PSMD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)5.08192002
2regulation of translational termination (GO:0006449)4.55385845
3DNA unwinding involved in DNA replication (GO:0006268)4.45172240
4formation of translation preinitiation complex (GO:0001731)4.33667743
5regulation of mammary gland epithelial cell proliferation (GO:0033599)4.26961223
6regulation of translational fidelity (GO:0006450)4.23837722
7protein retention in ER lumen (GO:0006621)4.18118676
8folic acid metabolic process (GO:0046655)4.17997095
9nuclear pore complex assembly (GO:0051292)4.17917312
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.14852143
11retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.09008838
12nucleobase biosynthetic process (GO:0046112)4.01508321
13protein localization to kinetochore (GO:0034501)3.90274676
14mitotic nuclear envelope disassembly (GO:0007077)3.75755188
15glycine metabolic process (GO:0006544)3.75295230
16IMP biosynthetic process (GO:0006188)3.73796539
17ribosome assembly (GO:0042255)3.65946224
18DNA strand elongation involved in DNA replication (GO:0006271)3.64199740
19protein localization to endosome (GO:0036010)3.62725102
20proline metabolic process (GO:0006560)3.62233306
21DNA replication initiation (GO:0006270)3.56381334
22desmosome organization (GO:0002934)3.56114371
23peptidyl-arginine omega-N-methylation (GO:0035247)3.55569940
24nuclear envelope disassembly (GO:0051081)3.54067019
25membrane disassembly (GO:0030397)3.54067019
26adherens junction assembly (GO:0034333)3.52843779
27purine nucleobase biosynthetic process (GO:0009113)3.47519926
28mitotic G1 DNA damage checkpoint (GO:0031571)3.47340875
29cell-substrate adherens junction assembly (GO:0007045)3.47239847
30focal adhesion assembly (GO:0048041)3.47239847
31maternal placenta development (GO:0001893)3.44924442
32cellular protein complex localization (GO:0034629)3.43111378
33DNA strand elongation (GO:0022616)3.40909457
34negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.35102262
35pentose-phosphate shunt (GO:0006098)3.33382223
36IMP metabolic process (GO:0046040)3.31937399
37heterochromatin organization (GO:0070828)3.29355137
38DNA replication-dependent nucleosome organization (GO:0034723)3.29194988
39DNA replication-dependent nucleosome assembly (GO:0006335)3.29194988
40ribosome biogenesis (GO:0042254)3.27065164
41cytoskeletal anchoring at plasma membrane (GO:0007016)3.23967163
42activation of Rac GTPase activity (GO:0032863)3.22637197
43DNA deamination (GO:0045006)3.18998251
44chromosome condensation (GO:0030261)3.18383769
45regulation of gene silencing by RNA (GO:0060966)3.17310451
46regulation of posttranscriptional gene silencing (GO:0060147)3.17310451
47regulation of gene silencing by miRNA (GO:0060964)3.17310451
48serine family amino acid biosynthetic process (GO:0009070)3.14778724
49negative regulation of cell size (GO:0045792)3.13868712
50pteridine-containing compound biosynthetic process (GO:0042559)3.13756503
51activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.13463489
52L-serine metabolic process (GO:0006563)3.12062978
53protein-DNA complex disassembly (GO:0032986)3.10694704
54nucleosome disassembly (GO:0006337)3.10694704
55tetrahydrofolate metabolic process (GO:0046653)3.10460716
56protein localization to chromosome, centromeric region (GO:0071459)3.10151172
57regulation of early endosome to late endosome transport (GO:2000641)3.09180267
58positive regulation of nuclease activity (GO:0032075)3.08694518
59planar cell polarity pathway involved in neural tube closure (GO:0090179)3.07217740
60pore complex assembly (GO:0046931)3.07164844
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.07048077
62nuclear envelope organization (GO:0006998)3.06294181
63cell-substrate junction assembly (GO:0007044)3.05913482
64glucose 6-phosphate metabolic process (GO:0051156)3.05794991
65histone arginine methylation (GO:0034969)3.04954624
66mitotic G1/S transition checkpoint (GO:0044819)3.02847985
67regulation of RNA export from nucleus (GO:0046831)3.01779285
68pre-miRNA processing (GO:0031054)3.00076092
69protein maturation by protein folding (GO:0022417)2.99435634
70regulation of nucleobase-containing compound transport (GO:0032239)2.98486979
71maturation of SSU-rRNA (GO:0030490)2.98325181
723-UTR-mediated mRNA stabilization (GO:0070935)2.97865598
73regulation of hippo signaling (GO:0035330)2.96966429
74folic acid-containing compound metabolic process (GO:0006760)2.96770312
75peptidyl-arginine N-methylation (GO:0035246)2.95060453
76peptidyl-arginine methylation (GO:0018216)2.95060453
77RNA stabilization (GO:0043489)2.94258467
78mRNA stabilization (GO:0048255)2.94258467
79telomere maintenance via semi-conservative replication (GO:0032201)2.93619912
80protein export from nucleus (GO:0006611)2.93234186
81negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.92339926
82glucose catabolic process (GO:0006007)2.92023734
83nuclear pore organization (GO:0006999)2.91005577
84translational initiation (GO:0006413)2.90357922
85cellular response to epidermal growth factor stimulus (GO:0071364)2.89934078
86DNA duplex unwinding (GO:0032508)2.89838279
87regulation of glucose import in response to insulin stimulus (GO:2001273)2.89440283
88NADPH regeneration (GO:0006740)2.87905373
89mitotic metaphase plate congression (GO:0007080)2.86832934
90DNA geometric change (GO:0032392)2.86524832
