PSMD12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.02490342
2purine nucleobase biosynthetic process (GO:0009113)4.93971479
3nucleobase biosynthetic process (GO:0046112)4.86298824
4protein K11-linked deubiquitination (GO:0035871)4.80373663
5formation of translation preinitiation complex (GO:0001731)4.75623224
6ribosome assembly (GO:0042255)4.68578994
7DNA double-strand break processing (GO:0000729)4.68409161
8mitotic metaphase plate congression (GO:0007080)4.37869563
9cullin deneddylation (GO:0010388)4.34394213
10* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.31610212
11ribosome biogenesis (GO:0042254)4.28159291
12maturation of SSU-rRNA (GO:0030490)4.26284331
13* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.21496916
14* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.16863167
15DNA replication checkpoint (GO:0000076)4.16394000
16* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.15477761
17protein deneddylation (GO:0000338)4.08607700
18DNA strand elongation involved in DNA replication (GO:0006271)4.07932691
19DNA replication initiation (GO:0006270)3.94323852
20* negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.89474169
21* negative regulation of ligase activity (GO:0051352)3.89474169
22DNA strand elongation (GO:0022616)3.85541687
23ribosomal large subunit biogenesis (GO:0042273)3.83332489
24ribonucleoprotein complex biogenesis (GO:0022613)3.82615169
25* regulation of cellular amino acid metabolic process (GO:0006521)3.81445913
26* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.77561210
27telomere maintenance via semi-conservative replication (GO:0032201)3.73326368
28spliceosomal snRNP assembly (GO:0000387)3.69172399
29protein K6-linked ubiquitination (GO:0085020)3.68597231
30regulation of centriole replication (GO:0046599)3.68090323
31metaphase plate congression (GO:0051310)3.64611698
32replication fork processing (GO:0031297)3.64426012
33rRNA modification (GO:0000154)3.64119799
34double-strand break repair via nonhomologous end joining (GO:0006303)3.64020109
35non-recombinational repair (GO:0000726)3.64020109
36* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.63847719
37CENP-A containing nucleosome assembly (GO:0034080)3.62650860
38chromatin remodeling at centromere (GO:0031055)3.60476187
39maturation of 5.8S rRNA (GO:0000460)3.60383003
40IMP biosynthetic process (GO:0006188)3.58836002
41* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.58304249
42* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.58304249
43DNA deamination (GO:0045006)3.57814205
44* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.57752448
45* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.57752448
46* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.57752448
47* positive regulation of ligase activity (GO:0051351)3.56359046
48folic acid metabolic process (GO:0046655)3.56168236
49* signal transduction involved in DNA damage checkpoint (GO:0072422)3.56023460
50* signal transduction involved in DNA integrity checkpoint (GO:0072401)3.56023460
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.54547710
52mitotic nuclear envelope disassembly (GO:0007077)3.54256136
53DNA replication-dependent nucleosome assembly (GO:0006335)3.53721915
54DNA replication-dependent nucleosome organization (GO:0034723)3.53721915
55rRNA processing (GO:0006364)3.53539574
56* signal transduction involved in cell cycle checkpoint (GO:0072395)3.51080393
57folic acid-containing compound biosynthetic process (GO:0009396)3.50939468
58DNA catabolic process, exonucleolytic (GO:0000738)3.50067969
59establishment of protein localization to mitochondrial membrane (GO:0090151)3.49633828
60negative regulation of DNA-dependent DNA replication (GO:2000104)3.48130986
61regulation of DNA endoreduplication (GO:0032875)3.45137113
62establishment of integrated proviral latency (GO:0075713)3.42305267
63rRNA metabolic process (GO:0016072)3.40380702
64telomere maintenance via recombination (GO:0000722)3.38721912
657-methylguanosine mRNA capping (GO:0006370)3.38591490
66mitotic sister chromatid segregation (GO:0000070)3.38092542
67* G1/S transition of mitotic cell cycle (GO:0000082)3.36623251
68* cell cycle G1/S phase transition (GO:0044843)3.36623251
69DNA unwinding involved in DNA replication (GO:0006268)3.36343193
70pseudouridine synthesis (GO:0001522)3.35460354
71transcription elongation from RNA polymerase III promoter (GO:0006385)3.33351813
72termination of RNA polymerase III transcription (GO:0006386)3.33351813
73* regulation of ubiquitin-protein transferase activity (GO:0051438)3.32651795
74protein localization to kinetochore (GO:0034501)3.30794759
75synapsis (GO:0007129)3.30317760
767-methylguanosine RNA capping (GO:0009452)3.30267958
77RNA capping (GO:0036260)3.30267958
78nuclear envelope disassembly (GO:0051081)3.28481422
79membrane disassembly (GO:0030397)3.28481422
80regulation of translational termination (GO:0006449)3.28061505
81L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.27623976
82regulation of translation in response to stress (GO:0043555)3.27002497
