ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.62770186
2	DNA deamination (GO:0045006)	4.39504175
3	L-fucose catabolic process (GO:0042355)	4.34969367
4	fucose catabolic process (GO:0019317)	4.34969367
5	L-fucose metabolic process (GO:0042354)	4.34969367
6	response to pheromone (GO:0019236)	4.29074841
7	tryptophan catabolic process (GO:0006569)	3.83059691
8	indole-containing compound catabolic process (GO:0042436)	3.83059691
9	indolalkylamine catabolic process (GO:0046218)	3.83059691
10	negative regulation of telomere maintenance (GO:0032205)	3.74010064
11	cellular ketone body metabolic process (GO:0046950)	3.52427799
12	kynurenine metabolic process (GO:0070189)	3.49667550
13	indolalkylamine metabolic process (GO:0006586)	3.49506813
14	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.48278103
15	somite development (GO:0061053)	3.43319964
16	platelet dense granule organization (GO:0060155)	3.35929404
17	cornea development in camera-type eye (GO:0061303)	3.23589769
18	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.21520211
19	tryptophan metabolic process (GO:0006568)	3.21012992
20	gamma-aminobutyric acid transport (GO:0015812)	3.19924300
21	water-soluble vitamin biosynthetic process (GO:0042364)	3.18196599
22	ketone body metabolic process (GO:1902224)	3.14845822
23	behavioral response to ethanol (GO:0048149)	3.13720574
24	negative regulation of mast cell activation (GO:0033004)	3.13704425
25	neural tube formation (GO:0001841)	3.13239676
26	piRNA metabolic process (GO:0034587)	3.11502108
27	regulation of neurotransmitter uptake (GO:0051580)	3.11474359
28	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.08979773
29	sulfation (GO:0051923)	3.08195354
30	detection of light stimulus involved in sensory perception (GO:0050962)	3.06428101
31	detection of light stimulus involved in visual perception (GO:0050908)	3.06428101
32	neuronal action potential (GO:0019228)	3.05544203
33	protein-cofactor linkage (GO:0018065)	2.99863655
34	cytidine metabolic process (GO:0046087)	2.96101638
35	cytidine catabolic process (GO:0006216)	2.96101638
36	cytidine deamination (GO:0009972)	2.96101638
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.87444165
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.87444165
39	NADH dehydrogenase complex assembly (GO:0010257)	2.87444165
40	protein complex biogenesis (GO:0070271)	2.87350097
41	cellular biogenic amine catabolic process (GO:0042402)	2.86338604
42	amine catabolic process (GO:0009310)	2.86338604
43	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.84519145
44	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.84519145
45	regulation of hexokinase activity (GO:1903299)	2.81691086
46	regulation of glucokinase activity (GO:0033131)	2.81691086
47	ubiquinone biosynthetic process (GO:0006744)	2.79529219
48	respiratory chain complex IV assembly (GO:0008535)	2.78428210
49	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.77294705
50	regulation of cilium movement (GO:0003352)	2.77052639
51	epithelial cilium movement (GO:0003351)	2.75479225
52	reciprocal meiotic recombination (GO:0007131)	2.75405613
53	reciprocal DNA recombination (GO:0035825)	2.75405613
54	nephron epithelium morphogenesis (GO:0072088)	2.75184150
55	nephron tubule morphogenesis (GO:0072078)	2.75184150
56	indole-containing compound metabolic process (GO:0042430)	2.75043282
57	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.71610035
58	somite rostral/caudal axis specification (GO:0032525)	2.70610783
59	primary amino compound metabolic process (GO:1901160)	2.70345489
60	nonmotile primary cilium assembly (GO:0035058)	2.70090773
61	serotonin receptor signaling pathway (GO:0007210)	2.69817652
62	proline transport (GO:0015824)	2.69810785
63	regulation of action potential (GO:0098900)	2.69574627
64	mitochondrial respiratory chain complex assembly (GO:0033108)	2.69423686
65	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.69387764
66	preassembly of GPI anchor in ER membrane (GO:0016254)	2.69211003
67	DNA methylation involved in gamete generation (GO:0043046)	2.68510495
68	reflex (GO:0060004)	2.66666222
69	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.65998759
70	postsynaptic membrane organization (GO:0001941)	2.64907401
71	adaptation of signaling pathway (GO:0023058)	2.64269448
72	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.63129210