91mitotic sister chromatid segregation (GO:0000070)2.85734031
92positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.84870991
93regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.83840174
94basement membrane organization (GO:0071711)2.83601073
95Golgi transport vesicle coating (GO:0048200)2.83537210
96COPI coating of Golgi vesicle (GO:0048205)2.83537210
97negative regulation of RNA splicing (GO:0033119)2.83155950
98vesicle coating (GO:0006901)2.82191615
99endoplasmic reticulum unfolded protein response (GO:0030968)2.82144804
100regulation of translational elongation (GO:0006448)2.81875657
101paraxial mesoderm development (GO:0048339)2.81147716
102regulation of spindle organization (GO:0090224)2.80377920
103intracellular estrogen receptor signaling pathway (GO:0030520)2.80361305
104regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.80153764
105lysine catabolic process (GO:0006554)2.80010960
106lysine metabolic process (GO:0006553)2.80010960
107NADH metabolic process (GO:0006734)2.79915772
108regulation of nuclease activity (GO:0032069)2.79217959
109translational elongation (GO:0006414)2.76722672
110serine family amino acid metabolic process (GO:0009069)2.75957551
111regulation of NFAT protein import into nucleus (GO:0051532)2.75261643
112mitochondrial DNA metabolic process (GO:0032042)2.74209645
113DNA replication checkpoint (GO:0000076)2.74159974
114ER-nucleus signaling pathway (GO:0006984)2.74006561
115nucleobase-containing small molecule interconversion (GO:0015949)2.72587789
116negative regulation of mRNA processing (GO:0050686)2.72221457
117hemidesmosome assembly (GO:0031581)2.72023662
118epithelial cell-cell adhesion (GO:0090136)2.69818918
119one-carbon metabolic process (GO:0006730)2.68673189
120protein complex localization (GO:0031503)2.68369562
121spliceosomal tri-snRNP complex assembly (GO:0000244)2.67877896
122nucleoside salvage (GO:0043174)2.67374646
123viral transcription (GO:0019083)2.66063372
124chaperone-mediated protein complex assembly (GO:0051131)2.65795910
125positive regulation of SMAD protein import into nucleus (GO:0060391)2.65482667
126pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.65250594
127apoptotic process involved in morphogenesis (GO:0060561)2.64979189
128regulation of cholesterol homeostasis (GO:2000188)2.64470359
129translational termination (GO:0006415)2.64316894
130mitotic nuclear envelope reassembly (GO:0007084)2.63727305
131nuclear envelope reassembly (GO:0031468)2.63727305
132negative regulation of mRNA metabolic process (GO:1903312)2.63260965
1334-hydroxyproline metabolic process (GO:0019471)2.61995499
134UMP metabolic process (GO:0046049)2.61871610
135pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.61871610
136UMP biosynthetic process (GO:0006222)2.61871610
137pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.61871610
138glycolytic process (GO:0006096)2.61551400
139ribonucleoprotein complex biogenesis (GO:0022613)2.61441127
140positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.60017567
141proline biosynthetic process (GO:0006561)2.59588203
142mitotic chromosome condensation (GO:0007076)2.59237122
143DNA packaging (GO:0006323)2.58119451
144cellular response to unfolded protein (GO:0034620)2.57726385
145sister chromatid segregation (GO:0000819)2.57028232
146tricarboxylic acid metabolic process (GO:0072350)2.56809226
147pinocytosis (GO:0006907)2.56776396
148G1 DNA damage checkpoint (GO:0044783)2.55587987
149peptidyl-lysine dimethylation (GO:0018027)2.55442829
150dosage compensation (GO:0007549)2.55043793
151positive regulation of chromosome segregation (GO:0051984)2.54943920
152peptidyl-proline hydroxylation (GO:0019511)2.54940895
153negative regulation of erythrocyte differentiation (GO:0045647)2.54883287
154mitochondrial fusion (GO:0008053)2.53678923
155negative regulation of histone methylation (GO:0031061)2.51799789
156barbed-end actin filament capping (GO:0051016)2.51284352
157nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.50717420
158semaphorin-plexin signaling pathway (GO:0071526)2.50040433
159tRNA aminoacylation for protein translation (GO:0006418)2.49405953
160glucocorticoid receptor signaling pathway (GO:0042921)2.48610286
161positive regulation of keratinocyte differentiation (GO:0045618)2.48128914
1622-oxoglutarate metabolic process (GO:0006103)2.48005482
163trophectodermal cell differentiation (GO:0001829)2.47982214
164branching involved in mammary gland duct morphogenesis (GO:0060444)2.47818923
165COPII vesicle coating (GO:0048208)2.46880530
166nucleotide salvage (GO:0043173)2.46864104
167glutamine family amino acid biosynthetic process (GO:0009084)2.46830850
168regulation of histone H3-K27 methylation (GO:0061085)2.46400980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.34719077
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.84551215
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.38485176
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.24481416
5MYC_22102868_ChIP-Seq_BL_Human2.59161252
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52992965
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22366233
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11028930
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.10683934
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.09279745
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.06733029
