PSMD10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)6.40033107
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.08741453
3protein neddylation (GO:0045116)5.91193467
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.75418455
5ATP synthesis coupled proton transport (GO:0015986)5.75418455
6piRNA metabolic process (GO:0034587)5.06365412
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.96934047
8ribosomal small subunit biogenesis (GO:0042274)4.88742848
9chaperone-mediated protein transport (GO:0072321)4.85162379
10male meiosis I (GO:0007141)4.83227390
11chromosome organization involved in meiosis (GO:0070192)4.67421949
12respiratory electron transport chain (GO:0022904)4.42379723
13meiosis I (GO:0007127)4.38530438
14electron transport chain (GO:0022900)4.31221433
15male meiosis (GO:0007140)4.21563542
16ribosomal small subunit assembly (GO:0000028)4.20301688
17cullin deneddylation (GO:0010388)4.19853632
18* proteasome assembly (GO:0043248)4.19453400
19mitochondrial respiratory chain complex I assembly (GO:0032981)4.10551894
20NADH dehydrogenase complex assembly (GO:0010257)4.10551894
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.10551894
22viral transcription (GO:0019083)4.05476921
23* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.04470128
24protein complex biogenesis (GO:0070271)3.96440981
25translational termination (GO:0006415)3.95107753
26* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.94530953
27cotranslational protein targeting to membrane (GO:0006613)3.94394490
28protein deneddylation (GO:0000338)3.93362995
29* antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.89478354
30chromatin remodeling at centromere (GO:0031055)3.88636137
31CENP-A containing nucleosome assembly (GO:0034080)3.87378134
32* regulation of cellular amino acid metabolic process (GO:0006521)3.85922416
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.84130536
34protein targeting to ER (GO:0045047)3.82870821
357-methylguanosine mRNA capping (GO:0006370)3.80661542
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.77131393
37RNA capping (GO:0036260)3.76495260
387-methylguanosine RNA capping (GO:0009452)3.76495260
39resolution of meiotic recombination intermediates (GO:0000712)3.75689329
40maturation of SSU-rRNA (GO:0030490)3.75322174
41regulation of meiosis I (GO:0060631)3.71677911
42* negative regulation of ligase activity (GO:0051352)3.68810520
43* negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.68810520
44ribosomal large subunit biogenesis (GO:0042273)3.68783249
45DNA ligation (GO:0006266)3.68655003
46* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.67163703
47protein localization to endoplasmic reticulum (GO:0070972)3.67003151
48establishment of protein localization to endoplasmic reticulum (GO:0072599)3.64004386
49mitochondrial respiratory chain complex assembly (GO:0033108)3.61803099
50meiotic nuclear division (GO:0007126)3.61388882
51* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.60195165
52* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.60195165
53DNA methylation involved in gamete generation (GO:0043046)3.57643441
54histone exchange (GO:0043486)3.56177423
55termination of RNA polymerase III transcription (GO:0006386)3.55013924
56transcription elongation from RNA polymerase III promoter (GO:0006385)3.55013924
57* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.54020237
58* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.54020237
59* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.54020237
60DNA damage response, detection of DNA damage (GO:0042769)3.53477270
61synaptonemal complex assembly (GO:0007130)3.51726911
62* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.50467285
63L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.50139856
64neutrophil activation involved in immune response (GO:0002283)3.44767988
65* signal transduction involved in DNA integrity checkpoint (GO:0072401)3.37215824
66* signal transduction involved in DNA damage checkpoint (GO:0072422)3.37215824
67* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36005979
68synaptonemal complex organization (GO:0070193)3.34843038
69DNA synthesis involved in DNA repair (GO:0000731)3.34814446
70meiotic cell cycle process (GO:1903046)3.34781669
71* signal transduction involved in cell cycle checkpoint (GO:0072395)3.31554337
72fatty acid elongation (GO:0030497)3.30894602
73central nervous system myelination (GO:0022010)3.28935832
74axon ensheathment in central nervous system (GO:0032291)3.28935832
75establishment of viral latency (GO:0019043)3.26325720
76translational elongation (GO:0006414)3.25391651
77* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24737301
78viral life cycle (GO:0019058)3.24300616
79* antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.22773181
80cellular protein complex disassembly (GO:0043624)3.21434751
81translation (GO:0006412)3.19301131
82protein targeting to mitochondrion (GO:0006626)3.16364428
83intraciliary transport (GO:0042073)3.11131412
84regulation of mitochondrial translation (GO:0070129)3.10601619
85DNA double-strand break processing (GO:0000729)3.09926544
86establishment of integrated proviral latency (GO:0075713)3.09676673
87DNA catabolic process, exonucleolytic (GO:0000738)3.07844789
88histone H2A acetylation (GO:0043968)3.07799218
89RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06021870
90tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06021870
91spliceosomal snRNP assembly (GO:0000387)3.05976157
92establishment of protein localization to mitochondrion (GO:0072655)3.04521774
