ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	histone-serine phosphorylation (GO:0035404)	7.42306363
2	interleukin-6-mediated signaling pathway (GO:0070102)	7.13427593
3	regulation of cell maturation (GO:1903429)	6.66847852
4	histone H3-K4 trimethylation (GO:0080182)	6.53813248
5	protein localization to microtubule cytoskeleton (GO:0072698)	6.12110773
6	neuron fate determination (GO:0048664)	6.00567721
7	positive regulation of oligodendrocyte differentiation (GO:0048714)	5.95400218
8	protein localization to cytoskeleton (GO:0044380)	5.90309945
9	positive regulation of histone H3-K4 methylation (GO:0051571)	5.55256207
10	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	5.51312976
11	DNA deamination (GO:0045006)	5.50336566
12	epithelial cell fate commitment (GO:0072148)	5.49639297
13	regulation of acrosome reaction (GO:0060046)	5.24561266
14	regulation of spindle organization (GO:0090224)	5.21760734
15	histone H2B ubiquitination (GO:0033523)	5.15979286
16	protein K11-linked deubiquitination (GO:0035871)	5.12854478
17	positive regulation of osteoblast proliferation (GO:0033690)	5.05724919
18	positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)	5.04153370
19	regulation of spindle checkpoint (GO:0090231)	5.00993725
20	cell fate commitment involved in formation of primary germ layer (GO:0060795)	4.69131977
21	respiratory chain complex IV assembly (GO:0008535)	4.59634035
22	serotonin receptor signaling pathway (GO:0007210)	4.33221834
23	acrosome reaction (GO:0007340)	4.28836739
24	deoxyribose phosphate biosynthetic process (GO:0046385)	4.27269697
25	2-deoxyribonucleotide biosynthetic process (GO:0009265)	4.27269697
26	peptidyl-lysine trimethylation (GO:0018023)	4.22128643
27	detection of light stimulus involved in visual perception (GO:0050908)	4.15025440
28	detection of light stimulus involved in sensory perception (GO:0050962)	4.15025440
29	regulation of gene expression by genetic imprinting (GO:0006349)	4.10361265
30	negative regulation of transcription regulatory region DNA binding (GO:2000678)	4.09138143
31	spinal cord motor neuron differentiation (GO:0021522)	4.08095417
32	positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)	4.03602791
33	cytochrome complex assembly (GO:0017004)	4.03586964
34	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	3.97751237
35	sulfate transport (GO:0008272)	3.94227319
36	regulation of oligodendrocyte differentiation (GO:0048713)	3.90167881
37	urinary tract smooth muscle contraction (GO:0014848)	3.87105290
38	reciprocal meiotic recombination (GO:0007131)	3.82881928
39	reciprocal DNA recombination (GO:0035825)	3.82881928
40	type B pancreatic cell development (GO:0003323)	3.81941319
41	positive regulation of DNA-templated transcription, initiation (GO:2000144)	3.76247009
42	rRNA modification (GO:0000154)	3.76025910
43	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	3.72318386
44	granulocyte differentiation (GO:0030851)	3.67170656
45	spliceosomal complex assembly (GO:0000245)	3.61061298
46	proline transport (GO:0015824)	3.57785406
47	sulfate transmembrane transport (GO:1902358)	3.53692558
48	regulation of centrosome cycle (GO:0046605)	3.52839777
49	negative regulation of mast cell activation (GO:0033004)	3.49728925
50	centrosome localization (GO:0051642)	3.49187012
51	positive regulation of glial cell differentiation (GO:0045687)	3.46798429
52	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.45398077
53	NADH dehydrogenase complex assembly (GO:0010257)	3.45398077
54	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.45398077
55	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.44716808
56	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.43645078
57	negative regulation of circadian rhythm (GO:0042754)	3.43213547
58	glycine transport (GO:0015816)	3.37679949
59	lymphangiogenesis (GO:0001946)	3.35134629
60	erythrocyte development (GO:0048821)	3.34480111
61	histone H3-K4 methylation (GO:0051568)	3.34392895
62	astrocyte differentiation (GO:0048708)	3.32935120
63	intestinal epithelial cell development (GO:0060576)	3.31974888
64	cellular response to interleukin-6 (GO:0071354)	3.26380273
65	cellular ketone body metabolic process (GO:0046950)	3.25667314
66	response to folic acid (GO:0051593)	3.25364937
67	artery development (GO:0060840)	3.24444683
68	single strand break repair (GO:0000012)	3.21614557
