PSMD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.27683489
2nuclear pore complex assembly (GO:0051292)5.08641002
3DNA unwinding involved in DNA replication (GO:0006268)5.05815580
4mitotic nuclear envelope disassembly (GO:0007077)4.54837482
5DNA replication-dependent nucleosome organization (GO:0034723)4.54632999
6DNA replication-dependent nucleosome assembly (GO:0006335)4.54632999
7establishment of integrated proviral latency (GO:0075713)4.51358563
8regulation of translational termination (GO:0006449)4.44541180
9folic acid-containing compound biosynthetic process (GO:0009396)4.44448659
10IMP biosynthetic process (GO:0006188)4.43874371
11nuclear envelope disassembly (GO:0051081)4.34975677
12membrane disassembly (GO:0030397)4.34975677
13COPI coating of Golgi vesicle (GO:0048205)4.27351281
14Golgi transport vesicle coating (GO:0048200)4.27351281
15nucleobase biosynthetic process (GO:0046112)4.19718524
16protein localization to kinetochore (GO:0034501)4.18723353
17protein maturation by protein folding (GO:0022417)4.18272002
18mitotic chromosome condensation (GO:0007076)4.04442351
19regulation of translational fidelity (GO:0006450)4.03282205
20establishment of viral latency (GO:0019043)4.02741538
21heterochromatin organization (GO:0070828)3.98466949
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.93652393
23formation of translation preinitiation complex (GO:0001731)3.90403343
24mitotic nuclear envelope reassembly (GO:0007084)3.88146070
25nuclear envelope reassembly (GO:0031468)3.88146070
26piRNA metabolic process (GO:0034587)3.86894204
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.84785879
28pore complex assembly (GO:0046931)3.81942792
29IMP metabolic process (GO:0046040)3.77753586
30DNA strand elongation involved in DNA replication (GO:0006271)3.77364940
31protein retention in ER lumen (GO:0006621)3.71254584
32purine nucleobase biosynthetic process (GO:0009113)3.69635165
33hemidesmosome assembly (GO:0031581)3.66258940
34spliceosomal tri-snRNP complex assembly (GO:0000244)3.61628372
35chaperone-mediated protein complex assembly (GO:0051131)3.59667017
36nucleobase-containing small molecule interconversion (GO:0015949)3.59126958
37peptidyl-arginine omega-N-methylation (GO:0035247)3.58928383
38retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.58183178
39regulation of gene silencing by RNA (GO:0060966)3.53483480
40regulation of posttranscriptional gene silencing (GO:0060147)3.53483480
41regulation of gene silencing by miRNA (GO:0060964)3.53483480
42mitotic sister chromatid segregation (GO:0000070)3.52590743
43DNA strand elongation (GO:0022616)3.52385543
44DNA replication initiation (GO:0006270)3.50059161
45synaptonemal complex assembly (GO:0007130)3.49811328
46nuclear envelope organization (GO:0006998)3.49693099
47sister chromatid segregation (GO:0000819)3.47497382
48proline biosynthetic process (GO:0006561)3.47443342
49cell adhesion mediated by integrin (GO:0033627)3.45881868
50protein localization to chromosome, centromeric region (GO:0071459)3.43720731
51postreplication repair (GO:0006301)3.42133688
52ribosome assembly (GO:0042255)3.40620588
53DNA duplex unwinding (GO:0032508)3.38490912
54DNA geometric change (GO:0032392)3.38017849
55gene silencing by RNA (GO:0031047)3.34322932
56regulation of spindle organization (GO:0090224)3.30260544
57protein complex localization (GO:0031503)3.24448521
58histone arginine methylation (GO:0034969)3.20536905
59mitotic metaphase plate congression (GO:0007080)3.18914465
60synaptonemal complex organization (GO:0070193)3.18183415
61translesion synthesis (GO:0019985)3.17851107
62chromosome condensation (GO:0030261)3.12917040
63peptidyl-arginine N-methylation (GO:0035246)3.11849730
64peptidyl-arginine methylation (GO:0018216)3.11849730
65regulation of chromosome segregation (GO:0051983)3.11776294
66protein localization to endosome (GO:0036010)3.08777732
67mitotic G1 DNA damage checkpoint (GO:0031571)3.07649607
68regulation of centrosome cycle (GO:0046605)3.03546202
69peptidyl-lysine dimethylation (GO:0018027)3.03536788
70chromatin assembly (GO:0031497)3.02961181
71regulation of mitotic spindle organization (GO:0060236)3.02329320
72negative regulation of chromosome segregation (GO:0051985)3.00471533
73cellular protein complex localization (GO:0034629)2.99696375
74establishment of chromosome localization (GO:0051303)2.97419922
75negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.97175146
76positive regulation of chromosome segregation (GO:0051984)2.96568729
77mitotic spindle assembly checkpoint (GO:0007094)2.96176336
78negative regulation of mitotic sister chromatid separation (GO:2000816)2.96165199
79negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96165199
80negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96165199
81negative regulation of sister chromatid segregation (GO:0033046)2.96165199
82spindle assembly checkpoint (GO:0071173)2.91921198
83attachment of spindle microtubules to kinetochore (GO:0008608)2.91316392
84paraxial mesoderm development (GO:0048339)2.90687731
85tRNA aminoacylation for protein translation (GO:0006418)2.90664780
