PSMD10P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)5.25748286
2negative regulation of translation, ncRNA-mediated (GO:0040033)4.91447215
3regulation of translation, ncRNA-mediated (GO:0045974)4.91447215
4negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.91447215
5mitotic sister chromatid cohesion (GO:0007064)4.85607371
6nuclear pore complex assembly (GO:0051292)4.75340182
7histone H3-K36 demethylation (GO:0070544)4.64116149
8monoubiquitinated protein deubiquitination (GO:0035520)4.60992251
9labyrinthine layer development (GO:0060711)4.52568161
10histone H3-K4 trimethylation (GO:0080182)4.51095629
11histone H3-K9 methylation (GO:0051567)4.42872191
12histone H3-K9 modification (GO:0061647)4.29219201
13phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.20338127
14cellular response to ethanol (GO:0071361)4.00659335
15nuclear pore organization (GO:0006999)3.99151989
16peptidyl-lysine trimethylation (GO:0018023)3.89909905
17negative regulation of neurotransmitter secretion (GO:0046929)3.80848399
18positive regulation of gamma-delta T cell activation (GO:0046645)3.79836822
19histone demethylation (GO:0016577)3.64820148
20regulation of B cell receptor signaling pathway (GO:0050855)3.58039275
21snRNA transcription (GO:0009301)3.56350398
22positive regulation of granulocyte differentiation (GO:0030854)3.52972698
23peptidyl-lysine methylation (GO:0018022)3.48419054
24regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.48127655
25positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.48127655
26B cell receptor signaling pathway (GO:0050853)3.46834786
27histone lysine methylation (GO:0034968)3.45505533
28negative regulation of DNA repair (GO:0045738)3.42336716
29positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.30999003
30regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.30999003
31pore complex assembly (GO:0046931)3.29575856
32neural tube formation (GO:0001841)3.27036095
33positive regulation of developmental pigmentation (GO:0048087)3.22233589
34regulation of histone H3-K9 methylation (GO:0051570)3.20595950
35protein K48-linked deubiquitination (GO:0071108)3.17610361
36protein dealkylation (GO:0008214)3.17075335
37protein demethylation (GO:0006482)3.17075335
38histone lysine demethylation (GO:0070076)3.13094253
39dosage compensation (GO:0007549)3.09965643
40positive regulation of mRNA processing (GO:0050685)3.07323792
41establishment of protein localization to Golgi (GO:0072600)3.06864715
42positive T cell selection (GO:0043368)3.05302094
43histone H3-K4 methylation (GO:0051568)3.04502696
44hepatocyte apoptotic process (GO:0097284)3.04484470
45N-terminal protein amino acid acetylation (GO:0006474)3.04237349
46pre-miRNA processing (GO:0031054)3.02040122
47protein K11-linked deubiquitination (GO:0035871)2.99925110
48regulation of Rac protein signal transduction (GO:0035020)2.99739099
49negative regulation of B cell proliferation (GO:0030889)2.99703937
50regulation of RNA export from nucleus (GO:0046831)2.98583482
51peptidyl-lysine dimethylation (GO:0018027)2.98581057
52definitive hemopoiesis (GO:0060216)2.97380076
53negative regulation of neurotransmitter transport (GO:0051589)2.96726090
54histone mRNA catabolic process (GO:0071044)2.95941598
55toxin transport (GO:1901998)2.95722735
56microtubule anchoring (GO:0034453)2.94670028
57positive regulation of mRNA 3-end processing (GO:0031442)2.94501915
58regulation of histone H3-K27 methylation (GO:0061085)2.92384942
59regulation of establishment of cell polarity (GO:2000114)2.91342665
60regulation of gamma-delta T cell differentiation (GO:0045586)2.89891964
61rRNA catabolic process (GO:0016075)2.89512379
62lipid translocation (GO:0034204)2.86358807
63phospholipid translocation (GO:0045332)2.86358807
64regulation of pigment cell differentiation (GO:0050932)2.85551919
65histone H3-K9 demethylation (GO:0033169)2.84970846
66negative regulation of T-helper cell differentiation (GO:0045623)2.84065799
67negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.84065799
68positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.76974876
69regulation of chromatin silencing (GO:0031935)2.76421470