83mitotic sister chromatid cohesion (GO:0007064)3.25003250
84DNA replication-independent nucleosome organization (GO:0034724)3.24715701
85DNA replication-independent nucleosome assembly (GO:0006336)3.24715701
86mitotic recombination (GO:0006312)3.23160281
87* antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.21713583
88kinetochore organization (GO:0051383)3.21557393
89transcription-coupled nucleotide-excision repair (GO:0006283)3.20196087
90IMP metabolic process (GO:0046040)3.19582579
91nuclear pore complex assembly (GO:0051292)3.19348760
92* regulation of ligase activity (GO:0051340)3.16818980
93sister chromatid segregation (GO:0000819)3.15674077
94regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.15291606
95cellular component biogenesis (GO:0044085)3.15139628
96regulation of mitochondrial translation (GO:0070129)3.15046749
97telomere maintenance via telomere lengthening (GO:0010833)3.14604556
98regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.14301916
99histone exchange (GO:0043486)3.14188762
100nuclear pore organization (GO:0006999)3.13754241
101spliceosomal complex assembly (GO:0000245)3.13577087
102regulation of spindle organization (GO:0090224)3.13201616
103negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12916614
104negative regulation of sister chromatid segregation (GO:0033046)3.12916614
105negative regulation of mitotic sister chromatid separation (GO:2000816)3.12916614
106negative regulation of mitotic sister chromatid segregation (GO:0033048)3.12916614
107establishment of chromosome localization (GO:0051303)3.12501786
108kinetochore assembly (GO:0051382)3.10680163
109negative regulation of chromosome segregation (GO:0051985)3.10346611
110RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.09021086
111termination of RNA polymerase I transcription (GO:0006363)3.08891159
112amino acid salvage (GO:0043102)3.08570081
113L-methionine salvage (GO:0071267)3.08570081
114L-methionine biosynthetic process (GO:0071265)3.08570081
115mitotic spindle checkpoint (GO:0071174)3.08287047
116mitotic spindle assembly checkpoint (GO:0007094)3.07787752
117spindle checkpoint (GO:0031577)3.07531329
118translational initiation (GO:0006413)3.07320663
119attachment of spindle microtubules to kinetochore (GO:0008608)3.07004434
120transcription from RNA polymerase I promoter (GO:0006360)3.06012410
121mitochondrial RNA metabolic process (GO:0000959)3.03233285
122peptidyl-histidine modification (GO:0018202)3.02995269
123protein localization to chromosome, centromeric region (GO:0071459)3.01941638
124maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99761009
125positive regulation of chromosome segregation (GO:0051984)2.97098399
126regulation of cofactor metabolic process (GO:0051193)2.93781917
127regulation of coenzyme metabolic process (GO:0051196)2.93781917
128regulation of acyl-CoA biosynthetic process (GO:0050812)2.92226215
129regulation of centrosome cycle (GO:0046605)2.90872481
130transcription from mitochondrial promoter (GO:0006390)2.90293392
131histone mRNA metabolic process (GO:0008334)2.88859100
132isotype switching (GO:0045190)2.87937716
133somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.87937716
134somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.87937716
135regulation of chromosome segregation (GO:0051983)2.87684399
136nucleotide-excision repair, DNA gap filling (GO:0006297)2.85949905
137regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.81777232
138regulation of mitotic spindle checkpoint (GO:1903504)2.81777232

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.59082628
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.63787378
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.09667913
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83348047
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.66422052
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.63070036
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.53329501
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.42192089
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.35004744
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.19522940
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.18004243
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.11190193
13MYC_19030024_ChIP-ChIP_MESCs_Mouse3.07465294
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.85649347
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.75486753
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.73582459
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.70435904
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.68876841
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63681000
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.59778005
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.49061327
22* VDR_23849224_ChIP-Seq_CD4+_Human2.47256501
23XRN2_22483619_ChIP-Seq_HELA_Human2.44838629
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.36557614
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28370942
26* DCP1A_22483619_ChIP-Seq_HELA_Human2.25750218