12ZNF263_19887448_ChIP-Seq_K562_Human2.00028573
13XRN2_22483619_ChIP-Seq_HELA_Human1.99435330
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.95164814
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90870196
16E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89720290
17* ETS1_20019798_ChIP-Seq_JURKAT_Human1.89463030
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85421044
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.84910406
20* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.79007893
21AR_21909140_ChIP-Seq_LNCAP_Human1.76256321
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75912434
23VDR_21846776_ChIP-Seq_THP-1_Human1.70088897
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66426705
25* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64178683
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63179768
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.60832484
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58844520
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.58233428
30* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55535449
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51452415
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51092430
33KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50585327
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.50584892
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50191895
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.49370277
37* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48960348
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46798595
39GABP_19822575_ChIP-Seq_HepG2_Human1.46577679
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44582076
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42827617
42ATF3_27146783_Chip-Seq_COLON_Human1.41109590
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39808220
44NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39413145
45PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39323436
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.39230150
47* CIITA_25753668_ChIP-Seq_RAJI_Human1.39074671
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37416959
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37246856
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35743753
51KDM5A_27292631_Chip-Seq_BREAST_Human1.35320869
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.33828274
53DCP1A_22483619_ChIP-Seq_HELA_Human1.33736133
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32753797
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32144869
56* LXR_22292898_ChIP-Seq_THP-1_Human1.31713266
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31094055
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30276814
59ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30107065
60CLOCK_20551151_ChIP-Seq_293T_Human1.29266972
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28715578
62KDM2B_26808549_Chip-Seq_K562_Human1.28682778
63RACK7_27058665_Chip-Seq_MCF-7_Human1.27384976
64* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26223816
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24790070
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22195751
67GABP_17652178_ChIP-ChIP_JURKAT_Human1.21421366
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20350000
69* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19600441
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18947784
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18001409
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17901951
73TTF2_22483619_ChIP-Seq_HELA_Human1.17830183
74RXR_22158963_ChIP-Seq_LIVER_Mouse1.17416851
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17375723
76KDM2B_26808549_Chip-Seq_DND41_Human1.16352620
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15126180
78OCT4_18692474_ChIP-Seq_MEFs_Mouse1.14755157
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14416814
80SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13805120
81P68_20966046_ChIP-Seq_HELA_Human1.13427023
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12350421
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12238229
84* SA1_27219007_Chip-Seq_ERYTHROID_Human1.11888604
85* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11839211
86TCF7_22412390_ChIP-Seq_EML_Mouse1.11716239
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10496516
88SMC4_20622854_ChIP-Seq_HELA_Human1.10070957
89* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10066897
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10029066
91VDR_23849224_ChIP-Seq_CD4+_Human1.09981053
92CREB1_26743006_Chip-Seq_LNCaP_Human1.09830039
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09651445
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08990411
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08581895
96KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08257473
97* TP53_22127205_ChIP-Seq_IMR90_Human1.08041997
98TFEB_21752829_ChIP-Seq_HELA_Human1.08031954
99ESR2_21235772_ChIP-Seq_MCF-7_Human1.06892437
100* FOXP3_21729870_ChIP-Seq_TREG_Human1.05145592
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04094494
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03352205
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.02796554
104NANOG_21062744_ChIP-ChIP_HESCs_Human1.00850670
