PSMC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.46757121
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.78750722
3ATP synthesis coupled proton transport (GO:0015986)5.78750722
4cullin deneddylation (GO:0010388)5.50227296
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.26472148
6proteasome assembly (GO:0043248)5.20454966
7protein deneddylation (GO:0000338)5.01736589
8chaperone-mediated protein transport (GO:0072321)4.77670717
9DNA strand elongation involved in DNA replication (GO:0006271)4.67699792
10DNA unwinding involved in DNA replication (GO:0006268)4.65971533
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.60824984
12* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.58884672
13DNA strand elongation (GO:0022616)4.52520332
14* regulation of cellular amino acid metabolic process (GO:0006521)4.38820784
15protein neddylation (GO:0045116)4.35915713
16* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.34898133
17respiratory electron transport chain (GO:0022904)4.25590908
18* negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.19360055
19* negative regulation of ligase activity (GO:0051352)4.19360055
20electron transport chain (GO:0022900)4.16624423
21* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.16046750
22* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.15438679
23L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.13021224
24* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.00530048
25formation of translation preinitiation complex (GO:0001731)3.96987861
26* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.92965396
27* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.92965396
28telomere maintenance via semi-conservative replication (GO:0032201)3.92612296
29protein maturation by protein folding (GO:0022417)3.91009438
30* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.90623295
31* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.90623295
32* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.90623295
33* signal transduction involved in DNA damage checkpoint (GO:0072422)3.86132853
34* signal transduction involved in DNA integrity checkpoint (GO:0072401)3.86132853
35regulation of mitochondrial translation (GO:0070129)3.84075275
36* signal transduction involved in cell cycle checkpoint (GO:0072395)3.82176565
37termination of RNA polymerase III transcription (GO:0006386)3.80299784
38transcription elongation from RNA polymerase III promoter (GO:0006385)3.80299784
39* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.79816278
40ribosomal small subunit biogenesis (GO:0042274)3.77023901
41nucleobase biosynthetic process (GO:0046112)3.65602997
427-methylguanosine mRNA capping (GO:0006370)3.64194639
43protein complex biogenesis (GO:0070271)3.63321857
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.62902268
45NADH dehydrogenase complex assembly (GO:0010257)3.62902268
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.62902268
47establishment of protein localization to mitochondrion (GO:0072655)3.62436331
48mitotic sister chromatid segregation (GO:0000070)3.61874147
49purine nucleobase biosynthetic process (GO:0009113)3.59079628
50* positive regulation of ligase activity (GO:0051351)3.56706829
517-methylguanosine RNA capping (GO:0009452)3.54232003
52RNA capping (GO:0036260)3.54232003
53oxidative phosphorylation (GO:0006119)3.52180683
54ribosomal small subunit assembly (GO:0000028)3.46256770
55protein targeting to mitochondrion (GO:0006626)3.45751677
56* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.45653018
57mitochondrial respiratory chain complex assembly (GO:0033108)3.43644118
58L-methionine salvage (GO:0071267)3.42377821
59L-methionine biosynthetic process (GO:0071265)3.42377821
60amino acid salvage (GO:0043102)3.42377821
61* regulation of cellular amine metabolic process (GO:0033238)3.42114119
62establishment of integrated proviral latency (GO:0075713)3.39176004
63ATP hydrolysis coupled proton transport (GO:0015991)3.37734568
64energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.37734568
65protein localization to mitochondrion (GO:0070585)3.35352100
66histone arginine methylation (GO:0034969)3.34191678
67spliceosomal snRNP assembly (GO:0000387)3.33375054
68* regulation of ubiquitin-protein transferase activity (GO:0051438)3.33073018
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.30907240
70translation (GO:0006412)3.28868754
71viral transcription (GO:0019083)3.27156230
72mitotic metaphase plate congression (GO:0007080)3.26836599
73SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.25519456
74ribosome assembly (GO:0042255)3.25307236
75IMP biosynthetic process (GO:0006188)3.25073049
76DNA replication initiation (GO:0006270)3.24218726
77de novo protein folding (GO:0006458)3.22940481
78pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.21803143
79cotranslational protein targeting to membrane (GO:0006613)3.20662435
80NADH metabolic process (GO:0006734)3.20602075
81protein targeting to ER (GO:0045047)3.19785557