93signal peptide processing (GO:0006465)3.03540477
94GTP biosynthetic process (GO:0006183)3.03003047
95aldehyde catabolic process (GO:0046185)3.02475258
96* regulation of cellular amine metabolic process (GO:0033238)3.00056334
97* positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.98946662
98ribosome assembly (GO:0042255)2.96100644
99* positive regulation of ligase activity (GO:0051351)2.95949591
100respiratory chain complex IV assembly (GO:0008535)2.95625187
101translational initiation (GO:0006413)2.95232134
102protein K11-linked ubiquitination (GO:0070979)2.95060725
103spindle checkpoint (GO:0031577)2.94884895
104mitotic metaphase plate congression (GO:0007080)2.92085741
105reciprocal DNA recombination (GO:0035825)2.89992438
106reciprocal meiotic recombination (GO:0007131)2.89992438
107mitotic spindle checkpoint (GO:0071174)2.89821275
108nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89502417
109respiratory burst (GO:0045730)2.88932299
110DNA replication-independent nucleosome assembly (GO:0006336)2.88681521
111DNA replication-independent nucleosome organization (GO:0034724)2.88681521
112organelle disassembly (GO:1903008)2.87681908
113meiotic chromosome segregation (GO:0045132)2.86627142
114peptidyl-histidine modification (GO:0018202)2.85005724
115telomere maintenance via semi-conservative replication (GO:0032201)2.84667244
116protein localization to mitochondrion (GO:0070585)2.84598693
117regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84145324
118regulation of mitotic spindle checkpoint (GO:1903504)2.84145324
119iron-sulfur cluster assembly (GO:0016226)2.82884777
120metallo-sulfur cluster assembly (GO:0031163)2.82884777
121cytochrome complex assembly (GO:0017004)2.82401284
122nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.81371000
123protein K6-linked ubiquitination (GO:0085020)2.78844241
124rRNA modification (GO:0000154)2.77351984
125dopamine transport (GO:0015872)2.77055723
126* DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.77045934
127metaphase plate congression (GO:0051310)2.76788667
128hydrogen ion transmembrane transport (GO:1902600)2.75769229
129negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.75599032
130negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.75599032
131negative regulation of mitotic sister chromatid segregation (GO:0033048)2.75599032
132negative regulation of mitotic sister chromatid separation (GO:2000816)2.75599032
133negative regulation of sister chromatid segregation (GO:0033046)2.75599032
134mitotic spindle assembly checkpoint (GO:0007094)2.74711713
135inner mitochondrial membrane organization (GO:0007007)2.73917635
136sequestering of actin monomers (GO:0042989)2.73542493
137spindle assembly checkpoint (GO:0071173)2.72364904
138transcription elongation from RNA polymerase I promoter (GO:0006362)2.69308225
139GPI anchor biosynthetic process (GO:0006506)2.68751544
140cellular component biogenesis (GO:0044085)2.68739424
141transcription-coupled nucleotide-excision repair (GO:0006283)2.67509595
142exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66438666
143* positive regulation of cell cycle arrest (GO:0071158)2.65060034
144protein targeting to membrane (GO:0006612)2.61459231
145* regulation of ubiquitin-protein transferase activity (GO:0051438)2.61315052
146* regulation of ligase activity (GO:0051340)2.60566659
147termination of RNA polymerase I transcription (GO:0006363)2.56726891
148protein complex disassembly (GO:0043241)2.55257731
149phagosome maturation (GO:0090382)2.54035068
150positive regulation of actin filament depolymerization (GO:0030836)2.54000880
151pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.53848074
152regulation of metalloenzyme activity (GO:0048552)2.53700660
153ribonucleoprotein complex biogenesis (GO:0022613)2.53117396
154amino acid salvage (GO:0043102)2.53058920
155L-methionine biosynthetic process (GO:0071265)2.53058920

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.97958612
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.85453473
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.67907644
4* EST1_17652178_ChIP-ChIP_JURKAT_Human4.30951302
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.65003853
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.52321483
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.39650084
8* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.37712655
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.29869570
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.17188697
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.12962100
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01498908
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.89663960
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.84083022
15ELK1_19687146_ChIP-ChIP_HELA_Human2.71227643
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.70706059
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.53794187
18VDR_23849224_ChIP-Seq_CD4+_Human2.52632173
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.47737813
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.46943024
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.45070302
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44958218
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.37289553
24DCP1A_22483619_ChIP-Seq_HELA_Human2.33339293
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28277584
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.24986201
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15032727
28ZNF274_21170338_ChIP-Seq_K562_Hela2.12598438
