PSMD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.33281825
2transcription from mitochondrial promoter (GO:0006390)5.86389436
3replication fork processing (GO:0031297)5.55931549
4embryonic process involved in female pregnancy (GO:0060136)5.40213752
5proline metabolic process (GO:0006560)5.36393618
6formation of translation preinitiation complex (GO:0001731)5.19715597
7somatic diversification of immune receptors via somatic mutation (GO:0002566)5.12496930
8somatic hypermutation of immunoglobulin genes (GO:0016446)5.12496930
9establishment of integrated proviral latency (GO:0075713)4.84793096
10DNA deamination (GO:0045006)4.80765782
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.79637894
12regulation of translational fidelity (GO:0006450)4.69360112
13mitochondrial DNA metabolic process (GO:0032042)4.50443603
14proteasome assembly (GO:0043248)4.47295312
15establishment of apical/basal cell polarity (GO:0035089)4.46962670
16viral mRNA export from host cell nucleus (GO:0046784)4.38999460
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.38296446
18telomere maintenance via semi-conservative replication (GO:0032201)4.34335583
19oxidative demethylation (GO:0070989)4.27739188
20mitotic metaphase plate congression (GO:0007080)4.23540410
21DNA strand elongation involved in DNA replication (GO:0006271)4.21293861
22DNA strand renaturation (GO:0000733)4.19767579
23spliceosomal tri-snRNP complex assembly (GO:0000244)4.18033695
24mitotic G1 DNA damage checkpoint (GO:0031571)4.13719612
25* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.13593252
26chromatin remodeling at centromere (GO:0031055)4.07918174
27nuclear pore complex assembly (GO:0051292)4.05280395
28CENP-A containing nucleosome assembly (GO:0034080)4.03911841
29establishment of monopolar cell polarity (GO:0061162)4.02709081
30establishment or maintenance of monopolar cell polarity (GO:0061339)4.02709081
31mRNA cleavage (GO:0006379)4.02571860
32* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.01104104
33regulation of integrin activation (GO:0033623)3.99666819
34nucleotide-excision repair, DNA gap filling (GO:0006297)3.99319743
35positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.98440947
36positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.98440947
37positive regulation of mitotic sister chromatid separation (GO:1901970)3.98440947
38positive regulation of protein homooligomerization (GO:0032464)3.98186731
39base-excision repair (GO:0006284)3.95583743
40cullin deneddylation (GO:0010388)3.95206379
41metaphase plate congression (GO:0051310)3.93788129
42DNA strand elongation (GO:0022616)3.93594820
43* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.90162980
44mitotic sister chromatid segregation (GO:0000070)3.88398470
45negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.85591876
46ribosome assembly (GO:0042255)3.85091342
47* negative regulation of ligase activity (GO:0051352)3.84223841
48* negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.84223841
49* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.83880645
50regulation of posttranscriptional gene silencing (GO:0060147)3.75716119
51regulation of gene silencing by miRNA (GO:0060964)3.75716119
52regulation of gene silencing by RNA (GO:0060966)3.75716119
53DNA replication checkpoint (GO:0000076)3.72292823
54establishment of viral latency (GO:0019043)3.71794710
55DNA unwinding involved in DNA replication (GO:0006268)3.70292363
56telomere maintenance via recombination (GO:0000722)3.69136050
57tRNA aminoacylation for protein translation (GO:0006418)3.68776063
58maturation of 5.8S rRNA (GO:0000460)3.66987930
59nuclear pore organization (GO:0006999)3.65413743
60mitotic G1/S transition checkpoint (GO:0044819)3.65027702
61regulation of sister chromatid cohesion (GO:0007063)3.64139683
62regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.64082969
63DNA double-strand break processing (GO:0000729)3.63970278
64positive regulation of chromosome segregation (GO:0051984)3.61065679
65tRNA aminoacylation (GO:0043039)3.60928609
66amino acid activation (GO:0043038)3.60928609
67negative regulation of JAK-STAT cascade (GO:0046426)3.59131452
68double-strand break repair via nonhomologous end joining (GO:0006303)3.58504324
69non-recombinational repair (GO:0000726)3.58504324
70G1 DNA damage checkpoint (GO:0044783)3.58423376
71regulation of protein homooligomerization (GO:0032462)3.57501671
72DNA topological change (GO:0006265)3.55313806
73meiotic chromosome segregation (GO:0045132)3.54824420
74L-serine metabolic process (GO:0006563)3.54437805
75mitotic nuclear envelope disassembly (GO:0007077)3.53880885
76protein deneddylation (GO:0000338)3.53022898
77regulation of double-strand break repair via homologous recombination (GO:0010569)3.51961656
78dosage compensation (GO:0007549)3.51155207
79sister chromatid segregation (GO:0000819)3.51011962
80histone exchange (GO:0043486)3.50003650
81regulation of RNA export from nucleus (GO:0046831)3.46192364
82* regulation of cellular amino acid metabolic process (GO:0006521)3.42060817
83mitotic recombination (GO:0006312)3.38065863
84poly(A)+ mRNA export from nucleus (GO:0016973)3.37308730
85negative regulation of mRNA processing (GO:0050686)3.37133753
86mitochondrial RNA metabolic process (GO:0000959)3.35523703
87kinetochore assembly (GO:0051382)3.34264590
88regulation of double-strand break repair (GO:2000779)3.31837472
89kinetochore organization (GO:0051383)3.31105205
90spindle checkpoint (GO:0031577)3.30939830
91* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.30827032
92protein localization to chromosome, centromeric region (GO:0071459)3.30788025
