PSMC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.61453248
2proteasome assembly (GO:0043248)5.39146122
3ATP synthesis coupled proton transport (GO:0015986)5.08782507
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.08782507
5* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)5.00051782
6cullin deneddylation (GO:0010388)4.85626389
7* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.78809668
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.78622019
9* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.64618919
10formation of translation preinitiation complex (GO:0001731)4.60954191
11* regulation of cellular amino acid metabolic process (GO:0006521)4.56441647
12* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.56224534
13* negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.54939204
14* negative regulation of ligase activity (GO:0051352)4.54939204
15protein neddylation (GO:0045116)4.48815247
16protein deneddylation (GO:0000338)4.38911275
17* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.34078915
18purine nucleobase biosynthetic process (GO:0009113)4.31461804
19maturation of SSU-rRNA (GO:0030490)4.26726446
20* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.25657731
21* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.25657731
22* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.20749423
23* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.20749423
24* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.20749423
25* signal transduction involved in DNA integrity checkpoint (GO:0072401)4.15208940
26* signal transduction involved in DNA damage checkpoint (GO:0072422)4.15208940
27ribosomal large subunit biogenesis (GO:0042273)4.14580467
28* positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.14505170
29* signal transduction involved in cell cycle checkpoint (GO:0072395)4.12300701
30nucleobase biosynthetic process (GO:0046112)4.09012469
31DNA double-strand break processing (GO:0000729)4.03479457
32CENP-A containing nucleosome assembly (GO:0034080)3.95758157
33* positive regulation of ligase activity (GO:0051351)3.95664498
34* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.88905886
35ribosome assembly (GO:0042255)3.82324578
36ribosomal small subunit biogenesis (GO:0042274)3.81280495
37chaperone-mediated protein transport (GO:0072321)3.80821250
387-methylguanosine mRNA capping (GO:0006370)3.77836283
39regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.76549084
40regulation of mitotic spindle checkpoint (GO:1903504)3.76549084
41chromatin remodeling at centromere (GO:0031055)3.76029575
42establishment of integrated proviral latency (GO:0075713)3.74018843
437-methylguanosine RNA capping (GO:0009452)3.71431147
44RNA capping (GO:0036260)3.71431147
45mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.66468553
46* regulation of ubiquitin-protein transferase activity (GO:0051438)3.64787406
47viral mRNA export from host cell nucleus (GO:0046784)3.63865176
48termination of RNA polymerase III transcription (GO:0006386)3.60788516
49transcription elongation from RNA polymerase III promoter (GO:0006385)3.60788516
50DNA strand elongation involved in DNA replication (GO:0006271)3.59937645
51* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.55789435
52organelle disassembly (GO:1903008)3.54833016
53ribonucleoprotein complex biogenesis (GO:0022613)3.54586863
54translational termination (GO:0006415)3.53677404
55* regulation of ligase activity (GO:0051340)3.51185206
56L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.50273466
57* G1/S transition of mitotic cell cycle (GO:0000082)3.49663042
58* cell cycle G1/S phase transition (GO:0044843)3.49663042
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.49076351
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.48794544
61viral transcription (GO:0019083)3.46701600
62transcription elongation from RNA polymerase I promoter (GO:0006362)3.45557992
63DNA replication initiation (GO:0006270)3.44728149
64DNA damage response, detection of DNA damage (GO:0042769)3.44159197
65DNA strand elongation (GO:0022616)3.43782278
66* positive regulation of cell cycle arrest (GO:0071158)3.43306241
67* regulation of cellular amine metabolic process (GO:0033238)3.43277038
68replication fork processing (GO:0031297)3.42140376
69translational initiation (GO:0006413)3.40386233
70respiratory electron transport chain (GO:0022904)3.40025900
71telomere maintenance via semi-conservative replication (GO:0032201)3.39282407
72DNA ligation (GO:0006266)3.39239358
73establishment of protein localization to mitochondrion (GO:0072655)3.38933536
74translation (GO:0006412)3.37438605
75spliceosomal snRNP assembly (GO:0000387)3.37226337
76ribosomal small subunit assembly (GO:0000028)3.35744829
77rRNA processing (GO:0006364)3.32443836
78regulation of mitochondrial translation (GO:0070129)3.32102000
79DNA replication-independent nucleosome organization (GO:0034724)3.31533381
80DNA replication-independent nucleosome assembly (GO:0006336)3.31533381
81electron transport chain (GO:0022900)3.30973588
82* DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.30252889
83transcription-coupled nucleotide-excision repair (GO:0006283)3.30248387
84ribonucleoprotein complex disassembly (GO:0032988)3.29636154
85termination of RNA polymerase I transcription (GO:0006363)3.29238944
86DNA unwinding involved in DNA replication (GO:0006268)3.28476119
87protein targeting to mitochondrion (GO:0006626)3.27495730
88DNA replication checkpoint (GO:0000076)3.27311221
89ribosome biogenesis (GO:0042254)3.25749765
90mitotic metaphase plate congression (GO:0007080)3.25727020
91oxidative phosphorylation (GO:0006119)3.25616903
92kinetochore organization (GO:0051383)3.23784284
93mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23395994
94mitochondrial respiratory chain complex I assembly (GO:0032981)3.23395994
95NADH dehydrogenase complex assembly (GO:0010257)3.23395994
96cellular component biogenesis (GO:0044085)3.23161479
97metaphase plate congression (GO:0051310)3.23110093
98de novo protein folding (GO:0006458)3.22655581
99maturation of 5.8S rRNA (GO:0000460)3.22166158
100rRNA modification (GO:0000154)3.21437113
101respiratory chain complex IV assembly (GO:0008535)3.20163359
102protein localization to mitochondrion (GO:0070585)3.18979252
103cotranslational protein targeting to membrane (GO:0006613)3.18813793
104double-strand break repair via nonhomologous end joining (GO:0006303)3.17991832
105non-recombinational repair (GO:0000726)3.17991832
106rRNA metabolic process (GO:0016072)3.17805209
107translational elongation (GO:0006414)3.16848100
108guanosine-containing compound biosynthetic process (GO:1901070)3.16604478
109histone exchange (GO:0043486)3.16323110
110RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.15859889
111tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.15859889
112telomere maintenance via recombination (GO:0000722)3.15270000
113SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.14678833
114negative regulation of DNA-dependent DNA replication (GO:2000104)3.13858890
115DNA replication-dependent nucleosome assembly (GO:0006335)3.12733600
116mitochondrial respiratory chain complex assembly (GO:0033108)3.11802143
117protein complex biogenesis (GO:0070271)3.09979113
118regulation of helicase activity (GO:0051095)3.09184711
119protein localization to kinetochore (GO:0034501)3.08118048
120DNA catabolic process, exonucleolytic (GO:0000738)3.06120711
121histone mRNA metabolic process (GO:0008334)3.04228756
122establishment of viral latency (GO:0019043)3.00554791
123regulation of centriole replication (GO:0046599)2.95751959
124spindle checkpoint (GO:0031577)2.94478228
125kinetochore assembly (GO:0051382)2.93395230
126protein K11-linked ubiquitination (GO:0070979)2.90493713
127protein-cofactor linkage (GO:0018065)2.89266145
128DNA replication-dependent nucleosome organization (GO:0034723)2.89067959
129mitotic spindle checkpoint (GO:0071174)2.86353737
130mitochondrial RNA metabolic process (GO:0000959)2.85146057
131somatic hypermutation of immunoglobulin genes (GO:0016446)2.84522185
132somatic diversification of immune receptors via somatic mutation (GO:0002566)2.84522185
133negative regulation of DNA recombination (GO:0045910)2.84414750
134protein K6-linked ubiquitination (GO:0085020)2.84003045
135RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.81988363
136postreplication repair (GO:0006301)2.80884308
137negative regulation of mitotic sister chromatid separation (GO:2000816)2.78309635
138negative regulation of sister chromatid segregation (GO:0033046)2.78309635
139negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.78309635
140negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.78309635
141negative regulation of mitotic sister chromatid segregation (GO:0033048)2.78309635

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.87440919
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.75085039
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.47994593
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.30098890
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.14719728
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.77929029
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.68435639
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.67128202
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.55276309
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42537960
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.28274123
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.07350496
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.02985028
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.98078407
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.97974465
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.97938725
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.96226483
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93704367
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.82180664
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.76738482