69	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.13984724
70	peptidyl-lysine methylation (GO:0018022)	3.11868560
71	pseudouridine synthesis (GO:0001522)	3.09228263
72	adult feeding behavior (GO:0008343)	3.05611378
73	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.03896620
74	replication fork processing (GO:0031297)	3.03653610
75	maturation of 5.8S rRNA (GO:0000460)	3.03086124
76	spindle assembly (GO:0051225)	3.02469981
77	DNA double-strand break processing (GO:0000729)	3.00532123
78	protein complex biogenesis (GO:0070271)	2.98367554
79	DNA strand renaturation (GO:0000733)	2.97996883
80	deoxyribonucleotide biosynthetic process (GO:0009263)	2.97522535
81	sensory perception of taste (GO:0050909)	2.91807609
82	kinetochore assembly (GO:0051382)	2.90922357
83	ketone body metabolic process (GO:1902224)	2.88680355
84	establishment of protein localization to Golgi (GO:0072600)	2.86716978
85	protein deneddylation (GO:0000338)	2.84911571
86	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.82347662
87	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.82089169
88	rRNA catabolic process (GO:0016075)	2.81414042
89	rRNA methylation (GO:0031167)	2.80121342
90	protein-cofactor linkage (GO:0018065)	2.79298503
91	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.76408555
92	positive regulation of T cell cytokine production (GO:0002726)	2.75990185
93	mitotic spindle organization (GO:0007052)	2.75172679
94	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.74327720
95	cytidine metabolic process (GO:0046087)	2.74194089
96	cytidine catabolic process (GO:0006216)	2.74194089
97	cytidine deamination (GO:0009972)	2.74194089
98	genetic imprinting (GO:0071514)	2.73453528
99	negative regulation of keratinocyte proliferation (GO:0010839)	2.73411402
100	histone phosphorylation (GO:0016572)	2.69591731

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.55013763
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	4.21365407
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.93294137
4	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.45647004
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.27115543
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.23525685
7	VDR_22108803_ChIP-Seq_LS180_Human	3.20228588
8	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.26777496
9	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.26070814
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.23052076
11	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.19436993
12	EWS_26573619_Chip-Seq_HEK293_Human	2.15142009
13	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.06582913
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.06253799
15	AR_21572438_ChIP-Seq_LNCaP_Human	2.05156507
16	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.04061803
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.90261675
18	TP53_22573176_ChIP-Seq_HFKS_Human	1.89212481
19	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.88860612
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.85110967
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.81503906
22	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.80724839
23	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.77905651
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.73928506
25	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.72711406
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.68942343
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.68670650
28	GBX2_23144817_ChIP-Seq_PC3_Human	1.64866388
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.63616726
30	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.57757991
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.55590065
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.53457732
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.53124747
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.52097124
35	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.51548706
36	P300_19829295_ChIP-Seq_ESCs_Human	1.48428264
37	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.46142521
38	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.46142521
39	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.43705075
40	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.40728975
41	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.35469554
42	TCF4_22108803_ChIP-Seq_LS180_Human	1.35258482