93histone arginine methylation (GO:0034969)3.29708844
94nuclear envelope disassembly (GO:0051081)3.29571721
95membrane disassembly (GO:0030397)3.29571721
96telomere maintenance via telomere lengthening (GO:0010833)3.29540053
97termination of RNA polymerase II transcription (GO:0006369)3.28508553
98mitotic spindle checkpoint (GO:0071174)3.27942606
99DNA replication-independent nucleosome organization (GO:0034724)3.27320774
100DNA replication-independent nucleosome assembly (GO:0006336)3.27320774
101* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.26227352
102* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.26227352
103* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.26227352
104purine nucleobase biosynthetic process (GO:0009113)3.24599687
105base-excision repair, AP site formation (GO:0006285)3.22689269
106* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.21710920
107* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.21710920
108* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.21265137
109negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.20382790
110negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.20382790
111negative regulation of mitotic sister chromatid segregation (GO:0033048)3.20382790
112negative regulation of mitotic sister chromatid separation (GO:2000816)3.20382790
113negative regulation of sister chromatid segregation (GO:0033046)3.20382790
114establishment of chromosome localization (GO:0051303)3.20308467
115negative regulation of cell cycle arrest (GO:0071157)3.20037246
116* signal transduction involved in DNA integrity checkpoint (GO:0072401)3.19853856
117* signal transduction involved in DNA damage checkpoint (GO:0072422)3.19853856
118IMP metabolic process (GO:0046040)3.19744335
119negative regulation of fatty acid biosynthetic process (GO:0045717)3.19341347
120DNA ligation (GO:0006266)3.18578805
121* regulation of ubiquitin-protein transferase activity (GO:0051438)3.17536181
122ribosome biogenesis (GO:0042254)3.16984106
123* signal transduction involved in cell cycle checkpoint (GO:0072395)3.15770814
124* positive regulation of ligase activity (GO:0051351)3.14332770
125DNA damage response, detection of DNA damage (GO:0042769)3.12260907
126nucleobase biosynthetic process (GO:0046112)3.09119111
127regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.08735950
128regulation of mitotic spindle checkpoint (GO:1903504)3.08735950
129regulation of chromosome segregation (GO:0051983)3.08254503
130DNA replication initiation (GO:0006270)3.08098045
131regulation of DNA damage checkpoint (GO:2000001)3.08042242
132cellular response to ATP (GO:0071318)3.07248902
133nuclear envelope reassembly (GO:0031468)3.06877268
134mitotic nuclear envelope reassembly (GO:0007084)3.06877268
135pore complex assembly (GO:0046931)3.06466754
136folic acid-containing compound biosynthetic process (GO:0009396)3.05906627
137IMP biosynthetic process (GO:0006188)3.05337868
138mitotic chromosome condensation (GO:0007076)3.04991697
139pre-miRNA processing (GO:0031054)3.04978531
140mitotic spindle assembly checkpoint (GO:0007094)3.04541585
141negative regulation of RNA splicing (GO:0033119)3.04386228
142* regulation of ligase activity (GO:0051340)3.04158545
143regulation of mitotic metaphase/anaphase transition (GO:0030071)3.03121267
144regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.03121267
145chaperone-mediated protein transport (GO:0072321)3.01886245
146embryonic placenta development (GO:0001892)3.01452766
147negative regulation of chromosome segregation (GO:0051985)3.01347940
148DNA integration (GO:0015074)3.01136899
149spindle assembly checkpoint (GO:0071173)3.00218771
150pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.00188393
151peptidyl-arginine omega-N-methylation (GO:0035247)3.00056124
152regulation of centriole replication (GO:0046599)2.99490302
153protein localization to kinetochore (GO:0034501)2.97446088
154DNA replication-dependent nucleosome organization (GO:0034723)2.94234106
155DNA replication-dependent nucleosome assembly (GO:0006335)2.94234106
156regulation of mitotic sister chromatid segregation (GO:0033047)2.94040245
157regulation of sister chromatid segregation (GO:0033045)2.94040245
158regulation of mitotic sister chromatid separation (GO:0010965)2.94040245
159regulation of centrosome cycle (GO:0046605)2.93227662
160mRNA transport (GO:0051028)2.92947420
161mRNA export from nucleus (GO:0006406)2.92345138
162DNA catabolic process, exonucleolytic (GO:0000738)2.91903259
163nuclear envelope organization (GO:0006998)2.91833723
164histone H4-K12 acetylation (GO:0043983)2.90471599
165protein complex localization (GO:0031503)2.89538284
166DNA duplex unwinding (GO:0032508)2.89346425
167* G1/S transition of mitotic cell cycle (GO:0000082)2.88787069
168* cell cycle G1/S phase transition (GO:0044843)2.88787069
169regulation of translational elongation (GO:0006448)2.88454055
170mitotic sister chromatid cohesion (GO:0007064)2.86449926
171regulation of mitochondrial translation (GO:0070129)2.84521810
172spliceosomal snRNP assembly (GO:0000387)2.82882593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.85820375
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.11203885
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43865610
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.29773950
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.05852611
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98986777
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.75025868
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.72293226