21ELK1_19687146_ChIP-ChIP_HELA_Human2.59640186
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.56519492
23* VDR_23849224_ChIP-Seq_CD4+_Human2.52746299
24DCP1A_22483619_ChIP-Seq_HELA_Human2.41591465
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.39785564
26XRN2_22483619_ChIP-Seq_HELA_Human2.34529455
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29730452
28ZNF274_21170338_ChIP-Seq_K562_Hela2.29296901
29THAP11_20581084_ChIP-Seq_MESCs_Mouse2.28032358
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23905394
31VDR_22108803_ChIP-Seq_LS180_Human2.18966434
32RBPJ_22232070_ChIP-Seq_NCS_Mouse2.18869113
33* AR_21909140_ChIP-Seq_LNCAP_Human2.11616769
34FOXP3_21729870_ChIP-Seq_TREG_Human2.09881690
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.07280821
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06180512
37SRF_21415370_ChIP-Seq_HL-1_Mouse2.05071179
38TTF2_22483619_ChIP-Seq_HELA_Human2.03430231
39* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00189804
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.99615464
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96835571
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.94692126
43IGF1R_20145208_ChIP-Seq_DFB_Human1.94494185
44GABP_19822575_ChIP-Seq_HepG2_Human1.91755840
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90426936
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88874875
47* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88530047
48TAF15_26573619_Chip-Seq_HEK293_Human1.84169883
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81946575
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79947667
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.78655490
52* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76489547
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75183442
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.71564775
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69413484
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.68100773
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61951895
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59206977
59* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51388773
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.50486732
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.48319116
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46971909
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46471411
64P300_19829295_ChIP-Seq_ESCs_Human1.41843610
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32382720
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.30853690
67SOX17_20123909_ChIP-Seq_XEN_Mouse1.29170780
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.28163516
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.28069658
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23527880
71MYC_18940864_ChIP-ChIP_HL60_Human1.23160241
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22909630
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20713843
74CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.20098329
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19256304
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18196771
77FUS_26573619_Chip-Seq_HEK293_Human1.17466143
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16992535
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15377710
80KDM5A_27292631_Chip-Seq_BREAST_Human1.14561380
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.12421106
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09821072
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06399171
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05898840
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04057644
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03851118
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03408167
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01803312
89ER_23166858_ChIP-Seq_MCF-7_Human1.01261128
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01159121
91ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00309237
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99769321
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99341915
94EZH2_27294783_Chip-Seq_NPCs_Mouse0.99032470
95IRF1_19129219_ChIP-ChIP_H3396_Human0.98411607
96POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96275005
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94240649
98NANOG_16153702_ChIP-ChIP_HESCs_Human0.91799693
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91514930
100EWS_26573619_Chip-Seq_HEK293_Human0.91123346
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90635621
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90247320
103CBP_20019798_ChIP-Seq_JUKART_Human0.90247320
104STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89914677
105GBX2_23144817_ChIP-Seq_PC3_Human0.89177781
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88883085
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88678699
108* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88595056