86skin morphogenesis (GO:0043589)2.90147940
87cell-substrate junction assembly (GO:0007044)2.88390808
88DNA conformation change (GO:0071103)2.88321998
89regulation of centriole replication (GO:0046599)2.88072636
90dosage compensation (GO:0007549)2.88063274
91* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87927743
92mitotic spindle checkpoint (GO:0071174)2.86671393
93pre-miRNA processing (GO:0031054)2.86368768
94telomere maintenance via semi-conservative replication (GO:0032201)2.84154861
95negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.83695423
96regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.82691832
97DNA replication checkpoint (GO:0000076)2.81841611
98regulation of mitotic metaphase/anaphase transition (GO:0030071)2.80658164
99gene silencing (GO:0016458)2.80408259
100amino acid activation (GO:0043038)2.80376324
101tRNA aminoacylation (GO:0043039)2.80376324
102mRNA transport (GO:0051028)2.80002532
103ribosome biogenesis (GO:0042254)2.79654524
104mitotic cytokinesis (GO:0000281)2.79373970
105pentose-phosphate shunt (GO:0006098)2.79192115
106DNA packaging (GO:0006323)2.79062360
107spindle checkpoint (GO:0031577)2.78366776
108de novo protein folding (GO:0006458)2.78134191
109de novo posttranslational protein folding (GO:0051084)2.76675451
110regulation of DNA damage checkpoint (GO:2000001)2.76487345
111vesicle coating (GO:0006901)2.73141718
112regulation of histone H3-K9 methylation (GO:0051570)2.73097550
113regulation of mammary gland epithelial cell proliferation (GO:0033599)2.71927562
114regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.71374861
115* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.71340398
116NLS-bearing protein import into nucleus (GO:0006607)2.71301836
117negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.70771471
118metaphase plate congression (GO:0051310)2.70384692
119mitotic sister chromatid cohesion (GO:0007064)2.70067116
120proteasome assembly (GO:0043248)2.69491522
121* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.68939142
122meiotic nuclear division (GO:0007126)2.67203747
123mitotic recombination (GO:0006312)2.66205318
124mitotic G1/S transition checkpoint (GO:0044819)2.66079170
125tetrahydrofolate metabolic process (GO:0046653)2.66037543
126regulation of sister chromatid segregation (GO:0033045)2.64935824
127regulation of mitotic sister chromatid separation (GO:0010965)2.64935824
128regulation of mitotic sister chromatid segregation (GO:0033047)2.64935824
129* negative regulation of ligase activity (GO:0051352)2.64170219
130* negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.64170219
131protein localization to chromosome (GO:0034502)2.64136513
132activation of Rac GTPase activity (GO:0032863)2.63509478
133NADPH regeneration (GO:0006740)2.62869095
134cell-substrate adherens junction assembly (GO:0007045)2.62196619
135focal adhesion assembly (GO:0048041)2.62196619
136mitochondrial fusion (GO:0008053)2.61903351
137* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.61163737
138adherens junction assembly (GO:0034333)2.61153166
139protein export from nucleus (GO:0006611)2.60912909
140positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.57061451
141glycolytic process (GO:0006096)2.52734651
142positive regulation of DNA-dependent DNA replication (GO:2000105)2.52699008
143actin filament depolymerization (GO:0030042)2.51686442
144ventricular cardiac muscle cell development (GO:0055015)2.49752791
145desmosome organization (GO:0002934)2.48034944
146COPII vesicle coating (GO:0048208)2.46823642
147basement membrane organization (GO:0071711)2.46028229
148deoxyribonucleotide biosynthetic process (GO:0009263)2.45063130
149protein localization to microtubule (GO:0035372)2.44584411
150positive regulation of nuclease activity (GO:0032075)2.43719870
151regulation of sister chromatid cohesion (GO:0007063)2.41847574
152activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.41278525
153regulation of translational elongation (GO:0006448)2.41005662
154endoplasmic reticulum unfolded protein response (GO:0030968)2.38492396
155negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.38083299
156nucleotide-sugar biosynthetic process (GO:0009226)2.38077017

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.09622391
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.28780716
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.88377154
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.63696941
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.23754658
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.02631332
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.68176970
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67898706
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61829804
10AR_21909140_ChIP-Seq_LNCAP_Human2.47005336
11* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44551802
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37232725
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28043639
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.25482618
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.23341326