70carnitine transmembrane transport (GO:1902603)2.75092637
71positive regulation of mRNA catabolic process (GO:0061014)2.74986717
72regulation of gamma-delta T cell activation (GO:0046643)2.74084590
73positive regulation of mRNA metabolic process (GO:1903313)2.71404614
74negative T cell selection (GO:0043383)2.70492426
75negative regulation of cell cycle G2/M phase transition (GO:1902750)2.66577487
76negative thymic T cell selection (GO:0045060)2.65953486
77determination of adult lifespan (GO:0008340)2.65344253
78regulation of mRNA catabolic process (GO:0061013)2.64091372
79interkinetic nuclear migration (GO:0022027)2.60387022
80pericardium development (GO:0060039)2.60151748
81protein targeting to lysosome (GO:0006622)2.58375656
82establishment of protein localization to vacuole (GO:0072666)2.58375656
83protein targeting to vacuole (GO:0006623)2.58375656
84histone methylation (GO:0016571)2.57259106
85sister chromatid cohesion (GO:0007062)2.57022776
86regulation of mRNA 3-end processing (GO:0031440)2.56208858
87ventricular septum morphogenesis (GO:0060412)2.56038531
88positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.55985631
89regulation of necroptotic process (GO:0060544)2.55218264
90carnitine transport (GO:0015879)2.54450156
91amino-acid betaine transport (GO:0015838)2.54450156
92nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.52696636
93V(D)J recombination (GO:0033151)2.52374144
94microtubule nucleation (GO:0007020)2.51840798
95replicative senescence (GO:0090399)2.51064930
96retrograde transport, vesicle recycling within Golgi (GO:0000301)2.50648426
97protein K63-linked deubiquitination (GO:0070536)2.50027280
98histone-serine phosphorylation (GO:0035404)2.48809376
99embryonic process involved in female pregnancy (GO:0060136)2.48598914
100regulation of nucleobase-containing compound transport (GO:0032239)2.47241575

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.68653576
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.33396662
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.03499751
4E2F7_22180533_ChIP-Seq_HELA_Human2.97273859
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.85352139
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.77138226
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.68788490
8GATA1_22025678_ChIP-Seq_K562_Human2.64378768
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.41670659
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39586565
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.08556446
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.04318691
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01052724
14IGF1R_20145208_ChIP-Seq_DFB_Human1.94272683
15RUNX_20019798_ChIP-Seq_JUKART_Human1.92401618
16TAF15_26573619_Chip-Seq_HEK293_Human1.90479743
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88460570
18MYB_26560356_Chip-Seq_TH2_Human1.81061937
19FOXM1_23109430_ChIP-Seq_U2OS_Human1.76414965
20SCL_19346495_ChIP-Seq_HPC-7_Human1.76387311
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76358782
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75128444
23EWS_26573619_Chip-Seq_HEK293_Human1.74134653
24AHR_22903824_ChIP-Seq_MCF-7_Human1.72198928
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71343040
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69902350
27TP53_16413492_ChIP-PET_HCT116_Human1.69463302
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.64538461
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63568175
30RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.59890905
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.57476753
32MYB_26560356_Chip-Seq_TH1_Human1.55573734
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54663309
34FUS_26573619_Chip-Seq_HEK293_Human1.51020312
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48584847
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.48226156
37STAT3_23295773_ChIP-Seq_U87_Human1.42140386
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.41798665
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.41481912
40ER_23166858_ChIP-Seq_MCF-7_Human1.38875207