109TFEB_21752829_ChIP-Seq_HELA_Human0.88454771
110TP53_22573176_ChIP-Seq_HFKS_Human0.88294511
111NFE2_27457419_Chip-Seq_LIVER_Mouse0.87912972
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87522955
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86117465
114SOX2_19829295_ChIP-Seq_ESCs_Human0.84879874
115NANOG_19829295_ChIP-Seq_ESCs_Human0.84879874
116NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83996008
117PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83714353
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83549806
119NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82347631
120SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81970463
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81871592
122KLF4_18555785_ChIP-Seq_MESCs_Mouse0.81747381
123SOX2_16153702_ChIP-ChIP_HESCs_Human0.81459044
124OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78965320
125CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.78673904
126TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76495330
127CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.75510124
128FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.72933065
129CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.72013383
130PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.71439038
131TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.71422155
132CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.70334734
133NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.69819073
134CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69728690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog4.56183138
2MP0003693_abnormal_embryo_hatching4.41824191
3MP0003806_abnormal_nucleotide_metabolis3.73655421
4MP0008057_abnormal_DNA_replication3.47988746
5MP0010094_abnormal_chromosome_stability3.43668024
6MP0008932_abnormal_embryonic_tissue3.27844402
7MP0003077_abnormal_cell_cycle3.18915199
8MP0003111_abnormal_nucleus_morphology3.01387442
9MP0008058_abnormal_DNA_repair2.84211366
10MP0001529_abnormal_vocalization2.83048428
11MP0003718_maternal_effect2.63372813
12MP0009379_abnormal_foot_pigmentation2.51013584
13MP0003123_paternal_imprinting2.34174559
14MP0001730_embryonic_growth_arrest2.10772846
15MP0003786_premature_aging2.03928777
16MP0008007_abnormal_cellular_replicative2.01187346
17MP0006035_abnormal_mitochondrial_morpho1.99118636
18MP0009697_abnormal_copulation1.91520879
19MP0003315_abnormal_perineum_morphology1.87453784
20MP0006036_abnormal_mitochondrial_physio1.87420658
21MP0004147_increased_porphyrin_level1.75759152
22MP0001905_abnormal_dopamine_level1.74280263
23MP0010030_abnormal_orbit_morphology1.73014250
24MP0003186_abnormal_redox_activity1.69401452
25MP0003221_abnormal_cardiomyocyte_apopto1.67681928
26MP0003567_abnormal_fetal_cardiomyocyte1.66708516
27MP0008260_abnormal_autophagy1.66655181
28MP0005253_abnormal_eye_physiology1.64747057
29MP0003941_abnormal_skin_development1.64653225
30MP0000350_abnormal_cell_proliferation1.62885170
31MP0008877_abnormal_DNA_methylation1.55337767
32MP0008995_early_reproductive_senescence1.54958181
33MP0006276_abnormal_autonomic_nervous1.52401170
34MP0002102_abnormal_ear_morphology1.50180605
35MP0005084_abnormal_gallbladder_morpholo1.47566292
36MP0001697_abnormal_embryo_size1.44705388
37MP0008789_abnormal_olfactory_epithelium1.43872566
38MP0003121_genomic_imprinting1.38725257
39MP0001984_abnormal_olfaction1.38443905
40MP0000647_abnormal_sebaceous_gland1.36622491
41MP0000537_abnormal_urethra_morphology1.35574230
42MP0003890_abnormal_embryonic-extraembry1.35532672
43MP0002751_abnormal_autonomic_nervous1.31744065
44MP0003011_delayed_dark_adaptation1.30466018
45MP0005367_renal/urinary_system_phenotyp1.28365181
46MP0000516_abnormal_urinary_system1.28365181
47MP0003195_calcinosis1.28287818
48MP0002736_abnormal_nociception_after1.25676701
49MP0005408_hypopigmentation1.24737556
50MP0002080_prenatal_lethality1.23113860
51MP0003937_abnormal_limbs/digits/tail_de1.22748921
52MP0002938_white_spotting1.21774787
53MP0002234_abnormal_pharynx_morphology1.20359934
54MP0005380_embryogenesis_phenotype1.19787646
55MP0001672_abnormal_embryogenesis/_devel1.19787646
56MP0003950_abnormal_plasma_membrane1.19045214
57MP0000372_irregular_coat_pigmentation1.18054386
58MP0001542_abnormal_bone_strength1.16320180
59MP0009053_abnormal_anal_canal1.14565493
60MP0001727_abnormal_embryo_implantation1.10812316
61MP0005551_abnormal_eye_electrophysiolog1.10012717
62MP0002160_abnormal_reproductive_system1.08947919
63MP0000358_abnormal_cell_content/1.08893779
64MP0002090_abnormal_vision1.07972477
65MP0003984_embryonic_growth_retardation1.06860925
66MP0002085_abnormal_embryonic_tissue1.06490944
67MP0002088_abnormal_embryonic_growth/wei1.03591354
68MP0003119_abnormal_digestive_system1.03388989
69MP0000427_abnormal_hair_cycle1.02949973
70MP0001929_abnormal_gametogenesis1.02567279
71MP0005391_vision/eye_phenotype1.00503491
72MP0005187_abnormal_penis_morphology0.99855525
73MP0005389_reproductive_system_phenotype0.99491832