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.21235983
17XRN2_22483619_ChIP-Seq_HELA_Human2.18506423
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.05793013
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.01956419
20ESR1_15608294_ChIP-ChIP_MCF-7_Human1.97672500
21MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95378536
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94827682
23E2F1_21310950_ChIP-Seq_MCF-7_Human1.94244012
24MYC_22102868_ChIP-Seq_BL_Human1.86224723
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.85963553
26* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85831751
27* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.85302604
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.79142523
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.77318462
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76570456
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75820980
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75080943
33CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.73663658
34DCP1A_22483619_ChIP-Seq_HELA_Human1.70836817
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69987781
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.69732089
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.66120851
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65752712
39CLOCK_20551151_ChIP-Seq_293T_Human1.64520374
40GABP_19822575_ChIP-Seq_HepG2_Human1.63914513
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63483926
42CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.59689669
43KDM5A_27292631_Chip-Seq_BREAST_Human1.54904787
44* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.52662331
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52472645
46ZNF263_19887448_ChIP-Seq_K562_Human1.50377565
47CIITA_25753668_ChIP-Seq_RAJI_Human1.50101612
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49699499
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46968372
50TFEB_21752829_ChIP-Seq_HELA_Human1.43147359
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42982793
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38733595
53CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.38353378
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38049838
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37899302
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37701145
57VDR_23849224_ChIP-Seq_CD4+_Human1.37133662
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35119918
59TTF2_22483619_ChIP-Seq_HELA_Human1.35090526
60FOXP3_21729870_ChIP-Seq_TREG_Human1.31838269
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29304475
62RACK7_27058665_Chip-Seq_MCF-7_Human1.28922016
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25841451
64CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24749264
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24137787
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22286148
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21116811
68SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.20281144
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19824556
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17859314
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17479598
72ATF3_27146783_Chip-Seq_COLON_Human1.16445669
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15404336
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14562835
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14486008
76SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14359295
77SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14359295
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14259595
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12944984
80* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10894676
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09673299
82SOX17_20123909_ChIP-Seq_XEN_Mouse1.08950181
83ELK1_19687146_ChIP-ChIP_HELA_Human1.06987918
84* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05925705
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.04419197
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04104574
87TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.03644836
88TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03524841
89TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.02130138
90TET1_21451524_ChIP-Seq_MESCs_Mouse1.01791676
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01465944
92RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98819222
93TP63_17297297_ChIP-ChIP_HaCaT_Human0.98776723
94ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98609024
95SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98553191
96CHD1_26751641_Chip-Seq_LNCaP_Human0.97952504
97ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96844181
98YY1_21170310_ChIP-Seq_MESCs_Mouse0.96211977
99SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96024628
100NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95350829
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95221427
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93715278
103CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93139584
104OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91893029
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91428734
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91265947
107ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90877006
108STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90866626
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90338192
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88521607
111NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88228392
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87779589
113* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87439242
114TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85643157
115SALL1_21062744_ChIP-ChIP_HESCs_Human0.84567501
116VDR_21846776_ChIP-Seq_THP-1_Human0.83466371
117EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.82302619
118ELK3_25401928_ChIP-Seq_HUVEC_Human0.82264352

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.73543443
2MP0004957_abnormal_blastocyst_morpholog3.44197224
3MP0010352_gastrointestinal_tract_polyps3.39227691
4MP0010094_abnormal_chromosome_stability3.35449403
5MP0003693_abnormal_embryo_hatching3.34871934
6MP0003111_abnormal_nucleus_morphology3.29797553
7MP0003077_abnormal_cell_cycle2.95629541
8MP0008877_abnormal_DNA_methylation2.89165830
9MP0003123_paternal_imprinting2.75101274
10MP0001730_embryonic_growth_arrest2.72941597
11MP0003950_abnormal_plasma_membrane2.47449981
12MP0010307_abnormal_tumor_latency2.36210793
13MP0005257_abnormal_intraocular_pressure2.30070432
14MP0000537_abnormal_urethra_morphology2.29533649
15MP0008438_abnormal_cutaneous_collagen2.29397464
16MP0005076_abnormal_cell_differentiation2.24693226
17MP0003941_abnormal_skin_development2.18031714
18MP0008007_abnormal_cellular_replicative2.16407515
19MP0008057_abnormal_DNA_replication2.11623123
20MP0000350_abnormal_cell_proliferation2.03841879
21MP0008932_abnormal_embryonic_tissue2.00608323
22MP0003566_abnormal_cell_adhesion1.94081463
23MP0004233_abnormal_muscle_weight1.92634478
24MP0008058_abnormal_DNA_repair1.91794476
25MP0004197_abnormal_fetal_growth/weight/1.88486612
26MP0008260_abnormal_autophagy1.81657470
27MP0009053_abnormal_anal_canal1.80632212
28MP0005501_abnormal_skin_physiology1.80314380
29MP0001672_abnormal_embryogenesis/_devel1.79149648
30MP0005380_embryogenesis_phenotype1.79149648
31MP0002796_impaired_skin_barrier1.79125180
32MP0001697_abnormal_embryo_size1.76945799
33MP0003806_abnormal_nucleotide_metabolis1.74991532
34MP0005451_abnormal_body_composition1.72725179
35MP0003984_embryonic_growth_retardation1.71925606
36MP0002088_abnormal_embryonic_growth/wei1.69713368
37MP0002080_prenatal_lethality1.68108558
38MP0002084_abnormal_developmental_patter1.66293236
39MP0002060_abnormal_skin_morphology1.62344774
40MP0006054_spinal_hemorrhage1.61543999
41MP0010030_abnormal_orbit_morphology1.58658440
42MP0002085_abnormal_embryonic_tissue1.55920329
43MP0003221_abnormal_cardiomyocyte_apopto1.55169813
44MP0000762_abnormal_tongue_morphology1.52758207
45MP0005623_abnormal_meninges_morphology1.52404724
46MP0002086_abnormal_extraembryonic_tissu1.51788165
47MP0000749_muscle_degeneration1.47472878
48MP0009697_abnormal_copulation1.47021965
49MP0004084_abnormal_cardiac_muscle1.46694254
50MP0010234_abnormal_vibrissa_follicle1.42813409
51MP0000579_abnormal_nail_morphology1.42060353
52MP0002269_muscular_atrophy1.41257691
53MP0003786_premature_aging1.38458203
54MP0005023_abnormal_wound_healing1.34984621
55MP0001849_ear_inflammation1.34561919
56MP0003121_genomic_imprinting1.31746133
57MP0002210_abnormal_sex_determination1.31519177
58MP0000733_abnormal_muscle_development1.31047432
59MP0003453_abnormal_keratinocyte_physiol1.28483962
60MP0002877_abnormal_melanocyte_morpholog1.26803404
61MP0000467_abnormal_esophagus_morphology1.25332263
62MP0001299_abnormal_eye_distance/1.24854527
63MP0005408_hypopigmentation1.22513117
64MP0000358_abnormal_cell_content/1.22066452
65MP0005275_abnormal_skin_tensile1.22041912
66MP0009672_abnormal_birth_weight1.21362333
67MP0003567_abnormal_fetal_cardiomyocyte1.19778802
68MP0003115_abnormal_respiratory_system1.18085988
69MP0002653_abnormal_ependyma_morphology1.17717608
70MP0001145_abnormal_male_reproductive1.14563705
71MP0001216_abnormal_epidermal_layer1.13245652
72MP0000003_abnormal_adipose_tissue1.13098887
73MP0000750_abnormal_muscle_regeneration1.12504638
74MP0003890_abnormal_embryonic-extraembry1.11402889
75MP0001929_abnormal_gametogenesis1.11339337
76MP0001348_abnormal_lacrimal_gland1.10547739
77MP0001915_intracranial_hemorrhage1.10303796
78MP0003119_abnormal_digestive_system1.10141764
79MP0010368_abnormal_lymphatic_system1.08989622
80MP0004858_abnormal_nervous_system1.08078764
81MP0000313_abnormal_cell_death1.06629498
82MP0005197_abnormal_uvea_morphology1.06112074
83MP0003191_abnormal_cellular_cholesterol1.05612230
84MP0003315_abnormal_perineum_morphology1.03917870
85MP0004087_abnormal_muscle_fiber1.01078549
86MP0003385_abnormal_body_wall1.01072754
87MP0009840_abnormal_foam_cell1.00295334