41VDR_24787735_ChIP-Seq_THP-1_Human1.38681610
42CIITA_25753668_ChIP-Seq_RAJI_Human1.37567792
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37300349
44TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36869563
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36601253
46PKCTHETA_26484144_Chip-Seq_BREAST_Human1.36013281
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.34183345
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31738075
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31549183
50ZNF274_21170338_ChIP-Seq_K562_Hela1.30371363
51MYC_22102868_ChIP-Seq_BL_Human1.28392261
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26345526
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26018744
54GATA3_27048872_Chip-Seq_THYMUS_Human1.23775282
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23116863
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23023919
57CBP_20019798_ChIP-Seq_JUKART_Human1.23023919
58FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22979379
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22861119
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21668770
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19633045
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19335477
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18480233
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17946487
65GBX2_23144817_ChIP-Seq_PC3_Human1.17561351
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.16776254
67SMAD4_21799915_ChIP-Seq_A2780_Human1.16643072
68FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.16127863
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15940344
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.15511932
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14894295
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14894295
73P300_19829295_ChIP-Seq_ESCs_Human1.14058191
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.12065255
75CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08696744
76NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08599958
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.07829223
78SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07579552
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07051963
80TCF4_23295773_ChIP-Seq_U87_Human1.06058358
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.05912119
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03625463
83MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02535697
84GATA3_26560356_Chip-Seq_TH2_Human1.02369413
85CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01954763
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.00872450
87TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00142767
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99659322
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99190473
90AR_21572438_ChIP-Seq_LNCaP_Human0.98908872
91BCAT_22108803_ChIP-Seq_LS180_Human0.98039079
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96349292
93CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95753187
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95700087
95NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95274309
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93656655
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93006050
98RXR_22108803_ChIP-Seq_LS180_Human0.92374577
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92091791
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91739690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication7.59346267
2MP0000569_abnormal_digit_pigmentation5.82487560
3MP0002009_preneoplasia3.47112734
4MP0003787_abnormal_imprinting2.94713924
5MP0003763_abnormal_thymus_physiology2.66698952
6MP0000383_abnormal_hair_follicle2.46976846
7MP0001835_abnormal_antigen_presentation2.36091038
8MP0002396_abnormal_hematopoietic_system2.32510118
9MP0010307_abnormal_tumor_latency2.27885364
10MP0003890_abnormal_embryonic-extraembry2.24801399
11MP0005083_abnormal_biliary_tract2.18759725
12MP0002166_altered_tumor_susceptibility2.14846988