74MP0004084_abnormal_cardiac_muscle0.99423755
75MP0006072_abnormal_retinal_apoptosis0.98546697
76MP0002084_abnormal_developmental_patter0.97637469
77MP0004215_abnormal_myocardial_fiber0.97564802
78MP0005266_abnormal_metabolism0.92500528
79MP0000749_muscle_degeneration0.90433938
80MP0001177_atelectasis0.90079460
81MP0004197_abnormal_fetal_growth/weight/0.88787159
82MP0000569_abnormal_digit_pigmentation0.87426441
83MP0000762_abnormal_tongue_morphology0.86470242
84MP0005171_absent_coat_pigmentation0.85748770
85MP0002210_abnormal_sex_determination0.85384144
86MP0009046_muscle_twitch0.84969839
87MP0004134_abnormal_chest_morphology0.84031017
88MP0000313_abnormal_cell_death0.83545680
89MP0000750_abnormal_muscle_regeneration0.83527691
90MP0003880_abnormal_central_pattern0.83441142
91MP0002282_abnormal_trachea_morphology0.82163511
92MP0002837_dystrophic_cardiac_calcinosis0.81404602
93MP0002111_abnormal_tail_morphology0.81273274
94MP0008872_abnormal_physiological_respon0.80836951
95MP0000631_abnormal_neuroendocrine_gland0.80499092
96MP0004133_heterotaxia0.79982721
97MP0001188_hyperpigmentation0.79912553
98MP0003122_maternal_imprinting0.78194805
99MP0006292_abnormal_olfactory_placode0.77140223
100MP0005248_abnormal_Harderian_gland0.77085692
101MP0001293_anophthalmia0.77039297
102MP0001485_abnormal_pinna_reflex0.76500980
103MP0000383_abnormal_hair_follicle0.76498380
104MP0001919_abnormal_reproductive_system0.76138706
105MP0000049_abnormal_middle_ear0.75913240
106MP0006054_spinal_hemorrhage0.75764441
107MP0010307_abnormal_tumor_latency0.75036266
108MP0001145_abnormal_male_reproductive0.73849416
109MP0005395_other_phenotype0.73751626
110MP0001119_abnormal_female_reproductive0.72910595
111MP0003755_abnormal_palate_morphology0.72355208
112MP0005394_taste/olfaction_phenotype0.72334683
113MP0005499_abnormal_olfactory_system0.72334683
114MP0009250_abnormal_appendicular_skeleto0.72096555
115MP0002697_abnormal_eye_size0.71449441
116MP0003656_abnormal_erythrocyte_physiolo0.70217041
117MP0003698_abnormal_male_reproductive0.69894760
118MP0002127_abnormal_cardiovascular_syste0.69350644
119MP0002638_abnormal_pupillary_reflex0.69210536
120MP0003136_yellow_coat_color0.69161182
121MP0003938_abnormal_ear_development0.69006505
122MP0001286_abnormal_eye_development0.65544352
123MP0004036_abnormal_muscle_relaxation0.64628523
124MP0002086_abnormal_extraembryonic_tissu0.62769602
125MP0000653_abnormal_sex_gland0.61033089
126MP0005330_cardiomyopathy0.60961746
127MP0003861_abnormal_nervous_system0.60161570
128MP0001299_abnormal_eye_distance/0.59467960
129MP0004142_abnormal_muscle_tone0.59098901
130MP0002233_abnormal_nose_morphology0.59067417
131MP0001764_abnormal_homeostasis0.58711894

Predicted human phenotypes

RankGene SetZ-score
1Increased serum pyruvate (HP:0003542)5.76780056
2Abnormality of glycolysis (HP:0004366)5.76780056
3Acute necrotizing encephalopathy (HP:0006965)5.43395129
4Abnormal mitochondria in muscle tissue (HP:0008316)4.81683862
5Mitochondrial inheritance (HP:0001427)4.53167795
6Progressive macrocephaly (HP:0004481)4.47079719
7Birth length less than 3rd percentile (HP:0003561)4.36824636
8Acute encephalopathy (HP:0006846)4.32305854
9Increased CSF lactate (HP:0002490)4.27459196
10Increased hepatocellular lipid droplets (HP:0006565)3.97429991
11Hepatocellular necrosis (HP:0001404)3.82847796
12Breast hypoplasia (HP:0003187)3.73280719
13Cerebral hypomyelination (HP:0006808)3.60316445
14Lipid accumulation in hepatocytes (HP:0006561)3.54503520
15Cerebral edema (HP:0002181)3.33277642
16Hepatic necrosis (HP:0002605)3.31868649
17Increased serum lactate (HP:0002151)3.21922043
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.99344449
19Exercise intolerance (HP:0003546)2.98558563
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.97704408
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.96694814
22Abnormality of alanine metabolism (HP:0010916)2.96694814
23Hyperalaninemia (HP:0003348)2.96694814
24Colon cancer (HP:0003003)2.93650945
25Irregular epiphyses (HP:0010582)2.91241232
26Leukodystrophy (HP:0002415)2.89707795
27Meckel diverticulum (HP:0002245)2.85445485
28Macrocytic anemia (HP:0001972)2.84558424
29Respiratory failure (HP:0002878)2.80641115
30Renal Fanconi syndrome (HP:0001994)2.79495951
31Reticulocytopenia (HP:0001896)2.74259440
32Abnormality of the ileum (HP:0001549)2.73965287
33Lactic acidosis (HP:0003128)2.73870605
34Methylmalonic acidemia (HP:0002912)2.68989259
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.67664847
36Abnormality of cells of the erythroid lineage (HP:0012130)2.67218277
37Pancreatic cysts (HP:0001737)2.65888231
383-Methylglutaconic aciduria (HP:0003535)2.64545236
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.63849216
40Abnormality of chromosome stability (HP:0003220)2.61550765
41Carpal bone hypoplasia (HP:0001498)2.60762912
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.59694742
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.59694742
44Oral leukoplakia (HP:0002745)2.57021134
45Rough bone trabeculation (HP:0100670)2.46295862