27AR_21909140_ChIP-Seq_LNCAP_Human2.20635456
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.15781316
29* GABP_19822575_ChIP-Seq_HepG2_Human2.11006858
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08435583
31FOXP3_21729870_ChIP-Seq_TREG_Human2.08124673
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.02051319
33MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00968866
34ELK1_19687146_ChIP-ChIP_HELA_Human1.90809752
35TTF2_22483619_ChIP-Seq_HELA_Human1.90322364
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.88452706
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84877230
38* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81541495
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81239171
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.79800999
41* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78351871
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.78201153
43EWS_26573619_Chip-Seq_HEK293_Human1.71970423
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71927821
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70473121
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68964407
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.68954353
48* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68919491
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.65623310
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52521021
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50737263
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46993220
53KDM5A_27292631_Chip-Seq_BREAST_Human1.45764332
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44918828
55FUS_26573619_Chip-Seq_HEK293_Human1.44364424
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42626700
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42324042
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.41562145
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39182976
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37962796
61* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36815494
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36021792
63ZNF274_21170338_ChIP-Seq_K562_Hela1.34785768
64VDR_22108803_ChIP-Seq_LS180_Human1.34610954
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33057509
66TAF15_26573619_Chip-Seq_HEK293_Human1.31938986
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31551827
68* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27068841
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.25060268
70CIITA_25753668_ChIP-Seq_RAJI_Human1.23365387
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20393039
72* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20292581
73IGF1R_20145208_ChIP-Seq_DFB_Human1.19084412
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17251552
75SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14969870
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14906000
77TFEB_21752829_ChIP-Seq_HELA_Human1.12609954
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11286850
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09678525
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07674435
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04802097
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04738529
83* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04623308
84EGR1_19374776_ChIP-ChIP_THP-1_Human1.03361439
85MYC_18940864_ChIP-ChIP_HL60_Human1.02933243
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02736835
87GBX2_23144817_ChIP-Seq_PC3_Human1.02532406
88* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00905882
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00581724
90NANOG_16153702_ChIP-ChIP_HESCs_Human0.99194551
91* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99068211
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95692785
93* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95612420
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95421628
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94816418
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94190718
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93305253
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92777945
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92229017
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91924056
101TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91462864
102NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.90511662
103SALL1_21062744_ChIP-ChIP_HESCs_Human0.90161140
104OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90004297
105SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89716628
106ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89383687
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.89288396
108EZH2_27294783_Chip-Seq_NPCs_Mouse0.88943213
109NOTCH1_21737748_ChIP-Seq_TLL_Human0.88651033
110ER_23166858_ChIP-Seq_MCF-7_Human0.88634805
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88139153
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87955426
113NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86368966
114P300_19829295_ChIP-Seq_ESCs_Human0.86318365
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85612537
116POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84986098
117ELF5_23300383_ChIP-Seq_T47D_Human0.83360638
118TP53_22573176_ChIP-Seq_HFKS_Human0.83244212
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83240090
120NANOG_21062744_ChIP-ChIP_HESCs_Human0.82323468
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79902497
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78693560
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.77490502
124SOX2_16153702_ChIP-ChIP_HESCs_Human0.74213683
125CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.72659557
126* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71526865
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70349712
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.70101768
129* CRX_20693478_ChIP-Seq_RETINA_Mouse0.69216490
130CBP_20019798_ChIP-Seq_JUKART_Human0.69094690
131IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.69094690
132* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.68937547

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.15719818
2MP0004957_abnormal_blastocyst_morpholog4.99237800
3MP0010094_abnormal_chromosome_stability4.48550873
4MP0003111_abnormal_nucleus_morphology4.35691102
5MP0003806_abnormal_nucleotide_metabolis3.95093774
6MP0003077_abnormal_cell_cycle3.92990496
7MP0008058_abnormal_DNA_repair3.48452620
8MP0008932_abnormal_embryonic_tissue3.29163359
9MP0008057_abnormal_DNA_replication3.10079770
10MP0003123_paternal_imprinting2.97994226
11MP0003718_maternal_effect2.95127422
12MP0008877_abnormal_DNA_methylation2.95021492
13MP0008007_abnormal_cellular_replicative2.67443596
14MP0001730_embryonic_growth_arrest2.61360612
15MP0000372_irregular_coat_pigmentation2.53399674
16MP0003786_premature_aging2.50221544
17MP0000350_abnormal_cell_proliferation2.22405166
18MP0010234_abnormal_vibrissa_follicle2.04677835
19MP0005408_hypopigmentation1.99722568
20MP0001697_abnormal_embryo_size1.87846499
21MP0001672_abnormal_embryogenesis/_devel1.82857475
22MP0005380_embryogenesis_phenotype1.82857475
23MP0006036_abnormal_mitochondrial_physio1.77612765
24MP0003186_abnormal_redox_activity1.75780089
25MP0003221_abnormal_cardiomyocyte_apopto1.71922430
26MP0006035_abnormal_mitochondrial_morpho1.70850698
27MP0002080_prenatal_lethality1.66845184
28MP0002102_abnormal_ear_morphology1.66565743
29MP0010352_gastrointestinal_tract_polyps1.66402952
30MP0003984_embryonic_growth_retardation1.64353745
31MP0002088_abnormal_embryonic_growth/wei1.59300877
32MP0003646_muscle_fatigue1.57691920
33MP0003567_abnormal_fetal_cardiomyocyte1.57160206
34MP0002210_abnormal_sex_determination1.52124072
35MP0002877_abnormal_melanocyte_morpholog1.51249862
36MP0002938_white_spotting1.49646086
37MP0005187_abnormal_penis_morphology1.48558083
38MP0004084_abnormal_cardiac_muscle1.47771606
39MP0003890_abnormal_embryonic-extraembry1.47253412
40MP0002085_abnormal_embryonic_tissue1.43909635
41MP0002090_abnormal_vision1.42550910
42MP0000358_abnormal_cell_content/1.41620244
43MP0009697_abnormal_copulation1.38692031
44MP0002084_abnormal_developmental_patter1.36863134
45MP0010307_abnormal_tumor_latency1.35582766
46MP0002254_reproductive_system_inflammat1.35368417
47MP0001145_abnormal_male_reproductive1.33521251
48MP0003315_abnormal_perineum_morphology1.33134856
49MP0008875_abnormal_xenobiotic_pharmacok1.32645647
50MP0002160_abnormal_reproductive_system1.31331079
51MP0000313_abnormal_cell_death1.29179849
52MP0008260_abnormal_autophagy1.28837253
53MP0003195_calcinosis1.28469610
54MP0002086_abnormal_extraembryonic_tissu1.25057102
55MP0004197_abnormal_fetal_growth/weight/1.24870046
56MP0000750_abnormal_muscle_regeneration1.23426041
57MP0010030_abnormal_orbit_morphology1.22672643
58MP0003941_abnormal_skin_development1.22535342
59MP0003950_abnormal_plasma_membrane1.17987442
60MP0010678_abnormal_skin_adnexa1.14189252
61MP0001929_abnormal_gametogenesis1.14106610
62MP0002019_abnormal_tumor_incidence1.13923473
63MP0000647_abnormal_sebaceous_gland1.13387164
64MP0000653_abnormal_sex_gland1.11786238
65MP0005266_abnormal_metabolism1.11339420
66MP0002269_muscular_atrophy1.11321604
67MP0002396_abnormal_hematopoietic_system1.10666229
68MP0005389_reproductive_system_phenotype1.08992899
69MP0006072_abnormal_retinal_apoptosis1.08232549
70MP0005084_abnormal_gallbladder_morpholo1.02780591
71MP0009046_muscle_twitch1.00991220
72MP0003119_abnormal_digestive_system0.99426692
73MP0000427_abnormal_hair_cycle0.97941785
74MP0003121_genomic_imprinting0.97689104
75MP0000015_abnormal_ear_pigmentation0.97407835
76MP0002234_abnormal_pharynx_morphology0.97293152
77MP0000490_abnormal_crypts_of0.94378717
78MP0005395_other_phenotype0.92194217
79MP0000569_abnormal_digit_pigmentation0.91761320
80MP0005253_abnormal_eye_physiology0.91670161
81MP0005075_abnormal_melanosome_morpholog0.91607632
82MP0004147_increased_porphyrin_level0.90917080
83MP0005384_cellular_phenotype0.90413852
84MP0009672_abnormal_birth_weight0.89711878