88MP0001661_extended_life_span0.99489842
89MP0000751_myopathy0.96981374
90MP0000534_abnormal_ureter_morphology0.96930074
91MP0000428_abnormal_craniofacial_morphol0.95475110
92MP0004808_abnormal_hematopoietic_stem0.92443214
93MP0000627_abnormal_mammary_gland0.91743219
94MP0002019_abnormal_tumor_incidence0.91508860
95MP0005384_cellular_phenotype0.90778835
96MP0005058_abnormal_lysosome_morphology0.89421162
97MP0005330_cardiomyopathy0.89373716
98MP0000653_abnormal_sex_gland0.89179872
99MP0005621_abnormal_cell_physiology0.88739607
100MP0010771_integument_phenotype0.87574092
101MP0003283_abnormal_digestive_organ0.85662775
102MP0000013_abnormal_adipose_tissue0.85350339
103MP0003091_abnormal_cell_migration0.84310692
104MP0000858_altered_metastatic_potential0.83637015
105MP0002111_abnormal_tail_morphology0.83236574
106MP0003942_abnormal_urinary_system0.82054624
107MP0002896_abnormal_bone_mineralization0.81327383
108MP0004185_abnormal_adipocyte_glucose0.80422111
109MP0009780_abnormal_chondrocyte_physiolo0.80353137
110MP0010630_abnormal_cardiac_muscle0.79879218
111MP0000747_muscle_weakness0.79838105
112MP0000377_abnormal_hair_follicle0.79817152
113MP0000678_abnormal_parathyroid_gland0.79769309
114MP0003755_abnormal_palate_morphology0.78549759
115MP0002177_abnormal_outer_ear0.78361532
116MP0003698_abnormal_male_reproductive0.77459066
117MP0001881_abnormal_mammary_gland0.77336921
118MP0004272_abnormal_basement_membrane0.77143652
119MP0001727_abnormal_embryo_implantation0.76069162
120MP0002697_abnormal_eye_size0.75821929
121MP0005187_abnormal_penis_morphology0.74487000
122MP0000759_abnormal_skeletal_muscle0.71775749
123MP0004264_abnormal_extraembryonic_tissu0.70917501
124MP0009703_decreased_birth_body0.69731000
125MP0002160_abnormal_reproductive_system0.69343966
126MP0000266_abnormal_heart_morphology0.68802959
127MP0002089_abnormal_postnatal_growth/wei0.68138743
128MP0001243_abnormal_dermal_layer0.66900013
129MP0002161_abnormal_fertility/fecundity0.64941628
130MP0002092_abnormal_eye_morphology0.64798017
131MP0003718_maternal_effect0.63222732
132MP0002396_abnormal_hematopoietic_system0.62958471
133MP0000598_abnormal_liver_morphology0.62745409
134MP0003279_aneurysm0.62684061
135MP0002925_abnormal_cardiovascular_devel0.62392971
136MP0001293_anophthalmia0.62211644
137MP0002234_abnormal_pharynx_morphology0.61069633
138MP0005266_abnormal_metabolism0.60770596
139MP0009278_abnormal_bone_marrow0.59749068
140MP0008770_decreased_survivor_rate0.59740438

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.02101448
2Abnormality of the lower motor neuron (HP:0002366)3.75057467
3Selective tooth agenesis (HP:0001592)3.62841584
4Abnormality of the anterior horn cell (HP:0006802)3.62482738
5Degeneration of anterior horn cells (HP:0002398)3.62482738
6Hand muscle atrophy (HP:0009130)3.40878311
7Astrocytoma (HP:0009592)3.21164380
8Abnormality of the astrocytes (HP:0100707)3.21164380
9Abnormality of the calcaneus (HP:0008364)3.20887280
10Shoulder girdle muscle weakness (HP:0003547)3.16625158
11Protrusio acetabuli (HP:0003179)3.12800525
12Short nail (HP:0001799)3.11189587
13Spinal rigidity (HP:0003306)3.09515272
14Distal lower limb amyotrophy (HP:0008944)3.08228817
15Ankle contracture (HP:0006466)3.05598574
16Distal upper limb amyotrophy (HP:0007149)3.01623384
17Upper limb amyotrophy (HP:0009129)3.01623384
18Pelvic girdle muscle weakness (HP:0003749)3.01507157
19Achilles tendon contracture (HP:0001771)2.83305629
20Vertebral compression fractures (HP:0002953)2.82455851
21Cutaneous melanoma (HP:0012056)2.78124591
22Metaphyseal cupping (HP:0003021)2.75378878
23Abnormal gallbladder physiology (HP:0012438)2.70875391
24Cholecystitis (HP:0001082)2.70875391
25Increased connective tissue (HP:0009025)2.68475576
26Difficulty climbing stairs (HP:0003551)2.66117817
27Insomnia (HP:0100785)2.64536049
28Atrophic scars (HP:0001075)2.64343824
29Distal lower limb muscle weakness (HP:0009053)2.63638540
30Missing ribs (HP:0000921)2.63060822
31Deviation of the thumb (HP:0009603)2.55801066
32Abnormality of the hip-girdle musculature (HP:0001445)2.51263818
33Abnormality of the musculature of the pelvis (HP:0001469)2.51263818
34Premature rupture of membranes (HP:0001788)2.50934095
35Atrophy/Degeneration involving motor neurons (HP:0007373)2.50771544
36Colon cancer (HP:0003003)2.49736110
37Angiofibromas (HP:0010615)2.49171357
38Adenoma sebaceum (HP:0009720)2.49171357
39Osteolytic defects of the hand bones (HP:0009699)2.47952578
40Osteolytic defects of the phalanges of the hand (HP:0009771)2.47952578
41Wrist flexion contracture (HP:0001239)2.44934951
42Proximal placement of thumb (HP:0009623)2.44176005
43Glioma (HP:0009733)2.41659567
44Abnormality of the Achilles tendon (HP:0005109)2.40099937
45Lower limb amyotrophy (HP:0007210)2.40065541
46Termporal pattern (HP:0011008)2.38713616
47Insidious onset (HP:0003587)2.38713616
48Abnormality of the distal phalanges of the toes (HP:0010182)2.34739937
49Short 4th metacarpal (HP:0010044)2.33243071
50Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.33243071
51Ulnar bowing (HP:0003031)2.32077159
52Exercise-induced muscle cramps (HP:0003710)2.31437626