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70181143
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.64041289
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.56875501
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48004790
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.48003518
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.48003518
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.48003518
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41289449
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.33304115
18* ETS1_20019798_ChIP-Seq_JURKAT_Human2.22387044
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22247455
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.17487959
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13392147
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.06862164
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05384919
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04944549
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96301811
26DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.96030839
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95936432
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.91762348
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88662560
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.87952093
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86884508
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.86724722
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86560561
34NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.84922022
35XRN2_22483619_ChIP-Seq_HELA_Human1.84167037
36* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82742310
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.82497280
38SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.82305923
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.81349082
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80676080
41* DCP1A_22483619_ChIP-Seq_HELA_Human1.79783817
42GABP_19822575_ChIP-Seq_HepG2_Human1.78518592
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75547051
44TCF3_18692474_ChIP-Seq_MEFs_Mouse1.71178753
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70871158
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66522934
47TCF3_18692474_ChIP-Seq_MESCs_Mouse1.64821044
48AR_21909140_ChIP-Seq_LNCAP_Human1.64448195
49NANOG_21062744_ChIP-ChIP_HESCs_Human1.63123689
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62880817
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.62443633
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.61844785
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.61727048
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.60260452
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.60243510
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.57590235
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.57294474
58POU5F1_16518401_ChIP-PET_MESCs_Mouse1.57221365
59* TTF2_22483619_ChIP-Seq_HELA_Human1.54654125
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54461336
61KDM5A_27292631_Chip-Seq_BREAST_Human1.51920989
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49672823
63* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46182075
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45817542
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44669759
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42453298
67* VDR_23849224_ChIP-Seq_CD4+_Human1.42291552
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41465157
69NANOG_16153702_ChIP-ChIP_HESCs_Human1.39994353
70NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39041018
71ZNF263_19887448_ChIP-Seq_K562_Human1.39034543
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38537274
73ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38257054
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32837364
75SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30493068
76NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.29159304
77VDR_21846776_ChIP-Seq_THP-1_Human1.28038025
78MYC_18940864_ChIP-ChIP_HL60_Human1.27419231
79MYC_22102868_ChIP-Seq_BL_Human1.26980233
80CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25552794
81TFEB_21752829_ChIP-Seq_HELA_Human1.24071329
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23504390
83* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23461213
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.22673683
85* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21257222
86NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.21189227
87OCT4_18692474_ChIP-Seq_MEFs_Mouse1.19046425
88* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17580545
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15863125
90* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.14677019
91* FOXP3_21729870_ChIP-Seq_TREG_Human1.14427782
92ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13719471
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13669076
94* SOX17_20123909_ChIP-Seq_XEN_Mouse1.13410218
95EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10471652
96SOX2_16153702_ChIP-ChIP_HESCs_Human1.09595190
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09346376
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08361880
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07317021
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06323646
101* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.06222321
102POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05416526
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02621002
104* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01935556
105ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00800282
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00027665
107HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99809393
108ELK1_19687146_ChIP-ChIP_HELA_Human0.99443059
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99157091
110SRF_21415370_ChIP-Seq_HL-1_Mouse0.97582328
111NANOG_18692474_ChIP-Seq_MESCs_Mouse0.97139343
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95405148
113PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95303140
114CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94296567
115TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.94112946
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93584560
117NANOG_18692474_ChIP-Seq_MEFs_Mouse0.93430560
118EWS_26573619_Chip-Seq_HEK293_Human0.93286189
119CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92777290
120TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91822178
121HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91393916
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91034421
123ELK1_22589737_ChIP-Seq_MCF10A_Human0.90615650
124TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.89285029
125ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85923646
126ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82269436
127CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79015219
128FLI1_27457419_Chip-Seq_LIVER_Mouse0.78680773
129TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.78185154
130ZNF274_21170338_ChIP-Seq_K562_Hela0.76530064
131TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75553644
132PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74331661
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.72345525
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71968680
135FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.71823552
136CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.71107910

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.36389703
2MP0010030_abnormal_orbit_morphology3.85307802
3MP0010094_abnormal_chromosome_stability3.72027043
4MP0004957_abnormal_blastocyst_morpholog3.54923140
5MP0004233_abnormal_muscle_weight3.20188068
6MP0003111_abnormal_nucleus_morphology3.14498023
7MP0003693_abnormal_embryo_hatching2.95788751
8MP0005171_absent_coat_pigmentation2.77999384
9MP0003077_abnormal_cell_cycle2.65118531
10MP0003890_abnormal_embryonic-extraembry2.57835073
11MP0008932_abnormal_embryonic_tissue2.54013756
12MP0009278_abnormal_bone_marrow2.51528772
13MP0010352_gastrointestinal_tract_polyps2.49779409
14MP0008058_abnormal_DNA_repair2.47267360
15MP0006292_abnormal_olfactory_placode2.39722956
16MP0008877_abnormal_DNA_methylation2.29475644
17MP0004133_heterotaxia2.16206362
18MP0001730_embryonic_growth_arrest2.16201102
19MP0001697_abnormal_embryo_size2.09629556
20MP0003786_premature_aging2.09001981
21MP0003283_abnormal_digestive_organ2.04854446
22MP0002084_abnormal_developmental_patter2.03745015
23MP0003119_abnormal_digestive_system2.03593229
24MP0009697_abnormal_copulation1.98977303
25MP0002653_abnormal_ependyma_morphology1.89836167
26MP0008789_abnormal_olfactory_epithelium1.88810412
27MP0002085_abnormal_embryonic_tissue1.88694312
28MP0004197_abnormal_fetal_growth/weight/1.88098898
29MP0002086_abnormal_extraembryonic_tissu1.87917211
30MP0001529_abnormal_vocalization1.85981911
31MP0000350_abnormal_cell_proliferation1.85657277
32MP0001672_abnormal_embryogenesis/_devel1.85353201
33MP0005380_embryogenesis_phenotype1.85353201
34MP0005076_abnormal_cell_differentiation1.75656388
35MP0001293_anophthalmia1.74929055
36MP0003186_abnormal_redox_activity1.67012104
37MP0002269_muscular_atrophy1.66242121
38MP0003567_abnormal_fetal_cardiomyocyte1.64442137
39MP0003984_embryonic_growth_retardation1.58952248
40MP0003806_abnormal_nucleotide_metabolis1.58544778
41MP0002080_prenatal_lethality1.56390308
42MP0002088_abnormal_embryonic_growth/wei1.55002320
43MP0009053_abnormal_anal_canal1.54939209
44MP0002102_abnormal_ear_morphology1.53472171
45MP0010307_abnormal_tumor_latency1.52937786
46MP0003315_abnormal_perineum_morphology1.47224330
47MP0008007_abnormal_cellular_replicative1.44445383
48MP0006035_abnormal_mitochondrial_morpho1.43602074
49MP0009672_abnormal_birth_weight1.43246136
50MP0002282_abnormal_trachea_morphology1.43193845
51MP0003937_abnormal_limbs/digits/tail_de1.39012267
52MP0006072_abnormal_retinal_apoptosis1.38431589
53MP0002009_preneoplasia1.37272710
54MP0005499_abnormal_olfactory_system1.36596690
55MP0005394_taste/olfaction_phenotype1.36596690
56MP0008995_early_reproductive_senescence1.34222223
57MP0000647_abnormal_sebaceous_gland1.33903252
58MP0003718_maternal_effect1.33524518
59MP0002111_abnormal_tail_morphology1.29719433
60MP0003123_paternal_imprinting1.28054326
61MP0001299_abnormal_eye_distance/1.27805094
62MP0005397_hematopoietic_system_phenotyp1.27487493
63MP0001545_abnormal_hematopoietic_system1.27487493
64MP0003705_abnormal_hypodermis_morpholog1.24783157
65MP0003453_abnormal_keratinocyte_physiol1.17181309
66MP0002233_abnormal_nose_morphology1.16829309
67MP0002938_white_spotting1.15155097
68MP0002249_abnormal_larynx_morphology1.13897085
69MP0003121_genomic_imprinting1.13861894
70MP0003221_abnormal_cardiomyocyte_apopto1.10531234
71MP0000749_muscle_degeneration1.09300832
72MP0000490_abnormal_crypts_of1.08171935
73MP0001286_abnormal_eye_development1.05920321
74MP0002019_abnormal_tumor_incidence1.04811332
75MP0006036_abnormal_mitochondrial_physio1.03595576
76MP0002090_abnormal_vision1.01877193
77MP0003755_abnormal_palate_morphology1.01534688