82translational termination (GO:0006415)3.17191637
83ribosome biogenesis (GO:0042254)3.16621450
84peptidyl-arginine omega-N-methylation (GO:0035247)3.16330199
85DNA replication checkpoint (GO:0000076)3.15960620
86* regulation of ligase activity (GO:0051340)3.15710878
87de novo posttranslational protein folding (GO:0051084)3.14876658
88guanosine-containing compound biosynthetic process (GO:1901070)3.13010936
89* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.11872062
90ATP biosynthetic process (GO:0006754)3.10418967
91* positive regulation of cell cycle arrest (GO:0071158)3.09422815
92pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.08952812
93telomere maintenance via recombination (GO:0000722)3.08811675
94nuclear envelope reassembly (GO:0031468)3.08502719
95mitotic nuclear envelope reassembly (GO:0007084)3.08502719
96protein localization to endoplasmic reticulum (GO:0070972)3.06377737
97rRNA processing (GO:0006364)3.06372584
98establishment of protein localization to endoplasmic reticulum (GO:0072599)3.04757209
99sister chromatid segregation (GO:0000819)3.04720775
100purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.04673171
101inner mitochondrial membrane organization (GO:0007007)3.04460780
102UTP biosynthetic process (GO:0006228)3.03523033
103translational elongation (GO:0006414)3.03267204
104viral mRNA export from host cell nucleus (GO:0046784)3.02052269
105respiratory chain complex IV assembly (GO:0008535)3.01459933
106tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.00751664
107RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.00751664
108* negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.00449633
109protein-cofactor linkage (GO:0018065)2.99742158
110maturation of 5.8S rRNA (GO:0000460)2.99260303
111purine nucleoside triphosphate biosynthetic process (GO:0009145)2.98784927
112* DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.95332033
113cellular component biogenesis (GO:0044085)2.94942216
114rRNA modification (GO:0000154)2.92579695
115establishment of viral latency (GO:0019043)2.91250188
116maturation of SSU-rRNA (GO:0030490)2.90591216
117negative regulation of microtubule polymerization (GO:0031115)2.90526770
118spliceosomal complex assembly (GO:0000245)2.89673236
119ribonucleoprotein complex biogenesis (GO:0022613)2.87094620
120* G1/S transition of mitotic cell cycle (GO:0000082)2.85570359
121* cell cycle G1/S phase transition (GO:0044843)2.85570359
122* negative regulation of protein ubiquitination (GO:0031397)2.84899672
123tricarboxylic acid cycle (GO:0006099)2.84655918
124GTP biosynthetic process (GO:0006183)2.84562881
125peptidyl-histidine modification (GO:0018202)2.84100783
126nucleobase-containing small molecule interconversion (GO:0015949)2.83699921
127transferrin transport (GO:0033572)2.80538121
128hydrogen ion transmembrane transport (GO:1902600)2.79891300
129transcription elongation from RNA polymerase I promoter (GO:0006362)2.77149239
130ribonucleoside triphosphate biosynthetic process (GO:0009201)2.76531638
131ribosomal large subunit biogenesis (GO:0042273)2.75682602
132transcription-coupled nucleotide-excision repair (GO:0006283)2.75539412
133pseudouridine synthesis (GO:0001522)2.72949945

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.75880650
2* EST1_17652178_ChIP-ChIP_JURKAT_Human4.15511036
3* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.12319038
4* GABP_17652178_ChIP-ChIP_JURKAT_Human4.03675421
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.97532184
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.95434290
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.86094933
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.61973213
9* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58722713
10* HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.45116611
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.39891076
12THAP11_20581084_ChIP-Seq_MESCs_Mouse2.98696215
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.97659523
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95309547
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.87944712
16* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.87141749
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81431771
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71088566
19E2F7_22180533_ChIP-Seq_HELA_Human2.67707097
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.52387328
21* YY1_21170310_ChIP-Seq_MESCs_Mouse2.38687283
22VDR_23849224_ChIP-Seq_CD4+_Human2.32532322
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.27020536
24XRN2_22483619_ChIP-Seq_HELA_Human2.25461106
25DCP1A_22483619_ChIP-Seq_HELA_Human2.23077325
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23071700
27* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.13135056
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12609401
29* SRF_21415370_ChIP-Seq_HL-1_Mouse2.05538424
30GABP_19822575_ChIP-Seq_HepG2_Human2.05169880
31E2F4_17652178_ChIP-ChIP_JURKAT_Human2.02060335
32TTF2_22483619_ChIP-Seq_HELA_Human1.95621207