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00808624
106GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00648175
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00545256
108SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00147510
109FOXP1_21924763_ChIP-Seq_HESCs_Human0.99886122
110ERG_21242973_ChIP-ChIP_JURKAT_Human0.99265715
111KDM2B_26808549_Chip-Seq_JURKAT_Human0.99216029
112TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98323466
113ELF1_20517297_ChIP-Seq_JURKAT_Human0.97949989
114UBF1/2_26484160_Chip-Seq_HMECs_Human0.97592728
115CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96440001
116PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96065377
117KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95980834
118STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95763596
119* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95633950
120MAF_26560356_Chip-Seq_TH1_Human0.95487192
121ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94979866
122RARA_24833708_ChIP-Seq_LIVER_Mouse0.94677618
123CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94436331
124NCOR1_26117541_ChIP-Seq_K562_Human0.94265638
125UTX_26944678_Chip-Seq_JUKART_Human0.94116032
126HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92989608
127TET1_21451524_ChIP-Seq_MESCs_Mouse0.92964186
128* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92873849
129* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92441812
130KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92410069

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.57842864
2MP0003693_abnormal_embryo_hatching3.54515679
3MP0005451_abnormal_body_composition3.24487062
4MP0004957_abnormal_blastocyst_morpholog3.22808402
5MP0003111_abnormal_nucleus_morphology3.19795702
6MP0010352_gastrointestinal_tract_polyps3.00729422
7MP0002877_abnormal_melanocyte_morpholog2.93673534
8MP0009840_abnormal_foam_cell2.66102993
9MP0003806_abnormal_nucleotide_metabolis2.59384846
10MP0003077_abnormal_cell_cycle2.44521287
11MP0001730_embryonic_growth_arrest2.39786399
12MP0010094_abnormal_chromosome_stability2.33909098
13MP0005058_abnormal_lysosome_morphology2.09882758
14MP0000678_abnormal_parathyroid_gland2.09227342
15MP0004858_abnormal_nervous_system2.06206381
16MP0010234_abnormal_vibrissa_follicle1.84768223
17MP0005623_abnormal_meninges_morphology1.83168232
18MP0000350_abnormal_cell_proliferation1.79618581
19MP0000537_abnormal_urethra_morphology1.78108390
20MP0005076_abnormal_cell_differentiation1.77575496
21MP0003123_paternal_imprinting1.75950992
22MP0003566_abnormal_cell_adhesion1.74439616
23MP0001672_abnormal_embryogenesis/_devel1.73808026
24MP0005380_embryogenesis_phenotype1.73808026
25MP0010030_abnormal_orbit_morphology1.73575864
26MP0001849_ear_inflammation1.67399357
27MP0001697_abnormal_embryo_size1.67358543
28MP0002080_prenatal_lethality1.65431400
29MP0010307_abnormal_tumor_latency1.65076705
30MP0003984_embryonic_growth_retardation1.64925787
31MP0008260_abnormal_autophagy1.64408966
32MP0000003_abnormal_adipose_tissue1.64040614
33MP0003453_abnormal_keratinocyte_physiol1.63707930
34MP0002088_abnormal_embryonic_growth/wei1.63273986
35MP0000750_abnormal_muscle_regeneration1.59140595
36MP0004197_abnormal_fetal_growth/weight/1.58554103
37MP0005360_urolithiasis1.57948047
38MP0002653_abnormal_ependyma_morphology1.57916348
39MP0004272_abnormal_basement_membrane1.57384590
40MP0002084_abnormal_developmental_patter1.56370985
41MP0002139_abnormal_hepatobiliary_system1.53162743
42MP0002269_muscular_atrophy1.53147871
43MP0002086_abnormal_extraembryonic_tissu1.52352456
44MP0002085_abnormal_embryonic_tissue1.51883467
45MP0008932_abnormal_embryonic_tissue1.51467185
46MP0005257_abnormal_intraocular_pressure1.49126800
47MP0008007_abnormal_cellular_replicative1.44235367
48MP0004233_abnormal_muscle_weight1.43744500
49MP0001661_extended_life_span1.43113761
50MP0000858_altered_metastatic_potential1.37260562
51MP0009278_abnormal_bone_marrow1.37088992
52MP0003567_abnormal_fetal_cardiomyocyte1.36037151
53MP0002060_abnormal_skin_morphology1.35866565
54MP0005023_abnormal_wound_healing1.34057986
55MP0003221_abnormal_cardiomyocyte_apopto1.33472588
56MP0001348_abnormal_lacrimal_gland1.32556060
57MP0000747_muscle_weakness1.30249675
58MP0003283_abnormal_digestive_organ1.29002067
59MP0003119_abnormal_digestive_system1.28508181
60MP0009053_abnormal_anal_canal1.26567296
61MP0003091_abnormal_cell_migration1.25732707
62MP0005409_darkened_coat_color1.21553130
63MP0004084_abnormal_cardiac_muscle1.20671410
64MP0000733_abnormal_muscle_development1.19611932
65MP0009672_abnormal_birth_weight1.19516347
66MP0002249_abnormal_larynx_morphology1.18040384
67MP0000467_abnormal_esophagus_morphology1.17625518
68MP0002396_abnormal_hematopoietic_system1.14736955
69MP0003941_abnormal_skin_development1.14053846
70MP0000358_abnormal_cell_content/1.12613506
71MP0000579_abnormal_nail_morphology1.12089500
72MP0000490_abnormal_crypts_of1.11265299
73MP0001216_abnormal_epidermal_layer1.08508703
74MP0005330_cardiomyopathy1.07898932
75MP0005365_abnormal_bile_salt1.07562355
76MP0002019_abnormal_tumor_incidence1.04821319
77MP0004087_abnormal_muscle_fiber1.04320545
78MP0001545_abnormal_hematopoietic_system1.02638041
79MP0005397_hematopoietic_system_phenotyp1.02638041
80MP0000762_abnormal_tongue_morphology1.02393257
81MP0004185_abnormal_adipocyte_glucose1.02371843