78MP0003941_abnormal_skin_development1.01327291
79MP0003566_abnormal_cell_adhesion1.00894169
80MP0000313_abnormal_cell_death1.00317295
81MP0001853_heart_inflammation1.00265256
82MP0005266_abnormal_metabolism0.98672273
83MP0005187_abnormal_penis_morphology0.97022184
84MP0004272_abnormal_basement_membrane0.95881356
85MP0002160_abnormal_reproductive_system0.94393647
86MP0004782_abnormal_surfactant_physiolog0.93447456
87MP0001145_abnormal_male_reproductive0.90840739
88MP0004147_increased_porphyrin_level0.89581497
89MP0002114_abnormal_axial_skeleton0.87522124
90MP0001929_abnormal_gametogenesis0.87351843
91MP0001661_extended_life_span0.85018895
92MP0000762_abnormal_tongue_morphology0.84960271
93MP0002234_abnormal_pharynx_morphology0.84060182
94MP0003935_abnormal_craniofacial_develop0.83179605
95MP0005330_cardiomyopathy0.82772872
96MP0000579_abnormal_nail_morphology0.82614306
97MP0002932_abnormal_joint_morphology0.81462829
98MP0005023_abnormal_wound_healing0.81237845
99MP0000432_abnormal_head_morphology0.81016617
100MP0002796_impaired_skin_barrier0.80988101
101MP0000428_abnormal_craniofacial_morphol0.80978799
102MP0000751_myopathy0.79651369
103MP0005501_abnormal_skin_physiology0.79289857
104MP0002210_abnormal_sex_determination0.78717663
105MP0001340_abnormal_eyelid_morphology0.78427442
106MP0003122_maternal_imprinting0.78368664
107MP0002697_abnormal_eye_size0.76389851
108MP0000470_abnormal_stomach_morphology0.76304001
109MP0002092_abnormal_eye_morphology0.75349568
110MP0005395_other_phenotype0.74756379
111MP0000516_abnormal_urinary_system0.74566030
112MP0005367_renal/urinary_system_phenotyp0.74566030
113MP0000371_diluted_coat_color0.74410027
114MP0000462_abnormal_digestive_system0.72784470
115MP0001727_abnormal_embryo_implantation0.72750485
116MP0002332_abnormal_exercise_endurance0.71559546
117MP0010630_abnormal_cardiac_muscle0.70779621
118MP0002877_abnormal_melanocyte_morpholog0.70678397
119MP0000639_abnormal_adrenal_gland0.70347318
120MP0004215_abnormal_myocardial_fiber0.69801901
121MP0003861_abnormal_nervous_system0.69094999
122MP0002163_abnormal_gland_morphology0.68935185
123MP0005408_hypopigmentation0.68918240
124MP0003656_abnormal_erythrocyte_physiolo0.68386593
125MP0000049_abnormal_middle_ear0.68331562
126MP0000653_abnormal_sex_gland0.68101023
127MP0000747_muscle_weakness0.68015039
128MP0000358_abnormal_cell_content/0.67896919
129MP0002116_abnormal_craniofacial_bone0.67763859
130MP0001119_abnormal_female_reproductive0.67430619
131MP0005384_cellular_phenotype0.67256604
132MP0001984_abnormal_olfaction0.67185098
133MP0000537_abnormal_urethra_morphology0.66971772
134MP0005508_abnormal_skeleton_morphology0.65426551
135MP0005623_abnormal_meninges_morphology0.64925229
136MP0001915_intracranial_hemorrhage0.63770702
137MP0009703_decreased_birth_body0.62988714
138MP0003936_abnormal_reproductive_system0.62661868
139MP0003385_abnormal_body_wall0.62252768
140MP0002060_abnormal_skin_morphology0.61728558
141MP0004264_abnormal_extraembryonic_tissu0.61688512
142MP0003942_abnormal_urinary_system0.59996526
143MP0003950_abnormal_plasma_membrane0.58926060
144MP0002751_abnormal_autonomic_nervous0.58431396
145MP0005248_abnormal_Harderian_gland0.58327724

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.65137064
2Facial hemangioma (HP:0000329)4.29162068
3Rectal fistula (HP:0100590)4.28384651
4Rectovaginal fistula (HP:0000143)4.28384651
5Concave nail (HP:0001598)3.85136158
6Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.78972225
7Hypochromic microcytic anemia (HP:0004840)3.77289478
8Vaginal fistula (HP:0004320)3.73450945
9Aplasia/hypoplasia of the humerus (HP:0006507)3.73250743
10Tongue fasciculations (HP:0001308)3.69545855
11Short humerus (HP:0005792)3.69524971
12Absent radius (HP:0003974)3.69239759
13Intestinal fistula (HP:0100819)3.62288456
14Abnormality of the labia minora (HP:0012880)3.62134625
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.59829456
16Muscle fibrillation (HP:0010546)3.49359558
17Chromsome breakage (HP:0040012)3.48336990
18Aplasia involving forearm bones (HP:0009822)3.44177093
19Absent forearm bone (HP:0003953)3.44177093
20Orthostatic hypotension (HP:0001278)3.42051913
21Annular pancreas (HP:0001734)3.38195173
22Selective tooth agenesis (HP:0001592)3.36921705
23Increased serum pyruvate (HP:0003542)3.32802399
24Abnormality of the astrocytes (HP:0100707)3.27871706
25Astrocytoma (HP:0009592)3.27871706
26Poikiloderma (HP:0001029)3.27137680
27Abnormality of glycolysis (HP:0004366)3.19695918
28Ulnar bowing (HP:0003031)3.19253986
29Absent thumb (HP:0009777)3.18279406
30Abnormal hemoglobin (HP:0011902)3.16724338
31Coronal craniosynostosis (HP:0004440)3.12261760
32Acute necrotizing encephalopathy (HP:0006965)3.09957553
33Turricephaly (HP:0000262)3.09095059
34Ependymoma (HP:0002888)3.05561022
35Alopecia of scalp (HP:0002293)3.05468502
36Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.03782079
37Vertebral hypoplasia (HP:0008417)3.03782079
38Volvulus (HP:0002580)3.03662839
39Patellar aplasia (HP:0006443)3.01131686
40Acute encephalopathy (HP:0006846)2.93678175
41Basal cell carcinoma (HP:0002671)2.92712448
42Cortical dysplasia (HP:0002539)2.92102871
43Meckel diverticulum (HP:0002245)2.87946590
44Squamous cell carcinoma (HP:0002860)2.87303433
45Multiple enchondromatosis (HP:0005701)2.87105411
46Abnormal mitochondria in muscle tissue (HP:0008316)2.85221024
47Intestinal atresia (HP:0011100)2.84655543
48Abnormal lung lobation (HP:0002101)2.83562093
49Microvesicular hepatic steatosis (HP:0001414)2.83351490
50Congenital hip dislocation (HP:0001374)2.83161596
51Aplasia/Hypoplasia of the patella (HP:0006498)2.78138829