13MP0004381_abnormal_hair_follicle2.08973494
14MP0008877_abnormal_DNA_methylation2.06346574
15MP0010678_abnormal_skin_adnexa2.04291363
16MP0005076_abnormal_cell_differentiation1.97890082
17MP0004808_abnormal_hematopoietic_stem1.88968361
18MP0010352_gastrointestinal_tract_polyps1.86797209
19MP0009697_abnormal_copulation1.72875820
20MP0003077_abnormal_cell_cycle1.66721635
21MP0004484_altered_response_of1.62818535
22MP0000703_abnormal_thymus_morphology1.62485290
23MP0001800_abnormal_humoral_immune1.61024311
24MP0003828_pulmonary_edema1.59635621
25MP0010094_abnormal_chromosome_stability1.46404089
26MP0000427_abnormal_hair_cycle1.45373733
27MP0002398_abnormal_bone_marrow1.44424564
28MP0000689_abnormal_spleen_morphology1.39110157
29MP0005310_abnormal_salivary_gland1.38391079
30MP0001545_abnormal_hematopoietic_system1.37131368
31MP0005397_hematopoietic_system_phenotyp1.37131368
32MP0008961_abnormal_basal_metabolism1.36803955
33MP0008995_early_reproductive_senescence1.34917936
34MP0003656_abnormal_erythrocyte_physiolo1.32081160
35MP0002722_abnormal_immune_system1.31895989
36MP0008058_abnormal_DNA_repair1.30960501
37MP0002006_tumorigenesis1.26865340
38MP0000015_abnormal_ear_pigmentation1.26837299
39MP0000716_abnormal_immune_system1.17241549
40MP0005075_abnormal_melanosome_morpholog1.16084957
41MP0003045_fibrosis1.11764619
42MP0009115_abnormal_fat_cell1.11345232
43MP0001879_abnormal_lymphatic_vessel1.10762113
44MP0003091_abnormal_cell_migration1.10234479
45MP0002132_abnormal_respiratory_system1.09460839
46MP0003111_abnormal_nucleus_morphology1.05882196
47MP0003221_abnormal_cardiomyocyte_apopto1.05782580
48MP0004130_abnormal_muscle_cell1.05382328
49MP0003121_genomic_imprinting1.04827517
50MP0002420_abnormal_adaptive_immunity1.04592049
51MP0002088_abnormal_embryonic_growth/wei1.01773816
52MP0003786_premature_aging1.01517502
53MP0003984_embryonic_growth_retardation1.01452783
54MP0005266_abnormal_metabolism1.01216691
55MP0001819_abnormal_immune_cell1.01098784
56MP0002452_abnormal_antigen_presenting0.98154725
57MP0003724_increased_susceptibility_to0.97770430
58MP0003646_muscle_fatigue0.96396597
59MP0002405_respiratory_system_inflammati0.95834380
60MP0002723_abnormal_immune_serum0.94462796
61MP0002019_abnormal_tumor_incidence0.93968434
62MP0002429_abnormal_blood_cell0.92600259
63MP0005174_abnormal_tail_pigmentation0.91884432
64MP0004883_abnormal_blood_vessel0.91880190
65MP0002086_abnormal_extraembryonic_tissu0.91122222
66MP0002928_abnormal_bile_duct0.88574132
67MP0008007_abnormal_cellular_replicative0.88425638
68MP0001851_eye_inflammation0.86868227
69MP0009278_abnormal_bone_marrow0.86440238
70MP0000685_abnormal_immune_system0.85938707
71MP0004134_abnormal_chest_morphology0.85907042
72MP0004185_abnormal_adipocyte_glucose0.83453146
73MP0005621_abnormal_cell_physiology0.83354525
74MP0000516_abnormal_urinary_system0.82655751
75MP0005367_renal/urinary_system_phenotyp0.82655751
76MP0003567_abnormal_fetal_cardiomyocyte0.82426397
77MP0001661_extended_life_span0.82253736
78MP0000371_diluted_coat_color0.81530371
79MP0005380_embryogenesis_phenotype0.80979469
80MP0001672_abnormal_embryogenesis/_devel0.80979469
81MP0002332_abnormal_exercise_endurance0.79885805
82MP0001915_intracranial_hemorrhage0.79448006
83MP0003300_gastrointestinal_ulcer0.76643097
84MP0005000_abnormal_immune_tolerance0.76297454
85MP0000350_abnormal_cell_proliferation0.74363321
86MP0001873_stomach_inflammation0.74348391
87MP0005646_abnormal_pituitary_gland0.74318802
88MP0003943_abnormal_hepatobiliary_system0.71588737
89MP0010630_abnormal_cardiac_muscle0.69451568
90MP0003866_abnormal_defecation0.68933391
91MP0001697_abnormal_embryo_size0.67695443
92MP0003252_abnormal_bile_duct0.67172803
93MP0002168_other_aberrant_phenotype0.66304054
94MP0005187_abnormal_penis_morphology0.65924797
95MP0004197_abnormal_fetal_growth/weight/0.65502679
96MP0001784_abnormal_fluid_regulation0.65143533
97MP0003115_abnormal_respiratory_system0.62874237
98MP0005220_abnormal_exocrine_pancreas0.62830715
99MP0002925_abnormal_cardiovascular_devel0.61678078
100MP0005384_cellular_phenotype0.60263608

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.27015575