43	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.35044419
44	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.33467975
45	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.32964249
46	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.28996109
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26260737
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.26260737
49	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.24617255
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.24608771
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24191700
52	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.23642783
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.22719579
54	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.20833806
55	TCF4_23295773_ChIP-Seq_U87_Human	1.20058947
56	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.18864492
57	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.18571453
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17063406
59	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.16760919
60	EZH2_22144423_ChIP-Seq_EOC_Human	1.10279462
61	JUN_21703547_ChIP-Seq_K562_Human	1.10024700
62	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.09989782
63	VDR_23849224_ChIP-Seq_CD4+_Human	1.09635845
64	IRF1_19129219_ChIP-ChIP_H3396_Human	1.07641395
65	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.07236175
66	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.06598532
67	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.04947922
68	AR_25329375_ChIP-Seq_VCAP_Human	1.03387614
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02940376
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02940376
71	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.02367688
72	FUS_26573619_Chip-Seq_HEK293_Human	1.01298952
73	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.00569378
74	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.99318687
75	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98521713
76	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.97871443
77	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.97868766
78	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97610250
79	STAT3_23295773_ChIP-Seq_U87_Human	0.96268081
80	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.95754083
81	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.95609707
82	MYC_19829295_ChIP-Seq_ESCs_Human	0.94313397
83	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.94117246
84	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.93968648
85	GATA3_26560356_Chip-Seq_TH1_Human	0.93900734
86	HOXB7_26014856_ChIP-Seq_BT474_Human	0.93661903
87	ERA_21632823_ChIP-Seq_H3396_Human	0.93367475
88	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.92658829
89	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.92590268
90	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.92171621
91	FOXP3_21729870_ChIP-Seq_TREG_Human	0.90236168
92	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.90116296
93	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.89504117
94	ERG_20517297_ChIP-Seq_VCAP_Human	0.88668046
95	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.87824276
96	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.87541266
97	ER_23166858_ChIP-Seq_MCF-7_Human	0.86754842
98	NCOR_22424771_ChIP-Seq_293T_Human	0.86187610
99	SMAD4_21799915_ChIP-Seq_A2780_Human	0.84397079
100	E2F1_20622854_ChIP-Seq_HELA_Human	0.83791751

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	5.13280184
2	MP0008057_abnormal_DNA_replication	5.13017159
3	MP0003787_abnormal_imprinting	4.94277289
4	MP0008877_abnormal_DNA_methylation	4.18102758
5	MP0002132_abnormal_respiratory_system	3.93980213
6	MP0003183_abnormal_peptide_metabolism	3.38944680
7	MP0006292_abnormal_olfactory_placode	3.07496743
8	MP0009780_abnormal_chondrocyte_physiolo	2.92165163
9	MP0005360_urolithiasis	2.71898757
10	MP0003195_calcinosis	2.49782753
11	MP0001968_abnormal_touch/_nociception	2.45966100
12	MP0006276_abnormal_autonomic_nervous	2.25335750
13	MP0003111_abnormal_nucleus_morphology	2.23684139
14	MP0010094_abnormal_chromosome_stability	2.23567755
15	MP0003878_abnormal_ear_physiology	2.16098287
16	MP0005377_hearing/vestibular/ear_phenot	2.16098287
17	MP0002736_abnormal_nociception_after	2.10047262
18	MP0008875_abnormal_xenobiotic_pharmacok	1.78033901