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.95609836
34* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92981866
35FOXP3_21729870_ChIP-Seq_TREG_Human1.87209400
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83764023
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73367627
38ELK1_19687146_ChIP-ChIP_HELA_Human1.70316611
39ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.66867206
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64712545
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64175949
42DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.62112625
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.58909940
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57830389
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.55469724
46* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53782632
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50605125
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47199042
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46856099
50SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.46698745
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45960787
52* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42765299
53ZNF263_19887448_ChIP-Seq_K562_Human1.42073227
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37845884
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36650521
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35759641
57CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.34518422
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34018066
59* ELK1_22589737_ChIP-Seq_MCF10A_Human1.33510658
60* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33300455
61* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30087082
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28149499
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23098474
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20328532
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17230252
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15487405
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15406825
68KDM5A_27292631_Chip-Seq_BREAST_Human1.14901061
69* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13355171
70AR_21909140_ChIP-Seq_LNCAP_Human1.13229016
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12311889
72* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12183028
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12181554
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11154301
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10454674
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10022572
77* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07380749
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06915569
79SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06132330
80FOXP1_21924763_ChIP-Seq_HESCs_Human1.04081405
81TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02546482
82VDR_22108803_ChIP-Seq_LS180_Human1.01298669
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01268293
84TET1_21451524_ChIP-Seq_MESCs_Mouse1.00714121
85NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.00463108
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00304862
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00082752
88NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99343325
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98487458
90* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98160834
91SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98002385
92TFEB_21752829_ChIP-Seq_HELA_Human0.97960624
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96802138
94OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96480075
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96269477
96* CIITA_25753668_ChIP-Seq_RAJI_Human0.94661675
97MYC_18940864_ChIP-ChIP_HL60_Human0.94579109
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.90179681
99* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90028503
100* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89583370
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88158762
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86852149
103SOX2_16153702_ChIP-ChIP_HESCs_Human0.86530518
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85850421
105REST_18959480_ChIP-ChIP_MESCs_Mouse0.85607612
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.85569445
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85165041
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84418818
109CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84305218
110SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84246729
111EZH2_22144423_ChIP-Seq_EOC_Human0.81838879
112TAF15_26573619_Chip-Seq_HEK293_Human0.81835080
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79114015
114FOXM1_23109430_ChIP-Seq_U2OS_Human0.77692043
115YY1_22570637_ChIP-Seq_MALME-3M_Human0.77515952
116TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.77302324