73	axoneme assembly (GO:0035082)	2.62455884
74	photoreceptor cell development (GO:0042461)	2.61730606
75	rRNA catabolic process (GO:0016075)	2.61400717
76	ubiquinone metabolic process (GO:0006743)	2.59762885
77	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.59133800
78	positive regulation of prostaglandin secretion (GO:0032308)	2.59097474
79	multicellular organism reproduction (GO:0032504)	2.56532470
80	aromatic amino acid family catabolic process (GO:0009074)	2.56362153
81	positive regulation of fatty acid transport (GO:2000193)	2.56235634
82	kidney morphogenesis (GO:0060993)	2.55025143
83	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.54474863
84	pyrimidine nucleobase catabolic process (GO:0006208)	2.54254271
85	sulfate transmembrane transport (GO:1902358)	2.53009725
86	startle response (GO:0001964)	2.52541674
87	rhodopsin mediated signaling pathway (GO:0016056)	2.52404422
88	protein polyglutamylation (GO:0018095)	2.52255646
89	cilium morphogenesis (GO:0060271)	2.51811493
90	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.48341476
91	synaptic transmission, cholinergic (GO:0007271)	2.46834212
92	cytochrome complex assembly (GO:0017004)	2.46726293
93	cAMP catabolic process (GO:0006198)	2.46668043
94	protein K6-linked ubiquitination (GO:0085020)	2.46549635
95	photoreceptor cell maintenance (GO:0045494)	2.46375625
96	fucosylation (GO:0036065)	2.45864155
97	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.44943079
98	regulation of telomere maintenance (GO:0032204)	2.44532217
99	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.43487774
100	dopamine transport (GO:0015872)	2.42258828

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.95462968
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.54035994
3	VDR_22108803_ChIP-Seq_LS180_Human	3.18570108
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.10810149
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.69251950
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.65591234
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.59604621
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.44353639
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.36623426
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.24093508
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.05971629
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.03293506
13	FUS_26573619_Chip-Seq_HEK293_Human	2.01279601
14	P300_19829295_ChIP-Seq_ESCs_Human	1.96127050
15	EWS_26573619_Chip-Seq_HEK293_Human	1.95535784
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.93374188
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.92545921
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.92156816
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.81183548
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.64959322
21	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.63684040
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.63628296
23	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.61207151
24	BCAT_22108803_ChIP-Seq_LS180_Human	1.60660725
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59278367
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.58806364
27	REST_21632747_ChIP-Seq_MESCs_Mouse	1.56785596
28	AR_25329375_ChIP-Seq_VCAP_Human	1.51570493
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.51115488
30	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.50042846
31	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.47977948
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47839846
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.47623452
34	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.46659275
35	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.46590067
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.45806176
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.45124452
38	STAT3_23295773_ChIP-Seq_U87_Human	1.45041602
39	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.44174246
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.42820272
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.42820272
42	IRF1_19129219_ChIP-ChIP_H3396_Human	1.42532524
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42352858
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.42352858
45	AR_21572438_ChIP-Seq_LNCaP_Human	1.41309532