2Neonatal hypoglycemia (HP:0001998)3.96966195
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.60415183
4Genetic anticipation (HP:0003743)3.43652245
5Chromsome breakage (HP:0040012)3.37083556
6T lymphocytopenia (HP:0005403)3.34527961
7Acute myeloid leukemia (HP:0004808)3.12527218
8Abnormality of T cell number (HP:0011839)3.01218721
9Narrow palate (HP:0000189)2.99312693
10Spontaneous hematomas (HP:0007420)2.98630574
11Overgrowth (HP:0001548)2.97045116
12Heterotopia (HP:0002282)2.95025756
13Papillary thyroid carcinoma (HP:0002895)2.90748069
14Amyotrophic lateral sclerosis (HP:0007354)2.90435917
15Chronic hepatic failure (HP:0100626)2.87349826
16Truncal obesity (HP:0001956)2.87226722
17Abnormality of the nasal septum (HP:0000419)2.86683744
18Neoplasm of the adrenal cortex (HP:0100641)2.74062740
19Colitis (HP:0002583)2.74019935
20Fair hair (HP:0002286)2.70313280
21Abnormality of chromosome stability (HP:0003220)2.68839095
22Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.60427800
23Neoplasm of the tracheobronchial system (HP:0100552)2.57587020
24Acute lymphatic leukemia (HP:0006721)2.51699270
25IgM deficiency (HP:0002850)2.50327093
26Partial agenesis of the corpus callosum (HP:0001338)2.48210088
27Sandal gap (HP:0001852)2.46590957
28Dysmetric saccades (HP:0000641)2.44714922
29Prominent nose (HP:0000448)2.43016557
30Hematochezia (HP:0002573)2.40958171
31Protruding tongue (HP:0010808)2.39493668
32Gaze-evoked nystagmus (HP:0000640)2.39216085
33Progressive cerebellar ataxia (HP:0002073)2.36090240
34Macroorchidism (HP:0000053)2.35960639
35Abnormality of the lower motor neuron (HP:0002366)2.35637555
36Volvulus (HP:0002580)2.35046703
37IgA deficiency (HP:0002720)2.34066865
38Deep philtrum (HP:0002002)2.30284364
39Recurrent viral infections (HP:0004429)2.27018780
40Curly hair (HP:0002212)2.25836560
41Thyroiditis (HP:0100646)2.25719319
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.25552810
43Thyroid carcinoma (HP:0002890)2.23755692
44Subacute progressive viral hepatitis (HP:0006572)2.23728285
45Inflammation of the large intestine (HP:0002037)2.20212109
46Clubbing of toes (HP:0100760)2.17992376
47Long eyelashes (HP:0000527)2.17866242
48Viral hepatitis (HP:0006562)2.17437925
49Autoimmune hemolytic anemia (HP:0001890)2.16014313
50Thick eyebrow (HP:0000574)2.15651110
51Febrile seizures (HP:0002373)2.12974765
52Generalized hypopigmentation of hair (HP:0011358)2.12217854
53Lower limb hyperreflexia (HP:0002395)2.10958817
54Pseudobulbar signs (HP:0002200)2.06054502
55Alveolar cell carcinoma (HP:0006519)2.05595374
56Submucous cleft hard palate (HP:0000176)2.02540036
57Recurrent fungal infections (HP:0002841)2.02509942
58Stomach cancer (HP:0012126)2.00390247
59Aqueductal stenosis (HP:0002410)1.98303550
60Sparse lateral eyebrow (HP:0005338)1.97674591
61Panhypogammaglobulinemia (HP:0003139)1.97562694
62Recurrent bacterial skin infections (HP:0005406)1.97176367
63Glioma (HP:0009733)1.96132491
64Basal cell carcinoma (HP:0002671)1.95009758
65Urinary bladder sphincter dysfunction (HP:0002839)1.94954147
66Gastrointestinal inflammation (HP:0004386)1.93236494
67Hypoplastic labia majora (HP:0000059)1.92331795
68Rhabdomyosarcoma (HP:0002859)1.90801072
69Abnormality of the labia majora (HP:0012881)1.90796737
70Nephroblastoma (Wilms tumor) (HP:0002667)1.90792902
71Hamartoma (HP:0010566)1.89789391
72Embryonal renal neoplasm (HP:0011794)1.88827512
73Diastasis recti (HP:0001540)1.88416444
74Abnormality of T cells (HP:0002843)1.88011055
75Recurrent cutaneous fungal infections (HP:0011370)1.87967066
76Chronic mucocutaneous candidiasis (HP:0002728)1.87967066
77Abnormality of the astrocytes (HP:0100707)1.86600427
78Astrocytoma (HP:0009592)1.86600427
79Vitreoretinal degeneration (HP:0000655)1.83606105
80Widely spaced teeth (HP:0000687)1.83416713
81Cystic hygroma (HP:0000476)1.82304012
82Cafe-au-lait spot (HP:0000957)1.76972779
83Tetraparesis (HP:0002273)1.74317397
84Lip pit (HP:0100267)1.72846185
85Recurrent bronchitis (HP:0002837)1.71448259
86Increased neuronal autofluorescent lipopigment (HP:0002074)1.70774512
87Hypoplasia of the thymus (HP:0000778)1.70635978