53Cerebral aneurysm (HP:0004944)2.30912166
54Fragile skin (HP:0001030)2.29094410
55Abnormality of the umbilical cord (HP:0010881)2.28805290
5611 pairs of ribs (HP:0000878)2.28126416
57Entropion (HP:0000621)2.27849871
58Ankyloglossia (HP:0010296)2.27611572
59Back pain (HP:0003418)2.27440890
60Medulloblastoma (HP:0002885)2.25710126
61Upper limb muscle weakness (HP:0003484)2.25599774
62Bowel diverticulosis (HP:0005222)2.24790515
63Multiple enchondromatosis (HP:0005701)2.23550157
64Elbow flexion contracture (HP:0002987)2.22998005
65Abnormality of oral frenula (HP:0000190)2.22966897
66Spastic diplegia (HP:0001264)2.20649913
67Hyperacusis (HP:0010780)2.19530634
68Increased nuchal translucency (HP:0010880)2.19092376
69Upper motor neuron abnormality (HP:0002127)2.18981248
70Ulnar deviation of the wrist (HP:0003049)2.18811421
71Limb-girdle muscle weakness (HP:0003325)2.16638856
72Progressive muscle weakness (HP:0003323)2.14722226
73Cortical dysplasia (HP:0002539)2.12438295
74Centrally nucleated skeletal muscle fibers (HP:0003687)2.11826336
75Increased density of long bones (HP:0006392)2.11154188
76Long palpebral fissure (HP:0000637)2.10920735
77Cervical subluxation (HP:0003308)2.10496306
78Biliary tract neoplasm (HP:0100574)2.10213989
79Hypokinesia (HP:0002375)2.09924660
80Ragged-red muscle fibers (HP:0003200)2.09718906
81Abnormality of the motor neurons (HP:0002450)2.09604935
82Abnormal neuron morphology (HP:0012757)2.09604935
83Agnosia (HP:0010524)2.08284140
84Shallow orbits (HP:0000586)2.08080890
85Reduced subcutaneous adipose tissue (HP:0003758)2.05665870
86Calcaneovalgus deformity (HP:0001848)2.04013206
87Generalized amyotrophy (HP:0003700)2.03824392
88Limb-girdle muscle atrophy (HP:0003797)2.03533199
89Renal duplication (HP:0000075)2.03207081
90Bladder diverticulum (HP:0000015)2.02232289
91Natal tooth (HP:0000695)2.01676491
92High pitched voice (HP:0001620)2.00755710
93Trismus (HP:0000211)2.00085848
94Rough bone trabeculation (HP:0100670)1.99524352
95Abnormality of the 4th metacarpal (HP:0010012)1.98837535
96Mildly elevated creatine phosphokinase (HP:0008180)1.97817308
97Microvesicular hepatic steatosis (HP:0001414)1.97716668
98Neoplasm of the pancreas (HP:0002894)1.95555290
99Ovarian neoplasm (HP:0100615)1.95490551
100Rhabdomyolysis (HP:0003201)1.95064779
101Spinal muscular atrophy (HP:0007269)1.94813196
102Resting tremor (HP:0002322)1.94219581
103Microglossia (HP:0000171)1.93351710
104Type 1 muscle fiber predominance (HP:0003803)1.92400206
105Broad face (HP:0000283)1.91333548
106Abnormality of glycolysis (HP:0004366)1.90632158
107Increased serum pyruvate (HP:0003542)1.90632158
108Onycholysis (HP:0001806)1.89934200
109Wormian bones (HP:0002645)1.88057865
110Abnormalities of placenta or umbilical cord (HP:0001194)1.87537991
111Intestinal polyposis (HP:0200008)1.87500180
112Intestinal polyp (HP:0005266)1.87473953
113Fibroma (HP:0010614)1.86368140
114Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86149371
115Deformed tarsal bones (HP:0008119)1.85109651
116Slender long bone (HP:0003100)1.84931838
117Neoplasm of the rectum (HP:0100743)1.84663455
118Amyotrophic lateral sclerosis (HP:0007354)1.84373490
119Broad distal phalanx of finger (HP:0009836)1.82997485
120Myopathic facies (HP:0002058)1.82986284
121Fragile nails (HP:0001808)1.82395731
122Abnormality of dentin (HP:0010299)1.81992767
123Nail dystrophy (HP:0008404)1.81599057
124Abnormality of the labia minora (HP:0012880)1.81377022
125Carpal bone hypoplasia (HP:0001498)1.77804425
126Fasciculations (HP:0002380)1.77402576
127Rimmed vacuoles (HP:0003805)1.76171694
128Gonadotropin excess (HP:0000837)1.75627040
129Overriding aorta (HP:0002623)1.75285690
130Renovascular hypertension (HP:0100817)1.74808578
131Personality changes (HP:0000751)1.74050416
132Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73052104
133Fibrous tissue neoplasm (HP:0012316)1.73038734
134Gastrointestinal carcinoma (HP:0002672)1.72855881
135Malignant gastrointestinal tract tumors (HP:0006749)1.72855881
136Muscle fibrillation (HP:0010546)1.72451239
137Hypopigmentation of the fundus (HP:0007894)1.72247308
138Dilatation of the ascending aorta (HP:0005111)1.72032354
139Poikiloderma (HP:0001029)1.70875432
140Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.67471181
141Subacute progressive viral hepatitis (HP:0006572)1.67058824
142Hypoplastic pelvis (HP:0008839)1.66377464
143Abnormality of skeletal muscle fiber size (HP:0012084)1.66209964
144Freckling (HP:0001480)1.66074783
145Posterior subcapsular cataract (HP:0007787)1.65628278
146Sparse eyelashes (HP:0000653)1.64518080
147Spinal cord compression (HP:0002176)1.64463129
148Cafe-au-lait spot (HP:0000957)1.64401094
149Scapular winging (HP:0003691)1.64064950
150Lymphangioma (HP:0100764)1.62516375
151Abnormality of the fetal cardiovascular system (HP:0010948)1.62339843
152Abnormal umbilical cord blood vessels (HP:0011403)1.62339843
153Single umbilical artery (HP:0001195)1.62339843
154Long toe (HP:0010511)1.62247670
155Aplasia/hypoplasia of the humerus (HP:0006507)1.62187355
156Nemaline bodies (HP:0003798)1.60982453
157Myoglobinuria (HP:0002913)1.60946221