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.41101110
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.40589462
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39772005
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.39772005
50	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.39346677
51	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.36253337
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.33794901
53	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.31756044
54	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.31454235
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30999470
56	TCF4_23295773_ChIP-Seq_U87_Human	1.30532525
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29686524
58	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29686524
59	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.27950175
60	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24385630
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.24127597
62	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.24009909
63	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.23839095
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.22884500
65	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21136023
66	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.18504866
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17326171
68	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.17199104
69	HOXB7_26014856_ChIP-Seq_BT474_Human	1.17094350
70	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.16881967
71	NCOR_22424771_ChIP-Seq_293T_Human	1.16595783
72	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16178828
73	AR_20517297_ChIP-Seq_VCAP_Human	1.14121712
74	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13883975
75	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13721356
76	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13163493
77	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.12418127
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12209818
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11756713
80	RNF2_27304074_Chip-Seq_NSC_Mouse	1.11737901
81	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.11604914
82	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10565494
83	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09735932
84	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.09358997
85	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.08912815
86	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06534273
87	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.05663052
88	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05451798
89	MYC_19829295_ChIP-Seq_ESCs_Human	1.03062268
90	ERA_21632823_ChIP-Seq_H3396_Human	1.00364155
91	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00011760
92	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.99141649
93	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.98327902
94	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.98081078
95	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.97019875
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95745466
97	TAF2_19829295_ChIP-Seq_ESCs_Human	0.95186664
98	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.94733948
99	P53_22387025_ChIP-Seq_ESCs_Mouse	0.93971289
100	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.93926282

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.36756236
2	MP0000569_abnormal_digit_pigmentation	3.22061233
3	MP0000372_irregular_coat_pigmentation	2.69615427
4	MP0002837_dystrophic_cardiac_calcinosis	2.68461597
5	MP0001968_abnormal_touch/_nociception	2.48163665
6	MP0003195_calcinosis	2.41192225
7	MP0005551_abnormal_eye_electrophysiolog	2.34096347
8	MP0002653_abnormal_ependyma_morphology	2.30474330
9	MP0008877_abnormal_DNA_methylation	2.30332377
10	MP0003880_abnormal_central_pattern	2.17050102
11	MP0004142_abnormal_muscle_tone	2.17045476
12	MP0008872_abnormal_physiological_respon	2.13118731
13	MP0003646_muscle_fatigue	2.10243331
14	MP0008875_abnormal_xenobiotic_pharmacok	2.08051389
15	MP0009745_abnormal_behavioral_response	2.06928489
16	MP0006292_abnormal_olfactory_placode	2.05066785
17	MP0005174_abnormal_tail_pigmentation	2.03801472
18	MP0002938_white_spotting	2.02127180
19	MP0009046_muscle_twitch	1.95450147