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.07701785
30FOXP3_21729870_ChIP-Seq_TREG_Human1.97417267
31HOXB4_20404135_ChIP-ChIP_EML_Mouse1.95421976
32ELK1_22589737_ChIP-Seq_MCF10A_Human1.93133402
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92773411
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91329813
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84650224
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83880995
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.83320052
38E2F7_22180533_ChIP-Seq_HELA_Human1.80922571
39TTF2_22483619_ChIP-Seq_HELA_Human1.76167206
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73816142
41XRN2_22483619_ChIP-Seq_HELA_Human1.72099344
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71183409
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64789887
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55844100
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54289267
46* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.53021411
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52422348
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49344499
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48800400
50IRF1_19129219_ChIP-ChIP_H3396_Human1.48205787
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46735573
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43796859
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.43124052
54GABP_19822575_ChIP-Seq_HepG2_Human1.42831286
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.42821428
56TAF15_26573619_Chip-Seq_HEK293_Human1.41371264
57FUS_26573619_Chip-Seq_HEK293_Human1.36257855
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34045141
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.30327530
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30046045
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29938059
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29755760
63MYC_18940864_ChIP-ChIP_HL60_Human1.29471541
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28064604
65* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27882840
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22725816
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22041083
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21536519
69SPI1_23547873_ChIP-Seq_NB4_Human1.21083329
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18290826
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.17384890
72SOX2_16153702_ChIP-ChIP_HESCs_Human1.16763085
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16469777
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16341665
75P300_19829295_ChIP-Seq_ESCs_Human1.14060194
76VDR_22108803_ChIP-Seq_LS180_Human1.13718151
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.13680662
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13540440
79EWS_26573619_Chip-Seq_HEK293_Human1.13512228
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.11878625
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11267390
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09869013
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08220807
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07538422
85SOX17_20123909_ChIP-Seq_XEN_Mouse1.06544965
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06509606
87POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05893643
88* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02920910
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02423943
90IGF1R_20145208_ChIP-Seq_DFB_Human1.01046515
91RNF2_27304074_Chip-Seq_NSC_Mouse1.00525428
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00425869
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00164951
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99810199
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98174327
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97057870
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96485811
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96399515
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94371704
100ER_23166858_ChIP-Seq_MCF-7_Human0.94125869
101TP53_22573176_ChIP-Seq_HFKS_Human0.93054214
102KDM5A_27292631_Chip-Seq_BREAST_Human0.89819866
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88504783
104SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86450161
105FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.85131003
106CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84661538
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83927074
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83747587
109AR_21909140_ChIP-Seq_LNCAP_Human0.83383069
110FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83155707
111FOXA1_25329375_ChIP-Seq_VCAP_Human0.83155707
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82928420
113MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82090633
114ELF5_23300383_ChIP-Seq_T47D_Human0.80227938
115* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.79706968
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.76497497
117PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.74668139
118MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.73736266
119BMI1_23680149_ChIP-Seq_NPCS_Mouse0.73523096
120SALL4_22934838_ChIP-ChIP_CD34+_Human0.72861869
121FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71169560
122TFEB_21752829_ChIP-Seq_HELA_Human0.70288985
123SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.69886613
124SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.68801117