117ESR1_15608294_ChIP-ChIP_MCF-7_Human0.75635357
118NANOG_16153702_ChIP-ChIP_HESCs_Human0.74716148
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74668700
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.74625703
121FUS_26573619_Chip-Seq_HEK293_Human0.73519663
122STAT3_1855785_ChIP-Seq_MESCs_Mouse0.72254119
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.72034327

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.76093289
2MP0001529_abnormal_vocalization3.40784571
3MP0008007_abnormal_cellular_replicative2.91779633
4MP0003693_abnormal_embryo_hatching2.80268813
5MP0003186_abnormal_redox_activity2.65694469
6MP0004957_abnormal_blastocyst_morpholog2.60528019
7MP0003123_paternal_imprinting2.59755838
8MP0006276_abnormal_autonomic_nervous2.39187215
9MP0003122_maternal_imprinting2.37974829
10MP0001905_abnormal_dopamine_level2.31014860
11MP0001968_abnormal_touch/_nociception2.26832277
12MP0002736_abnormal_nociception_after2.26246866
13MP0002822_catalepsy2.25880366
14MP0009046_muscle_twitch2.18209334
15MP0008932_abnormal_embryonic_tissue2.04950083
16MP0002734_abnormal_mechanical_nocicepti1.99246475
17MP0002064_seizures1.97350119
18MP0006035_abnormal_mitochondrial_morpho1.96743415
19MP0008877_abnormal_DNA_methylation1.96523578
20MP0004270_analgesia1.95343509
21MP0004859_abnormal_synaptic_plasticity1.93913539
22MP0001440_abnormal_grooming_behavior1.90790362
23MP0003635_abnormal_synaptic_transmissio1.90479881
24MP0002735_abnormal_chemical_nociception1.80897524
25MP0009745_abnormal_behavioral_response1.79472243
26MP0003111_abnormal_nucleus_morphology1.78598203
27MP0002272_abnormal_nervous_system1.76105203
28MP0010094_abnormal_chromosome_stability1.72064108
29MP0004142_abnormal_muscle_tone1.71819826
30MP0005408_hypopigmentation1.71008253
31MP0008058_abnormal_DNA_repair1.68744910
32MP0003718_maternal_effect1.65985847
33MP0002653_abnormal_ependyma_morphology1.65301758
34MP0008057_abnormal_DNA_replication1.62264755
35MP0002572_abnormal_emotion/affect_behav1.60227879
36MP0003121_genomic_imprinting1.59429504
37MP0001984_abnormal_olfaction1.57780309
38MP0003806_abnormal_nucleotide_metabolis1.57691065
39MP0002063_abnormal_learning/memory/cond1.56770906
40MP0006036_abnormal_mitochondrial_physio1.56262299
41MP0003077_abnormal_cell_cycle1.53496629
42MP0002080_prenatal_lethality1.47537963
43MP0005501_abnormal_skin_physiology1.44444460
44MP0001970_abnormal_pain_threshold1.43272361
45MP0002733_abnormal_thermal_nociception1.39625749
46MP0002067_abnormal_sensory_capabilities1.38642132
47MP0002184_abnormal_innervation1.38488743
48MP0005499_abnormal_olfactory_system1.38116809
49MP0005394_taste/olfaction_phenotype1.38116809
50MP0002751_abnormal_autonomic_nervous1.37716034
51MP0000313_abnormal_cell_death1.37649788
52MP0002837_dystrophic_cardiac_calcinosis1.36505097
53MP0006292_abnormal_olfactory_placode1.36250369
54MP0003786_premature_aging1.34257480
55MP0003315_abnormal_perineum_morphology1.33640102
56MP0002938_white_spotting1.30838411
57MP0004924_abnormal_behavior1.29994003
58MP0005386_behavior/neurological_phenoty1.29994003
59MP0002160_abnormal_reproductive_system1.29536057
60MP0008789_abnormal_olfactory_epithelium1.27930599
61MP0001727_abnormal_embryo_implantation1.26203658
62MP0004133_heterotaxia1.25485646
63MP0001730_embryonic_growth_arrest1.25475290
64MP0002796_impaired_skin_barrier1.24047322
65MP0002638_abnormal_pupillary_reflex1.22907963
66MP0008260_abnormal_autophagy1.21598429
67MP0009672_abnormal_birth_weight1.20993393
68MP0000566_synostosis1.20907935
69MP0004145_abnormal_muscle_electrophysio1.19196535
70MP0001501_abnormal_sleep_pattern1.18744282
71MP0009697_abnormal_copulation1.17601667
72MP0005075_abnormal_melanosome_morpholog1.15952241
73MP0002877_abnormal_melanocyte_morpholog1.14673498
74MP0000751_myopathy1.14311117
75MP0002085_abnormal_embryonic_tissue1.14296963
76MP0005380_embryogenesis_phenotype1.12402094
77MP0001672_abnormal_embryogenesis/_devel1.12402094
78MP0000749_muscle_degeneration1.09495905
79MP0004233_abnormal_muscle_weight1.06198159
80MP0000372_irregular_coat_pigmentation1.04184071
81MP0002210_abnormal_sex_determination1.02369435
82MP0005058_abnormal_lysosome_morphology1.00777615
83MP0001486_abnormal_startle_reflex0.99775216
84MP0002876_abnormal_thyroid_physiology0.99559989
85MP0002163_abnormal_gland_morphology0.98543563
86MP0001293_anophthalmia0.97191980
87MP0000778_abnormal_nervous_system0.97096218
88MP0003329_amyloid_beta_deposits0.96327161
89MP0008872_abnormal_physiological_respon0.96259516
90MP0000358_abnormal_cell_content/0.95938603
91MP0002102_abnormal_ear_morphology0.94909512
92MP0002066_abnormal_motor_capabilities/c0.94822381
93MP0001853_heart_inflammation0.94454260
94MP0003941_abnormal_skin_development0.94185901
95MP0001188_hyperpigmentation0.92790405
96MP0006072_abnormal_retinal_apoptosis0.92556157
97MP0000579_abnormal_nail_morphology0.92552776
98MP0001346_abnormal_lacrimal_gland0.91715260
99MP0005423_abnormal_somatic_nervous0.91390349
100MP0002019_abnormal_tumor_incidence0.91276445
101MP0001661_extended_life_span0.91098391