20	MP0003787_abnormal_imprinting	1.94403489
21	MP0004885_abnormal_endolymph	1.87688510
22	MP0004147_increased_porphyrin_level	1.86182360
23	MP0002736_abnormal_nociception_after	1.80537665
24	MP0006072_abnormal_retinal_apoptosis	1.78212255
25	MP0002102_abnormal_ear_morphology	1.77572980
26	MP0002272_abnormal_nervous_system	1.76376025
27	MP0001986_abnormal_taste_sensitivity	1.76342368
28	MP0000427_abnormal_hair_cycle	1.75261975
29	MP0002733_abnormal_thermal_nociception	1.73588115
30	MP0006276_abnormal_autonomic_nervous	1.69890650
31	MP0002735_abnormal_chemical_nociception	1.69734189
32	MP0002876_abnormal_thyroid_physiology	1.57901803
33	MP0001501_abnormal_sleep_pattern	1.56111846
34	MP0004043_abnormal_pH_regulation	1.52432369
35	MP0002064_seizures	1.48115189
36	MP0002095_abnormal_skin_pigmentation	1.46969992
37	MP0001970_abnormal_pain_threshold	1.46455949
38	MP0005645_abnormal_hypothalamus_physiol	1.43178890
39	MP0004133_heterotaxia	1.42219804
40	MP0005253_abnormal_eye_physiology	1.38703080
41	MP0002572_abnormal_emotion/affect_behav	1.37776366
42	MP0001485_abnormal_pinna_reflex	1.35983147
43	MP0002277_abnormal_respiratory_mucosa	1.35774057
44	MP0001486_abnormal_startle_reflex	1.35009034
45	MP0005646_abnormal_pituitary_gland	1.34317828
46	MP0004742_abnormal_vestibular_system	1.32402626
47	MP0003011_delayed_dark_adaptation	1.27924198
48	MP0000015_abnormal_ear_pigmentation	1.27766931
49	MP0000631_abnormal_neuroendocrine_gland	1.27388754
50	MP0005084_abnormal_gallbladder_morpholo	1.26761248
51	MP0002163_abnormal_gland_morphology	1.26423230
52	MP0001984_abnormal_olfaction	1.22372389
53	MP0004145_abnormal_muscle_electrophysio	1.21735110
54	MP0001440_abnormal_grooming_behavior	1.20123913
55	MP0001905_abnormal_dopamine_level	1.16509074
56	MP0005410_abnormal_fertilization	1.15781317
57	MP0005171_absent_coat_pigmentation	1.13851499
58	MP0005423_abnormal_somatic_nervous	1.11916306
59	MP0003635_abnormal_synaptic_transmissio	1.09725862
60	MP0002557_abnormal_social/conspecific_i	1.09071961
61	MP0002063_abnormal_learning/memory/cond	1.08916080
62	MP0002067_abnormal_sensory_capabilities	1.08450523
63	MP0003890_abnormal_embryonic-extraembry	1.04591399
64	MP0000778_abnormal_nervous_system	1.04207295
65	MP0005389_reproductive_system_phenotype	1.03900782
66	MP0005195_abnormal_posterior_eye	1.02704842
67	MP0001919_abnormal_reproductive_system	1.02315384
68	MP0003121_genomic_imprinting	1.00437946
69	MP0002638_abnormal_pupillary_reflex	0.99669445
70	MP0003122_maternal_imprinting	0.99510795
71	MP0002234_abnormal_pharynx_morphology	0.95749418
72	MP0001324_abnormal_eye_pigmentation	0.95521728
73	MP0002734_abnormal_mechanical_nocicepti	0.94880170
74	MP0005085_abnormal_gallbladder_physiolo	0.92374027
75	MP0003718_maternal_effect	0.90828562
76	MP0002928_abnormal_bile_duct	0.87850159
77	MP0003137_abnormal_impulse_conducting	0.87749439
78	MP0000647_abnormal_sebaceous_gland	0.87251962
79	MP0000026_abnormal_inner_ear	0.86802872
80	MP0004215_abnormal_myocardial_fiber	0.86439315
81	MP0002160_abnormal_reproductive_system	0.86419096
82	MP0002752_abnormal_somatic_nervous	0.86236035
83	MP0005379_endocrine/exocrine_gland_phen	0.86002450
84	MP0005167_abnormal_blood-brain_barrier	0.85458487
85	MP0000230_abnormal_systemic_arterial	0.84421915
86	MP0005365_abnormal_bile_salt	0.83274543
87	MP0001502_abnormal_circadian_rhythm	0.83159609
88	MP0005448_abnormal_energy_balance	0.81406989
89	MP0002751_abnormal_autonomic_nervous	0.80063418
90	MP0002822_catalepsy	0.79786901
91	MP0010386_abnormal_urinary_bladder	0.78592206
92	MP0002184_abnormal_innervation	0.77847164
93	MP0005075_abnormal_melanosome_morpholog	0.77040164
94	MP0000566_synostosis	0.76100746
95	MP0002254_reproductive_system_inflammat	0.76065323
96	MP0005386_behavior/neurological_phenoty	0.75576392
97	MP0004924_abnormal_behavior	0.75576392
98	MP0003698_abnormal_male_reproductive	0.74271810
99	MP0001963_abnormal_hearing_physiology	0.73101213
100	MP0005332_abnormal_amino_acid	0.71845189

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.67303478
2	Abnormality of midbrain morphology (HP:0002418)	4.57878277
3	Molar tooth sign on MRI (HP:0002419)	4.57878277
4	Pancreatic fibrosis (HP:0100732)	4.33677172
5	True hermaphroditism (HP:0010459)	4.10755962
6	Nephronophthisis (HP:0000090)	3.74562788
7	Congenital stationary night blindness (HP:0007642)	3.51996584