125STAT1_20625510_ChIP-Seq_HELA_Human0.68782680
126MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.68237414
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.67943956
128CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.67534621
129JUN_21703547_ChIP-Seq_K562_Human0.67425200
130POU5F1_16153702_ChIP-ChIP_HESCs_Human0.66960380

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization4.35314574
2MP0009379_abnormal_foot_pigmentation3.15807199
3MP0009785_altered_susceptibility_to3.05869715
4MP0001905_abnormal_dopamine_level2.95547941
5MP0002148_abnormal_hypersensitivity_rea2.93270563
6MP0003724_increased_susceptibility_to2.66860165
7MP0001835_abnormal_antigen_presentation2.62796931
8MP0003880_abnormal_central_pattern2.62116595
9MP0003186_abnormal_redox_activity2.60965453
10MP0008057_abnormal_DNA_replication2.58844643
11MP0005671_abnormal_response_to2.46470496
12MP0008789_abnormal_olfactory_epithelium2.39544376
13MP0006082_CNS_inflammation2.24349664
14MP0002210_abnormal_sex_determination2.17492078
15MP0005000_abnormal_immune_tolerance2.07054356
16MP0003111_abnormal_nucleus_morphology1.96118187
17MP0001929_abnormal_gametogenesis1.93947672
18MP0006292_abnormal_olfactory_placode1.92044646
19MP0005394_taste/olfaction_phenotype1.92000003
20MP0005499_abnormal_olfactory_system1.92000003
21MP0005025_abnormal_response_to1.90222783
22MP0002102_abnormal_ear_morphology1.86510533
23MP0004957_abnormal_blastocyst_morpholog1.86182512
24MP0002277_abnormal_respiratory_mucosa1.84952715
25MP0000920_abnormal_myelination1.84115013
26MP0010030_abnormal_orbit_morphology1.83094450
27MP0008995_early_reproductive_senescence1.82419109
28MP0002163_abnormal_gland_morphology1.78294663
29MP0003950_abnormal_plasma_membrane1.77093436
30MP0003136_yellow_coat_color1.76561985
31MP0001145_abnormal_male_reproductive1.73190302
32MP0002419_abnormal_innate_immunity1.68957594
33MP0000372_irregular_coat_pigmentation1.68765024
34MP0008260_abnormal_autophagy1.67971410
35MP0000653_abnormal_sex_gland1.67677904
36MP0005408_hypopigmentation1.66056244
37MP0004381_abnormal_hair_follicle1.64020458
38MP0008932_abnormal_embryonic_tissue1.61747104
39MP0002723_abnormal_immune_serum1.60770950
40MP0001293_anophthalmia1.59998882
41MP0003937_abnormal_limbs/digits/tail_de1.57899910
42MP0002160_abnormal_reproductive_system1.56240780
43MP0006276_abnormal_autonomic_nervous1.55739095
44MP0006072_abnormal_retinal_apoptosis1.55669400
45MP0003698_abnormal_male_reproductive1.55463446
46MP0005387_immune_system_phenotype1.53751877
47MP0001790_abnormal_immune_system1.53751877
48MP0002452_abnormal_antigen_presenting1.53330156
49MP0000015_abnormal_ear_pigmentation1.52896716
50MP0005171_absent_coat_pigmentation1.52418333
51MP0001984_abnormal_olfaction1.51969204
52MP0003121_genomic_imprinting1.50556155
53MP0009333_abnormal_splenocyte_physiolog1.49986724
54MP0001800_abnormal_humoral_immune1.48347245
55MP0009697_abnormal_copulation1.44488169
56MP0001819_abnormal_immune_cell1.42713580
57MP0002420_abnormal_adaptive_immunity1.42412579
58MP0003436_decreased_susceptibility_to1.42251726
59MP0006054_spinal_hemorrhage1.41950414
60MP0003718_maternal_effect1.39839779
61MP0000685_abnormal_immune_system1.39012880
62MP0001346_abnormal_lacrimal_gland1.37795355
63MP0003011_delayed_dark_adaptation1.37787363
64MP0003656_abnormal_erythrocyte_physiolo1.37024366
65MP0004133_heterotaxia1.36891310
66MP0002282_abnormal_trachea_morphology1.35733318
67MP0006036_abnormal_mitochondrial_physio1.35035058
68MP0005253_abnormal_eye_physiology1.32443110
69MP0005075_abnormal_melanosome_morpholog1.31685185
70MP0004142_abnormal_muscle_tone1.27083846
71MP0001727_abnormal_embryo_implantation1.27062838
72MP0002736_abnormal_nociception_after1.24825307
73MP0002653_abnormal_ependyma_morphology1.23115881
74MP0000049_abnormal_middle_ear1.22236008
75MP0002751_abnormal_autonomic_nervous1.20737965
76MP0005389_reproductive_system_phenotype1.20615324
77MP0004742_abnormal_vestibular_system1.20122225
78MP0003119_abnormal_digestive_system1.19751745
79MP0010386_abnormal_urinary_bladder1.18919802
80MP0002233_abnormal_nose_morphology1.17343281
81MP0005310_abnormal_salivary_gland1.15501870
82MP0003806_abnormal_nucleotide_metabolis1.14405593
83MP0001119_abnormal_female_reproductive1.14116886
84MP0006035_abnormal_mitochondrial_morpho1.13202580
85MP0000647_abnormal_sebaceous_gland1.12895755
86MP0003890_abnormal_embryonic-extraembry1.12274860
87MP0002234_abnormal_pharynx_morphology1.10731055
88MP0003941_abnormal_skin_development1.09715548
89MP0008058_abnormal_DNA_repair1.09087268
90MP0001853_heart_inflammation1.09019108
91MP0000716_abnormal_immune_system1.06905576
92MP0003077_abnormal_cell_cycle1.05602572
93MP0000358_abnormal_cell_content/1.04765025
94MP0005646_abnormal_pituitary_gland1.04599387
95MP0005379_endocrine/exocrine_gland_phen1.03833290
96MP0000631_abnormal_neuroendocrine_gland1.03510032
97MP0010094_abnormal_chromosome_stability1.02586697
98MP0002398_abnormal_bone_marrow1.02382002
99MP0009046_muscle_twitch1.01809740
100MP0001533_abnormal_skeleton_physiology1.01804444
101MP0000778_abnormal_nervous_system1.01195378
102MP0003122_maternal_imprinting1.01063809
103MP0005174_abnormal_tail_pigmentation1.00824030
104MP0001286_abnormal_eye_development0.99873812
105MP0003693_abnormal_embryo_hatching0.99268324
106MP0002933_joint_inflammation0.98104309
107MP0003195_calcinosis0.97178080
108MP0002132_abnormal_respiratory_system0.97143426
109MP0002396_abnormal_hematopoietic_system0.96242734
110MP0005551_abnormal_eye_electrophysiolog0.95980769
111MP0003567_abnormal_fetal_cardiomyocyte0.94511112