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.69805547
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.69526930
90Neurodegeneration (HP:0002180)1.68650210
91Polycythemia (HP:0001901)1.68162645
92Depressed nasal tip (HP:0000437)1.68145583
93Slow saccadic eye movements (HP:0000514)1.66992525
94Neoplasm of striated muscle (HP:0009728)1.66417803
95Increased number of teeth (HP:0011069)1.63664480
96Hypopigmentation of the fundus (HP:0007894)1.63632755
97Clumsiness (HP:0002312)1.63517268
98Abnormality of chromosome segregation (HP:0002916)1.62684333
99Poor coordination (HP:0002370)1.61852635
100Obsessive-compulsive behavior (HP:0000722)1.61578569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.50828934
2CDK124.23780667
3AKT33.25491059
4BRD43.17741085
5BRSK23.16011421
6PBK2.99090933
7TAOK32.85843297
8MAP3K102.18800255
9SGK22.01734909
10MKNK21.97557389
11CAMK1D1.89603773
12CAMK1G1.73019978
13MAP3K61.65249914
14NLK1.64561734
15MELK1.62007279
16FGFR21.61725571
17SCYL21.55909891
18BMPR21.53077363
19ZAK1.45277528
20BTK1.42313522
21FGFR31.41968650
22TXK1.37337255
23SGK31.36897130
24ACVR1B1.36866331
25BLK1.24822810
26IKBKE1.16178736
27TEC1.15941660
28MAP4K11.08850934
29JAK11.08448468
30SGK4941.08332759
31SGK2231.08332759
32BMPR1B1.03512388
33MAP2K31.01303332
34WEE11.01262090
35MARK20.94849461
36MARK30.94383771
37MAPK70.88704119
38GRK60.87177508
39WNK10.87072192
40MKNK10.85715128
41RIPK40.83033350
42MAP3K70.77960358
43NEK90.77822217
44TRPM70.77544616
45TYK20.77085883
46CCNB10.73240112
47SYK0.73201580
48CHUK0.72913184
49ZAP700.71875438
50PRKCH0.71140198
51MAP2K40.69862666
52RET0.68888039
53PIM10.68587143
54CDK60.67170862
55STK110.67168049
56SGK10.66687156
57CAMKK20.66314001
58MAP3K20.66216035
59CDK30.65165954
60TNK20.64841780
61PIK3CA0.64486344
62IRAK10.63891776
63HCK0.62429546
64MAP3K40.61780364
65RPS6KB20.61259970
66LATS10.60016383
67FLT30.57250164
68BRSK10.57118294
69PLK40.56898727
70PIK3CG0.56534148
71ATR0.56330642
72MAP3K50.55037049
73CHEK10.54386550
74ITK0.53907404
75MTOR0.53906220
76ATM0.53085735
77IRAK40.52784147
78NEK60.52660560
79LCK0.52050028
80MAPK110.51787693
81CAMK40.51302898
82OBSCN0.50870965
83FER0.47798919
84STK40.47076727
85NUAK10.45800847
86DYRK1A0.44894478
87PDGFRB0.44463041
88JAK30.44355186
89MAP3K140.44345438
90YES10.43750928
91TGFBR10.42762967
92CDC70.42290946
93RPS6KB10.42100512
94CDK40.41153757
95FES0.41129445
96CSK0.40507578
97PRKD20.40255084
98PRKD30.39589243
99LYN0.39027710
100DYRK30.38893776

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.10675973
2B cell receptor signaling pathway_Homo sapiens_hsa046621.97885741
3Lysine degradation_Homo sapiens_hsa003101.96505070
4Non-small cell lung cancer_Homo sapiens_hsa052231.76796744
5Dorso-ventral axis formation_Homo sapiens_hsa043201.73414878
6Prostate cancer_Homo sapiens_hsa052151.66997519
7Phosphatidylinositol signaling system_Homo sapiens_hsa040701.64541182
8Non-homologous end-joining_Homo sapiens_hsa034501.64490252
9FoxO signaling pathway_Homo sapiens_hsa040681.60155751
10T cell receptor signaling pathway_Homo sapiens_hsa046601.56388063
11MicroRNAs in cancer_Homo sapiens_hsa052061.55800259
12Renal cell carcinoma_Homo sapiens_hsa052111.49479048
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48702308
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.48351683
15Inositol phosphate metabolism_Homo sapiens_hsa005621.45424344
16Choline metabolism in cancer_Homo sapiens_hsa052311.45311244
17Chronic myeloid leukemia_Homo sapiens_hsa052201.44237667
18Systemic lupus erythematosus_Homo sapiens_hsa053221.43446293
19Endometrial cancer_Homo sapiens_hsa052131.42073076
20Pancreatic cancer_Homo sapiens_hsa052121.41319356
21Acute myeloid leukemia_Homo sapiens_hsa052211.40513051
22Primary immunodeficiency_Homo sapiens_hsa053401.37482397
23Colorectal cancer_Homo sapiens_hsa052101.36357143
24Measles_Homo sapiens_hsa051621.34917866
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.34307267
26Hepatitis B_Homo sapiens_hsa051611.32116432
27Thyroid hormone signaling pathway_Homo sapiens_hsa049191.31845736
28Prolactin signaling pathway_Homo sapiens_hsa049171.27398064