85MP0009053_abnormal_anal_canal0.89410895
86MP0004133_heterotaxia0.84628242
87MP0000749_muscle_degeneration0.83266925
88MP0001984_abnormal_olfaction0.83091808
89MP0009333_abnormal_splenocyte_physiolog0.82895842
90MP0000371_diluted_coat_color0.80713527
91MP0001119_abnormal_female_reproductive0.80009580
92MP0005670_abnormal_white_adipose0.79950344
93MP0001542_abnormal_bone_strength0.79883291
94MP0001764_abnormal_homeostasis0.78577005
95MP0005551_abnormal_eye_electrophysiolog0.78068280
96MP0005171_absent_coat_pigmentation0.77669120
97MP0000613_abnormal_salivary_gland0.76364830
98MP0005621_abnormal_cell_physiology0.76102253
99MP0001919_abnormal_reproductive_system0.75484860
100MP0002837_dystrophic_cardiac_calcinosis0.75455054
101MP0000383_abnormal_hair_follicle0.75372081
102MP0002970_abnormal_white_adipose0.75088795
103MP0001293_anophthalmia0.74250617
104MP0002111_abnormal_tail_morphology0.74226230
105MP0002653_abnormal_ependyma_morphology0.74043758
106MP0002095_abnormal_skin_pigmentation0.73052963
107MP0006054_spinal_hemorrhage0.71474843
108MP0005367_renal/urinary_system_phenotyp0.70198107
109MP0000516_abnormal_urinary_system0.70198107
110MP0005174_abnormal_tail_pigmentation0.69833963
111MP0001324_abnormal_eye_pigmentation0.68843676
112MP0003136_yellow_coat_color0.68619439
113MP0001529_abnormal_vocalization0.68539800
114MP0003937_abnormal_limbs/digits/tail_de0.67845593
115MP0004215_abnormal_myocardial_fiber0.67744243
116MP0000627_abnormal_mammary_gland0.66107590
117MP0002751_abnormal_autonomic_nervous0.66058200
118MP0001186_pigmentation_phenotype0.65026834
119MP0000537_abnormal_urethra_morphology0.64228035
120MP0000747_muscle_weakness0.63898685
121MP0005330_cardiomyopathy0.63880982
122MP0002127_abnormal_cardiovascular_syste0.63638813
123MP0001727_abnormal_embryo_implantation0.61618144
124MP0003698_abnormal_male_reproductive0.60155888
125MP0005332_abnormal_amino_acid0.59906750
126MP0004808_abnormal_hematopoietic_stem0.58854723
127MP0004036_abnormal_muscle_relaxation0.58568238
128MP0002161_abnormal_fertility/fecundity0.57362242
129MP0003936_abnormal_reproductive_system0.52087568
130MP0003656_abnormal_erythrocyte_physiolo0.50246326
131MP0005376_homeostasis/metabolism_phenot0.50004014
132MP0002332_abnormal_exercise_endurance0.49106877
133MP0005023_abnormal_wound_healing0.48710272
134MP0003699_abnormal_female_reproductive0.48024074
135MP0001286_abnormal_eye_development0.46777133
136MP0002132_abnormal_respiratory_system0.46467710
137MP0005319_abnormal_enzyme/_coenzyme0.45198398
138MP0001661_extended_life_span0.43288408
139MP0000598_abnormal_liver_morphology0.43179890
140MP0009703_decreased_birth_body0.42923302
141MP0001544_abnormal_cardiovascular_syste0.42352930
142MP0005385_cardiovascular_system_phenoty0.42352930

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.36246814
2Breast hypoplasia (HP:0003187)4.16078917
3Carpal bone hypoplasia (HP:0001498)4.07160200
4Cerebral hypomyelination (HP:0006808)3.89391120
5Oral leukoplakia (HP:0002745)3.76191975
6Abnormality of glycolysis (HP:0004366)3.74951488
7Increased serum pyruvate (HP:0003542)3.74951488
8Abnormality of the anterior horn cell (HP:0006802)3.66263483
9Degeneration of anterior horn cells (HP:0002398)3.66263483
10Hepatocellular necrosis (HP:0001404)3.62505703
11Hepatic necrosis (HP:0002605)3.45983220
12Rough bone trabeculation (HP:0100670)3.44110853
13Aplasia/Hypoplasia of the uvula (HP:0010293)3.39881127
14Increased CSF lactate (HP:0002490)3.32171325
15Increased serum lactate (HP:0002151)3.23326804
16Mitochondrial inheritance (HP:0001427)3.19304365
17Patellar aplasia (HP:0006443)3.15175423
18Acute necrotizing encephalopathy (HP:0006965)3.14536457
19Abnormality of cells of the erythroid lineage (HP:0012130)3.10695746
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.09112605
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.09112605
22Abnormal mitochondria in muscle tissue (HP:0008316)3.02130687
23Abnormal lung lobation (HP:0002101)2.99954445
24Aplasia/Hypoplasia of the patella (HP:0006498)2.99044559
25Abnormality of alanine metabolism (HP:0010916)2.94746352
26Hyperalaninemia (HP:0003348)2.94746352
27Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.94746352
28Duodenal stenosis (HP:0100867)2.92208639
29Small intestinal stenosis (HP:0012848)2.92208639
30Aplastic anemia (HP:0001915)2.90753392
31Impulsivity (HP:0100710)2.84497905
32Abnormality of the labia minora (HP:0012880)2.83046907
33Abnormal number of erythroid precursors (HP:0012131)2.81766045
34Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.75462473
35Nephroblastoma (Wilms tumor) (HP:0002667)2.75363474
36Colon cancer (HP:0003003)2.70792191
37CNS demyelination (HP:0007305)2.70362740
38Embryonal renal neoplasm (HP:0011794)2.70002988
39Irregular epiphyses (HP:0010582)2.68233832
40Trismus (HP:0000211)2.66717811
41Reticulocytopenia (HP:0001896)2.65127805
42Volvulus (HP:0002580)2.61277297
43Breast carcinoma (HP:0003002)2.61153924
44Acute encephalopathy (HP:0006846)2.59267448
45Microvesicular hepatic steatosis (HP:0001414)2.59230373
46Absent radius (HP:0003974)2.54596073