112MP0002405_respiratory_system_inflammati0.92528274
113MP0004215_abnormal_myocardial_fiber0.91325284
114MP0002084_abnormal_developmental_patter0.91271672
115MP0005164_abnormal_response_to0.91185249
116MP0004147_increased_porphyrin_level0.90910375
117MP0002161_abnormal_fertility/fecundity0.90733355
118MP0002429_abnormal_blood_cell0.90668000
119MP0003938_abnormal_ear_development0.90377062
120MP0005645_abnormal_hypothalamus_physiol0.89559843
121MP0002295_abnormal_pulmonary_circulatio0.89505889
122MP0002090_abnormal_vision0.89493771
123MP0005409_darkened_coat_color0.89257395
124MP0005058_abnormal_lysosome_morphology0.88931297
125MP0002735_abnormal_chemical_nociception0.87415184
126MP0003786_premature_aging0.86183131
127MP0002095_abnormal_skin_pigmentation0.85504706
128MP0008469_abnormal_protein_level0.83968154
129MP0005391_vision/eye_phenotype0.83905531
130MP0000516_abnormal_urinary_system0.83796028
131MP0005367_renal/urinary_system_phenotyp0.83796028
132MP0001845_abnormal_inflammatory_respons0.83785187
133MP0001697_abnormal_embryo_size0.83158751
134MP0001188_hyperpigmentation0.82534176
135MP0000689_abnormal_spleen_morphology0.82426913
136MP0000537_abnormal_urethra_morphology0.82320894
137MP0008004_abnormal_stomach_pH0.82008992
138MP0001764_abnormal_homeostasis0.81605318
139MP0002938_white_spotting0.81384958
140MP0005451_abnormal_body_composition0.81303853
141MP0001968_abnormal_touch/_nociception0.80273837
142MP0002638_abnormal_pupillary_reflex0.79966259
143MP0005464_abnormal_platelet_physiology0.78247260
144MP0003315_abnormal_perineum_morphology0.78058102
145MP0000343_altered_response_to0.77711398
146MP0005084_abnormal_gallbladder_morpholo0.77453248
147MP0002085_abnormal_embryonic_tissue0.76611084
148MP0002722_abnormal_immune_system0.76574897
149MP0002332_abnormal_exercise_endurance0.76516710
150MP0003448_altered_tumor_morphology0.74548430
151MP0002006_tumorigenesis0.74408286
152MP0000858_altered_metastatic_potential0.73754590
153MP0001851_eye_inflammation0.72487882
154MP0008877_abnormal_DNA_methylation0.72115602
155MP0001177_atelectasis0.71980267
156MP0003755_abnormal_palate_morphology0.71734614
157MP0001486_abnormal_startle_reflex0.71723234
158MP0001299_abnormal_eye_distance/0.71255512
159MP0001440_abnormal_grooming_behavior0.70293989
160MP0005187_abnormal_penis_morphology0.69602456
161MP0002697_abnormal_eye_size0.69532083
162MP0001730_embryonic_growth_arrest0.69490572
163MP0008007_abnormal_cellular_replicative0.68514756
164MP0001324_abnormal_eye_pigmentation0.66742135
165MP0005380_embryogenesis_phenotype0.65754304
166MP0001672_abnormal_embryogenesis/_devel0.65754304
167MP0001485_abnormal_pinna_reflex0.65373841
168MP0003385_abnormal_body_wall0.65127966
169MP0001542_abnormal_bone_strength0.61865304

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.84476476
2Mitochondrial inheritance (HP:0001427)5.26106504
3Abnormal mitochondria in muscle tissue (HP:0008316)5.21367442
4Increased hepatocellular lipid droplets (HP:0006565)4.98960528
5Progressive macrocephaly (HP:0004481)4.74165331
6Acute encephalopathy (HP:0006846)4.58129277
7Abnormality of glycolysis (HP:0004366)4.54623706
8Increased serum pyruvate (HP:0003542)4.54623706
9Renal Fanconi syndrome (HP:0001994)4.46582774
10Lipid accumulation in hepatocytes (HP:0006561)4.37841696
11Increased CSF lactate (HP:0002490)4.37619680
12Parakeratosis (HP:0001036)4.26340831
13Hepatocellular necrosis (HP:0001404)4.21017943
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.00583592
153-Methylglutaconic aciduria (HP:0003535)3.94654727
16Exertional dyspnea (HP:0002875)3.90159405
17Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.87391199
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.75777500
19Abnormality of cells of the erythroid lineage (HP:0012130)3.53142867
20Hepatic necrosis (HP:0002605)3.49103529
21Abnormality of the anterior horn cell (HP:0006802)3.46330551
22Degeneration of anterior horn cells (HP:0002398)3.46330551
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.31563876
24Decreased activity of mitochondrial respiratory chain (HP:0008972)3.31563876
25Leukodystrophy (HP:0002415)3.28992848
26Increased intramyocellular lipid droplets (HP:0012240)3.28333960
27Exercise intolerance (HP:0003546)3.26099714
28Cerebral hypomyelination (HP:0006808)3.17830485
29Abnormal number of erythroid precursors (HP:0012131)3.13016643
30Respiratory failure (HP:0002878)3.10593931
31Increased serum lactate (HP:0002151)3.07349488
32Abnormality of the labia minora (HP:0012880)2.95918068
33Recurrent abscess formation (HP:0002722)2.95200843
34Reticulocytopenia (HP:0001896)2.87774474
35Cerebral edema (HP:0002181)2.83945823
36Abnormality of renal resorption (HP:0011038)2.76454394
37Optic disc pallor (HP:0000543)2.74457812
38Colon cancer (HP:0003003)2.73569329
39Recurrent bacterial skin infections (HP:0005406)2.72039584
40Gonadotropin excess (HP:0000837)2.69697941
41Lactic acidosis (HP:0003128)2.67743839
42True hermaphroditism (HP:0010459)2.66698449
43Pancreatic fibrosis (HP:0100732)2.65214154
44Atrophy/Degeneration involving motor neurons (HP:0007373)2.64674982
45Increased muscle lipid content (HP:0009058)2.62632408
46Respiratory difficulties (HP:0002880)2.62104624
47Hypothermia (HP:0002045)2.58601743
48Congenital ichthyosiform erythroderma (HP:0007431)2.55937431
49Increased IgM level (HP:0003496)2.54338703
50Pancreatic cysts (HP:0001737)2.53217585
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.48820368
52Gait imbalance (HP:0002141)2.47496469
53Macrocytic anemia (HP:0001972)2.44106358
54Abnormal protein glycosylation (HP:0012346)2.38757470