8	Abnormality of the renal medulla (HP:0100957)	3.24459510
9	Abnormality of the renal cortex (HP:0011035)	3.13505419
10	Hyperventilation (HP:0002883)	3.10709677
11	Cystic liver disease (HP:0006706)	3.04203639
12	Type II lissencephaly (HP:0007260)	2.95517819
13	Tubular atrophy (HP:0000092)	2.76441316
14	Medial flaring of the eyebrow (HP:0010747)	2.76158735
15	Large for gestational age (HP:0001520)	2.73834005
16	Chronic hepatic failure (HP:0100626)	2.71850090
17	Sclerocornea (HP:0000647)	2.60361692
18	Polydipsia (HP:0001959)	2.55270356
19	Abnormal drinking behavior (HP:0030082)	2.55270356
20	Attenuation of retinal blood vessels (HP:0007843)	2.50051402
21	Furrowed tongue (HP:0000221)	2.49491795
22	Congenital, generalized hypertrichosis (HP:0004540)	2.48300732
23	Focal motor seizures (HP:0011153)	2.46328684
24	Pendular nystagmus (HP:0012043)	2.45679552
25	Inability to walk (HP:0002540)	2.45373394
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.44644996
27	Abnormality of the labia minora (HP:0012880)	2.43386906
28	Abolished electroretinogram (ERG) (HP:0000550)	2.41724433
29	Acute necrotizing encephalopathy (HP:0006965)	2.38204321
30	Abnormality of alanine metabolism (HP:0010916)	2.37360148
31	Hyperalaninemia (HP:0003348)	2.37360148
32	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.37360148
33	Polyuria (HP:0000103)	2.36413220
34	Anencephaly (HP:0002323)	2.35673000
35	Hyperglycinuria (HP:0003108)	2.34214798
36	Progressive cerebellar ataxia (HP:0002073)	2.34144198
37	Mitochondrial inheritance (HP:0001427)	2.31258314
38	Progressive inability to walk (HP:0002505)	2.28901859
39	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.27100728
40	Absent/shortened dynein arms (HP:0200106)	2.27100728
41	Acute encephalopathy (HP:0006846)	2.26605199
42	Lissencephaly (HP:0001339)	2.25757737
43	3-Methylglutaconic aciduria (HP:0003535)	2.25153648
44	Concave nail (HP:0001598)	2.23581360
45	Congenital hepatic fibrosis (HP:0002612)	2.23124840
46	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.22888303
47	Decreased central vision (HP:0007663)	2.19905706
48	Keratoconus (HP:0000563)	2.18816124
49	Increased corneal curvature (HP:0100692)	2.18816124
50	Gait imbalance (HP:0002141)	2.17908744
51	Patellar aplasia (HP:0006443)	2.17495359
52	Renal cortical cysts (HP:0000803)	2.17433048
53	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.17135707
54	Optic disc pallor (HP:0000543)	2.16405931
55	Male pseudohermaphroditism (HP:0000037)	2.13478055
56	Progressive macrocephaly (HP:0004481)	2.08412784
57	Aplasia/Hypoplasia of the patella (HP:0006498)	2.05665134
58	Febrile seizures (HP:0002373)	2.05451955
59	Cerebellar dysplasia (HP:0007033)	2.02877595
60	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.02618114
61	Abnormality of the pons (HP:0007361)	2.00782678
62	Increased CSF lactate (HP:0002490)	1.99510243
63	Congenital primary aphakia (HP:0007707)	1.98325913
64	Nephrogenic diabetes insipidus (HP:0009806)	1.98320522
65	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.97648916
66	Broad-based gait (HP:0002136)	1.96908185
67	Severe muscular hypotonia (HP:0006829)	1.95345971
68	Gaze-evoked nystagmus (HP:0000640)	1.94484891
69	Focal seizures (HP:0007359)	1.91105890
70	Occipital encephalocele (HP:0002085)	1.90518072
71	Hypomagnesemia (HP:0002917)	1.90331119
72	Abnormal mitochondria in muscle tissue (HP:0008316)	1.88920529
73	Hemiparesis (HP:0001269)	1.88822085
74	Optic nerve hypoplasia (HP:0000609)	1.88765771
75	Amelogenesis imperfecta (HP:0000705)	1.88407540
76	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.87613830
77	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.87065931
78	Hypoplasia of the fovea (HP:0007750)	1.87065931
79	Abnormal urine output (HP:0012590)	1.86485784
80	Postaxial foot polydactyly (HP:0001830)	1.85302946
81	Abnormality of glycine metabolism (HP:0010895)	1.84701596
82	Abnormality of serine family amino acid metabolism (HP:0010894)	1.84701596
83	Polyphagia (HP:0002591)	1.83325059
84	Aplasia/hypoplasia of the uterus (HP:0008684)	1.79986262
85	Bile duct proliferation (HP:0001408)	1.79783316
86	Abnormal biliary tract physiology (HP:0012439)	1.79783316
87	Hypoplasia of the pons (HP:0012110)	1.79433661
88	Hypothermia (HP:0002045)	1.79400563
89	Methylmalonic acidemia (HP:0002912)	1.79237440
90	Protruding tongue (HP:0010808)	1.79038153