82MP0000566_synostosis1.02345060
83MP0000313_abnormal_cell_death1.01180173
84MP0005501_abnormal_skin_physiology0.98747349
85MP0006054_spinal_hemorrhage0.98209314
86MP0005666_abnormal_adipose_tissue0.98097145
87MP0010630_abnormal_cardiac_muscle0.96931563
88MP0003315_abnormal_perineum_morphology0.96832929
89MP0008058_abnormal_DNA_repair0.96492090
90MP0005083_abnormal_biliary_tract0.96197852
91MP0005085_abnormal_gallbladder_physiolo0.96166770
92MP0000751_myopathy0.95821540
93MP0000534_abnormal_ureter_morphology0.94750364
94MP0001915_intracranial_hemorrhage0.93792154
95MP0004264_abnormal_extraembryonic_tissu0.91110379
96MP0003646_muscle_fatigue0.90929163
97MP0000598_abnormal_liver_morphology0.90918393
98MP0005319_abnormal_enzyme/_coenzyme0.90762200
99MP0000609_abnormal_liver_physiology0.90185879
100MP0008961_abnormal_basal_metabolism0.89941997
101MP0000627_abnormal_mammary_gland0.89704711
102MP0008057_abnormal_DNA_replication0.89608731
103MP0005332_abnormal_amino_acid0.89319082
104MP0002098_abnormal_vibrissa_morphology0.89144183
105MP0009333_abnormal_splenocyte_physiolog0.87722300
106MP0002089_abnormal_postnatal_growth/wei0.87325488
107MP0002796_impaired_skin_barrier0.86414104
108MP0003191_abnormal_cellular_cholesterol0.85254476
109MP0002111_abnormal_tail_morphology0.84801374
110MP0003942_abnormal_urinary_system0.84534790
111MP0004782_abnormal_surfactant_physiolog0.83819622
112MP0003329_amyloid_beta_deposits0.82912617
113MP0009931_abnormal_skin_appearance0.82712065
114MP0006036_abnormal_mitochondrial_physio0.82664629
115MP0004947_skin_inflammation0.81967720
116MP0008770_decreased_survivor_rate0.81864366
117MP0005670_abnormal_white_adipose0.81244654
118MP0003300_gastrointestinal_ulcer0.81194844
119MP0003786_premature_aging0.80310525
120MP0005375_adipose_tissue_phenotype0.80124823
121MP0009643_abnormal_urine_homeostasis0.79725760
122MP0000428_abnormal_craniofacial_morphol0.79714669
123MP0000477_abnormal_intestine_morphology0.79514929
124MP0000377_abnormal_hair_follicle0.78629727
125MP0008438_abnormal_cutaneous_collagen0.77579721
126MP0000266_abnormal_heart_morphology0.77554350
127MP0004808_abnormal_hematopoietic_stem0.77547112
128MP0001881_abnormal_mammary_gland0.77118309
129MP0003718_maternal_effect0.75156864
130MP0003115_abnormal_respiratory_system0.74751629
131MP0003385_abnormal_body_wall0.73729566
132MP0000759_abnormal_skeletal_muscle0.72690527
133MP0005621_abnormal_cell_physiology0.71249321
134MP0010329_abnormal_lipoprotein_level0.71082617
135MP0002970_abnormal_white_adipose0.70709718
136MP0005384_cellular_phenotype0.69252681

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.39150824
2Distal lower limb amyotrophy (HP:0008944)3.35676216
3Multiple enchondromatosis (HP:0005701)3.32969555
4Selective tooth agenesis (HP:0001592)3.04185293
5Difficulty climbing stairs (HP:0003551)2.99321157
6Protrusio acetabuli (HP:0003179)2.93070057
7Centrally nucleated skeletal muscle fibers (HP:0003687)2.77969223
8Vertebral compression fractures (HP:0002953)2.77336415
9Cholecystitis (HP:0001082)2.70047105
10Abnormal gallbladder physiology (HP:0012438)2.70047105
11Flat acetabular roof (HP:0003180)2.68415607
12Spastic diplegia (HP:0001264)2.66113554
13Hyperacusis (HP:0010780)2.64658880
14Progressive muscle weakness (HP:0003323)2.64456503
15Cerebral aneurysm (HP:0004944)2.62936042
16Increased connective tissue (HP:0009025)2.60944613
17Achilles tendon contracture (HP:0001771)2.57226608
18Abnormality of the Achilles tendon (HP:0005109)2.56237100
19Trismus (HP:0000211)2.54334710
20Angiofibromas (HP:0010615)2.52686321
21Adenoma sebaceum (HP:0009720)2.52686321
22Lower limb amyotrophy (HP:0007210)2.50538946
23Ankle contracture (HP:0006466)2.50340739
24Hand muscle atrophy (HP:0009130)2.49977879
25Distal upper limb amyotrophy (HP:0007149)2.47502996
26Upper limb amyotrophy (HP:0009129)2.47502996
27Abnormality of the lower motor neuron (HP:0002366)2.38695432
28Back pain (HP:0003418)2.38646210
29Rhabdomyolysis (HP:0003201)2.36903954
30Disproportionate tall stature (HP:0001519)2.36465859
31Gout (HP:0001997)2.32199609
32Long palpebral fissure (HP:0000637)2.30066935
33Distal lower limb muscle weakness (HP:0009053)2.29496534
34Hyperglycinuria (HP:0003108)2.29143933
35Astrocytoma (HP:0009592)2.28726991
36Abnormality of the astrocytes (HP:0100707)2.28726991
37Oral leukoplakia (HP:0002745)2.26166075
38Breast hypoplasia (HP:0003187)2.25966982
39Abnormality of the calcaneus (HP:0008364)2.24703055
40Broad face (HP:0000283)2.21398884
41Myoglobinuria (HP:0002913)2.17296384
42Abnormality of the anterior horn cell (HP:0006802)2.16998403
43Degeneration of anterior horn cells (HP:0002398)2.16998403
44Spinal rigidity (HP:0003306)2.12810493
45Ankyloglossia (HP:0010296)2.12101628
46Asymmetry of the thorax (HP:0001555)2.10975099
47Biconcave vertebral bodies (HP:0004586)2.08032163
48Pelvic girdle muscle weakness (HP:0003749)2.08019169
49Abnormality of the distal phalanges of the toes (HP:0010182)2.05297974
50Advanced eruption of teeth (HP:0006288)2.04430318
51Abnormality of monocarboxylic acid metabolism (HP:0010996)2.03659541
52Hyperammonemia (HP:0001987)2.02768157
53Calcaneovalgus deformity (HP:0001848)1.99980151
54Overriding aorta (HP:0002623)1.99818550
55Patellar dislocation (HP:0002999)1.99458756
56Abnormal cartilage morphology (HP:0002763)1.99290453
57Abnormality of serine family amino acid metabolism (HP:0010894)1.98720502