47Macrocytic anemia (HP:0001972)2.53500856
48Multiple enchondromatosis (HP:0005701)2.52094880
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.50198019
50Lactic acidosis (HP:0003128)2.49729540
51Selective tooth agenesis (HP:0001592)2.48649018
52Abnormal trabecular bone morphology (HP:0100671)2.47500497
53Secondary amenorrhea (HP:0000869)2.46773879
54Premature ovarian failure (HP:0008209)2.46203971
55Microretrognathia (HP:0000308)2.44130091
56Emotional lability (HP:0000712)2.41936510
57Abnormality of the duodenum (HP:0002246)2.41314557
58Abnormal spermatogenesis (HP:0008669)2.40884234
59Megaloblastic anemia (HP:0001889)2.40224513
60Progressive muscle weakness (HP:0003323)2.40093376
61Type I transferrin isoform profile (HP:0003642)2.39336043
62Increased hepatocellular lipid droplets (HP:0006565)2.38968905
63Absent thumb (HP:0009777)2.37836522
64Absent forearm bone (HP:0003953)2.36646751
65Aplasia involving forearm bones (HP:0009822)2.36646751
66Progressive macrocephaly (HP:0004481)2.36518009
67Atrophy/Degeneration involving motor neurons (HP:0007373)2.34242092
68Exercise intolerance (HP:0003546)2.32402561
69Cerebral edema (HP:0002181)2.32347547
70Neoplasm of the adrenal gland (HP:0100631)2.31443066
71Sloping forehead (HP:0000340)2.30984685
72Neoplasm of the pancreas (HP:0002894)2.30473513
73Respiratory failure (HP:0002878)2.30202820
74Premature graying of hair (HP:0002216)2.29584398
75CNS hypomyelination (HP:0003429)2.26666329
76Reduced antithrombin III activity (HP:0001976)2.26138511
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.25030567
78Abnormal protein N-linked glycosylation (HP:0012347)2.25030567
79Abnormal protein glycosylation (HP:0012346)2.25030567
80Abnormal glycosylation (HP:0012345)2.25030567
81Agnosia (HP:0010524)2.25006649
82Ependymoma (HP:0002888)2.23672968
83Horseshoe kidney (HP:0000085)2.23064769
84Aplasia/Hypoplasia involving the musculature (HP:0001460)2.20934762
85Abnormality of the carotid arteries (HP:0005344)2.20671647
86Hyperglycinemia (HP:0002154)2.20488948
87Lipid accumulation in hepatocytes (HP:0006561)2.20461383
88Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.19912122
89Abnormality of methionine metabolism (HP:0010901)2.19313626
90Shoulder girdle muscle weakness (HP:0003547)2.16769376
91Chromsome breakage (HP:0040012)2.15916410
92Abnormality of serum amino acid levels (HP:0003112)2.15312671
93Postnatal microcephaly (HP:0005484)2.14509360
94Meckel diverticulum (HP:0002245)2.13896643
95Hyperglycinuria (HP:0003108)2.13620507
96Progressive external ophthalmoplegia (HP:0000590)2.12723959
97Medulloblastoma (HP:0002885)2.12715749
98Nausea (HP:0002018)2.12461697
99Myelodysplasia (HP:0002863)2.12093169
100Cellular immunodeficiency (HP:0005374)2.12075695
101Aplasia/Hypoplasia of the tibia (HP:0005772)2.07836759
102Sparse eyelashes (HP:0000653)2.07422930
103Glossoptosis (HP:0000162)2.05764949
104Abnormality of the preputium (HP:0100587)2.04692632
105Abnormality of pyrimidine metabolism (HP:0004353)2.02335333
106Rhabdomyosarcoma (HP:0002859)2.01667314
107Abnormality of chromosome stability (HP:0003220)2.00962394
108Abnormality of glycine metabolism (HP:0010895)2.00712248
109Abnormality of serine family amino acid metabolism (HP:0010894)2.00712248
110Pancreatic cysts (HP:0001737)2.00423642
111Supernumerary spleens (HP:0009799)1.99574723
112Glioma (HP:0009733)1.98984374
113Abnormality of the ileum (HP:0001549)1.98678129
114Abnormality of the umbilical cord (HP:0010881)1.97129240
115Clubbing of toes (HP:0100760)1.96657417
116Unsteady gait (HP:0002317)1.96052583
117Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96018560
118Small hand (HP:0200055)1.93863583
119Rhabdomyolysis (HP:0003201)1.92527648
120Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91469141
121Progressive inability to walk (HP:0002505)1.89195105
122Microglossia (HP:0000171)1.88783379
123Type 2 muscle fiber atrophy (HP:0003554)1.88604135
124Lethargy (HP:0001254)1.88451571
125Stenosis of the external auditory canal (HP:0000402)1.87902079
126Ectopic kidney (HP:0000086)1.87604581
127Muscle fiber atrophy (HP:0100295)1.87537259
128Hypokinesia (HP:0002375)1.86695916
129Pelvic girdle muscle weakness (HP:0003749)1.86616588
130Sensory axonal neuropathy (HP:0003390)1.86580565
131Neoplasm of the colon (HP:0100273)1.86493519
132Increased nuchal translucency (HP:0010880)1.85818257
133Rimmed vacuoles (HP:0003805)1.85207235
134Methylmalonic acidemia (HP:0002912)1.84704316
135Tongue fasciculations (HP:0001308)1.84091968
136Pallor (HP:0000980)1.84065280
137Pancreatic fibrosis (HP:0100732)1.84012907
138Aplasia/hypoplasia of the uterus (HP:0008684)1.82688061
139Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81019451
140Hypoplasia of the uterus (HP:0000013)1.80963840
141Pancreatic islet-cell hyperplasia (HP:0004510)1.79622188
142Poikiloderma (HP:0001029)1.78945006
143Short tibia (HP:0005736)1.77257607
144Choanal atresia (HP:0000453)1.77063961
145True hermaphroditism (HP:0010459)1.73902654
146Neoplasm of the adrenal cortex (HP:0100641)1.69569070
147Adrenal hypoplasia (HP:0000835)1.69271333
148Triphalangeal thumb (HP:0001199)1.69191422