91	Retinal dysplasia (HP:0007973)	1.78923201
92	Bilateral microphthalmos (HP:0007633)	1.76508628
93	Genital tract atresia (HP:0001827)	1.76130886
94	Hepatocellular necrosis (HP:0001404)	1.75759900
95	Congenital sensorineural hearing impairment (HP:0008527)	1.74788942
96	Dialeptic seizures (HP:0011146)	1.74429674
97	Increased hepatocellular lipid droplets (HP:0006565)	1.73737512
98	Pachygyria (HP:0001302)	1.73213666
99	Abnormal respiratory motile cilium morphology (HP:0005938)	1.72720362
100	Abnormal respiratory epithelium morphology (HP:0012253)	1.72720362

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.49469625
2	INSRR	3.34321592
3	ADRBK2	3.18005477
4	BMPR1B	3.01401806
5	TLK1	3.00618087
6	WNK4	2.76604373
7	ZAK	2.74133961
8	PINK1	2.62024227
9	WNK3	2.51131558
10	MAP4K2	2.41559199
11	CASK	2.40849884
12	GRK1	2.17692377
13	MAPK13	2.08864165
14	ACVR1B	2.01000332
15	NUAK1	1.98704801
16	MARK1	1.82520872
17	STK39	1.80039376
18	TNIK	1.75842241
19	TXK	1.75409140
20	PNCK	1.74855752
21	OXSR1	1.73075240
22	STK38L	1.46576960
23	TAOK3	1.46006902
24	MAP3K4	1.43462465
25	DYRK2	1.42225923
26	MAPK15	1.28138504
27	DAPK2	1.22954199
28	VRK1	1.22199346
29	CAMKK2	1.21169720
30	ADRBK1	1.14889663
31	NTRK2	1.13549522
32	EPHA4	1.10527808
33	PHKG2	1.09295941
34	PHKG1	1.09295941
35	PAK3	1.08180083
36	PRKCG	1.05373691
37	BCKDK	1.03033329
38	MAPKAPK3	1.01920472
39	SIK2	0.99671195
40	STK3	0.97496615
41	NTRK3	0.97438739
42	TRIM28	0.97060357
43	PRKCE	0.92324914
44	MAP2K6	0.91266223
45	MAP2K7	0.90182257
46	MST4	0.90069666
47	PTK2B	0.88158388
48	TGFBR1	0.85921936
49	NEK2	0.85774268
50	WEE1	0.83634090
51	MKNK2	0.83176272
52	PIK3CA	0.80376000
53	CSNK1G2	0.79582570
54	BRSK2	0.79439066
55	LATS1	0.79037684
56	CSNK1G1	0.74457179
57	PRKCQ	0.72368537
58	CSNK1G3	0.65099768
59	TAF1	0.64975950
60	VRK2	0.64602002
61	NLK	0.64381495
62	CAMK2A	0.61519029
63	CSNK1A1L	0.61333966
64	TIE1	0.58324327
65	GRK7	0.56972073
66	PLK3	0.56131690
67	RPS6KA5	0.55816668
68	STK11	0.52929502
69	IKBKB	0.52055263
70	MAP3K12	0.51962158
71	TEC	0.47434956
72	PRKACA	0.47382861
73	PLK2	0.46321388
74	PRKCI	0.46225191
75	MAPKAPK5	0.45592521
76	PKN1	0.45526827
77	MUSK	0.44328470
78	PRKCZ	0.43621784
79	MAP3K11	0.43518786
80	CDK3	0.42988065
81	IRAK1	0.42766654
82	TYRO3	0.42761439
83	CAMK1	0.42490318
84	CHEK2	0.41532774
85	NME1	0.41305714
86	CSNK1A1	0.41121802
87	FGFR2	0.40133099
88	TSSK6	0.39800642
89	ITK	0.37747592
90	PRKCA	0.34972364
91	WNK1	0.33776516
92	TNK2	0.31792531
93	KIT	0.31419423
94	CSNK1D	0.31044751
95	MKNK1	0.30713097
96	DYRK1A	0.29512167
97	PRKG1	0.28596950
98	CHUK	0.28419412
99	PLK1	0.27269752
100	BCR	0.25322829

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.70513456
2	Phototransduction_Homo sapiens_hsa04744	2.69879047
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.65112571
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.57615523
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.42815515
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.36470251
7	Butanoate metabolism_Homo sapiens_hsa00650	2.29446664
8	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.15321786
9	Nicotine addiction_Homo sapiens_hsa05033	2.14413943
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.14260792
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.11641603
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10400574
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.99800790
14	Parkinsons disease_Homo sapiens_hsa05012	1.98326593
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.91887417
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.90832200
17	Protein export_Homo sapiens_hsa03060	1.89568012
18	Homologous recombination_Homo sapiens_hsa03440	1.80065929
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.74253063
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.69283848
21	RNA polymerase_Homo sapiens_hsa03020	1.63194188
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.60049572
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.56453084
24	Taste transduction_Homo sapiens_hsa04742	1.48830295
25	Basal transcription factors_Homo sapiens_hsa03022	1.48000136
26	Caffeine metabolism_Homo sapiens_hsa00232	1.47273116
27	Olfactory transduction_Homo sapiens_hsa04740	1.40119819
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.38872824
29	Propanoate metabolism_Homo sapiens_hsa00640	1.37971003