158Glossoptosis (HP:0000162)1.60568258
159Secondary amenorrhea (HP:0000869)1.59164814
160Pterygium (HP:0001059)1.58890701
161Abnormality of pain sensation (HP:0010832)1.57601275
162Impaired pain sensation (HP:0007328)1.57601275
163Arterial tortuosity (HP:0005116)1.57253125
164Chromosomal breakage induced by crosslinking agents (HP:0003221)1.55417241
165Unilateral renal agenesis (HP:0000122)1.55344319
166Breech presentation (HP:0001623)1.54640776
167Progressive hearing impairment (HP:0001730)1.53290326

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.09390674
2CDC73.34133576
3TRIB33.18391134
4PKN22.86146046
5BUB12.81822507
6TSSK62.66091592
7WEE12.65934244
8EEF2K2.64247142
9PDK32.61774259
10PDK42.61774259
11MST1R2.53868461
12SMG12.47193791
13TESK12.43452421
14TTN2.42046481
15PBK2.37454748
16NEK22.34195368
17SCYL22.31955818
18NME22.31163987
19IRAK32.30552666
20PASK2.13147872
21CDK122.09976513
22ARAF1.98032504
23ACVR1B1.91492754
24ERBB41.81077742
25EPHA21.80125380
26PAK41.75381092
27TTK1.68601348
28EIF2AK11.66920976
29VRK21.63031502
30NTRK11.58422932
31PDK21.51927834
32TESK21.51812975
33RPS6KB21.47532834
34PDGFRA1.37760016
35PLK11.34912708
36LATS21.30952217
37MAP3K101.30710988
38LIMK11.30657874
39PLK31.30495854
40TGFBR11.25343063
41MAP3K91.24099781
42ATR1.20755945
43MAP3K81.19712527
44BRSK11.13910038
45ALK1.10998969
46CDK81.10363751
47MOS1.09925522
48MTOR1.07949587
49CHEK11.06088722
50RPS6KA41.00482470
51CDK41.00443904
52AURKB1.00351797
53LRRK21.00087160
54SIK10.98886856
55BRSK20.98839182
56EPHB10.96163353
57BRAF0.95964977
58PTK60.94829846
59TAOK20.93600458
60PAK20.90748905
61AURKA0.88033907
62STK38L0.87771213
63ICK0.87170983
64MAPKAPK30.86402418
65FGFR10.85482995
66CDK70.84305518
67SRPK10.84065719
68PRKD30.80279282
69MAP3K120.79727581
70KSR10.79563473
71STK100.78871314
72PIM20.78579331
73PRPF4B0.76376235
74PAK10.75518747
75FLT30.74893207
76RIPK10.74738666
77BMX0.70796260
78CLK10.68982452
79EPHB20.68643997
80STK30.67018977
81CDK20.66486285
82DDR20.66384095
83ATM0.63608175
84LATS10.62908145
85KSR20.61366176
86ABL20.61317010
87ILK0.61101914
88CHEK20.61034209
89CDK60.60516747
90DAPK10.60358891
91CDK90.57351501
92TAF10.56183238
93MAP2K30.54743224
94MET0.54734338
95MYLK0.54004970
96PLK40.53880127
97LMTK20.53809408
98CDK10.53798030
99CDK11A0.53502805
100FER0.53366399
101ERBB30.51865356
102CSNK1G30.51761753
103NEK90.50610547
104PTK20.50567389
105CCNB10.50323281
106CSNK1A1L0.49479369
107EIF2AK30.49092637
108STK40.48143213
109SIK30.47786371
110MAP2K10.47109443
111ERN10.46551071
112ROCK20.44590303
113BCKDK0.44087144
114MAPK110.43427911
115STK380.42087874
116RAF10.40347475
117CSNK1E0.40008960
118BCR0.39897065
119KDR0.38828118
120CSNK2A20.38670277
121MELK0.38393516
122MKNK10.37413245
123TYRO30.36683202
124PRKDC0.35898067
125CDK180.35061752
126PAK60.33214126
127CDK150.33172038
128PAK30.32859214
129MAP3K30.32580942
130BRD40.32570117
131CDK140.32401555
132PRKCI0.32010258
133FGFR40.29634124
134RET0.29442759
135AKT20.29091066

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.77840047
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.28937796
3RNA transport_Homo sapiens_hsa030133.20751815
4Mismatch repair_Homo sapiens_hsa034303.10476856
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.04857973
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98371849
7One carbon pool by folate_Homo sapiens_hsa006702.93227211
8* Proteasome_Homo sapiens_hsa030502.82736619
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.61078397
10Spliceosome_Homo sapiens_hsa030402.59078637
11Cell cycle_Homo sapiens_hsa041102.53699822
12Biosynthesis of amino acids_Homo sapiens_hsa012302.15344270
13Nucleotide excision repair_Homo sapiens_hsa034202.04861012
14Base excision repair_Homo sapiens_hsa034102.04276093
15Carbon metabolism_Homo sapiens_hsa012001.96310996
16Selenocompound metabolism_Homo sapiens_hsa004501.93843597
17mRNA surveillance pathway_Homo sapiens_hsa030151.79455308
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.75931445
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62414671
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.45165181
21Homologous recombination_Homo sapiens_hsa034401.44888132
22Pyruvate metabolism_Homo sapiens_hsa006201.42458682
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.42072720
24Oocyte meiosis_Homo sapiens_hsa041141.39465296
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.35277149
26p53 signaling pathway_Homo sapiens_hsa041151.35245635
27Pentose phosphate pathway_Homo sapiens_hsa000301.32814398
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.32790452
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.28859640
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28076668
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28002078
32Pyrimidine metabolism_Homo sapiens_hsa002401.25524995
33Vibrio cholerae infection_Homo sapiens_hsa051101.24682084
34RNA polymerase_Homo sapiens_hsa030201.24309739
35Viral carcinogenesis_Homo sapiens_hsa052031.24091928
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23640267
37Fatty acid elongation_Homo sapiens_hsa000621.21520004