52Increased nuchal translucency (HP:0010880)2.69675842
53Short chin (HP:0000331)2.68775091
54Premature graying of hair (HP:0002216)2.68053423
55Pustule (HP:0200039)2.66192719
56Increased hepatocellular lipid droplets (HP:0006565)2.61875479
57Breast hypoplasia (HP:0003187)2.60950500
58Increased IgM level (HP:0003496)2.60722616
59Dysautonomia (HP:0002459)2.59268750
60Broad alveolar ridges (HP:0000187)2.57100817
61Glioma (HP:0009733)2.53967729
62Male infertility (HP:0003251)2.53847511
63Increased CSF lactate (HP:0002490)2.52709927
64Rhabdomyosarcoma (HP:0002859)2.51656007
65Cerebral edema (HP:0002181)2.49784615
66Abnormality of chromosome stability (HP:0003220)2.48386185
67Abnormality of the anterior horn cell (HP:0006802)2.45879026
68Degeneration of anterior horn cells (HP:0002398)2.45879026
69Anteriorly placed anus (HP:0001545)2.45357630
70Spastic diplegia (HP:0001264)2.43418059
71Aplasia/Hypoplasia of the uvula (HP:0010293)2.39558361
72Abnormality of the aortic arch (HP:0012303)2.36761007
73Alacrima (HP:0000522)2.33733705
74Abnormality of abdominal situs (HP:0011620)2.33303787
75Abdominal situs inversus (HP:0003363)2.33303787
76Abnormality of the preputium (HP:0100587)2.32690494
77Lipid accumulation in hepatocytes (HP:0006561)2.29422519
78Progressive macrocephaly (HP:0004481)2.29382125
79Cerebral hypomyelination (HP:0006808)2.27016730
80Neoplasm of the oral cavity (HP:0100649)2.25407369
81Vertebral fusion (HP:0002948)2.24626949
82Diaphragmatic weakness (HP:0009113)2.23682756
83Mitochondrial inheritance (HP:0001427)2.22773733
84Increased serum lactate (HP:0002151)2.19876777
85Bifid uvula (HP:0000193)2.16171160
86Choanal stenosis (HP:0000452)2.16026729
87Small intestinal stenosis (HP:0012848)2.14946003
88Duodenal stenosis (HP:0100867)2.14946003
89Birth length less than 3rd percentile (HP:0003561)2.14571404
90Abnormal number of incisors (HP:0011064)2.13835713
91Horseshoe kidney (HP:0000085)2.13480662
92Shoulder girdle muscle weakness (HP:0003547)2.12744861
93Aplasia of the musculature (HP:0100854)2.11133659
94Nephroblastoma (Wilms tumor) (HP:0002667)2.11046608
95Adrenal hypoplasia (HP:0000835)2.07779085
96Postnatal microcephaly (HP:0005484)2.06240798
97Capillary hemangiomas (HP:0005306)2.05667145
98Abnormality of the umbilical cord (HP:0010881)2.04618852
99Embryonal renal neoplasm (HP:0011794)2.01327708
100Hamartoma (HP:0010566)2.00809788
101Ectopic kidney (HP:0000086)2.00345910
102Medulloblastoma (HP:0002885)1.97542060
103Hypoplasia of the radius (HP:0002984)1.97497280
104Gastrointestinal atresia (HP:0002589)1.97443151
105Pancreatic islet-cell hyperplasia (HP:0004510)1.97257576
106Cerebral aneurysm (HP:0004944)1.96222936
107Aplasia/Hypoplasia involving the musculature (HP:0001460)1.96031690
108Spinal muscular atrophy (HP:0007269)1.94961959
109Abnormality of the calcaneus (HP:0008364)1.94198898
110Septo-optic dysplasia (HP:0100842)1.92595163
111Neoplasm of the colon (HP:0100273)1.92512195
112Neoplasm of striated muscle (HP:0009728)1.92440573
113Lactic acidosis (HP:0003128)1.92332203
114Exercise intolerance (HP:0003546)1.92188793
115Popliteal pterygium (HP:0009756)1.91793122
116Secondary amenorrhea (HP:0000869)1.91245404
117Abnormality of the ileum (HP:0001549)1.90990080
118Neoplasm of the adrenal gland (HP:0100631)1.90609442
119Hepatocellular necrosis (HP:0001404)1.89878840
120Reticulocytopenia (HP:0001896)1.88855340
121Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88392263
122Abnormality of alanine metabolism (HP:0010916)1.88392263
123Hyperalaninemia (HP:0003348)1.88392263
124Colon cancer (HP:0003003)1.88268623
125Type I transferrin isoform profile (HP:0003642)1.86845459
126Metaphyseal cupping (HP:0003021)1.86621425
127Abnormality of serum amino acid levels (HP:0003112)1.86195564
128Increased number of teeth (HP:0011069)1.86108718
129Abnormality of the duodenum (HP:0002246)1.85817071
130Hypotelorism (HP:0000601)1.84349931
131CNS hypomyelination (HP:0003429)1.84078811
132Short 5th finger (HP:0009237)1.83400500
133Abnormalities of placenta or umbilical cord (HP:0001194)1.82218131
134Abnormality of the lower motor neuron (HP:0002366)1.81829868
135Abnormality of the carotid arteries (HP:0005344)1.81703388
136Missing ribs (HP:0000921)1.80936587
137Agnosia (HP:0010524)1.80844324
138Hypotrichosis (HP:0001006)1.80690774
139Abnormality of male internal genitalia (HP:0000022)1.80628146
140Prominent metopic ridge (HP:0005487)1.80537922
141Decreased lacrimation (HP:0000633)1.80021982
142Upper limb muscle weakness (HP:0003484)1.79948328
143Hyperglycinemia (HP:0002154)1.79450786
144Abnormality of placental membranes (HP:0011409)1.79146234
145Amniotic constriction ring (HP:0009775)1.79146234
146Leukodystrophy (HP:0002415)1.78197350
147Microglossia (HP:0000171)1.77761241
148Bifid tongue (HP:0010297)1.77651236
149Abnormality of methionine metabolism (HP:0010901)1.77540697
150Calcaneovalgus deformity (HP:0001848)1.77086928
151Trismus (HP:0000211)1.75315217
152Facial cleft (HP:0002006)1.75138526
153Large for gestational age (HP:0001520)1.74759784
154Hypochromic anemia (HP:0001931)1.73767249
155Hypokinesia (HP:0002375)1.73405061
156Shawl scrotum (HP:0000049)1.71499073
157Stenosis of the external auditory canal (HP:0000402)1.70958499
158Bowing of the arm (HP:0006488)1.70859160
159Bowed forearm bones (HP:0003956)1.70859160
160Premature skin wrinkling (HP:0100678)1.69297967
161Sparse eyelashes (HP:0000653)1.68886664
162Abnormality of the fetal cardiovascular system (HP:0010948)1.67743440
163Abnormal umbilical cord blood vessels (HP:0011403)1.67743440
164Single umbilical artery (HP:0001195)1.67743440
165Exercise-induced muscle cramps (HP:0003710)1.66245299