58Abnormality of glycine metabolism (HP:0010895)1.98720502
59Premature rupture of membranes (HP:0001788)1.98428383
60Short nail (HP:0001799)1.96849282
61Fragile skin (HP:0001030)1.95930280
62Termporal pattern (HP:0011008)1.95043601
63Insidious onset (HP:0003587)1.95043601
64Microretrognathia (HP:0000308)1.94509645
65Pseudobulbar signs (HP:0002200)1.94362429
66Hyperglycinemia (HP:0002154)1.93458682
67Shallow orbits (HP:0000586)1.92830668
68Dysmetric saccades (HP:0000641)1.91526219
69Limb-girdle muscle atrophy (HP:0003797)1.91226615
70Elfin facies (HP:0004428)1.91171029
71Reticulocytosis (HP:0001923)1.90610543
72Basal cell carcinoma (HP:0002671)1.89859610
73Birth length less than 3rd percentile (HP:0003561)1.89695733
74Abnormality of the umbilical cord (HP:0010881)1.89146613
75Myopathic facies (HP:0002058)1.89016407
76Ulnar bowing (HP:0003031)1.88965023
77Carpal bone hypoplasia (HP:0001498)1.87115215
78Abnormality of oral frenula (HP:0000190)1.86996704
79Sparse lateral eyebrow (HP:0005338)1.86328531
80Abnormality of pyrimidine metabolism (HP:0004353)1.86186550
81Mildly elevated creatine phosphokinase (HP:0008180)1.86142066
82Genu recurvatum (HP:0002816)1.85990718
83Abnormality of cells of the erythroid lineage (HP:0012130)1.85805754
84Colon cancer (HP:0003003)1.84513374
85Abnormality of reticulocytes (HP:0004312)1.81959160
86Natal tooth (HP:0000695)1.81682074
87Abnormality of skeletal muscle fiber size (HP:0012084)1.81673881
88Abnormality of the tricuspid valve (HP:0001702)1.81292519
89Deformed tarsal bones (HP:0008119)1.81098485
90Muscle fiber splitting (HP:0003555)1.80625593
91Cerebral hypomyelination (HP:0006808)1.80480064
92Ulnar deviation of the wrist (HP:0003049)1.80123384
93Slender long bone (HP:0003100)1.79704788
94Premature ovarian failure (HP:0008209)1.79640426
95Neoplasm of the pancreas (HP:0002894)1.79158757
96Renal duplication (HP:0000075)1.78301644
97Deep venous thrombosis (HP:0002625)1.77713816
98Insomnia (HP:0100785)1.77408181
99Late onset (HP:0003584)1.77279204
100Abnormality of the thoracic spine (HP:0100711)1.77109940
101Polycythemia (HP:0001901)1.76450263
102Premature skin wrinkling (HP:0100678)1.76343572
103Aneurysm (HP:0002617)1.76166246
104Ragged-red muscle fibers (HP:0003200)1.76069977
105Thin ribs (HP:0000883)1.76004656
106Atrophic scars (HP:0001075)1.75997310
107Bladder diverticulum (HP:0000015)1.75667971
108Bowel incontinence (HP:0002607)1.74811068
109Increased variability in muscle fiber diameter (HP:0003557)1.73393093
110High pitched voice (HP:0001620)1.73155145
111Elbow flexion contracture (HP:0002987)1.72901850
112Exercise-induced myalgia (HP:0003738)1.72461833
113Abnormal number of erythroid precursors (HP:0012131)1.72430145
114Pointed chin (HP:0000307)1.72306542
115Rough bone trabeculation (HP:0100670)1.72272405
116Abnormality of glycolysis (HP:0004366)1.72023990
117Xanthomatosis (HP:0000991)1.70512967
118Rhabdomyosarcoma (HP:0002859)1.70083588
119Hyperparathyroidism (HP:0000843)1.70062784
120Shoulder girdle muscle weakness (HP:0003547)1.69353960
121Abnormality of the distal phalanx of the thumb (HP:0009617)1.69251759
122Abnormal large intestine physiology (HP:0012700)1.69005250
123Progressive external ophthalmoplegia (HP:0000590)1.68956249
124Abnormal neuron morphology (HP:0012757)1.68865800
125Abnormality of the motor neurons (HP:0002450)1.68865800
126Lymphangioma (HP:0100764)1.68827094
127Breech presentation (HP:0001623)1.68711806
128Patellar aplasia (HP:0006443)1.68396348
129Blue sclerae (HP:0000592)1.68313232
130Fibroma (HP:0010614)1.67857437
131Glioma (HP:0009733)1.67811709
132Exercise-induced muscle cramps (HP:0003710)1.67366445
133Mesangial abnormality (HP:0001966)1.66631647
134Reticulocytopenia (HP:0001896)1.66578925
135Truncus arteriosus (HP:0001660)1.65456561
136Aplasia/Hypoplasia of the patella (HP:0006498)1.63967150
137Flattened epiphyses (HP:0003071)1.63662165
138Metaphyseal cupping (HP:0003021)1.63328682
139Overlapping toe (HP:0001845)1.62717672
140Right ventricular cardiomyopathy (HP:0011663)1.62553147
141Arnold-Chiari malformation (HP:0002308)1.61950661
142Personality changes (HP:0000751)1.61758147
143Enlarged penis (HP:0000040)1.61633508
144Abnormality of the musculature of the pelvis (HP:0001469)1.61595331
145Abnormality of the hip-girdle musculature (HP:0001445)1.61595331
146Neoplasm of striated muscle (HP:0009728)1.61506021
147Abnormality of carpal bone ossification (HP:0006257)1.61243527
148Atrophy/Degeneration involving motor neurons (HP:0007373)1.61078140
149Proximal placement of thumb (HP:0009623)1.60452319
150Cervical subluxation (HP:0003308)1.59358077
151Abnormal ossification of hand bones (HP:0005921)1.59311370
152Atrioventricular block (HP:0001678)1.58858101
153Cholelithiasis (HP:0001081)1.58532891
154Cerebral inclusion bodies (HP:0100314)1.58203167
155Increased nuchal translucency (HP:0010880)1.57981730
156Deviation of the thumb (HP:0009603)1.57611780
157Stridor (HP:0010307)1.57506669
158Missing ribs (HP:0000921)1.57406123
159Unilateral renal agenesis (HP:0000122)1.56958221
160Myocardial infarction (HP:0001658)1.56150002
161Abnormal umbilical cord blood vessels (HP:0011403)1.55920759
162Single umbilical artery (HP:0001195)1.55920759
163Abnormality of the fetal cardiovascular system (HP:0010948)1.55920759
164Hammertoe (HP:0001765)1.55866232
165Osteolytic defects of the hand bones (HP:0009699)1.55693513