102MP0002882_abnormal_neuron_morphology0.90197519
103MP0003646_muscle_fatigue0.89912845
104MP0004811_abnormal_neuron_physiology0.89756397
105MP0003984_embryonic_growth_retardation0.88645700
106MP0003011_delayed_dark_adaptation0.88594628
107MP0005646_abnormal_pituitary_gland0.86322131
108MP0002088_abnormal_embryonic_growth/wei0.84860623
109MP0010386_abnormal_urinary_bladder0.84448608
110MP0002084_abnormal_developmental_patter0.84184882
111MP0004036_abnormal_muscle_relaxation0.84015055
112MP0005384_cellular_phenotype0.83953474
113MP0005266_abnormal_metabolism0.83417946
114MP0001986_abnormal_taste_sensitivity0.83196689
115MP0004084_abnormal_cardiac_muscle0.83047829
116MP0002557_abnormal_social/conspecific_i0.82666666
117MP0001764_abnormal_homeostasis0.82400148
118MP0001881_abnormal_mammary_gland0.82337603
119MP0001485_abnormal_pinna_reflex0.82108186
120MP0000955_abnormal_spinal_cord0.80863696
121MP0000537_abnormal_urethra_morphology0.79937301
122MP0010030_abnormal_orbit_morphology0.79031486
123MP0002752_abnormal_somatic_nervous0.78935636
124MP0003787_abnormal_imprinting0.78843190
125MP0000490_abnormal_crypts_of0.78278719
126MP0005389_reproductive_system_phenotype0.78113552
127MP0000350_abnormal_cell_proliferation0.77076351
128MP0003879_abnormal_hair_cell0.76006616
129MP0002269_muscular_atrophy0.75227280
130MP0004147_increased_porphyrin_level0.74918530
131MP0001697_abnormal_embryo_size0.74253220
132MP0001929_abnormal_gametogenesis0.73862331
133MP0000747_muscle_weakness0.73513081
134MP0002152_abnormal_brain_morphology0.73512958
135MP0005645_abnormal_hypothalamus_physiol0.73226582
136MP0001145_abnormal_male_reproductive0.71467642
137MP0005330_cardiomyopathy0.71008127
138MP0004215_abnormal_myocardial_fiber0.70801535
139MP0008995_early_reproductive_senescence0.70737416
140MP0009379_abnormal_foot_pigmentation0.70332061
141MP0003942_abnormal_urinary_system0.68211321
142MP0009333_abnormal_splenocyte_physiolog0.67731964
143MP0004197_abnormal_fetal_growth/weight/0.65509596
144MP0002111_abnormal_tail_morphology0.65003595
145MP0009053_abnormal_anal_canal0.63498284
146MP0000653_abnormal_sex_gland0.61788675
147MP0000627_abnormal_mammary_gland0.61243869
148MP0001186_pigmentation_phenotype0.59175524
149MP0005379_endocrine/exocrine_gland_phen0.56012079
150MP0010771_integument_phenotype0.54764059
151MP0005083_abnormal_biliary_tract0.54201526
152MP0001919_abnormal_reproductive_system0.53989954
153MP0002970_abnormal_white_adipose0.53864080
154MP0002909_abnormal_adrenal_gland0.53781113
155MP0008875_abnormal_xenobiotic_pharmacok0.53751439
156MP0003937_abnormal_limbs/digits/tail_de0.52174566
157MP0003938_abnormal_ear_development0.52118306
158MP0003136_yellow_coat_color0.51020723

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.85391823
2Abnormal mitochondria in muscle tissue (HP:0008316)5.48350152
3Mitochondrial inheritance (HP:0001427)4.96526802
4Abnormality of glycolysis (HP:0004366)4.79443879
5Increased serum pyruvate (HP:0003542)4.79443879
6Progressive macrocephaly (HP:0004481)4.76342766
7Increased CSF lactate (HP:0002490)4.55049110
8Acute encephalopathy (HP:0006846)4.54677656
9Cerebral hypomyelination (HP:0006808)4.32098685
10Hepatocellular necrosis (HP:0001404)4.31200812
11Hepatic necrosis (HP:0002605)3.59180532
12Increased hepatocellular lipid droplets (HP:0006565)3.42974322
13Increased serum lactate (HP:0002151)3.24409190
14Type I transferrin isoform profile (HP:0003642)3.23664140
15Abnormality of the labia minora (HP:0012880)3.21202640
16Exercise intolerance (HP:0003546)3.19922372
17Respiratory failure (HP:0002878)3.11421376
18Reticulocytopenia (HP:0001896)3.11184543
19Testicular atrophy (HP:0000029)3.04236334
20Leukodystrophy (HP:0002415)3.03896656
21Birth length less than 3rd percentile (HP:0003561)3.02962228
22Lactic acidosis (HP:0003128)3.01875780
23Delusions (HP:0000746)3.00588576
24Pheochromocytoma (HP:0002666)3.00167374
25Progressive muscle weakness (HP:0003323)2.99690825
26Neuroendocrine neoplasm (HP:0100634)2.99091835
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.98998443
28Cerebral edema (HP:0002181)2.95871119
29Emotional lability (HP:0000712)2.94291518
30Lipid accumulation in hepatocytes (HP:0006561)2.90983075
31Focal motor seizures (HP:0011153)2.84869452
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.81411008
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.81411008
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.76401419
35Optic disc pallor (HP:0000543)2.74610514
36CNS demyelination (HP:0007305)2.72601718
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.71667337
38Myokymia (HP:0002411)2.70374022
39Breast hypoplasia (HP:0003187)2.66055361
40CNS hypomyelination (HP:0003429)2.59579622
41Atonic seizures (HP:0010819)2.58785179
42Macrocytic anemia (HP:0001972)2.50781297
43Pancytopenia (HP:0001876)2.48975190
44Opisthotonus (HP:0002179)2.48902143
45Increased intramyocellular lipid droplets (HP:0012240)2.48336627
46Sparse eyelashes (HP:0000653)2.48239929
47Congenital primary aphakia (HP:0007707)2.48189869