166Sensory axonal neuropathy (HP:0003390)1.66210655
167Absent septum pellucidum (HP:0001331)1.65459991
168Abnormality of the metopic suture (HP:0005556)1.64490540
169Proximal placement of thumb (HP:0009623)1.63445291
170Hepatic necrosis (HP:0002605)1.62059608
171Abnormality of the septum pellucidum (HP:0007375)1.60590549
172Increased intramyocellular lipid droplets (HP:0012240)1.59839120
173Supernumerary spleens (HP:0009799)1.59747959
174Abnormality of the musculature of the pelvis (HP:0001469)1.59141829
175Abnormality of the hip-girdle musculature (HP:0001445)1.59141829
176Hypoplastic pelvis (HP:0008839)1.58155192
177Premature ovarian failure (HP:0008209)1.58140607
178Aplasia/Hypoplasia of the sacrum (HP:0008517)1.56227883
179Deviation of the thumb (HP:0009603)1.54604296
180Respiratory failure (HP:0002878)1.54057399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.64045105
2DDR24.27518971
3MAP3K63.53344437
4PBK3.33064390
5MAP3K113.24347959
6BUB12.73680730
7STK162.65742872
8NEK12.59476235
9MAPK152.56012141
10CDC72.54349455
11PINK12.36419618
12WEE12.35723149
13ZAK2.33248200
14FGR2.31174991
15EIF2AK32.28521617
16TYRO32.19409082
17DAPK12.02117630
18MATK2.01942124
19CDK72.01669465
20VRK22.00745295
21TRIM281.96118647
22BCR1.85480647
23BMX1.85433811
24EIF2AK11.84530430
25MST41.82569883
26PIM21.80984664
27MKNK21.78041415
28UHMK11.75793168
29LATS21.74269043
30PDGFRA1.69369077
31PLK11.68053625
32YES11.65703090
33AKT31.62246812
34PDK21.61558136
35DYRK1B1.48716289
36EPHA21.47298372
37NME11.46579575
38CDK61.41265552
39CHEK21.37440574
40ERBB41.35307018
41CSK1.33532274
42TESK21.33303184
43CDK121.31019962
44PLK21.26687949
45TRPM71.20817654
46NEK21.20355010
47NUAK11.18382499
48TTK1.17967621
49PRKD21.15012020
50ATR1.11925168
51PRPF4B1.08967882
52VRK11.07986583
53SCYL21.07257699
54RPS6KB21.06738264
55AURKA1.06554959
56MAP3K121.06519489
57LATS11.05923580
58TSSK61.04819073
59PNCK1.00407295
60PIM11.00036933
61TAF11.00025229
62RPS6KC10.99680710
63RPS6KL10.99680710
64EIF2AK20.94973162
65PHKG20.94420210
66PHKG10.94420210
67NME20.94302831
68AURKB0.94214233
69BRSK20.94017626
70DYRK30.91335028
71MAP2K70.88038907
72CSNK1G30.85368983
73CHEK10.83558312
74CSNK1G10.82422124
75CDC42BPA0.80174410
76RPS6KA60.79626793
77WNK30.79305669
78MTOR0.78211242
79CSNK1A1L0.78118107
80CSNK1G20.77652894
81* CDK20.76190599
82ERBB30.74629781
83PLK30.74563813
84GSK3A0.72408381
85MAP3K40.70979559
86STK38L0.70121583
87BCKDK0.69410352
88MINK10.69035552
89CSNK2A10.67368144
90PAK40.66682054
91TNIK0.64890929
92TAOK20.64812465
93ALK0.64015780
94ATM0.63997510
95RPS6KA40.63150429
96MAP3K80.62686185
97MAPK110.62628557
98PDK30.61690334
99PDK40.61690334
100CSNK2A20.61599257
101BMPR1B0.59542189
102TIE10.58896335
103MKNK10.58500077
104STK30.58368988
105MAP4K20.57774319
106RPS6KA10.57200182
107ACVR1B0.57169700
108PASK0.55733842
109SRPK10.55516044
110CDK10.55123360
111FGFR10.53599357
112BRAF0.52583418
113DMPK0.50903300
114MAP3K100.50823160
115STK40.50380603
116PRKD30.49869143
117CDK80.49683590
118DYRK20.49512360
119LIMK10.49059129
120PAK10.47116902
121MST1R0.46419501
122MUSK0.46219818
123STK390.45920124
124TESK10.45906188
125RPS6KB10.45552816
126CLK10.45068706
127CDK40.44842544
128BRSK10.43253796
129CCNB10.42254624
130CSNK1E0.41987080
131STK100.40993975
132PAK30.40151671
133EGFR0.40051161
134WNK40.39561551
135PRKCI0.39171746
136CDK140.38963712
137PTK20.38937372
138CDK150.36743348
139PLK40.36369570
140ABL20.36214929
141MET0.36088106
142PRKAA10.35637037
143TLK10.35470504
144RAF10.35467808
145CDK180.35266801
146KSR10.35217129
147CDK11A0.34880620
148OBSCN0.34024093
149PAK20.33258390
150MAPK100.32877447
151MAPK10.31050812
152PRKDC0.29485310

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.23075548
2DNA replication_Homo sapiens_hsa030304.72934677
3Base excision repair_Homo sapiens_hsa034104.20610276
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.47783669
5RNA transport_Homo sapiens_hsa030133.18973903
6Fatty acid biosynthesis_Homo sapiens_hsa000613.00983277
7Spliceosome_Homo sapiens_hsa030402.98888114
8Nucleotide excision repair_Homo sapiens_hsa034202.96699979
9Protein export_Homo sapiens_hsa030602.51034200
10Homologous recombination_Homo sapiens_hsa034402.46947484
11Cell cycle_Homo sapiens_hsa041102.38724815
12mRNA surveillance pathway_Homo sapiens_hsa030152.24837176
13* Proteasome_Homo sapiens_hsa030502.20271773
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14445923
15One carbon pool by folate_Homo sapiens_hsa006702.08557942
16Biosynthesis of amino acids_Homo sapiens_hsa012301.92477697
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.91361707
18Fanconi anemia pathway_Homo sapiens_hsa034601.81527014
19Vitamin B6 metabolism_Homo sapiens_hsa007501.80799472
20Propanoate metabolism_Homo sapiens_hsa006401.74841420
21RNA polymerase_Homo sapiens_hsa030201.71488029
22p53 signaling pathway_Homo sapiens_hsa041151.68885864
23Fatty acid elongation_Homo sapiens_hsa000621.58378114
24Oxidative phosphorylation_Homo sapiens_hsa001901.57584514
25Hippo signaling pathway_Homo sapiens_hsa043901.57573583
26Parkinsons disease_Homo sapiens_hsa050121.56349282
27Oocyte meiosis_Homo sapiens_hsa041141.49258951
28Hedgehog signaling pathway_Homo sapiens_hsa043401.34050820
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31561704
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30459838
31mTOR signaling pathway_Homo sapiens_hsa041501.30354627
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30237038
33Arginine and proline metabolism_Homo sapiens_hsa003301.27331310
34Ribosome_Homo sapiens_hsa030101.24603103
35Pyrimidine metabolism_Homo sapiens_hsa002401.22347888
