02178908
110Apoptosis_Homo sapiens_hsa042100.01855683
111Tight junction_Homo sapiens_hsa045300.01792123
112HIF-1 signaling pathway_Homo sapiens_hsa040660.01555755
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.00520491
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0159929
115Chemical carcinogenesis_Homo sapiens_hsa05204-0.0045374

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