19	MP0004885_abnormal_endolymph	1.76357474
20	MP0005551_abnormal_eye_electrophysiolog	1.71349734
21	MP0000383_abnormal_hair_follicle	1.71255375
22	MP0010678_abnormal_skin_adnexa	1.68331168
23	MP0003880_abnormal_central_pattern	1.66281148
24	MP0002102_abnormal_ear_morphology	1.65643100
25	MP0006036_abnormal_mitochondrial_physio	1.65557625
26	MP0002277_abnormal_respiratory_mucosa	1.62997448
27	MP0003077_abnormal_cell_cycle	1.57316911
28	MP0002735_abnormal_chemical_nociception	1.56148462
29	MP0003136_yellow_coat_color	1.54272293
30	MP0003252_abnormal_bile_duct	1.51618753
31	MP0006072_abnormal_retinal_apoptosis	1.50579696
32	MP0010234_abnormal_vibrissa_follicle	1.48085423
33	MP0001661_extended_life_span	1.40117918
34	MP0008872_abnormal_physiological_respon	1.38408559
35	MP0002138_abnormal_hepatobiliary_system	1.38318432
36	MP0003121_genomic_imprinting	1.33715767
37	MP0000569_abnormal_digit_pigmentation	1.31903611
38	MP0009697_abnormal_copulation	1.31652769
39	MP0001919_abnormal_reproductive_system	1.26679361
40	MP0001485_abnormal_pinna_reflex	1.25929404
41	MP0005365_abnormal_bile_salt	1.24925845
42	MP0003122_maternal_imprinting	1.22483187
43	MP0002127_abnormal_cardiovascular_syste	1.20103175
44	MP0008007_abnormal_cellular_replicative	1.19676747
45	MP0000678_abnormal_parathyroid_gland	1.15546407
46	MP0005646_abnormal_pituitary_gland	1.09644492
47	MP0005389_reproductive_system_phenotype	1.09294471
48	MP0003950_abnormal_plasma_membrane	1.08500425
49	MP0003045_fibrosis	1.05575808
50	MP0000372_irregular_coat_pigmentation	1.04622835
51	MP0002163_abnormal_gland_morphology	1.00971376
52	MP0001764_abnormal_homeostasis	1.00671931
53	MP0005636_abnormal_mineral_homeostasis	0.98916818
54	MP0005671_abnormal_response_to	0.96639996
55	MP0001879_abnormal_lymphatic_vessel	0.95402540
56	MP0009053_abnormal_anal_canal	0.94541609
57	MP0005386_behavior/neurological_phenoty	0.94261533
58	MP0004924_abnormal_behavior	0.94261533
59	MP0002254_reproductive_system_inflammat	0.90572545
60	MP0001188_hyperpigmentation	0.86614354
61	MP0002098_abnormal_vibrissa_morphology	0.84254542
62	MP0002160_abnormal_reproductive_system	0.84162302
63	MP0002234_abnormal_pharynx_morphology	0.83444968
64	MP0001486_abnormal_startle_reflex	0.77771094
65	MP0005253_abnormal_eye_physiology	0.75611720
66	MP0000427_abnormal_hair_cycle	0.71683837
67	MP0005647_abnormal_sex_gland	0.71293905
68	MP0005187_abnormal_penis_morphology	0.70973541
69	MP0009046_muscle_twitch	0.70486906
70	MP0000631_abnormal_neuroendocrine_gland	0.70387339
71	MP0002751_abnormal_autonomic_nervous	0.69979471
72	MP0003718_maternal_effect	0.68555956
73	MP0001502_abnormal_circadian_rhythm	0.64638569
74	MP0001929_abnormal_gametogenesis	0.63289958
75	MP0002168_other_aberrant_phenotype	0.63232295
76	MP0000653_abnormal_sex_gland	0.62997570
77	MP0009745_abnormal_behavioral_response	0.62737536
78	MP0003698_abnormal_male_reproductive	0.61663401
79	MP0005084_abnormal_gallbladder_morpholo	0.60933266
80	MP0009672_abnormal_birth_weight	0.60502193
81	MP0002210_abnormal_sex_determination	0.60429537
82	MP0003806_abnormal_nucleotide_metabolis	0.58640476
83	MP0001663_abnormal_digestive_system	0.58614403
84	MP0002572_abnormal_emotion/affect_behav	0.58322350
85	MP0005395_other_phenotype	0.56838638
86	MP0001765_abnormal_ion_homeostasis	0.56553704
87	MP0000428_abnormal_craniofacial_morphol	0.54919285
88	MP0003936_abnormal_reproductive_system	0.54139723
89	MP0005195_abnormal_posterior_eye	0.53847605
90	MP0002063_abnormal_learning/memory/cond	0.53819871
91	MP0006035_abnormal_mitochondrial_morpho	0.52341328
92	MP0003137_abnormal_impulse_conducting	0.52257414
93	MP0002111_abnormal_tail_morphology	0.50737941
94	MP0003119_abnormal_digestive_system	0.50248762
95	MP0003638_abnormal_response/metabolism_	0.49918569
96	MP0001697_abnormal_embryo_size	0.49836191
97	MP0000313_abnormal_cell_death	0.49423771
98	MP0001324_abnormal_eye_pigmentation	0.49419948
99	MP0002064_seizures	0.49186838
100	MP0001145_abnormal_male_reproductive	0.48655312

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Short middle phalanx of the 5th finger (HP:0004220)	4.63774591
2	Volvulus (HP:0002580)	4.48467551
3	Constricted visual fields (HP:0001133)	4.09941346
4	Acute necrotizing encephalopathy (HP:0006965)	3.83569610
5	Dry hair (HP:0011359)	3.74174274
6	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	3.66752910
7	Acanthocytosis (HP:0001927)	3.58723571