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.37006857
31	One carbon pool by folate_Homo sapiens_hsa00670	1.33056555
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.31159627
33	Morphine addiction_Homo sapiens_hsa05032	1.29272907
34	Alzheimers disease_Homo sapiens_hsa05010	1.26539140
35	Huntingtons disease_Homo sapiens_hsa05016	1.23848652
36	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.19446053
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.18892570
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.16740535
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.15967426
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.15445472
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.13379138
42	ABC transporters_Homo sapiens_hsa02010	1.12228877
43	Peroxisome_Homo sapiens_hsa04146	1.10734984
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.10108373
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.08756886
46	Sulfur metabolism_Homo sapiens_hsa00920	1.06936111
47	Collecting duct acid secretion_Homo sapiens_hsa04966	1.06829348
48	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.05842151
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.04826886
50	RNA degradation_Homo sapiens_hsa03018	1.01214712
51	Proteasome_Homo sapiens_hsa03050	1.00682560
52	Insulin secretion_Homo sapiens_hsa04911	0.99340426
53	Regulation of autophagy_Homo sapiens_hsa04140	0.95479407
54	GABAergic synapse_Homo sapiens_hsa04727	0.93328211
55	Serotonergic synapse_Homo sapiens_hsa04726	0.92709531
56	Primary immunodeficiency_Homo sapiens_hsa05340	0.87137361
57	Glutamatergic synapse_Homo sapiens_hsa04724	0.86536093
58	Retinol metabolism_Homo sapiens_hsa00830	0.86047690
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.84717791
60	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.81118186
61	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.81072135
62	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.77640762
63	Asthma_Homo sapiens_hsa05310	0.74726115
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.74370396
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.73782106
66	Circadian entrainment_Homo sapiens_hsa04713	0.73771926
67	Graft-versus-host disease_Homo sapiens_hsa05332	0.73263775
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.69364198
69	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.68244682
70	Type I diabetes mellitus_Homo sapiens_hsa04940	0.66834936
71	Purine metabolism_Homo sapiens_hsa00230	0.63603725
72	Metabolic pathways_Homo sapiens_hsa01100	0.63189628
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62929731
74	Calcium signaling pathway_Homo sapiens_hsa04020	0.61116343
75	Steroid biosynthesis_Homo sapiens_hsa00100	0.58107424
76	Histidine metabolism_Homo sapiens_hsa00340	0.56934941
77	Circadian rhythm_Homo sapiens_hsa04710	0.56735487
78	Mineral absorption_Homo sapiens_hsa04978	0.55588063
79	Nucleotide excision repair_Homo sapiens_hsa03420	0.54336963
80	Sulfur relay system_Homo sapiens_hsa04122	0.53766609
81	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53184328
82	Allograft rejection_Homo sapiens_hsa05330	0.52169602
83	Salivary secretion_Homo sapiens_hsa04970	0.51245675
84	Rheumatoid arthritis_Homo sapiens_hsa05323	0.51059996
85	Ribosome_Homo sapiens_hsa03010	0.50812742
86	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.50640891
87	Cocaine addiction_Homo sapiens_hsa05030	0.50495257
88	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.49809270
89	Dopaminergic synapse_Homo sapiens_hsa04728	0.44637216
90	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.44502187
91	Pyrimidine metabolism_Homo sapiens_hsa00240	0.41096434
92	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.40238552
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38825733
94	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.38428567
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37858635
96	Fatty acid elongation_Homo sapiens_hsa00062	0.37392995
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36492552
98	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.35136961
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.32258969
100	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.31853301

PSMD10P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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