166Osteolytic defects of the phalanges of the hand (HP:0009771)1.55693513
167Renovascular hypertension (HP:0100817)1.55121772
168Mitral regurgitation (HP:0001653)1.53913160
169Generalized amyotrophy (HP:0003700)1.53170754
170Thin bony cortex (HP:0002753)1.52842561

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.22269592
2SMG13.82760713
3PKN23.66622181
4EEF2K3.60103810
5BUB13.21368062
6NEK12.94057037
7IRAK32.55513617
8WEE12.53048179
9EPHA22.52781991
10MAP3K102.40268657
11PRPF4B2.33178808
12NEK22.26096963
13ERN12.10287924
14BCKDK2.04263314
15CDC72.00055111
16RPS6KB21.86525860
17TTN1.84838507
18MST1R1.83853161
19SCYL21.78066584
20TESK21.72994040
21CDK121.72564139
22LATS21.64798453
23TTK1.56771788
24MAPKAPK31.55721656
25PAK41.52471197
26MAP3K111.52323968
27MAP3K81.48694536
28NME21.43317229
29CDK41.38595383
30ARAF1.35694397
31LRRK21.34265902
32TAOK11.34136787
33TSSK61.32852629
34ICK1.30913087
35ALK1.29045921
36FLT31.25882761
37PTK61.21780001
38PDGFRA1.21418021
39PASK1.20953508
40RPS6KA41.19881190
41EIF2AK11.19148092
42CDK71.17801921
43KDR1.17638079
44STK101.17439168
45MAP2K31.15399559
46MTOR1.12306133
47NTRK11.07818810
48CAMK1D1.05269174
49PLK11.04068406
50AURKA1.00771114
51TGFBR10.98275987
52DYRK30.95570226
53SIK10.95372773
54TESK10.91904328
55MET0.91815352
56AURKB0.89054354
57FGFR40.87705130
58BMX0.87064618
59MAP3K130.85640393
60KSR20.83922171
61PAK20.83362536
62RIPK10.83192425
63MAP2K20.81405906
64BRAF0.80000712
65PAK10.77530994
66CDK90.74932976
67BRSK10.74704551
68CHEK10.70533198
69AKT20.70076661
70PDK30.69566517
71PDK40.69566517
72MAP4K10.68499594
73ILK0.67781360
74BRSK20.67514525
75MAP3K30.67384848
76ATR0.65459496
77MATK0.63509053
78CDK60.62100920
79PTK20.61494052
80LATS10.59768030
81TAOK20.59050284
82MAPK110.58804050
83CAMK1G0.58034750
84VRK20.57797615
85PBK0.56764532
86PRKCI0.56416879
87CDK11A0.56414226
88ZAP700.56270753
89CDK20.56095713
90GRK60.55017549
91CDK150.54875827
92EPHB10.52376189
93ERBB40.51879956
94PRKD30.51839644
95MAP3K10.51824160
96TYRO30.50903366
97DDR20.50650888
98SRPK10.50152567
99CDK180.49666489
100BRD40.49433730
101CHEK20.49023353
102ACVR1B0.48618663
103RPS6KA20.48195913
104PDPK10.47943855
105PRKG20.47864279
106FGFR10.47699867
107MARK20.46155685
108PIM20.45709705
109CDK80.44341323
110CDK140.43841358
111CDC42BPA0.41789021
112RPS6KA10.40812129
113PRKD20.39956547
114DAPK10.39822387
115CSNK1E0.39744178
116MOS0.38649066
117CLK10.38318261
118PIM10.37553378
119LMTK20.35865327
120IRAK20.35144705
121RPS6KC10.34800535
122DYRK1B0.34473285
123RAF10.31916689
124EIF2AK30.31519396
125PAK60.31123664
126CSNK2A20.31018058
127MAP3K90.29776673
128STK40.29346636
129MAP2K10.29335894
130STK30.27368285
131DAPK30.27333004
132PLK40.27306979
133MAP3K70.27219259
134CDK10.25836240
135LIMK10.25441100
136MAP3K50.23556471

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.48452005
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.15476023
3One carbon pool by folate_Homo sapiens_hsa006702.74116187
4Mismatch repair_Homo sapiens_hsa034302.50681420
5RNA transport_Homo sapiens_hsa030132.48790268
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.48010871
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.47087597
8Biosynthesis of amino acids_Homo sapiens_hsa012302.41040868
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.37453413
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.33871513
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.30376884
12Spliceosome_Homo sapiens_hsa030402.21425338
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.09239415
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.07464648
15Base excision repair_Homo sapiens_hsa034102.05752949
16Carbon metabolism_Homo sapiens_hsa012002.01249862
17Other glycan degradation_Homo sapiens_hsa005111.87146646
18Selenocompound metabolism_Homo sapiens_hsa004501.86490453
19Cell cycle_Homo sapiens_hsa041101.78101449
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.67609907
21Pentose phosphate pathway_Homo sapiens_hsa000301.65811185
22Sulfur relay system_Homo sapiens_hsa041221.65370681
23Ribosome_Homo sapiens_hsa030101.59505387
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58146861
25Folate biosynthesis_Homo sapiens_hsa007901.54520244
26Nucleotide excision repair_Homo sapiens_hsa034201.54245504
27Pancreatic cancer_Homo sapiens_hsa052121.51901686
28* Proteasome_Homo sapiens_hsa030501.39992107
29Nitrogen metabolism_Homo sapiens_hsa009101.37459171
30Prion diseases_Homo sapiens_hsa050201.36570911
31Arginine biosynthesis_Homo sapiens_hsa002201.35076199
32Pyrimidine metabolism_Homo sapiens_hsa002401.34866604
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34810763
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34417938
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.33988399
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27812174
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18045918
38RNA polymerase_Homo sapiens_hsa030201.17750245
39mRNA surveillance pathway_Homo sapiens_hsa030151.16562671
40p53 signaling pathway_Homo sapiens_hsa041151.16251346
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.14151604
42Fatty acid degradation_Homo sapiens_hsa000711.13837506
43Bladder cancer_Homo sapiens_hsa052191.13166023
44Glioma_Homo sapiens_hsa052141.08199637
45Fructose and mannose metabolism_Homo sapiens_hsa000511.07697676