149Horizontal nystagmus (HP:0000666)1.68817815
150Astrocytoma (HP:0009592)1.68453438
151Abnormality of the astrocytes (HP:0100707)1.68453438
152Unilateral renal agenesis (HP:0000122)1.66974970
153Gonadotropin excess (HP:0000837)1.66930703
154Bilateral sensorineural hearing impairment (HP:0008619)1.66212319
155Facial cleft (HP:0002006)1.66155153
156Neuroendocrine neoplasm (HP:0100634)1.65759057
157Ovarian neoplasm (HP:0100615)1.64146007

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.27000982
2EIF2AK14.40165319
3WEE14.39894001
4TSSK63.19289588
5TRIM283.13370120
6CDC73.00908410
7NEK12.90178594
8FRK2.89644097
9ACVR1B2.75440430
10STK162.64870964
11EIF2AK32.64014232
12PLK42.59712869
13WNK32.55302435
14SRPK12.52882239
15NME22.32088500
16BRSK22.03823987
17TTK1.94556551
18EPHA21.92784771
19PNCK1.89273769
20PLK11.87485245
21TESK21.87154747
22ERBB31.83452823
23PLK31.82000108
24PDK31.68340885
25PDK41.68340885
26NEK21.66772705
27PBK1.65440561
28VRK11.59041793
29BMPR1B1.56836230
30NME11.56639430
31MKNK11.50283295
32NUAK11.49858055
33CCNB11.42522875
34STK391.40363267
35AURKA1.38089464
36VRK21.33968702
37AURKB1.32021467
38ZAK1.30928898
39BRSK11.25487001
40SIK31.24198354
41MKNK21.24140110
42LIMK11.23833556
43BCKDK1.21807020
44DYRK31.20937390
45BRAF1.19938009
46STK38L1.18171615
47AKT31.15499535
48TESK11.14965052
49CHEK21.14235814
50RPS6KB21.11005788
51PDK21.10538758
52MAP4K21.09835306
53RPS6KA41.09382675
54ATR1.08969195
55TLK11.07562776
56CDK71.00991861
57MST1R0.95842815
58MAP3K80.92031493
59PASK0.90537733
60CHEK10.89982809
61TAF10.89185279
62OXSR10.88972119
63KDR0.88816384
64TGFBR10.87935413
65FER0.86246142
66MAPKAPK50.84189523
67ERBB40.81048997
68PIM20.80629999
69TNIK0.79872889
70PAK40.78871519
71MAP3K110.76609133
72CSNK2A20.74205293
73CSNK2A10.72661974
74PINK10.70457666
75CSNK1G10.70406582
76SCYL20.69606158
77CDK40.68242461
78CSNK1G20.65074087
79ALK0.64490258
80LATS10.62912828
81LATS20.62389567
82MAP3K30.61825936
83PRKCI0.61628745
84PAK10.60894827
85CSNK1A1L0.60182086
86CDK20.59219646
87MAP2K30.59074869
88STK40.58457364
89EIF2AK20.58044195
90ATM0.56011943
91MAPKAPK30.54997342
92MST40.52792435
93WNK40.52776126
94STK240.52226695
95PLK20.49078019
96BCR0.47220652
97DYRK20.46963306
98ARAF0.46616921
99ABL20.46411302
100FGFR10.45883697
101BRD40.45704065
102CDK10.44677067
103CSNK1E0.43513275
104CLK10.43218671
105GRK10.42497844
106OBSCN0.42457107
107CDK80.42423077
108TAOK20.42132424
109INSRR0.41369214
110MET0.41111201
111YES10.40107631
112MAP2K60.38460601
113MELK0.36112783
114MAP3K40.34693379
115NEK90.34624808
116MAP3K50.34525355
117STK100.33622348
118RPS6KA50.32046019
119ADRBK20.31459402
120MAP2K70.31319582
121MINK10.28172010
122STK30.27147856
123PAK30.26676067
124IRAK30.26317234
125PIM10.26177427
126PRKCE0.25519770
127MAP3K120.23004119
128FLT30.20714614
129ILK0.20664865
130DAPK10.18188287
131CDK120.17279981
132CDK140.14861544
133PRKDC0.14415827
134AKT20.14036449
135CSNK1G30.13598264

Predicted pathways (KEGG)

RankGene SetZ-score
1* Proteasome_Homo sapiens_hsa030504.93341663
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.98621725
3DNA replication_Homo sapiens_hsa030303.90873371
4RNA polymerase_Homo sapiens_hsa030203.52900134
5Mismatch repair_Homo sapiens_hsa034303.47098825
6Ribosome_Homo sapiens_hsa030103.13491586
7RNA transport_Homo sapiens_hsa030133.12624019
8Spliceosome_Homo sapiens_hsa030402.96727672
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.71558259
10Nucleotide excision repair_Homo sapiens_hsa034202.56768553
11Homologous recombination_Homo sapiens_hsa034402.52473437
12Pyrimidine metabolism_Homo sapiens_hsa002402.48448091
13One carbon pool by folate_Homo sapiens_hsa006702.35948489
14Cell cycle_Homo sapiens_hsa041102.23389385
15Base excision repair_Homo sapiens_hsa034102.22467037
16Basal transcription factors_Homo sapiens_hsa030222.00205888
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.95522912
18Parkinsons disease_Homo sapiens_hsa050121.71424547
19Oxidative phosphorylation_Homo sapiens_hsa001901.70823690
20RNA degradation_Homo sapiens_hsa030181.66666664
21Vitamin B6 metabolism_Homo sapiens_hsa007501.61121259
22Fanconi anemia pathway_Homo sapiens_hsa034601.59428302
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.48472756
24Huntingtons disease_Homo sapiens_hsa050161.47946934
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39332149
26Purine metabolism_Homo sapiens_hsa002301.37441539
27Non-homologous end-joining_Homo sapiens_hsa034501.35396989
28Protein export_Homo sapiens_hsa030601.33588101
29Biosynthesis of amino acids_Homo sapiens_hsa012301.32780506
30Folate biosynthesis_Homo sapiens_hsa007901.30713334
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29392120
32Carbon metabolism_Homo sapiens_hsa012001.27972331
33mRNA surveillance pathway_Homo sapiens_hsa030151.27806940
34Steroid biosynthesis_Homo sapiens_hsa001001.20115412
35Pentose phosphate pathway_Homo sapiens_hsa000301.19350729
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18483504
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17250228
38* Epstein-Barr virus infection_Homo sapiens_hsa051691.15388083