8	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	3.52796404
9	Short 1st metacarpal (HP:0010034)	3.52796404
10	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	3.47540518
11	Abnormality of the phalanges of the 5th finger (HP:0004213)	3.32757292
12	Progressive macrocephaly (HP:0004481)	3.28890721
13	Acute encephalopathy (HP:0006846)	3.23048200
14	Abnormal mitochondria in muscle tissue (HP:0008316)	3.18121085
15	Optic disc pallor (HP:0000543)	3.15647762
16	Abnormality of the 1st metacarpal (HP:0010009)	3.12932752
17	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	3.09479996
18	Decreased circulating renin level (HP:0003351)	3.04734469
19	Bony spicule pigmentary retinopathy (HP:0007737)	3.04667702
20	Cerebral edema (HP:0002181)	3.03805515
21	Short middle phalanx of finger (HP:0005819)	2.96134856
22	Abnormality of proline metabolism (HP:0010907)	2.91248232
23	Hydroxyprolinuria (HP:0003080)	2.91248232
24	Mitochondrial inheritance (HP:0001427)	2.89545567
25	Short 5th finger (HP:0009237)	2.88610353
26	Increased CSF lactate (HP:0002490)	2.87296864
27	Hypoplastic iliac wings (HP:0002866)	2.86211346
28	Hepatic necrosis (HP:0002605)	2.84475537
29	Chronic bronchitis (HP:0004469)	2.79950730
30	Hyperglycinuria (HP:0003108)	2.76969745
31	Confusion (HP:0001289)	2.71948318
32	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	2.70055960
33	Hepatocellular necrosis (HP:0001404)	2.64823376
34	Generalized aminoaciduria (HP:0002909)	2.63661543
35	Intrahepatic cholestasis (HP:0001406)	2.63530193
36	Truncal obesity (HP:0001956)	2.57534086
37	Optic nerve hypoplasia (HP:0000609)	2.55584712
38	Abnormality of the labia minora (HP:0012880)	2.55101533
39	Neoplasm of the tracheobronchial system (HP:0100552)	2.54472127
40	Broad palm (HP:0001169)	2.51462925
41	Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)	2.38608848
42	Autoimmune thrombocytopenia (HP:0001973)	2.33524458
43	Radial bowing (HP:0002986)	2.30782127
44	Hypokalemic alkalosis (HP:0001949)	2.30558081
45	Hypoplastic ischia (HP:0003175)	2.30226236
46	Hypotrichosis (HP:0001006)	2.29862896
47	Abnormal number of incisors (HP:0011064)	2.29700080
48	Abolished electroretinogram (ERG) (HP:0000550)	2.29335893
49	Long clavicles (HP:0000890)	2.26973503
50	Proximal placement of thumb (HP:0009623)	2.26614971
51	Hyperactive renin-angiotensin system (HP:0000841)	2.20594135
52	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.19693689
53	Poikilocytosis (HP:0004447)	2.18206222
54	Short phalanx of the thumb (HP:0009660)	2.17312781
55	Atrioventricular canal defect (HP:0006695)	2.16259469
56	Pendular nystagmus (HP:0012043)	2.15293235
57	Progressive inability to walk (HP:0002505)	2.15041632
58	Decreased central vision (HP:0007663)	2.13880983
59	Hyperkalemia (HP:0002153)	2.12800229
60	Abnormality of the prostate (HP:0008775)	2.09960577
61	Abnormality of the middle phalanges of the hand (HP:0009833)	2.09581527
62	Abnormality of dental color (HP:0011073)	2.07924987
63	Septo-optic dysplasia (HP:0100842)	2.07593288
64	Abnormality of the renal collecting system (HP:0004742)	2.04981800
65	Delayed puberty (HP:0000823)	2.04005154
66	Attenuation of retinal blood vessels (HP:0007843)	2.03898126
67	True hermaphroditism (HP:0010459)	2.03692546
68	Congenital stationary night blindness (HP:0007642)	2.02922420
69	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.02838326
70	Poor speech (HP:0002465)	2.02835087
71	Abnormality of serine family amino acid metabolism (HP:0010894)	2.02272027
72	Abnormality of glycine metabolism (HP:0010895)	2.02272027
73	Duodenal stenosis (HP:0100867)	2.01208373
74	Small intestinal stenosis (HP:0012848)	2.01208373
75	Pancreatic cysts (HP:0001737)	2.01195691
76	Slow-growing hair (HP:0002217)	1.99783568
77	Abnormality of hair growth rate (HP:0011363)	1.99783568
78	Increased nuchal translucency (HP:0010880)	1.98768578
79	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.98429720
80	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.97449484
81	IgG deficiency (HP:0004315)	1.95790738
82	Petechiae (HP:0000967)	1.95065297
83	Neoplasm of the adrenal cortex (HP:0100641)	1.94848717
84	Abnormality of renin-angiotensin system (HP:0000847)	1.92536905
85	Birth length less than 3rd percentile (HP:0003561)	1.91780540
86	Blepharitis (HP:0000498)	1.89799758
87	Impulsivity (HP:0100710)	1.89682355
88	Mesangial abnormality (HP:0001966)	1.88606648