48Renal Fanconi syndrome (HP:0001994)2.47642190
49Gait imbalance (HP:0002141)2.44219501
50Chromsome breakage (HP:0040012)2.43676725
51Abnormal protein glycosylation (HP:0012346)2.42757505
52Abnormal glycosylation (HP:0012345)2.42757505
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42757505
54Abnormal protein N-linked glycosylation (HP:0012347)2.42757505
55Poor suck (HP:0002033)2.41027868
563-Methylglutaconic aciduria (HP:0003535)2.40011358
57Unsteady gait (HP:0002317)2.39398388
58Abnormality of the preputium (HP:0100587)2.38935054
59Medial flaring of the eyebrow (HP:0010747)2.37562063
60Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.36645162
61Postnatal microcephaly (HP:0005484)2.36583655
62Multiple enchondromatosis (HP:0005701)2.36246923
63Ragged-red muscle fibers (HP:0003200)2.34013213
64Aplastic anemia (HP:0001915)2.32578083
65Hypokinesia (HP:0002375)2.28165912
66Abnormality of cochlea (HP:0000375)2.28120043
67Nephrogenic diabetes insipidus (HP:0009806)2.27732057
68Reduced antithrombin III activity (HP:0001976)2.26372953
69Microretrognathia (HP:0000308)2.24312418
70Aplasia/Hypoplasia of the sacrum (HP:0008517)2.22389722
71Facial cleft (HP:0002006)2.22126920
72Meckel diverticulum (HP:0002245)2.21338548
73Carpal bone hypoplasia (HP:0001498)2.13710030
74Abnormality of the anterior horn cell (HP:0006802)2.07853631
75Degeneration of anterior horn cells (HP:0002398)2.07853631
76Absence seizures (HP:0002121)2.05953610
77Rough bone trabeculation (HP:0100670)2.04594123
78Abnormality of the ileum (HP:0001549)2.03394609
79Abnormal trabecular bone morphology (HP:0100671)2.03381380
80Limb dystonia (HP:0002451)2.03331504
81Respiratory difficulties (HP:0002880)1.98173193
82Vaginal atresia (HP:0000148)1.96620107
83Shoulder girdle muscle weakness (HP:0003547)1.95832024
84Abnormal autonomic nervous system physiology (HP:0012332)1.94997936
85Dialeptic seizures (HP:0011146)1.93225146
86Muscle fiber atrophy (HP:0100295)1.92001867
87Genital tract atresia (HP:0001827)1.91269128
88Selective tooth agenesis (HP:0001592)1.90711465
89Epileptic encephalopathy (HP:0200134)1.89601544
90Exertional dyspnea (HP:0002875)1.88586031
91Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.88530767
92Absent epiphyses (HP:0010577)1.88530767
93Abnormality of placental membranes (HP:0011409)1.87893703
94Abnormality of cells of the erythroid lineage (HP:0012130)1.87293969
95Increased muscle lipid content (HP:0009058)1.87113923
96Oral leukoplakia (HP:0002745)1.86760132
97Autoamputation (HP:0001218)1.85796433
98Patellar aplasia (HP:0006443)1.85358437
99Abnormal hair whorl (HP:0010721)1.84358973
100Abnormality of lateral ventricle (HP:0030047)1.84154565
101X-linked dominant inheritance (HP:0001423)1.83693179
102Squamous cell carcinoma (HP:0002860)1.83068437
103Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82633865
104Methylmalonic aciduria (HP:0012120)1.82047154
105Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81618537
106Hypothermia (HP:0002045)1.80238753
107Abnormality of alanine metabolism (HP:0010916)1.79576879
108Hyperalaninemia (HP:0003348)1.79576879
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79576879
110Broad distal phalanx of finger (HP:0009836)1.79346688
111Gout (HP:0001997)1.78971489
112Aplasia/Hypoplasia of the patella (HP:0006498)1.78591696
113Abnormality of methionine metabolism (HP:0010901)1.78416397
114Hyperglycinuria (HP:0003108)1.78275267
115Poor coordination (HP:0002370)1.77563498
116Microglossia (HP:0000171)1.77049922
117Microvesicular hepatic steatosis (HP:0001414)1.76723596
118Horseshoe kidney (HP:0000085)1.74769567
119Neoplasm of the peripheral nervous system (HP:0100007)1.74643979
120Death in infancy (HP:0001522)1.74497188
121Absent thumb (HP:0009777)1.74111579
122Fasciculations (HP:0002380)1.73978280
123Aplasia/Hypoplasia of the uvula (HP:0010293)1.73561179
124Abnormal number of incisors (HP:0011064)1.72229771
125Morphological abnormality of the inner ear (HP:0011390)1.71730593
126Dysautonomia (HP:0002459)1.71419053
127Focal seizures (HP:0007359)1.69398785
128Abnormal pupillary function (HP:0007686)1.69136185
129Hypoplastic pelvis (HP:0008839)1.68848490
130Abnormal number of erythroid precursors (HP:0012131)1.67930938
131Congenital ichthyosiform erythroderma (HP:0007431)1.67467102
132Lethargy (HP:0001254)1.67402169
133Abnormality of the umbilical cord (HP:0010881)1.66998001
134Aplasia/hypoplasia of the uterus (HP:0008684)1.66596948
135Progressive external ophthalmoplegia (HP:0000590)1.66161917
136Abnormality of aromatic amino acid family metabolism (HP:0004338)1.65315147
137Premature ovarian failure (HP:0008209)1.64687751
138Trismus (HP:0000211)1.63822092
139Cholecystitis (HP:0001082)1.62571819
140Abnormal gallbladder physiology (HP:0012438)1.62571819
141Secondary amenorrhea (HP:0000869)1.62189073
142Aplasia/Hypoplasia involving the musculature (HP:0001460)1.61943000
143Irregular epiphyses (HP:0010582)1.60811091
144Hyperventilation (HP:0002883)1.58451957
145Blindness (HP:0000618)1.57267377
146Atrophy/Degeneration involving motor neurons (HP:0007373)1.57102076