46Abnormality of the labia minora (HP:0012880)2.45199603
47Pancreatic fibrosis (HP:0100732)2.42384753
48Abnormality of methionine metabolism (HP:0010901)2.42251136
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.40708636
50Optic disc pallor (HP:0000543)2.39666303
51Postnatal microcephaly (HP:0005484)2.37698523
52CNS hypomyelination (HP:0003429)2.36246358
53Increased intramyocellular lipid droplets (HP:0012240)2.36091176
54Abnormality of serum amino acid levels (HP:0003112)2.35657296
55Hyperglycinemia (HP:0002154)2.33644122
56Chromsome breakage (HP:0040012)2.33299634
57Rimmed vacuoles (HP:0003805)2.32684375
58CNS demyelination (HP:0007305)2.32454992
59True hermaphroditism (HP:0010459)2.31100406
60Respiratory difficulties (HP:0002880)2.30561560
61Medial flaring of the eyebrow (HP:0010747)2.28865956
62Parakeratosis (HP:0001036)2.28681894
63Abnormality of the preputium (HP:0100587)2.27188706
64Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26914602
65Type I transferrin isoform profile (HP:0003642)2.25312666
66Small intestinal stenosis (HP:0012848)2.25242379
67Duodenal stenosis (HP:0100867)2.25242379
68Volvulus (HP:0002580)2.24244125
69Abnormality of the anterior horn cell (HP:0006802)2.23321889
70Degeneration of anterior horn cells (HP:0002398)2.23321889
71Congenital, generalized hypertrichosis (HP:0004540)2.20412991
72Secondary amenorrhea (HP:0000869)2.18939985
73Congenital ichthyosiform erythroderma (HP:0007431)2.18111383
74Shoulder girdle muscle weakness (HP:0003547)2.16877766
75Stenosis of the external auditory canal (HP:0000402)2.15947417
76Abnormal number of erythroid precursors (HP:0012131)2.14498423
77Abnormality of midbrain morphology (HP:0002418)2.14194882
78Molar tooth sign on MRI (HP:0002419)2.14194882
79Patellar aplasia (HP:0006443)2.14159821
80Emotional lability (HP:0000712)2.12138677
81Methylmalonic aciduria (HP:0012120)2.12030959
82Glossoptosis (HP:0000162)2.11900901
83Pallor (HP:0000980)2.09484965
84Exertional dyspnea (HP:0002875)2.09110842
85Delusions (HP:0000746)2.07851293
86Intestinal atresia (HP:0011100)2.06410542
87Microvesicular hepatic steatosis (HP:0001414)2.04299564
88Aplasia/Hypoplasia of the patella (HP:0006498)2.04243238
89Abnormality of the duodenum (HP:0002246)2.04172283
90Amniotic constriction ring (HP:0009775)2.02835428
91Abnormality of placental membranes (HP:0011409)2.02835428
92Hypoplasia of the capital femoral epiphysis (HP:0003090)2.02537942
93Nemaline bodies (HP:0003798)2.02344017
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02120170
95Abnormal protein N-linked glycosylation (HP:0012347)2.02120170
96Abnormal protein glycosylation (HP:0012346)2.02120170
97Abnormal glycosylation (HP:0012345)2.02120170
98Autoamputation (HP:0001218)2.00248416
99Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.99775622
100Absent epiphyses (HP:0010577)1.99775622
101Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.98878505
102Abnormal trabecular bone morphology (HP:0100671)1.96863697
103Congenital primary aphakia (HP:0007707)1.96836504
104Absent radius (HP:0003974)1.96296757
105Supernumerary spleens (HP:0009799)1.94729072
106Ependymoma (HP:0002888)1.93760128
107Reduced antithrombin III activity (HP:0001976)1.91853122
108Hypoplastic pelvis (HP:0008839)1.91261381
109Horseshoe kidney (HP:0000085)1.90443435
110Medulloblastoma (HP:0002885)1.87310610
111Multiple enchondromatosis (HP:0005701)1.87228180
112Abnormal lung lobation (HP:0002101)1.85914248
113Gait imbalance (HP:0002141)1.85660631
114Short tibia (HP:0005736)1.84762193
115Lethargy (HP:0001254)1.83972531
116Nephronophthisis (HP:0000090)1.83283924
117Sloping forehead (HP:0000340)1.83202047
118Neoplasm of the colon (HP:0100273)1.82187218
119Aplasia/Hypoplasia of the tibia (HP:0005772)1.81811156
120Hypothermia (HP:0002045)1.81712375
121Increased muscle lipid content (HP:0009058)1.81540853
122Unsteady gait (HP:0002317)1.81290760
123Absent forearm bone (HP:0003953)1.81119362
124Aplasia involving forearm bones (HP:0009822)1.81119362
125Nephrogenic diabetes insipidus (HP:0009806)1.80674744
126X-linked dominant inheritance (HP:0001423)1.80082283
127Triphalangeal thumb (HP:0001199)1.79347590
128Abnormality of the umbilical cord (HP:0010881)1.78608418
129Abnormality of serine family amino acid metabolism (HP:0010894)1.78127043
130Abnormality of glycine metabolism (HP:0010895)1.78127043
131Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.76955252
132Aplasia/Hypoplasia involving the musculature (HP:0001460)1.76747258
133Genital tract atresia (HP:0001827)1.76597602
134Glioma (HP:0009733)1.76508501
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.73643304
136Abnormalities of placenta or umbilical cord (HP:0001194)1.72853726
137Selective tooth agenesis (HP:0001592)1.71590820
138Trismus (HP:0000211)1.71487933
139Premature graying of hair (HP:0002216)1.71424108
140Hyperglycinuria (HP:0003108)1.71393541
141Calcaneovalgus deformity (HP:0001848)1.71033497
142Abnormal autonomic nervous system physiology (HP:0012332)1.70624901
143Vaginal atresia (HP:0000148)1.70616624