89	Lissencephaly (HP:0001339)	1.87268302
90	Abnormality of cochlea (HP:0000375)	1.82505409
91	Abnormality of the duodenum (HP:0002246)	1.81507818
92	Supernumerary bones of the axial skeleton (HP:0009144)	1.80440641
93	Deep palmar crease (HP:0006191)	1.79711462
94	Ectopic kidney (HP:0000086)	1.79474141
95	X-linked dominant inheritance (HP:0001423)	1.78576525
96	Duplicated collecting system (HP:0000081)	1.76723468
97	Abnormality of the ischium (HP:0003174)	1.75511728
98	Deviation of the thumb (HP:0009603)	1.74805410
99	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.69444627
100	Renal cortical cysts (HP:0000803)	1.69192928

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAF1	4.86935568
2	MARK1	4.50641716
3	CASK	3.43423691
4	PIK3CG	2.23513087
5	FRK	2.19755646
6	VRK2	2.05652186
7	PNCK	2.03714060
8	MAP3K9	11.9357322
9	MAP3K13	1.70245014
10	MST4	1.68885561
11	TNIK	1.59328179
12	ARAF	1.56540725
13	TXK	1.38294182
14	PDK2	1.37976598
15	GRK1	1.27612595
16	OXSR1	1.20177487
17	BUB1	1.17870485
18	EIF2AK1	1.17636647
19	MAPKAPK3	1.11836010
20	MAPKAPK5	1.07628000
21	ZAK	1.06547961
22	NUAK1	1.03241848
23	EIF2AK3	1.02130705
24	BRAF	1.00897300
25	WNK4	0.98249146
26	CDK12	0.97929981
27	AKT3	0.97441020
28	TSSK6	0.90147039
29	EEF2K	0.86069736
30	WNK3	0.86048197
31	STK39	0.85122179
32	AURKA	0.84151059
33	NTRK2	0.80807403
34	TLK1	0.76690967
35	MAP4K2	0.74765504
36	MATK	0.72775435
37	CHEK2	0.71590282
38	DDR2	0.69167591
39	MOS	0.62353776
40	AURKB	0.59829258
41	CDK8	0.58018451
42	INSRR	0.57440080
43	VRK1	0.55567266
44	NTRK3	0.52332240
45	TRIM28	0.51329379
46	ADRBK2	0.50339565
47	DYRK2	0.48456480
48	NEK9	0.44933556
49	CAMK1G	0.44898697
50	SGK2	0.43651247
51	RPS6KB1	0.43634412
52	CDK9	0.43572765
53	BCKDK	0.43314269
54	DAPK1	0.41325880
55	PAK1	0.41096089
56	PBK	0.38437799
57	PINK1	0.36504228
58	TYRO3	0.33997870
59	MAP2K1	0.33774518
60	TAOK3	0.32930763
61	SMG1	0.32805808
62	NLK	0.32086363
63	PLK1	0.31666211
64	MAPK4	0.31351064
65	EIF2AK2	0.31013974
66	TTK	0.29481363
67	CSNK2A2	0.29086776
68	KSR2	0.28570068
69	CSNK1E	0.28530408
70	ATM	0.27830078
71	ACVR1B	0.25400209
72	CHEK1	0.25028876
73	DYRK3	0.25028874
74	TEC	0.24703452
75	EPHA4	0.23969649
76	PRKCH	0.23731292
77	KSR1	0.23269008
78	ATR	0.21865881
79	PLK3	0.21854163
80	CDK7	0.19788919
81	GRK5	0.19541783
82	PRKCG	0.19365176
83	CDK11A	0.17173716
84	GSK3B	0.17003036
85	PRKG1	0.16959646
86	GRK6	0.16645508
87	RPS6KA3	0.16218386
88	CDK18	0.15350064
89	MKNK1	0.13423022
90	PDPK1	0.13393949
91	CDK15	0.12547201
92	RAF1	0.11974271
93	PRKCB	0.11805736
94	CSNK2A1	0.11597794
95	CSNK1A1L	0.11030183
96	SGK494	0.10717522
97	SGK223	0.10717522
98	PRKDC	0.09897419
99	RPS6KB2	0.09831128
100	PLK4	0.09557203

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.80572546
2	Basal transcription factors_Homo sapiens_hsa03022	3.73401946
3	One carbon pool by folate_Homo sapiens_hsa00670	3.54138689
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.19675928
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.96243086
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.90634206
7	Proteasome_Homo sapiens_hsa03050	2.51270318
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.49275552
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.36006423
10	Phototransduction_Homo sapiens_hsa04744	2.24882802
11	Homologous recombination_Homo sapiens_hsa03440	2.15008170
12	Parkinsons disease_Homo sapiens_hsa05012	2.03317676
13	RNA degradation_Homo sapiens_hsa03018	2.02037032
14	RNA transport_Homo sapiens_hsa03013	1.95374633
15	Propanoate metabolism_Homo sapiens_hsa00640	1.94419102
16	Butanoate metabolism_Homo sapiens_hsa00650	1.79947062
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.78935905
18	Taste transduction_Homo sapiens_hsa04742	1.76365642
19	Huntingtons disease_Homo sapiens_hsa05016	1.70989980
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.70146774
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.69716824
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.68855018
23	RNA polymerase_Homo sapiens_hsa03020	1.68237583
24	Primary immunodeficiency_Homo sapiens_hsa05340	1.67301951
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.59555427
26	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.54127343
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.51572296
28	Spliceosome_Homo sapiens_hsa03040	1.48313118
29	Alzheimers disease_Homo sapiens_hsa05010	1.40186091