55Abnormal glycosylation (HP:0012345)2.38757470
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.38757470
57Abnormal protein N-linked glycosylation (HP:0012347)2.38757470
58Hepatosplenomegaly (HP:0001433)2.36842773
59Nephrogenic diabetes insipidus (HP:0009806)2.34481329
60Meckel diverticulum (HP:0002245)2.33816935
61Amniotic constriction ring (HP:0009775)2.33649787
62Abnormality of placental membranes (HP:0011409)2.33649787
63Abnormal lung lobation (HP:0002101)2.32606462
64Microvesicular hepatic steatosis (HP:0001414)2.31788362
65Abnormality of midbrain morphology (HP:0002418)2.26586900
66Molar tooth sign on MRI (HP:0002419)2.26586900
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.25568784
68Pallor (HP:0000980)2.25547909
69Hyperglycinemia (HP:0002154)2.24472892
70Abnormality of alanine metabolism (HP:0010916)2.22828967
71Hyperalaninemia (HP:0003348)2.22828967
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22828967
73Short tibia (HP:0005736)2.22241065
74Poor head control (HP:0002421)2.19976188
75Abnormality of the ileum (HP:0001549)2.18749900
76Methylmalonic acidemia (HP:0002912)2.16054550
77Neuroendocrine neoplasm (HP:0100634)2.15825822
78Aplastic anemia (HP:0001915)2.15404027
79Nephronophthisis (HP:0000090)2.15213264
80Tubulointerstitial nephritis (HP:0001970)2.14965083
81Volvulus (HP:0002580)2.12314719
82Abnormality of macrophages (HP:0004311)2.11391659
83X-linked dominant inheritance (HP:0001423)2.10610656
84Stenosis of the external auditory canal (HP:0000402)2.08596168
85Genital tract atresia (HP:0001827)2.08482874
86Stomatitis (HP:0010280)2.07289842
87Abnormality of chromosome stability (HP:0003220)2.06237660
88Abnormality of serum amino acid levels (HP:0003112)2.04145074
89Shoulder girdle muscle weakness (HP:0003547)2.03718750
90Obstructive lung disease (HP:0006536)2.02865895
91Chronic obstructive pulmonary disease (HP:0006510)2.02865895
92Sclerocornea (HP:0000647)2.01848445
93Duodenal stenosis (HP:0100867)2.01285854
94Small intestinal stenosis (HP:0012848)2.01285854
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00930888
96Elevated erythrocyte sedimentation rate (HP:0003565)2.00192472
97Supernumerary spleens (HP:0009799)2.00144810
98Oligodactyly (hands) (HP:0001180)1.99901794
99Chromosomal breakage induced by crosslinking agents (HP:0003221)1.99191396
100Vaginal atresia (HP:0000148)1.99006351
101Sensory axonal neuropathy (HP:0003390)1.98534162
102Chromsome breakage (HP:0040012)1.97378758
103Glycosuria (HP:0003076)1.96670869
104Abnormality of urine glucose concentration (HP:0011016)1.96670869
105Aplasia/Hypoplasia of the tongue (HP:0010295)1.96555929
106Preaxial hand polydactyly (HP:0001177)1.94907619
107Aplasia/Hypoplasia of the tibia (HP:0005772)1.93769215
108Median cleft lip (HP:0000161)1.93145065
109Abnormal hemoglobin (HP:0011902)1.91686472
110Lethargy (HP:0001254)1.91332640
111Abnormal hair whorl (HP:0010721)1.90906843
112Eczematoid dermatitis (HP:0000976)1.90727490
113Irregular epiphyses (HP:0010582)1.90548154
114Hypoplastic pelvis (HP:0008839)1.89400819
115CNS demyelination (HP:0007305)1.89219415
116Cerebral hemorrhage (HP:0001342)1.87588891
117Abnormality of the preputium (HP:0100587)1.86881682
118Retinal dysplasia (HP:0007973)1.86199833
119Vacuolated lymphocytes (HP:0001922)1.84484113
120Hyperphosphaturia (HP:0003109)1.84269332
121Pheochromocytoma (HP:0002666)1.83567006
122Recurrent skin infections (HP:0001581)1.83102248
123Prolonged neonatal jaundice (HP:0006579)1.82360822
124CNS hypomyelination (HP:0003429)1.82253553
125Medial flaring of the eyebrow (HP:0010747)1.82112190
126Abnormality of the duodenum (HP:0002246)1.82067961
127Methylmalonic aciduria (HP:0012120)1.81394912
128Autoamputation (HP:0001218)1.81122350
129Degeneration of the lateral corticospinal tracts (HP:0002314)1.80435138
130Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80435138
131Patchy hypopigmentation of hair (HP:0011365)1.80367960
132Rough bone trabeculation (HP:0100670)1.77743549
133Hypokinesia (HP:0002375)1.76544704
134Postaxial hand polydactyly (HP:0001162)1.76510270
135Pendular nystagmus (HP:0012043)1.76287597
136Postaxial foot polydactyly (HP:0001830)1.75678472
137Abnormal trabecular bone morphology (HP:0100671)1.75171651
138Anencephaly (HP:0002323)1.74353440
139Abnormality of methionine metabolism (HP:0010901)1.72635390
140Abnormal pupillary function (HP:0007686)1.72485158
141Renal tubular dysfunction (HP:0000124)1.71576260
142Abnormality of the renal medulla (HP:0100957)1.71551999
143Xerostomia (HP:0000217)1.71334142
144Oculomotor apraxia (HP:0000657)1.71121931
145Glossoptosis (HP:0000162)1.70970067
146Postnatal microcephaly (HP:0005484)1.68837094
147Aplasia/hypoplasia of the uterus (HP:0008684)1.68544116
148Triphalangeal thumb (HP:0001199)1.68314023
149Decreased testicular size (HP:0008734)1.68311315
150Recurrent pneumonia (HP:0006532)1.67812605
151Male pseudohermaphroditism (HP:0000037)1.67040294
152Ependymoma (HP:0002888)1.65397465
153Cleft eyelid (HP:0000625)1.62280454
154Petechiae (HP:0000967)1.61732251
155Spastic paraparesis (HP:0002313)1.60468634
156Pancytopenia (HP:0001876)1.59558099
157Emotional lability (HP:0000712)1.59342547
158Septate vagina (HP:0001153)1.57833233
159Purpura (HP:0000979)1.57833197
160Agnosia (HP:0010524)1.55683907
161Mediastinal lymphadenopathy (HP:0100721)1.54814093
162Abnormal urine phosphate concentration (HP:0012599)1.53787553
163Breast hypoplasia (HP:0003187)1.53306821
164Type I transferrin isoform profile (HP:0003642)1.52035465
165Congenital primary aphakia (HP:0007707)1.51919980