36Adherens junction_Homo sapiens_hsa045201.20702897
37RNA degradation_Homo sapiens_hsa030181.16080554
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13295465
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13132272
40Basal transcription factors_Homo sapiens_hsa030221.12972105
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11292571
42TGF-beta signaling pathway_Homo sapiens_hsa043501.10682178
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03978412
44Sulfur relay system_Homo sapiens_hsa041221.02590790
45Folate biosynthesis_Homo sapiens_hsa007901.01021701
46Bladder cancer_Homo sapiens_hsa052191.00870277
47Non-homologous end-joining_Homo sapiens_hsa034500.94711957
48Fructose and mannose metabolism_Homo sapiens_hsa000510.92325331
49Alzheimers disease_Homo sapiens_hsa050100.89925381
50Basal cell carcinoma_Homo sapiens_hsa052170.89767412
51Notch signaling pathway_Homo sapiens_hsa043300.87487264
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86914040
53Shigellosis_Homo sapiens_hsa051310.85432695
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.84793812
55Carbon metabolism_Homo sapiens_hsa012000.83915553
56Fatty acid metabolism_Homo sapiens_hsa012120.78969249
57Tight junction_Homo sapiens_hsa045300.78411544
58Circadian rhythm_Homo sapiens_hsa047100.76640553
59Wnt signaling pathway_Homo sapiens_hsa043100.74966204
60Selenocompound metabolism_Homo sapiens_hsa004500.74166358
61Viral carcinogenesis_Homo sapiens_hsa052030.74007500
62Sulfur metabolism_Homo sapiens_hsa009200.73308036
63Thyroid cancer_Homo sapiens_hsa052160.71787914
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71280484
65MicroRNAs in cancer_Homo sapiens_hsa052060.70965100
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69085761
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64752915
68* Epstein-Barr virus infection_Homo sapiens_hsa051690.63804547
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63455905
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62974707
71Colorectal cancer_Homo sapiens_hsa052100.62806417
72beta-Alanine metabolism_Homo sapiens_hsa004100.60211465
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59894430
74Glutathione metabolism_Homo sapiens_hsa004800.59682617
75Cardiac muscle contraction_Homo sapiens_hsa042600.59258516
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.58772777
77Fatty acid degradation_Homo sapiens_hsa000710.58585770
78Galactose metabolism_Homo sapiens_hsa000520.58255878
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57420653
80Lysine degradation_Homo sapiens_hsa003100.55704722
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.55356406
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55202256
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54704865
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53640512
85Legionellosis_Homo sapiens_hsa051340.53620080
86Butanoate metabolism_Homo sapiens_hsa006500.53284323
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51802905
88Pyruvate metabolism_Homo sapiens_hsa006200.51135808
89N-Glycan biosynthesis_Homo sapiens_hsa005100.50455437
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44322986
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43171994
92Viral myocarditis_Homo sapiens_hsa054160.42556966
93Steroid biosynthesis_Homo sapiens_hsa001000.42502311
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41494039
95Pentose phosphate pathway_Homo sapiens_hsa000300.40946769
96AMPK signaling pathway_Homo sapiens_hsa041520.40900640
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40049423
98Vibrio cholerae infection_Homo sapiens_hsa051100.39074350
99Peroxisome_Homo sapiens_hsa041460.38942082
100HTLV-I infection_Homo sapiens_hsa051660.38023889
101Purine metabolism_Homo sapiens_hsa002300.36982785
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36787011
103VEGF signaling pathway_Homo sapiens_hsa043700.34442588
104Gap junction_Homo sapiens_hsa045400.33789877
105Insulin signaling pathway_Homo sapiens_hsa049100.33323306
106Tryptophan metabolism_Homo sapiens_hsa003800.33092026
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32746526
108Small cell lung cancer_Homo sapiens_hsa052220.31754574
109Arginine biosynthesis_Homo sapiens_hsa002200.31603611
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30860111
111Huntingtons disease_Homo sapiens_hsa050160.30206339
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30117519
113Proteoglycans in cancer_Homo sapiens_hsa052050.28605959
114Systemic lupus erythematosus_Homo sapiens_hsa053220.27799775
115HIF-1 signaling pathway_Homo sapiens_hsa040660.26209379
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.25433473
117Chronic myeloid leukemia_Homo sapiens_hsa052200.22319948
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.22181021
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21019636
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20018729
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19408393
122Herpes simplex infection_Homo sapiens_hsa051680.14940789
123Metabolic pathways_Homo sapiens_hsa011000.14480326
124Melanoma_Homo sapiens_hsa052180.13200738
125Pathways in cancer_Homo sapiens_hsa052000.13064147
126Fat digestion and absorption_Homo sapiens_hsa049750.12877254
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.11820624
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10703354
129Regulation of autophagy_Homo sapiens_hsa041400.08840532
130Collecting duct acid secretion_Homo sapiens_hsa049660.06627003
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.05382098

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