46Vibrio cholerae infection_Homo sapiens_hsa051101.07193988
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06862427
48Thyroid cancer_Homo sapiens_hsa052161.04750773
49ErbB signaling pathway_Homo sapiens_hsa040121.04398509
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97434768
51Vitamin B6 metabolism_Homo sapiens_hsa007500.97329112
52Pyruvate metabolism_Homo sapiens_hsa006200.95630306
53Prostate cancer_Homo sapiens_hsa052150.95435012
54Focal adhesion_Homo sapiens_hsa045100.94095483
55Homologous recombination_Homo sapiens_hsa034400.93982266
56Lysine degradation_Homo sapiens_hsa003100.93903131
57Renal cell carcinoma_Homo sapiens_hsa052110.91988700
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91266420
59mTOR signaling pathway_Homo sapiens_hsa041500.89500600
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.86808590
61Chronic myeloid leukemia_Homo sapiens_hsa052200.84228526
62Galactose metabolism_Homo sapiens_hsa000520.84188085
63Arginine and proline metabolism_Homo sapiens_hsa003300.83793842
64Phenylalanine metabolism_Homo sapiens_hsa003600.82994783
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81278188
66Small cell lung cancer_Homo sapiens_hsa052220.77325036
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75784885
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75515500
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75456649
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74314268
71Shigellosis_Homo sapiens_hsa051310.74298932
72Viral carcinogenesis_Homo sapiens_hsa052030.74290058
73Propanoate metabolism_Homo sapiens_hsa006400.74258803
74Hippo signaling pathway_Homo sapiens_hsa043900.74235717
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73221010
76Fatty acid metabolism_Homo sapiens_hsa012120.68637816
77Tryptophan metabolism_Homo sapiens_hsa003800.68591605
78Notch signaling pathway_Homo sapiens_hsa043300.68415601
79Fat digestion and absorption_Homo sapiens_hsa049750.68227161
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.67720650
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65547984
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65497816
83HTLV-I infection_Homo sapiens_hsa051660.64924511
84Oocyte meiosis_Homo sapiens_hsa041140.63786576
85Hepatitis B_Homo sapiens_hsa051610.63559361
86Glutathione metabolism_Homo sapiens_hsa004800.63396535
87Acute myeloid leukemia_Homo sapiens_hsa052210.62975332
88AMPK signaling pathway_Homo sapiens_hsa041520.61235345
89ECM-receptor interaction_Homo sapiens_hsa045120.60753026
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60527482
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60198116
92RNA degradation_Homo sapiens_hsa030180.59444389
93Estrogen signaling pathway_Homo sapiens_hsa049150.59300978
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.58738072
95* Epstein-Barr virus infection_Homo sapiens_hsa051690.57609535
96Fatty acid biosynthesis_Homo sapiens_hsa000610.57476826
97MicroRNAs in cancer_Homo sapiens_hsa052060.56934948
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56609639
99B cell receptor signaling pathway_Homo sapiens_hsa046620.54924229
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54733704
101Insulin signaling pathway_Homo sapiens_hsa049100.54500018
102HIF-1 signaling pathway_Homo sapiens_hsa040660.51442578
103Insulin resistance_Homo sapiens_hsa049310.51203980
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50501181
105Basal cell carcinoma_Homo sapiens_hsa052170.50359175
106beta-Alanine metabolism_Homo sapiens_hsa004100.49517774
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49315344
108Endocytosis_Homo sapiens_hsa041440.49183764
109Antigen processing and presentation_Homo sapiens_hsa046120.47083044
110GnRH signaling pathway_Homo sapiens_hsa049120.47012822
111Hepatitis C_Homo sapiens_hsa051600.46732042
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46378688
113Adherens junction_Homo sapiens_hsa045200.45721413
114Proteoglycans in cancer_Homo sapiens_hsa052050.45311151
115Non-small cell lung cancer_Homo sapiens_hsa052230.44483669
116PPAR signaling pathway_Homo sapiens_hsa033200.44371091
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44136070
118VEGF signaling pathway_Homo sapiens_hsa043700.43986574
119Tight junction_Homo sapiens_hsa045300.43831845
120Amoebiasis_Homo sapiens_hsa051460.43669558
121Prolactin signaling pathway_Homo sapiens_hsa049170.42758157
122Inositol phosphate metabolism_Homo sapiens_hsa005620.42139743
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41968269
124Endometrial cancer_Homo sapiens_hsa052130.41603765
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41306109
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40610018
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39977437
128Colorectal cancer_Homo sapiens_hsa052100.39519572
129Apoptosis_Homo sapiens_hsa042100.38513636
130Bile secretion_Homo sapiens_hsa049760.37947291
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.36848916
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36516541
133Butanoate metabolism_Homo sapiens_hsa006500.35940886
134Purine metabolism_Homo sapiens_hsa002300.34535718
135Hedgehog signaling pathway_Homo sapiens_hsa043400.33500024
136Glucagon signaling pathway_Homo sapiens_hsa049220.32566489
137N-Glycan biosynthesis_Homo sapiens_hsa005100.31103867

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