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.32481335
31	Pyruvate metabolism_Homo sapiens_hsa00620	1.26657777
32	Olfactory transduction_Homo sapiens_hsa04740	1.26630007
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.25714914
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.21812788
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.17682288
36	Cell cycle_Homo sapiens_hsa04110	1.13015503
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.11331630
38	Nicotine addiction_Homo sapiens_hsa05033	1.10527992
39	Glycerolipid metabolism_Homo sapiens_hsa00561	1.07719474
40	Serotonergic synapse_Homo sapiens_hsa04726	1.06727423
41	Fanconi anemia pathway_Homo sapiens_hsa03460	1.06525145
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.03543333
43	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.02420905
44	Ether lipid metabolism_Homo sapiens_hsa00565	1.00372352
45	Base excision repair_Homo sapiens_hsa03410	0.97393986
46	DNA replication_Homo sapiens_hsa03030	0.92588131
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90998890
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90602577
49	Oocyte meiosis_Homo sapiens_hsa04114	0.87477056
50	Morphine addiction_Homo sapiens_hsa05032	0.83197424
51	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.80285035
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80013779
53	Glutathione metabolism_Homo sapiens_hsa00480	0.76902595
54	Cardiac muscle contraction_Homo sapiens_hsa04260	0.75731863
55	Histidine metabolism_Homo sapiens_hsa00340	0.74491989
56	Ribosome_Homo sapiens_hsa03010	0.73618278
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.72382368
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.68208533
59	Purine metabolism_Homo sapiens_hsa00230	0.67971768
60	Mineral absorption_Homo sapiens_hsa04978	0.67671271
61	Sulfur metabolism_Homo sapiens_hsa00920	0.62635301
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.59249716
63	Basal cell carcinoma_Homo sapiens_hsa05217	0.59063623
64	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.58962783
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.56683264
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.55247423
67	Retinol metabolism_Homo sapiens_hsa00830	0.55037351
68	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.54605815
69	Lysine degradation_Homo sapiens_hsa00310	0.53447137
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50645555
71	Non-homologous end-joining_Homo sapiens_hsa03450	0.48868185
72	GABAergic synapse_Homo sapiens_hsa04727	0.48463756
73	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.48132569
74	Calcium signaling pathway_Homo sapiens_hsa04020	0.44846987
75	Metabolic pathways_Homo sapiens_hsa01100	0.44771705
76	Salivary secretion_Homo sapiens_hsa04970	0.43923937
77	Mismatch repair_Homo sapiens_hsa03430	0.42922435
78	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.42872890
79	p53 signaling pathway_Homo sapiens_hsa04115	0.40336130
80	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.40134310
81	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.38537336
82	Prion diseases_Homo sapiens_hsa05020	0.38516812
83	Asthma_Homo sapiens_hsa05310	0.36289392
84	Fatty acid degradation_Homo sapiens_hsa00071	0.33683635
85	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.31732889
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.30288311
87	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.28639471
88	Nucleotide excision repair_Homo sapiens_hsa03420	0.28425036
89	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.28049448
90	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.26289628
91	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.25890021
92	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.25116245
93	Circadian entrainment_Homo sapiens_hsa04713	0.24203527
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.21543769
95	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.20992727
96	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.20899342
97	Thyroid cancer_Homo sapiens_hsa05216	0.20730594
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.18985001
99	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.18870099
100	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.15729023

PSMD12P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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