29Longevity regulating pathway - mammal_Homo sapiens_hsa042111.25008177
30Osteoclast differentiation_Homo sapiens_hsa043801.22230463
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21877201
32mTOR signaling pathway_Homo sapiens_hsa041501.20234292
33Glioma_Homo sapiens_hsa052141.20165330
34p53 signaling pathway_Homo sapiens_hsa041151.18378221
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18321826
36Viral carcinogenesis_Homo sapiens_hsa052031.17947781
37TNF signaling pathway_Homo sapiens_hsa046681.17490195
38RNA degradation_Homo sapiens_hsa030181.15999869
39Leishmaniasis_Homo sapiens_hsa051401.14817319
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14479571
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.12479778
42Homologous recombination_Homo sapiens_hsa034401.11938827
43ErbB signaling pathway_Homo sapiens_hsa040121.11320635
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09217862
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.07984556
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07349594
47Cell cycle_Homo sapiens_hsa041101.05944982
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99186849
49Influenza A_Homo sapiens_hsa051640.98830461
50Toxoplasmosis_Homo sapiens_hsa051450.98603178
51Platelet activation_Homo sapiens_hsa046110.98250880
52Alcoholism_Homo sapiens_hsa050340.97201421
53Adherens junction_Homo sapiens_hsa045200.96400782
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96215365
55Insulin resistance_Homo sapiens_hsa049310.95449300
56Type II diabetes mellitus_Homo sapiens_hsa049300.94313268
57mRNA surveillance pathway_Homo sapiens_hsa030150.94089595
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.87847112
59Herpes simplex infection_Homo sapiens_hsa051680.85021682
60HTLV-I infection_Homo sapiens_hsa051660.84773197
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83355065
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83237266
63Small cell lung cancer_Homo sapiens_hsa052220.82043105
64Hepatitis C_Homo sapiens_hsa051600.81314311
65TGF-beta signaling pathway_Homo sapiens_hsa043500.80664080
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.78957145
67Tuberculosis_Homo sapiens_hsa051520.77781472
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77241774
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76841369
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76689142
71Circadian rhythm_Homo sapiens_hsa047100.75188676
72MAPK signaling pathway_Homo sapiens_hsa040100.73639225
73HIF-1 signaling pathway_Homo sapiens_hsa040660.73619817
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73253342
75Graft-versus-host disease_Homo sapiens_hsa053320.68218750
76GnRH signaling pathway_Homo sapiens_hsa049120.68060892
77Thyroid cancer_Homo sapiens_hsa052160.67912255
78DNA replication_Homo sapiens_hsa030300.67525151
79Estrogen signaling pathway_Homo sapiens_hsa049150.66795247
80Long-term depression_Homo sapiens_hsa047300.65547139
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64820029
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.63851690
83Hematopoietic cell lineage_Homo sapiens_hsa046400.62754934
84Epstein-Barr virus infection_Homo sapiens_hsa051690.61815819
85Notch signaling pathway_Homo sapiens_hsa043300.59254742
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58335187
87Apoptosis_Homo sapiens_hsa042100.57725540
88Taste transduction_Homo sapiens_hsa047420.57698006
89Wnt signaling pathway_Homo sapiens_hsa043100.57087190
90Long-term potentiation_Homo sapiens_hsa047200.55748121
91Proteoglycans in cancer_Homo sapiens_hsa052050.55405816
92Pathways in cancer_Homo sapiens_hsa052000.55014099
93Chemokine signaling pathway_Homo sapiens_hsa040620.53931333
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53900497
95Autoimmune thyroid disease_Homo sapiens_hsa053200.53735573
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.52249330
97VEGF signaling pathway_Homo sapiens_hsa043700.50984892
98ABC transporters_Homo sapiens_hsa020100.50571826
99Melanoma_Homo sapiens_hsa052180.48255450
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45978179

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