147Tongue fasciculations (HP:0001308)1.56987935
148Orthostatic hypotension (HP:0001278)1.56381655
149Amniotic constriction ring (HP:0009775)1.55331083

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.15370492
2BUB14.34574368
3TSSK63.75671787
4MAP3K122.99628819
5EIF2AK12.93203938
6NME12.83754322
7STK162.76450778
8WEE12.61873333
9ARAF2.58927979
10PNCK2.53993711
11NEK12.52755393
12CASK2.19017144
13SCYL22.09070451
14PLK41.86621416
15PLK21.84451459
16BRAF1.82447868
17EIF2AK31.81199470
18SRPK11.80135178
19CDK191.73355600
20CCNB11.71478522
21PLK31.68136453
22AKT31.67127424
23TESK21.63545743
24MAP3K41.51964029
25LIMK11.49636233
26SMG11.46812205
27CDC71.45437328
28BCR1.41665922
29DAPK11.35160564
30MAP2K71.33601825
31VRK11.33221274
32MINK11.29776259
33MST41.24234889
34MAPKAPK31.18845295
35PBK1.17465492
36PDK41.16925045
37PDK31.16925045
38NTRK31.15713352
39TRIM281.14853779
40EPHA21.14033194
41BRSK11.09956723
42OXSR11.08959540
43AURKA1.08591580
44PLK11.06229283
45GRK51.05907418
46KDR1.05038707
47SIK31.03544373
48IRAK31.01157643
49MARK10.98788850
50ATR0.98739771
51NME20.94921737
52MYLK0.92846243
53CDK70.92615122
54LRRK20.92479624
55CDK180.92322939
56PIM20.91905784
57TESK10.89625437
58CDK140.87999666
59TTK0.86321202
60BRSK20.86294807
61MKNK10.85843707
62TAF10.85305255
63OBSCN0.84101249
64CDK150.83522079
65ALK0.83205296
66NUAK10.79569033
67PRKCG0.79060019
68ABL20.77591001
69MAP2K40.77063623
70MAP3K110.76877703
71KSR10.76695190
72MST1R0.75942880
73CDK11A0.75916595
74MAP3K90.75097137
75SIK10.70717743
76UHMK10.70645716
77PAK10.70457193
78EPHA40.69085324
79PDK20.68796922
80PRKCI0.67774566
81CAMK2B0.65341840
82DYRK20.64734310
83EIF2AK20.64377470
84MAPK130.62428106
85CSNK1G10.61934647
86CSNK2A20.56508085
87STK40.56445095
88ZAK0.56334076
89CSNK1A1L0.55691313
90STK38L0.54946594
91CSNK1G30.54897359
92MAP3K80.54680606
93CSNK2A10.53946395
94LATS20.53836422
95CAMK2G0.53720187
96DAPK30.53607678
97STK100.52075989
98ADRBK10.51889459
99AKT20.50379762
100CSNK1G20.50162160
101PAK40.48937218
102PRPF4B0.47543365
103CSNK1E0.46491362
104PTK20.46039935
105ROCK20.45519906
106TLK10.45489545
107ERBB30.45195224
108GRK70.44860526
109AURKB0.44020123
110CDK10.43265529
111BMPR20.42938962
112CAMK2A0.41247583
113ILK0.40892529
114ADRBK20.40276110
115NTRK10.40082918
116CDK20.40073768
117MKNK20.39570712
118CAMK2D0.39525736
119RPS6KB20.39415866
120CHEK20.39302731
121RAF10.38507216
122PAK60.37284581
123CDK80.37283104
124ATM0.37269209
125BCKDK0.37221735
126CHEK10.36731408
127ERBB40.36625922
128WNK30.36149340
129PASK0.35300696
130CLK10.34840770
131PRKD30.33538683
132MAP4K20.32473570
133TAOK20.31156251
134MUSK0.28276097
135NEK60.27048977
136CDK40.26526069
137MAP2K20.25092498

Predicted pathways (KEGG)

RankGene SetZ-score
1* Proteasome_Homo sapiens_hsa030505.38151888
2Oxidative phosphorylation_Homo sapiens_hsa001904.45356496
3Parkinsons disease_Homo sapiens_hsa050123.80514711
4RNA polymerase_Homo sapiens_hsa030203.37773484
5Huntingtons disease_Homo sapiens_hsa050162.84506447
6Ribosome_Homo sapiens_hsa030102.77072225
7Alzheimers disease_Homo sapiens_hsa050102.62094664
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.60580575
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54082141
10Collecting duct acid secretion_Homo sapiens_hsa049662.53196004
11DNA replication_Homo sapiens_hsa030302.24508298
12Spliceosome_Homo sapiens_hsa030402.20875273
13Synaptic vesicle cycle_Homo sapiens_hsa047212.19233904
14Mismatch repair_Homo sapiens_hsa034302.11908472
15RNA transport_Homo sapiens_hsa030132.06787537
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89900310
17Pyrimidine metabolism_Homo sapiens_hsa002401.89292413
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.83072032
19Cardiac muscle contraction_Homo sapiens_hsa042601.74102767
20Nucleotide excision repair_Homo sapiens_hsa034201.72789923
21Nicotine addiction_Homo sapiens_hsa050331.65060663
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59815498
23Vibrio cholerae infection_Homo sapiens_hsa051101.59774409
24Protein export_Homo sapiens_hsa030601.59620110
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43908062
26Homologous recombination_Homo sapiens_hsa034401.31629246
27Purine metabolism_Homo sapiens_hsa002301.28786613
28Base excision repair_Homo sapiens_hsa034101.26761019
29Basal transcription factors_Homo sapiens_hsa030221.25226472
30Pyruvate metabolism_Homo sapiens_hsa006201.24725102
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.23403308
32Carbon metabolism_Homo sapiens_hsa012001.10097051
33Biosynthesis of amino acids_Homo sapiens_hsa012301.07222433
34Cell cycle_Homo sapiens_hsa041100.99933824
35RNA degradation_Homo sapiens_hsa030180.99623860
36Fructose and mannose metabolism_Homo sapiens_hsa000510.96400256
37Oocyte meiosis_Homo sapiens_hsa041140.95802126
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94219905
39N-Glycan biosynthesis_Homo sapiens_hsa005100.94168390
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94159065
41Vitamin B6 metabolism_Homo sapiens_hsa007500.87468125