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18800528
39Sulfur relay system_Homo sapiens_hsa041221.12447568
40RNA degradation_Homo sapiens_hsa030181.08423008
41Antigen processing and presentation_Homo sapiens_hsa046121.07344628
42* Epstein-Barr virus infection_Homo sapiens_hsa051691.07150107
43Non-homologous end-joining_Homo sapiens_hsa034501.06055098
44Folate biosynthesis_Homo sapiens_hsa007900.97939728
45mTOR signaling pathway_Homo sapiens_hsa041500.94923602
46Fanconi anemia pathway_Homo sapiens_hsa034600.94171768
47Steroid biosynthesis_Homo sapiens_hsa001000.93773886
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93150838
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93042395
50Legionellosis_Homo sapiens_hsa051340.93013011
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91557076
52Hippo signaling pathway_Homo sapiens_hsa043900.91186365
53Systemic lupus erythematosus_Homo sapiens_hsa053220.90741895
54Adherens junction_Homo sapiens_hsa045200.85567310
55Bladder cancer_Homo sapiens_hsa052190.84200565
56Thyroid cancer_Homo sapiens_hsa052160.83503018
57Small cell lung cancer_Homo sapiens_hsa052220.83197034
58MicroRNAs in cancer_Homo sapiens_hsa052060.82151135
59Fructose and mannose metabolism_Homo sapiens_hsa000510.80845955
60HTLV-I infection_Homo sapiens_hsa051660.79947076
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.78925115
62Basal transcription factors_Homo sapiens_hsa030220.76851150
63Chronic myeloid leukemia_Homo sapiens_hsa052200.76361417
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75354559
65HIF-1 signaling pathway_Homo sapiens_hsa040660.73040339
66Proteoglycans in cancer_Homo sapiens_hsa052050.71641913
67Tight junction_Homo sapiens_hsa045300.68588594
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68347353
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.68003008
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67644389
71Viral myocarditis_Homo sapiens_hsa054160.66825308
72Fatty acid degradation_Homo sapiens_hsa000710.63435968
73N-Glycan biosynthesis_Homo sapiens_hsa005100.62447101
74Colorectal cancer_Homo sapiens_hsa052100.60581956
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60118687
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59832922
77Arginine and proline metabolism_Homo sapiens_hsa003300.59795745
78Focal adhesion_Homo sapiens_hsa045100.59505610
79Fatty acid metabolism_Homo sapiens_hsa012120.59424654
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59391341
81Renal cell carcinoma_Homo sapiens_hsa052110.58801376
82Dilated cardiomyopathy_Homo sapiens_hsa054140.54386232
83Shigellosis_Homo sapiens_hsa051310.53872258
84AMPK signaling pathway_Homo sapiens_hsa041520.52959371
85Prostate cancer_Homo sapiens_hsa052150.52703822
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52642437
87Endometrial cancer_Homo sapiens_hsa052130.52539865
88Propanoate metabolism_Homo sapiens_hsa006400.51661253
89Galactose metabolism_Homo sapiens_hsa000520.50730982
90Insulin signaling pathway_Homo sapiens_hsa049100.50689208
91Glucagon signaling pathway_Homo sapiens_hsa049220.49904669
92Melanoma_Homo sapiens_hsa052180.48873079
93TGF-beta signaling pathway_Homo sapiens_hsa043500.47577749
94Lysine degradation_Homo sapiens_hsa003100.47462237
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.46586399
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46484782
97ErbB signaling pathway_Homo sapiens_hsa040120.46019120
98Salmonella infection_Homo sapiens_hsa051320.45519832
99Apoptosis_Homo sapiens_hsa042100.45485173
100Other glycan degradation_Homo sapiens_hsa005110.45358953
101Purine metabolism_Homo sapiens_hsa002300.44933613
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44317519
103Endocytosis_Homo sapiens_hsa041440.42026390
104Pathways in cancer_Homo sapiens_hsa052000.41531295
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41198726
106Sulfur metabolism_Homo sapiens_hsa009200.38287604
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38209525
108Non-small cell lung cancer_Homo sapiens_hsa052230.33657600
109Insulin resistance_Homo sapiens_hsa049310.33000470
110ECM-receptor interaction_Homo sapiens_hsa045120.30360118
111Basal cell carcinoma_Homo sapiens_hsa052170.30292131
112Pancreatic cancer_Homo sapiens_hsa052120.27988123
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27837292
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.27545560
115Glutathione metabolism_Homo sapiens_hsa004800.27528979
116Glioma_Homo sapiens_hsa052140.26633281
117Alcoholism_Homo sapiens_hsa050340.25567764
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25408363
119Herpes simplex infection_Homo sapiens_hsa051680.24596842
120Vitamin B6 metabolism_Homo sapiens_hsa007500.23185152
121Amoebiasis_Homo sapiens_hsa051460.22730952
122Fat digestion and absorption_Homo sapiens_hsa049750.22283050
123Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20172047
124Arginine biosynthesis_Homo sapiens_hsa002200.20013027
125VEGF signaling pathway_Homo sapiens_hsa043700.19680071
126Prion diseases_Homo sapiens_hsa050200.19587181

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