144Megaloblastic anemia (HP:0001889)1.69847168
145Neoplasm of the adrenal gland (HP:0100631)1.69735589
146Muscle fiber inclusion bodies (HP:0100299)1.69641507
147Aplastic anemia (HP:0001915)1.68857744
148Renal cortical cysts (HP:0000803)1.66546992
149Gonadotropin excess (HP:0000837)1.66061695
150Impulsivity (HP:0100710)1.64170462
151Rhabdomyosarcoma (HP:0002859)1.64140834
152Adrenal hypoplasia (HP:0000835)1.63962262
153Sclerocornea (HP:0000647)1.63940525
154Cortical dysplasia (HP:0002539)1.63880274
155Abnormality of the pons (HP:0007361)1.63597944
156Abnormality of the fetal cardiovascular system (HP:0010948)1.63186140
157Single umbilical artery (HP:0001195)1.63186140
158Embryonal renal neoplasm (HP:0011794)1.61611961

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.31478459
2EIF2AK13.98878125
3WEE13.78412302
4PBK3.31274888
5STK163.10914639
6SRPK12.97180374
7TRIM282.96022107
8NEK12.77695500
9NME22.65417027
10TSSK62.61237419
11EIF2AK32.58880672
12CDC72.34008455
13PLK42.08321808
14PNCK2.06986942
15NME11.96406493
16MKNK11.92134910
17MST41.91861039
18PLK31.89967945
19LIMK11.87366447
20NUAK11.82261542
21BRSK21.80653640
22ACVR1B1.73042714
23VRK11.70414375
24VRK21.67290854
25FRK1.66177827
26BCR1.65023102
27MAP4K21.60371135
28TESK21.41049161
29CCNB11.39224168
30PLK11.38072012
31PLK21.33007307
32MAP3K121.28592301
33EPHA21.26139914
34DYRK21.26065131
35AURKA1.23716693
36TLK11.18486705
37AURKB1.16667440
38TTK1.13884018
39ZAK1.10730427
40TNIK1.10366987
41DYRK31.00834018
42TAF10.99737859
43PDK30.99138107
44PDK40.99138107
45MKNK20.95683929
46CSNK1G30.94313822
47BRSK10.93392559
48OBSCN0.92817658
49AKT30.91841867
50BRAF0.91438340
51RPS6KB20.89741065
52NEK20.88543394
53PDK20.84880999
54MAPK130.83109133
55ERBB30.78827604
56GRK10.77980862
57STK390.77548120
58PASK0.77341319
59CSNK2A20.76418810
60TESK10.76287824
61EIF2AK20.75037310
62PINK10.74901877
63CSNK2A10.73745883
64BCKDK0.69584498
65TGFBR10.69151549
66BMPR1B0.68599518
67STK38L0.68243037
68CHEK20.68152702
69ARAF0.66466315
70ATR0.66029378
71MYLK0.65713652
72CASK0.65422832
73CSNK1G10.65368084
74CDK190.63469236
75GRK70.61496663
76OXSR10.60767165
77ADRBK20.58360485
78SIK30.58235750
79CDK80.58066848
80CHEK10.57992663
81INSRR0.57878762
82CDK70.57595949
83PIM20.57335858
84MAP3K50.54984636
85YES10.54353708
86WNK30.54243328
87PAK10.53504470
88PRKCE0.52822003
89PAK40.52761045
90ABL20.50085482
91RPS6KA50.50002379
92MAP3K80.49456741
93CDK30.46945210
94MAP3K40.46565980
95CSNK1E0.46509139
96PAK30.46394174
97MARK10.45323471
98CDK140.44990246
99CSNK1G20.43855179
100CDK10.43730990
101PRKCG0.41932634
102CSNK1A1L0.41636946
103ADRBK10.40199524
104MUSK0.40147615
105MELK0.39883817
106ATM0.39425929
107BRD40.38882054
108STK30.38813847
109MAP2K70.37916932
110ERBB40.37585474
111CDK180.36166922
112CDK20.35333159
113WNK40.35224034
114SCYL20.34966135
115RPS6KA40.33129715
116EPHA40.33087819
117CSNK1A10.32915525
118PRKCI0.32571877
119CAMK2B0.32565328
120DYRK1A0.32406848
121CDK150.32270920
122ILK0.31653890
123CDK11A0.30361576
124FGFR10.29427314
125FER0.28009270
126LATS20.27790266
127MINK10.27696992
128PRKACB0.25627563
129STK40.25242998
130CAMK2A0.24577948
131MAP2K40.23347917
132PIK3CA0.20250590

Predicted pathways (KEGG)

RankGene SetZ-score
1* Proteasome_Homo sapiens_hsa030505.62873383
2Ribosome_Homo sapiens_hsa030103.62113860
3RNA polymerase_Homo sapiens_hsa030203.49892801
4Oxidative phosphorylation_Homo sapiens_hsa001903.30648690
5DNA replication_Homo sapiens_hsa030303.24369917
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.19712312
7Mismatch repair_Homo sapiens_hsa034303.05970019
8Parkinsons disease_Homo sapiens_hsa050122.96162250
9Spliceosome_Homo sapiens_hsa030402.71690158
10RNA transport_Homo sapiens_hsa030132.59525342
11Nucleotide excision repair_Homo sapiens_hsa034202.45789686
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.25337426
13Huntingtons disease_Homo sapiens_hsa050162.22805643
14Pyrimidine metabolism_Homo sapiens_hsa002402.19405423
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.18738436
16Protein export_Homo sapiens_hsa030602.07504948
17Homologous recombination_Homo sapiens_hsa034401.96063586
18Alzheimers disease_Homo sapiens_hsa050101.92038886
19Basal transcription factors_Homo sapiens_hsa030221.78907706
20Cell cycle_Homo sapiens_hsa041101.74347470
21One carbon pool by folate_Homo sapiens_hsa006701.70523791
22Base excision repair_Homo sapiens_hsa034101.66273309
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56881069
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51775945
25RNA degradation_Homo sapiens_hsa030181.48482104
26Non-homologous end-joining_Homo sapiens_hsa034501.47359370
27Vitamin B6 metabolism_Homo sapiens_hsa007501.33975314
28Steroid biosynthesis_Homo sapiens_hsa001001.32057923
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30793102
30Purine metabolism_Homo sapiens_hsa002301.29233297
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25290996
32Fanconi anemia pathway_Homo sapiens_hsa034601.15467390
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.04028824
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03971678