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.37798006
2EIF2AK13.36137685
3MST42.93945863
4NME22.91163223
5BUB12.84508306
6VRK22.83899463
7STK162.81397483
8TRIM282.57788046
9STK392.54322930
10MAP3K122.31545187
11NEK12.29551199
12BCR2.20260503
13WNK32.18383834
14ZAK2.06811434
15TTK1.94174535
16VRK11.90975899
17CASK1.90565592
18PDK21.90139544
19ARAF1.83890469
20EIF2AK31.83526708
21OXSR11.82742234
22PIM21.80454060
23NME11.78480090
24LIMK11.77996118
25MAPKAPK51.77307775
26BMPR1B1.70593433
27MAP4K21.66495681
28MAP3K41.62129400
29IRAK41.57657398
30BCKDK1.53903367
31TLK11.51660939
32EPHA41.48998676
33PLK11.46581275
34TESK21.37375834
35SRPK11.36117079
36MAP2K71.34711404
37TXK1.29690065
38GRK71.28162733
39DYRK21.27758784
40MYLK1.24435787
41CLK11.22885912
42WEE11.22806266
43ADRBK21.22542928
44TSSK61.18770237
45MKNK21.18679836
46BRSK11.15156186
47CDK191.14794199
48ABL21.14622329
49CSNK1G21.11388071
50BMPR21.10512221
51MINK11.06837485
52BLK1.05051409
53CSNK1A1L1.04206888
54STK38L1.04068463
55MAP3K141.02048875
56RIPK40.98945033
57TESK10.97204616
58RPS6KA50.95600282
59EPHB10.95557014
60PINK10.93712142
61MKNK10.92707549
62PLK20.90784193
63FGR0.89431251
64CSNK1G30.88518617
65CDC70.88472549
66EIF2AK20.86627361
67SIK30.86262188
68ATR0.86079742
69PLK40.84794142
70GRK10.84253462
71IRAK30.83116727
72TNIK0.82877334
73MAPK130.81293103
74WNK40.80258816
75BRSK20.80043111
76RPS6KA40.79283212
77CAMK2B0.78646815
78AURKB0.77973495
79KIT0.77648590
80ACVR1B0.71775969
81TBK10.71012565
82TIE10.70937901
83DYRK30.70799647
84TYK20.68924460
85MUSK0.68024670
86PKN10.66127313
87IKBKB0.64021989
88SYK0.63753554
89TEC0.62488778
90PIK3CG0.61001443
91TAF10.60899040
92FRK0.60794222
93LYN0.60723473
94YES10.60274897
95CHEK20.58866388
96ATM0.58810930
97PAK40.58725549
98BRAF0.58213990
99ADRBK10.57250879
100DAPK10.57187666
101LCK0.56868452
102PRKCG0.56791347
103IKBKE0.56160441
104ERBB30.56123157
105CCNB10.54430323
106CDK140.53453071
107CDK180.52267976
108INSRR0.52139077
109CSNK2A10.51924658
110STK40.51517425
111NUAK10.51286968
112NEK60.50686666
113AURKA0.50138914
114PLK30.49028142
115MAP4K10.48889583
116CAMK2D0.48617407
117EPHB20.48448364
118ROCK20.48233287
119UHMK10.47997095
120PNCK0.47197123
121CDK150.46789579
122CHEK10.46078010
123MOS0.46027685
124PASK0.45663876
125PAK10.44849165
126PRKCE0.44634703
127CDK11A0.44447664
128PRKCQ0.43527180
129KDR0.43197091
130MET0.42378293
131ILK0.42330889
132CSNK2A20.40824051
133CAMK2G0.40473131
134CSNK1G10.39920620
135MST1R0.39436802
136PRKCD0.38957571
137NEK20.38389670
138MAP3K50.36709570
139CAMK2A0.34961843
140PRKCI0.34351415
141CSNK1E0.31991592
142PAK30.31184237
143ERBB40.30645240
144CDK80.29538992

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.76619046
2Oxidative phosphorylation_Homo sapiens_hsa001904.42984736
3Ribosome_Homo sapiens_hsa030104.12534083
4Parkinsons disease_Homo sapiens_hsa050123.74013147
5RNA polymerase_Homo sapiens_hsa030203.19626159
6Protein export_Homo sapiens_hsa030603.17546091
7Alzheimers disease_Homo sapiens_hsa050102.72132112
8Huntingtons disease_Homo sapiens_hsa050162.60311741
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.29638436
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.28022878
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.14209755
12DNA replication_Homo sapiens_hsa030301.93026924
13Propanoate metabolism_Homo sapiens_hsa006401.90024034
14Pyrimidine metabolism_Homo sapiens_hsa002401.77575812
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73715129
16Mismatch repair_Homo sapiens_hsa034301.72985567
17Graft-versus-host disease_Homo sapiens_hsa053321.70551583
18Homologous recombination_Homo sapiens_hsa034401.66165356
19Steroid biosynthesis_Homo sapiens_hsa001001.65086291
20Basal transcription factors_Homo sapiens_hsa030221.63534471
21Collecting duct acid secretion_Homo sapiens_hsa049661.61911601
22Nucleotide excision repair_Homo sapiens_hsa034201.59590266
23Rheumatoid arthritis_Homo sapiens_hsa053231.58553947
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57933160
25Allograft rejection_Homo sapiens_hsa053301.54653994
26Fatty acid elongation_Homo sapiens_hsa000621.53961662
27Pyruvate metabolism_Homo sapiens_hsa006201.52213978
28Spliceosome_Homo sapiens_hsa030401.49246637
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40240424
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39998326
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36254804
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.35554119
33Non-homologous end-joining_Homo sapiens_hsa034501.35485604
34Vibrio cholerae infection_Homo sapiens_hsa051101.30219613
35One carbon pool by folate_Homo sapiens_hsa006701.22186451
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21394141
37Autoimmune thyroid disease_Homo sapiens_hsa053201.20421953
38Phagosome_Homo sapiens_hsa041451.16799561
39Ether lipid metabolism_Homo sapiens_hsa005651.15754312
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15276622
41Selenocompound metabolism_Homo sapiens_hsa004501.13399299
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08902459
43Oocyte meiosis_Homo sapiens_hsa041141.06880331
44Butanoate metabolism_Homo sapiens_hsa006501.05587026
45RNA degradation_Homo sapiens_hsa030181.04557839
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03849996
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02497538
48Cardiac muscle contraction_Homo sapiens_hsa042601.02411968
49Purine metabolism_Homo sapiens_hsa002301.00372195
50Asthma_Homo sapiens_hsa053100.97435537
51RNA transport_Homo sapiens_hsa030130.96094936
52Base excision repair_Homo sapiens_hsa034100.94066965