42Regulation of autophagy_Homo sapiens_hsa041400.82912589
43Amphetamine addiction_Homo sapiens_hsa050310.79686578
44Propanoate metabolism_Homo sapiens_hsa006400.79161593
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75976981
46* Epstein-Barr virus infection_Homo sapiens_hsa051690.75830805
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75451354
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75080486
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74312331
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73858020
51Non-homologous end-joining_Homo sapiens_hsa034500.71754310
52GABAergic synapse_Homo sapiens_hsa047270.69742068
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68306678
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67389621
55Phototransduction_Homo sapiens_hsa047440.66842623
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66741155
57Fanconi anemia pathway_Homo sapiens_hsa034600.66390765
58Metabolic pathways_Homo sapiens_hsa011000.66210807
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65819745
60mRNA surveillance pathway_Homo sapiens_hsa030150.65357442
61Fatty acid elongation_Homo sapiens_hsa000620.65312830
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64848519
63Steroid biosynthesis_Homo sapiens_hsa001000.64702236
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64109803
65Dopaminergic synapse_Homo sapiens_hsa047280.63428146
66One carbon pool by folate_Homo sapiens_hsa006700.63257679
67Olfactory transduction_Homo sapiens_hsa047400.62011303
68Taste transduction_Homo sapiens_hsa047420.58147686
69Phenylalanine metabolism_Homo sapiens_hsa003600.57699613
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57622056
71Serotonergic synapse_Homo sapiens_hsa047260.55244704
72Tyrosine metabolism_Homo sapiens_hsa003500.55048737
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52421793
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51165566
75Pentose phosphate pathway_Homo sapiens_hsa000300.51006482
76Phagosome_Homo sapiens_hsa041450.49949108
77Peroxisome_Homo sapiens_hsa041460.49536456
78Sulfur relay system_Homo sapiens_hsa041220.48875282
79Long-term potentiation_Homo sapiens_hsa047200.48802597
80p53 signaling pathway_Homo sapiens_hsa041150.44108653
81Glutathione metabolism_Homo sapiens_hsa004800.43767870
82Rheumatoid arthritis_Homo sapiens_hsa053230.43715053
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42834519
84Fatty acid metabolism_Homo sapiens_hsa012120.42386069
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42190715
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.42144081
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41832879
88Morphine addiction_Homo sapiens_hsa050320.38615147
89Folate biosynthesis_Homo sapiens_hsa007900.38527308
90Circadian entrainment_Homo sapiens_hsa047130.37661305
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36575281
92Selenocompound metabolism_Homo sapiens_hsa004500.36494958
93Alcoholism_Homo sapiens_hsa050340.36454429
94beta-Alanine metabolism_Homo sapiens_hsa004100.34497070
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33384805
96Long-term depression_Homo sapiens_hsa047300.33249452
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32195897
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30256119
99Arginine and proline metabolism_Homo sapiens_hsa003300.28940463
100Cocaine addiction_Homo sapiens_hsa050300.28329973
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25961724
102Glutamatergic synapse_Homo sapiens_hsa047240.25695141
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23443702
104Shigellosis_Homo sapiens_hsa051310.22483768
105Type I diabetes mellitus_Homo sapiens_hsa049400.20946925
106Galactose metabolism_Homo sapiens_hsa000520.20079989
107Gap junction_Homo sapiens_hsa045400.18986493
108Calcium signaling pathway_Homo sapiens_hsa040200.18154704
109Insulin secretion_Homo sapiens_hsa049110.18105079
110Fatty acid degradation_Homo sapiens_hsa000710.17159243
111Arginine biosynthesis_Homo sapiens_hsa002200.16699603
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.14730921
113Sulfur metabolism_Homo sapiens_hsa009200.14540995
114Ether lipid metabolism_Homo sapiens_hsa005650.14454011
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.13903808
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.13277589
117Hedgehog signaling pathway_Homo sapiens_hsa043400.13163797
118Tryptophan metabolism_Homo sapiens_hsa003800.12900866
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12134957
120Lysine degradation_Homo sapiens_hsa003100.10173858
121Thyroid cancer_Homo sapiens_hsa052160.09160948
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.08694497
123Hippo signaling pathway_Homo sapiens_hsa043900.06831050
124Butanoate metabolism_Homo sapiens_hsa006500.01541601
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.01297815
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.00629080
127HTLV-I infection_Homo sapiens_hsa05166-0.0144588

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