35Fatty acid elongation_Homo sapiens_hsa000621.01171057
36Glutathione metabolism_Homo sapiens_hsa004800.97610561
37Carbon metabolism_Homo sapiens_hsa012000.97262791
38* Epstein-Barr virus infection_Homo sapiens_hsa051690.95159085
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94686227
40Pyruvate metabolism_Homo sapiens_hsa006200.94603779
41mRNA surveillance pathway_Homo sapiens_hsa030150.92926568
42Cardiac muscle contraction_Homo sapiens_hsa042600.92799553
43Systemic lupus erythematosus_Homo sapiens_hsa053220.90808078
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85725739
45Biosynthesis of amino acids_Homo sapiens_hsa012300.84775248
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83614445
47Collecting duct acid secretion_Homo sapiens_hsa049660.83581109
48Folate biosynthesis_Homo sapiens_hsa007900.83074143
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80878697
50Oocyte meiosis_Homo sapiens_hsa041140.78387295
51p53 signaling pathway_Homo sapiens_hsa041150.76009144
52Tryptophan metabolism_Homo sapiens_hsa003800.73137876
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71621642
54Metabolic pathways_Homo sapiens_hsa011000.68497661
55Regulation of autophagy_Homo sapiens_hsa041400.67728477
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.67722716
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.67175516
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66916917
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66900148
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65028976
61Tyrosine metabolism_Homo sapiens_hsa003500.63890350
62Propanoate metabolism_Homo sapiens_hsa006400.63641764
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61504096
64Pentose phosphate pathway_Homo sapiens_hsa000300.60960734
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60587564
66Fatty acid metabolism_Homo sapiens_hsa012120.60550718
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.59575630
68Vibrio cholerae infection_Homo sapiens_hsa051100.58995781
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58502500
70Nitrogen metabolism_Homo sapiens_hsa009100.57329493
71Fatty acid degradation_Homo sapiens_hsa000710.55891658
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55603173
73Phenylalanine metabolism_Homo sapiens_hsa003600.52706368
74Caffeine metabolism_Homo sapiens_hsa002320.50093992
75Arginine and proline metabolism_Homo sapiens_hsa003300.44521584
76N-Glycan biosynthesis_Homo sapiens_hsa005100.42675271
77Fructose and mannose metabolism_Homo sapiens_hsa000510.42230407
78Circadian rhythm_Homo sapiens_hsa047100.41473511
79Sulfur metabolism_Homo sapiens_hsa009200.40891034
80Alcoholism_Homo sapiens_hsa050340.40859264
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40343784
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39324861
83Arachidonic acid metabolism_Homo sapiens_hsa005900.37078963
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37005395
85Sulfur relay system_Homo sapiens_hsa041220.37004490
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35226465
87Butanoate metabolism_Homo sapiens_hsa006500.34457540
88Selenocompound metabolism_Homo sapiens_hsa004500.34400342
89Viral carcinogenesis_Homo sapiens_hsa052030.33729544
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.31620012
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.30839112
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30557261
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30377203
94Phagosome_Homo sapiens_hsa041450.30278515
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29367590
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25385313
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24694331
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23268067
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21565572
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21195206
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21136006
102Taste transduction_Homo sapiens_hsa047420.20513697
103Nicotine addiction_Homo sapiens_hsa050330.20410406
104Peroxisome_Homo sapiens_hsa041460.17426998
105Chemical carcinogenesis_Homo sapiens_hsa052040.15740487
106Rheumatoid arthritis_Homo sapiens_hsa053230.15510973
107Ether lipid metabolism_Homo sapiens_hsa005650.15506878
108Legionellosis_Homo sapiens_hsa051340.14701615
109Linoleic acid metabolism_Homo sapiens_hsa005910.12844805
110Retinol metabolism_Homo sapiens_hsa008300.12336946
111Antigen processing and presentation_Homo sapiens_hsa046120.11023054
112Tight junction_Homo sapiens_hsa045300.10514694
113Phototransduction_Homo sapiens_hsa047440.08744244
114TGF-beta signaling pathway_Homo sapiens_hsa043500.05604095
115Thyroid cancer_Homo sapiens_hsa052160.05510863
116Hippo signaling pathway_Homo sapiens_hsa043900.03907519
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.03776840
118beta-Alanine metabolism_Homo sapiens_hsa004100.03671721
119Histidine metabolism_Homo sapiens_hsa003400.03602557

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