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92655676
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90920195
55Sulfur metabolism_Homo sapiens_hsa009200.87401354
56Epstein-Barr virus infection_Homo sapiens_hsa051690.87320102
57Sulfur relay system_Homo sapiens_hsa041220.87297084
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86647896
59Carbon metabolism_Homo sapiens_hsa012000.85811495
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.84808451
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83571116
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83295293
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83282692
64Sphingolipid metabolism_Homo sapiens_hsa006000.82923169
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82522888
66Type I diabetes mellitus_Homo sapiens_hsa049400.78803939
67Legionellosis_Homo sapiens_hsa051340.78164257
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77964927
69Primary immunodeficiency_Homo sapiens_hsa053400.77919513
70Malaria_Homo sapiens_hsa051440.76887636
71Biosynthesis of amino acids_Homo sapiens_hsa012300.76476814
72Fanconi anemia pathway_Homo sapiens_hsa034600.75102341
73Arachidonic acid metabolism_Homo sapiens_hsa005900.73839261
74Glutathione metabolism_Homo sapiens_hsa004800.70059309
75Antigen processing and presentation_Homo sapiens_hsa046120.69945736
76Pertussis_Homo sapiens_hsa051330.69025394
77Folate biosynthesis_Homo sapiens_hsa007900.67929680
78beta-Alanine metabolism_Homo sapiens_hsa004100.66741222
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66270191
80Hematopoietic cell lineage_Homo sapiens_hsa046400.66146142
81N-Glycan biosynthesis_Homo sapiens_hsa005100.65213718
82Leishmaniasis_Homo sapiens_hsa051400.65041234
83Shigellosis_Homo sapiens_hsa051310.58144574
84Fatty acid metabolism_Homo sapiens_hsa012120.58062641
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57786092
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56403262
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.55932173
88Measles_Homo sapiens_hsa051620.55622631
89Metabolic pathways_Homo sapiens_hsa011000.55346433
90Cell cycle_Homo sapiens_hsa041100.50858966
91Nicotine addiction_Homo sapiens_hsa050330.50299063
92Tryptophan metabolism_Homo sapiens_hsa003800.49123305
93Tuberculosis_Homo sapiens_hsa051520.48681260
94Linoleic acid metabolism_Homo sapiens_hsa005910.47682817
95African trypanosomiasis_Homo sapiens_hsa051430.47158964
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45297213
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45063577
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43232707
99Arginine and proline metabolism_Homo sapiens_hsa003300.42831114
100Histidine metabolism_Homo sapiens_hsa003400.41191385
101Herpes simplex infection_Homo sapiens_hsa051680.40815401
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40713644
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40070397
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38465158
105Other glycan degradation_Homo sapiens_hsa005110.38328613
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38276150
107Chemical carcinogenesis_Homo sapiens_hsa052040.37690815
108Retinol metabolism_Homo sapiens_hsa008300.37313273
109Salmonella infection_Homo sapiens_hsa051320.37249315
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36680940
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.36655532
112TGF-beta signaling pathway_Homo sapiens_hsa043500.36249441
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36095921
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36018193
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36017558
116Tyrosine metabolism_Homo sapiens_hsa003500.33457873
117Serotonergic synapse_Homo sapiens_hsa047260.33357330
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.33240227
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32888397
120Hedgehog signaling pathway_Homo sapiens_hsa043400.31225338
121Lysosome_Homo sapiens_hsa041420.30873557
122Systemic lupus erythematosus_Homo sapiens_hsa053220.30250835
123Nitrogen metabolism_Homo sapiens_hsa009100.29599732
124Fatty acid degradation_Homo sapiens_hsa000710.28966273
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28834038
126Synaptic vesicle cycle_Homo sapiens_hsa047210.27771663
127Regulation of autophagy_Homo sapiens_hsa041400.26857298
128Viral myocarditis_Homo sapiens_hsa054160.26668150
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25446107
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24747329
131Caffeine metabolism_Homo sapiens_hsa002320.24065882
132Circadian rhythm_Homo sapiens_hsa047100.23520313
133Influenza A_Homo sapiens_hsa051640.22908584
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22722879
135Basal cell carcinoma_Homo sapiens_hsa052170.22271454
136Hippo signaling pathway_Homo sapiens_hsa043900.18418092
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17756813
138p53 signaling pathway_Homo sapiens_hsa041150.17745748
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.16899571
140Apoptosis_Homo sapiens_hsa042100.14462729
141Phenylalanine metabolism_Homo sapiens_hsa003600.13896379
142Phototransduction_Homo sapiens_hsa047440.13582170
143Alcoholism_Homo sapiens_hsa050340.12430021
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11200991
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10983552
146Vitamin B6 metabolism_Homo sapiens_hsa007500.09338645
147mRNA surveillance pathway_Homo sapiens_hsa030150.08838574
148Peroxisome_Homo sapiens_hsa041460.06934235

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