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12424970
40p53 signaling pathway_Homo sapiens_hsa041151.11886843
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10711831
42Selenocompound metabolism_Homo sapiens_hsa004501.09130415
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.98740883
44Sulfur metabolism_Homo sapiens_hsa009200.97829673
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95038094
46Oocyte meiosis_Homo sapiens_hsa041140.92064823
47Pyruvate metabolism_Homo sapiens_hsa006200.84627925
48Glutathione metabolism_Homo sapiens_hsa004800.83308551
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.83139310
50Fatty acid metabolism_Homo sapiens_hsa012120.82537087
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81222769
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81081224
53Fructose and mannose metabolism_Homo sapiens_hsa000510.80819904
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79581780
55Sulfur relay system_Homo sapiens_hsa041220.78642386
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77302612
57Alzheimers disease_Homo sapiens_hsa050100.75794487
58Regulation of autophagy_Homo sapiens_hsa041400.72793535
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71987460
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63947632
61Tryptophan metabolism_Homo sapiens_hsa003800.62306637
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60459974
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57748598
64Metabolic pathways_Homo sapiens_hsa011000.57631127
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57408534
66Systemic lupus erythematosus_Homo sapiens_hsa053220.52180554
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51633115
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51488228
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49530700
70Phototransduction_Homo sapiens_hsa047440.48988394
71Antigen processing and presentation_Homo sapiens_hsa046120.48382378
72Thyroid cancer_Homo sapiens_hsa052160.46206351
73Arginine and proline metabolism_Homo sapiens_hsa003300.45487051
74Viral carcinogenesis_Homo sapiens_hsa052030.45290597
75Legionellosis_Homo sapiens_hsa051340.43361257
76Propanoate metabolism_Homo sapiens_hsa006400.42485703
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41680208
78Galactose metabolism_Homo sapiens_hsa000520.36958600
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.36440631
80Herpes simplex infection_Homo sapiens_hsa051680.35126223
81Lysine degradation_Homo sapiens_hsa003100.32972494
82Ether lipid metabolism_Homo sapiens_hsa005650.32148686
83Cardiac muscle contraction_Homo sapiens_hsa042600.31716514
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30738022
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.28878844
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.25131119
87Nitrogen metabolism_Homo sapiens_hsa009100.24706791
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.23866949
89HTLV-I infection_Homo sapiens_hsa051660.23491832
90Caffeine metabolism_Homo sapiens_hsa002320.21807973
91Vitamin digestion and absorption_Homo sapiens_hsa049770.20743305
92Tyrosine metabolism_Homo sapiens_hsa003500.19323931
93Vibrio cholerae infection_Homo sapiens_hsa051100.19180610
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18131650
95Arginine biosynthesis_Homo sapiens_hsa002200.17898451
96Phenylalanine metabolism_Homo sapiens_hsa003600.17786495
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17440564
98Fat digestion and absorption_Homo sapiens_hsa049750.17081610
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16633331
100Fatty acid biosynthesis_Homo sapiens_hsa000610.15767263
101Arachidonic acid metabolism_Homo sapiens_hsa005900.15627236
102Sphingolipid metabolism_Homo sapiens_hsa006000.14649297
103HIF-1 signaling pathway_Homo sapiens_hsa040660.13663867
104Hippo signaling pathway_Homo sapiens_hsa043900.09135906
105beta-Alanine metabolism_Homo sapiens_hsa004100.08879324
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.08722675
107Collecting duct acid secretion_Homo sapiens_hsa049660.08718765
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.06601751
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.06354763
110N-Glycan biosynthesis_Homo sapiens_hsa005100.06328494
111Renin-angiotensin system_Homo sapiens_hsa046140.05433078
112Peroxisome_Homo sapiens_hsa041460.04392598
113Shigellosis_Homo sapiens_hsa051310.03899039
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.02484345
115Fatty acid elongation_Homo sapiens_hsa000620.01740167
116TGF-beta signaling pathway_Homo sapiens_hsa043500.01534976
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.01474649
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.00661861
119Apoptosis_Homo sapiens_hsa04210-0.0299620
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0251019
121Linoleic acid metabolism_Homo sapiens_hsa00591-0.0195653
122Butanoate metabolism_Homo sapiens_hsa00650-0.0188333
123Fatty acid degradation_Homo sapiens_hsa00071-0.0158746

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